reg-snw-6874

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.285	1.04e-07	2.72e-02	2.13e-02

chia-screen-data-Fav-reg-snw-6874 subnetwork

Genes (17)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Transcription factor	Chia-Hits Primary	Chia-Hits Secondary
NDUFA4L2	56901	44	-2.477	2.459	21	-	Yes	-
PHB	5245	82	-2.743	2.689	36	-	Yes	Yes
VARS	7407	60	-2.366	2.689	124	TF	Yes	-
NFATC2IP	84901	1	-1.304	2.285	4	-	-	-
FBXO22	26263	36	-1.739	2.459	208	TF	-	-
NCBP1	4686	41	-2.510	2.459	44	-	Yes	Yes
EIF2S2	8894	40	-2.999	2.459	22	-	Yes	Yes
KATNBL1	79768	2	-2.129	2.285	1	-	Yes	-
[ TAF4 ]	6874	1	-0.954	2.285	4	TF	-	-
POLR2E	5434	30	-2.037	2.644	201	TF	Yes	-
CENPQ	55166	20	-2.137	2.459	16	-	Yes	-
FUS	2521	11	-1.980	2.414	53	TF	-	-
CCT7	10574	40	-2.335	2.459	38	-	Yes	-
HNRNPU	3192	39	-2.869	2.644	33	-	Yes	-
GPS1	2873	86	-3.621	2.689	36	TF	Yes	Yes
POLH	5429	36	-2.586	2.459	24	-	Yes	Yes
PSPH	5723	14	-2.063	2.387	11	-	Yes	-

Interactions (19)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
FUS	2521	NFATC2IP	84901	pd	>	reg.ITFP.txt: no annot
VARS	7407	FBXO22	26263	pd	<>	reg.ITFP.txt: no annot
PHB	5245	VARS	7407	pd	<	reg.ITFP.txt: no annot
POLR2E	5434	VARS	7407	pd	<>	reg.ITFP.txt: no annot
PHB	5245	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
TAF4	6874	CENPQ	55166	pd	>	reg.ITFP.txt: no annot
FUS	2521	HNRNPU	3192	pd	>	reg.ITFP.txt: no annot
FBXO22	26263	NDUFA4L2	56901	pd	>	reg.ITFP.txt: no annot
GPS1	2873	PHB	5245	pd	>	reg.ITFP.txt: no annot
CCT7	10574	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
TAF4	6874	NFATC2IP	84901	pd	>	reg.ITFP.txt: no annot
FUS	2521	POLR2E	5434	pd	<>	reg.ITFP.txt: no annot
POLH	5429	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
FBXO22	26263	CENPQ	55166	pd	>	reg.ITFP.txt: no annot
NCBP1	4686	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
HNRNPU	3192	POLR2E	5434	pd	<	reg.ITFP.txt: no annot
EIF2S2	8894	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
PSPH	5723	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
FUS	2521	KATNBL1	79768	pd	>	reg.ITFP.txt: no annot

Related GO terms (163)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0010467	gene expression	1.71e-05	1.67e-01	2.910	7	49	535
GO:0005654	nucleoplasm	4.73e-05	4.62e-01	2.391	8	68	876
GO:0000398	mRNA splicing, via spliceosome	5.87e-05	5.74e-01	4.166	4	15	128
GO:0006368	transcription elongation from RNA polymerase II promoter	9.19e-05	8.97e-01	5.050	3	8	52
GO:0008380	RNA splicing	1.58e-04	1.00e+00	3.800	4	21	165
GO:0003723	RNA binding	7.33e-04	1.00e+00	3.218	4	22	247
GO:0006370	7-methylguanosine mRNA capping	7.70e-04	1.00e+00	5.581	2	5	24
GO:0050434	positive regulation of viral transcription	1.64e-03	1.00e+00	5.037	2	5	35
GO:0004832	valine-tRNA ligase activity	1.74e-03	1.00e+00	9.166	1	1	1
GO:0006438	valyl-tRNA aminoacylation	1.74e-03	1.00e+00	9.166	1	1	1
GO:0048742	regulation of skeletal muscle fiber development	3.48e-03	1.00e+00	8.166	1	1	2
GO:0004647	phosphoserine phosphatase activity	3.48e-03	1.00e+00	8.166	1	1	2
GO:0005846	nuclear cap binding complex	3.48e-03	1.00e+00	8.166	1	1	2
GO:0002176	male germ cell proliferation	3.48e-03	1.00e+00	8.166	1	1	2
GO:0005850	eukaryotic translation initiation factor 2 complex	5.21e-03	1.00e+00	7.581	1	2	3
GO:0006563	L-serine metabolic process	5.21e-03	1.00e+00	7.581	1	1	3
GO:0045292	mRNA cis splicing, via spliceosome	6.95e-03	1.00e+00	7.166	1	1	4
GO:0031442	positive regulation of mRNA 3'-end processing	6.95e-03	1.00e+00	7.166	1	1	4
GO:0006290	pyrimidine dimer repair	6.95e-03	1.00e+00	7.166	1	2	4
GO:0006564	L-serine biosynthetic process	6.95e-03	1.00e+00	7.166	1	1	4
GO:0001649	osteoblast differentiation	7.16e-03	1.00e+00	3.956	2	5	74
GO:0070934	CRD-mediated mRNA stabilization	8.68e-03	1.00e+00	6.844	1	2	5
GO:0006282	regulation of DNA repair	8.68e-03	1.00e+00	6.844	1	2	5
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	8.68e-03	1.00e+00	6.844	1	1	5
GO:0002161	aminoacyl-tRNA editing activity	8.68e-03	1.00e+00	6.844	1	1	5
GO:0030529	ribonucleoprotein complex	8.73e-03	1.00e+00	3.808	2	5	82
GO:0050847	progesterone receptor signaling pathway	1.04e-02	1.00e+00	6.581	1	2	6
GO:0001055	RNA polymerase II activity	1.04e-02	1.00e+00	6.581	1	3	6
GO:0070937	CRD-mediated mRNA stability complex	1.04e-02	1.00e+00	6.581	1	2	6
GO:0002199	zona pellucida receptor complex	1.21e-02	1.00e+00	6.359	1	4	7
GO:0000731	DNA synthesis involved in DNA repair	1.21e-02	1.00e+00	6.359	1	1	7
GO:0006301	postreplication repair	1.21e-02	1.00e+00	6.359	1	2	7
GO:0000339	RNA cap binding	1.21e-02	1.00e+00	6.359	1	1	7
GO:0005832	chaperonin-containing T-complex	1.21e-02	1.00e+00	6.359	1	4	7
GO:0005845	mRNA cap binding complex	1.38e-02	1.00e+00	6.166	1	1	8
GO:0006450	regulation of translational fidelity	1.38e-02	1.00e+00	6.166	1	1	8
GO:0010944	negative regulation of transcription by competitive promoter binding	1.38e-02	1.00e+00	6.166	1	1	8
GO:0010388	cullin deneddylation	1.38e-02	1.00e+00	6.166	1	4	8
GO:0010225	response to UV-C	1.56e-02	1.00e+00	5.996	1	2	9
GO:0006379	mRNA cleavage	1.56e-02	1.00e+00	5.996	1	2	9
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	1.56e-02	1.00e+00	5.996	1	2	9
GO:0071354	cellular response to interleukin-6	1.56e-02	1.00e+00	5.996	1	1	9
GO:0005736	DNA-directed RNA polymerase I complex	1.73e-02	1.00e+00	5.844	1	4	10
GO:0005095	GTPase inhibitor activity	1.73e-02	1.00e+00	5.844	1	1	10
GO:0001054	RNA polymerase I activity	1.73e-02	1.00e+00	5.844	1	4	10
GO:0060766	negative regulation of androgen receptor signaling pathway	1.90e-02	1.00e+00	5.707	1	4	11
GO:0008652	cellular amino acid biosynthetic process	1.90e-02	1.00e+00	5.707	1	2	11
GO:0033276	transcription factor TFTC complex	1.90e-02	1.00e+00	5.707	1	3	11
GO:0008334	histone mRNA metabolic process	1.90e-02	1.00e+00	5.707	1	1	11
GO:0006366	transcription from RNA polymerase II promoter	1.99e-02	1.00e+00	2.337	3	23	341
GO:0005737	cytoplasm	2.04e-02	1.00e+00	0.973	9	127	2633
GO:0005666	DNA-directed RNA polymerase III complex	2.24e-02	1.00e+00	5.466	1	3	13
GO:0005665	DNA-directed RNA polymerase II, core complex	2.24e-02	1.00e+00	5.466	1	3	13
GO:0001056	RNA polymerase III activity	2.24e-02	1.00e+00	5.466	1	3	13
GO:0005829	cytosol	2.39e-02	1.00e+00	1.170	7	88	1787
GO:0006386	termination of RNA polymerase III transcription	2.41e-02	1.00e+00	5.359	1	3	14
GO:0005739	mitochondrion	2.41e-02	1.00e+00	1.802	4	32	659
GO:0006385	transcription elongation from RNA polymerase III promoter	2.41e-02	1.00e+00	5.359	1	3	14
GO:0016575	histone deacetylation	2.41e-02	1.00e+00	5.359	1	2	14
GO:0008135	translation factor activity, nucleic acid binding	2.58e-02	1.00e+00	5.259	1	4	15
GO:0000188	inactivation of MAPK activity	2.58e-02	1.00e+00	5.259	1	1	15
GO:0007339	binding of sperm to zona pellucida	2.58e-02	1.00e+00	5.259	1	4	15
GO:0006352	DNA-templated transcription, initiation	2.58e-02	1.00e+00	5.259	1	3	15
GO:0005634	nucleus	2.66e-02	1.00e+00	0.823	10	158	3246
GO:0003887	DNA-directed DNA polymerase activity	2.75e-02	1.00e+00	5.166	1	2	16
GO:0031667	response to nutrient levels	2.92e-02	1.00e+00	5.078	1	2	17
GO:0003899	DNA-directed RNA polymerase activity	3.09e-02	1.00e+00	4.996	1	3	18
GO:0031047	gene silencing by RNA	3.09e-02	1.00e+00	4.996	1	2	18
GO:0005669	transcription factor TFIID complex	3.09e-02	1.00e+00	4.996	1	3	18
GO:0071339	MLL1 complex	3.09e-02	1.00e+00	4.996	1	2	18
GO:0033574	response to testosterone	3.09e-02	1.00e+00	4.996	1	1	18
GO:0006367	transcription initiation from RNA polymerase II promoter	3.12e-02	1.00e+00	2.835	2	18	161
GO:0036464	cytoplasmic ribonucleoprotein granule	3.26e-02	1.00e+00	4.918	1	1	19
GO:0006913	nucleocytoplasmic transport	3.43e-02	1.00e+00	4.844	1	2	20
GO:0034080	CENP-A containing nucleosome assembly	3.43e-02	1.00e+00	4.844	1	2	20
GO:0001816	cytokine production	3.43e-02	1.00e+00	4.844	1	1	20
GO:0071897	DNA biosynthetic process	3.43e-02	1.00e+00	4.844	1	2	20
GO:0034660	ncRNA metabolic process	3.43e-02	1.00e+00	4.844	1	1	20
GO:0016032	viral process	3.60e-02	1.00e+00	2.009	3	30	428
GO:0051084	'de novo' posttranslational protein folding	3.76e-02	1.00e+00	4.707	1	4	22
GO:0000387	spliceosomal snRNP assembly	3.76e-02	1.00e+00	4.707	1	1	22
GO:0008180	COP9 signalosome	4.10e-02	1.00e+00	4.581	1	6	24
GO:0001541	ovarian follicle development	4.27e-02	1.00e+00	4.522	1	1	25
GO:0009267	cellular response to starvation	4.43e-02	1.00e+00	4.466	1	1	26
GO:0044822	poly(A) RNA binding	4.48e-02	1.00e+00	1.524	4	45	799
GO:0006360	transcription from RNA polymerase I promoter	4.60e-02	1.00e+00	4.411	1	4	27
GO:0006281	DNA repair	4.77e-02	1.00e+00	2.501	2	24	203
GO:0006418	tRNA aminoacylation for protein translation	4.93e-02	1.00e+00	4.308	1	4	29
GO:0006383	transcription from RNA polymerase III promoter	4.93e-02	1.00e+00	4.308	1	6	29
GO:0006446	regulation of translational initiation	4.93e-02	1.00e+00	4.308	1	2	29
GO:0005730	nucleolus	5.11e-02	1.00e+00	1.239	5	74	1217
GO:0045111	intermediate filament cytoskeleton	5.27e-02	1.00e+00	4.212	1	3	31
GO:0007254	JNK cascade	5.76e-02	1.00e+00	4.078	1	1	34
GO:0031124	mRNA 3'-end processing	5.93e-02	1.00e+00	4.037	1	4	35
GO:0044297	cell body	5.93e-02	1.00e+00	4.037	1	5	35
GO:0003743	translation initiation factor activity	6.25e-02	1.00e+00	3.956	1	8	37
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	6.42e-02	1.00e+00	3.918	1	4	38
GO:0006369	termination of RNA polymerase II transcription	6.42e-02	1.00e+00	3.918	1	5	38
GO:0006396	RNA processing	6.75e-02	1.00e+00	3.844	1	4	40
GO:0006283	transcription-coupled nucleotide-excision repair	6.75e-02	1.00e+00	3.844	1	6	40
GO:0000775	chromosome, centromeric region	6.91e-02	1.00e+00	3.808	1	6	41
GO:0003684	damaged DNA binding	6.91e-02	1.00e+00	3.808	1	1	41
GO:0006406	mRNA export from nucleus	7.40e-02	1.00e+00	3.707	1	7	44
GO:0003677	DNA binding	7.53e-02	1.00e+00	1.279	4	52	947
GO:0009612	response to mechanical stimulus	7.72e-02	1.00e+00	3.642	1	2	46
GO:0032481	positive regulation of type I interferon production	8.04e-02	1.00e+00	3.581	1	3	48
GO:0006334	nucleosome assembly	8.52e-02	1.00e+00	3.494	1	4	51
GO:0006289	nucleotide-excision repair	8.84e-02	1.00e+00	3.438	1	6	53
GO:0016311	dephosphorylation	9.16e-02	1.00e+00	3.385	1	3	55
GO:0008584	male gonad development	9.48e-02	1.00e+00	3.333	1	1	57
GO:0042826	histone deacetylase binding	9.64e-02	1.00e+00	3.308	1	5	58
GO:0071013	catalytic step 2 spliceosome	1.01e-01	1.00e+00	3.235	1	5	61
GO:0006464	cellular protein modification process	1.01e-01	1.00e+00	3.235	1	4	61
GO:0030018	Z disc	1.06e-01	1.00e+00	3.166	1	3	64
GO:0030308	negative regulation of cell growth	1.15e-01	1.00e+00	3.037	1	3	70
GO:0051082	unfolded protein binding	1.15e-01	1.00e+00	3.037	1	5	70
GO:0044267	cellular protein metabolic process	1.24e-01	1.00e+00	1.707	2	14	352
GO:0042802	identical protein binding	1.25e-01	1.00e+00	1.698	2	15	354
GO:0005515	protein binding	1.28e-01	1.00e+00	0.478	10	198	4124
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1.37e-01	1.00e+00	2.774	1	5	84
GO:0045893	positive regulation of transcription, DNA-templated	1.38e-01	1.00e+00	1.608	2	21	377
GO:0000209	protein polyubiquitination	1.49e-01	1.00e+00	2.642	1	6	92
GO:0006511	ubiquitin-dependent protein catabolic process	1.49e-01	1.00e+00	2.642	1	6	92
GO:0006260	DNA replication	1.52e-01	1.00e+00	2.611	1	9	94
GO:0006457	protein folding	1.56e-01	1.00e+00	2.566	1	5	97
GO:0006413	translational initiation	1.59e-01	1.00e+00	2.537	1	6	99
GO:0034641	cellular nitrogen compound metabolic process	1.68e-01	1.00e+00	2.452	1	5	105
GO:0042981	regulation of apoptotic process	1.78e-01	1.00e+00	2.359	1	4	112
GO:0043005	neuron projection	1.80e-01	1.00e+00	2.346	1	6	113
GO:0000287	magnesium ion binding	1.83e-01	1.00e+00	2.320	1	4	115
GO:0007049	cell cycle	1.83e-01	1.00e+00	2.320	1	8	115
GO:0005524	ATP binding	1.99e-01	1.00e+00	0.950	3	37	892
GO:0044212	transcription regulatory region DNA binding	2.22e-01	1.00e+00	2.006	1	13	143
GO:0001701	in utero embryonic development	2.37e-01	1.00e+00	1.899	1	7	154
GO:0005874	microtubule	2.49e-01	1.00e+00	1.817	1	10	163
GO:0016071	mRNA metabolic process	2.58e-01	1.00e+00	1.757	1	10	170
GO:0000166	nucleotide binding	2.66e-01	1.00e+00	1.707	1	13	176
GO:0006412	translation	2.69e-01	1.00e+00	1.690	1	12	178
GO:0004842	ubiquitin-protein transferase activity	2.70e-01	1.00e+00	1.682	1	17	179
GO:0003713	transcription coactivator activity	2.76e-01	1.00e+00	1.642	1	21	184
GO:0016070	RNA metabolic process	2.82e-01	1.00e+00	1.611	1	10	188
GO:0005743	mitochondrial inner membrane	2.93e-01	1.00e+00	1.544	1	9	197
GO:0019899	enzyme binding	3.09e-01	1.00e+00	1.452	1	7	210
GO:0046982	protein heterodimerization activity	3.74e-01	1.00e+00	1.116	1	11	265
GO:0008285	negative regulation of cell proliferation	3.87e-01	1.00e+00	1.052	1	11	277
GO:0009986	cell surface	4.02e-01	1.00e+00	0.981	1	5	291
GO:0000278	mitotic cell cycle	4.27e-01	1.00e+00	0.871	1	28	314
GO:0045892	negative regulation of transcription, DNA-templated	4.30e-01	1.00e+00	0.858	1	17	317
GO:0005509	calcium ion binding	4.64e-01	1.00e+00	0.711	1	9	351
GO:0046872	metal ion binding	4.94e-01	1.00e+00	0.299	2	24	934
GO:0042803	protein homodimerization activity	5.34e-01	1.00e+00	0.424	1	13	428
GO:0045087	innate immune response	5.54e-01	1.00e+00	0.346	1	12	452
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	5.57e-01	1.00e+00	0.333	1	29	456
GO:0016020	membrane	6.40e-01	1.00e+00	-0.071	2	56	1207
GO:0005887	integral component of plasma membrane	6.44e-01	1.00e+00	-0.001	1	8	575
GO:0003700	sequence-specific DNA binding transcription factor activity	6.48e-01	1.00e+00	-0.019	1	22	582
GO:0007165	signal transduction	6.71e-01	1.00e+00	-0.106	1	24	618
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	6.87e-01	1.00e+00	-0.165	1	29	644
GO:0006355	regulation of transcription, DNA-templated	7.26e-01	1.00e+00	-0.316	1	31	715
GO:0008270	zinc ion binding	7.32e-01	1.00e+00	-0.340	1	39	727
GO:0044281	small molecule metabolic process	7.85e-01	1.00e+00	-0.555	1	35	844
GO:0070062	extracellular vesicular exosome	8.06e-01	1.00e+00	-0.514	2	51	1641
GO:0005886	plasma membrane	9.68e-01	1.00e+00	-1.635	1	46	1784

chia-Fav

reg-snw-6874

Statistics

Genes (17)

Interactions (19)

Related GO terms (163)