Related GO terms (2140)

Accession number Name Occurrences in all snw genes Occurrences in all int/reg genes
GO:1902430negative regulation of beta-amyloid formation16
GO:0009897external side of plasma membrane3131
GO:0000381regulation of alternative mRNA splicing, via spliceosome121
GO:0014013regulation of gliogenesis11
GO:0005747mitochondrial respiratory chain complex I226
GO:0044237cellular metabolic process375
GO:0005769early endosome3109
GO:0033065Rad51C-XRCC3 complex12
GO:0001558regulation of cell growth249
GO:0032839dendrite cytoplasm115
GO:0008092cytoskeletal protein binding136
GO:0008360regulation of cell shape370
GO:0004003ATP-dependent DNA helicase activity325
GO:0008094DNA-dependent ATPase activity629
GO:0006537glutamate biosynthetic process14
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity19
GO:0030168platelet activation5141
GO:0003725double-stranded RNA binding245
GO:0032287peripheral nervous system myelin maintenance15
GO:0060828regulation of canonical Wnt signaling pathway14
GO:0051092positive regulation of NF-kappaB transcription factor activity289
GO:0031047gene silencing by RNA218
GO:0045171intercellular bridge123
GO:0032781positive regulation of ATPase activity215
GO:0060325face morphogenesis122
GO:0097361CIA complex12
GO:0030316osteoclast differentiation118
GO:1990138neuron projection extension14
GO:0070628proteasome binding18
GO:0010626negative regulation of Schwann cell proliferation13
GO:0045892negative regulation of transcription, DNA-templated17317
GO:0006139nucleobase-containing compound metabolic process222
GO:0008017microtubule binding997
GO:2000641regulation of early endosome to late endosome transport15
GO:0042100B cell proliferation117
GO:0016331morphogenesis of embryonic epithelium19
GO:0030902hindbrain development214
GO:0007617mating behavior17
GO:0043199sulfate binding11
GO:0051084'de novo' posttranslational protein folding422
GO:0001522pseudouridine synthesis19
GO:0007076mitotic chromosome condensation19
GO:0072711cellular response to hydroxyurea13
GO:0033276transcription factor TFTC complex311
GO:0008283cell proliferation8239
GO:0045650negative regulation of macrophage differentiation17
GO:0032922circadian regulation of gene expression241
GO:0031122cytoplasmic microtubule organization18
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage242
GO:0004652polynucleotide adenylyltransferase activity14
GO:0046914transition metal ion binding13
GO:0030336negative regulation of cell migration360
GO:0005672transcription factor TFIIA complex15
GO:0035102PRC1 complex18
GO:0042165neurotransmitter binding14
GO:0008284positive regulation of cell proliferation8279
GO:0060179male mating behavior14
GO:0034134toll-like receptor 2 signaling pathway356
GO:0004818glutamate-tRNA ligase activity12
GO:0001823mesonephros development17
GO:0035370UBC13-UEV1A complex11
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay584
GO:0017112Rab guanyl-nucleotide exchange factor activity115
GO:0030984kininogen binding11
GO:0045944positive regulation of transcription from RNA polymerase II promoter29644
GO:0007044cell-substrate junction assembly16
GO:0009113purine nucleobase biosynthetic process15
GO:0000779condensed chromosome, centromeric region15
GO:0031011Ino80 complex38
GO:0007597blood coagulation, intrinsic pathway213
GO:0055114oxidation-reduction process9308
GO:0051963regulation of synapse assembly17
GO:0045309protein phosphorylated amino acid binding12
GO:0034162toll-like receptor 9 signaling pathway355
GO:0040038polar body extrusion after meiotic divisions14
GO:0007229integrin-mediated signaling pathway166
GO:0003712transcription cofactor activity334
GO:0007623circadian rhythm248
GO:0001661conditioned taste aversion15
GO:0045111intermediate filament cytoskeleton331
GO:0005882intermediate filament140
GO:0010388cullin deneddylation48
GO:0019388galactose catabolic process17
GO:0043966histone H3 acetylation428
GO:0040019positive regulation of embryonic development13
GO:0005847mRNA cleavage and polyadenylation specificity factor complex39
GO:0031982vesicle287
GO:0003697single-stranded DNA binding457
GO:0097193intrinsic apoptotic signaling pathway149
GO:0005125cytokine activity189
GO:0030154cell differentiation5204
GO:0000398mRNA splicing, via spliceosome15128
GO:0043066negative regulation of apoptotic process8322
GO:0048478replication fork protection14
GO:0004359glutaminase activity12
GO:1902175regulation of oxidative stress-induced intrinsic apoptotic signaling pathway13
GO:0051117ATPase binding124
GO:0043008ATP-dependent protein binding16
GO:0002474antigen processing and presentation of peptide antigen via MHC class I270
GO:0070006metalloaminopeptidase activity13
GO:0034450ubiquitin-ubiquitin ligase activity17
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening119
GO:0042583chromaffin granule11
GO:0015079potassium ion transmembrane transporter activity13
GO:0001836release of cytochrome c from mitochondria122
GO:0060169negative regulation of adenosine receptor signaling pathway11
GO:0034765regulation of ion transmembrane transport174
GO:1902187negative regulation of viral release from host cell110
GO:0004614phosphoglucomutase activity14
GO:0004972N-methyl-D-aspartate selective glutamate receptor activity16
GO:0000228nuclear chromosome228
GO:0090031positive regulation of steroid hormone biosynthetic process13
GO:0019904protein domain specific binding4130
GO:0042753positive regulation of circadian rhythm17
GO:0032272negative regulation of protein polymerization11
GO:0019899enzyme binding7210
GO:0042446hormone biosynthetic process16
GO:0001649osteoblast differentiation574
GO:0071437invadopodium13
GO:0019865immunoglobulin binding12
GO:0006360transcription from RNA polymerase I promoter427
GO:0060789hair follicle placode formation16
GO:0009749response to glucose145
GO:0005654nucleoplasm68876
GO:0006458'de novo' protein folding12
GO:0048742regulation of skeletal muscle fiber development12
GO:0009408response to heat131
GO:0043531ADP binding220
GO:0018105peptidyl-serine phosphorylation251
GO:0042048olfactory behavior13
GO:0000776kinetochore855
GO:0030032lamellipodium assembly220
GO:0051782negative regulation of cell division14
GO:0014070response to organic cyclic compound234
GO:0000922spindle pole468
GO:0046329negative regulation of JNK cascade119
GO:0060669embryonic placenta morphogenesis13
GO:0007163establishment or maintenance of cell polarity120
GO:0030183B cell differentiation143
GO:0019789SUMO ligase activity19
GO:0010460positive regulation of heart rate17
GO:0003308negative regulation of Wnt signaling pathway involved in heart development13
GO:0071013catalytic step 2 spliceosome561
GO:0032851positive regulation of Rab GTPase activity236
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process765
GO:0021695cerebellar cortex development15
GO:0051301cell division249
GO:0030529ribonucleoprotein complex582
GO:0050982detection of mechanical stimulus17
GO:0016514SWI/SNF complex313
GO:0010952positive regulation of peptidase activity111
GO:0008375acetylglucosaminyltransferase activity18
GO:0007346regulation of mitotic cell cycle221
GO:0033632regulation of cell-cell adhesion mediated by integrin13
GO:0046061dATP catabolic process13
GO:0006260DNA replication994
GO:0001890placenta development226
GO:0035019somatic stem cell maintenance332
GO:0003690double-stranded DNA binding683
GO:0035854eosinophil fate commitment12
GO:0043014alpha-tubulin binding115
GO:0007066female meiosis sister chromatid cohesion11
GO:0048471perinuclear region of cytoplasm11344
GO:0005916fascia adherens19
GO:0010767regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage11
GO:0007275multicellular organismal development9214
GO:0006433prolyl-tRNA aminoacylation12
GO:0008203cholesterol metabolic process247
GO:0003730mRNA 3'-UTR binding125
GO:0007283spermatogenesis4168
GO:0034773histone H4-K20 trimethylation14
GO:0051787misfolded protein binding28
GO:0051019mitogen-activated protein kinase binding111
GO:0016021integral component of membrane191526
GO:0050770regulation of axonogenesis313
GO:0019843rRNA binding114
GO:0043022ribosome binding217
GO:2001065mannan binding11
GO:0004181metallocarboxypeptidase activity18
GO:0030017sarcomere218
GO:0032403protein complex binding5130
GO:0018345protein palmitoylation115
GO:0000132establishment of mitotic spindle orientation212
GO:0018879biphenyl metabolic process14
GO:0019370leukotriene biosynthetic process110
GO:0032587ruffle membrane350
GO:0009117nucleotide metabolic process15
GO:0032092positive regulation of protein binding234
GO:0000012single strand break repair14
GO:0014003oligodendrocyte development115
GO:0006909phagocytosis122
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I261
GO:0071339MLL1 complex218
GO:0030014CCR4-NOT complex110
GO:0072757cellular response to camptothecin13
GO:0032039integrator complex19
GO:0008079translation termination factor activity11
GO:0043278response to morphine217
GO:0004418hydroxymethylbilane synthase activity11
GO:0045638negative regulation of myeloid cell differentiation115
GO:0045879negative regulation of smoothened signaling pathway115
GO:0005868cytoplasmic dynein complex17
GO:0032420stereocilium112
GO:0005753mitochondrial proton-transporting ATP synthase complex115
GO:0002224toll-like receptor signaling pathway383
GO:0005080protein kinase C binding231
GO:0030109HLA-B specific inhibitory MHC class I receptor activity12
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 protein120
GO:0007265Ras protein signal transduction359
GO:0034146toll-like receptor 5 signaling pathway350
GO:0045859regulation of protein kinase activity114
GO:0008217regulation of blood pressure242
GO:1902998positive regulation of neurofibrillary tangle assembly12
GO:0021586pons maturation11
GO:0071222cellular response to lipopolysaccharide264
GO:0006783heme biosynthetic process211
GO:0050482arachidonic acid secretion18
GO:0060396growth hormone receptor signaling pathway18
GO:0050681androgen receptor binding230
GO:0048468cell development110
GO:0032853positive regulation of Ran GTPase activity13
GO:0071377cellular response to glucagon stimulus220
GO:2000510positive regulation of dendritic cell chemotaxis13
GO:0051289protein homotetramerization236
GO:0035065regulation of histone acetylation15
GO:0006812cation transport116
GO:0030141secretory granule244
GO:0061141lung ciliated cell differentiation11
GO:0017056structural constituent of nuclear pore38
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle560
GO:0000724double-strand break repair via homologous recombination542
GO:0006406mRNA export from nucleus744
GO:0036289peptidyl-serine autophosphorylation13
GO:0004044amidophosphoribosyltransferase activity11
GO:0035307positive regulation of protein dephosphorylation110
GO:0035174histone serine kinase activity14
GO:0006369termination of RNA polymerase II transcription538
GO:0032508DNA duplex unwinding338
GO:0033211adiponectin-activated signaling pathway14
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle556
GO:0034142toll-like receptor 4 signaling pathway373
GO:0072307regulation of metanephric nephron tubule epithelial cell differentiation15
GO:0009411response to UV336
GO:0042060wound healing155
GO:0005200structural constituent of cytoskeleton268
GO:0019894kinesin binding121
GO:0006446regulation of translational initiation229
GO:0097481neuronal postsynaptic density19
GO:0043410positive regulation of MAPK cascade150
GO:0007161calcium-independent cell-matrix adhesion13
GO:0042323negative regulation of circadian sleep/wake cycle, non-REM sleep11
GO:0070374positive regulation of ERK1 and ERK2 cascade176
GO:0008762UDP-N-acetylmuramate dehydrogenase activity13
GO:0021766hippocampus development131
GO:0030728ovulation16
GO:0006289nucleotide-excision repair653
GO:0004656procollagen-proline 4-dioxygenase activity12
GO:0001607neuromedin U receptor activity11
GO:0005496steroid binding117
GO:0035315hair cell differentiation14
GO:0021762substantia nigra development134
GO:0004832valine-tRNA ligase activity11
GO:0008152metabolic process6182
GO:0006184GTP catabolic process7130
GO:0016607nuclear speck8122
GO:0002181cytoplasmic translation16
GO:0042054histone methyltransferase activity17
GO:0003924GTPase activity7119
GO:1901990regulation of mitotic cell cycle phase transition13
GO:0051597response to methylmercury25
GO:0033327Leydig cell differentiation110
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development15
GO:0005743mitochondrial inner membrane9197
GO:0030518intracellular steroid hormone receptor signaling pathway210
GO:0008150biological_process3270
GO:0007077mitotic nuclear envelope disassembly932
GO:0045190isotype switching113
GO:0000278mitotic cell cycle28314
GO:0006878cellular copper ion homeostasis18
GO:0045654positive regulation of megakaryocyte differentiation15
GO:0070412R-SMAD binding118
GO:0032886regulation of microtubule-based process19
GO:0030282bone mineralization121
GO:0007267cell-cell signaling1148
GO:1901315negative regulation of histone H2A K63-linked ubiquitination23
GO:0008033tRNA processing225
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle352
GO:0006379mRNA cleavage29
GO:0016071mRNA metabolic process10170
GO:0071971extracellular vesicular exosome assembly11
GO:0060135maternal process involved in female pregnancy314
GO:0034220ion transmembrane transport296
GO:0001829trophectodermal cell differentiation217
GO:0042776mitochondrial ATP synthesis coupled proton transport211
GO:0043146spindle stabilization12
GO:0046983protein dimerization activity294
GO:0097110scaffold protein binding125
GO:0071354cellular response to interleukin-619
GO:0051988regulation of attachment of spindle microtubules to kinetochore17
GO:0001570vasculogenesis245
GO:0051292nuclear pore complex assembly48
GO:0001105RNA polymerase II transcription coactivator activity219
GO:0000062fatty-acyl-CoA binding17
GO:0048820hair follicle maturation12
GO:0004708MAP kinase kinase activity28
GO:0034613cellular protein localization126
GO:0005690U4atac snRNP11
GO:0004000adenosine deaminase activity15
GO:0006414translational elongation269
GO:0050919negative chemotaxis110
GO:2000977regulation of forebrain neuron differentiation11
GO:0050766positive regulation of phagocytosis115
GO:0007179transforming growth factor beta receptor signaling pathway5107
GO:0005667transcription factor complex8147
GO:0005829cytosol881787
GO:1902004positive regulation of beta-amyloid formation13
GO:0006144purine nucleobase metabolic process224
GO:0016222procollagen-proline 4-dioxygenase complex12
GO:0030971receptor tyrosine kinase binding126
GO:0021960anterior commissure morphogenesis14
GO:0004301epoxide hydrolase activity13
GO:0010718positive regulation of epithelial to mesenchymal transition220
GO:0006189'de novo' IMP biosynthetic process15
GO:0042542response to hydrogen peroxide136
GO:0000775chromosome, centromeric region641
GO:0018146keratan sulfate biosynthetic process110
GO:0017022myosin binding216
GO:0050821protein stabilization364
GO:0001578microtubule bundle formation210
GO:0032689negative regulation of interferon-gamma production117
GO:0003707steroid hormone receptor activity142
GO:0006385transcription elongation from RNA polymerase III promoter314
GO:0000781chromosome, telomeric region229
GO:0000339RNA cap binding17
GO:0000188inactivation of MAPK activity115
GO:0007092activation of mitotic anaphase-promoting complex activity12
GO:0016485protein processing116
GO:0000096sulfur amino acid metabolic process114
GO:0032259methylation135
GO:0005778peroxisomal membrane329
GO:0008609alkylglycerone-phosphate synthase activity11
GO:0048096chromatin-mediated maintenance of transcription15
GO:0071287cellular response to manganese ion15
GO:0007005mitochondrion organization228
GO:0005789endoplasmic reticulum membrane7387
GO:0006310DNA recombination850
GO:0008334histone mRNA metabolic process111
GO:0060971embryonic heart tube left/right pattern formation14
GO:0045294alpha-catenin binding16
GO:0003181atrioventricular valve morphogenesis18
GO:0005720nuclear heterochromatin320
GO:0005575cellular_component4187
GO:0035928rRNA import into mitochondrion12
GO:0006157deoxyadenosine catabolic process11
GO:0006513protein monoubiquitination117
GO:0016573histone acetylation119
GO:0060032notochord regression12
GO:0004842ubiquitin-protein transferase activity17179
GO:0006563L-serine metabolic process13
GO:0003779actin binding3179
GO:0016671oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor12
GO:0045263proton-transporting ATP synthase complex, coupling factor F(o)13
GO:0060338regulation of type I interferon-mediated signaling pathway116
GO:0010507negative regulation of autophagy110
GO:0072520seminiferous tubule development16
GO:2000377regulation of reactive oxygen species metabolic process113
GO:0005096GTPase activator activity268
GO:0035242protein-arginine omega-N asymmetric methyltransferase activity14
GO:0031490chromatin DNA binding131
GO:0060486Clara cell differentiation14
GO:0086091regulation of heart rate by cardiac conduction111
GO:0035264multicellular organism growth254
GO:0006335DNA replication-dependent nucleosome assembly213
GO:0033523histone H2B ubiquitination17
GO:0005851eukaryotic translation initiation factor 2B complex24
GO:0035253ciliary rootlet19
GO:0001554luteolysis11
GO:0031397negative regulation of protein ubiquitination218
GO:0008611ether lipid biosynthetic process12
GO:0035335peptidyl-tyrosine dephosphorylation260
GO:0006355regulation of transcription, DNA-templated31715
GO:0035924cellular response to vascular endothelial growth factor stimulus118
GO:0000070mitotic sister chromatid segregation217
GO:0004177aminopeptidase activity314
GO:0010606positive regulation of cytoplasmic mRNA processing body assembly13
GO:0031648protein destabilization216
GO:0015992proton transport116
GO:0007018microtubule-based movement239
GO:0009409response to cold122
GO:0005813centrosome10217
GO:0008294calcium- and calmodulin-responsive adenylate cyclase activity13
GO:0009060aerobic respiration116
GO:0005687U4 snRNP19
GO:0060872semicircular canal development11
GO:0046638positive regulation of alpha-beta T cell differentiation18
GO:0031365N-terminal protein amino acid modification12
GO:0031697beta-1 adrenergic receptor binding13
GO:0010467gene expression49535
GO:0001883purine nucleoside binding11
GO:0071636positive regulation of transforming growth factor beta production13
GO:0034166toll-like receptor 10 signaling pathway350
GO:0007049cell cycle8115
GO:0042981regulation of apoptotic process4112
GO:0051015actin filament binding263
GO:2000273positive regulation of receptor activity18
GO:0007601visual perception297
GO:0031111negative regulation of microtubule polymerization or depolymerization12
GO:0045145single-stranded DNA 5'-3' exodeoxyribonuclease activity12
GO:0046854phosphatidylinositol phosphorylation115
GO:0016504peptidase activator activity19
GO:0015785UDP-galactose transport11
GO:0000185activation of MAPKKK activity16
GO:0061154endothelial tube morphogenesis14
GO:0007224smoothened signaling pathway139
GO:0042157lipoprotein metabolic process432
GO:0070062extracellular vesicular exosome511641
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway117
GO:0030036actin cytoskeleton organization490
GO:0014069postsynaptic density173
GO:0030375thyroid hormone receptor coactivator activity13
GO:0004197cysteine-type endopeptidase activity137
GO:0090314positive regulation of protein targeting to membrane29
GO:00353125'-3' exodeoxyribonuclease activity11
GO:0031941filamentous actin114
GO:0005199structural constituent of cell wall11
GO:0042995cell projection141
GO:0050908detection of light stimulus involved in visual perception19
GO:0006895Golgi to endosome transport17
GO:0005506iron ion binding492
GO:0051151negative regulation of smooth muscle cell differentiation14
GO:0061025membrane fusion113
GO:0021902commitment of neuronal cell to specific neuron type in forebrain13
GO:0043044ATP-dependent chromatin remodeling320
GO:0005739mitochondrion32659
GO:0048041focal adhesion assembly119
GO:0006851mitochondrial calcium ion transport13
GO:0000902cell morphogenesis535
GO:0050434positive regulation of viral transcription535
GO:0005915zonula adherens16
GO:0050790regulation of catalytic activity245
GO:0007417central nervous system development263
GO:0019706protein-cysteine S-palmitoyltransferase activity117
GO:0009887organ morphogenesis174
GO:0097194execution phase of apoptosis115
GO:0004768stearoyl-CoA 9-desaturase activity11
GO:0060318definitive erythrocyte differentiation14
GO:0051260protein homooligomerization287
GO:0046696lipopolysaccharide receptor complex13
GO:0006378mRNA polyadenylation318
GO:0090110cargo loading into COPII-coated vesicle12
GO:0016973poly(A)+ mRNA export from nucleus16
GO:0021983pituitary gland development222
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway228
GO:0070372regulation of ERK1 and ERK2 cascade112
GO:0097372NAD-dependent histone deacetylase activity (H3-K18 specific)18
GO:0006479protein methylation211
GO:0021591ventricular system development19
GO:0005680anaphase-promoting complex213
GO:0071564npBAF complex310
GO:0018107peptidyl-threonine phosphorylation129
GO:0035020regulation of Rac protein signal transduction15
GO:0032880regulation of protein localization123
GO:0014810positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion11
GO:0006461protein complex assembly291
GO:0072254metanephric glomerular mesangial cell differentiation11
GO:0030957Tat protein binding15
GO:0008542visual learning130
GO:0071456cellular response to hypoxia276
GO:0031072heat shock protein binding128
GO:0005956protein kinase CK2 complex11
GO:0042470melanosome364
GO:0007256activation of JNKK activity14
GO:0034663endoplasmic reticulum chaperone complex12
GO:0071371cellular response to gonadotropin stimulus111
GO:0046621negative regulation of organ growth19
GO:0017145stem cell division16
GO:0003158endothelium development15
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway27
GO:0034063stress granule assembly16
GO:0043984histone H4-K16 acetylation18
GO:0005763mitochondrial small ribosomal subunit116
GO:0050870positive regulation of T cell activation114
GO:0007062sister chromatid cohesion19
GO:0045666positive regulation of neuron differentiation353
GO:0004647phosphoserine phosphatase activity12
GO:0019898extrinsic component of membrane130
GO:0043025neuronal cell body3171
GO:0005178integrin binding368
GO:0005887integral component of plasma membrane8575
GO:0021884forebrain neuron development15
GO:2000791negative regulation of mesenchymal cell proliferation involved in lung development12
GO:0005764lysosome2100
GO:0000790nuclear chromatin9109
GO:2000463positive regulation of excitatory postsynaptic membrane potential113
GO:0022617extracellular matrix disassembly285
GO:0003887DNA-directed DNA polymerase activity216
GO:0097418neurofibrillary tangle14
GO:0007519skeletal muscle tissue development233
GO:0030324lung development162
GO:0010944negative regulation of transcription by competitive promoter binding18
GO:0051294establishment of spindle orientation12
GO:0002455humoral immune response mediated by circulating immunoglobulin16
GO:0051123RNA polymerase II transcriptional preinitiation complex assembly12
GO:0030424axon1128
GO:0016070RNA metabolic process10188
GO:0006397mRNA processing12110
GO:0004712protein serine/threonine/tyrosine kinase activity217
GO:0072687meiotic spindle12
GO:0006298mismatch repair117
GO:0030234enzyme regulator activity111
GO:0044212transcription regulatory region DNA binding13143
GO:0001894tissue homeostasis112
GO:0007568aging397
GO:0048708astrocyte differentiation17
GO:0004185serine-type carboxypeptidase activity11
GO:0097154GABAergic neuron differentiation11
GO:0016323basolateral plasma membrane3106
GO:0016817hydrolase activity, acting on acid anhydrides11
GO:0034975protein folding in endoplasmic reticulum11
GO:0008016regulation of heart contraction124
GO:0050896response to stimulus127
GO:0019233sensory perception of pain135
GO:0000118histone deacetylase complex323
GO:0032465regulation of cytokinesis110
GO:0032835glomerulus development17
GO:1902476chloride transmembrane transport236
GO:0043393regulation of protein binding214
GO:0007398ectoderm development111
GO:0032154cleavage furrow330
GO:0005525GTP binding12197
GO:0042113B cell activation116
GO:0030552cAMP binding114
GO:0010494cytoplasmic stress granule426
GO:0043539protein serine/threonine kinase activator activity112
GO:0032735positive regulation of interleukin-12 production120
GO:0044615nuclear pore nuclear basket14
GO:0043083synaptic cleft11
GO:0050775positive regulation of dendrite morphogenesis111
GO:0031589cell-substrate adhesion113
GO:0005578proteinaceous extracellular matrix4115
GO:0005262calcium channel activity125
GO:0006012galactose metabolic process15
GO:0035371microtubule plus-end213
GO:0003065positive regulation of heart rate by epinephrine11
GO:0034453microtubule anchoring19
GO:0044255cellular lipid metabolic process289
GO:0031643positive regulation of myelination17
GO:0042448progesterone metabolic process15
GO:0015288porin activity15
GO:0007140male meiosis17
GO:0005518collagen binding247
GO:0051020GTPase binding17
GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activity14
GO:0045667regulation of osteoblast differentiation28
GO:0071001U4/U6 snRNP13
GO:0042809vitamin D receptor binding211
GO:0043588skin development119
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpoint16
GO:0008565protein transporter activity235
GO:0051087chaperone binding345
GO:0002842positive regulation of T cell mediated immune response to tumor cell11
GO:0048870cell motility115
GO:0000778condensed nuclear chromosome kinetochore23
GO:0042256mature ribosome assembly13
GO:0009168purine ribonucleoside monophosphate biosynthetic process29
GO:0016568chromatin modification368
GO:0030145manganese ion binding326
GO:0042582azurophil granule14
GO:0051291protein heterooligomerization143
GO:0051571positive regulation of histone H3-K4 methylation110
GO:0002128tRNA nucleoside ribose methylation11
GO:0019948SUMO activating enzyme activity12
GO:0004674protein serine/threonine kinase activity8197
GO:0071539protein localization to centrosome14
GO:0048169regulation of long-term neuronal synaptic plasticity116
GO:0043576regulation of respiratory gaseous exchange14
GO:0042754negative regulation of circadian rhythm26
GO:0048739cardiac muscle fiber development16
GO:1900041negative regulation of interleukin-2 secretion12
GO:0035064methylated histone binding131
GO:0018149peptide cross-linking118
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway355
GO:0045947negative regulation of translational initiation19
GO:0097452GAIT complex24
GO:0048814regulation of dendrite morphogenesis111
GO:1902953positive regulation of ER to Golgi vesicle-mediated transport12
GO:00084095'-3' exonuclease activity27
GO:0051908double-stranded DNA 5'-3' exodeoxyribonuclease activity11
GO:0001822kidney development352
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process116
GO:0043931ossification involved in bone maturation15
GO:0009416response to light stimulus110
GO:0032720negative regulation of tumor necrosis factor production120
GO:0032496response to lipopolysaccharide193
GO:0051781positive regulation of cell division222
GO:0006368transcription elongation from RNA polymerase II promoter852
GO:0005761mitochondrial ribosome120
GO:0005849mRNA cleavage factor complex14
GO:0031572G2 DNA damage checkpoint215
GO:0070064proline-rich region binding114
GO:0090297positive regulation of mitochondrial DNA replication11
GO:0032727positive regulation of interferon-alpha production18
GO:0005793endoplasmic reticulum-Golgi intermediate compartment238
GO:0001816cytokine production120
GO:0010424DNA methylation on cytosine within a CG sequence13
GO:0018894dibenzo-p-dioxin metabolic process14
GO:0006607NLS-bearing protein import into nucleus112
GO:0003774motor activity129
GO:0019005SCF ubiquitin ligase complex120
GO:0008026ATP-dependent helicase activity329
GO:0045216cell-cell junction organization144
GO:0002159desmosome assembly14
GO:0045653negative regulation of megakaryocyte differentiation16
GO:0000939condensed chromosome inner kinetochore11
GO:0051262protein tetramerization223
GO:0007000nucleolus organization14
GO:0006665sphingolipid metabolic process138
GO:0060644mammary gland epithelial cell differentiation19
GO:0030666endocytic vesicle membrane136
GO:0043235receptor complex176
GO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage110
GO:0016881acid-amino acid ligase activity328
GO:0048291isotype switching to IgG isotypes11
GO:0051607defense response to virus192
GO:0006351transcription, DNA-templated471076
GO:0003676nucleic acid binding466
GO:0015991ATP hydrolysis coupled proton transport115
GO:0005615extracellular space15651
GO:0031124mRNA 3'-end processing435
GO:0006112energy reserve metabolic process365
GO:0043922negative regulation by host of viral transcription111
GO:0001774microglial cell activation19
GO:0007369gastrulation217
GO:0043032positive regulation of macrophage activation16
GO:0040037negative regulation of fibroblast growth factor receptor signaling pathway16
GO:0006805xenobiotic metabolic process394
GO:0034968histone lysine methylation19
GO:0007257activation of JUN kinase activity125
GO:0005865striated muscle thin filament13
GO:0048704embryonic skeletal system morphogenesis128
GO:0007202activation of phospholipase C activity137
GO:0032982myosin filament16
GO:0010669epithelial structure maintenance13
GO:0046103inosine biosynthetic process12
GO:0015035protein disulfide oxidoreductase activity113
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription130
GO:0051146striated muscle cell differentiation112
GO:0007616long-term memory220
GO:0007338single fertilization124
GO:0005254chloride channel activity120
GO:0008574plus-end-directed microtubule motor activity110
GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress115
GO:0000380alternative mRNA splicing, via spliceosome27
GO:0005839proteasome core complex116
GO:0032463negative regulation of protein homooligomerization13
GO:0005083small GTPase regulator activity217
GO:0031519PcG protein complex318
GO:0006200ATP catabolic process13219
GO:0050850positive regulation of calcium-mediated signaling117
GO:1901612cardiolipin binding12
GO:0009116nucleoside metabolic process14
GO:0030335positive regulation of cell migration2101
GO:0034244negative regulation of transcription elongation from RNA polymerase II promoter17
GO:0060087relaxation of vascular smooth muscle15
GO:0004521endoribonuclease activity15
GO:0032760positive regulation of tumor necrosis factor production132
GO:0090002establishment of protein localization to plasma membrane113
GO:00170053'-tyrosyl-DNA phosphodiesterase activity11
GO:0051154negative regulation of striated muscle cell differentiation13
GO:0005640nuclear outer membrane117
GO:0030553cGMP binding18
GO:0043981histone H4-K5 acetylation17
GO:0048562embryonic organ morphogenesis14
GO:0050690regulation of defense response to virus by virus122
GO:0046976histone methyltransferase activity (H3-K27 specific)14
GO:2000279negative regulation of DNA biosynthetic process16
GO:0030175filopodium137
GO:0010800positive regulation of peptidyl-threonine phosphorylation114
GO:0015758glucose transport848
GO:0038180nerve growth factor signaling pathway15
GO:0008536Ran GTPase binding121
GO:0043392negative regulation of DNA binding123
GO:0006476protein deacetylation18
GO:0019773proteasome core complex, alpha-subunit complex16
GO:0030901midbrain development125
GO:0008235metalloexopeptidase activity25
GO:0030296protein tyrosine kinase activator activity18
GO:0045893positive regulation of transcription, DNA-templated21377
GO:0045605negative regulation of epidermal cell differentiation11
GO:0010225response to UV-C29
GO:0032421stereocilium bundle13
GO:0007264small GTPase mediated signal transduction8174
GO:0070307lens fiber cell development15
GO:0001938positive regulation of endothelial cell proliferation143
GO:0061383trabecula morphogenesis11
GO:0001701in utero embryonic development7154
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription250
GO:0090344negative regulation of cell aging15
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II364
GO:0043248proteasome assembly14
GO:0008589regulation of smoothened signaling pathway113
GO:0007162negative regulation of cell adhesion224
GO:2000780negative regulation of double-strand break repair25
GO:0061198fungiform papilla formation13
GO:0005102receptor binding3174
GO:0045454cell redox homeostasis331
GO:0044267cellular protein metabolic process14352
GO:0030890positive regulation of B cell proliferation233
GO:0016125sterol metabolic process113
GO:0005856cytoskeleton8190
GO:0000910cytokinesis233
GO:0007403glial cell fate determination12
GO:0000375RNA splicing, via transesterification reactions118
GO:0007548sex differentiation112
GO:0007057spindle assembly involved in female meiosis I12
GO:0004386helicase activity342
GO:0043547positive regulation of GTPase activity2112
GO:0006405RNA export from nucleus13
GO:0051642centrosome localization17
GO:0030914STAGA complex26
GO:0004824lysine-tRNA ligase activity11
GO:0030718germ-line stem cell maintenance14
GO:0002756MyD88-independent toll-like receptor signaling pathway258
GO:0030828positive regulation of cGMP biosynthetic process14
GO:1902847regulation of neuronal signal transduction11
GO:0043406positive regulation of MAP kinase activity135
GO:0001779natural killer cell differentiation110
GO:0021954central nervous system neuron development110
GO:0005540hyaluronic acid binding111
GO:0035136forelimb morphogenesis17
GO:0000387spliceosomal snRNP assembly122
GO:0016427tRNA (cytosine) methyltransferase activity12
GO:0061077chaperone-mediated protein folding122
GO:0004839ubiquitin activating enzyme activity13
GO:0016409palmitoyltransferase activity112
GO:0008080N-acetyltransferase activity15
GO:0004871signal transducer activity4148
GO:0008137NADH dehydrogenase (ubiquinone) activity224
GO:0004827proline-tRNA ligase activity12
GO:0042339keratan sulfate metabolic process113
GO:2001243negative regulation of intrinsic apoptotic signaling pathway118
GO:0070491repressing transcription factor binding223
GO:0006979response to oxidative stress364
GO:0015966diadenosine tetraphosphate biosynthetic process12
GO:0071479cellular response to ionizing radiation224
GO:0014067negative regulation of phosphatidylinositol 3-kinase signaling17
GO:0001056RNA polymerase III activity313
GO:0000400four-way junction DNA binding37
GO:0044314protein K27-linked ubiquitination25
GO:0004427inorganic diphosphatase activity12
GO:0030216keratinocyte differentiation138
GO:0032695negative regulation of interleukin-12 production17
GO:0000780condensed nuclear chromosome, centromeric region17
GO:0045727positive regulation of translation135
GO:0033574response to testosterone118
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity567
GO:0005681spliceosomal complex855
GO:0009154purine ribonucleotide catabolic process11
GO:0016491oxidoreductase activity140
GO:0043231intracellular membrane-bounded organelle8218
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay440
GO:0022843voltage-gated cation channel activity13
GO:0046602regulation of mitotic centrosome separation12
GO:0000729DNA double-strand break processing25
GO:0001530lipopolysaccharide binding19
GO:0060749mammary gland alveolus development113
GO:0001501skeletal system development282
GO:0035690cellular response to drug138
GO:0035666TRIF-dependent toll-like receptor signaling pathway257
GO:0001158enhancer sequence-specific DNA binding115
GO:0016787hydrolase activity340
GO:0005862muscle thin filament tropomyosin13
GO:0033613activating transcription factor binding114
GO:0046826negative regulation of protein export from nucleus16
GO:0004364glutathione transferase activity114
GO:0045600positive regulation of fat cell differentiation122
GO:0070577lysine-acetylated histone binding212
GO:0001891phagocytic cup114
GO:0072334UDP-galactose transmembrane transport11
GO:0045987positive regulation of smooth muscle contraction16
GO:0071897DNA biosynthetic process220
GO:0003777microtubule motor activity339
GO:0034982mitochondrial protein processing12
GO:0051403stress-activated MAPK cascade242
GO:0032755positive regulation of interleukin-6 production127
GO:0004843ubiquitin-specific protease activity246
GO:0016262protein N-acetylglucosaminyltransferase activity11
GO:1902017regulation of cilium assembly111
GO:0006357regulation of transcription from RNA polymerase II promoter14203
GO:0050699WW domain binding114
GO:0009880embryonic pattern specification114
GO:0031514motile cilium114
GO:0005819spindle680
GO:0015629actin cytoskeleton5136
GO:0045860positive regulation of protein kinase activity237
GO:0016311dephosphorylation355
GO:0006820anion transport16
GO:0000244spliceosomal tri-snRNP complex assembly19
GO:0005634nucleus1583246
GO:0071236cellular response to antibiotic110
GO:0006417regulation of translation239
GO:0042346positive regulation of NF-kappaB import into nucleus113
GO:0070256negative regulation of mucus secretion11
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling2108
GO:0060762regulation of branching involved in mammary gland duct morphogenesis14
GO:0035257nuclear hormone receptor binding118
GO:0002368B cell cytokine production11
GO:0010971positive regulation of G2/M transition of mitotic cell cycle112
GO:0070932histone H3 deacetylation215
GO:0031988membrane-bounded vesicle16
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity358
GO:0034972histone H3-R26 methylation11
GO:0036053glomerular endothelium fenestra11
GO:0003735structural constituent of ribosome2109
GO:0036123histone H3-K9 dimethylation13
GO:0008610lipid biosynthetic process15
GO:0005765lysosomal membrane1120
GO:0070888E-box binding125
GO:0008608attachment of spindle microtubules to kinetochore16
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling19
GO:0007091metaphase/anaphase transition of mitotic cell cycle25
GO:0006958complement activation, classical pathway327
GO:0006418tRNA aminoacylation for protein translation429
GO:0032859activation of Ral GTPase activity11
GO:0039536negative regulation of RIG-I signaling pathway12
GO:0032786positive regulation of DNA-templated transcription, elongation16
GO:0005730nucleolus741217
GO:0006935chemotaxis258
GO:0006874cellular calcium ion homeostasis357
GO:0030057desmosome215
GO:0001055RNA polymerase II activity36
GO:0007030Golgi organization125
GO:0031274positive regulation of pseudopodium assembly15
GO:0046825regulation of protein export from nucleus15
GO:0008355olfactory learning12
GO:0016922ligand-dependent nuclear receptor binding215
GO:0006913nucleocytoplasmic transport220
GO:0005852eukaryotic translation initiation factor 3 complex113
GO:0048255mRNA stabilization19
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator114
GO:0005097Rab GTPase activator activity122
GO:0000338protein deneddylation13
GO:0009267cellular response to starvation126
GO:0043103hypoxanthine salvage13
GO:0048251elastic fiber assembly14
GO:0019901protein kinase binding8232
GO:0051297centrosome organization112
GO:0009791post-embryonic development252
GO:0005911cell-cell junction3104
GO:0000209protein polyubiquitination692
GO:0032790ribosome disassembly25
GO:0042974retinoic acid receptor binding110
GO:0045019negative regulation of nitric oxide biosynthetic process19
GO:0038027apolipoprotein A-I-mediated signaling pathway15
GO:0035414negative regulation of catenin import into nucleus15
GO:0042176regulation of protein catabolic process114
GO:0006336DNA replication-independent nucleosome assembly213
GO:0061647histone H3-K9 modification19
GO:0070914UV-damage excision repair16
GO:0019852L-ascorbic acid metabolic process17
GO:0006704glucocorticoid biosynthetic process18
GO:0005788endoplasmic reticulum lumen4104
GO:0048386positive regulation of retinoic acid receptor signaling pathway14
GO:0035407histone H3-T11 phosphorylation11
GO:0071243cellular response to arsenic-containing substance18
GO:0045785positive regulation of cell adhesion329
GO:0046982protein heterodimerization activity11265
GO:0016567protein ubiquitination14188
GO:0006450regulation of translational fidelity18
GO:0009368endopeptidase Clp complex12
GO:0048268clathrin coat assembly29
GO:0002023reduction of food intake in response to dietary excess12
GO:0006684sphingomyelin metabolic process12
GO:0007186G-protein coupled receptor signaling pathway4229
GO:0036089cleavage furrow formation14
GO:0016363nuclear matrix1073
GO:0035098ESC/E(Z) complex113
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic process12
GO:0031647regulation of protein stability221
GO:0008175tRNA methyltransferase activity11
GO:0097177mitochondrial ribosome binding11
GO:0060076excitatory synapse114
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity245
GO:0010918positive regulation of mitochondrial membrane potential12
GO:0071346cellular response to interferon-gamma220
GO:0033197response to vitamin E17
GO:0005846nuclear cap binding complex12
GO:0006413translational initiation699
GO:0001106RNA polymerase II transcription corepressor activity218
GO:0030198extracellular matrix organization7221
GO:0048024regulation of mRNA splicing, via spliceosome15
GO:2000323negative regulation of glucocorticoid receptor signaling pathway15
GO:0005759mitochondrial matrix7139
GO:0042393histone binding354
GO:0030321transepithelial chloride transport14
GO:0002161aminoacyl-tRNA editing activity15
GO:0010226response to lithium ion29
GO:0033077T cell differentiation in thymus226
GO:0050687negative regulation of defense response to virus17
GO:0051098regulation of binding15
GO:0004707MAP kinase activity17
GO:0010907positive regulation of glucose metabolic process17
GO:0007517muscle organ development156
GO:0043195terminal bouton231
GO:0043996histone acetyltransferase activity (H4-K8 specific)13
GO:0006171cAMP biosynthetic process112
GO:0006325chromatin organization470
GO:0005198structural molecule activity4101
GO:0042026protein refolding110
GO:0021514ventral spinal cord interneuron differentiation12
GO:0051603proteolysis involved in cellular protein catabolic process112
GO:0070371ERK1 and ERK2 cascade114
GO:0046677response to antibiotic124
GO:0004860protein kinase inhibitor activity115
GO:0060048cardiac muscle contraction126
GO:0016604nuclear body223
GO:0032947protein complex scaffold220
GO:0020037heme binding388
GO:0046111xanthine biosynthetic process11
GO:0006782protoporphyrinogen IX biosynthetic process27
GO:0031510SUMO activating enzyme complex12
GO:0008289lipid binding473
GO:0008643carbohydrate transport110
GO:0034641cellular nitrogen compound metabolic process5105
GO:0010390histone monoubiquitination28
GO:0006284base-excision repair332
GO:0035613RNA stem-loop binding14
GO:0007418ventral midline development13
GO:0000139Golgi membrane2267
GO:0006921cellular component disassembly involved in execution phase of apoptosis131
GO:0005923tight junction264
GO:0008270zinc ion binding39727
GO:1901687glutathione derivative biosynthetic process115
GO:0051382kinetochore assembly27
GO:0000127transcription factor TFIIIC complex35
GO:0007626locomotory behavior147
GO:0000718nucleotide-excision repair, DNA damage removal117
GO:0007420brain development3119
GO:0043923positive regulation by host of viral transcription110
GO:0010994free ubiquitin chain polymerization12
GO:0060766negative regulation of androgen receptor signaling pathway411
GO:0090400stress-induced premature senescence13
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway119
GO:0031965nuclear membrane8130
GO:0019003GDP binding234
GO:0005622intracellular2145
GO:0050774negative regulation of dendrite morphogenesis13
GO:0035413positive regulation of catenin import into nucleus18
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway17
GO:0031369translation initiation factor binding113
GO:0006364rRNA processing267
GO:0046582Rap GTPase activator activity13
GO:0005229intracellular calcium activated chloride channel activity15
GO:0030325adrenal gland development117
GO:0005637nuclear inner membrane120
GO:0007219Notch signaling pathway295
GO:0046972histone acetyltransferase activity (H4-K16 specific)13
GO:0007399nervous system development4152
GO:0042645mitochondrial nucleoid131
GO:0005524ATP binding37892
GO:0006869lipid transport234
GO:0006398histone mRNA 3'-end processing15
GO:0016049cell growth135
GO:0044281small molecule metabolic process35844
GO:0036310annealing helicase activity17
GO:0008076voltage-gated potassium channel complex133
GO:0017101aminoacyl-tRNA synthetase multienzyme complex12
GO:0070644vitamin D response element binding13
GO:0007020microtubule nucleation111
GO:0046716muscle cell cellular homeostasis111
GO:0019213deacetylase activity16
GO:0034969histone arginine methylation12
GO:0006297nucleotide-excision repair, DNA gap filling118
GO:0006164purine nucleotide biosynthetic process17
GO:0014047glutamate secretion112
GO:0046605regulation of centrosome cycle11
GO:0005844polysome219
GO:0030658transport vesicle membrane122
GO:0043687post-translational protein modification1116
GO:0034976response to endoplasmic reticulum stress231
GO:0030054cell junction5218
GO:0085020protein K6-linked ubiquitination26
GO:0000731DNA synthesis involved in DNA repair17
GO:0003682chromatin binding15252
GO:2000670positive regulation of dendritic cell apoptotic process13
GO:0032925regulation of activin receptor signaling pathway14
GO:0035116embryonic hindlimb morphogenesis218
GO:0019722calcium-mediated signaling122
GO:0000049tRNA binding223
GO:0001541ovarian follicle development125
GO:0007409axonogenesis245
GO:0031901early endosome membrane158
GO:0001933negative regulation of protein phosphorylation330
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding449
GO:0048167regulation of synaptic plasticity121
GO:0003714transcription corepressor activity5137
GO:0002087regulation of respiratory gaseous exchange by neurological system process16
GO:0000993RNA polymerase II core binding15
GO:0016594glycine binding19
GO:0071679commissural neuron axon guidance16
GO:0045211postsynaptic membrane1110
GO:0001835blastocyst hatching13
GO:0000942condensed nuclear chromosome outer kinetochore23
GO:0051276chromosome organization212
GO:0097440apical dendrite16
GO:0010976positive regulation of neuron projection development139
GO:0043409negative regulation of MAPK cascade110
GO:0032590dendrite membrane110
GO:0008023transcription elongation factor complex211
GO:0048025negative regulation of mRNA splicing, via spliceosome110
GO:0044609DBIRD complex11
GO:0022627cytosolic small ribosomal subunit130
GO:0005914spot adherens junction11
GO:0044070regulation of anion transport114
GO:0006449regulation of translational termination14
GO:0042586peptide deformylase activity11
GO:0042340keratan sulfate catabolic process17
GO:0008201heparin binding491
GO:0008543fibroblast growth factor receptor signaling pathway2114
GO:0033017sarcoplasmic reticulum membrane119
GO:0018024histone-lysine N-methyltransferase activity115
GO:0006975DNA damage induced protein phosphorylation16
GO:0007266Rho protein signal transduction235
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding263
GO:0007595lactation132
GO:0055074calcium ion homeostasis114
GO:0007339binding of sperm to zona pellucida415
GO:0000166nucleotide binding13176
GO:0035234ectopic germ cell programmed cell death16
GO:0018108peptidyl-tyrosine phosphorylation289
GO:1900210positive regulation of cardiolipin metabolic process11
GO:0060218hematopoietic stem cell differentiation19
GO:0019784NEDD8-specific protease activity12
GO:0000785chromatin659
GO:0072341modified amino acid binding14
GO:0060407negative regulation of penile erection11
GO:0004984olfactory receptor activity134
GO:0006356regulation of transcription from RNA polymerase I promoter15
GO:0045814negative regulation of gene expression, epigenetic17
GO:0033126positive regulation of GTP catabolic process17
GO:0008013beta-catenin binding345
GO:1903033positive regulation of microtubule plus-end binding12
GO:0048568embryonic organ development111
GO:0045471response to ethanol168
GO:0000738DNA catabolic process, exonucleolytic113
GO:0036464cytoplasmic ribonucleoprotein granule119
GO:0016327apicolateral plasma membrane17
GO:0006730one-carbon metabolic process117
GO:0043515kinetochore binding24
GO:0006508proteolysis11264
GO:0008138protein tyrosine/serine/threonine phosphatase activity117
GO:0000082G1/S transition of mitotic cell cycle4125
GO:0060315negative regulation of ryanodine-sensitive calcium-release channel activity18
GO:1901214regulation of neuron death17
GO:0042993positive regulation of transcription factor import into nucleus18
GO:0070936protein K48-linked ubiquitination135
GO:0002192IRES-dependent translational initiation23
GO:0017085response to insecticide24
GO:0045950negative regulation of mitotic recombination12
GO:0009798axis specification12
GO:0002051osteoblast fate commitment14
GO:0051131chaperone-mediated protein complex assembly310
GO:0072372primary cilium114
GO:0006888ER to Golgi vesicle-mediated transport134
GO:0008083growth factor activity187
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process438
GO:0051443positive regulation of ubiquitin-protein transferase activity214
GO:0050796regulation of insulin secretion154
GO:0004346glucose-6-phosphatase activity13
GO:0051865protein autoubiquitination231
GO:0003756protein disulfide isomerase activity17
GO:0042797tRNA transcription from RNA polymerase III promoter35
GO:0014704intercalated disc223
GO:0015078hydrogen ion transmembrane transporter activity111
GO:0009913epidermal cell differentiation25
GO:0050847progesterone receptor signaling pathway26
GO:0001525angiogenesis2146
GO:0051974negative regulation of telomerase activity15
GO:0002314germinal center B cell differentiation12
GO:0009790embryo development127
GO:0003677DNA binding52947
GO:0031593polyubiquitin binding115
GO:0010972negative regulation of G2/M transition of mitotic cell cycle12
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process15
GO:1901165positive regulation of trophoblast cell migration12
GO:0017124SH3 domain binding276
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process132
GO:0043928exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay322
GO:1900195positive regulation of oocyte maturation12
GO:0009650UV protection18
GO:0004872receptor activity4116
GO:0006939smooth muscle contraction110
GO:0051149positive regulation of muscle cell differentiation222
GO:0016300tRNA (uracil) methyltransferase activity11
GO:0045670regulation of osteoclast differentiation17
GO:0090305nucleic acid phosphodiester bond hydrolysis631
GO:0017025TBP-class protein binding112
GO:0048010vascular endothelial growth factor receptor signaling pathway116
GO:0042036negative regulation of cytokine biosynthetic process12
GO:0006349regulation of gene expression by genetic imprinting112
GO:0000733DNA strand renaturation18
GO:0051028mRNA transport547
GO:0007051spindle organization110
GO:0006821chloride transport223
GO:0072089stem cell proliferation15
GO:0032467positive regulation of cytokinesis116
GO:0009653anatomical structure morphogenesis165
GO:0016226iron-sulfur cluster assembly15
GO:0048015phosphatidylinositol-mediated signaling283
GO:0001849complement component C1q binding25
GO:0042733embryonic digit morphogenesis229
GO:0048546digestive tract morphogenesis111
GO:0002376immune system process223
GO:0060021palate development147
GO:0006974cellular response to DNA damage stimulus11121
GO:0031463Cul3-RING ubiquitin ligase complex116
GO:0031262Ndc80 complex14
GO:0030195negative regulation of blood coagulation18
GO:0071321cellular response to cGMP16
GO:0000788nuclear nucleosome15
GO:0016282eukaryotic 43S preinitiation complex111
GO:0035861site of double-strand break113
GO:0030246carbohydrate binding180
GO:0048387negative regulation of retinoic acid receptor signaling pathway29
GO:0000403Y-form DNA binding15
GO:0031100organ regeneration144
GO:0090526regulation of gluconeogenesis involved in cellular glucose homeostasis12
GO:0001568blood vessel development131
GO:0017038protein import13
GO:0021533cell differentiation in hindbrain13
GO:0007131reciprocal meiotic recombination117
GO:0045668negative regulation of osteoblast differentiation122
GO:0008180COP9 signalosome624
GO:0006154adenosine catabolic process12
GO:0000405bubble DNA binding14
GO:0007165signal transduction24618
GO:0042482positive regulation of odontogenesis15
GO:0005669transcription factor TFIID complex318
GO:0032873negative regulation of stress-activated MAPK cascade15
GO:0046777protein autophosphorylation3106
GO:0000151ubiquitin ligase complex448
GO:0051726regulation of cell cycle373
GO:0006629lipid metabolic process265
GO:0071108protein K48-linked deubiquitination113
GO:0033093Weibel-Palade body14
GO:0048873homeostasis of number of cells within a tissue214
GO:0071425hematopoietic stem cell proliferation18
GO:0051321meiotic cell cycle120
GO:0001709cell fate determination111
GO:0046632alpha-beta T cell differentiation15
GO:0001671ATPase activator activity16
GO:0006954inflammatory response3185
GO:0008134transcription factor binding10209
GO:0005783endoplasmic reticulum12381
GO:0060337type I interferon signaling pathway145
GO:0003746translation elongation factor activity212
GO:0007263nitric oxide mediated signal transduction112
GO:0016274protein-arginine N-methyltransferase activity13
GO:0043065positive regulation of apoptotic process7202
GO:0007218neuropeptide signaling pathway253
GO:0045087innate immune response12452
GO:1900035negative regulation of cellular response to heat11
GO:0009612response to mechanical stimulus246
GO:0070933histone H4 deacetylation111
GO:0071665gamma-catenin-TCF7L2 complex11
GO:0032855positive regulation of Rac GTPase activity124
GO:0016032viral process30428
GO:0001666response to hypoxia2116
GO:0002943tRNA dihydrouridine synthesis13
GO:0008022protein C-terminus binding5115
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress120
GO:2000781positive regulation of double-strand break repair12
GO:0006367transcription initiation from RNA polymerase II promoter18161
GO:0031616spindle pole centrosome15
GO:0045120pronucleus311
GO:0000976transcription regulatory region sequence-specific DNA binding325
GO:0035556intracellular signal transduction5199
GO:0001934positive regulation of protein phosphorylation183
GO:0006470protein dephosphorylation261
GO:0005871kinesin complex331
GO:0043085positive regulation of catalytic activity245
GO:0004298threonine-type endopeptidase activity117
GO:0002039p53 binding445
GO:0001533cornified envelope113
GO:0019992diacylglycerol binding16
GO:0000800lateral element15
GO:0006366transcription from RNA polymerase II promoter23341
GO:00427915S class rRNA transcription from RNA polymerase III type 1 promoter35
GO:0006424glutamyl-tRNA aminoacylation12
GO:0043401steroid hormone mediated signaling pathway147
GO:0044089positive regulation of cellular component biogenesis11
GO:00163091-phosphatidylinositol-5-phosphate 4-kinase activity11
GO:0031116positive regulation of microtubule polymerization18
GO:0034644cellular response to UV128
GO:0008307structural constituent of muscle222
GO:0010832negative regulation of myotube differentiation16
GO:0042826histone deacetylase binding558
GO:0043995histone acetyltransferase activity (H4-K5 specific)13
GO:0045494photoreceptor cell maintenance117
GO:0032784regulation of DNA-templated transcription, elongation27
GO:0010458exit from mitosis25
GO:0031080nuclear pore outer ring29
GO:0016149translation release factor activity, codon specific11
GO:0000502proteasome complex347
GO:0000122negative regulation of transcription from RNA polymerase II promoter29456
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation117
GO:0040016embryonic cleavage15
GO:0048265response to pain116
GO:0043202lysosomal lumen139
GO:0043525positive regulation of neuron apoptotic process141
GO:0050900leukocyte migration291
GO:0005758mitochondrial intermembrane space448
GO:0008281sulfonylurea receptor activity11
GO:0051090regulation of sequence-specific DNA binding transcription factor activity218
GO:0032526response to retinoic acid138
GO:0032869cellular response to insulin stimulus247
GO:0006464cellular protein modification process461
GO:2001244positive regulation of intrinsic apoptotic signaling pathway128
GO:0043537negative regulation of blood vessel endothelial cell migration19
GO:0007259JAK-STAT cascade225
GO:0006283transcription-coupled nucleotide-excision repair640
GO:0042127regulation of cell proliferation480
GO:0017148negative regulation of translation533
GO:0043558regulation of translational initiation in response to stress12
GO:0005507copper ion binding129
GO:0071902positive regulation of protein serine/threonine kinase activity220
GO:2000147positive regulation of cell motility27
GO:2000427positive regulation of apoptotic cell clearance14
GO:0032981mitochondrial respiratory chain complex I assembly19
GO:0042101T cell receptor complex111
GO:0044822poly(A) RNA binding45799
GO:0031307integral component of mitochondrial outer membrane115
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity330
GO:0010039response to iron ion18
GO:0010628positive regulation of gene expression2106
GO:0071880adenylate cyclase-activating adrenergic receptor signaling pathway12
GO:0035249synaptic transmission, glutamatergic120
GO:0008380RNA splicing21165
GO:0045787positive regulation of cell cycle119
GO:0008143poly(A) binding210
GO:0003723RNA binding22247
GO:0016576histone dephosphorylation13
GO:0005741mitochondrial outer membrane279
GO:0032289central nervous system myelin formation13
GO:0060510Type II pneumocyte differentiation15
GO:0043982histone H4-K8 acetylation17
GO:0060992response to fungicide24
GO:0015036disulfide oxidoreductase activity11
GO:0004535poly(A)-specific ribonuclease activity18
GO:0006694steroid biosynthetic process115
GO:0071168protein localization to chromatin25
GO:0010165response to X-ray217
GO:0033160positive regulation of protein import into nucleus, translocation110
GO:0061024membrane organization289
GO:0009925basal plasma membrane123
GO:0001827inner cell mass cell fate commitment11
GO:0005719nuclear euchromatin216
GO:1990046stress-induced mitochondrial fusion11
GO:0018963phthalate metabolic process15
GO:0014835myoblast differentiation involved in skeletal muscle regeneration11
GO:2000036regulation of stem cell maintenance111
GO:0043006activation of phospholipase A2 activity by calcium-mediated signaling12
GO:0030433ER-associated ubiquitin-dependent protein catabolic process122
GO:0007154cell communication111
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex25
GO:2000481positive regulation of cAMP-dependent protein kinase activity14
GO:0043691reverse cholesterol transport114
GO:0030241skeletal muscle myosin thick filament assembly12
GO:0005929cilium247
GO:0006333chromatin assembly or disassembly14
GO:0005643nuclear pore1251
GO:0034614cellular response to reactive oxygen species29
GO:0075713establishment of integrated proviral latency18
GO:0010793regulation of mRNA export from nucleus13
GO:0003674molecular_function4297
GO:0035097histone methyltransferase complex110
GO:0006511ubiquitin-dependent protein catabolic process692
GO:0043967histone H4 acetylation122
GO:0001776leukocyte homeostasis11
GO:0033290eukaryotic 48S preinitiation complex111
GO:0043565sequence-specific DNA binding8275
GO:0070131positive regulation of mitochondrial translation12
GO:0005098Ran GTPase activator activity11
GO:0007254JNK cascade134
GO:0010288response to lead ion18
GO:0008242omega peptidase activity18
GO:0005726perichromatin fibrils13
GO:0006376mRNA splice site selection19
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway355
GO:0005838proteasome regulatory particle110
GO:0006687glycosphingolipid metabolic process122
GO:0034048negative regulation of protein phosphatase type 2A activity12
GO:0006352DNA-templated transcription, initiation315
GO:0005515protein binding1984124
GO:0022904respiratory electron transport chain354
GO:0038001paracrine signaling12
GO:0006564L-serine biosynthetic process14
GO:0000777condensed chromosome kinetochore657
GO:0007411axon guidance8237
GO:0006998nuclear envelope organization17
GO:0070734histone H3-K27 methylation14
GO:0006778porphyrin-containing compound metabolic process212
GO:0006936muscle contraction554
GO:0030670phagocytic vesicle membrane130
GO:0070830tight junction assembly129
GO:0061028establishment of endothelial barrier110
GO:0045174glutathione dehydrogenase (ascorbate) activity12
GO:0004519endonuclease activity113
GO:0000059protein import into nucleus, docking12
GO:0005657replication fork316
GO:0051897positive regulation of protein kinase B signaling162
GO:0005487nucleocytoplasmic transporter activity211
GO:0070849response to epidermal growth factor14
GO:0019887protein kinase regulator activity23
GO:0005853eukaryotic translation elongation factor 1 complex13
GO:0042581specific granule17
GO:0051604protein maturation18
GO:0051138positive regulation of NK T cell differentiation15
GO:0031424keratinization223
GO:0005085guanyl-nucleotide exchange factor activity243
GO:0005737cytoplasm1272633
GO:0001892embryonic placenta development120
GO:0003407neural retina development24
GO:0006914autophagy144
GO:0072011glomerular endothelium development13
GO:0035759mesangial cell-matrix adhesion11
GO:0048754branching morphogenesis of an epithelial tube123
GO:0006006glucose metabolic process380
GO:0018964propylene metabolic process11
GO:0009635response to herbicide15
GO:0090263positive regulation of canonical Wnt signaling pathway236
GO:0005845mRNA cap binding complex18
GO:0043566structure-specific DNA binding16
GO:0016581NuRD complex114
GO:0016055Wnt signaling pathway687
GO:0030240skeletal muscle thin filament assembly14
GO:0000287magnesium ion binding4115
GO:0005840ribosome240
GO:0097192extrinsic apoptotic signaling pathway in absence of ligand131
GO:0072429response to intra-S DNA damage checkpoint signaling13
GO:1901673regulation of spindle assembly involved in mitosis11
GO:0008202steroid metabolic process141
GO:0051010microtubule plus-end binding211
GO:0000165MAPK cascade358
GO:0030488tRNA methylation29
GO:0030854positive regulation of granulocyte differentiation16
GO:0042307positive regulation of protein import into nucleus312
GO:0048599oocyte development16
GO:0016925protein sumoylation322
GO:0030049muscle filament sliding219
GO:0016023cytoplasmic membrane-bounded vesicle163
GO:0050728negative regulation of inflammatory response149
GO:0002576platelet degranulation362
GO:0006362transcription elongation from RNA polymerase I promoter320
GO:0007080mitotic metaphase plate congression111
GO:0007173epidermal growth factor receptor signaling pathway5142
GO:0042585germinal vesicle23
GO:0009378four-way junction helicase activity12
GO:0044030regulation of DNA methylation14
GO:0004383guanylate cyclase activity16
GO:0042493response to drug4222
GO:0043524negative regulation of neuron apoptotic process285
GO:0061098positive regulation of protein tyrosine kinase activity118
GO:0050772positive regulation of axonogenesis213
GO:0005828kinetochore microtubule15
GO:0021938smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation14
GO:0007631feeding behavior117
GO:0070588calcium ion transmembrane transport170
GO:0006986response to unfolded protein135
GO:0008353RNA polymerase II carboxy-terminal domain kinase activity111
GO:0060316positive regulation of ryanodine-sensitive calcium-release channel activity17
GO:0000737DNA catabolic process, endonucleolytic229
GO:0034138toll-like receptor 3 signaling pathway259
GO:0017034Rap guanyl-nucleotide exchange factor activity13
GO:0005666DNA-directed RNA polymerase III complex313
GO:0030177positive regulation of Wnt signaling pathway123
GO:0006383transcription from RNA polymerase III promoter629
GO:2001224positive regulation of neuron migration16
GO:0051533positive regulation of NFAT protein import into nucleus13
GO:0008286insulin receptor signaling pathway297
GO:0048011neurotrophin TRK receptor signaling pathway8199
GO:0007067mitotic nuclear division9165
GO:0000792heterochromatin117
GO:0030968endoplasmic reticulum unfolded protein response161
GO:0019933cAMP-mediated signaling117
GO:0065002intracellular protein transmembrane transport13
GO:0045662negative regulation of myoblast differentiation18
GO:0001975response to amphetamine123
GO:0001764neuron migration167
GO:0006346methylation-dependent chromatin silencing16
GO:0010827regulation of glucose transport725
GO:0002176male germ cell proliferation12
GO:0019395fatty acid oxidation18
GO:0070937CRD-mediated mRNA stability complex26
GO:0016446somatic hypermutation of immunoglobulin genes16
GO:0019825oxygen binding128
GO:0051488activation of anaphase-promoting complex activity15
GO:0005875microtubule associated complex122
GO:0005576extracellular region15663
GO:0005246calcium channel regulator activity110
GO:0006404RNA import into nucleus11
GO:1900221regulation of beta-amyloid clearance12
GO:0008156negative regulation of DNA replication113
GO:0000722telomere maintenance via recombination122
GO:0050610methylarsonate reductase activity12
GO:0032868response to insulin139
GO:0031435mitogen-activated protein kinase kinase kinase binding118
GO:2000178negative regulation of neural precursor cell proliferation15
GO:0045664regulation of neuron differentiation110
GO:0042803protein homodimerization activity13428
GO:0016342catenin complex17
GO:0004527exonuclease activity412
GO:0051082unfolded protein binding570
GO:0005905coated pit237
GO:0009615response to virus397
GO:0070840dynein complex binding12
GO:0060170ciliary membrane119
GO:0001054RNA polymerase I activity410
GO:0070182DNA polymerase binding18
GO:0000932cytoplasmic mRNA processing body343
GO:0001502cartilage condensation213
GO:0045739positive regulation of DNA repair318
GO:0051101regulation of DNA binding15
GO:0035457cellular response to interferon-alpha18
GO:0003700sequence-specific DNA binding transcription factor activity22582
GO:0001047core promoter binding442
GO:0035176social behavior128
GO:1901216positive regulation of neuron death17
GO:0051592response to calcium ion137
GO:0061003positive regulation of dendritic spine morphogenesis15
GO:0043623cellular protein complex assembly114
GO:0097363protein O-GlcNAc transferase activity11
GO:0035987endodermal cell differentiation120
GO:0016050vesicle organization19
GO:0032261purine nucleotide salvage11
GO:0004866endopeptidase inhibitor activity119
GO:0010815bradykinin catabolic process14
GO:0002020protease binding350
GO:0040029regulation of gene expression, epigenetic110
GO:0007585respiratory gaseous exchange125
GO:0000187activation of MAPK activity363
GO:0090023positive regulation of neutrophil chemotaxis114
GO:0046626regulation of insulin receptor signaling pathway11
GO:0039534negative regulation of MDA-5 signaling pathway12
GO:0043503skeletal muscle fiber adaptation12
GO:0016595glutamate binding18
GO:0009986cell surface5291
GO:0042692muscle cell differentiation228
GO:0003713transcription coactivator activity21184
GO:0031466Cul5-RING ubiquitin ligase complex16
GO:0000794condensed nuclear chromosome118
GO:0019079viral genome replication17
GO:0019903protein phosphatase binding247
GO:0007166cell surface receptor signaling pathway389
GO:0008584male gonad development157
GO:0007269neurotransmitter secretion130
GO:0007625grooming behavior19
GO:0016605PML body579
GO:0005675holo TFIIH complex18
GO:0080129proteasome core complex assembly11
GO:0007079mitotic chromosome movement towards spindle pole12
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process167
GO:0000799nuclear condensin complex11
GO:0001103RNA polymerase II repressing transcription factor binding223
GO:1901888regulation of cell junction assembly12
GO:0043388positive regulation of DNA binding221
GO:0044295axonal growth cone19
GO:0005088Ras guanyl-nucleotide exchange factor activity13
GO:0034080CENP-A containing nucleosome assembly220
GO:0001942hair follicle development221
GO:0050862positive regulation of T cell receptor signaling pathway14
GO:0018160peptidyl-pyrromethane cofactor linkage11
GO:0038066p38MAPK cascade11
GO:0033234negative regulation of protein sumoylation15
GO:0070742C2H2 zinc finger domain binding115
GO:0006301postreplication repair27
GO:0051259protein oligomerization329
GO:0055010ventricular cardiac muscle tissue morphogenesis120
GO:0045740positive regulation of DNA replication132
GO:0045296cadherin binding220
GO:0006182cGMP biosynthetic process110
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding121
GO:0030900forebrain development236
GO:0050885neuromuscular process controlling balance128
GO:0003747translation release factor activity22
GO:0043297apical junction assembly16
GO:0015074DNA integration15
GO:0030331estrogen receptor binding222
GO:0005796Golgi lumen152
GO:0017183peptidyl-diphthamide biosynthetic process from peptidyl-histidine15
GO:0071407cellular response to organic cyclic compound234
GO:0070345negative regulation of fat cell proliferation12
GO:0035710CD4-positive, alpha-beta T cell activation12
GO:0045202synapse383
GO:0035402histone kinase activity (H3-T11 specific)11
GO:0004402histone acetyltransferase activity330
GO:0005001transmembrane receptor protein tyrosine phosphatase activity115
GO:0030485smooth muscle contractile fiber13
GO:0001731formation of translation preinitiation complex314
GO:0008821crossover junction endodeoxyribonuclease activity14
GO:0031091platelet alpha granule18
GO:0070273phosphatidylinositol-4-phosphate binding19
GO:0006887exocytosis144
GO:0007095mitotic G2 DNA damage checkpoint213
GO:0048365Rac GTPase binding219
GO:0090090negative regulation of canonical Wnt signaling pathway559
GO:0000055ribosomal large subunit export from nucleus14
GO:0048541Peyer's patch development27
GO:0006282regulation of DNA repair25
GO:0033688regulation of osteoblast proliferation12
GO:0006363termination of RNA polymerase I transcription321
GO:0005925focal adhesion14282
GO:0032057negative regulation of translational initiation in response to stress14
GO:0031690adrenergic receptor binding11
GO:0042752regulation of circadian rhythm529
GO:0001708cell fate specification115
GO:0009954proximal/distal pattern formation217
GO:0010870positive regulation of receptor biosynthetic process17
GO:0036124histone H3-K9 trimethylation24
GO:0007094mitotic spindle assembly checkpoint425
GO:0071204histone pre-mRNA 3'end processing complex15
GO:00084083'-5' exonuclease activity111
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway127
GO:0001159core promoter proximal region DNA binding11
GO:0043434response to peptide hormone136
GO:0031453positive regulation of heterochromatin assembly11
GO:00080975S rRNA binding12
GO:0048256flap endonuclease activity11
GO:0045444fat cell differentiation136
GO:0031966mitochondrial membrane135
GO:0032201telomere maintenance via semi-conservative replication120
GO:0070534protein K63-linked ubiquitination324
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity159
GO:0090316positive regulation of intracellular protein transport111
GO:0060444branching involved in mammary gland duct morphogenesis110
GO:0016874ligase activity11146
GO:0048730epidermis morphogenesis15
GO:0005094Rho GDP-dissociation inhibitor activity13
GO:0009991response to extracellular stimulus13
GO:0005815microtubule organizing center477
GO:0015630microtubule cytoskeleton575
GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine14
GO:0043425bHLH transcription factor binding120
GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process17
GO:0055086nucleobase-containing small molecule metabolic process251
GO:0007052mitotic spindle organization317
GO:0045880positive regulation of smoothened signaling pathway115
GO:0032993protein-DNA complex113
GO:0006833water transport123
GO:0030674protein binding, bridging137
GO:0030099myeloid cell differentiation115
GO:1990023mitotic spindle midzone14
GO:0046930pore complex18
GO:1990090cellular response to nerve growth factor stimulus111
GO:0010831positive regulation of myotube differentiation16
GO:0051879Hsp90 protein binding114
GO:0000281mitotic cytokinesis315
GO:0006897endocytosis267
GO:0000266mitochondrial fission211
GO:0008469histone-arginine N-methyltransferase activity13
GO:0060205cytoplasmic membrane-bounded vesicle lumen12
GO:2000379positive regulation of reactive oxygen species metabolic process121
GO:0007070negative regulation of transcription from RNA polymerase II promoter during mitosis12
GO:0032495response to muramyl dipeptide18
GO:0016779nucleotidyltransferase activity14
GO:0033089positive regulation of T cell differentiation in thymus15
GO:0042626ATPase activity, coupled to transmembrane movement of substances125
GO:0034707chloride channel complex124
GO:0031547brain-derived neurotrophic factor receptor signaling pathway12
GO:0005351sugar:proton symporter activity13
GO:0048511rhythmic process538
GO:0030425dendrite2166
GO:0032872regulation of stress-activated MAPK cascade17
GO:0001967suckling behavior410
GO:0032588trans-Golgi network membrane129
GO:0010748negative regulation of plasma membrane long-chain fatty acid transport14
GO:0030858positive regulation of epithelial cell differentiation16
GO:0032091negative regulation of protein binding128
GO:0002199zona pellucida receptor complex47
GO:0042110T cell activation233
GO:0006094gluconeogenesis131
GO:0008021synaptic vesicle240
GO:0030027lamellipodium388
GO:0043005neuron projection6113
GO:0048476Holliday junction resolvase complex12
GO:0034332adherens junction organization128
GO:0006606protein import into nucleus322
GO:0006396RNA processing440
GO:0003688DNA replication origin binding13
GO:0006430lysyl-tRNA aminoacylation11
GO:0007059chromosome segregation450
GO:0006521regulation of cellular amino acid metabolic process241
GO:2000134negative regulation of G1/S transition of mitotic cell cycle215
GO:1900026positive regulation of substrate adhesion-dependent cell spreading116
GO:0035615clathrin adaptor activity17
GO:0005975carbohydrate metabolic process10186
GO:0007026negative regulation of microtubule depolymerization211
GO:0006611protein export from nucleus118
GO:0000786nucleosome234
GO:0006471protein ADP-ribosylation110
GO:0017075syntaxin-1 binding113
GO:0008135translation factor activity, nucleic acid binding415
GO:0004867serine-type endopeptidase inhibitor activity142
GO:0030122AP-2 adaptor complex29
GO:0033182regulation of histone ubiquitination11
GO:0006953acute-phase response224
GO:0006337nucleosome disassembly213
GO:0061136regulation of proteasomal protein catabolic process19
GO:0086014atrial cardiac muscle cell action potential15
GO:0031297replication fork processing19
GO:0060548negative regulation of cell death119
GO:0043021ribonucleoprotein complex binding117
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity141
GO:0005881cytoplasmic microtubule324
GO:0050660flavin adenine dinucleotide binding138
GO:0035404histone-serine phosphorylation13
GO:0004722protein serine/threonine phosphatase activity128
GO:0031990mRNA export from nucleus in response to heat stress12
GO:0030173integral component of Golgi membrane123
GO:0015030Cajal body332
GO:0051156glucose 6-phosphate metabolic process16
GO:0016301kinase activity230
GO:0070979protein K11-linked ubiquitination320
GO:0032854positive regulation of Rap GTPase activity17
GO:0070934CRD-mediated mRNA stabilization25
GO:0045121membrane raft1124
GO:0030056hemidesmosome17
GO:00709353'-UTR-mediated mRNA stabilization111
GO:0035235ionotropic glutamate receptor signaling pathway117
GO:0086005ventricular cardiac muscle cell action potential110
GO:0005201extracellular matrix structural constituent137
GO:0072659protein localization to plasma membrane124
GO:0001889liver development471
GO:0001726ruffle253
GO:0046974histone methyltransferase activity (H3-K9 specific)16
GO:0045910negative regulation of DNA recombination17
GO:0044325ion channel binding252
GO:0060509Type I pneumocyte differentiation16
GO:0006644phospholipid metabolic process189
GO:0006955immune response2200
GO:0007268synaptic transmission7214
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway120
GO:0016020membrane561207
GO:2000045regulation of G1/S transition of mitotic cell cycle111
GO:0019788NEDD8 ligase activity14
GO:0042472inner ear morphogenesis137
GO:0032059bleb15
GO:0030071regulation of mitotic metaphase/anaphase transition24
GO:0009611response to wounding241
GO:0090170regulation of Golgi inheritance14
GO:0003954NADH dehydrogenase activity14
GO:0016337single organismal cell-cell adhesion362
GO:0000077DNA damage checkpoint421
GO:0045648positive regulation of erythrocyte differentiation217
GO:0050771negative regulation of axonogenesis214
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway121
GO:0070087chromo shadow domain binding16
GO:0035887aortic smooth muscle cell differentiation22
GO:0043631RNA polyadenylation14
GO:0034097response to cytokine140
GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum111
GO:0071313cellular response to caffeine15
GO:0016328lateral plasma membrane231
GO:0031372UBC13-MMS2 complex12
GO:0009982pseudouridine synthase activity110
GO:1900038negative regulation of cellular response to hypoxia11
GO:0042924neuromedin U binding11
GO:0007608sensory perception of smell227
GO:0009566fertilization118
GO:2000001regulation of DNA damage checkpoint13
GO:0017166vinculin binding110
GO:0006493protein O-linked glycosylation18
GO:0043140ATP-dependent 3'-5' DNA helicase activity15
GO:0016477cell migration396
GO:0071260cellular response to mechanical stimulus255
GO:0071459protein localization to chromosome, centromeric region13
GO:0045786negative regulation of cell cycle330
GO:0040008regulation of growth137
GO:0047485protein N-terminus binding665
GO:0006302double-strand break repair552
GO:0048016inositol phosphate-mediated signaling17
GO:0030018Z disc364
GO:0006903vesicle targeting16
GO:0033683nucleotide-excision repair, DNA incision13
GO:0070301cellular response to hydrogen peroxide135
GO:0001935endothelial cell proliferation111
GO:0061087positive regulation of histone H3-K27 methylation14
GO:0045862positive regulation of proteolysis317
GO:0043203axon hillock15
GO:0006468protein phosphorylation6301
GO:0090399replicative senescence17
GO:0005694chromosome455
GO:0006886intracellular protein transport289
GO:0045725positive regulation of glycogen biosynthetic process111
GO:0031681G-protein beta-subunit binding15
GO:0008047enzyme activator activity227
GO:0060041retina development in camera-type eye134
GO:0009952anterior/posterior pattern specification360
GO:0045116protein neddylation17
GO:0010629negative regulation of gene expression162
GO:0071320cellular response to cAMP133
GO:0007050cell cycle arrest492
GO:0007100mitotic centrosome separation22
GO:0006937regulation of muscle contraction19
GO:0060216definitive hemopoiesis113
GO:0030097hemopoiesis348
GO:0010001glial cell differentiation111
GO:0004407histone deacetylase activity112
GO:0042483negative regulation of odontogenesis11
GO:0034366spherical high-density lipoprotein particle17
GO:00431395'-3' DNA helicase activity13
GO:0017146N-methyl-D-aspartate selective glutamate receptor complex18
GO:0046872metal ion binding24934
GO:0044297cell body535
GO:0001948glycoprotein binding137
GO:0043101purine-containing compound salvage18
GO:0032456endocytic recycling28
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest353
GO:0034660ncRNA metabolic process120
GO:0045295gamma-catenin binding19
GO:0032481positive regulation of type I interferon production348
GO:0007596blood coagulation13339
GO:0051896regulation of protein kinase B signaling17
GO:0030274LIM domain binding15
GO:0021987cerebral cortex development230
GO:0046685response to arsenic-containing substance18
GO:0035326enhancer binding111
GO:0005736DNA-directed RNA polymerase I complex410
GO:0043950positive regulation of cAMP-mediated signaling111
GO:0000189MAPK import into nucleus12
GO:0034446substrate adhesion-dependent cell spreading225
GO:0042802identical protein binding15354
GO:0006334nucleosome assembly451
GO:0033598mammary gland epithelial cell proliferation19
GO:0048545response to steroid hormone213
GO:0007155cell adhesion8244
GO:0010997anaphase-promoting complex binding13
GO:0031592centrosomal corona11
GO:0032733positive regulation of interleukin-10 production213
GO:0017091AU-rich element binding213
GO:0097165nuclear stress granule11
GO:0003094glomerular filtration18
GO:0046641positive regulation of alpha-beta T cell proliferation18
GO:1900168positive regulation of glial cell line-derived neurotrophic factor secretion11
GO:0005859muscle myosin complex15
GO:0045773positive regulation of axon extension111
GO:0015760glucose-6-phosphate transport13
GO:0005516calmodulin binding499
GO:0031012extracellular matrix4107
GO:1903506regulation of nucleic acid-templated transcription216
GO:1903377negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway14
GO:0004725protein tyrosine phosphatase activity149
GO:0045669positive regulation of osteoblast differentiation241
GO:0018958phenol-containing compound metabolic process14
GO:0006271DNA strand elongation involved in DNA replication129
GO:0000439core TFIIH complex15
GO:0043130ubiquitin binding330
GO:0000086G2/M transition of mitotic cell cycle797
GO:2000615regulation of histone H3-K9 acetylation11
GO:0018206peptidyl-methionine modification14
GO:0031062positive regulation of histone methylation13
GO:0030449regulation of complement activation214
GO:0010951negative regulation of endopeptidase activity271
GO:0007016cytoskeletal anchoring at plasma membrane111
GO:0045292mRNA cis splicing, via spliceosome14
GO:0006661phosphatidylinositol biosynthetic process135
GO:0045778positive regulation of ossification18
GO:0005684U2-type spliceosomal complex22
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic119
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)19
GO:0032729positive regulation of interferon-gamma production128
GO:0002326B cell lineage commitment14
GO:0030981cortical microtubule cytoskeleton12
GO:0001725stress fiber646
GO:0051171regulation of nitrogen compound metabolic process11
GO:1902949positive regulation of tau-protein kinase activity11
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent257
GO:0005215transporter activity582
GO:0071344diphosphate metabolic process11
GO:0005777peroxisome250
GO:0001824blastocyst development112
GO:0002636positive regulation of germinal center formation13
GO:0071657positive regulation of granulocyte colony-stimulating factor production12
GO:0042178xenobiotic catabolic process13
GO:0004013adenosylhomocysteinase activity11
GO:0072562blood microparticle481
GO:0021740principal sensory nucleus of trigeminal nerve development11
GO:0048538thymus development125
GO:0048741skeletal muscle fiber development111
GO:0051496positive regulation of stress fiber assembly226
GO:0006928cellular component movement670
GO:0007204positive regulation of cytosolic calcium ion concentration164
GO:0000723telomere maintenance247
GO:0046966thyroid hormone receptor binding320
GO:0000303response to superoxide14
GO:0003136negative regulation of heart induction by canonical Wnt signaling pathway13
GO:0009898cytoplasmic side of plasma membrane328
GO:0000940condensed chromosome outer kinetochore16
GO:0000123histone acetyltransferase complex18
GO:0051457maintenance of protein location in nucleus17
GO:0006457protein folding597
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding7142
GO:0003729mRNA binding457
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity314
GO:0042475odontogenesis of dentin-containing tooth240
GO:0002062chondrocyte differentiation222
GO:0035303regulation of dephosphorylation12
GO:0006412translation12178
GO:0034260negative regulation of GTPase activity17
GO:0043536positive regulation of blood vessel endothelial cell migration114
GO:0005459UDP-galactose transmembrane transporter activity11
GO:0004222metalloendopeptidase activity164
GO:0006999nuclear pore organization14
GO:0032286central nervous system myelin maintenance12
GO:0030521androgen receptor signaling pathway335
GO:0006110regulation of glycolytic process14
GO:0030135coated vesicle13
GO:0030371translation repressor activity15
GO:0006633fatty acid biosynthetic process126
GO:0030308negative regulation of cell growth370
GO:0043034costamere215
GO:0045214sarcomere organization113
GO:0034605cellular response to heat122
GO:0004109coproporphyrinogen oxidase activity11
GO:0045839negative regulation of mitosis16
GO:0031492nucleosomal DNA binding325
GO:0031994insulin-like growth factor I binding17
GO:0034329cell junction assembly253
GO:0005874microtubule10163
GO:0031340positive regulation of vesicle fusion15
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)19
GO:0019068virion assembly17
GO:0046578regulation of Ras protein signal transduction16
GO:0016887ATPase activity5100
GO:0072686mitotic spindle220
GO:0022624proteasome accessory complex114
GO:0005782peroxisomal matrix116
GO:0006816calcium ion transport153
GO:0008035high-density lipoprotein particle binding16
GO:0019827stem cell maintenance439
GO:0003684damaged DNA binding141
GO:0016575histone deacetylation214
GO:0032486Rap protein signal transduction17
GO:2001275positive regulation of glucose import in response to insulin stimulus13
GO:0004523RNA-DNA hybrid ribonuclease activity15
GO:0042382paraspeckles35
GO:0046540U4/U6 x U5 tri-snRNP complex14
GO:0048593camera-type eye morphogenesis113
GO:0012505endomembrane system234
GO:0002102podosome112
GO:0004252serine-type endopeptidase activity178
GO:0046827positive regulation of protein export from nucleus111
GO:0010212response to ionizing radiation330
GO:0008308voltage-gated anion channel activity14
GO:0033558protein deacetylase activity18
GO:0000125PCAF complex15
GO:0007176regulation of epidermal growth factor-activated receptor activity14
GO:0031016pancreas development116
GO:0048133male germ-line stem cell asymmetric division13
GO:0031667response to nutrient levels217
GO:0051754meiotic sister chromatid cohesion, centromeric11
GO:0009948anterior/posterior axis specification18
GO:0008233peptidase activity228
GO:0004672protein kinase activity5125
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway131
GO:0042273ribosomal large subunit biogenesis111
GO:0030203glycosaminoglycan metabolic process153
GO:0006386termination of RNA polymerase III transcription314
GO:0032000positive regulation of fatty acid beta-oxidation17
GO:0009953dorsal/ventral pattern formation218
GO:0045599negative regulation of fat cell differentiation229
GO:0046970NAD-dependent histone deacetylase activity (H4-K16 specific)19
GO:0005978glycogen biosynthetic process215
GO:0071681cellular response to indole-3-methanol15
GO:0017150tRNA dihydrouridine synthase activity13
GO:0045663positive regulation of myoblast differentiation29
GO:0051716cellular response to stimulus12
GO:0005577fibrinogen complex16
GO:0035329hippo signaling119
GO:0008074guanylate cyclase complex, soluble12
GO:0042405nuclear inclusion body18
GO:0030496midbody673
GO:0019897extrinsic component of plasma membrane114
GO:0006702androgen biosynthetic process18
GO:0015631tubulin binding120
GO:0016574histone ubiquitination14
GO:0005886plasma membrane461784
GO:0050776regulation of immune response255
GO:0000226microtubule cytoskeleton organization136
GO:0035254glutamate receptor binding14
GO:0097153cysteine-type endopeptidase activity involved in apoptotic process15
GO:0051591response to cAMP132
GO:0006306DNA methylation119
GO:0005902microvillus125
GO:0008645hexose transport836
GO:0090307spindle assembly involved in mitosis28
GO:0005509calcium ion binding9351
GO:0002755MyD88-dependent toll-like receptor signaling pathway461
GO:0016324apical plasma membrane2147
GO:0097190apoptotic signaling pathway183
GO:0043486histone exchange13
GO:0033622integrin activation13
GO:0043578nuclear matrix organization11
GO:0030864cortical actin cytoskeleton116
GO:0010906regulation of glucose metabolic process113
GO:0030892mitotic cohesin complex12
GO:0002098tRNA wobble uridine modification13
GO:0035519protein K29-linked ubiquitination25
GO:0032320positive regulation of Ras GTPase activity218
GO:0060390regulation of SMAD protein import into nucleus11
GO:004744217-alpha-hydroxyprogesterone aldolase activity11
GO:1901215negative regulation of neuron death120
GO:0046580negative regulation of Ras protein signal transduction114
GO:0030100regulation of endocytosis19
GO:00063707-methylguanosine mRNA capping524
GO:0006403RNA localization12
GO:0032332positive regulation of chondrocyte differentiation111
GO:0051924regulation of calcium ion transport115
GO:0010876lipid localization11
GO:0007584response to nutrient144
GO:0060028convergent extension involved in axis elongation12
GO:0016592mediator complex625
GO:2000795negative regulation of epithelial cell proliferation involved in lung morphogenesis11
GO:0010965regulation of mitotic sister chromatid separation11
GO:0070309lens fiber cell morphogenesis13
GO:0031093platelet alpha granule lumen335
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process156
GO:0071817MMXD complex24
GO:0006892post-Golgi vesicle-mediated transport132
GO:0002076osteoblast development115
GO:0005665DNA-directed RNA polymerase II, core complex313
GO:0061042vascular wound healing13
GO:0006361transcription initiation from RNA polymerase I promoter223
GO:0086069bundle of His cell to Purkinje myocyte communication15
GO:0051216cartilage development136
GO:0010569regulation of double-strand break repair via homologous recombination19
GO:0051435BH4 domain binding11
GO:0003743translation initiation factor activity837
GO:0005913cell-cell adherens junction325
GO:0001837epithelial to mesenchymal transition127
GO:0042306regulation of protein import into nucleus12
GO:0016746transferase activity, transferring acyl groups214
GO:0043249erythrocyte maturation19
GO:0016580Sin3 complex111
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-proline15
GO:0060744mammary gland branching involved in thelarche15
GO:0006915apoptotic process15411
GO:0060290transdifferentiation15
GO:0048469cell maturation131
GO:0060070canonical Wnt signaling pathway151
GO:0031571mitotic G1 DNA damage checkpoint19
GO:0070990snRNP binding11
GO:0014065phosphatidylinositol 3-kinase signaling116
GO:0009636response to toxic substance150
GO:0070688MLL5-L complex16
GO:0051880G-quadruplex DNA binding15
GO:0071949FAD binding18
GO:0032927positive regulation of activin receptor signaling pathway15
GO:0033503HULC complex14
GO:0008088axon cargo transport18
GO:0006438valyl-tRNA aminoacylation11
GO:0042383sarcolemma141
GO:0071805potassium ion transmembrane transport157
GO:0002686negative regulation of leukocyte migration13
GO:0008168methyltransferase activity230
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay18
GO:0010332response to gamma radiation226
GO:0046326positive regulation of glucose import122
GO:0004713protein tyrosine kinase activity155
GO:0044300cerebellar mossy fiber14
GO:0071565nBAF complex311
GO:0051721protein phosphatase 2A binding114
GO:0072583clathrin-mediated endocytosis19
GO:0090233negative regulation of spindle checkpoint11
GO:0031058positive regulation of histone modification11
GO:0008015blood circulation131
GO:2001235positive regulation of apoptotic signaling pathway219
GO:0035914skeletal muscle cell differentiation333
GO:0004767sphingomyelin phosphodiesterase activity13
GO:0048566embryonic digestive tract development19
GO:0019221cytokine-mediated signaling pathway10172
GO:0000421autophagic vacuole membrane113
GO:0005635nuclear envelope683
GO:0003950NAD+ ADP-ribosyltransferase activity113
GO:0051788response to misfolded protein13
GO:0046832negative regulation of RNA export from nucleus12
GO:0006987activation of signaling protein activity involved in unfolded protein response147
GO:0016010dystrophin-associated glycoprotein complex110
GO:0006281DNA repair24203
GO:0005057receptor signaling protein activity226
GO:0050852T cell receptor signaling pathway268
GO:0019950SMT3-dependent protein catabolic process12
GO:0001669acrosomal vesicle128
GO:0031023microtubule organizing center organization15
GO:0060134prepulse inhibition18
GO:0038095Fc-epsilon receptor signaling pathway2132
GO:0019153protein-disulfide reductase (glutathione) activity11
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening19
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic221
GO:0034504protein localization to nucleus122
GO:0071526semaphorin-plexin signaling pathway113
GO:0097371MDM2/MDM4 family protein binding15
GO:0031625ubiquitin protein ligase binding7138
GO:0005850eukaryotic translation initiation factor 2 complex23
GO:0071603endothelial cell-cell adhesion12
GO:0034696response to prostaglandin F12
GO:0060271cilium morphogenesis126
GO:0030544Hsp70 protein binding112
GO:0015031protein transport10203
GO:0008285negative regulation of cell proliferation11277
GO:0006956complement activation220
GO:0034389lipid particle organization19
GO:0003899DNA-directed RNA polymerase activity318
GO:0048022negative regulation of melanin biosynthetic process11
GO:0070244negative regulation of thymocyte apoptotic process25
GO:0051056regulation of small GTPase mediated signal transduction276
GO:0052565response to defense-related host nitric oxide production11
GO:0007141male meiosis I110
GO:0001503ossification256
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion112
GO:0045840positive regulation of mitosis120
GO:0035851Krueppel-associated box domain binding12
GO:0007569cell aging121
GO:0021930cerebellar granule cell precursor proliferation14
GO:0021707cerebellar granule cell differentiation16
GO:0021696cerebellar cortex morphogenesis15
GO:0070181small ribosomal subunit rRNA binding11
GO:0043234protein complex13210
GO:0001832blastocyst growth12
GO:0006338chromatin remodeling755
GO:0097191extrinsic apoptotic signaling pathway130
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription4132
GO:0070314G1 to G0 transition13
GO:0071541eukaryotic translation initiation factor 3 complex, eIF3m17
GO:2000060positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process29
GO:0005095GTPase inhibitor activity110
GO:0060326cell chemotaxis131
GO:0061518microglial cell proliferation11
GO:0031529ruffle organization210
GO:0033152immunoglobulin V(D)J recombination13
GO:0006898receptor-mediated endocytosis152
GO:0007010cytoskeleton organization461
GO:0034199activation of protein kinase A activity111
GO:0003678DNA helicase activity118
GO:0051209release of sequestered calcium ion into cytosol117
GO:0051525NFAT protein binding15
GO:0008652cellular amino acid biosynthetic process211
GO:0006543glutamine catabolic process23
GO:0030742GTP-dependent protein binding111
GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process237
GO:0030334regulation of cell migration236
GO:1902177positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway13
GO:0030165PDZ domain binding352
GO:0032623interleukin-2 production12
GO:0043495protein anchor15
GO:0045184establishment of protein localization115
GO:0055085transmembrane transport13329
GO:2001214positive regulation of vasculogenesis27
GO:0061029eyelid development in camera-type eye19
GO:0010034response to acetate11
GO:0031442positive regulation of mRNA 3'-end processing14
GO:0048286lung alveolus development127
GO:0033600negative regulation of mammary gland epithelial cell proliferation15
GO:0006290pyrimidine dimer repair24
GO:0016597amino acid binding114
GO:0051233spindle midzone18
GO:0001675acrosome assembly17
GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors18
GO:0043197dendritic spine151
GO:1901741positive regulation of myoblast fusion15
GO:0002906negative regulation of mature B cell apoptotic process14
GO:0017137Rab GTPase binding143
GO:0000186activation of MAPKK activity141
GO:0006353DNA-templated transcription, termination12
GO:0006813potassium ion transport139
GO:0001227RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription217
GO:0071300cellular response to retinoic acid132
GO:0007084mitotic nuclear envelope reassembly16
GO:0001673male germ cell nucleus110
GO:0045429positive regulation of nitric oxide biosynthetic process129
GO:0005212structural constituent of eye lens110
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator114
GO:0005770late endosome254
GO:0021510spinal cord development117
GO:0004508steroid 17-alpha-monooxygenase activity11
GO:0000389mRNA 3'-splice site recognition24
GO:0002521leukocyte differentiation11
GO:0005832chaperonin-containing T-complex47
GO:0008237metallopeptidase activity338
GO:0006120mitochondrial electron transport, NADH to ubiquinone225
GO:0005234extracellular-glutamate-gated ion channel activity111
GO:0060079regulation of excitatory postsynaptic membrane potential121
GO:0042391regulation of membrane potential136
GO:0021680cerebellar Purkinje cell layer development15
GO:0090141positive regulation of mitochondrial fission16
GO:0001655urogenital system development18
GO:0001104RNA polymerase II transcription cofactor activity424
GO:0006415translational termination263
GO:0001772immunological synapse223
GO:0006940regulation of smooth muscle contraction18
GO:0006469negative regulation of protein kinase activity250
GO:0034399nuclear periphery312
GO:0080182histone H3-K4 trimethylation16
GO:0030675Rac GTPase activator activity110
GO:0005938cell cortex677
GO:0030877beta-catenin destruction complex17
GO:0008344adult locomotory behavior133
GO:0000060protein import into nucleus, translocation119
GO:0045807positive regulation of endocytosis111
GO:0007172signal complex assembly17
GO:0030669clathrin-coated endocytic vesicle membrane123
GO:0017053transcriptional repressor complex242
GO:00515394 iron, 4 sulfur cluster binding421
GO:0016579protein deubiquitination129
GO:0031663lipopolysaccharide-mediated signaling pathway127
GO:0045766positive regulation of angiogenesis478
GO:0007599hemostasis14
GO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex12
GO:0050911detection of chemical stimulus involved in sensory perception of smell134
GO:0005605basal lamina110
GO:0051775response to redox state16
GO:0005884actin filament127
GO:0007281germ cell development122
GO:0008053mitochondrial fusion110
GO:0042770signal transduction in response to DNA damage111
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription119
GO:0071156regulation of cell cycle arrest24
GO:0004930G-protein coupled receptor activity2124
GO:0031175neuron projection development155
GO:0043296apical junction complex18
GO:0031618nuclear pericentric heterochromatin14
GO:0005876spindle microtubule424
GO:0061036positive regulation of cartilage development27
GO:0001821histamine secretion14
GO:0010224response to UV-B18
GO:0030532small nuclear ribonucleoprotein complex117
GO:0045732positive regulation of protein catabolic process134
GO:0005794Golgi apparatus6415
GO:0045746negative regulation of Notch signaling pathway110
GO:0060347heart trabecula formation113