reg-snw-339175

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.192 3.15e-07 4.90e-02 3.71e-02
chia-screen-data-Fav-reg-snw-339175 subnetwork

Genes (23)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Transcription factor Chia-Hits Primary Chia-Hits Secondary
NDUFA4L2 56901 44-2.4772.45921-Yes-
CIAO1 9391 1-1.2072.19242TF--
PHB 5245 82-2.7432.68936-YesYes
[ METTL2A ] 339175 1-1.0022.19221---
VARS 7407 60-2.3662.689124TFYes-
FBXO22 26263 36-1.7392.459208TF--
EPRS 2058 3-1.2862.286139TF--
EIF2S2 8894 40-2.9992.45922-YesYes
NCBP1 4686 41-2.5102.45944-YesYes
FBXL6 26233 28-2.2532.68922-Yes-
SYNCRIP 10492 42-2.4012.503144TFYesYes
EIF2S3 1968 3-1.9402.34513---
POLR2E 5434 30-2.0372.644201TFYes-
FTSJ1 24140 43-2.4632.68935-YesYes
PRPF4 9128 5-1.5202.342138TF--
ACTR5 79913 4-1.8872.36919---
CENPQ 55166 20-2.1372.45916-Yes-
CCT7 10574 40-2.3352.45938-Yes-
FUS 2521 11-1.9802.41453TF--
HNRNPU 3192 39-2.8692.64433-Yes-
GPS1 2873 86-3.6212.68936TFYesYes
POLH 5429 36-2.5862.45924-YesYes
PSPH 5723 14-2.0632.38711-Yes-

Interactions (33)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
FBXO22 26263 ACTR5 79913 pd > reg.ITFP.txt: no annot
PRPF4 9128 METTL2A 339175 pd > reg.ITFP.txt: no annot
CIAO1 9391 METTL2A 339175 pd > reg.ITFP.txt: no annot
VARS 7407 FBXO22 26263 pd <> reg.ITFP.txt: no annot
FUS 2521 POLR2E 5434 pd <> reg.ITFP.txt: no annot
VARS 7407 FTSJ1 24140 pd > reg.ITFP.txt: no annot
PHB 5245 VARS 7407 pd < reg.ITFP.txt: no annot
EPRS 2058 NCBP1 4686 pd > reg.ITFP.txt: no annot
POLR2E 5434 FTSJ1 24140 pd > reg.ITFP.txt: no annot
EPRS 2058 PRPF4 9128 pd <> reg.ITFP.txt: no annot
POLR2E 5434 VARS 7407 pd <> reg.ITFP.txt: no annot
EPRS 2058 SYNCRIP 10492 pd <> reg.ITFP.txt: no annot
FUS 2521 PRPF4 9128 pd <> reg.ITFP.txt: no annot
PHB 5245 FBXO22 26263 pd < reg.ITFP.txt: no annot
POLH 5429 FBXO22 26263 pd < reg.ITFP.txt: no annot
FBXO22 26263 CENPQ 55166 pd > reg.ITFP.txt: no annot
POLR2E 5434 PRPF4 9128 pd <> reg.ITFP.txt: no annot
NCBP1 4686 FBXO22 26263 pd < reg.ITFP.txt: no annot
EPRS 2058 HNRNPU 3192 pd > reg.ITFP.txt: no annot
FUS 2521 HNRNPU 3192 pd > reg.ITFP.txt: no annot
HNRNPU 3192 POLR2E 5434 pd < reg.ITFP.txt: no annot
VARS 7407 FBXL6 26233 pd > reg.ITFP.txt: no annot
VARS 7407 METTL2A 339175 pd > reg.ITFP.txt: no annot
EIF2S2 8894 FBXO22 26263 pd < reg.ITFP.txt: no annot
PSPH 5723 FBXO22 26263 pd < reg.ITFP.txt: no annot
FBXO22 26263 NDUFA4L2 56901 pd > reg.ITFP.txt: no annot
EIF2S3 1968 POLR2E 5434 pd < reg.ITFP.txt: no annot
GPS1 2873 PHB 5245 pd > reg.ITFP.txt: no annot
CCT7 10574 FBXO22 26263 pd < reg.ITFP.txt: no annot
EPRS 2058 METTL2A 339175 pd > reg.ITFP.txt: no annot
EIF2S3 1968 PRPF4 9128 pd < reg.ITFP.txt: no annot
EPRS 2058 CCT7 10574 pd > reg.ITFP.txt: no annot
FBXO22 26263 METTL2A 339175 pd > reg.ITFP.txt: no annot

Related GO terms (191)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000398mRNA splicing, via spliceosome3.79e-073.70e-034.315615128
GO:0008380RNA splicing1.69e-061.65e-023.948621165
GO:0010467gene expression1.70e-061.66e-022.836949535
GO:0097452GAIT complex3.18e-053.10e-017.730224
GO:0030529ribonucleoprotein complex3.62e-053.54e-014.3724582
GO:0070934CRD-mediated mRNA stabilization5.28e-055.16e-017.408225
GO:0070937CRD-mediated mRNA stability complex7.91e-057.73e-017.145226
GO:0005654nucleoplasm9.28e-059.06e-012.125968876
GO:0006396RNA processing1.07e-041.00e+004.9933440
GO:0003723RNA binding2.30e-041.00e+003.103522247
GO:0008135translation factor activity, nucleic acid binding5.47e-041.00e+005.8232415
GO:0001649osteoblast differentiation6.64e-041.00e+004.1053574
GO:0071346cellular response to interferon-gamma9.83e-041.00e+005.4082220
GO:00063707-methylguanosine mRNA capping1.42e-031.00e+005.1452524
GO:0006418tRNA aminoacylation for protein translation2.07e-031.00e+004.8722429
GO:0004832valine-tRNA ligase activity2.36e-031.00e+008.730111
GO:0002128tRNA nucleoside ribose methylation2.36e-031.00e+008.730111
GO:0008175tRNA methyltransferase activity2.36e-031.00e+008.730111
GO:0006438valyl-tRNA aminoacylation2.36e-031.00e+008.730111
GO:0017148negative regulation of translation2.68e-031.00e+004.6852533
GO:0050434positive regulation of viral transcription3.01e-031.00e+004.6012535
GO:0003743translation initiation factor activity3.36e-031.00e+004.5202837
GO:0048742regulation of skeletal muscle fiber development4.71e-031.00e+007.730112
GO:0097361CIA complex4.71e-031.00e+007.730112
GO:0006433prolyl-tRNA aminoacylation4.71e-031.00e+007.730112
GO:0004647phosphoserine phosphatase activity4.71e-031.00e+007.730112
GO:0016427tRNA (cytosine) methyltransferase activity4.71e-031.00e+007.730112
GO:0004818glutamate-tRNA ligase activity4.71e-031.00e+007.730112
GO:0004827proline-tRNA ligase activity4.71e-031.00e+007.730112
GO:0005846nuclear cap binding complex4.71e-031.00e+007.730112
GO:0002176male germ cell proliferation4.71e-031.00e+007.730112
GO:0006424glutamyl-tRNA aminoacylation4.71e-031.00e+007.730112
GO:0006368transcription elongation from RNA polymerase II promoter6.55e-031.00e+004.0292852
GO:0005850eukaryotic translation initiation factor 2 complex7.05e-031.00e+007.145123
GO:0071001U4/U6 snRNP7.05e-031.00e+007.145113
GO:0006563L-serine metabolic process7.05e-031.00e+007.145113
GO:0071013catalytic step 2 spliceosome8.93e-031.00e+003.7992561
GO:0045292mRNA cis splicing, via spliceosome9.39e-031.00e+006.730114
GO:0071817MMXD complex9.39e-031.00e+006.730124
GO:0031442positive regulation of mRNA 3'-end processing9.39e-031.00e+006.730114
GO:0006290pyrimidine dimer repair9.39e-031.00e+006.730124
GO:0006564L-serine biosynthetic process9.39e-031.00e+006.730114
GO:0035613RNA stem-loop binding9.39e-031.00e+006.730114
GO:0016226iron-sulfur cluster assembly1.17e-021.00e+006.408115
GO:0006282regulation of DNA repair1.17e-021.00e+006.408125
GO:2000323negative regulation of glucocorticoid receptor signaling pathway1.17e-021.00e+006.408115
GO:0002161aminoacyl-tRNA editing activity1.17e-021.00e+006.408115
GO:0071204histone pre-mRNA 3'end processing complex1.17e-021.00e+006.408115
GO:0050847progesterone receptor signaling pathway1.41e-021.00e+006.145126
GO:0002181cytoplasmic translation1.41e-021.00e+006.145116
GO:0001055RNA polymerase II activity1.41e-021.00e+006.145136
GO:0070914UV-damage excision repair1.41e-021.00e+006.145116
GO:0005829cytosol1.57e-021.00e+001.0969881787
GO:0002199zona pellucida receptor complex1.64e-021.00e+005.922147
GO:0000731DNA synthesis involved in DNA repair1.64e-021.00e+005.922117
GO:0006301postreplication repair1.64e-021.00e+005.922127
GO:0000339RNA cap binding1.64e-021.00e+005.922117
GO:0005832chaperonin-containing T-complex1.64e-021.00e+005.922147
GO:0005845mRNA cap binding complex1.87e-021.00e+005.730118
GO:0006450regulation of translational fidelity1.87e-021.00e+005.730118
GO:0010944negative regulation of transcription by competitive promoter binding1.87e-021.00e+005.730118
GO:0031011Ino80 complex1.87e-021.00e+005.730138
GO:0010388cullin deneddylation1.87e-021.00e+005.730148
GO:0010225response to UV-C2.10e-021.00e+005.560129
GO:0030488tRNA methylation2.10e-021.00e+005.560129
GO:0006379mRNA cleavage2.10e-021.00e+005.560129
GO:0071354cellular response to interleukin-62.10e-021.00e+005.560119
GO:2000060positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process2.10e-021.00e+005.560129
GO:0006413translational initiation2.24e-021.00e+003.1002699
GO:0005736DNA-directed RNA polymerase I complex2.33e-021.00e+005.4081410
GO:0005095GTPase inhibitor activity2.33e-021.00e+005.4081110
GO:0008143poly(A) binding2.33e-021.00e+005.4081210
GO:0001054RNA polymerase I activity2.33e-021.00e+005.4081410
GO:0060766negative regulation of androgen receptor signaling pathway2.56e-021.00e+005.2701411
GO:0008652cellular amino acid biosynthetic process2.56e-021.00e+005.2701211
GO:0008334histone mRNA metabolic process2.56e-021.00e+005.2701111
GO:0005666DNA-directed RNA polymerase III complex3.02e-021.00e+005.0291313
GO:0005665DNA-directed RNA polymerase II, core complex3.02e-021.00e+005.0291313
GO:0001056RNA polymerase III activity3.02e-021.00e+005.0291313
GO:0006386termination of RNA polymerase III transcription3.25e-021.00e+004.9221314
GO:0006385transcription elongation from RNA polymerase III promoter3.25e-021.00e+004.9221314
GO:0016575histone deacetylation3.25e-021.00e+004.9221214
GO:0000188inactivation of MAPK activity3.48e-021.00e+004.8231115
GO:0007339binding of sperm to zona pellucida3.48e-021.00e+004.8231415
GO:0044822poly(A) RNA binding3.53e-021.00e+001.410545799
GO:0003887DNA-directed DNA polymerase activity3.71e-021.00e+004.7301216
GO:0031667response to nutrient levels3.93e-021.00e+004.6421217
GO:0003899DNA-directed RNA polymerase activity4.16e-021.00e+004.5601318
GO:0031047gene silencing by RNA4.16e-021.00e+004.5601218
GO:0000375RNA splicing, via transesterification reactions4.16e-021.00e+004.5601118
GO:0033574response to testosterone4.16e-021.00e+004.5601118
GO:0036464cytoplasmic ribonucleoprotein granule4.39e-021.00e+004.4821119
GO:0006913nucleocytoplasmic transport4.61e-021.00e+004.4081220
GO:0034080CENP-A containing nucleosome assembly4.61e-021.00e+004.4081220
GO:0071897DNA biosynthetic process4.61e-021.00e+004.4081220
GO:0034660ncRNA metabolic process4.61e-021.00e+004.4081120
GO:0044267cellular protein metabolic process4.82e-021.00e+001.855314352
GO:0051084'de novo' posttranslational protein folding5.06e-021.00e+004.2701422
GO:0000387spliceosomal snRNP assembly5.06e-021.00e+004.2701122
GO:0008180COP9 signalosome5.51e-021.00e+004.1451624
GO:0005515protein binding5.56e-021.00e+000.527141984124
GO:0009267cellular response to starvation5.95e-021.00e+004.0291126
GO:0006360transcription from RNA polymerase I promoter6.18e-021.00e+003.9751427
GO:0000166nucleotide binding6.38e-021.00e+002.270213176
GO:0005737cytoplasm6.49e-021.00e+000.689101272633
GO:0006412translation6.51e-021.00e+002.254212178
GO:0005739mitochondrion6.54e-021.00e+001.366432659
GO:0004842ubiquitin-protein transferase activity6.57e-021.00e+002.246217179
GO:0006383transcription from RNA polymerase III promoter6.62e-021.00e+003.8721629
GO:0006446regulation of translational initiation6.62e-021.00e+003.8721229
GO:0045111intermediate filament cytoskeleton7.06e-021.00e+003.7761331
GO:0015030Cajal body7.28e-021.00e+003.7301332
GO:0007254JNK cascade7.72e-021.00e+003.6421134
GO:0016032viral process7.74e-021.00e+001.573330428
GO:0031124mRNA 3'-end processing7.94e-021.00e+003.6011435
GO:0044297cell body7.94e-021.00e+003.6011535
GO:0006281DNA repair8.18e-021.00e+002.065224203
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process8.59e-021.00e+003.4821438
GO:0006369termination of RNA polymerase II transcription8.59e-021.00e+003.4821538
GO:0006283transcription-coupled nucleotide-excision repair9.02e-021.00e+003.4081640
GO:0000775chromosome, centromeric region9.23e-021.00e+003.3721641
GO:0003684damaged DNA binding9.23e-021.00e+003.3721141
GO:0006406mRNA export from nucleus9.88e-021.00e+003.2701744
GO:0009612response to mechanical stimulus1.03e-011.00e+003.2061246
GO:0005634nucleus1.05e-011.00e+000.525111583246
GO:0032481positive regulation of type I interferon production1.07e-011.00e+003.1451348
GO:0007059chromosome segregation1.11e-011.00e+003.0861450
GO:0006310DNA recombination1.11e-011.00e+003.0861850
GO:0006334nucleosome assembly1.14e-011.00e+003.0571451
GO:0006302double-strand break repair1.16e-011.00e+003.0291552
GO:0006289nucleotide-excision repair1.18e-011.00e+003.0021653
GO:0005681spliceosomal complex1.22e-011.00e+002.9481855
GO:0016311dephosphorylation1.22e-011.00e+002.9481355
GO:0008584male gonad development1.26e-011.00e+002.8971157
GO:0042826histone deacetylase binding1.28e-011.00e+002.8721558
GO:0006464cellular protein modification process1.34e-011.00e+002.7991461
GO:0030018Z disc1.41e-011.00e+002.7301364
GO:0005524ATP binding1.53e-011.00e+000.929437892
GO:0030308negative regulation of cell growth1.53e-011.00e+002.6011370
GO:0051082unfolded protein binding1.53e-011.00e+002.6011570
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.80e-011.00e+002.3381584
GO:0006366transcription from RNA polymerase II promoter1.91e-011.00e+001.316223341
GO:0006461protein complex assembly1.94e-011.00e+002.2221291
GO:0000209protein polyubiquitination1.96e-011.00e+002.2061692
GO:0006511ubiquitin-dependent protein catabolic process1.96e-011.00e+002.2061692
GO:0006260DNA replication2.00e-011.00e+002.1751994
GO:0042802identical protein binding2.02e-011.00e+001.262215354
GO:0006457protein folding2.05e-011.00e+002.1301597
GO:0034641cellular nitrogen compound metabolic process2.20e-011.00e+002.01615105
GO:0042981regulation of apoptotic process2.33e-011.00e+001.92214112
GO:0043005neuron projection2.35e-011.00e+001.91016113
GO:0000287magnesium ion binding2.39e-011.00e+001.88414115
GO:0007049cell cycle2.39e-011.00e+001.88418115
GO:0003924GTPase activity2.46e-011.00e+001.83517119
GO:0016607nuclear speck2.51e-011.00e+001.79918122
GO:0006184GTP catabolic process2.66e-011.00e+001.70717130
GO:0044212transcription regulatory region DNA binding2.88e-011.00e+001.570113143
GO:0001701in utero embryonic development3.07e-011.00e+001.46317154
GO:0016020membrane3.15e-011.00e+000.4934561207
GO:0006367transcription initiation from RNA polymerase II promoter3.18e-011.00e+001.399118161
GO:0005730nucleolus3.20e-011.00e+000.4814741217
GO:0005874microtubule3.21e-011.00e+001.381110163
GO:0016071mRNA metabolic process3.33e-011.00e+001.320110170
GO:0016567protein ubiquitination3.61e-011.00e+001.175114188
GO:0016070RNA metabolic process3.61e-011.00e+001.175110188
GO:0005743mitochondrial inner membrane3.75e-011.00e+001.10819197
GO:0005525GTP binding3.75e-011.00e+001.108112197
GO:0006357regulation of transcription from RNA polymerase II promoter3.84e-011.00e+001.065114203
GO:0003677DNA binding3.89e-011.00e+000.428352947
GO:0019899enzyme binding3.94e-011.00e+001.01617210
GO:0006508proteolysis4.68e-011.00e+000.685111264
GO:0008285negative regulation of cell proliferation4.85e-011.00e+000.616111277
GO:0008284positive regulation of cell proliferation4.87e-011.00e+000.60618279
GO:0009986cell surface5.02e-011.00e+000.54515291
GO:0006355regulation of transcription, DNA-templated5.10e-011.00e+000.248231715
GO:0000278mitotic cell cycle5.29e-011.00e+000.435128314
GO:0045892negative regulation of transcription, DNA-templated5.32e-011.00e+000.422117317
GO:0005509calcium ion binding5.70e-011.00e+000.27519351
GO:0045893positive regulation of transcription, DNA-templated5.96e-011.00e+000.171121377
GO:0005783endoplasmic reticulum6.00e-011.00e+000.156112381
GO:0044281small molecule metabolic process6.03e-011.00e+000.009235844
GO:0042803protein homodimerization activity6.44e-011.00e+00-0.012113428
GO:0046872metal ion binding6.60e-011.00e+00-0.137224934
GO:0045087innate immune response6.64e-011.00e+00-0.090112452
GO:0000122negative regulation of transcription from RNA polymerase II promoter6.68e-011.00e+00-0.103129456
GO:0005887integral component of plasma membrane7.53e-011.00e+00-0.43818575
GO:0070062extracellular vesicular exosome7.68e-011.00e+00-0.3663511641
GO:0007165signal transduction7.78e-011.00e+00-0.542124618
GO:0008270zinc ion binding8.32e-011.00e+00-0.776139727
GO:0006351transcription, DNA-templated9.32e-011.00e+00-1.3421471076
GO:0005886plasma membrane9.90e-011.00e+00-2.0711461784