reg-snw-191

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.287	1.02e-07	2.69e-02	2.11e-02

chia-screen-data-Fav-reg-snw-191 subnetwork

Genes (20)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Transcription factor	Chia-Hits Primary	Chia-Hits Secondary
NDUFA4L2	56901	44	-2.477	2.459	21	-	Yes	-
KARS	3735	12	-1.759	2.428	123	TF	-	-
CENPA	1058	27	-2.185	2.393	205	TF	Yes	-
PHB2	11331	17	-2.236	2.449	11	-	Yes	-
RAE1	8480	7	-1.501	2.342	204	TF	-	-
PHB	5245	82	-2.743	2.689	36	-	Yes	Yes
REXO4	57109	5	-1.743	2.287	95	TF	-	-
VARS	7407	60	-2.366	2.689	124	TF	Yes	-
FBXO22	26263	36	-1.739	2.459	208	TF	-	-
FBXL6	26233	28	-2.253	2.689	22	-	Yes	-
NCBP1	4686	41	-2.510	2.459	44	-	Yes	Yes
EIF2S2	8894	40	-2.999	2.459	22	-	Yes	Yes
FTSJ1	24140	43	-2.463	2.689	35	-	Yes	Yes
[ AHCY ]	191	1	-1.236	2.287	41	-	-	-
GSPT1	2935	32	-2.313	2.503	17	-	Yes	Yes
CCT7	10574	40	-2.335	2.459	38	-	Yes	-
CPSF3	51692	43	-2.686	2.503	31	-	Yes	Yes
GPS1	2873	86	-3.621	2.689	36	TF	Yes	Yes
NOLC1	9221	15	-1.985	2.503	113	TF	-	-
POLH	5429	36	-2.586	2.459	24	-	Yes	Yes

Interactions (33)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
RAE1	8480	REXO4	57109	pd	<>	reg.ITFP.txt: no annot
VARS	7407	FBXO22	26263	pd	<>	reg.ITFP.txt: no annot
CENPA	1058	FBXL6	26233	pd	>	reg.ITFP.txt: no annot
AHCY	191	KARS	3735	pd	<	reg.ITFP.txt: no annot
NOLC1	9221	FTSJ1	24140	pd	>	reg.ITFP.txt: no annot
VARS	7407	FTSJ1	24140	pd	>	reg.ITFP.txt: no annot
PHB	5245	VARS	7407	pd	<	reg.ITFP.txt: no annot
AHCY	191	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
RAE1	8480	NOLC1	9221	pd	<>	reg.ITFP.txt: no annot
PHB	5245	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
POLH	5429	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
AHCY	191	NOLC1	9221	pd	<	reg.ITFP.txt: no annot
AHCY	191	RAE1	8480	pd	<	reg.ITFP.txt: no annot
KARS	3735	NOLC1	9221	pd	<>	reg.ITFP.txt: no annot
CENPA	1058	KARS	3735	pd	<>	reg.ITFP.txt: no annot
KARS	3735	PHB2	11331	pd	>	reg.ITFP.txt: no annot
NCBP1	4686	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
GSPT1	2935	NOLC1	9221	pd	<	reg.ITFP.txt: no annot
CCT7	10574	REXO4	57109	pd	<	reg.ITFP.txt: no annot
AHCY	191	REXO4	57109	pd	<	reg.ITFP.txt: no annot
CENPA	1058	RAE1	8480	pd	<>	reg.ITFP.txt: no annot
VARS	7407	FBXL6	26233	pd	>	reg.ITFP.txt: no annot
AHCY	191	VARS	7407	pd	<	reg.ITFP.txt: no annot
KARS	3735	PHB	5245	pd	>	reg.ITFP.txt: no annot
EIF2S2	8894	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
FBXO22	26263	NDUFA4L2	56901	pd	>	reg.ITFP.txt: no annot
RAE1	8480	CPSF3	51692	pd	>	reg.ITFP.txt: no annot
GSPT1	2935	KARS	3735	pd	<	reg.ITFP.txt: no annot
GPS1	2873	PHB	5245	pd	>	reg.ITFP.txt: no annot
CCT7	10574	FBXO22	26263	pd	<	reg.ITFP.txt: no annot
RAE1	8480	FBXL6	26233	pd	>	reg.ITFP.txt: no annot
CENPA	1058	NDUFA4L2	56901	pd	>	reg.ITFP.txt: no annot
GPS1	2873	PHB2	11331	pd	>	reg.ITFP.txt: no annot

Related GO terms (189)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006406	mRNA export from nucleus	9.22e-05	9.01e-01	5.057	3	7	44
GO:0006379	mRNA cleavage	1.42e-04	1.00e+00	6.762	2	2	9
GO:0003723	RNA binding	1.41e-03	1.00e+00	2.983	4	22	247
GO:0006418	tRNA aminoacylation for protein translation	1.57e-03	1.00e+00	5.073	2	4	29
GO:0005739	mitochondrion	1.58e-03	1.00e+00	2.152	6	32	659
GO:0004832	valine-tRNA ligase activity	2.05e-03	1.00e+00	8.931	1	1	1
GO:0006430	lysyl-tRNA aminoacylation	2.05e-03	1.00e+00	8.931	1	1	1
GO:0002128	tRNA nucleoside ribose methylation	2.05e-03	1.00e+00	8.931	1	1	1
GO:0004824	lysine-tRNA ligase activity	2.05e-03	1.00e+00	8.931	1	1	1
GO:0004013	adenosylhomocysteinase activity	2.05e-03	1.00e+00	8.931	1	1	1
GO:0008175	tRNA methyltransferase activity	2.05e-03	1.00e+00	8.931	1	1	1
GO:0000939	condensed chromosome inner kinetochore	2.05e-03	1.00e+00	8.931	1	1	1
GO:0006438	valyl-tRNA aminoacylation	2.05e-03	1.00e+00	8.931	1	1	1
GO:0031124	mRNA 3'-end processing	2.28e-03	1.00e+00	4.802	2	4	35
GO:0006369	termination of RNA polymerase II transcription	2.68e-03	1.00e+00	4.684	2	5	38
GO:0010467	gene expression	3.78e-03	1.00e+00	2.190	5	49	535
GO:0048742	regulation of skeletal muscle fiber development	4.09e-03	1.00e+00	7.931	1	1	2
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	4.09e-03	1.00e+00	7.931	1	1	2
GO:0003747	translation release factor activity	4.09e-03	1.00e+00	7.931	1	2	2
GO:0005846	nuclear cap binding complex	4.09e-03	1.00e+00	7.931	1	1	2
GO:0015966	diadenosine tetraphosphate biosynthetic process	4.09e-03	1.00e+00	7.931	1	1	2
GO:0002176	male germ cell proliferation	4.09e-03	1.00e+00	7.931	1	1	2
GO:0005850	eukaryotic translation initiation factor 2 complex	6.13e-03	1.00e+00	7.347	1	2	3
GO:0000778	condensed nuclear chromosome kinetochore	6.13e-03	1.00e+00	7.347	1	2	3
GO:0071459	protein localization to chromosome, centromeric region	6.13e-03	1.00e+00	7.347	1	1	3
GO:0045292	mRNA cis splicing, via spliceosome	8.17e-03	1.00e+00	6.931	1	1	4
GO:0031442	positive regulation of mRNA 3'-end processing	8.17e-03	1.00e+00	6.931	1	1	4
GO:0006290	pyrimidine dimer repair	8.17e-03	1.00e+00	6.931	1	2	4
GO:0007000	nucleolus organization	8.17e-03	1.00e+00	6.931	1	1	4
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	8.17e-03	1.00e+00	6.931	1	1	4
GO:0016032	viral process	1.01e-02	1.00e+00	2.190	4	30	428
GO:0004521	endoribonuclease activity	1.02e-02	1.00e+00	6.610	1	1	5
GO:0006398	histone mRNA 3'-end processing	1.02e-02	1.00e+00	6.610	1	1	5
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	1.02e-02	1.00e+00	6.610	1	1	5
GO:0006282	regulation of DNA repair	1.02e-02	1.00e+00	6.610	1	2	5
GO:0060744	mammary gland branching involved in thelarche	1.02e-02	1.00e+00	6.610	1	1	5
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	1.02e-02	1.00e+00	6.610	1	1	5
GO:0002161	aminoacyl-tRNA editing activity	1.02e-02	1.00e+00	6.610	1	1	5
GO:0030529	ribonucleoprotein complex	1.20e-02	1.00e+00	3.574	2	5	82
GO:0050847	progesterone receptor signaling pathway	1.22e-02	1.00e+00	6.347	1	2	6
GO:0002181	cytoplasmic translation	1.22e-02	1.00e+00	6.347	1	1	6
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1.26e-02	1.00e+00	3.539	2	5	84
GO:0002199	zona pellucida receptor complex	1.43e-02	1.00e+00	6.124	1	4	7
GO:0000731	DNA synthesis involved in DNA repair	1.43e-02	1.00e+00	6.124	1	1	7
GO:0006301	postreplication repair	1.43e-02	1.00e+00	6.124	1	2	7
GO:0008409	5'-3' exonuclease activity	1.43e-02	1.00e+00	6.124	1	2	7
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	1.43e-02	1.00e+00	6.124	1	2	7
GO:0000339	RNA cap binding	1.43e-02	1.00e+00	6.124	1	1	7
GO:0000780	condensed nuclear chromosome, centromeric region	1.43e-02	1.00e+00	6.124	1	1	7
GO:0005832	chaperonin-containing T-complex	1.43e-02	1.00e+00	6.124	1	4	7
GO:0051382	kinetochore assembly	1.43e-02	1.00e+00	6.124	1	2	7
GO:0005845	mRNA cap binding complex	1.63e-02	1.00e+00	5.931	1	1	8
GO:0006450	regulation of translational fidelity	1.63e-02	1.00e+00	5.931	1	1	8
GO:0010944	negative regulation of transcription by competitive promoter binding	1.63e-02	1.00e+00	5.931	1	1	8
GO:0010388	cullin deneddylation	1.63e-02	1.00e+00	5.931	1	4	8
GO:0010225	response to UV-C	1.83e-02	1.00e+00	5.762	1	2	9
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	1.83e-02	1.00e+00	5.762	1	2	9
GO:0071354	cellular response to interleukin-6	1.83e-02	1.00e+00	5.762	1	1	9
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	1.83e-02	1.00e+00	5.762	1	3	9
GO:0044822	poly(A) RNA binding	1.99e-02	1.00e+00	1.611	5	45	799
GO:0005095	GTPase inhibitor activity	2.03e-02	1.00e+00	5.610	1	1	10
GO:0060766	negative regulation of androgen receptor signaling pathway	2.23e-02	1.00e+00	5.472	1	4	11
GO:0006479	protein methylation	2.23e-02	1.00e+00	5.472	1	2	11
GO:0008334	histone mRNA metabolic process	2.23e-02	1.00e+00	5.472	1	1	11
GO:0007049	cell cycle	2.27e-02	1.00e+00	3.086	2	8	115
GO:0000132	establishment of mitotic spindle orientation	2.43e-02	1.00e+00	5.347	1	2	12
GO:0004527	exonuclease activity	2.43e-02	1.00e+00	5.347	1	4	12
GO:0060749	mammary gland alveolus development	2.63e-02	1.00e+00	5.231	1	1	13
GO:0000398	mRNA splicing, via spliceosome	2.78e-02	1.00e+00	2.931	2	15	128
GO:0016597	amino acid binding	2.83e-02	1.00e+00	5.124	1	1	14
GO:0000096	sulfur amino acid metabolic process	2.83e-02	1.00e+00	5.124	1	1	14
GO:0016575	histone deacetylation	2.83e-02	1.00e+00	5.124	1	2	14
GO:0005654	nucleoplasm	2.85e-02	1.00e+00	1.479	5	68	876
GO:0008135	translation factor activity, nucleic acid binding	3.03e-02	1.00e+00	5.025	1	4	15
GO:0000188	inactivation of MAPK activity	3.03e-02	1.00e+00	5.025	1	1	15
GO:0007339	binding of sperm to zona pellucida	3.03e-02	1.00e+00	5.025	1	4	15
GO:0003887	DNA-directed DNA polymerase activity	3.23e-02	1.00e+00	4.931	1	2	16
GO:0005640	nuclear outer membrane	3.43e-02	1.00e+00	4.844	1	1	17
GO:0006730	one-carbon metabolic process	3.43e-02	1.00e+00	4.844	1	1	17
GO:0031047	gene silencing by RNA	3.63e-02	1.00e+00	4.762	1	2	18
GO:0006378	mRNA polyadenylation	3.63e-02	1.00e+00	4.762	1	3	18
GO:0006913	nucleocytoplasmic transport	4.02e-02	1.00e+00	4.610	1	2	20
GO:0034080	CENP-A containing nucleosome assembly	4.02e-02	1.00e+00	4.610	1	2	20
GO:0071897	DNA biosynthetic process	4.02e-02	1.00e+00	4.610	1	2	20
GO:0034660	ncRNA metabolic process	4.02e-02	1.00e+00	4.610	1	1	20
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	4.22e-02	1.00e+00	4.539	1	2	21
GO:0030331	estrogen receptor binding	4.41e-02	1.00e+00	4.472	1	2	22
GO:0051084	'de novo' posttranslational protein folding	4.41e-02	1.00e+00	4.472	1	4	22
GO:0000387	spliceosomal snRNP assembly	4.41e-02	1.00e+00	4.472	1	1	22
GO:0008380	RNA splicing	4.42e-02	1.00e+00	2.565	2	21	165
GO:0000049	tRNA binding	4.61e-02	1.00e+00	4.408	1	2	23
GO:0006370	7-methylguanosine mRNA capping	4.81e-02	1.00e+00	4.347	1	5	24
GO:0008180	COP9 signalosome	4.81e-02	1.00e+00	4.347	1	6	24
GO:0008033	tRNA processing	5.00e-02	1.00e+00	4.288	1	2	25
GO:0010827	regulation of glucose transport	5.00e-02	1.00e+00	4.288	1	7	25
GO:0004842	ubiquitin-protein transferase activity	5.12e-02	1.00e+00	2.448	2	17	179
GO:0009267	cellular response to starvation	5.20e-02	1.00e+00	4.231	1	1	26
GO:0005829	cytosol	5.78e-02	1.00e+00	0.936	7	88	1787
GO:0006446	regulation of translational initiation	5.78e-02	1.00e+00	4.073	1	2	29
GO:0005743	mitochondrial inner membrane	6.07e-02	1.00e+00	2.309	2	9	197
GO:0005525	GTP binding	6.07e-02	1.00e+00	2.309	2	12	197
GO:0090305	nucleic acid phosphodiester bond hydrolysis	6.17e-02	1.00e+00	3.977	1	6	31
GO:0005737	cytoplasm	6.33e-02	1.00e+00	0.739	9	127	2633
GO:0007077	mitotic nuclear envelope disassembly	6.36e-02	1.00e+00	3.931	1	9	32
GO:0015030	Cajal body	6.36e-02	1.00e+00	3.931	1	3	32
GO:0000786	nucleosome	6.74e-02	1.00e+00	3.844	1	2	34
GO:0071407	cellular response to organic cyclic compound	6.74e-02	1.00e+00	3.844	1	2	34
GO:0007254	JNK cascade	6.74e-02	1.00e+00	3.844	1	1	34
GO:0050434	positive regulation of viral transcription	6.94e-02	1.00e+00	3.802	1	5	35
GO:0032259	methylation	6.94e-02	1.00e+00	3.802	1	1	35
GO:0044297	cell body	6.94e-02	1.00e+00	3.802	1	5	35
GO:0008645	hexose transport	7.13e-02	1.00e+00	3.762	1	8	36
GO:0003743	translation initiation factor activity	7.32e-02	1.00e+00	3.722	1	8	37
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	7.51e-02	1.00e+00	3.684	1	4	38
GO:0000775	chromosome, centromeric region	8.08e-02	1.00e+00	3.574	1	6	41
GO:0003684	damaged DNA binding	8.08e-02	1.00e+00	3.574	1	1	41
GO:0005515	protein binding	8.40e-02	1.00e+00	0.507	12	198	4124
GO:0015758	glucose transport	9.39e-02	1.00e+00	3.347	1	8	48
GO:0006334	nucleosome assembly	9.95e-02	1.00e+00	3.259	1	4	51
GO:0005643	nuclear pore	9.95e-02	1.00e+00	3.259	1	12	51
GO:0006368	transcription elongation from RNA polymerase II promoter	1.01e-01	1.00e+00	3.231	1	8	52
GO:0005524	ATP binding	1.03e-01	1.00e+00	1.131	4	37	892
GO:0008584	male gonad development	1.11e-01	1.00e+00	3.099	1	1	57
GO:0042826	histone deacetylase binding	1.12e-01	1.00e+00	3.073	1	5	58
GO:0006464	cellular protein modification process	1.18e-01	1.00e+00	3.001	1	4	61
GO:0046872	metal ion binding	1.18e-01	1.00e+00	1.064	4	24	934
GO:0006415	translational termination	1.22e-01	1.00e+00	2.954	1	2	63
GO:0042470	melanosome	1.23e-01	1.00e+00	2.931	1	3	64
GO:0030018	Z disc	1.23e-01	1.00e+00	2.931	1	3	64
GO:0006364	rRNA processing	1.29e-01	1.00e+00	2.865	1	2	67
GO:0000278	mitotic cell cycle	1.34e-01	1.00e+00	1.637	2	28	314
GO:0030308	negative regulation of cell growth	1.34e-01	1.00e+00	2.802	1	3	70
GO:0051082	unfolded protein binding	1.34e-01	1.00e+00	2.802	1	5	70
GO:0045892	negative regulation of transcription, DNA-templated	1.36e-01	1.00e+00	1.623	2	17	317
GO:0016363	nuclear matrix	1.39e-01	1.00e+00	2.742	1	10	73
GO:0001649	osteoblast differentiation	1.41e-01	1.00e+00	2.722	1	5	74
GO:0015630	microtubule cytoskeleton	1.43e-01	1.00e+00	2.703	1	5	75
GO:0006366	transcription from RNA polymerase II promoter	1.53e-01	1.00e+00	1.518	2	23	341
GO:0005635	nuclear envelope	1.57e-01	1.00e+00	2.556	1	6	83
GO:0044267	cellular protein metabolic process	1.61e-01	1.00e+00	1.472	2	14	352
GO:0000209	protein polyubiquitination	1.73e-01	1.00e+00	2.408	1	6	92
GO:0006511	ubiquitin-dependent protein catabolic process	1.73e-01	1.00e+00	2.408	1	6	92
GO:0006260	DNA replication	1.76e-01	1.00e+00	2.377	1	9	94
GO:0006805	xenobiotic metabolic process	1.76e-01	1.00e+00	2.377	1	3	94
GO:0008017	microtubule binding	1.81e-01	1.00e+00	2.332	1	9	97
GO:0006457	protein folding	1.81e-01	1.00e+00	2.332	1	5	97
GO:0006413	translational initiation	1.85e-01	1.00e+00	2.302	1	6	99
GO:0005634	nucleus	1.88e-01	1.00e+00	0.437	9	158	3246
GO:0034641	cellular nitrogen compound metabolic process	1.95e-01	1.00e+00	2.217	1	5	105
GO:0042981	regulation of apoptotic process	2.06e-01	1.00e+00	2.124	1	4	112
GO:0003924	GTPase activity	2.18e-01	1.00e+00	2.037	1	7	119
GO:0000082	G1/S transition of mitotic cell cycle	2.27e-01	1.00e+00	1.966	1	4	125
GO:0005730	nucleolus	2.33e-01	1.00e+00	0.682	4	74	1217
GO:0006184	GTP catabolic process	2.35e-01	1.00e+00	1.909	1	7	130
GO:0005759	mitochondrial matrix	2.50e-01	1.00e+00	1.813	1	7	139
GO:0044212	transcription regulatory region DNA binding	2.56e-01	1.00e+00	1.772	1	13	143
GO:0005622	intracellular	2.59e-01	1.00e+00	1.752	1	2	145
GO:0001701	in utero embryonic development	2.73e-01	1.00e+00	1.665	1	7	154
GO:0005874	microtubule	2.86e-01	1.00e+00	1.583	1	10	163
GO:0007067	mitotic nuclear division	2.89e-01	1.00e+00	1.565	1	9	165
GO:0016071	mRNA metabolic process	2.96e-01	1.00e+00	1.522	1	10	170
GO:0019221	cytokine-mediated signaling pathway	2.99e-01	1.00e+00	1.505	1	10	172
GO:0006412	translation	3.08e-01	1.00e+00	1.456	1	12	178
GO:0005975	carbohydrate metabolic process	3.20e-01	1.00e+00	1.392	1	10	186
GO:0016567	protein ubiquitination	3.22e-01	1.00e+00	1.377	1	14	188
GO:0016070	RNA metabolic process	3.22e-01	1.00e+00	1.377	1	10	188
GO:0005856	cytoskeleton	3.25e-01	1.00e+00	1.362	1	8	190
GO:0006281	DNA repair	3.43e-01	1.00e+00	1.266	1	24	203
GO:0043234	protein complex	3.53e-01	1.00e+00	1.217	1	13	210
GO:0019899	enzyme binding	3.53e-01	1.00e+00	1.217	1	7	210
GO:0003682	chromatin binding	4.08e-01	1.00e+00	0.954	1	15	252
GO:0006508	proteolysis	4.22e-01	1.00e+00	0.887	1	11	264
GO:0046982	protein heterodimerization activity	4.24e-01	1.00e+00	0.882	1	11	265
GO:0006355	regulation of transcription, DNA-templated	4.36e-01	1.00e+00	0.450	2	31	715
GO:0008285	negative regulation of cell proliferation	4.38e-01	1.00e+00	0.818	1	11	277
GO:0070062	extracellular vesicular exosome	4.40e-01	1.00e+00	0.251	4	51	1641
GO:0055085	transmembrane transport	4.96e-01	1.00e+00	0.570	1	13	329
GO:0042802	identical protein binding	5.23e-01	1.00e+00	0.464	1	15	354
GO:0044281	small molecule metabolic process	5.26e-01	1.00e+00	0.210	2	35	844
GO:0045893	positive regulation of transcription, DNA-templated	5.45e-01	1.00e+00	0.373	1	21	377
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	6.16e-01	1.00e+00	0.099	1	29	456
GO:0005887	integral component of plasma membrane	7.03e-01	1.00e+00	-0.236	1	8	575
GO:0003700	sequence-specific DNA binding transcription factor activity	7.08e-01	1.00e+00	-0.253	1	22	582
GO:0007165	signal transduction	7.30e-01	1.00e+00	-0.340	1	24	618
GO:0005576	extracellular region	7.55e-01	1.00e+00	-0.441	1	15	663
GO:0003677	DNA binding	8.70e-01	1.00e+00	-0.956	1	52	947
GO:0005886	plasma membrane	9.03e-01	1.00e+00	-0.869	2	46	1784
GO:0006351	transcription, DNA-templated	9.03e-01	1.00e+00	-1.140	1	47	1076
GO:0016020	membrane	9.29e-01	1.00e+00	-1.306	1	56	1207

chia-Fav

reg-snw-191

Statistics

Genes (20)

Interactions (33)

Related GO terms (189)