reg-snw-10576

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.377 3.29e-08 1.43e-02 1.19e-02
chia-screen-data-Fav-reg-snw-10576 subnetwork

Genes (20)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Transcription factor Chia-Hits Primary Chia-Hits Secondary
[ CCT2 ] 10576 1-1.5092.37794---
FOXM1 2305 9-1.6692.412210TF--
PHB 5245 82-2.7432.68936-YesYes
VARS 7407 60-2.3662.689124TFYes-
GTF2A2 2958 9-1.9382.37741TF--
FBXO22 26263 36-1.7392.459208TF--
APLP2 334 15-2.7322.3894-YesYes
NCBP1 4686 41-2.5102.45944-YesYes
EIF2S2 8894 40-2.9992.45922-YesYes
SYNCRIP 10492 42-2.4012.503144TFYesYes
TRAIP 10293 13-2.5462.45430TFYes-
XPNPEP1 7511 8-1.7792.38676TF--
ETF1 2107 35-2.8292.5036-YesYes
FUS 2521 11-1.9802.41453TF--
CPSF3 51692 43-2.6862.50331-YesYes
HNRNPU 3192 39-2.8692.64433-Yes-
GPS1 2873 86-3.6212.68936TFYesYes
NOLC1 9221 15-1.9852.503113TF--
POLH 5429 36-2.5862.45924-YesYes
SFPQ 6421 15-2.0512.389142TFYes-

Interactions (22)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
FOXM1 2305 CCT2 10576 pd > reg.ITFP.txt: no annot
NCBP1 4686 FBXO22 26263 pd < reg.ITFP.txt: no annot
APLP2 334 SFPQ 6421 pd < reg.ITFP.txt: no annot
SYNCRIP 10492 CPSF3 51692 pd > reg.ITFP.txt: no annot
SFPQ 6421 CCT2 10576 pd > reg.ITFP.txt: no annot
FUS 2521 HNRNPU 3192 pd > reg.ITFP.txt: no annot
SYNCRIP 10492 CCT2 10576 pd > reg.ITFP.txt: no annot
CCT2 10576 FBXO22 26263 pd < reg.ITFP.txt: no annot
TRAIP 10293 CPSF3 51692 pd > reg.ITFP.txt: no annot
VARS 7407 CCT2 10576 pd > reg.ITFP.txt: no annot
PHB 5245 FBXO22 26263 pd < reg.ITFP.txt: no annot
ETF1 2107 SYNCRIP 10492 pd < reg.ITFP.txt: no annot
FOXM1 2305 TRAIP 10293 pd <> reg.ITFP.txt: no annot
PHB 5245 VARS 7407 pd < reg.ITFP.txt: no annot
POLH 5429 FBXO22 26263 pd < reg.ITFP.txt: no annot
FUS 2521 CCT2 10576 pd > reg.ITFP.txt: no annot
VARS 7407 FBXO22 26263 pd <> reg.ITFP.txt: no annot
EIF2S2 8894 FBXO22 26263 pd < reg.ITFP.txt: no annot
GTF2A2 2958 CCT2 10576 pd > reg.ITFP.txt: no annot
XPNPEP1 7511 CCT2 10576 pd > reg.ITFP.txt: no annot
NOLC1 9221 CCT2 10576 pd > reg.ITFP.txt: no annot
GPS1 2873 PHB 5245 pd > reg.ITFP.txt: no annot

Related GO terms (216)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0003723RNA binding3.56e-073.48e-033.790722247
GO:0008380RNA splicing6.77e-076.61e-034.150621165
GO:0005654nucleoplasm2.57e-062.51e-022.4791068876
GO:0000398mRNA splicing, via spliceosome4.74e-064.63e-024.253515128
GO:0010467gene expression5.40e-065.27e-022.868849535
GO:0030529ribonucleoprotein complex2.02e-051.97e-014.5744582
GO:0070934CRD-mediated mRNA stabilization3.97e-053.88e-017.610225
GO:0070937CRD-mediated mRNA stability complex5.95e-055.81e-017.347226
GO:0044822poly(A) RNA binding1.00e-049.80e-012.289845799
GO:0005515protein binding1.06e-041.00e+001.009171984124
GO:0006379mRNA cleavage1.42e-041.00e+006.762229
GO:0001649osteoblast differentiation4.34e-041.00e+004.3073574
GO:0007049cell cycle1.57e-031.00e+003.67138115
GO:0004832valine-tRNA ligase activity2.05e-031.00e+008.931111
GO:0016149translation release factor activity, codon specific2.05e-031.00e+008.931111
GO:0008079translation termination factor activity2.05e-031.00e+008.931111
GO:0006438valyl-tRNA aminoacylation2.05e-031.00e+008.931111
GO:0031124mRNA 3'-end processing2.28e-031.00e+004.8022435
GO:0006369termination of RNA polymerase II transcription2.68e-031.00e+004.6842538
GO:0044212transcription regulatory region DNA binding2.92e-031.00e+003.357313143
GO:0006396RNA processing2.97e-031.00e+004.6102440
GO:0006406mRNA export from nucleus3.58e-031.00e+004.4722744
GO:0048742regulation of skeletal muscle fiber development4.09e-031.00e+007.931112
GO:0003747translation release factor activity4.09e-031.00e+007.931122
GO:0005846nuclear cap binding complex4.09e-031.00e+007.931112
GO:0002176male germ cell proliferation4.09e-031.00e+007.931112
GO:0051123RNA polymerase II transcriptional preinitiation complex assembly4.09e-031.00e+007.931112
GO:2000781positive regulation of double-strand break repair4.09e-031.00e+007.931112
GO:0006366transcription from RNA polymerase II promoter4.54e-031.00e+002.518423341
GO:0006368transcription elongation from RNA polymerase II promoter4.97e-031.00e+004.2312852
GO:0000166nucleotide binding5.24e-031.00e+003.057313176
GO:0005850eukaryotic translation initiation factor 2 complex6.13e-031.00e+007.347123
GO:1902177positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway6.13e-031.00e+007.347113
GO:0046914transition metal ion binding6.13e-031.00e+007.347113
GO:0070006metalloaminopeptidase activity6.13e-031.00e+007.347113
GO:0042826histone deacetylase binding6.15e-031.00e+004.0732558
GO:0071013catalytic step 2 spliceosome6.78e-031.00e+004.0012561
GO:0006281DNA repair7.77e-031.00e+002.851324203
GO:0045292mRNA cis splicing, via spliceosome8.17e-031.00e+006.931114
GO:0097452GAIT complex8.17e-031.00e+006.931124
GO:0031442positive regulation of mRNA 3'-end processing8.17e-031.00e+006.931114
GO:0006290pyrimidine dimer repair8.17e-031.00e+006.931124
GO:0006449regulation of translational termination8.17e-031.00e+006.931114
GO:0007000nucleolus organization8.17e-031.00e+006.931114
GO:0071156regulation of cell cycle arrest8.17e-031.00e+006.931124
GO:0010815bradykinin catabolic process8.17e-031.00e+006.931114
GO:0007176regulation of epidermal growth factor-activated receptor activity8.17e-031.00e+006.931114
GO:0004521endoribonuclease activity1.02e-021.00e+006.610115
GO:0006398histone mRNA 3'-end processing1.02e-021.00e+006.610115
GO:0090344negative regulation of cell aging1.02e-021.00e+006.610115
GO:0005672transcription factor TFIIA complex1.02e-021.00e+006.610115
GO:0006282regulation of DNA repair1.02e-021.00e+006.610125
GO:0032873negative regulation of stress-activated MAPK cascade1.02e-021.00e+006.610115
GO:2000323negative regulation of glucocorticoid receptor signaling pathway1.02e-021.00e+006.610115
GO:0002161aminoacyl-tRNA editing activity1.02e-021.00e+006.610115
GO:0071204histone pre-mRNA 3'end processing complex1.02e-021.00e+006.610115
GO:0042382paraspeckles1.02e-021.00e+006.610135
GO:0050847progesterone receptor signaling pathway1.22e-021.00e+006.347126
GO:0042754negative regulation of circadian rhythm1.22e-021.00e+006.347126
GO:0046578regulation of Ras protein signal transduction1.22e-021.00e+006.347116
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.26e-021.00e+003.5392584
GO:0002199zona pellucida receptor complex1.43e-021.00e+006.124147
GO:0000731DNA synthesis involved in DNA repair1.43e-021.00e+006.124117
GO:0006301postreplication repair1.43e-021.00e+006.124127
GO:00084095'-3' exonuclease activity1.43e-021.00e+006.124127
GO:0007617mating behavior1.43e-021.00e+006.124117
GO:0000339RNA cap binding1.43e-021.00e+006.124117
GO:0005832chaperonin-containing T-complex1.43e-021.00e+006.124147
GO:0000380alternative mRNA splicing, via spliceosome1.43e-021.00e+006.124127
GO:0005845mRNA cap binding complex1.63e-021.00e+005.931118
GO:0006878cellular copper ion homeostasis1.63e-021.00e+005.931118
GO:0006450regulation of translational fidelity1.63e-021.00e+005.931118
GO:0010944negative regulation of transcription by competitive promoter binding1.63e-021.00e+005.931118
GO:0010388cullin deneddylation1.63e-021.00e+005.931148
GO:0010225response to UV-C1.83e-021.00e+005.762129
GO:2000060positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process1.83e-021.00e+005.762129
GO:0071354cellular response to interleukin-61.83e-021.00e+005.762119
GO:0005847mRNA cleavage and polyadenylation specificity factor complex1.83e-021.00e+005.762139
GO:0001967suckling behavior2.03e-021.00e+005.6101410
GO:0005095GTPase inhibitor activity2.03e-021.00e+005.6101110
GO:0008143poly(A) binding2.03e-021.00e+005.6101210
GO:0051131chaperone-mediated protein complex assembly2.03e-021.00e+005.6101310
GO:0060766negative regulation of androgen receptor signaling pathway2.23e-021.00e+005.4721411
GO:0006479protein methylation2.23e-021.00e+005.4721211
GO:0008334histone mRNA metabolic process2.23e-021.00e+005.4721111
GO:0017025TBP-class protein binding2.43e-021.00e+005.3471112
GO:0045892negative regulation of transcription, DNA-templated2.57e-021.00e+002.208317317
GO:2000377regulation of reactive oxygen species metabolic process2.63e-021.00e+005.2311113
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator2.83e-021.00e+005.1241114
GO:0043393regulation of protein binding2.83e-021.00e+005.1241214
GO:0016575histone deacetylation2.83e-021.00e+005.1241214
GO:0004177aminopeptidase activity2.83e-021.00e+005.1241314
GO:0008135translation factor activity, nucleic acid binding3.03e-021.00e+005.0251415
GO:0000188inactivation of MAPK activity3.03e-021.00e+005.0251115
GO:0007339binding of sperm to zona pellucida3.03e-021.00e+005.0251415
GO:0070932histone H3 deacetylation3.03e-021.00e+005.0251215
GO:0005730nucleolus3.06e-021.00e+001.2676741217
GO:0003887DNA-directed DNA polymerase activity3.23e-021.00e+004.9311216
GO:0044267cellular protein metabolic process3.36e-021.00e+002.057314352
GO:0043022ribosome binding3.43e-021.00e+004.8441217
GO:0031047gene silencing by RNA3.63e-021.00e+004.7621218
GO:0006378mRNA polyadenylation3.63e-021.00e+004.7621318
GO:0005634nucleus3.67e-021.00e+000.726111583246
GO:0036464cytoplasmic ribonucleoprotein granule3.82e-021.00e+004.6841119
GO:0006913nucleocytoplasmic transport4.02e-021.00e+004.6101220
GO:0071346cellular response to interferon-gamma4.02e-021.00e+004.6101220
GO:0071897DNA biosynthetic process4.02e-021.00e+004.6101220
GO:0034660ncRNA metabolic process4.02e-021.00e+004.6101120
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic4.22e-021.00e+004.5391221
GO:0051084'de novo' posttranslational protein folding4.41e-021.00e+004.4721422
GO:0000387spliceosomal snRNP assembly4.41e-021.00e+004.4721122
GO:0001103RNA polymerase II repressing transcription factor binding4.61e-021.00e+004.4081223
GO:0016071mRNA metabolic process4.66e-021.00e+002.522210170
GO:00063707-methylguanosine mRNA capping4.81e-021.00e+004.3471524
GO:0008180COP9 signalosome4.81e-021.00e+004.3471624
GO:0030901midbrain development5.00e-021.00e+004.2881125
GO:0000976transcription regulatory region sequence-specific DNA binding5.00e-021.00e+004.2881325
GO:0006412translation5.06e-021.00e+002.456212178
GO:0004842ubiquitin-protein transferase activity5.12e-021.00e+002.448217179
GO:0030145manganese ion binding5.20e-021.00e+004.2311326
GO:0009267cellular response to starvation5.20e-021.00e+004.2311126
GO:0005057receptor signaling protein activity5.20e-021.00e+004.2311226
GO:0016032viral process5.48e-021.00e+001.775330428
GO:0016070RNA metabolic process5.58e-021.00e+002.377210188
GO:0050885neuromuscular process controlling balance5.59e-021.00e+004.1241128
GO:0006418tRNA aminoacylation for protein translation5.78e-021.00e+004.0731429
GO:0042752regulation of circadian rhythm5.78e-021.00e+004.0731529
GO:0006446regulation of translational initiation5.78e-021.00e+004.0731229
GO:0005737cytoplasm6.33e-021.00e+000.73991272633
GO:0015030Cajal body6.36e-021.00e+003.9311332
GO:0000122negative regulation of transcription from RNA polymerase II promoter6.39e-021.00e+001.684329456
GO:0017148negative regulation of translation6.55e-021.00e+003.8871533
GO:0007254JNK cascade6.74e-021.00e+003.8441134
GO:0050434positive regulation of viral transcription6.94e-021.00e+003.8021535
GO:0044297cell body6.94e-021.00e+003.8021535
GO:0030900forebrain development7.13e-021.00e+003.7621236
GO:0003743translation initiation factor activity7.32e-021.00e+003.7221837
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process7.51e-021.00e+003.6841438
GO:0048511rhythmic process7.51e-021.00e+003.6841538
GO:0003684damaged DNA binding8.08e-021.00e+003.5741141
GO:0004867serine-type endopeptidase inhibitor activity8.27e-021.00e+003.5391142
GO:0001047core promoter binding8.27e-021.00e+003.5391442
GO:0001570vasculogenesis8.83e-021.00e+003.4401245
GO:0008203cholesterol metabolic process9.21e-021.00e+003.3771247
GO:0007626locomotory behavior9.21e-021.00e+003.3771147
GO:0001558regulation of cell growth9.58e-021.00e+003.3171249
GO:0006310DNA recombination9.77e-021.00e+003.2881850
GO:0005524ATP binding1.03e-011.00e+001.131437892
GO:0008584male gonad development1.11e-011.00e+003.0991157
GO:0000785chromatin1.14e-011.00e+003.0491659
GO:0006464cellular protein modification process1.18e-011.00e+003.0011461
GO:0003677DNA binding1.22e-011.00e+001.044452947
GO:0006415translational termination1.22e-011.00e+002.9541263
GO:0030018Z disc1.23e-011.00e+002.9311364
GO:0006364rRNA processing1.29e-011.00e+002.8651267
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity1.29e-011.00e+002.8651567
GO:0030308negative regulation of cell growth1.34e-011.00e+002.8021370
GO:0051082unfolded protein binding1.34e-011.00e+002.8021570
GO:0010951negative regulation of endopeptidase activity1.36e-011.00e+002.7821271
GO:0001889liver development1.36e-011.00e+002.7821471
GO:0016363nuclear matrix1.39e-011.00e+002.74211073
GO:0051726regulation of cell cycle1.39e-011.00e+002.7421373
GO:0005829cytosol1.44e-011.00e+000.7136881787
GO:0005739mitochondrion1.49e-011.00e+001.152332659
GO:0042127regulation of cell proliferation1.52e-011.00e+002.6101480
GO:0042802identical protein binding1.63e-011.00e+001.464215354
GO:0008201heparin binding1.71e-011.00e+002.4241491
GO:0000209protein polyubiquitination1.73e-011.00e+002.4081692
GO:0006511ubiquitin-dependent protein catabolic process1.73e-011.00e+002.4081692
GO:0006260DNA replication1.76e-011.00e+002.3771994
GO:0045893positive regulation of transcription, DNA-templated1.79e-011.00e+001.373221377
GO:0000086G2/M transition of mitotic cell cycle1.81e-011.00e+002.3321797
GO:0006457protein folding1.81e-011.00e+002.3321597
GO:0006413translational initiation1.85e-011.00e+002.3021699
GO:0006397mRNA processing2.03e-011.00e+002.150112110
GO:0042981regulation of apoptotic process2.06e-011.00e+002.12414112
GO:0042803protein homodimerization activity2.18e-011.00e+001.190213428
GO:0016020membrane2.28e-011.00e+000.6944561207
GO:0016874ligase activity2.60e-011.00e+001.742111146
GO:0001701in utero embryonic development2.73e-011.00e+001.66517154
GO:0006367transcription initiation from RNA polymerase II promoter2.83e-011.00e+001.601118161
GO:0005874microtubule2.86e-011.00e+001.583110163
GO:0007067mitotic nuclear division2.89e-011.00e+001.56519165
GO:0046872metal ion binding2.98e-011.00e+000.649324934
GO:0003713transcription coactivator activity3.17e-011.00e+001.408121184
GO:0016567protein ubiquitination3.22e-011.00e+001.377114188
GO:0005743mitochondrial inner membrane3.35e-011.00e+001.30919197
GO:0005525GTP binding3.35e-011.00e+001.309112197
GO:0035556intracellular signal transduction3.38e-011.00e+001.29515199
GO:0008134transcription factor binding3.52e-011.00e+001.224110209
GO:0019899enzyme binding3.53e-011.00e+001.21717210
GO:0030054cell junction3.64e-011.00e+001.16315218
GO:0007165signal transduction3.64e-011.00e+000.660224618
GO:0030198extracellular matrix organization3.68e-011.00e+001.14417221
GO:0007186G-protein coupled receptor signaling pathway3.78e-011.00e+001.09214229
GO:0019901protein kinase binding3.82e-011.00e+001.07318232
GO:0045944positive regulation of transcription from RNA polymerase II promoter3.84e-011.00e+000.601229644
GO:0008283cell proliferation3.91e-011.00e+001.03118239
GO:0006508proteolysis4.22e-011.00e+000.887111264
GO:0046982protein heterodimerization activity4.24e-011.00e+000.882111265
GO:0043565sequence-specific DNA binding4.36e-011.00e+000.82818275
GO:0006355regulation of transcription, DNA-templated4.36e-011.00e+000.450231715
GO:0008285negative regulation of cell proliferation4.38e-011.00e+000.818111277
GO:0070062extracellular vesicular exosome4.40e-011.00e+000.2514511641
GO:0008284positive regulation of cell proliferation4.40e-011.00e+000.80718279
GO:0008270zinc ion binding4.45e-011.00e+000.426239727
GO:0009986cell surface4.54e-011.00e+000.74715291
GO:0000278mitotic cell cycle4.80e-011.00e+000.637128314
GO:0048471perinuclear region of cytoplasm5.12e-011.00e+000.505111344
GO:0005783endoplasmic reticulum5.49e-011.00e+000.358112381
GO:0006915apoptotic process5.77e-011.00e+000.248115411
GO:0006351transcription, DNA-templated6.64e-011.00e+00-0.1402471076
GO:0005887integral component of plasma membrane7.03e-011.00e+00-0.23618575
GO:0003700sequence-specific DNA binding transcription factor activity7.08e-011.00e+00-0.253122582
GO:0005886plasma membrane9.03e-011.00e+00-0.8692461784
GO:0016021integral component of membrane9.67e-011.00e+00-1.6441191526