reg-snw-25996

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.217 2.37e-07 4.23e-02 3.22e-02
chia-screen-data-Fav-reg-snw-25996 subnetwork

Genes (21)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Transcription factor Chia-Hits Primary Chia-Hits Secondary
NDUFA4L2 56901 44-2.4772.45921-Yes-
CENPA 1058 27-2.1852.393205TFYes-
FOXM1 2305 9-1.6692.412210TF--
PHB 5245 82-2.7432.68936-YesYes
[ REXO2 ] 25996 1-0.6012.2174TF--
BCL6B 255877 3-2.7232.3409TFYesYes
VARS 7407 60-2.3662.689124TFYes-
FBXO22 26263 36-1.7392.459208TF--
MYH11 4629 1-1.6522.21723---
NCBP1 4686 41-2.5102.45944-YesYes
EIF2S2 8894 40-2.9992.45922-YesYes
SHFM1 7979 7-2.3662.3893-Yes-
TRAIP 10293 13-2.5462.45430TFYes-
VWF 7450 4-2.3812.34058TFYesYes
CENPQ 55166 20-2.1372.45916-Yes-
CCT7 10574 40-2.3352.45938-Yes-
CD34 947 1-2.1002.2172-Yes-
VASH2 79805 1-0.7512.21716---
GPS1 2873 86-3.6212.68936TFYesYes
POLH 5429 36-2.5862.45924-YesYes
PSPH 5723 14-2.0632.38711-Yes-

Interactions (23)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
VARS 7407 FBXO22 26263 pd <> reg.ITFP.txt: no annot
PHB 5245 VARS 7407 pd < reg.ITFP.txt: no annot
FOXM1 2305 SHFM1 7979 pd > reg.ITFP.txt: no annot
CENPA 1058 FOXM1 2305 pd <> reg.ITFP.txt: no annot
PHB 5245 FBXO22 26263 pd < reg.ITFP.txt: no annot
POLH 5429 FBXO22 26263 pd < reg.ITFP.txt: no annot
FOXM1 2305 MYH11 4629 pd > reg.ITFP.txt: no annot
FBXO22 26263 CENPQ 55166 pd > reg.ITFP.txt: no annot
POLH 5429 REXO2 25996 pd < reg.ITFP.txt: no annot
MYH11 4629 REXO2 25996 pd < reg.ITFP.txt: no annot
CD34 947 VWF 7450 pd < reg.ITFP.txt: no annot
NCBP1 4686 FBXO22 26263 pd < reg.ITFP.txt: no annot
REXO2 25996 VASH2 79805 pd > reg.ITFP.txt: no annot
FOXM1 2305 TRAIP 10293 pd <> reg.ITFP.txt: no annot
EIF2S2 8894 FBXO22 26263 pd < reg.ITFP.txt: no annot
PSPH 5723 FBXO22 26263 pd < reg.ITFP.txt: no annot
FBXO22 26263 NDUFA4L2 56901 pd > reg.ITFP.txt: no annot
FOXM1 2305 NDUFA4L2 56901 pd > reg.ITFP.txt: no annot
GPS1 2873 PHB 5245 pd > reg.ITFP.txt: no annot
CCT7 10574 FBXO22 26263 pd < reg.ITFP.txt: no annot
VWF 7450 BCL6B 255877 pd <> reg.ITFP.txt: no annot
MYH11 4629 VWF 7450 pd < reg.ITFP.txt: no annot
CENPA 1058 NDUFA4L2 56901 pd > reg.ITFP.txt: no annot

Related GO terms (262)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0034080CENP-A containing nucleosome assembly8.18e-041.00e+005.5392220
GO:0036053glomerular endothelium fenestra2.15e-031.00e+008.861111
GO:0035759mesangial cell-matrix adhesion2.15e-031.00e+008.861111
GO:0004832valine-tRNA ligase activity2.15e-031.00e+008.861111
GO:0071971extracellular vesicular exosome assembly2.15e-031.00e+008.861111
GO:0043199sulfate binding2.15e-031.00e+008.861111
GO:0000939condensed chromosome inner kinetochore2.15e-031.00e+008.861111
GO:1900038negative regulation of cellular response to hypoxia2.15e-031.00e+008.861111
GO:0006438valyl-tRNA aminoacylation2.15e-031.00e+008.861111
GO:1900035negative regulation of cellular response to heat2.15e-031.00e+008.861111
GO:1900168positive regulation of glial cell line-derived neurotrophic factor secretion2.15e-031.00e+008.861111
GO:0072254metanephric glomerular mesangial cell differentiation2.15e-031.00e+008.861111
GO:0000775chromosome, centromeric region3.43e-031.00e+004.5042641
GO:1900041negative regulation of interleukin-2 secretion4.30e-031.00e+007.861112
GO:0005846nuclear cap binding complex4.30e-031.00e+007.861112
GO:0002176male germ cell proliferation4.30e-031.00e+007.861112
GO:2000781positive regulation of double-strand break repair4.30e-031.00e+007.861112
GO:0019865immunoglobulin binding4.30e-031.00e+007.861112
GO:0048742regulation of skeletal muscle fiber development4.30e-031.00e+007.861112
GO:0071657positive regulation of granulocyte colony-stimulating factor production4.30e-031.00e+007.861112
GO:0004647phosphoserine phosphatase activity4.30e-031.00e+007.861112
GO:0030241skeletal muscle myosin thick filament assembly4.30e-031.00e+007.861112
GO:0038001paracrine signaling4.30e-031.00e+007.861112
GO:0006334nucleosome assembly5.27e-031.00e+004.1892451
GO:0072011glomerular endothelium development6.44e-031.00e+007.276113
GO:0000778condensed nuclear chromosome kinetochore6.44e-031.00e+007.276123
GO:0061042vascular wound healing6.44e-031.00e+007.276113
GO:0006563L-serine metabolic process6.44e-031.00e+007.276113
GO:0071459protein localization to chromosome, centromeric region6.44e-031.00e+007.276113
GO:0071636positive regulation of transforming growth factor beta production6.44e-031.00e+007.276113
GO:0005850eukaryotic translation initiation factor 2 complex6.44e-031.00e+007.276123
GO:0030485smooth muscle contractile fiber6.44e-031.00e+007.276113
GO:0048251elastic fiber assembly8.58e-031.00e+006.861114
GO:0033093Weibel-Palade body8.58e-031.00e+006.861114
GO:0005654nucleoplasm8.58e-031.00e+001.671668876
GO:0045292mRNA cis splicing, via spliceosome8.58e-031.00e+006.861114
GO:0031442positive regulation of mRNA 3'-end processing8.58e-031.00e+006.861114
GO:0006290pyrimidine dimer repair8.58e-031.00e+006.861124
GO:0006564L-serine biosynthetic process8.58e-031.00e+006.861114
GO:0007599hemostasis8.58e-031.00e+006.861114
GO:0071156regulation of cell cycle arrest8.58e-031.00e+006.861124
GO:0001889liver development1.00e-021.00e+003.7112471
GO:0072089stem cell proliferation1.07e-021.00e+006.539115
GO:0042482positive regulation of odontogenesis1.07e-021.00e+006.539115
GO:0032873negative regulation of stress-activated MAPK cascade1.07e-021.00e+006.539115
GO:0060290transdifferentiation1.07e-021.00e+006.539115
GO:2000323negative regulation of glucocorticoid receptor signaling pathway1.07e-021.00e+006.539115
GO:0002161aminoacyl-tRNA editing activity1.07e-021.00e+006.539115
GO:0005859muscle myosin complex1.07e-021.00e+006.539115
GO:0090344negative regulation of cell aging1.07e-021.00e+006.539115
GO:0003158endothelium development1.07e-021.00e+006.539115
GO:0009117nucleotide metabolic process1.07e-021.00e+006.539115
GO:0006282regulation of DNA repair1.07e-021.00e+006.539125
GO:0005739mitochondrion1.13e-021.00e+001.819532659
GO:0045766positive regulation of angiogenesis1.20e-021.00e+003.5762478
GO:0050847progesterone receptor signaling pathway1.28e-021.00e+006.276126
GO:0048739cardiac muscle fiber development1.28e-021.00e+006.276116
GO:0032982myosin filament1.28e-021.00e+006.276116
GO:0046578regulation of Ras protein signal transduction1.28e-021.00e+006.276116
GO:0002199zona pellucida receptor complex1.50e-021.00e+006.054147
GO:0000339RNA cap binding1.50e-021.00e+006.054117
GO:0051382kinetochore assembly1.50e-021.00e+006.054127
GO:0000731DNA synthesis involved in DNA repair1.50e-021.00e+006.054117
GO:0006301postreplication repair1.50e-021.00e+006.054127
GO:2001214positive regulation of vasculogenesis1.50e-021.00e+006.054127
GO:0000780condensed nuclear chromosome, centromeric region1.50e-021.00e+006.054117
GO:0005832chaperonin-containing T-complex1.50e-021.00e+006.054147
GO:0005845mRNA cap binding complex1.71e-021.00e+005.861118
GO:0006450regulation of translational fidelity1.71e-021.00e+005.861118
GO:0030195negative regulation of blood coagulation1.71e-021.00e+005.861118
GO:0071425hematopoietic stem cell proliferation1.71e-021.00e+005.861118
GO:0010388cullin deneddylation1.71e-021.00e+005.861148
GO:0003094glomerular filtration1.71e-021.00e+005.861118
GO:0031091platelet alpha granule1.71e-021.00e+005.861118
GO:0010944negative regulation of transcription by competitive promoter binding1.71e-021.00e+005.861118
GO:0006379mRNA cleavage1.92e-021.00e+005.691129
GO:0071354cellular response to interleukin-61.92e-021.00e+005.691119
GO:0045019negative regulation of nitric oxide biosynthetic process1.92e-021.00e+005.691119
GO:0010225response to UV-C1.92e-021.00e+005.691129
GO:2000060positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process1.92e-021.00e+005.691129
GO:0032039integrator complex1.92e-021.00e+005.691119
GO:0006939smooth muscle contraction2.13e-021.00e+005.5391110
GO:0005095GTPase inhibitor activity2.13e-021.00e+005.5391110
GO:0008334histone mRNA metabolic process2.34e-021.00e+005.4021111
GO:0001935endothelial cell proliferation2.34e-021.00e+005.4021111
GO:0060766negative regulation of androgen receptor signaling pathway2.34e-021.00e+005.4021411
GO:0008652cellular amino acid biosynthetic process2.34e-021.00e+005.4021211
GO:00084083'-5' exonuclease activity2.34e-021.00e+005.4021111
GO:0007049cell cycle2.50e-021.00e+003.01628115
GO:0000132establishment of mitotic spindle orientation2.55e-021.00e+005.2761212
GO:0001894tissue homeostasis2.55e-021.00e+005.2761112
GO:0005829cytosol2.64e-021.00e+001.0588881787
GO:0007597blood coagulation, intrinsic pathway2.76e-021.00e+005.1611213
GO:2000377regulation of reactive oxygen species metabolic process2.76e-021.00e+005.1611113
GO:0032733positive regulation of interleukin-10 production2.76e-021.00e+005.1611213
GO:0031589cell-substrate adhesion2.76e-021.00e+005.1611113
GO:0000278mitotic cell cycle2.85e-021.00e+002.151328314
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator2.97e-021.00e+005.0541114
GO:0016575histone deacetylation2.97e-021.00e+005.0541214
GO:0009897external side of plasma membrane3.18e-021.00e+002.82823131
GO:0048870cell motility3.18e-021.00e+004.9541115
GO:0008135translation factor activity, nucleic acid binding3.18e-021.00e+004.9541415
GO:0000188inactivation of MAPK activity3.18e-021.00e+004.9541115
GO:0007339binding of sperm to zona pellucida3.18e-021.00e+004.9541415
GO:0003887DNA-directed DNA polymerase activity3.39e-021.00e+004.8611216
GO:0031667response to nutrient levels3.60e-021.00e+004.7741217
GO:0044212transcription regulatory region DNA binding3.73e-021.00e+002.701213143
GO:0031047gene silencing by RNA3.80e-021.00e+004.6911218
GO:0033574response to testosterone3.80e-021.00e+004.6911118
GO:0006913nucleocytoplasmic transport4.22e-021.00e+004.5391220
GO:1901215negative regulation of neuron death4.22e-021.00e+004.5391120
GO:0032720negative regulation of tumor necrosis factor production4.22e-021.00e+004.5391120
GO:0034660ncRNA metabolic process4.22e-021.00e+004.5391120
GO:0071897DNA biosynthetic process4.22e-021.00e+004.5391220
GO:0006139nucleobase-containing compound metabolic process4.63e-021.00e+004.4021222
GO:0051084'de novo' posttranslational protein folding4.63e-021.00e+004.4021422
GO:0008307structural constituent of muscle4.63e-021.00e+004.4021222
GO:0000387spliceosomal snRNP assembly4.63e-021.00e+004.4021122
GO:0045171intercellular bridge4.84e-021.00e+004.3381123
GO:0009925basal plasma membrane4.84e-021.00e+004.3381123
GO:00063707-methylguanosine mRNA capping5.04e-021.00e+004.2761524
GO:0008180COP9 signalosome5.04e-021.00e+004.2761624
GO:0009267cellular response to starvation5.45e-021.00e+004.1611126
GO:0005057receptor signaling protein activity5.45e-021.00e+004.1611226
GO:0001890placenta development5.45e-021.00e+004.1611226
GO:0004842ubiquitin-protein transferase activity5.59e-021.00e+002.377217179
GO:0006418tRNA aminoacylation for protein translation6.06e-021.00e+004.0031429
GO:0003774motor activity6.06e-021.00e+004.0031129
GO:0006446regulation of translational initiation6.06e-021.00e+004.0031229
GO:0090305nucleic acid phosphodiester bond hydrolysis6.47e-021.00e+003.9071631
GO:0045111intermediate filament cytoskeleton6.47e-021.00e+003.9071331
GO:0006281DNA repair6.97e-021.00e+002.196224203
GO:0000786nucleosome7.07e-021.00e+003.7741234
GO:0007254JNK cascade7.07e-021.00e+003.7741134
GO:0000122negative regulation of transcription from RNA polymerase II promoter7.21e-021.00e+001.613329456
GO:0031093platelet alpha granule lumen7.27e-021.00e+003.7321335
GO:0031124mRNA 3'-end processing7.27e-021.00e+003.7321435
GO:0044297cell body7.27e-021.00e+003.7321535
GO:0050434positive regulation of viral transcription7.27e-021.00e+003.7321535
GO:0003743translation initiation factor activity7.67e-021.00e+003.6521837
GO:0001948glycoprotein binding7.67e-021.00e+003.6521137
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process7.87e-021.00e+003.6131438
GO:0006369termination of RNA polymerase II transcription7.87e-021.00e+003.6131538
GO:0009611response to wounding8.46e-021.00e+003.5041241
GO:0003684damaged DNA binding8.46e-021.00e+003.5041141
GO:0005737cytoplasm8.51e-021.00e+000.66991272633
GO:0008217regulation of blood pressure8.66e-021.00e+003.4691242
GO:0000724double-strand break repair via homologous recombination8.66e-021.00e+003.4691542
GO:0001938positive regulation of endothelial cell proliferation8.86e-021.00e+003.4351143
GO:0006406mRNA export from nucleus9.06e-021.00e+003.4021744
GO:0008283cell proliferation9.24e-021.00e+001.96028239
GO:0051087chaperone binding9.25e-021.00e+003.3691345
GO:0001570vasculogenesis9.25e-021.00e+003.3691245
GO:0009612response to mechanical stimulus9.45e-021.00e+003.3381246
GO:0001725stress fiber9.45e-021.00e+003.3381646
GO:0005518collagen binding9.64e-021.00e+003.3061247
GO:0000502proteasome complex9.64e-021.00e+003.3061347
GO:0003723RNA binding9.77e-021.00e+001.913222247
GO:0030097hemopoiesis9.84e-021.00e+003.2761348
GO:0005758mitochondrial intermembrane space9.84e-021.00e+003.2761448
GO:0001558regulation of cell growth1.00e-011.00e+003.2461249
GO:0002020protease binding1.02e-011.00e+003.2171350
GO:0010467gene expression1.05e-011.00e+001.383349535
GO:0006368transcription elongation from RNA polymerase II promoter1.06e-011.00e+003.1611852
GO:0006936muscle contraction1.10e-011.00e+003.1061554
GO:0005730nucleolus1.11e-011.00e+000.9345741217
GO:0050776regulation of immune response1.12e-011.00e+003.0801255
GO:0016311dephosphorylation1.12e-011.00e+003.0801355
GO:0008584male gonad development1.16e-011.00e+003.0281157
GO:0042826histone deacetylase binding1.18e-011.00e+003.0031558
GO:0006464cellular protein modification process1.23e-011.00e+002.9301461
GO:0005515protein binding1.23e-011.00e+000.436121984124
GO:0002576platelet degranulation1.25e-011.00e+002.9071362
GO:0016337single organismal cell-cell adhesion1.25e-011.00e+002.9071362
GO:0010629negative regulation of gene expression1.25e-011.00e+002.9071162
GO:0051015actin filament binding1.27e-011.00e+002.8841263
GO:0030018Z disc1.29e-011.00e+002.8611364
GO:0042470melanosome1.29e-011.00e+002.8611364
GO:0047485protein N-terminus binding1.31e-011.00e+002.8391665
GO:0003676nucleic acid binding1.33e-011.00e+002.8171466
GO:0005178integrin binding1.37e-011.00e+002.7741368
GO:0051082unfolded protein binding1.40e-011.00e+002.7321570
GO:0030308negative regulation of cell growth1.40e-011.00e+002.7321370
GO:0007165signal transduction1.44e-011.00e+001.175324618
GO:0051726regulation of cell cycle1.46e-011.00e+002.6711373
GO:0045892negative regulation of transcription, DNA-templated1.47e-011.00e+001.553217317
GO:0001649osteoblast differentiation1.48e-011.00e+002.6521574
GO:0030246carbohydrate binding1.59e-011.00e+002.5391180
GO:0042127regulation of cell proliferation1.59e-011.00e+002.5391480
GO:0030529ribonucleoprotein complex1.62e-011.00e+002.5041582
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.66e-011.00e+002.4691584
GO:0006366transcription from RNA polymerase II promoter1.66e-011.00e+001.447223341
GO:0048471perinuclear region of cytoplasm1.68e-011.00e+001.435211344
GO:0051260protein homooligomerization1.71e-011.00e+002.4181287
GO:0044267cellular protein metabolic process1.74e-011.00e+001.402214352
GO:0042802identical protein binding1.76e-011.00e+001.393215354
GO:0050900leukocyte migration1.79e-011.00e+002.3531291
GO:0000209protein polyubiquitination1.80e-011.00e+002.3381692
GO:0006511ubiquitin-dependent protein catabolic process1.80e-011.00e+002.3381692
GO:0006260DNA replication1.84e-011.00e+002.3061994
GO:0000086G2/M transition of mitotic cell cycle1.89e-011.00e+002.2611797
GO:0006457protein folding1.89e-011.00e+002.2611597
GO:0006413translational initiation1.93e-011.00e+002.2321699
GO:0005516calmodulin binding1.93e-011.00e+002.2321499
GO:0045893positive regulation of transcription, DNA-templated1.94e-011.00e+001.303221377
GO:0005764lysosome1.95e-011.00e+002.21712100
GO:0034641cellular nitrogen compound metabolic process2.03e-011.00e+002.14715105
GO:0010628positive regulation of gene expression2.05e-011.00e+002.13312106
GO:0031012extracellular matrix2.07e-011.00e+002.12014107
GO:0042981regulation of apoptotic process2.15e-011.00e+002.05414112
GO:0043005neuron projection2.17e-011.00e+002.04116113
GO:0000287magnesium ion binding2.20e-011.00e+002.01614115
GO:0005578proteinaceous extracellular matrix2.20e-011.00e+002.01614115
GO:0042803protein homodimerization activity2.34e-011.00e+001.120213428
GO:0016032viral process2.34e-011.00e+001.120230428
GO:0005634nucleus2.37e-011.00e+000.36791583246
GO:0000398mRNA splicing, via spliceosome2.42e-011.00e+001.861115128
GO:0005759mitochondrial matrix2.60e-011.00e+001.74217139
GO:0030168platelet activation2.63e-011.00e+001.72215141
GO:0016874ligase activity2.71e-011.00e+001.671111146
GO:0016324apical plasma membrane2.73e-011.00e+001.66112147
GO:0001701in utero embryonic development2.84e-011.00e+001.59417154
GO:0005874microtubule2.98e-011.00e+001.512110163
GO:0005524ATP binding3.00e-011.00e+000.645337892
GO:0008380RNA splicing3.01e-011.00e+001.495121165
GO:0016071mRNA metabolic process3.09e-011.00e+001.452110170
GO:0006412translation3.21e-011.00e+001.385112178
GO:0046872metal ion binding3.26e-011.00e+000.579324934
GO:0008152metabolic process3.27e-011.00e+001.35316182
GO:0003677DNA binding3.33e-011.00e+000.559352947
GO:0016567protein ubiquitination3.35e-011.00e+001.306114188
GO:0016070RNA metabolic process3.35e-011.00e+001.306110188
GO:0005743mitochondrial inner membrane3.48e-011.00e+001.23919197
GO:0035556intracellular signal transduction3.51e-011.00e+001.22415199
GO:0005887integral component of plasma membrane3.53e-011.00e+000.69428575
GO:0008134transcription factor binding3.65e-011.00e+001.154110209
GO:0019899enzyme binding3.67e-011.00e+001.14717210
GO:0030198extracellular matrix organization3.82e-011.00e+001.07317221
GO:0019901protein kinase binding3.97e-011.00e+001.00318232
GO:0007411axon guidance4.03e-011.00e+000.97218237
GO:0007155cell adhesion4.13e-011.00e+000.93018244
GO:0003682chromatin binding4.23e-011.00e+000.884115252
GO:0046982protein heterodimerization activity4.39e-011.00e+000.811111265
GO:0043565sequence-specific DNA binding4.51e-011.00e+000.75818275
GO:0008285negative regulation of cell proliferation4.54e-011.00e+000.747111277
GO:0008284positive regulation of cell proliferation4.56e-011.00e+000.73718279
GO:0005925focal adhesion4.60e-011.00e+000.722114282
GO:0006355regulation of transcription, DNA-templated4.62e-011.00e+000.379231715
GO:0070062extracellular vesicular exosome4.80e-011.00e+000.1814511641
GO:0044822poly(A) RNA binding5.22e-011.00e+000.219245799
GO:0007596blood coagulation5.24e-011.00e+000.456113339
GO:0005509calcium ion binding5.37e-011.00e+000.40619351
GO:0005783endoplasmic reticulum5.67e-011.00e+000.287112381
GO:0006915apoptotic process5.95e-011.00e+000.178115411
GO:0003700sequence-specific DNA binding transcription factor activity7.25e-011.00e+00-0.324122582
GO:0045944positive regulation of transcription from RNA polymerase II promoter7.62e-011.00e+00-0.470129644
GO:0005576extracellular region7.72e-011.00e+00-0.512115663
GO:0008270zinc ion binding8.03e-011.00e+00-0.645139727
GO:0044281small molecule metabolic process8.50e-011.00e+00-0.860135844
GO:0006351transcription, DNA-templated9.14e-011.00e+00-1.2101471076
GO:0005886plasma membrane9.18e-011.00e+00-0.9402461784
GO:0016020membrane9.38e-011.00e+00-1.3761561207