int-snw-892

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.968 5.68e-17 8.94e-05 1.03e-03
chia-screen-data-Fav-int-snw-892 subnetwork

Genes (17)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
HCFC1 3054 40-2.9253.44971YesYes
[ CCNC ] 892 1-1.7262.968101--
MED19 219541 30-2.6573.449115Yes-
CNOT1 23019 1-2.3472.96890Yes-
MED28 80306 16-2.4043.21680Yes-
MED13L 23389 12-2.5503.15921Yes-
YAP1 10413 94-4.2563.53853Yes-
POU5F1 5460 133-5.1483.538179YesYes
PSMD2 5708 47-4.1723.157386YesYes
EIF2S2 8894 9-2.9992.96881YesYes
LUC7L3 51747 33-3.5233.44918Yes-
TADA2B 93624 11-3.0613.08219Yes-
EIF2B2 8892 8-2.4622.96895YesYes
MED12 9968 14-2.4653.20665Yes-
NAP1L4 4676 4-1.9473.119187--
SRSF3 6428 73-2.9923.53854Yes-
DDIT3 1649 60-2.8253.504343YesYes

Interactions (23)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
EIF2B2 8892 TADA2B 93624 pp -- int.I2D: BioGrid_Fly, BIND_Fly, FlyLow, IntAct_Fly, MINT_Fly
CCNC 892 EIF2B2 8892 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
MED28 80306 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
YAP1 10413 MED28 80306 pp -- int.I2D: MINT;
int.Mint: MI:0915(physical association)
SRSF3 6428 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
DDIT3 1649 NAP1L4 4676 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
CCNC 892 CNOT1 23019 pp -- int.I2D: BioGrid_Yeast
HCFC1 3054 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
PSMD2 5708 CNOT1 23019 pp -- int.I2D: YeastLow
CCNC 892 MED12 9968 pp -- int.I2D: BioGrid
CCNC 892 MED28 80306 pp -- int.I2D: BioGrid
MED12 9968 MED28 80306 pp -- int.I2D: BioGrid
MED12 9968 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
PSMD2 5708 EIF2B2 8892 pp -- int.I2D: IntAct_Yeast
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
HCFC1 3054 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
CCNC 892 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
LUC7L3 51747 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
CCNC 892 NAP1L4 4676 pp -- int.I2D: BioGrid_Yeast
EIF2B2 8892 EIF2S2 8894 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh
MED13L 23389 MED28 80306 pp -- int.I2D: BioGrid
MED13L 23389 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
CCNC 892 MED13L 23389 pp -- int.I2D: IntAct_Fly, MINT_Fly

Related GO terms (218)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0016592mediator complex3.79e-105.46e-066.92151035
GO:0010467gene expression3.44e-074.97e-033.343845669
GO:0001104RNA polymerase II transcription cofactor activity7.26e-061.05e-016.2693833
GO:0005654nucleoplasm1.29e-051.86e-012.6498641082
GO:0070461SAGA-type complex1.30e-051.88e-018.407225
GO:0006366transcription from RNA polymerase II promoter9.36e-051.00e+003.340530419
GO:0042789mRNA transcription from RNA polymerase II promoter1.01e-041.00e+007.0282213
GO:0014003oligodendrocyte development2.45e-041.00e+006.4072520
GO:0006355regulation of transcription, DNA-templated6.86e-041.00e+002.352643997
GO:0005515protein binding7.59e-041.00e+000.979141986024
GO:0044822poly(A) RNA binding9.31e-041.00e+002.2696501056
GO:0044212transcription regulatory region DNA binding9.36e-041.00e+003.921317168
GO:0060795cell fate commitment involved in formation of primary germ layer1.18e-031.00e+009.729111
GO:2000016negative regulation of determination of dorsal identity1.18e-031.00e+009.729111
GO:0090308regulation of methylation-dependent chromatin silencing1.18e-031.00e+009.729111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway1.18e-031.00e+009.729111
GO:0060965negative regulation of gene silencing by miRNA1.18e-031.00e+009.729111
GO:0006367transcription initiation from RNA polymerase II promoter1.22e-031.00e+003.790322184
GO:0019827stem cell maintenance1.37e-031.00e+005.1742747
GO:0003743translation initiation factor activity1.49e-031.00e+005.1142749
GO:0045944positive regulation of transcription from RNA polymerase II promoter1.72e-031.00e+002.427541789
GO:0060242contact inhibition2.36e-031.00e+008.729112
GO:0019046release from viral latency2.36e-031.00e+008.729122
GO:0002176male germ cell proliferation2.36e-031.00e+008.729112
GO:0009786regulation of asymmetric cell division2.36e-031.00e+008.729112
GO:0044324regulation of transcription involved in anterior/posterior axis specification2.36e-031.00e+008.729112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress2.36e-031.00e+008.729112
GO:0003713transcription coactivator activity2.51e-031.00e+003.425324237
GO:0005850eukaryotic translation initiation factor 2 complex3.53e-031.00e+008.144113
GO:0060913cardiac cell fate determination3.53e-031.00e+008.144113
GO:0003130BMP signaling pathway involved in heart induction3.53e-031.00e+008.144113
GO:0090245axis elongation involved in somitogenesis3.53e-031.00e+008.144113
GO:0014044Schwann cell development4.71e-031.00e+007.729114
GO:0051716cellular response to stimulus4.71e-031.00e+007.729144
GO:0051151negative regulation of smooth muscle cell differentiation4.71e-031.00e+007.729114
GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activity4.71e-031.00e+007.729134
GO:0001714endodermal cell fate specification5.88e-031.00e+007.407115
GO:0043620regulation of DNA-templated transcription in response to stress5.88e-031.00e+007.407115
GO:0010606positive regulation of cytoplasmic mRNA processing body assembly5.88e-031.00e+007.407115
GO:0003682chromatin binding6.20e-031.00e+002.960319327
GO:0005851eukaryotic translation initiation factor 2B complex7.05e-031.00e+007.144146
GO:0006325chromatin organization8.33e-031.00e+003.846212118
GO:0001955blood vessel maturation9.39e-031.00e+006.729118
GO:0048387negative regulation of retinoic acid receptor signaling pathway9.39e-031.00e+006.729128
GO:0070688MLL5-L complex9.39e-031.00e+006.729118
GO:0043254regulation of protein complex assembly9.39e-031.00e+006.729118
GO:0006413translational initiation1.02e-021.00e+003.69527131
GO:0043995histone acetyltransferase activity (H4-K5 specific)1.06e-021.00e+006.559159
GO:0046972histone acetyltransferase activity (H4-K16 specific)1.06e-021.00e+006.559159
GO:0019509L-methionine biosynthetic process from methylthioadenosine1.06e-021.00e+006.559139
GO:0048188Set1C/COMPASS complex1.06e-021.00e+006.559149
GO:0006983ER overload response1.06e-021.00e+006.559119
GO:0016591DNA-directed RNA polymerase II, holoenzyme1.06e-021.00e+006.559129
GO:0043996histone acetyltransferase activity (H4-K8 specific)1.06e-021.00e+006.559159
GO:0035413positive regulation of catenin import into nucleus1.17e-021.00e+006.4071210
GO:0060071Wnt signaling pathway, planar cell polarity pathway1.17e-021.00e+006.4071110
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway1.17e-021.00e+006.4071210
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay1.17e-021.00e+006.4071210
GO:0042974retinoic acid receptor binding1.29e-021.00e+006.2691111
GO:0004535poly(A)-specific ribonuclease activity1.29e-021.00e+006.2691211
GO:2000036regulation of stem cell maintenance1.29e-021.00e+006.2691111
GO:0045662negative regulation of myoblast differentiation1.29e-021.00e+006.2691311
GO:0060391positive regulation of SMAD protein import into nucleus1.29e-021.00e+006.2691411
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening1.29e-021.00e+006.2691211
GO:0006974cellular response to DNA damage stimulus1.34e-021.00e+003.49027151
GO:0005838proteasome regulatory particle1.41e-021.00e+006.1441112
GO:0035198miRNA binding1.41e-021.00e+006.1441112
GO:0071480cellular response to gamma radiation1.52e-021.00e+006.0281113
GO:0030914STAGA complex1.52e-021.00e+006.0281313
GO:0030234enzyme regulator activity1.52e-021.00e+006.0281213
GO:0030518intracellular steroid hormone receptor signaling pathway1.64e-021.00e+005.9211614
GO:0005685U1 snRNP1.64e-021.00e+005.9211114
GO:0044267cellular protein metabolic process1.70e-021.00e+002.425320474
GO:0016607nuclear speck1.71e-021.00e+003.302212172
GO:0043981histone H4-K5 acetylation1.75e-021.00e+005.8221515
GO:0042809vitamin D receptor binding1.75e-021.00e+005.8221615
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.75e-021.00e+005.8221315
GO:0001824blastocyst development1.75e-021.00e+005.8221215
GO:0043982histone H4-K8 acetylation1.75e-021.00e+005.8221515
GO:0030014CCR4-NOT complex1.75e-021.00e+005.8221115
GO:0006376mRNA splice site selection1.75e-021.00e+005.8221115
GO:0005829cytosol1.79e-021.00e+001.2517862496
GO:0003714transcription corepressor activity1.82e-021.00e+003.253211178
GO:0043274phospholipase binding1.87e-021.00e+005.7291116
GO:0042176regulation of protein catabolic process1.87e-021.00e+005.7291216
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription1.87e-021.00e+005.7291216
GO:0001829trophectodermal cell differentiation1.99e-021.00e+005.6411217
GO:0022624proteasome accessory complex1.99e-021.00e+005.6411117
GO:0043984histone H4-K16 acetylation2.22e-021.00e+005.4811519
GO:0032757positive regulation of interleukin-8 production2.33e-021.00e+005.4071120
GO:0000123histone acetyltransferase complex2.45e-021.00e+005.3361621
GO:0045787positive regulation of cell cycle2.56e-021.00e+005.2691222
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription2.56e-021.00e+005.2691422
GO:0030864cortical actin cytoskeleton2.68e-021.00e+005.2051123
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress2.68e-021.00e+005.2051123
GO:0016071mRNA metabolic process2.78e-021.00e+002.92828223
GO:0008135translation factor activity, nucleic acid binding2.79e-021.00e+005.1441324
GO:0008380RNA splicing2.89e-021.00e+002.896222228
GO:0031047gene silencing by RNA2.91e-021.00e+005.0851225
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening2.91e-021.00e+005.0851325
GO:0006412translation2.94e-021.00e+002.88328230
GO:0035329hippo signaling3.02e-021.00e+005.0281526
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic3.02e-021.00e+005.0281226
GO:0051209release of sequestered calcium ion into cytosol3.02e-021.00e+005.0281126
GO:0046966thyroid hormone receptor binding3.02e-021.00e+005.0281626
GO:0030331estrogen receptor binding3.14e-021.00e+004.9741227
GO:0071339MLL1 complex3.14e-021.00e+004.9741627
GO:0008134transcription factor binding3.23e-021.00e+002.810218242
GO:0016070RNA metabolic process3.35e-021.00e+002.78028247
GO:0042594response to starvation3.59e-021.00e+004.7741431
GO:1903507negative regulation of nucleic acid-templated transcription3.71e-021.00e+004.7291232
GO:0006357regulation of transcription from RNA polymerase II promoter3.79e-021.00e+002.684223264
GO:0016020membrane3.99e-021.00e+001.3355461681
GO:0042552myelination4.05e-021.00e+004.5991435
GO:0030178negative regulation of Wnt signaling pathway4.05e-021.00e+004.5991435
GO:0006446regulation of translational initiation4.16e-021.00e+004.5591436
GO:0001541ovarian follicle development4.28e-021.00e+004.5191237
GO:0009408response to heat4.61e-021.00e+004.4071640
GO:0035019somatic stem cell maintenance4.61e-021.00e+004.4071640
GO:0003700sequence-specific DNA binding transcription factor activity4.64e-021.00e+001.864339699
GO:0030521androgen receptor signaling pathway4.73e-021.00e+004.3711541
GO:0031124mRNA 3'-end processing4.84e-021.00e+004.3361242
GO:0003677DNA binding4.95e-021.00e+001.4784491218
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity4.95e-021.00e+004.3021743
GO:0003712transcription cofactor activity5.06e-021.00e+004.2691844
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity5.18e-021.00e+004.2371245
GO:0043434response to peptide hormone5.18e-021.00e+004.2371545
GO:0006369termination of RNA polymerase II transcription5.18e-021.00e+004.2371245
GO:0043525positive regulation of neuron apoptotic process5.29e-021.00e+004.2051446
GO:0005778peroxisomal membrane5.40e-021.00e+004.1741147
GO:0005634nucleus5.52e-021.00e+000.74491594559
GO:0006521regulation of cellular amino acid metabolic process5.74e-021.00e+004.0851150
GO:0006986response to unfolded protein5.74e-021.00e+004.0851450
GO:0034976response to endoplasmic reticulum stress5.85e-021.00e+004.0561251
GO:0045454cell redox homeostasis5.85e-021.00e+004.0561151
GO:0009611response to wounding5.96e-021.00e+004.0281552
GO:0003723RNA binding6.03e-021.00e+002.311218342
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding6.07e-021.00e+004.0011553
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay6.07e-021.00e+004.0011453
GO:0043565sequence-specific DNA binding6.16e-021.00e+002.294211346
GO:0000932cytoplasmic mRNA processing body6.18e-021.00e+003.9741454
GO:0000502proteasome complex6.62e-021.00e+003.8711358
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity6.73e-021.00e+003.8461659
GO:0008013beta-catenin binding6.85e-021.00e+003.8221960
GO:0006406mRNA export from nucleus6.96e-021.00e+003.7981461
GO:0006987activation of signaling protein activity involved in unfolded protein response6.96e-021.00e+003.7981261
GO:0006417regulation of translation7.07e-021.00e+003.7741262
GO:0009749response to glucose7.29e-021.00e+003.7291764
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest7.29e-021.00e+003.7291164
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.40e-021.00e+003.7061265
GO:0010468regulation of gene expression7.72e-021.00e+003.6411268
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.94e-021.00e+003.5991270
GO:0005085guanyl-nucleotide exchange factor activity8.05e-021.00e+003.5791571
GO:0006334nucleosome assembly8.16e-021.00e+003.5591372
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent8.16e-021.00e+003.5591172
GO:0003729mRNA binding8.16e-021.00e+003.5591472
GO:0006351transcription, DNA-templated8.31e-021.00e+001.2314571446
GO:0001843neural tube closure8.38e-021.00e+003.5191274
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity8.38e-021.00e+003.5191474
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle8.38e-021.00e+003.5191274
GO:0008584male gonad development8.49e-021.00e+003.5001375
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process8.49e-021.00e+003.5001175
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I8.49e-021.00e+003.5001175
GO:0060070canonical Wnt signaling pathway8.49e-021.00e+003.5001475
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process8.92e-021.00e+003.4251279
GO:0030968endoplasmic reticulum unfolded protein response8.92e-021.00e+003.4251279
GO:0009653anatomical structure morphogenesis9.35e-021.00e+003.3541283
GO:0090090negative regulation of canonical Wnt signaling pathway9.67e-021.00e+003.3021886
GO:0050821protein stabilization9.89e-021.00e+003.2691388
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.03e-011.00e+003.2051192
GO:0005770late endosome1.04e-011.00e+003.1891293
GO:0051082unfolded protein binding1.04e-011.00e+003.1891793
GO:0045893positive regulation of transcription, DNA-templated1.07e-011.00e+001.828224478
GO:0007417central nervous system development1.07e-011.00e+003.1441596
GO:0000209protein polyubiquitination1.28e-011.00e+002.87113116
GO:0007219Notch signaling pathway1.32e-011.00e+002.82215120
GO:0007050cell cycle arrest1.37e-011.00e+002.77415124
GO:0007179transforming growth factor beta receptor signaling pathway1.41e-011.00e+002.729111128
GO:0000122negative regulation of transcription from RNA polymerase II promoter1.44e-011.00e+001.574237570
GO:0016055Wnt signaling pathway1.51e-011.00e+002.62014138
GO:0007507heart development1.52e-011.00e+002.61017139
GO:0010628positive regulation of gene expression1.59e-011.00e+002.53917146
GO:0000082G1/S transition of mitotic cell cycle1.62e-011.00e+002.50913149
GO:0042981regulation of apoptotic process1.63e-011.00e+002.50014150
GO:0008022protein C-terminus binding1.74e-011.00e+002.39818161
GO:0000398mRNA splicing, via spliceosome1.77e-011.00e+002.371115164
GO:0034641cellular nitrogen compound metabolic process1.84e-011.00e+002.31112171
GO:0007049cell cycle1.87e-011.00e+002.28616174
GO:0005667transcription factor complex1.88e-011.00e+002.277117175
GO:0031625ubiquitin protein ligase binding1.90e-011.00e+002.25315178
GO:0019904protein domain specific binding1.91e-011.00e+002.24518179
GO:0043547positive regulation of GTPase activity1.92e-011.00e+002.23719180
GO:0004872receptor activity2.01e-011.00e+002.16618189
GO:0001701in utero embryonic development2.12e-011.00e+002.07818201
GO:0043025neuronal cell body2.53e-011.00e+001.79219245
GO:0000166nucleotide binding2.65e-011.00e+001.712113259
GO:0005737cytoplasm2.70e-011.00e+000.43461243767
GO:0003779actin binding2.71e-011.00e+001.673110266
GO:0005730nucleolus3.04e-011.00e+000.6333661641
GO:0005525GTP binding3.09e-011.00e+001.452112310
GO:0019901protein kinase binding3.15e-011.00e+001.420118317
GO:0008283cell proliferation3.24e-011.00e+001.371114328
GO:0005925focal adhesion3.54e-011.00e+001.21319366
GO:0046982protein heterodimerization activity3.65e-011.00e+001.15918380
GO:0000278mitotic cell cycle3.73e-011.00e+001.118115391
GO:0045892negative regulation of transcription, DNA-templated3.90e-011.00e+001.039124413
GO:0043066negative regulation of apoptotic process3.98e-011.00e+001.001116424
GO:0042802identical protein binding4.40e-011.00e+000.810119484
GO:0016032viral process4.74e-011.00e+000.668126534
GO:0006915apoptotic process4.87e-011.00e+000.612112555
GO:0005615extracellular space6.89e-011.00e+00-0.174120957
GO:0008270zinc ion binding7.04e-011.00e+00-0.233127997
GO:0005739mitochondrion7.05e-011.00e+00-0.234123998
GO:0044281small molecule metabolic process7.75e-011.00e+00-0.5131201211
GO:0005524ATP binding7.99e-011.00e+00-0.6131311298
GO:0046872metal ion binding8.01e-011.00e+00-0.6231291307
GO:0070062extracellular vesicular exosome9.55e-011.00e+00-1.5001572400
GO:0005886plasma membrane9.65e-011.00e+00-1.6061492582