Related GO terms (2283)

Accession number Name Occurrences in all snw genes Occurrences in all int/reg genes
GO:0009897external side of plasma membrane3177
GO:0045334clathrin-coated endocytic vesicle15
GO:0014013regulation of gliogenesis11
GO:0051594detection of glucose13
GO:0006285base-excision repair, AP site formation18
GO:0005747mitochondrial respiratory chain complex I139
GO:1901253negative regulation of intracellular transport of viral material12
GO:0044237cellular metabolic process2117
GO:0005769early endosome1152
GO:0032088negative regulation of NF-kappaB transcription factor activity363
GO:0014044Schwann cell development14
GO:0008750NAD(P)+ transhydrogenase (AB-specific) activity11
GO:0030332cyclin binding118
GO:0001558regulation of cell growth161
GO:0007492endoderm development221
GO:0008092cytoskeletal protein binding147
GO:0002053positive regulation of mesenchymal cell proliferation132
GO:0007286spermatid development141
GO:0008360regulation of cell shape4103
GO:0007096regulation of exit from mitosis17
GO:0072350tricarboxylic acid metabolic process13
GO:0002064epithelial cell development18
GO:0006537glutamate biosynthetic process15
GO:0097202activation of cysteine-type endopeptidase activity18
GO:0030168platelet activation6205
GO:0003725double-stranded RNA binding152
GO:0043508negative regulation of JUN kinase activity113
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen15
GO:0070126mitochondrial translational termination11
GO:0033209tumor necrosis factor-mediated signaling pathway128
GO:0001656metanephros development127
GO:0060215primitive hemopoiesis13
GO:0006990positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response23
GO:0051092positive regulation of NF-kappaB transcription factor activity5124
GO:0031047gene silencing by RNA225
GO:1902044regulation of Fas signaling pathway11
GO:0043204perikaryon155
GO:0045171intercellular bridge130
GO:0016601Rac protein signal transduction117
GO:0060071Wnt signaling pathway, planar cell polarity pathway110
GO:0048844artery morphogenesis121
GO:0032781positive regulation of ATPase activity124
GO:0060325face morphogenesis131
GO:0002248connective tissue replacement involved in inflammatory response wound healing13
GO:0030316osteoclast differentiation222
GO:0060242contact inhibition12
GO:0034191apolipoprotein A-I receptor binding13
GO:1990138neuron projection extension15
GO:0070628proteasome binding110
GO:0001102RNA polymerase II activating transcription factor binding136
GO:0003281ventricular septum development114
GO:0046548retinal rod cell development17
GO:0045892negative regulation of transcription, DNA-templated24413
GO:0046058cAMP metabolic process13
GO:0008017microtubule binding2147
GO:0042100B cell proliferation121
GO:0016331morphogenesis of embryonic epithelium110
GO:0036336dendritic cell migration15
GO:0007617mating behavior18
GO:0051084'de novo' posttranslational protein folding537
GO:0033276transcription factor TFTC complex414
GO:0032998Fc-epsilon receptor I complex12
GO:007188914-3-3 protein binding218
GO:0008283cell proliferation14328
GO:0032922circadian regulation of gene expression149
GO:0031122cytoplasmic microtubule organization118
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage249
GO:0005070SH3/SH2 adaptor activity248
GO:0046914transition metal ion binding13
GO:0030336negative regulation of cell migration178
GO:0060312regulation of blood vessel remodeling12
GO:0021702cerebellar Purkinje cell differentiation112
GO:0008284positive regulation of cell proliferation10382
GO:0030048actin filament-based movement114
GO:0043969histone H2B acetylation11
GO:0045747positive regulation of Notch signaling pathway121
GO:0060364frontal suture morphogenesis14
GO:0004844uracil DNA N-glycosylase activity14
GO:000925810-formyltetrahydrofolate catabolic process12
GO:0034134toll-like receptor 2 signaling pathway473
GO:0043627response to estrogen556
GO:0000422mitochondrion degradation115
GO:0051046regulation of secretion12
GO:0003160endocardium morphogenesis12
GO:0030277maintenance of gastrointestinal epithelium211
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay4114
GO:0017112Rab guanyl-nucleotide exchange factor activity120
GO:2000483negative regulation of interleukin-8 secretion12
GO:0050733RS domain binding16
GO:0045944positive regulation of transcription from RNA polymerase II promoter41789
GO:0001518voltage-gated sodium channel complex110
GO:1901297positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment11
GO:0007597blood coagulation, intrinsic pathway218
GO:0031011Ino80 complex614
GO:0055114oxidation-reduction process10420
GO:0048733sebaceous gland development15
GO:0032703negative regulation of interleukin-2 production110
GO:0034162toll-like receptor 9 signaling pathway472
GO:0046732active induction of host immune response by virus12
GO:0008887glycerate kinase activity11
GO:0003712transcription cofactor activity844
GO:0007229integrin-mediated signaling pathway378
GO:0034616response to laminar fluid shear stress18
GO:0007623circadian rhythm153
GO:0030593neutrophil chemotaxis241
GO:0005882intermediate filament261
GO:0010388cullin deneddylation59
GO:0046688response to copper ion113
GO:0070509calcium ion import124
GO:0043966histone H3 acetylation545
GO:0035035histone acetyltransferase binding119
GO:0040019positive regulation of embryonic development16
GO:0060661submandibular salivary gland formation12
GO:0031982vesicle3131
GO:0032967positive regulation of collagen biosynthetic process321
GO:0090043regulation of tubulin deacetylation22
GO:0003697single-stranded DNA binding568
GO:0072357PTW/PP1 phosphatase complex27
GO:0032429regulation of phospholipase A2 activity12
GO:0005125cytokine activity2138
GO:0030154cell differentiation5301
GO:0000398mRNA splicing, via spliceosome15164
GO:0072593reactive oxygen species metabolic process231
GO:0043066negative regulation of apoptotic process16424
GO:2000249regulation of actin cytoskeleton reorganization112
GO:0060033anatomical structure regression15
GO:0043008ATP-dependent protein binding17
GO:0002474antigen processing and presentation of peptide antigen via MHC class I192
GO:0034450ubiquitin-ubiquitin ligase activity18
GO:0010544negative regulation of platelet activation19
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening325
GO:0030225macrophage differentiation215
GO:0034765regulation of ion transmembrane transport298
GO:1902187negative regulation of viral release from host cell115
GO:0019904protein domain specific binding8179
GO:0042594response to starvation431
GO:0019899enzyme binding9277
GO:0001649osteoblast differentiation592
GO:0019865immunoglobulin binding12
GO:0006360transcription from RNA polymerase I promoter330
GO:0060789hair follicle placode formation26
GO:0009749response to glucose764
GO:0005654nucleoplasm641082
GO:0006458'de novo' protein folding13
GO:0016208AMP binding19
GO:0007507heart development7139
GO:0000395mRNA 5'-splice site recognition14
GO:0031018endocrine pancreas development235
GO:0009408response to heat640
GO:0043531ADP binding328
GO:0043029T cell homeostasis121
GO:0003433chondrocyte development involved in endochondral bone morphogenesis11
GO:0018105peptidyl-serine phosphorylation269
GO:0000776kinetochore563
GO:0030032lamellipodium assembly129
GO:0014070response to organic cyclic compound143
GO:0000922spindle pole487
GO:0032027myosin light chain binding13
GO:0007088regulation of mitosis118
GO:0016045detection of bacterium114
GO:0036064ciliary basal body257
GO:0048536spleen development131
GO:0007163establishment or maintenance of cell polarity224
GO:0030183B cell differentiation154
GO:0019789SUMO ligase activity111
GO:0071800podosome assembly14
GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activity34
GO:0003308negative regulation of Wnt signaling pathway involved in heart development13
GO:0042991transcription factor import into nucleus11
GO:0071230cellular response to amino acid stimulus142
GO:0030218erythrocyte differentiation137
GO:0071013catalytic step 2 spliceosome778
GO:0045765regulation of angiogenesis224
GO:0032851positive regulation of Rab GTPase activity253
GO:0051301cell division281
GO:0021695cerebellar cortex development16
GO:0030529ribonucleoprotein complex5112
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process279
GO:0050982detection of mechanical stimulus17
GO:0016514SWI/SNF complex115
GO:0035278negative regulation of translation involved in gene silencing by miRNA19
GO:0007346regulation of mitotic cell cycle129
GO:0006260DNA replication3121
GO:0043274phospholipase binding116
GO:0001890placenta development331
GO:0035019somatic stem cell maintenance640
GO:0003690double-stranded DNA binding386
GO:0008406gonad development125
GO:0030193regulation of blood coagulation115
GO:0019815B cell receptor complex13
GO:0031234extrinsic component of cytoplasmic side of plasma membrane124
GO:0070728leucine binding14
GO:0003906DNA-(apurinic or apyrimidinic site) lyase activity210
GO:0071104response to interleukin-912
GO:0016255attachment of GPI anchor to protein17
GO:0048471perinuclear region of cytoplasm8502
GO:0005916fascia adherens113
GO:0007275multicellular organismal development7316
GO:0070542response to fatty acid114
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formation19
GO:0008203cholesterol metabolic process257
GO:0019226transmission of nerve impulse114
GO:0003730mRNA 3'-UTR binding226
GO:0007283spermatogenesis3262
GO:0035909aorta morphogenesis112
GO:0051019mitogen-activated protein kinase binding213
GO:0085029extracellular matrix assembly16
GO:0016021integral component of membrane171982
GO:0050770regulation of axonogenesis226
GO:0043022ribosome binding127
GO:0034136negative regulation of toll-like receptor 2 signaling pathway13
GO:0034401regulation of transcription by chromatin organization11
GO:0010596negative regulation of endothelial cell migration114
GO:0030017sarcomere234
GO:2001222regulation of neuron migration18
GO:0007435salivary gland morphogenesis16
GO:0050905neuromuscular process112
GO:0032403protein complex binding6183
GO:0032453histone demethylase activity (H3-K4 specific)14
GO:0061053somite development110
GO:0019370leukotriene biosynthetic process113
GO:0032587ruffle membrane370
GO:0032092positive regulation of protein binding238
GO:0030644cellular chloride ion homeostasis15
GO:0000012single strand break repair37
GO:0014003oligodendrocyte development520
GO:0005581collagen trimer138
GO:0060751branch elongation involved in mammary gland duct branching11
GO:0006605protein targeting135
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen16
GO:0031256leading edge membrane15
GO:0048147negative regulation of fibroblast proliferation122
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I175
GO:0030014CCR4-NOT complex115
GO:0071339MLL1 complex627
GO:0030889negative regulation of B cell proliferation113
GO:0032039integrator complex113
GO:1903507negative regulation of nucleic acid-templated transcription232
GO:0008079translation termination factor activity11
GO:0005791rough endoplasmic reticulum135
GO:0045638negative regulation of myeloid cell differentiation116
GO:0045879negative regulation of smoothened signaling pathway122
GO:0050693LBD domain binding14
GO:0086010membrane depolarization during action potential225
GO:0051770positive regulation of nitric-oxide synthase biosynthetic process114
GO:0005868cytoplasmic dynein complex113
GO:0016197endosomal transport257
GO:0002224toll-like receptor signaling pathway4109
GO:0034235GPI anchor binding17
GO:0005080protein kinase C binding143
GO:0030870Mre11 complex16
GO:0007265Ras protein signal transduction375
GO:0034146toll-like receptor 5 signaling pathway465
GO:0008217regulation of blood pressure157
GO:0072384organelle transport along microtubule14
GO:0045859regulation of protein kinase activity126
GO:0006069ethanol oxidation110
GO:0071222cellular response to lipopolysaccharide481
GO:0007500mesodermal cell fate determination13
GO:0043405regulation of MAP kinase activity15
GO:0051480cytosolic calcium ion homeostasis118
GO:0060396growth hormone receptor signaling pathway18
GO:0050681androgen receptor binding138
GO:0032853positive regulation of Ran GTPase activity16
GO:0071276cellular response to cadmium ion113
GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor14
GO:0004823leucine-tRNA ligase activity12
GO:0001702gastrulation with mouth forming second121
GO:0050786RAGE receptor binding111
GO:0071375cellular response to peptide hormone stimulus214
GO:0055100adiponectin binding13
GO:0030141secretory granule462
GO:0017056structural constituent of nuclear pore29
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle274
GO:0000724double-strand break repair via homologous recombination255
GO:0006406mRNA export from nucleus461
GO:0006475internal protein amino acid acetylation17
GO:0035307positive regulation of protein dephosphorylation117
GO:0006369termination of RNA polymerase II transcription245
GO:0032119sequestering of zinc ion13
GO:0033211adiponectin-activated signaling pathway16
GO:0051497negative regulation of stress fiber assembly19
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle270
GO:0021889olfactory bulb interneuron differentiation14
GO:0004392heme oxygenase (decyclizing) activity22
GO:0034142toll-like receptor 4 signaling pathway496
GO:0072307regulation of metanephric nephron tubule epithelial cell differentiation15
GO:0042060wound healing264
GO:0019894kinesin binding128
GO:0005200structural constituent of cytoskeleton691
GO:0044324regulation of transcription involved in anterior/posterior axis specification12
GO:0030501positive regulation of bone mineralization129
GO:0006446regulation of translational initiation436
GO:0070374positive regulation of ERK1 and ERK2 cascade1106
GO:0043313regulation of neutrophil degranulation12
GO:0010744positive regulation of macrophage derived foam cell differentiation114
GO:0032353negative regulation of hormone biosynthetic process11
GO:0021766hippocampus development138
GO:0030199collagen fibril organization237
GO:0006289nucleotide-excision repair568
GO:0021750vestibular nucleus development12
GO:0019100male germ-line sex determination12
GO:0004656procollagen-proline 4-dioxygenase activity14
GO:0005496steroid binding115
GO:0021762substantia nigra development444
GO:0008152metabolic process1258
GO:0004832valine-tRNA ligase activity12
GO:0006184GTP catabolic process7214
GO:0002181cytoplasmic translation16
GO:0016607nuclear speck12172
GO:0042054histone methyltransferase activity38
GO:0008024positive transcription elongation factor complex b15
GO:0003924GTPase activity7197
GO:0002544chronic inflammatory response19
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development17
GO:0005743mitochondrial inner membrane6277
GO:0008150biological_process4389
GO:0030518intracellular steroid hormone receptor signaling pathway614
GO:0007077mitotic nuclear envelope disassembly436
GO:0070765gamma-secretase complex12
GO:0000278mitotic cell cycle15391
GO:0006878cellular copper ion homeostasis112
GO:0043194axon initial segment110
GO:0008347glial cell migration17
GO:0060745mammary gland branching involved in pregnancy13
GO:0070412R-SMAD binding121
GO:0008746NAD(P)+ transhydrogenase activity11
GO:0032886regulation of microtubule-based process112
GO:0007267cell-cell signaling2219
GO:1901315negative regulation of histone H2A K63-linked ubiquitination13
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle265
GO:0006379mRNA cleavage19
GO:0016071mRNA metabolic process8223
GO:0030855epithelial cell differentiation161
GO:0050930induction of positive chemotaxis114
GO:0001829trophectodermal cell differentiation217
GO:0046983protein dimerization activity5118
GO:0071354cellular response to interleukin-627
GO:0051988regulation of attachment of spindle microtubules to kinetochore27
GO:0001570vasculogenesis256
GO:0051292nuclear pore complex assembly48
GO:0005922connexon complex113
GO:2000096positive regulation of Wnt signaling pathway, planar cell polarity pathway15
GO:0001105RNA polymerase II transcription coactivator activity224
GO:0019767IgE receptor activity13
GO:0048820hair follicle maturation12
GO:0004708MAP kinase kinase activity113
GO:0016155formyltetrahydrofolate dehydrogenase activity12
GO:0034613cellular protein localization244
GO:0032797SMN complex111
GO:0010575positive regulation vascular endothelial growth factor production121
GO:0006950response to stress246
GO:0050919negative chemotaxis117
GO:0050766positive regulation of phagocytosis123
GO:0007179transforming growth factor beta receptor signaling pathway11128
GO:0005829cytosol862496
GO:0005667transcription factor complex17175
GO:0006144purine nucleobase metabolic process130
GO:0043206extracellular fibril organization19
GO:0060348bone development233
GO:0009890negative regulation of biosynthetic process12
GO:0016222procollagen-proline 4-dioxygenase complex13
GO:0030971receptor tyrosine kinase binding233
GO:0034971histone H3-R17 methylation11
GO:0010718positive regulation of epithelial to mesenchymal transition425
GO:0042542response to hydrogen peroxide139
GO:0048589developmental growth225
GO:0017022myosin binding217
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis274
GO:0050821protein stabilization388
GO:0032689negative regulation of interferon-gamma production124
GO:0003707steroid hormone receptor activity145
GO:0006385transcription elongation from RNA polymerase III promoter318
GO:0000339RNA cap binding18
GO:0034720histone H3-K4 demethylation16
GO:0000188inactivation of MAPK activity127
GO:0048936peripheral nervous system neuron axonogenesis13
GO:0004693cyclin-dependent protein serine/threonine kinase activity131
GO:0045008depyrimidination15
GO:0045446endothelial cell differentiation17
GO:0038031non-canonical Wnt signaling pathway via JNK cascade15
GO:0031996thioesterase binding114
GO:0042074cell migration involved in gastrulation18
GO:0000096sulfur amino acid metabolic process127
GO:0032259methylation157
GO:0005778peroxisomal membrane147
GO:0030520intracellular estrogen receptor signaling pathway418
GO:0060333interferon-gamma-mediated signaling pathway362
GO:0034101erythrocyte homeostasis17
GO:0016589NURF complex16
GO:0045793positive regulation of cell size29
GO:0007005mitochondrion organization130
GO:0005789endoplasmic reticulum membrane9570
GO:0006310DNA recombination765
GO:0016236macroautophagy16
GO:0043200response to amino acid123
GO:0008334histone mRNA metabolic process112
GO:0060633negative regulation of transcription initiation from RNA polymerase II promoter12
GO:0021913regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification12
GO:0045294alpha-catenin binding18
GO:0006907pinocytosis15
GO:0003181atrioventricular valve morphogenesis18
GO:0007040lysosome organization126
GO:0005720nuclear heterochromatin222
GO:0005575cellular_component2279
GO:0016525negative regulation of angiogenesis152
GO:0031726CCR1 chemokine receptor binding16
GO:0016573histone acetylation223
GO:0004842ubiquitin-protein transferase activity5255
GO:0003779actin binding10266
GO:1900127positive regulation of hyaluronan biosynthetic process13
GO:0051222positive regulation of protein transport14
GO:0005096GTPase activator activity2102
GO:0090245axis elongation involved in somitogenesis13
GO:0009786regulation of asymmetric cell division12
GO:0035242protein-arginine omega-N asymmetric methyltransferase activity17
GO:0035725sodium ion transmembrane transport152
GO:0045347negative regulation of MHC class II biosynthetic process15
GO:0031490chromatin DNA binding238
GO:0017015regulation of transforming growth factor beta receptor signaling pathway118
GO:0005869dynactin complex18
GO:0050765negative regulation of phagocytosis17
GO:0060486Clara cell differentiation14
GO:0000578embryonic axis specification17
GO:0043408regulation of MAPK cascade114
GO:0086091regulation of heart rate by cardiac conduction119
GO:0005912adherens junction135
GO:0035264multicellular organism growth267
GO:0006335DNA replication-dependent nucleosome assembly217
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors15
GO:0033523histone H2B ubiquitination18
GO:0060750epithelial cell proliferation involved in mammary gland duct elongation15
GO:0005851eukaryotic translation initiation factor 2B complex46
GO:0051000positive regulation of nitric-oxide synthase activity115
GO:0006355regulation of transcription, DNA-templated43997
GO:0035924cellular response to vascular endothelial growth factor stimulus120
GO:0010956negative regulation of calcidiol 1-monooxygenase activity13
GO:0034341response to interferon-gamma221
GO:0010606positive regulation of cytoplasmic mRNA processing body assembly15
GO:0019900kinase binding152
GO:0015992proton transport129
GO:0009755hormone-mediated signaling pathway118
GO:0031648protein destabilization121
GO:0051219phosphoprotein binding132
GO:0050832defense response to fungus115
GO:0002366leukocyte activation involved in immune response12
GO:0001540beta-amyloid binding127
GO:0007018microtubule-based movement157
GO:0005813centrosome7326
GO:0006890retrograde vesicle-mediated transport, Golgi to ER125
GO:0009060aerobic respiration117
GO:0046638positive regulation of alpha-beta T cell differentiation19
GO:0010467gene expression45669
GO:0034166toll-like receptor 10 signaling pathway465
GO:0042981regulation of apoptotic process4150
GO:0007049cell cycle6174
GO:0051015actin filament binding392
GO:0030513positive regulation of BMP signaling pathway126
GO:0007601visual perception5157
GO:0007224smoothened signaling pathway148
GO:0042157lipoprotein metabolic process136
GO:0070062extracellular vesicular exosome572400
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway125
GO:0030036actin cytoskeleton organization3123
GO:0030148sphingolipid biosynthetic process126
GO:0034056estrogen response element binding14
GO:0014069postsynaptic density1105
GO:0050921positive regulation of chemotaxis113
GO:0071547piP-body14
GO:0004197cysteine-type endopeptidase activity150
GO:0008104protein localization156
GO:0031941filamentous actin222
GO:0005199structural constituent of cell wall11
GO:0042995cell projection360
GO:0050908detection of light stimulus involved in visual perception113
GO:0060068vagina development111
GO:0006895Golgi to endosome transport111
GO:0005506iron ion binding3105
GO:0051151negative regulation of smooth muscle cell differentiation14
GO:0032611interleukin-1 beta production14
GO:0060765regulation of androgen receptor signaling pathway19
GO:0048812neuron projection morphogenesis131
GO:0043044ATP-dependent chromatin remodeling223
GO:0005739mitochondrion23998
GO:0044027hypermethylation of CpG island13
GO:0048041focal adhesion assembly121
GO:0000902cell morphogenesis449
GO:0042552myelination435
GO:0045646regulation of erythrocyte differentiation14
GO:0008432JUN kinase binding16
GO:0050434positive regulation of viral transcription544
GO:0005915zonula adherens19
GO:0050790regulation of catalytic activity169
GO:0007417central nervous system development596
GO:0009887organ morphogenesis586
GO:0072661protein targeting to plasma membrane119
GO:0008601protein phosphatase type 2A regulator activity120
GO:1901666positive regulation of NAD+ ADP-ribosyltransferase activity11
GO:0004768stearoyl-CoA 9-desaturase activity13
GO:0051260protein homooligomerization3145
GO:0046696lipopolysaccharide receptor complex15
GO:0016973poly(A)+ mRNA export from nucleus18
GO:0021983pituitary gland development227
GO:0002052positive regulation of neuroblast proliferation118
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway236
GO:0031063regulation of histone deacetylation14
GO:0097372NAD-dependent histone deacetylase activity (H3-K18 specific)112
GO:0070372regulation of ERK1 and ERK2 cascade217
GO:0006479protein methylation214
GO:0010043response to zinc ion124
GO:0005680anaphase-promoting complex120
GO:0048188Set1C/COMPASS complex49
GO:0042491auditory receptor cell differentiation19
GO:0032764negative regulation of mast cell cytokine production12
GO:0032880regulation of protein localization237
GO:0006461protein complex assembly4111
GO:0003222ventricular trabecula myocardium morphogenesis19
GO:0071456cellular response to hypoxia392
GO:0031072heat shock protein binding233
GO:0042470melanosome291
GO:0045071negative regulation of viral genome replication134
GO:0017145stem cell division17
GO:0046621negative regulation of organ growth111
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway210
GO:0043984histone H4-K16 acetylation519
GO:0031670cellular response to nutrient13
GO:0050870positive regulation of T cell activation117
GO:0016798hydrolase activity, acting on glycosyl bonds17
GO:0001841neural tube formation110
GO:0045666positive regulation of neuron differentiation363
GO:0019898extrinsic component of membrane242
GO:0019838growth factor binding125
GO:0043025neuronal cell body9245
GO:0071560cellular response to transforming growth factor beta stimulus336
GO:0005178integrin binding496
GO:0005887integral component of plasma membrane10888
GO:0046040IMP metabolic process13
GO:0005764lysosome2172
GO:0000790nuclear chromatin6129
GO:0022617extracellular matrix disassembly2107
GO:0007519skeletal muscle tissue development240
GO:2000629negative regulation of miRNA metabolic process11
GO:0030324lung development172
GO:0010944negative regulation of transcription by competitive promoter binding19
GO:0007406negative regulation of neuroblast proliferation16
GO:0060523prostate epithelial cord elongation13
GO:0030424axon4166
GO:0016070RNA metabolic process8247
GO:0006397mRNA processing10160
GO:0008193tRNA guanylyltransferase activity12
GO:0030234enzyme regulator activity213
GO:0043507positive regulation of JUN kinase activity128
GO:0044212transcription regulatory region DNA binding17168
GO:0007568aging2117
GO:0035497cAMP response element binding16
GO:0016323basolateral plasma membrane3135
GO:0050700CARD domain binding18
GO:0070410co-SMAD binding112
GO:0008016regulation of heart contraction130
GO:0019233sensory perception of pain148
GO:0050896response to stimulus240
GO:0032465regulation of cytokinesis114
GO:0000118histone deacetylase complex128
GO:0032835glomerulus development19
GO:0043393regulation of protein binding120
GO:0007398ectoderm development116
GO:0032154cleavage furrow138
GO:0035198miRNA binding112
GO:0021522spinal cord motor neuron differentiation116
GO:0060047heart contraction110
GO:0005525GTP binding12310
GO:0042113B cell activation225
GO:0010494cytoplasmic stress granule230
GO:0043539protein serine/threonine kinase activator activity114
GO:0032735positive regulation of interleukin-12 production225
GO:0044615nuclear pore nuclear basket14
GO:0070208protein heterotrimerization19
GO:0061314Notch signaling involved in heart development19
GO:0030659cytoplasmic vesicle membrane2101
GO:0050775positive regulation of dendrite morphogenesis115
GO:0031589cell-substrate adhesion116
GO:0017070U6 snRNA binding16
GO:0005031tumor necrosis factor-activated receptor activity19
GO:0005578proteinaceous extracellular matrix4160
GO:0000346transcription export complex113
GO:0048617embryonic foregut morphogenesis110
GO:0035094response to nicotine225
GO:0048008platelet-derived growth factor receptor signaling pathway227
GO:0035371microtubule plus-end114
GO:0060311negative regulation of elastin catabolic process11
GO:0003065positive regulation of heart rate by epinephrine11
GO:0044255cellular lipid metabolic process2133
GO:0009451RNA modification11
GO:0060279positive regulation of ovulation13
GO:0051894positive regulation of focal adhesion assembly118
GO:0021796cerebral cortex regionalization15
GO:0071549cellular response to dexamethasone stimulus320
GO:0005518collagen binding254
GO:0051493regulation of cytoskeleton organization116
GO:0035662Toll-like receptor 4 binding14
GO:0001569patterning of blood vessels131
GO:0045667regulation of osteoblast differentiation19
GO:0042809vitamin D receptor binding615
GO:0043588skin development128
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpoint15
GO:0048850hypophysis morphogenesis12
GO:0051087chaperone binding359
GO:0070669response to interleukin-213
GO:0002842positive regulation of T cell mediated immune response to tumor cell11
GO:0071559response to transforming growth factor beta13
GO:0021590cerebellum maturation11
GO:0009168purine ribonucleoside monophosphate biosynthetic process112
GO:0016568chromatin modification498
GO:0070966nuclear-transcribed mRNA catabolic process, no-go decay13
GO:0051291protein heterooligomerization456
GO:0002128tRNA nucleoside ribose methylation11
GO:0050883musculoskeletal movement, spinal reflex action13
GO:0032375negative regulation of cholesterol transport14
GO:0019948SUMO activating enzyme activity12
GO:0032874positive regulation of stress-activated MAPK cascade112
GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response16
GO:0004674protein serine/threonine kinase activity6308
GO:0033268node of Ranvier216
GO:0042754negative regulation of circadian rhythm18
GO:0010804negative regulation of tumor necrosis factor-mediated signaling pathway19
GO:0035064methylated histone binding246
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway471
GO:0045947negative regulation of translational initiation212
GO:0097452GAIT complex14
GO:0045909positive regulation of vasodilation126
GO:0045066regulatory T cell differentiation12
GO:2000016negative regulation of determination of dorsal identity11
GO:1901985positive regulation of protein acetylation11
GO:0007023post-chaperonin tubulin folding pathway25
GO:0004019adenylosuccinate synthase activity12
GO:0001822kidney development378
GO:0009416response to light stimulus113
GO:0043931ossification involved in bone maturation17
GO:0032496response to lipopolysaccharide4121
GO:0051781positive regulation of cell division139
GO:0032720negative regulation of tumor necrosis factor production227
GO:0006368transcription elongation from RNA polymerase II promoter667
GO:0048839inner ear development137
GO:0070064proline-rich region binding118
GO:0006531aspartate metabolic process16
GO:0045055regulated secretory pathway110
GO:0032727positive regulation of interferon-alpha production111
GO:0005793endoplasmic reticulum-Golgi intermediate compartment256
GO:0030326embryonic limb morphogenesis137
GO:0001816cytokine production125
GO:0001955blood vessel maturation18
GO:0050661NADP binding127
GO:0019905syntaxin binding233
GO:0003774motor activity143
GO:0048103somatic stem cell division19
GO:0070816phosphorylation of RNA polymerase II C-terminal domain12
GO:0008026ATP-dependent helicase activity139
GO:0045216cell-cell junction organization254
GO:0002193MAML1-RBP-Jkappa- ICN1 complex13
GO:0002159desmosome assembly14
GO:0070403NAD+ binding111
GO:0031315extrinsic component of mitochondrial outer membrane12
GO:0035925mRNA 3'-UTR AU-rich region binding15
GO:0009395phospholipid catabolic process111
GO:0003987acetate-CoA ligase activity13
GO:0007221positive regulation of transcription of Notch receptor target14
GO:0042589zymogen granule membrane110
GO:0014806smooth muscle hyperplasia12
GO:0006665sphingolipid metabolic process160
GO:0007000nucleolus organization14
GO:0007628adult walking behavior328
GO:0030666endocytic vesicle membrane153
GO:0043235receptor complex299
GO:0001650fibrillar center13
GO:0048291isotype switching to IgG isotypes11
GO:0051607defense response to virus1126
GO:0006351transcription, DNA-templated571446
GO:0003676nucleic acid binding2107
GO:0032500muramyl dipeptide binding11
GO:0006693prostaglandin metabolic process19
GO:0005615extracellular space20957
GO:0043534blood vessel endothelial cell migration110
GO:0031124mRNA 3'-end processing242
GO:0006112energy reserve metabolic process295
GO:0006538glutamate catabolic process14
GO:0043922negative regulation by host of viral transcription112
GO:0051707response to other organism14
GO:0007369gastrulation119
GO:0097057TRAF2-GSTP1 complex11
GO:0043032positive regulation of macrophage activation110
GO:0006805xenobiotic metabolic process2103
GO:0007257activation of JUN kinase activity536
GO:0005865striated muscle thin filament16
GO:0001523retinoid metabolic process148
GO:1901250negative regulation of lung goblet cell differentiation11
GO:0007202activation of phospholipase C activity155
GO:0032982myosin filament115
GO:0010669epithelial structure maintenance14
GO:0010560positive regulation of glycoprotein biosynthetic process13
GO:0051146striated muscle cell differentiation112
GO:0055105ubiquitin-protein transferase inhibitor activity12
GO:0060965negative regulation of gene silencing by miRNA11
GO:0031295T cell costimulation165
GO:0043488regulation of mRNA stability113
GO:0007611learning or memory134
GO:0005746mitochondrial respiratory chain111
GO:0070741response to interleukin-613
GO:0000380alternative mRNA splicing, via spliceosome211
GO:0050727regulation of inflammatory response145
GO:0042384cilium assembly186
GO:0071158positive regulation of cell cycle arrest219
GO:0031519PcG protein complex125
GO:0006200ATP catabolic process2292
GO:0002528regulation of vascular permeability involved in acute inflammatory response12
GO:0050850positive regulation of calcium-mediated signaling119
GO:0030335positive regulation of cell migration5127
GO:0006096glycolytic process338
GO:0002606positive regulation of dendritic cell antigen processing and presentation17
GO:0034244negative regulation of transcription elongation from RNA polymerase II promoter110
GO:0048208COPII vesicle coating115
GO:0035088establishment or maintenance of apical/basal cell polarity15
GO:0090002establishment of protein localization to plasma membrane116
GO:0032760positive regulation of tumor necrosis factor production237
GO:00170053'-tyrosyl-DNA phosphodiesterase activity11
GO:0060795cell fate commitment involved in formation of primary germ layer11
GO:0071345cellular response to cytokine stimulus116
GO:0051154negative regulation of striated muscle cell differentiation13
GO:0002088lens development in camera-type eye124
GO:1900126negative regulation of hyaluronan biosynthetic process13
GO:0043981histone H4-K5 acetylation515
GO:0046976histone methyltransferase activity (H3-K27 specific)14
GO:2000279negative regulation of DNA biosynthetic process18
GO:0030175filopodium150
GO:0010800positive regulation of peptidyl-threonine phosphorylation117
GO:0015758glucose transport455
GO:0008536Ran GTPase binding225
GO:0043392negative regulation of DNA binding426
GO:1900186negative regulation of clathrin-mediated endocytosis11
GO:0006476protein deacetylation19
GO:0002244hematopoietic progenitor cell differentiation154
GO:0061462protein localization to lysosome13
GO:0030901midbrain development129
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex315
GO:0045605negative regulation of epidermal cell differentiation11
GO:0045893positive regulation of transcription, DNA-templated24478
GO:0010225response to UV-C29
GO:0007264small GTPase mediated signal transduction3279
GO:0061383trabecula morphogenesis11
GO:0004709MAP kinase kinase kinase activity218
GO:0001701in utero embryonic development8201
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription559
GO:0061034olfactory bulb mitral cell layer development12
GO:0048484enteric nervous system development110
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II190
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process463
GO:2000780negative regulation of double-strand break repair15
GO:0005102receptor binding2260
GO:0061198fungiform papilla formation13
GO:0050544arachidonic acid binding15
GO:0045454cell redox homeostasis151
GO:0044267cellular protein metabolic process20474
GO:0043279response to alkaloid25
GO:0060334regulation of interferon-gamma-mediated signaling pathway116
GO:0048205COPI coating of Golgi vesicle113
GO:0002674negative regulation of acute inflammatory response17
GO:0042511positive regulation of tyrosine phosphorylation of Stat1 protein19
GO:0030623U5 snRNA binding11
GO:0035994response to muscle stretch13
GO:0005856cytoskeleton9291
GO:0008276protein methyltransferase activity15
GO:0000910cytokinesis251
GO:0000375RNA splicing, via transesterification reactions325
GO:0070373negative regulation of ERK1 and ERK2 cascade131
GO:0035308negative regulation of protein dephosphorylation13
GO:0070670response to interleukin-416
GO:0060684epithelial-mesenchymal cell signaling14
GO:0005243gap junction channel activity18
GO:0043547positive regulation of GTPase activity9180
GO:0006405RNA export from nucleus23
GO:0072376protein activation cascade11
GO:0030914STAGA complex313
GO:0002756MyD88-independent toll-like receptor signaling pathway378
GO:0034383low-density lipoprotein particle clearance17
GO:0043406positive regulation of MAP kinase activity246
GO:0004045aminoacyl-tRNA hydrolase activity13
GO:0035136forelimb morphogenesis19
GO:0051059NF-kappaB binding325
GO:0014734skeletal muscle hypertrophy11
GO:0000387spliceosomal snRNP assembly227
GO:0043491protein kinase B signaling232
GO:0004839ubiquitin activating enzyme activity14
GO:0006422aspartyl-tRNA aminoacylation11
GO:0042130negative regulation of T cell proliferation130
GO:0034103regulation of tissue remodeling13
GO:0004871signal transducer activity4208
GO:0008137NADH dehydrogenase (ubiquinone) activity136
GO:0008209androgen metabolic process112
GO:2001243negative regulation of intrinsic apoptotic signaling pathway121
GO:0070491repressing transcription factor binding228
GO:0001085RNA polymerase II transcription factor binding233
GO:0002250adaptive immune response128
GO:0006979response to oxidative stress687
GO:0071479cellular response to ionizing radiation123
GO:0001056RNA polymerase III activity316
GO:0002437inflammatory response to antigenic stimulus114
GO:0000400four-way junction DNA binding19
GO:0010468regulation of gene expression268
GO:0030216keratinocyte differentiation247
GO:0032695negative regulation of interleukin-12 production112
GO:0004815aspartate-tRNA ligase activity12
GO:0014056regulation of acetylcholine secretion, neurotransmission12
GO:0045727positive regulation of translation244
GO:0033088negative regulation of immature T cell proliferation in thymus14
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity792
GO:0005681spliceosomal complex383
GO:0043231intracellular membrane-bounded organelle6318
GO:0043254regulation of protein complex assembly18
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay453
GO:0042975peroxisome proliferator activated receptor binding111
GO:0072602interleukin-4 secretion15
GO:0033013tetrapyrrole metabolic process11
GO:0060749mammary gland alveolus development215
GO:0001530lipopolysaccharide binding113
GO:0001501skeletal system development2119
GO:0035690cellular response to drug349
GO:0035666TRIF-dependent toll-like receptor signaling pathway376
GO:0014909smooth muscle cell migration15
GO:0060298positive regulation of sarcomere organization15
GO:0048029monosaccharide binding16
GO:0005862muscle thin filament tropomyosin14
GO:0046826negative regulation of protein export from nucleus27
GO:0033613activating transcription factor binding318
GO:0004364glutathione transferase activity118
GO:0006241CTP biosynthetic process19
GO:0061547glycogen synthase activity, transferring glucose-1-phosphate12
GO:0045600positive regulation of fat cell differentiation232
GO:0070577lysine-acetylated histone binding117
GO:0060001minus-end directed microfilament motor activity11
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptors115
GO:0071897DNA biosynthetic process128
GO:0051403stress-activated MAPK cascade254
GO:0010875positive regulation of cholesterol efflux111
GO:0032755positive regulation of interleukin-6 production236
GO:0004843ubiquitin-specific protease activity164
GO:1902017regulation of cilium assembly224
GO:0042834peptidoglycan binding19
GO:0051823regulation of synapse structural plasticity15
GO:0043497regulation of protein heterodimerization activity16
GO:0050699WW domain binding121
GO:0006357regulation of transcription from RNA polymerase II promoter23264
GO:0004373glycogen (starch) synthase activity12
GO:0005819spindle1112
GO:0045860positive regulation of protein kinase activity145
GO:0015629actin cytoskeleton5177
GO:0019049evasion or tolerance of host defenses by virus12
GO:0009912auditory receptor cell fate commitment13
GO:2000177regulation of neural precursor cell proliferation17
GO:0000244spliceosomal tri-snRNP complex assembly111
GO:0005634nucleus1594559
GO:0014015positive regulation of gliogenesis12
GO:0006417regulation of translation262
GO:0042346positive regulation of NF-kappaB import into nucleus118
GO:0035257nuclear hormone receptor binding119
GO:0060762regulation of branching involved in mammary gland duct morphogenesis26
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling4145
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity112
GO:0070022transforming growth factor beta receptor homodimeric complex14
GO:0002368B cell cytokine production11
GO:0009967positive regulation of signal transduction156
GO:0017158regulation of calcium ion-dependent exocytosis14
GO:0070932histone H3 deacetylation221
GO:0001714endodermal cell fate specification15
GO:0045191regulation of isotype switching14
GO:0046847filopodium assembly119
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity461
GO:0060844arterial endothelial cell fate commitment11
GO:0031674I band118
GO:0005765lysosomal membrane3203
GO:0010466negative regulation of peptidase activity28
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling111
GO:0007091metaphase/anaphase transition of mitotic cell cycle27
GO:0048505regulation of timing of cell differentiation15
GO:0006418tRNA aminoacylation for protein translation342
GO:0033138positive regulation of peptidyl-serine phosphorylation259
GO:0010711negative regulation of collagen catabolic process11
GO:0005730nucleolus661641
GO:0060988lipid tube assembly12
GO:0006935chemotaxis3105
GO:0006874cellular calcium ion homeostasis270
GO:0030057desmosome123
GO:0001055RNA polymerase II activity38
GO:0031274positive regulation of pseudopodium assembly210
GO:0046825regulation of protein export from nucleus27
GO:0007030Golgi organization349
GO:0016922ligand-dependent nuclear receptor binding118
GO:2000774positive regulation of cellular senescence14
GO:0006913nucleocytoplasmic transport127
GO:0060231mesenchymal to epithelial transition17
GO:0097101blood vessel endothelial cell fate specification11
GO:0021912regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification12
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator114
GO:0005097Rab GTPase activator activity134
GO:0000338protein deneddylation13
GO:0030137COPI-coated vesicle14
GO:0019901protein kinase binding18317
GO:0006541glutamine metabolic process217
GO:0009791post-embryonic development373
GO:0005911cell-cell junction2136
GO:0003823antigen binding222
GO:0000209protein polyubiquitination3116
GO:0030098lymphocyte differentiation14
GO:0050718positive regulation of interleukin-1 beta secretion118
GO:0042974retinoic acid receptor binding111
GO:0035026leading edge cell differentiation12
GO:0060632regulation of microtubule-based movement13
GO:0038027apolipoprotein A-I-mediated signaling pathway14
GO:0035726common myeloid progenitor cell proliferation13
GO:0035414negative regulation of catenin import into nucleus19
GO:0042176regulation of protein catabolic process216
GO:0006336DNA replication-independent nucleosome assembly216
GO:0043011myeloid dendritic cell differentiation215
GO:0070914UV-damage excision repair17
GO:0061647histone H3-K9 modification113
GO:0005788endoplasmic reticulum lumen5145
GO:0048386positive regulation of retinoic acid receptor signaling pathway15
GO:0009817defense response to fungus, incompatible interaction11
GO:0071243cellular response to arsenic-containing substance17
GO:0016567protein ubiquitination4295
GO:0045785positive regulation of cell adhesion240
GO:0046982protein heterodimerization activity8380
GO:0006450regulation of translational fidelity29
GO:0048268clathrin coat assembly213
GO:0003214cardiac left ventricle morphogenesis19
GO:0007186G-protein coupled receptor signaling pathway1289
GO:0036089cleavage furrow formation26
GO:0016363nuclear matrix691
GO:0042169SH2 domain binding230
GO:0035098ESC/E(Z) complex315
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic process12
GO:0060706cell differentiation involved in embryonic placenta development16
GO:0031647regulation of protein stability430
GO:0008175tRNA methyltransferase activity12
GO:0001657ureteric bud development238
GO:0005685U1 snRNP114
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity659
GO:0032964collagen biosynthetic process15
GO:0071346cellular response to interferon-gamma123
GO:0070102interleukin-6-mediated signaling pathway17
GO:0071850mitotic cell cycle arrest110
GO:0003923GPI-anchor transamidase activity15
GO:0043209myelin sheath116
GO:0005846nuclear cap binding complex12
GO:0031639plasminogen activation16
GO:0001106RNA polymerase II transcription corepressor activity221
GO:0006413translational initiation7131
GO:0030198extracellular matrix organization6283
GO:0034612response to tumor necrosis factor227
GO:0019731antibacterial humoral response116
GO:0048024regulation of mRNA splicing, via spliceosome16
GO:2000323negative regulation of glucocorticoid receptor signaling pathway16
GO:0042393histone binding169
GO:2000643positive regulation of early endosome to late endosome transport14
GO:0005759mitochondrial matrix4228
GO:0001739sex chromatin17
GO:0002161aminoacyl-tRNA editing activity27
GO:0010226response to lithium ion210
GO:0033077T cell differentiation in thymus133
GO:0051098regulation of binding15
GO:0012506vesicle membrane117
GO:1901203positive regulation of extracellular matrix assembly12
GO:0004707MAP kinase activity111
GO:0007517muscle organ development483
GO:0043996histone acetyltransferase activity (H4-K8 specific)59
GO:0034402recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex11
GO:0006325chromatin organization12118
GO:0046332SMAD binding240
GO:0005198structural molecule activity3150
GO:0033630positive regulation of cell adhesion mediated by integrin111
GO:0042026protein refolding115
GO:0019427acetyl-CoA biosynthetic process from acetate12
GO:0004416hydroxyacylglutathione hydrolase activity12
GO:0034185apolipoprotein binding114
GO:0016604nuclear body331
GO:0060048cardiac muscle contraction139
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway11
GO:0020037heme binding193
GO:0031510SUMO activating enzyme complex12
GO:0008289lipid binding1106
GO:0042133neurotransmitter metabolic process13
GO:0034641cellular nitrogen compound metabolic process2171
GO:0009405pathogenesis12
GO:0010390histone monoubiquitination111
GO:0032024positive regulation of insulin secretion333
GO:0006284base-excision repair337
GO:0000139Golgi membrane7361
GO:0006921cellular component disassembly involved in execution phase of apoptosis247
GO:0030665clathrin-coated vesicle membrane313
GO:0005923tight junction286
GO:0008270zinc ion binding27997
GO:0010656negative regulation of muscle cell apoptotic process16
GO:1901687glutathione derivative biosynthetic process120
GO:0002710negative regulation of T cell mediated immunity11
GO:0060716labyrinthine layer blood vessel development118
GO:0007626locomotory behavior271
GO:0045657positive regulation of monocyte differentiation14
GO:0006165nucleoside diphosphate phosphorylation113
GO:0007420brain development2167
GO:0008354germ cell migration111
GO:0033235positive regulation of protein sumoylation111
GO:0005179hormone activity179
GO:0043923positive regulation by host of viral transcription111
GO:0060766negative regulation of androgen receptor signaling pathway313
GO:0090400stress-induced premature senescence13
GO:0031965nuclear membrane10168
GO:0001755neural crest cell migration128
GO:0004129cytochrome-c oxidase activity120
GO:0019003GDP binding147
GO:0048709oligodendrocyte differentiation223
GO:0005622intracellular6207
GO:0035413positive regulation of catenin import into nucleus210
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway111
GO:0006364rRNA processing394
GO:0031369translation initiation factor binding215
GO:0006788heme oxidation22
GO:0030325adrenal gland development121
GO:0007219Notch signaling pathway5120
GO:0030574collagen catabolic process267
GO:0007399nervous system development6231
GO:0046972histone acetyltransferase activity (H4-K16 specific)59
GO:0005524ATP binding311298
GO:2000110negative regulation of macrophage apoptotic process14
GO:0016049cell growth349
GO:0044281small molecule metabolic process201211
GO:0033256I-kappaB/NF-kappaB complex13
GO:0008333endosome to lysosome transport229
GO:0003157endocardium development13
GO:0007498mesoderm development126
GO:0035985senescence-associated heterochromatin focus13
GO:0014051gamma-aminobutyric acid secretion24
GO:0010508positive regulation of autophagy222
GO:0045780positive regulation of bone resorption111
GO:0046716muscle cell cellular homeostasis116
GO:0006228UTP biosynthetic process19
GO:0019213deacetylase activity16
GO:0051899membrane depolarization219
GO:0014047glutamate secretion118
GO:0043687post-translational protein modification5162
GO:0030658transport vesicle membrane132
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors134
GO:0034976response to endoplasmic reticulum stress251
GO:0030054cell junction5336
GO:0032355response to estradiol371
GO:0003682chromatin binding19327
GO:0045597positive regulation of cell differentiation127
GO:0032731positive regulation of interleukin-1 beta production17
GO:0001541ovarian follicle development237
GO:0007409axonogenesis265
GO:0014737positive regulation of muscle atrophy12
GO:0031901early endosome membrane175
GO:0001933negative regulation of protein phosphorylation236
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding553
GO:0048167regulation of synaptic plasticity230
GO:0005544calcium-dependent phospholipid binding130
GO:0003714transcription corepressor activity11178
GO:0097242beta-amyloid clearance11
GO:0042438melanin biosynthetic process17
GO:0042301phosphate ion binding110
GO:0019542propionate biosynthetic process12
GO:0030162regulation of proteolysis228
GO:0004352glutamate dehydrogenase (NAD+) activity12
GO:0051276chromosome organization216
GO:0010976positive regulation of neuron projection development158
GO:0043409negative regulation of MAPK cascade213
GO:0000150recombinase activity11
GO:0007605sensory perception of sound2104
GO:0002230positive regulation of defense response to virus by host115
GO:0006449regulation of translational termination15
GO:0008201heparin binding1122
GO:0008543fibroblast growth factor receptor signaling pathway1156
GO:0048871multicellular organismal homeostasis13
GO:0002732positive regulation of dendritic cell cytokine production11
GO:0009055electron carrier activity265
GO:0044208'de novo' AMP biosynthetic process13
GO:0035730S-nitrosoglutathione binding11
GO:0007266Rho protein signal transduction147
GO:0006749glutathione metabolic process127
GO:0031334positive regulation of protein complex assembly213
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding471
GO:0072092ureteric bud invasion12
GO:0003130BMP signaling pathway involved in heart induction13
GO:0035137hindlimb morphogenesis18
GO:0005536glucose binding18
GO:2000363positive regulation of prostaglandin-E synthase activity11
GO:0032701negative regulation of interleukin-18 production11
GO:0007339binding of sperm to zona pellucida225
GO:0033269internode region of axon14
GO:0000166nucleotide binding13259
GO:0003139secondary heart field specification17
GO:0018108peptidyl-tyrosine phosphorylation4132
GO:0048671negative regulation of collateral sprouting15
GO:0001921positive regulation of receptor recycling19
GO:0004715non-membrane spanning protein tyrosine kinase activity342
GO:0000785chromatin673
GO:0048854brain morphogenesis215
GO:0042800histone methyltransferase activity (H3-K4 specific)313
GO:0006356regulation of transcription from RNA polymerase I promoter16
GO:0048813dendrite morphogenesis230
GO:0002830positive regulation of type 2 immune response15
GO:0060389pathway-restricted SMAD protein phosphorylation112
GO:0045814negative regulation of gene expression, epigenetic27
GO:1900246positive regulation of RIG-I signaling pathway14
GO:0043522leucine zipper domain binding18
GO:0008013beta-catenin binding960
GO:0007159leukocyte cell-cell adhesion127
GO:0002944cyclin K-CDK12 complex12
GO:0031410cytoplasmic vesicle4103
GO:0048568embryonic organ development114
GO:0005801cis-Golgi network133
GO:0051918negative regulation of fibrinolysis110
GO:0045471response to ethanol386
GO:0006826iron ion transport19
GO:0000242pericentriolar material114
GO:0030851granulocyte differentiation19
GO:0036464cytoplasmic ribonucleoprotein granule222
GO:1903077negative regulation of protein localization to plasma membrane14
GO:0016327apicolateral plasma membrane110
GO:0006730one-carbon metabolic process123
GO:0050871positive regulation of B cell activation14
GO:0044130negative regulation of growth of symbiont in host117
GO:0006508proteolysis6378
GO:0000082G1/S transition of mitotic cell cycle3149
GO:0016866intramolecular transferase activity11
GO:2000326negative regulation of ligand-dependent nuclear receptor transcription coactivator activity11
GO:0032074negative regulation of nuclease activity11
GO:0048791calcium ion-dependent exocytosis of neurotransmitter14
GO:0007183SMAD protein complex assembly18
GO:0045948positive regulation of translational initiation112
GO:0003365establishment of cell polarity involved in ameboidal cell migration12
GO:0009798axis specification12
GO:0045162clustering of voltage-gated sodium channels17
GO:0051131chaperone-mediated protein complex assembly113
GO:0072372primary cilium126
GO:0006888ER to Golgi vesicle-mediated transport153
GO:0070461SAGA-type complex25
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway235
GO:0008083growth factor activity3141
GO:0032680regulation of tumor necrosis factor production14
GO:0042562hormone binding116
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process344
GO:0050796regulation of insulin secretion181
GO:0014704intercalated disc136
GO:0010564regulation of cell cycle process16
GO:0019863IgE binding15
GO:0009913epidermal cell differentiation18
GO:0050847progesterone receptor signaling pathway26
GO:0001525angiogenesis7191
GO:0030136clathrin-coated vesicle542
GO:0006091generation of precursor metabolites and energy150
GO:0008544epidermis development169
GO:0031333negative regulation of protein complex assembly114
GO:0002367cytokine production involved in immune response11
GO:0043533inositol 1,3,4,5 tetrakisphosphate binding13
GO:0003677DNA binding491218
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process120
GO:0031593polyubiquitin binding122
GO:0071670smooth muscle cell chemotaxis12
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process25
GO:0042866pyruvate biosynthetic process14
GO:0051353positive regulation of oxidoreductase activity17
GO:0010506regulation of autophagy223
GO:0017124SH3 domain binding1113
GO:2001234negative regulation of apoptotic signaling pathway116
GO:0006810transport2242
GO:0004872receptor activity8189
GO:0071638negative regulation of monocyte chemotactic protein-1 production12
GO:0060687regulation of branching involved in prostate gland morphogenesis17
GO:0006402mRNA catabolic process112
GO:0051149positive regulation of muscle cell differentiation427
GO:0016239positive regulation of macroautophagy112
GO:0045670regulation of osteoclast differentiation28
GO:0048010vascular endothelial growth factor receptor signaling pathway120
GO:0090305nucleic acid phosphodiester bond hydrolysis353
GO:0005682U5 snRNP16
GO:0000045autophagic vacuole assembly226
GO:0071392cellular response to estradiol stimulus218
GO:0016310phosphorylation290
GO:0021979hypothalamus cell differentiation12
GO:0051028mRNA transport452
GO:0051901positive regulation of mitochondrial depolarization16
GO:0004859phospholipase inhibitor activity16
GO:0022408negative regulation of cell-cell adhesion111
GO:0001756somitogenesis133
GO:0032467positive regulation of cytokinesis227
GO:0009653anatomical structure morphogenesis283
GO:0090241negative regulation of histone H4 acetylation22
GO:0004221ubiquitin thiolesterase activity136
GO:0032602chemokine production12
GO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation19
GO:0048015phosphatidylinositol-mediated signaling2114
GO:0042789mRNA transcription from RNA polymerase II promoter213
GO:0071933Arp2/3 complex binding15
GO:0042733embryonic digit morphogenesis247
GO:0048546digestive tract morphogenesis114
GO:1902510regulation of apoptotic DNA fragmentation15
GO:0002376immune system process332
GO:0060021palate development172
GO:0031463Cul3-RING ubiquitin ligase complex123
GO:0006974cellular response to DNA damage stimulus7151
GO:0043843ADP-specific glucokinase activity11
GO:0043484regulation of RNA splicing122
GO:0008545JUN kinase kinase activity13
GO:0030195negative regulation of blood coagulation112
GO:0070325lipoprotein particle receptor binding13
GO:0035861site of double-strand break118
GO:0048387negative regulation of retinoic acid receptor signaling pathway28
GO:0035419activation of MAPK activity involved in innate immune response11
GO:0031100organ regeneration150
GO:0001568blood vessel development235
GO:0070306lens fiber cell differentiation111
GO:0008180COP9 signalosome734
GO:0045668negative regulation of osteoblast differentiation136
GO:0006796phosphate-containing compound metabolic process117
GO:0001520outer dense fiber16
GO:0007165signal transduction13907
GO:0045930negative regulation of mitotic cell cycle120
GO:0042482positive regulation of odontogenesis15
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling251
GO:0005669transcription factor TFIID complex422
GO:0046777protein autophosphorylation4158
GO:0032873negative regulation of stress-activated MAPK cascade26
GO:0060913cardiac cell fate determination13
GO:0000151ubiquitin ligase complex163
GO:0051726regulation of cell cycle597
GO:0006629lipid metabolic process190
GO:0032943mononuclear cell proliferation12
GO:0001968fibronectin binding125
GO:0033093Weibel-Palade body14
GO:0003016respiratory system process18
GO:0060126somatotropin secreting cell differentiation13
GO:0005901caveola162
GO:0016591DNA-directed RNA polymerase II, holoenzyme29
GO:0050853B cell receptor signaling pathway229
GO:0016202regulation of striated muscle tissue development15
GO:0006954inflammatory response6277
GO:0004518nuclease activity110
GO:0006952defense response247
GO:0030176integral component of endoplasmic reticulum membrane153
GO:0008134transcription factor binding18242
GO:0005089Rho guanyl-nucleotide exchange factor activity159
GO:0016571histone methylation215
GO:0005783endoplasmic reticulum13556
GO:0060337type I interferon signaling pathway258
GO:0019413acetate biosynthetic process12
GO:0071944cell periphery123
GO:0004716receptor signaling protein tyrosine kinase activity19
GO:0016274protein-arginine N-methyltransferase activity14
GO:0019058viral life cycle1115
GO:0043065positive regulation of apoptotic process7268
GO:0045087innate immune response15596
GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator212
GO:0009612response to mechanical stimulus150
GO:0070933histone H4 deacetylation117
GO:0071665gamma-catenin-TCF7L2 complex11
GO:0016032viral process26534
GO:0001666response to hypoxia7149
GO:0008022protein C-terminus binding8161
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress123
GO:0035063nuclear speck organization11
GO:0006367transcription initiation from RNA polymerase II promoter22184
GO:0002227innate immune response in mucosa216
GO:0045120pronucleus211
GO:0019242methylglyoxal biosynthetic process11
GO:0050872white fat cell differentiation110
GO:0032009early phagosome14
GO:0035556intracellular signal transduction9303
GO:0000976transcription regulatory region sequence-specific DNA binding326
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane127
GO:0001934positive regulation of protein phosphorylation5104
GO:0043366beta selection12
GO:0043085positive regulation of catalytic activity261
GO:0002039p53 binding455
GO:0021942radial glia guided migration of Purkinje cell13
GO:0006366transcription from RNA polymerase II promoter30419
GO:0043401steroid hormone mediated signaling pathway151
GO:0044089positive regulation of cellular component biogenesis11
GO:0032270positive regulation of cellular protein metabolic process114
GO:0035459cargo loading into vesicle14
GO:0031116positive regulation of microtubule polymerization111
GO:0034644cellular response to UV130
GO:0042474middle ear morphogenesis121
GO:0008307structural constituent of muscle241
GO:0002320lymphoid progenitor cell differentiation16
GO:0010832negative regulation of myotube differentiation19
GO:0042826histone deacetylase binding472
GO:0043995histone acetyltransferase activity (H4-K5 specific)59
GO:0004623phospholipase A2 activity111
GO:0010742macrophage derived foam cell differentiation11
GO:0031080nuclear pore outer ring210
GO:0090045positive regulation of deacetylase activity13
GO:0016149translation release factor activity, codon specific13
GO:0017187peptidyl-glutamic acid carboxylation211
GO:0032928regulation of superoxide anion generation11
GO:0000502proteasome complex358
GO:0000302response to reactive oxygen species19
GO:0000122negative regulation of transcription from RNA polymerase II promoter37570
GO:0090398cellular senescence118
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation325
GO:0071608macrophage inflammatory protein-1 alpha production11
GO:0065004protein-DNA complex assembly15
GO:0007413axonal fasciculation113
GO:0043525positive regulation of neuron apoptotic process446
GO:0030667secretory granule membrane212
GO:0050900leukocyte migration2110
GO:0005758mitochondrial intermembrane space156
GO:0051090regulation of sequence-specific DNA binding transcription factor activity320
GO:0032526response to retinoic acid146
GO:0032869cellular response to insulin stimulus163
GO:0006464cellular protein modification process484
GO:2001244positive regulation of intrinsic apoptotic signaling pathway133
GO:0043537negative regulation of blood vessel endothelial cell migration112
GO:0016150translation release factor activity, codon nonspecific11
GO:0002283neutrophil activation involved in immune response13
GO:0006283transcription-coupled nucleotide-excision repair446
GO:0042127regulation of cell proliferation4109
GO:0045872positive regulation of rhodopsin gene expression12
GO:0017148negative regulation of translation240
GO:0071546pi-body15
GO:0071902positive regulation of protein serine/threonine kinase activity226
GO:0042101T cell receptor complex113
GO:0044822poly(A) RNA binding501056
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity743
GO:0010628positive regulation of gene expression7146
GO:0051213dioxygenase activity113
GO:0001974blood vessel remodeling132
GO:0035249synaptic transmission, glutamatergic332
GO:0008380RNA splicing22228
GO:0006983ER overload response19
GO:0045787positive regulation of cell cycle222
GO:0008143poly(A) binding212
GO:0003723RNA binding18342
GO:0005741mitochondrial outer membrane1105
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription216
GO:0009595detection of biotic stimulus13
GO:0072487MSL complex14
GO:0043982histone H4-K8 acetylation515
GO:2001237negative regulation of extrinsic apoptotic signaling pathway235
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors123
GO:0051835positive regulation of synapse structural plasticity14
GO:0004535poly(A)-specific ribonuclease activity211
GO:0071168protein localization to chromatin15
GO:0033160positive regulation of protein import into nucleus, translocation311
GO:0001945lymph vessel development16
GO:0061024membrane organization4145
GO:0051280negative regulation of release of sequestered calcium ion into cytosol14
GO:0048661positive regulation of smooth muscle cell proliferation149
GO:0035024negative regulation of Rho protein signal transduction111
GO:0004602glutathione peroxidase activity113
GO:0032715negative regulation of interleukin-6 production120
GO:0014835myoblast differentiation involved in skeletal muscle regeneration11
GO:2000036regulation of stem cell maintenance111
GO:0034719SMN-Sm protein complex116
GO:0045687positive regulation of glial cell differentiation12
GO:0072201negative regulation of mesenchymal cell proliferation13
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex16
GO:0050764regulation of phagocytosis16
GO:1901385regulation of voltage-gated calcium channel activity13
GO:0005929cilium277
GO:0005643nuclear pore1157
GO:0034614cellular response to reactive oxygen species214
GO:0075713establishment of integrated proviral latency18
GO:0009794regulation of mitotic cell cycle, embryonic11
GO:0010793regulation of mRNA export from nucleus15
GO:0003674molecular_function1444
GO:0035097histone methyltransferase complex321
GO:0043967histone H4 acetylation127
GO:0006511ubiquitin-dependent protein catabolic process5126
GO:0006636unsaturated fatty acid biosynthetic process14
GO:0043565sequence-specific DNA binding11346
GO:0050830defense response to Gram-positive bacterium345
GO:0032374regulation of cholesterol transport14
GO:0032801receptor catabolic process17
GO:0005098Ran GTPase activator activity11
GO:0007254JNK cascade249
GO:0051271negative regulation of cellular component movement16
GO:0006879cellular iron ion homeostasis351
GO:0048712negative regulation of astrocyte differentiation112
GO:0006376mRNA splice site selection115
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway471
GO:0005838proteasome regulatory particle112
GO:0006352DNA-templated transcription, initiation220
GO:0005515protein binding1986024
GO:0022904respiratory electron transport chain185
GO:0006959humoral immune response347
GO:0051017actin filament bundle assembly123
GO:0000777condensed chromosome kinetochore368
GO:0007411axon guidance5319
GO:0005776autophagic vacuole132
GO:0070734histone H3-K27 methylation14
GO:0006778porphyrin-containing compound metabolic process218
GO:0035912dorsal aorta morphogenesis15
GO:0006936muscle contraction387
GO:0042326negative regulation of phosphorylation121
GO:0070830tight junction assembly128
GO:0043932ossification involved in bone remodeling12
GO:0042765GPI-anchor transamidase complex15
GO:0005811lipid particle147
GO:0051897positive regulation of protein kinase B signaling270
GO:0005487nucleocytoplasmic transporter activity314
GO:0007109cytokinesis, completion of separation13
GO:0008637apoptotic mitochondrial changes221
GO:0070849response to epidermal growth factor15
GO:0019887protein kinase regulator activity14
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway261
GO:0042632cholesterol homeostasis148
GO:0051604protein maturation28
GO:0031424keratinization122
GO:0005085guanyl-nucleotide exchange factor activity571
GO:0005737cytoplasm1243767
GO:0001892embryonic placenta development123
GO:0006914autophagy374
GO:0072560type B pancreatic cell maturation12
GO:0048754branching morphogenesis of an epithelial tube127
GO:0006006glucose metabolic process5118
GO:0042730fibrinolysis318
GO:0007182common-partner SMAD protein phosphorylation15
GO:0070664negative regulation of leukocyte proliferation11
GO:0008199ferric iron binding19
GO:0003151outflow tract morphogenesis138
GO:0090263positive regulation of canonical Wnt signaling pathway348
GO:0005845mRNA cap binding complex111
GO:0016581NuRD complex216
GO:0016055Wnt signaling pathway4138
GO:0030240skeletal muscle thin filament assembly15
GO:0000287magnesium ion binding4164
GO:1901673regulation of spindle assembly involved in mitosis11
GO:0030307positive regulation of cell growth269
GO:0060350endochondral bone morphogenesis11
GO:0004550nucleoside diphosphate kinase activity114
GO:0006754ATP biosynthetic process218
GO:0051010microtubule plus-end binding111
GO:0051683establishment of Golgi localization13
GO:0000165MAPK cascade272
GO:0031532actin cytoskeleton reorganization241
GO:0014889muscle atrophy11
GO:0045722positive regulation of gluconeogenesis113
GO:0014912negative regulation of smooth muscle cell migration111
GO:0042307positive regulation of protein import into nucleus415
GO:0048599oocyte development18
GO:0016925protein sumoylation225
GO:0030049muscle filament sliding338
GO:0002028regulation of sodium ion transport113
GO:0016023cytoplasmic membrane-bounded vesicle8105
GO:0050728negative regulation of inflammatory response356
GO:2000370positive regulation of clathrin-mediated endocytosis13
GO:0016272prefoldin complex19
GO:0002576platelet degranulation282
GO:0006362transcription elongation from RNA polymerase I promoter123
GO:0000145exocyst110
GO:0007080mitotic metaphase plate congression113
GO:0007173epidermal growth factor receptor signaling pathway5189
GO:0042493response to drug6284
GO:0061098positive regulation of protein tyrosine kinase activity121
GO:0043524negative regulation of neuron apoptotic process5117
GO:0050772positive regulation of axonogenesis118
GO:0002246wound healing involved in inflammatory response12
GO:0048298positive regulation of isotype switching to IgA isotypes12
GO:0070588calcium ion transmembrane transport295
GO:0006986response to unfolded protein450
GO:0001547antral ovarian follicle growth12
GO:0008353RNA polymerase II carboxy-terminal domain kinase activity116
GO:0000737DNA catabolic process, endonucleolytic235
GO:0034138toll-like receptor 3 signaling pathway379
GO:0030578PML body organization14
GO:0005666DNA-directed RNA polymerase III complex317
GO:0031953negative regulation of protein autophosphorylation19
GO:0005802trans-Golgi network1110
GO:0031325positive regulation of cellular metabolic process18
GO:0030177positive regulation of Wnt signaling pathway127
GO:0007603phototransduction, visible light178
GO:0034273ATG1/UKL1 signaling complex14
GO:0003340negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis13
GO:0000245spliceosomal complex assembly221
GO:0006383transcription from RNA polymerase III promoter339
GO:0035612AP-2 adaptor complex binding17
GO:0071316cellular response to nicotine18
GO:0007528neuromuscular junction development132
GO:0019046release from viral latency22
GO:0008140cAMP response element binding protein binding18
GO:0008286insulin receptor signaling pathway1142
GO:0048011neurotrophin TRK receptor signaling pathway7269
GO:0048747muscle fiber development112
GO:0010633negative regulation of epithelial cell migration112
GO:0007067mitotic nuclear division6227
GO:0009058biosynthetic process110
GO:0044804nucleophagy14
GO:0000792heterochromatin122
GO:0030968endoplasmic reticulum unfolded protein response279
GO:0035986senescence-associated heterochromatin focus assembly13
GO:0045579positive regulation of B cell differentiation110
GO:0019227neuronal action potential propagation17
GO:0045662negative regulation of myoblast differentiation311
GO:0001764neuron migration193
GO:0010827regulation of glucose transport430
GO:0000407pre-autophagosomal structure213
GO:0002176male germ cell proliferation12
GO:0019395fatty acid oxidation211
GO:0042994cytoplasmic sequestering of transcription factor113
GO:0070937CRD-mediated mRNA stability complex36
GO:0045083negative regulation of interleukin-12 biosynthetic process11
GO:0051279regulation of release of sequestered calcium ion into cytosol18
GO:0005875microtubule associated complex128
GO:0005576extracellular region13942
GO:2000138positive regulation of cell proliferation involved in heart morphogenesis14
GO:0006404RNA import into nucleus11
GO:0030318melanocyte differentiation319
GO:0010942positive regulation of cell death120
GO:0090308regulation of methylation-dependent chromatin silencing11
GO:0008156negative regulation of DNA replication120
GO:0032868response to insulin153
GO:0031435mitogen-activated protein kinase kinase kinase binding121
GO:0045664regulation of neuron differentiation118
GO:0042803protein homodimerization activity19595
GO:0016342catenin complex18
GO:0043087regulation of GTPase activity19
GO:0004527exonuclease activity113
GO:0051082unfolded protein binding793
GO:0005905coated pit650
GO:0003420regulation of growth plate cartilage chondrocyte proliferation12
GO:0031432titin binding114
GO:0009615response to virus1126
GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulin15
GO:0050779RNA destabilization13
GO:0070840dynein complex binding12
GO:0018393internal peptidyl-lysine acetylation14
GO:0060170ciliary membrane122
GO:2000679positive regulation of transcription regulatory region DNA binding19
GO:0007214gamma-aminobutyric acid signaling pathway219
GO:0001054RNA polymerase I activity311
GO:0000932cytoplasmic mRNA processing body454
GO:0030955potassium ion binding17
GO:0001658branching involved in ureteric bud morphogenesis343
GO:0019207kinase regulator activity12
GO:0001502cartilage condensation120
GO:0051101regulation of DNA binding15
GO:0022011myelination in peripheral nervous system112
GO:0035457cellular response to interferon-alpha18
GO:0003700sequence-specific DNA binding transcription factor activity39699
GO:0000904cell morphogenesis involved in differentiation14
GO:0001047core promoter binding545
GO:0032757positive regulation of interleukin-8 production120
GO:0034393positive regulation of smooth muscle cell apoptotic process25
GO:0010863positive regulation of phospholipase C activity18
GO:0051592response to calcium ion155
GO:0004353glutamate dehydrogenase [NAD(P)+] activity12
GO:0016742hydroxymethyl-, formyl- and related transferase activity12
GO:0061003positive regulation of dendritic spine morphogenesis18
GO:0035987endodermal cell differentiation126
GO:0003957NAD(P)+ transhydrogenase (B-specific) activity11
GO:0016050vesicle organization111
GO:0045401positive regulation of interleukin-3 biosynthetic process12
GO:0071226cellular response to molecule of fungal origin11
GO:0004866endopeptidase inhibitor activity329
GO:0003727single-stranded RNA binding228
GO:0002020protease binding674
GO:0048662negative regulation of smooth muscle cell proliferation228
GO:0000187activation of MAPK activity390
GO:2000111positive regulation of macrophage apoptotic process13
GO:0008219cell death228
GO:0043503skeletal muscle fiber adaptation12
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress12
GO:0009986cell surface9402
GO:0042692muscle cell differentiation434
GO:0003713transcription coactivator activity24237
GO:0030279negative regulation of ossification214
GO:0000794condensed nuclear chromosome124
GO:0072554blood vessel lumenization12
GO:0019079viral genome replication212
GO:0019903protein phosphatase binding262
GO:0019043establishment of viral latency12
GO:0007166cell surface receptor signaling pathway4147
GO:0008584male gonad development375
GO:0019216regulation of lipid metabolic process116
GO:0016605PML body388
GO:0070053thrombospondin receptor activity14
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process377
GO:0001103RNA polymerase II repressing transcription factor binding227
GO:0004520endodeoxyribonuclease activity16
GO:0006814sodium ion transport149
GO:0043388positive regulation of DNA binding224
GO:0044295axonal growth cone113
GO:0060045positive regulation of cardiac muscle cell proliferation119
GO:0071224cellular response to peptidoglycan14
GO:0001942hair follicle development235
GO:0035731dinitrosyl-iron complex binding11
GO:0038066p38MAPK cascade11
GO:0032956regulation of actin cytoskeleton organization130
GO:0055072iron ion homeostasis221
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter113
GO:0047394glycerophosphoinositol inositolphosphodiesterase activity11
GO:0015267channel activity17
GO:0051259protein oligomerization239
GO:0030284estrogen receptor activity14
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator130
GO:0055010ventricular cardiac muscle tissue morphogenesis124
GO:0045740positive regulation of DNA replication136
GO:0045296cadherin binding324
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity326
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding229
GO:0030900forebrain development149
GO:0001953negative regulation of cell-matrix adhesion212
GO:0050885neuromuscular process controlling balance240
GO:0061035regulation of cartilage development11
GO:0003747translation release factor activity24
GO:0043297apical junction assembly17
GO:0030331estrogen receptor binding227
GO:0005796Golgi lumen372
GO:0006965positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria12
GO:2000587negative regulation of platelet-derived growth factor receptor-beta signaling pathway12
GO:0071407cellular response to organic cyclic compound338
GO:0045202synapse5136
GO:0016620oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor14
GO:0045165cell fate commitment144
GO:0004402histone acetyltransferase activity643
GO:0030516regulation of axon extension15
GO:0048565digestive tract development226
GO:1900745positive regulation of p38MAPK cascade18
GO:0043473pigmentation120
GO:0031091platelet alpha granule113
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains11
GO:0006887exocytosis264
GO:0090237regulation of arachidonic acid secretion11
GO:0070016armadillo repeat domain binding110
GO:0090090negative regulation of canonical Wnt signaling pathway886
GO:0048541Peyer's patch development19
GO:0010716negative regulation of extracellular matrix disassembly24
GO:0033688regulation of osteoblast proliferation13
GO:0006363termination of RNA polymerase I transcription124
GO:0005925focal adhesion9366
GO:0005114type II transforming growth factor beta receptor binding17
GO:0038052estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity11
GO:0032057negative regulation of translational initiation in response to stress35
GO:0090135actin filament branching12
GO:0042752regulation of circadian rhythm337
GO:0045113regulation of integrin biosynthetic process11
GO:0009954proximal/distal pattern formation121
GO:2001287negative regulation of caveolin-mediated endocytosis11
GO:0010870positive regulation of receptor biosynthetic process17
GO:0042445hormone metabolic process113
GO:0007094mitotic spindle assembly checkpoint331
GO:0016234inclusion body219
GO:0071204histone pre-mRNA 3'end processing complex16
GO:00084083'-5' exonuclease activity116
GO:0006401RNA catabolic process114
GO:0031453positive regulation of heterochromatin assembly11
GO:0043434response to peptide hormone545
GO:0033391chromatoid body111
GO:0031966mitochondrial membrane155
GO:0070534protein K63-linked ubiquitination131
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity474
GO:0043010camera-type eye development134
GO:0090316positive regulation of intracellular protein transport217
GO:0071356cellular response to tumor necrosis factor157
GO:0016874ligase activity4214
GO:0006071glycerol metabolic process19
GO:1990075periciliary membrane compartment11
GO:0071347cellular response to interleukin-1231
GO:0005815microtubule organizing center3109
GO:0009991response to extracellular stimulus14
GO:0051044positive regulation of membrane protein ectodomain proteolysis114
GO:1902600hydrogen ion transmembrane transport243
GO:0043425bHLH transcription factor binding124
GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine17
GO:0097100supercoiled DNA binding11
GO:0045880positive regulation of smoothened signaling pathway123
GO:0055086nucleobase-containing small molecule metabolic process170
GO:0032993protein-DNA complex214
GO:0032321positive regulation of Rho GTPase activity182
GO:1901186positive regulation of ERBB signaling pathway11
GO:0038133ERBB2-ERBB3 signaling pathway11
GO:0030099myeloid cell differentiation220
GO:1990090cellular response to nerve growth factor stimulus115
GO:0031418L-ascorbic acid binding118
GO:0010831positive regulation of myotube differentiation18
GO:0051879Hsp90 protein binding117
GO:0000281mitotic cytokinesis221
GO:0006897endocytosis7106
GO:0000266mitochondrial fission112
GO:0070723response to cholesterol17
GO:2000379positive regulation of reactive oxygen species metabolic process223
GO:0008469histone-arginine N-methyltransferase activity16
GO:0010954positive regulation of protein processing15
GO:0032495response to muramyl dipeptide29
GO:0016779nucleotidyltransferase activity17
GO:0035327transcriptionally active chromatin217
GO:0051287NAD binding232
GO:0048511rhythmic process445
GO:0032370positive regulation of lipid transport11
GO:0050679positive regulation of epithelial cell proliferation254
GO:0030425dendrite6230
GO:0032872regulation of stress-activated MAPK cascade18
GO:0001967suckling behavior114
GO:0002554serotonin secretion by platelet13
GO:0038024cargo receptor activity11
GO:0030858positive regulation of epithelial cell differentiation16
GO:0032091negative regulation of protein binding332
GO:0070555response to interleukin-1230
GO:0002199zona pellucida receptor complex210
GO:0042110T cell activation142
GO:0008021synaptic vesicle273
GO:0006094gluconeogenesis143
GO:0030027lamellipodium7125
GO:0048199vesicle targeting, to, from or within Golgi11
GO:0043005neuron projection3157
GO:0034332adherens junction organization236
GO:0006606protein import into nucleus230
GO:0045177apical part of cell381
GO:0030194positive regulation of blood coagulation110
GO:0003688DNA replication origin binding16
GO:0006396RNA processing559
GO:0006521regulation of cellular amino acid metabolic process150
GO:1900026positive regulation of substrate adhesion-dependent cell spreading323
GO:2000134negative regulation of G1/S transition of mitotic cell cycle120
GO:0016209antioxidant activity214
GO:0035615clathrin adaptor activity18
GO:0007026negative regulation of microtubule depolymerization116
GO:0005975carbohydrate metabolic process8253
GO:0006611protein export from nucleus325
GO:0051106positive regulation of DNA ligation13
GO:0000786nucleosome259
GO:0017075syntaxin-1 binding119
GO:0008135translation factor activity, nucleic acid binding324
GO:0004867serine-type endopeptidase inhibitor activity363
GO:0030122AP-2 adaptor complex110
GO:0006953acute-phase response135
GO:0006429leucyl-tRNA aminoacylation12
GO:0061136regulation of proteasomal protein catabolic process112
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity245
GO:0030235nitric-oxide synthase regulator activity19
GO:0005881cytoplasmic microtubule140
GO:0097157pre-mRNA intronic binding14
GO:0008331high voltage-gated calcium channel activity210
GO:0031990mRNA export from nucleus in response to heat stress22
GO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor15
GO:0010543regulation of platelet activation14
GO:0005109frizzled binding131
GO:0060712spongiotrophoblast layer development17
GO:0015030Cajal body244
GO:0051156glucose 6-phosphate metabolic process17
GO:0023057negative regulation of signaling11
GO:0070979protein K11-linked ubiquitination126
GO:0070934CRD-mediated mRNA stabilization25
GO:0045121membrane raft3156
GO:0030056hemidesmosome19
GO:0042744hydrogen peroxide catabolic process118
GO:0051928positive regulation of calcium ion transport126
GO:0005751mitochondrial respiratory chain complex IV14
GO:00709353'-UTR-mediated mRNA stabilization312
GO:00055451-phosphatidylinositol binding117
GO:0018076N-terminal peptidyl-lysine acetylation13
GO:0006099tricarboxylic acid cycle128
GO:0007416synapse assembly333
GO:0007340acrosome reaction110
GO:0010033response to organic substance127
GO:0086005ventricular cardiac muscle cell action potential116
GO:0001889liver development377
GO:0046185aldehyde catabolic process12
GO:0051920peroxiredoxin activity13
GO:0035964COPI-coated vesicle budding11
GO:0001726ruffle480
GO:0048701embryonic cranial skeleton morphogenesis127
GO:0007268synaptic transmission5332
GO:0006955immune response1288
GO:0070488neutrophil aggregation12
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway223
GO:0032930positive regulation of superoxide anion generation27
GO:0016020membrane461681
GO:0043305negative regulation of mast cell degranulation11
GO:0035259glucocorticoid receptor binding19
GO:0090204protein localization to nuclear pore12
GO:0032059bleb17
GO:0042472inner ear morphogenesis250
GO:0030071regulation of mitotic metaphase/anaphase transition15
GO:0009611response to wounding552
GO:0004347glucose-6-phosphate isomerase activity11
GO:0003954NADH dehydrogenase activity16
GO:0016337single organismal cell-cell adhesion284
GO:0000077DNA damage checkpoint127
GO:0090026positive regulation of monocyte chemotaxis111
GO:0043532angiostatin binding12
GO:0045648positive regulation of erythrocyte differentiation121
GO:0050771negative regulation of axonogenesis120
GO:0010369chromocenter111
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway134
GO:0070087chromo shadow domain binding16
GO:0035642histone methyltransferase activity (H3-R17 specific)11
GO:0034097response to cytokine250
GO:0051568histone H3-K4 methylation317
GO:0004630phospholipase D activity15
GO:0016328lateral plasma membrane346
GO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesis17
GO:0048535lymph node development116
GO:0017166vinculin binding111
GO:0060395SMAD protein signal transduction116
GO:0003161cardiac conduction system development13
GO:0019104DNA N-glycosylase activity14
GO:0009957epidermal cell fate specification11
GO:0016477cell migration4128
GO:0071260cellular response to mechanical stimulus465
GO:0045786negative regulation of cell cycle339
GO:0047485protein N-terminus binding386
GO:0040008regulation of growth250
GO:0032691negative regulation of interleukin-1 beta production16
GO:0032570response to progesterone132
GO:0007292female gamete generation116
GO:0006302double-strand break repair362
GO:0030018Z disc497
GO:1900738positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway11
GO:0070301cellular response to hydrogen peroxide241
GO:0001935endothelial cell proliferation112
GO:0045862positive regulation of proteolysis221
GO:0006468protein phosphorylation10460
GO:0090399replicative senescence110
GO:0005694chromosome270
GO:0033280response to vitamin D114
GO:0043277apoptotic cell clearance113
GO:0006886intracellular protein transport4171
GO:0008047enzyme activator activity339
GO:0060041retina development in camera-type eye251
GO:0009952anterior/posterior pattern specification483
GO:0030214hyaluronan catabolic process113
GO:0010629negative regulation of gene expression477
GO:0071320cellular response to cAMP140
GO:0007050cell cycle arrest5124
GO:0017156calcium ion-dependent exocytosis116
GO:0045686negative regulation of glial cell differentiation12
GO:0006937regulation of muscle contraction113
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia126
GO:0042953lipoprotein transport212
GO:0030097hemopoiesis156
GO:0004407histone deacetylase activity216
GO:0042483negative regulation of odontogenesis11
GO:0071107response to parathyroid hormone13
GO:0044297cell body246
GO:0046872metal ion binding291307
GO:0001948glycoprotein binding250
GO:0034660ncRNA metabolic process123
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest164
GO:0032456endocytic recycling115
GO:2000628regulation of miRNA metabolic process12
GO:0045295gamma-catenin binding112
GO:0032481positive regulation of type I interferon production661
GO:0007596blood coagulation11455
GO:0007021tubulin complex assembly14
GO:0043090amino acid import11
GO:0030274LIM domain binding17
GO:0005736DNA-directed RNA polymerase I complex312
GO:0031293membrane protein intracellular domain proteolysis114
GO:0032897negative regulation of viral transcription112
GO:0000189MAPK import into nucleus12
GO:0034446substrate adhesion-dependent cell spreading236
GO:0042802identical protein binding19484
GO:0060718chorionic trophoblast cell differentiation14
GO:0006334nucleosome assembly372
GO:0048545response to steroid hormone113
GO:0071333cellular response to glucose stimulus133
GO:0038127ERBB signaling pathway14
GO:0007155cell adhesion5369
GO:0060173limb development116
GO:0010957negative regulation of vitamin D biosynthetic process14
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity110
GO:0097284hepatocyte apoptotic process19
GO:0032733positive regulation of interleukin-10 production219
GO:0017091AU-rich element binding214
GO:0004743pyruvate kinase activity12
GO:0046641positive regulation of alpha-beta T cell proliferation110
GO:0051771negative regulation of nitric-oxide synthase biosynthetic process14
GO:0055008cardiac muscle tissue morphogenesis112
GO:0045773positive regulation of axon extension118
GO:0097167circadian regulation of translation14
GO:0045425positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process13
GO:0005516calmodulin binding2160
GO:0031012extracellular matrix6154
GO:1903506regulation of nucleic acid-templated transcription118
GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex13
GO:0032269negative regulation of cellular protein metabolic process14
GO:0045669positive regulation of osteoblast differentiation155
GO:0050714positive regulation of protein secretion328
GO:0043130ubiquitin binding245
GO:2000630positive regulation of miRNA metabolic process14
GO:0000086G2/M transition of mitotic cell cycle4136
GO:0097320membrane tubulation110
GO:0010951negative regulation of endopeptidase activity6104
GO:0034970histone H3-R2 methylation12
GO:0007016cytoskeletal anchoring at plasma membrane113
GO:0045292mRNA cis splicing, via spliceosome15
GO:0019509L-methionine biosynthetic process from methylthioadenosine39
GO:0032740positive regulation of interleukin-17 production211
GO:0005684U2-type spliceosomal complex12
GO:0014850response to muscle activity18
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)113
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic226
GO:0048306calcium-dependent protein binding256
GO:0032729positive regulation of interferon-gamma production139
GO:0030330DNA damage response, signal transduction by p53 class mediator114
GO:0005768endosome3169
GO:0051171regulation of nitrogen compound metabolic process11
GO:0001725stress fiber455
GO:0010389regulation of G2/M transition of mitotic cell cycle18
GO:0090190positive regulation of branching involved in ureteric bud morphogenesis117
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent172
GO:0001843neural tube closure274
GO:0005215transporter activity3130
GO:0031065positive regulation of histone deacetylation29
GO:0002523leukocyte migration involved in inflammatory response18
GO:0001824blastocyst development215
GO:0030838positive regulation of actin filament polymerization134
GO:0016407acetyltransferase activity210
GO:0072562blood microparticle3111
GO:0048538thymus development236
GO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathway15
GO:0048741skeletal muscle fiber development116
GO:0005814centriole279
GO:0051496positive regulation of stress fiber assembly438
GO:0006928cellular component movement391
GO:0072073kidney epithelium development11
GO:0007204positive regulation of cytosolic calcium ion concentration2102
GO:0061140lung secretory cell differentiation11
GO:0000723telomere maintenance156
GO:0046966thyroid hormone receptor binding626
GO:0070252actin-mediated cell contraction12
GO:0003136negative regulation of heart induction by canonical Wnt signaling pathway13
GO:0042162telomeric DNA binding111
GO:0034113heterotypic cell-cell adhesion119
GO:0009898cytoplasmic side of plasma membrane241
GO:0000123histone acetyltransferase complex621
GO:0031536positive regulation of exit from mitosis14
GO:0006457protein folding7143
GO:0006085acetyl-CoA biosynthetic process11
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding12165
GO:0003729mRNA binding472
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity219
GO:0017016Ras GTPase binding114
GO:0042475odontogenesis of dentin-containing tooth155
GO:0032461positive regulation of protein oligomerization112
GO:0002062chondrocyte differentiation232
GO:0009314response to radiation127
GO:0006412translation8230
GO:0045596negative regulation of cell differentiation120
GO:0034260negative regulation of GTPase activity210
GO:0043536positive regulation of blood vessel endothelial cell migration317
GO:0002040sprouting angiogenesis223
GO:0005891voltage-gated calcium channel complex224
GO:0006183GTP biosynthetic process18
GO:0004222metalloendopeptidase activity177
GO:0030178negative regulation of Wnt signaling pathway435
GO:0006999nuclear pore organization14
GO:0060527prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis17
GO:0030521androgen receptor signaling pathway541
GO:0030135coated vesicle13
GO:0006633fatty acid biosynthetic process132
GO:2001046positive regulation of integrin-mediated signaling pathway15
GO:0030308negative regulation of cell growth6110
GO:0045214sarcomere organization226
GO:0030030cell projection organization126
GO:0000296spermine transport11
GO:0034605cellular response to heat128
GO:0048554positive regulation of metalloenzyme activity16
GO:0031492nucleosomal DNA binding227
GO:0046645positive regulation of gamma-delta T cell activation11
GO:0034329cell junction assembly368
GO:0005874microtubule7249
GO:0048210Golgi vesicle fusion to target membrane12
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)112
GO:0090330regulation of platelet aggregation14
GO:0060711labyrinthine layer development39
GO:0043015gamma-tubulin binding118
GO:0046578regulation of Ras protein signal transduction17
GO:0035984cellular response to trichostatin A12
GO:0016887ATPase activity1140
GO:0072686mitotic spindle329
GO:0090004positive regulation of establishment of protein localization to plasma membrane122
GO:0022624proteasome accessory complex117
GO:0021895cerebral cortex neuron differentiation19
GO:0021553olfactory nerve development13
GO:0003684damaged DNA binding249
GO:0019827stem cell maintenance747
GO:0016575histone deacetylation321
GO:0008060ARF GTPase activator activity222
GO:0033198response to ATP116
GO:0007043cell-cell junction assembly112
GO:0043330response to exogenous dsRNA124
GO:0042382paraspeckles26
GO:0048593camera-type eye morphogenesis116
GO:0002102podosome116
GO:0034395regulation of transcription from RNA polymerase II promoter in response to iron13
GO:0002281macrophage activation involved in immune response16
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling230
GO:0004252serine-type endopeptidase activity3106
GO:0046827positive regulation of protein export from nucleus113
GO:0060391positive regulation of SMAD protein import into nucleus411
GO:0016235aggresome121
GO:0033558protein deacetylase activity19
GO:0000125PCAF complex16
GO:0051281positive regulation of release of sequestered calcium ion into cytosol124
GO:0031016pancreas development121
GO:0007176regulation of epidermal growth factor-activated receptor activity15
GO:0019048modulation by virus of host morphology or physiology112
GO:0031434mitogen-activated protein kinase kinase binding112
GO:0004672protein kinase activity3177
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway143
GO:0007097nuclear migration16
GO:0006386termination of RNA polymerase III transcription318
GO:0009953dorsal/ventral pattern formation231
GO:0021679cerebellar molecular layer development11
GO:0010719negative regulation of epithelial to mesenchymal transition119
GO:0048146positive regulation of fibroblast proliferation144
GO:0045599negative regulation of fat cell differentiation235
GO:0046970NAD-dependent histone deacetylase activity (H4-K16 specific)112
GO:0005978glycogen biosynthetic process126
GO:0071681cellular response to indole-3-methanol15
GO:0045663positive regulation of myoblast differentiation211
GO:0007422peripheral nervous system development225
GO:0090022regulation of neutrophil chemotaxis13
GO:0051716cellular response to stimulus44
GO:0035329hippo signaling526
GO:0005245voltage-gated calcium channel activity232
GO:0050729positive regulation of inflammatory response248
GO:0042405nuclear inclusion body29
GO:0030496midbody2108
GO:2000078positive regulation of type B pancreatic cell development13
GO:0015631tubulin binding227
GO:0016574histone ubiquitination17
GO:0019228neuronal action potential118
GO:0043086negative regulation of catalytic activity272
GO:0005886plasma membrane492582
GO:0008043intracellular ferritin complex12
GO:0016461unconventional myosin complex17
GO:0000226microtubule cytoskeleton organization252
GO:0043113receptor clustering119
GO:0051591response to cAMP445
GO:0042147retrograde transport, endosome to Golgi141
GO:0071480cellular response to gamma radiation113
GO:0005902microvillus338
GO:0008645hexose transport439
GO:0006306DNA methylation122
GO:0090307spindle assembly involved in mitosis110
GO:0005509calcium ion binding11531
GO:0071338positive regulation of hair follicle cell proliferation12
GO:0002755MyD88-dependent toll-like receptor signaling pathway580
GO:0016324apical plasma membrane1199
GO:0043407negative regulation of MAP kinase activity132
GO:0097190apoptotic signaling pathway3113
GO:0043486histone exchange13
GO:0008889glycerophosphodiester phosphodiesterase activity13
GO:0010936negative regulation of macrophage cytokine production14
GO:0006621protein retention in ER lumen18
GO:0003334keratinocyte development16
GO:0043578nuclear matrix organization11
GO:0030864cortical actin cytoskeleton123
GO:0030140trans-Golgi network transport vesicle112
GO:0035732nitric oxide storage11
GO:0019957C-C chemokine binding15
GO:0032320positive regulation of Ras GTPase activity132
GO:0060390regulation of SMAD protein import into nucleus11
GO:0043620regulation of DNA-templated transcription in response to stress15
GO:0051152positive regulation of smooth muscle cell differentiation14
GO:0045861negative regulation of proteolysis418
GO:00063707-methylguanosine mRNA capping530
GO:0010884positive regulation of lipid storage15
GO:0006403RNA localization12
GO:0071225cellular response to muramyl dipeptide13
GO:0032498detection of muramyl dipeptide11
GO:0007584response to nutrient371
GO:1901189positive regulation of ephrin receptor signaling pathway11
GO:0032312regulation of ARF GTPase activity221
GO:0004864protein phosphatase inhibitor activity124
GO:0016592mediator complex1035
GO:0010965regulation of mitotic sister chromatid separation11
GO:0031398positive regulation of protein ubiquitination152
GO:0007588excretion235
GO:0048664neuron fate determination14
GO:0031093platelet alpha granule lumen248
GO:0006167AMP biosynthetic process14
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process175
GO:0006892post-Golgi vesicle-mediated transport243
GO:0005665DNA-directed RNA polymerase II, core complex416
GO:0003148outflow tract septum morphogenesis114
GO:0006361transcription initiation from RNA polymerase I promoter126
GO:0060065uterus development111
GO:0086069bundle of His cell to Purkinje myocyte communication18
GO:0051216cartilage development155
GO:0051435BH4 domain binding11
GO:0003743translation initiation factor activity749
GO:0005913cell-cell adherens junction329
GO:0001837epithelial to mesenchymal transition233
GO:0000975regulatory region DNA binding29
GO:0071257cellular response to electrical stimulus211
GO:0016746transferase activity, transferring acyl groups113
GO:0042306regulation of protein import into nucleus23
GO:0016580Sin3 complex112
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-proline16
GO:0060744mammary gland branching involved in thelarche26
GO:0035067negative regulation of histone acetylation28
GO:0006915apoptotic process12555
GO:0035091phosphatidylinositol binding161
GO:0048469cell maturation138
GO:0060070canonical Wnt signaling pathway475
GO:0032007negative regulation of TOR signaling120
GO:0048675axon extension221
GO:0009636response to toxic substance165
GO:0007274neuromuscular synaptic transmission117
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding444
GO:1903251multi-ciliated epithelial cell differentiation14
GO:0070688MLL5-L complex18
GO:0035066positive regulation of histone acetylation115
GO:0033503HULC complex14
GO:0006438valyl-tRNA aminoacylation12
GO:0042383sarcolemma171
GO:0050715positive regulation of cytokine secretion122
GO:0002686negative regulation of leukocyte migration15
GO:0016358dendrite development130
GO:0044257cellular protein catabolic process111
GO:0008168methyltransferase activity241
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay210
GO:0004713protein tyrosine kinase activity382
GO:0046326positive regulation of glucose import124
GO:0071565nBAF complex112
GO:0051489regulation of filopodium assembly17
GO:0048642negative regulation of skeletal muscle tissue development18
GO:0071105response to interleukin-1111
GO:0005546phosphatidylinositol-4,5-bisphosphate binding239
GO:0061099negative regulation of protein tyrosine kinase activity17
GO:0035914skeletal muscle cell differentiation241
GO:0048566embryonic digestive tract development114
GO:0071389cellular response to mineralocorticoid stimulus12
GO:0019221cytokine-mediated signaling pathway8221
GO:0045070positive regulation of viral genome replication117
GO:0005635nuclear envelope5113
GO:0042742defense response to bacterium560
GO:0007184SMAD protein import into nucleus17
GO:0001932regulation of protein phosphorylation120
GO:0007602phototransduction117
GO:0043619regulation of transcription from RNA polymerase II promoter in response to oxidative stress15
GO:0046832negative regulation of RNA export from nucleus12
GO:0050920regulation of chemotaxis15
GO:0006987activation of signaling protein activity involved in unfolded protein response261
GO:0006281DNA repair14261
GO:0050852T cell receptor signaling pathway285
GO:0001669acrosomal vesicle249
GO:0019950SMT3-dependent protein catabolic process12
GO:0070026nitric oxide binding11
GO:0033146regulation of intracellular estrogen receptor signaling pathway13
GO:0060134prepulse inhibition111
GO:0038095Fc-epsilon receptor signaling pathway5168
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity110
GO:0070530K63-linked polyubiquitin binding211
GO:0006995cellular response to nitrogen starvation14
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening211
GO:0097371MDM2/MDM4 family protein binding15
GO:0031625ubiquitin protein ligase binding5178
GO:0005850eukaryotic translation initiation factor 2 complex13
GO:0002513tolerance induction to self antigen13
GO:0071603endothelial cell-cell adhesion13
GO:0034696response to prostaglandin F12
GO:0060271cilium morphogenesis337
GO:0060177regulation of angiotensin metabolic process11
GO:0015031protein transport11341
GO:0008285negative regulation of cell proliferation10353
GO:0060313negative regulation of blood vessel remodeling11
GO:0003899DNA-directed RNA polymerase activity325
GO:0004563beta-N-acetylhexosaminidase activity13
GO:0051056regulation of small GTPase mediated signal transduction3115
GO:0007141male meiosis I116
GO:0034340response to type I interferon14
GO:0004046aminoacylase activity14
GO:0045351type I interferon biosynthetic process15
GO:0048384retinoic acid receptor signaling pathway115
GO:0048266behavioral response to pain114
GO:0043234protein complex11295
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation275
GO:0006338chromatin remodeling366
GO:0097191extrinsic apoptotic signaling pathway138
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription6147
GO:0070314G1 to G0 transition13
GO:0042167heme catabolic process26
GO:0043116negative regulation of vascular permeability110
GO:0005095GTPase inhibitor activity113
GO:0034045pre-autophagosomal structure membrane212
GO:0090136epithelial cell-cell adhesion19
GO:0031529ruffle organization115
GO:0007565female pregnancy278
GO:0001046core promoter sequence-specific DNA binding126
GO:0043120tumor necrosis factor binding12
GO:0007093mitotic cell cycle checkpoint131
GO:0030132clathrin coat of coated pit17
GO:0030139endocytic vesicle244
GO:0006898receptor-mediated endocytosis384
GO:0007010cytoskeleton organization491
GO:0051209release of sequestered calcium ion into cytosol126
GO:0051525NFAT protein binding25
GO:0050663cytokine secretion17
GO:0008652cellular amino acid biosynthetic process117
GO:0030742GTP-dependent protein binding117
GO:0031129inductive cell-cell signaling11
GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process354
GO:0030334regulation of cell migration550
GO:0042954lipoprotein transporter activity11
GO:1902177positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway13
GO:1902262apoptotic process involved in patterning of blood vessels16
GO:0007017microtubule-based process227
GO:0030165PDZ domain binding194
GO:0043495protein anchor19
GO:0071514genetic imprinting16
GO:0055085transmembrane transport8435
GO:0030182neuron differentiation176
GO:0003382epithelial cell morphogenesis19
GO:0061029eyelid development in camera-type eye210
GO:0002862negative regulation of inflammatory response to antigenic stimulus16
GO:0045080positive regulation of chemokine biosynthetic process19
GO:0031442positive regulation of mRNA 3'-end processing15
GO:0046849bone remodeling115
GO:0033600negative regulation of mammary gland epithelial cell proliferation15
GO:0046330positive regulation of JNK cascade255
GO:0051444negative regulation of ubiquitin-protein transferase activity17
GO:0051233spindle midzone215
GO:0005762mitochondrial large ribosomal subunit114
GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors115
GO:0017137Rab GTPase binding176
GO:1901741positive regulation of myoblast fusion15
GO:0000186activation of MAPKK activity254
GO:0001227RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription219
GO:0071300cellular response to retinoic acid155
GO:0048514blood vessel morphogenesis117
GO:0045429positive regulation of nitric oxide biosynthetic process135
GO:0007167enzyme linked receptor protein signaling pathway19
GO:0007468regulation of rhodopsin gene expression12
GO:0005770late endosome293
GO:0000389mRNA 3'-splice site recognition25
GO:0005092GDP-dissociation inhibitor activity17
GO:0005832chaperonin-containing T-complex29
GO:0006120mitochondrial electron transport, NADH to ubiquinone136
GO:0008237metallopeptidase activity152
GO:0006415translational termination287
GO:0001104RNA polymerase II transcription cofactor activity833
GO:0035306positive regulation of dephosphorylation11
GO:0051258protein polymerization227
GO:0006469negative regulation of protein kinase activity465
GO:0034399nuclear periphery512
GO:0045588positive regulation of gamma-delta T cell differentiation15
GO:0050680negative regulation of epithelial cell proliferation251
GO:0010763positive regulation of fibroblast migration18
GO:0005938cell cortex5104
GO:0030877beta-catenin destruction complex210
GO:0008344adult locomotory behavior244
GO:0000060protein import into nucleus, translocation124
GO:0045807positive regulation of endocytosis114
GO:0007172signal complex assembly18
GO:0017053transcriptional repressor complex251
GO:0016579protein deubiquitination142
GO:0031663lipopolysaccharide-mediated signaling pathway229
GO:0045766positive regulation of angiogenesis288
GO:0004869cysteine-type endopeptidase inhibitor activity223
GO:0007599hemostasis29
GO:0003256regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation13
GO:0030317sperm motility133
GO:0005884actin filament344
GO:0042770signal transduction in response to DNA damage111
GO:0031069hair follicle morphogenesis127
GO:0036302atrioventricular canal development15
GO:0006501C-terminal protein lipidation126
GO:1902003regulation of beta-amyloid formation11
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription422
GO:0031175neuron projection development175
GO:0043296apical junction complex19
GO:0060585positive regulation of prostaglandin-endoperoxide synthase activity13
GO:0060024rhythmic synaptic transmission14
GO:0043306positive regulation of mast cell degranulation29
GO:0042473outer ear morphogenesis18
GO:0032025response to cobalt ion15
GO:0045732positive regulation of protein catabolic process150
GO:0005794Golgi apparatus9610
GO:0005248voltage-gated sodium channel activity116
GO:0006750glutathione biosynthetic process110