int-snw-7775

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.988 3.41e-17 6.87e-05 8.50e-04
chia-screen-data-Fav-int-snw-7775 subnetwork

Genes (10)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
EP300 2033 22-2.2743.120415YesYes
[ ZNF232 ] 7775 1-1.4812.9884--
MCRS1 10445 14-2.6603.07963YesYes
YAP1 10413 94-4.2563.53853Yes-
INO80E 283899 10-2.6633.07920Yes-
NFRKB 4798 48-3.1293.10823YesYes
POU5F1 5460 133-5.1483.538179YesYes
YY1 7528 24-2.5723.120114YesYes
HNRNPU 3192 76-2.8693.538139Yes-
DDIT3 1649 60-2.8253.504343YesYes

Interactions (15)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
MCRS1 10445 INO80E 283899 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
YY1 7528 ZNF232 7775 pp -- int.I2D: BioGrid;
int.Ravasi: -
NFRKB 4798 INO80E 283899 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid
NFRKB 4798 MCRS1 10445 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid
EP300 2033 YY1 7528 pp -- int.I2D: BioGrid, BCI, HPRD;
int.Transfac: -;
int.Ravasi: -;
int.HPRD: in vivo;
int.DIP: MI:0218(physical interaction)
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
NFRKB 4798 YY1 7528 pp -- int.I2D: BioGrid
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
DDIT3 1649 EP300 2033 pp -- int.Intact: MI:0915(physical association)
YY1 7528 INO80E 283899 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid
EP300 2033 HNRNPU 3192 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vitro, in vivo
NFRKB 4798 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
EP300 2033 YAP1 10413 pp -- int.I2D: BioGrid
YY1 7528 MCRS1 10445 pp -- int.I2D: BioGrid

Related GO terms (212)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0031011Ino80 complex1.16e-101.68e-068.6874614
GO:0006355regulation of transcription, DNA-templated2.02e-082.91e-043.533843997
GO:0003677DNA binding2.88e-064.15e-023.0517491218
GO:0044212transcription regulatory region DNA binding3.53e-065.09e-025.102417168
GO:0005634nucleus9.89e-061.43e-011.662101594559
GO:0006310DNA recombination1.03e-051.48e-016.0573765
GO:0005654nucleoplasm2.84e-054.09e-013.0006641082
GO:0042789mRNA transcription from RNA polymerase II promoter3.36e-054.85e-017.7942213
GO:0003700sequence-specific DNA binding transcription factor activity5.42e-057.82e-013.367539699
GO:0000123histone acetyltransferase complex9.02e-051.00e+007.1022621
GO:0006974cellular response to DNA damage stimulus1.28e-041.00e+004.84137151
GO:0005667transcription factor complex1.98e-041.00e+004.628317175
GO:0003714transcription corepressor activity2.08e-041.00e+004.603311178
GO:0003713transcription coactivator activity4.83e-041.00e+004.190324237
GO:0008134transcription factor binding5.13e-041.00e+004.160318242
GO:0006281DNA repair6.40e-041.00e+004.051314261
GO:0060795cell fate commitment involved in formation of primary germ layer6.93e-041.00e+0010.494111
GO:0060177regulation of angiotensin metabolic process6.93e-041.00e+0010.494111
GO:2000016negative regulation of determination of dorsal identity6.93e-041.00e+0010.494111
GO:1901985positive regulation of protein acetylation6.93e-041.00e+0010.494111
GO:0043969histone H2B acetylation6.93e-041.00e+0010.494111
GO:2000629negative regulation of miRNA metabolic process6.93e-041.00e+0010.494111
GO:0090308regulation of methylation-dependent chromatin silencing6.93e-041.00e+0010.494111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway6.93e-041.00e+0010.494111
GO:0060965negative regulation of gene silencing by miRNA6.93e-041.00e+0010.494111
GO:0034696response to prostaglandin F1.39e-031.00e+009.494112
GO:0060242contact inhibition1.39e-031.00e+009.494112
GO:0014737positive regulation of muscle atrophy1.39e-031.00e+009.494112
GO:0006403RNA localization1.39e-031.00e+009.494112
GO:0009786regulation of asymmetric cell division1.39e-031.00e+009.494112
GO:0090043regulation of tubulin deacetylation1.39e-031.00e+009.494122
GO:0035984cellular response to trichostatin A1.39e-031.00e+009.494112
GO:0071389cellular response to mineralocorticoid stimulus1.39e-031.00e+009.494112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.39e-031.00e+009.494112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.39e-031.00e+009.494112
GO:0006351transcription, DNA-templated1.65e-031.00e+002.3185571446
GO:0018076N-terminal peptidyl-lysine acetylation2.08e-031.00e+008.909113
GO:0060913cardiac cell fate determination2.08e-031.00e+008.909113
GO:0003130BMP signaling pathway involved in heart induction2.08e-031.00e+008.909113
GO:0010560positive regulation of glycoprotein biosynthetic process2.08e-031.00e+008.909113
GO:0005515protein binding2.41e-031.00e+001.10891986024
GO:0097157pre-mRNA intronic binding2.77e-031.00e+008.494114
GO:0018393internal peptidyl-lysine acetylation2.77e-031.00e+008.494114
GO:0006325chromatin organization2.86e-031.00e+004.612212118
GO:0001714endodermal cell fate specification3.46e-031.00e+008.172115
GO:0065004protein-DNA complex assembly3.46e-031.00e+008.172115
GO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor3.46e-031.00e+008.172115
GO:0043620regulation of DNA-templated transcription in response to stress3.46e-031.00e+008.172115
GO:0070934CRD-mediated mRNA stabilization3.46e-031.00e+008.172125
GO:0060298positive regulation of sarcomere organization3.46e-031.00e+008.172115
GO:0032025response to cobalt ion3.46e-031.00e+008.172115
GO:0070937CRD-mediated mRNA stability complex4.15e-031.00e+007.909136
GO:0006475internal protein amino acid acetylation4.84e-031.00e+007.687117
GO:0001955blood vessel maturation5.53e-031.00e+007.494118
GO:0043995histone acetyltransferase activity (H4-K5 specific)6.22e-031.00e+007.324159
GO:0046972histone acetyltransferase activity (H4-K16 specific)6.22e-031.00e+007.324159
GO:0060765regulation of androgen receptor signaling pathway6.22e-031.00e+007.324119
GO:0010225response to UV-C6.22e-031.00e+007.324129
GO:0006983ER overload response6.22e-031.00e+007.324119
GO:0035259glucocorticoid receptor binding6.22e-031.00e+007.324119
GO:0045793positive regulation of cell size6.22e-031.00e+007.324129
GO:0000400four-way junction DNA binding6.22e-031.00e+007.324119
GO:0043996histone acetyltransferase activity (H4-K8 specific)6.22e-031.00e+007.324159
GO:0035413positive regulation of catenin import into nucleus6.91e-031.00e+007.1721210
GO:0016407acetyltransferase activity6.91e-031.00e+007.1721210
GO:0043923positive regulation by host of viral transcription7.60e-031.00e+007.0351111
GO:0033160positive regulation of protein import into nucleus, translocation7.60e-031.00e+007.0351311
GO:0045662negative regulation of myoblast differentiation7.60e-031.00e+007.0351311
GO:0042975peroxisome proliferator activated receptor binding7.60e-031.00e+007.0351111
GO:0060391positive regulation of SMAD protein import into nucleus7.60e-031.00e+007.0351411
GO:0035198miRNA binding8.29e-031.00e+006.9091112
GO:0071480cellular response to gamma radiation8.98e-031.00e+006.7941113
GO:0051019mitogen-activated protein kinase binding8.98e-031.00e+006.7941213
GO:0016746transferase activity, transferring acyl groups8.98e-031.00e+006.7941113
GO:0070542response to fatty acid9.67e-031.00e+006.6871114
GO:0032993protein-DNA complex9.67e-031.00e+006.6871214
GO:0043981histone H4-K5 acetylation1.04e-021.00e+006.5871515
GO:0001824blastocyst development1.04e-021.00e+006.5871215
GO:0043982histone H4-K8 acetylation1.04e-021.00e+006.5871515
GO:1990090cellular response to nerve growth factor stimulus1.04e-021.00e+006.5871115
GO:0051276chromosome organization1.10e-021.00e+006.4941216
GO:0048593camera-type eye morphogenesis1.10e-021.00e+006.4941116
GO:0045773positive regulation of axon extension1.24e-021.00e+006.3241118
GO:0033613activating transcription factor binding1.24e-021.00e+006.3241318
GO:0043984histone H4-K16 acetylation1.31e-021.00e+006.2461519
GO:0035257nuclear hormone receptor binding1.31e-021.00e+006.2461119
GO:0071549cellular response to dexamethasone stimulus1.38e-021.00e+006.1721320
GO:0010942positive regulation of cell death1.38e-021.00e+006.1721120
GO:0032757positive regulation of interleukin-8 production1.38e-021.00e+006.1721120
GO:0032967positive regulation of collagen biosynthetic process1.45e-021.00e+006.1021321
GO:0045862positive regulation of proteolysis1.45e-021.00e+006.1021221
GO:0045944positive regulation of transcription from RNA polymerase II promoter1.47e-021.00e+002.455341789
GO:0003823antigen binding1.52e-021.00e+006.0351222
GO:0036464cytoplasmic ribonucleoprotein granule1.52e-021.00e+006.0351222
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress1.58e-021.00e+005.9711123
GO:0043388positive regulation of DNA binding1.65e-021.00e+005.9091224
GO:0043425bHLH transcription factor binding1.65e-021.00e+005.9091124
GO:0051059NF-kappaB binding1.72e-021.00e+005.8501325
GO:0031519PcG protein complex1.72e-021.00e+005.8501125
GO:0035329hippo signaling1.79e-021.00e+005.7941526
GO:0051209release of sequestered calcium ion into cytosol1.79e-021.00e+005.7941126
GO:0048565digestive tract development1.79e-021.00e+005.7941226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.79e-021.00e+005.7941126
GO:0071339MLL1 complex1.86e-021.00e+005.7391627
GO:0034612response to tumor necrosis factor1.86e-021.00e+005.7391227
GO:0043967histone H4 acetylation1.86e-021.00e+005.7391127
GO:0050714positive regulation of protein secretion1.93e-021.00e+005.6871328
GO:0005730nucleolus1.99e-021.00e+001.8144661641
GO:0034644cellular response to UV2.06e-021.00e+005.5871130
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator2.06e-021.00e+005.5871130
GO:0042594response to starvation2.13e-021.00e+005.5401431
GO:0043491protein kinase B signaling2.20e-021.00e+005.4941232
GO:1903507negative regulation of nucleic acid-templated transcription2.20e-021.00e+005.4941232
GO:0003723RNA binding2.22e-021.00e+003.076218342
GO:0071333cellular response to glucose stimulus2.27e-021.00e+005.4501133
GO:0001756somitogenesis2.27e-021.00e+005.4501133
GO:0043565sequence-specific DNA binding2.27e-021.00e+003.060211346
GO:0001102RNA polymerase II activating transcription factor binding2.47e-021.00e+005.3241136
GO:0032092positive regulation of protein binding2.60e-021.00e+005.2461238
GO:0031490chromatin DNA binding2.60e-021.00e+005.2461238
GO:0050681androgen receptor binding2.60e-021.00e+005.2461138
GO:0035019somatic stem cell maintenance2.74e-021.00e+005.1721640
GO:0007519skeletal muscle tissue development2.74e-021.00e+005.1721240
GO:0046332SMAD binding2.74e-021.00e+005.1721240
GO:0071320cellular response to cAMP2.74e-021.00e+005.1721140
GO:0070301cellular response to hydrogen peroxide2.81e-021.00e+005.1371241
GO:0004402histone acetyltransferase activity2.94e-021.00e+005.0681643
GO:0045727positive regulation of translation3.01e-021.00e+005.0351244
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding3.01e-021.00e+005.0351444
GO:0043966histone H3 acetylation3.08e-021.00e+005.0021545
GO:0001047core promoter binding3.08e-021.00e+005.0021545
GO:0043525positive regulation of neuron apoptotic process3.14e-021.00e+004.9711446
GO:0006366transcription from RNA polymerase II promoter3.25e-021.00e+002.783230419
GO:0035690cellular response to drug3.35e-021.00e+004.8791349
GO:0006986response to unfolded protein3.41e-021.00e+004.8501450
GO:0034976response to endoplasmic reticulum stress3.48e-021.00e+004.8221251
GO:0045454cell redox homeostasis3.48e-021.00e+004.8221151
GO:0009611response to wounding3.55e-021.00e+004.7941552
GO:0007623circadian rhythm3.62e-021.00e+004.7661153
GO:0071300cellular response to retinoic acid3.75e-021.00e+004.7131155
GO:0051592response to calcium ion3.75e-021.00e+004.7131155
GO:0000724double-strand break repair via homologous recombination3.75e-021.00e+004.7131255
GO:0002039p53 binding3.75e-021.00e+004.7131455
GO:0043627response to estrogen3.82e-021.00e+004.6871556
GO:0006396RNA processing4.02e-021.00e+004.6121559
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription4.02e-021.00e+004.6121559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity4.02e-021.00e+004.6121659
GO:0008013beta-catenin binding4.08e-021.00e+004.5871960
GO:0032481positive regulation of type I interferon production4.15e-021.00e+004.5631661
GO:0006987activation of signaling protein activity involved in unfolded protein response4.15e-021.00e+004.5631261
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process4.28e-021.00e+004.5171463
GO:0010468regulation of gene expression4.62e-021.00e+004.4071268
GO:0030324lung development4.88e-021.00e+004.3241172
GO:0000785chromatin4.95e-021.00e+004.3041673
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.02e-021.00e+004.2851474
GO:0002020protease binding5.02e-021.00e+004.2851674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process5.08e-021.00e+004.2651175
GO:0001889liver development5.21e-021.00e+004.2271377
GO:0071013catalytic step 2 spliceosome5.28e-021.00e+004.2091778
GO:0030968endoplasmic reticulum unfolded protein response5.35e-021.00e+004.1901279
GO:0009653anatomical structure morphogenesis5.61e-021.00e+004.1191283
GO:0009952anterior/posterior pattern specification5.61e-021.00e+004.1191483
GO:0006464cellular protein modification process5.68e-021.00e+004.1021484
GO:0000122negative regulation of transcription from RNA polymerase II promoter5.69e-021.00e+002.339237570
GO:0009887organ morphogenesis5.81e-021.00e+004.0681586
GO:0090090negative regulation of canonical Wnt signaling pathway5.81e-021.00e+004.0681886
GO:0045471response to ethanol5.81e-021.00e+004.0681386
GO:0016363nuclear matrix6.14e-021.00e+003.9861691
GO:0001649osteoblast differentiation6.20e-021.00e+003.9711592
GO:0071456cellular response to hypoxia6.20e-021.00e+003.9711392
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity6.20e-021.00e+003.9711792
GO:0005770late endosome6.27e-021.00e+003.9551293
GO:0051726regulation of cell cycle6.53e-021.00e+003.8941597
GO:0001934positive regulation of protein phosphorylation6.98e-021.00e+003.79415104
GO:0030529ribonucleoprotein complex7.50e-021.00e+003.68715112
GO:0010467gene expression7.55e-021.00e+002.108245669
GO:0007219Notch signaling pathway8.02e-021.00e+003.58715120
GO:0006260DNA replication8.08e-021.00e+003.57513121
GO:0007050cell cycle arrest8.27e-021.00e+003.54015124
GO:0000086G2/M transition of mitotic cell cycle9.04e-021.00e+003.40714136
GO:0016055Wnt signaling pathway9.17e-021.00e+003.38614138
GO:0007507heart development9.23e-021.00e+003.37517139
GO:0001666response to hypoxia9.87e-021.00e+003.27517149
GO:0000398mRNA splicing, via spliceosome1.08e-011.00e+003.137115164
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.09e-011.00e+003.128112165
GO:0031625ubiquitin protein ligase binding1.17e-011.00e+003.01815178
GO:0032403protein complex binding1.20e-011.00e+002.97816183
GO:0006367transcription initiation from RNA polymerase II promoter1.21e-011.00e+002.971122184
GO:0008380RNA splicing1.47e-011.00e+002.661122228
GO:0007399nervous system development1.49e-011.00e+002.64216231
GO:0008270zinc ion binding1.49e-011.00e+001.533227997
GO:0044822poly(A) RNA binding1.63e-011.00e+001.4502501056
GO:0007283spermatogenesis1.68e-011.00e+002.46113262
GO:0006357regulation of transcription from RNA polymerase II promoter1.69e-011.00e+002.450123264
GO:0006954inflammatory response1.76e-011.00e+002.38016277
GO:0030154cell differentiation1.90e-011.00e+002.26115301
GO:0003682chromatin binding2.05e-011.00e+002.141119327
GO:0008283cell proliferation2.06e-011.00e+002.137114328
GO:0046982protein heterodimerization activity2.34e-011.00e+001.92418380
GO:0000278mitotic cell cycle2.40e-011.00e+001.883115391
GO:0005829cytosol2.43e-011.00e+000.7943862496
GO:0009986cell surface2.46e-011.00e+001.84319402
GO:0005737cytoplasm2.51e-011.00e+000.61541243767
GO:0045892negative regulation of transcription, DNA-templated2.52e-011.00e+001.804124413
GO:0044267cellular protein metabolic process2.84e-011.00e+001.605120474
GO:0045893positive regulation of transcription, DNA-templated2.86e-011.00e+001.593124478
GO:0016032viral process3.14e-011.00e+001.433126534
GO:0006915apoptotic process3.25e-011.00e+001.378112555
GO:0045087innate immune response3.44e-011.00e+001.275115596
GO:0005524ATP binding6.11e-011.00e+000.1521311298
GO:0046872metal ion binding6.13e-011.00e+000.1421291307
GO:0016020membrane7.11e-011.00e+00-0.2211461681