Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
chia-screen-data-Fav | 2.933 | 1.40e-16 | 1.42e-04 | 1.42e-03 |
Gene Symbol | Entrez Gene ID | Frequency | chia-screen-data-Fav gene score | Best subnetwork score | Degree | Chia-Hits Primary | Chia-Hits Secondary |
---|---|---|---|---|---|---|---|
HCFC1 | 3054 | 40 | -2.925 | 3.449 | 71 | Yes | Yes |
MAP3K4 | 4216 | 2 | -1.940 | 2.976 | 101 | - | - |
MED19 | 219541 | 30 | -2.657 | 3.449 | 115 | Yes | - |
PSMD2 | 5708 | 47 | -4.172 | 3.157 | 386 | Yes | Yes |
LUC7L3 | 51747 | 33 | -3.523 | 3.449 | 18 | Yes | - |
NUP93 | 9688 | 1 | -1.836 | 2.933 | 71 | - | - |
YAP1 | 10413 | 94 | -4.256 | 3.538 | 53 | Yes | - |
NXF1 | 10482 | 10 | -2.426 | 3.538 | 65 | Yes | Yes |
[ RANGAP1 ] | 5905 | 1 | -1.596 | 2.933 | 74 | - | - |
SRSF3 | 6428 | 73 | -2.992 | 3.538 | 54 | Yes | - |
HNRNPU | 3192 | 76 | -2.869 | 3.538 | 139 | Yes | - |
POU5F1 | 5460 | 133 | -5.148 | 3.538 | 179 | Yes | Yes |
MAPK14 | 1432 | 4 | -1.902 | 2.955 | 272 | - | - |
DDIT3 | 1649 | 60 | -2.825 | 3.504 | 343 | Yes | Yes |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
RANGAP1 | 5905 | NXF1 | 10482 | pp | -- | int.Intact: MI:0914(association) |
MAPK14 | 1432 | RANGAP1 | 5905 | pp | -- | int.I2D: BioGrid_Yeast |
MAPK14 | 1432 | DDIT3 | 1649 | pp | -- | int.I2D: BCI, BioGrid, HPRD; int.HPRD: in vitro |
PSMD2 | 5708 | RANGAP1 | 5905 | pp | -- | int.I2D: BioGrid_Yeast |
SRSF3 | 6428 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
MAP3K4 | 4216 | RANGAP1 | 5905 | pp | -- | int.I2D: BioGrid_Yeast |
SRSF3 | 6428 | NXF1 | 10482 | pp | -- | int.I2D: MINT, HPRD; int.Mint: MI:0407(direct interaction), MI:0915(physical association) |
HCFC1 | 3054 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
HNRNPU | 3192 | NXF1 | 10482 | pp | -- | int.Intact: MI:0914(association) |
RANGAP1 | 5905 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
DDIT3 | 1649 | HNRNPU | 3192 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
MAPK14 | 1432 | MAP3K4 | 4216 | pp | -- | int.I2D: BioGrid_Yeast |
POU5F1 | 5460 | SRSF3 | 6428 | pp | -- | int.I2D: BioGrid |
HCFC1 | 3054 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
HNRNPU | 3192 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
LUC7L3 | 51747 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
HNRNPU | 3192 | YAP1 | 10413 | pp | -- | int.I2D: HPRD; int.HPRD: in vitro, in vivo |
RANGAP1 | 5905 | NUP93 | 9688 | pp | -- | int.I2D: BioGrid_Yeast |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0005654 | nucleoplasm | 1.03e-07 | 1.49e-03 | 3.099 | 9 | 64 | 1082 |
GO:0005643 | nuclear pore | 2.07e-05 | 2.98e-01 | 5.761 | 3 | 11 | 57 |
GO:0010467 | gene expression | 2.12e-05 | 3.06e-01 | 3.208 | 6 | 45 | 669 |
GO:0042789 | mRNA transcription from RNA polymerase II promoter | 6.78e-05 | 9.78e-01 | 7.308 | 2 | 2 | 13 |
GO:0044212 | transcription regulatory region DNA binding | 5.14e-04 | 1.00e+00 | 4.201 | 3 | 17 | 168 |
GO:0016607 | nuclear speck | 5.51e-04 | 1.00e+00 | 4.167 | 3 | 12 | 172 |
GO:0006366 | transcription from RNA polymerase II promoter | 5.58e-04 | 1.00e+00 | 3.298 | 4 | 30 | 419 |
GO:0005515 | protein binding | 9.66e-04 | 1.00e+00 | 1.037 | 12 | 198 | 6024 |
GO:0060795 | cell fate commitment involved in formation of primary germ layer | 9.71e-04 | 1.00e+00 | 10.009 | 1 | 1 | 1 |
GO:0038066 | p38MAPK cascade | 9.71e-04 | 1.00e+00 | 10.009 | 1 | 1 | 1 |
GO:2000016 | negative regulation of determination of dorsal identity | 9.71e-04 | 1.00e+00 | 10.009 | 1 | 1 | 1 |
GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration | 9.71e-04 | 1.00e+00 | 10.009 | 1 | 1 | 1 |
GO:0090308 | regulation of methylation-dependent chromatin silencing | 9.71e-04 | 1.00e+00 | 10.009 | 1 | 1 | 1 |
GO:0005098 | Ran GTPase activator activity | 9.71e-04 | 1.00e+00 | 10.009 | 1 | 1 | 1 |
GO:0090081 | regulation of heart induction by regulation of canonical Wnt signaling pathway | 9.71e-04 | 1.00e+00 | 10.009 | 1 | 1 | 1 |
GO:0060965 | negative regulation of gene silencing by miRNA | 9.71e-04 | 1.00e+00 | 10.009 | 1 | 1 | 1 |
GO:0008380 | RNA splicing | 1.25e-03 | 1.00e+00 | 3.761 | 3 | 22 | 228 |
GO:0006406 | mRNA export from nucleus | 1.55e-03 | 1.00e+00 | 5.078 | 2 | 4 | 61 |
GO:0010468 | regulation of gene expression | 1.92e-03 | 1.00e+00 | 4.921 | 2 | 2 | 68 |
GO:0019100 | male germ-line sex determination | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 1 | 2 |
GO:0060242 | contact inhibition | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 1 | 2 |
GO:0019046 | release from viral latency | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 2 | 2 |
GO:0009786 | regulation of asymmetric cell division | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 1 | 2 |
GO:0044324 | regulation of transcription involved in anterior/posterior axis specification | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 1 | 2 |
GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 1 | 2 |
GO:0003729 | mRNA binding | 2.15e-03 | 1.00e+00 | 4.839 | 2 | 4 | 72 |
GO:0044822 | poly(A) RNA binding | 2.39e-03 | 1.00e+00 | 2.286 | 5 | 50 | 1056 |
GO:0090400 | stress-induced premature senescence | 2.91e-03 | 1.00e+00 | 8.424 | 1 | 1 | 3 |
GO:0060913 | cardiac cell fate determination | 2.91e-03 | 1.00e+00 | 8.424 | 1 | 1 | 3 |
GO:0003130 | BMP signaling pathway involved in heart induction | 2.91e-03 | 1.00e+00 | 8.424 | 1 | 1 | 3 |
GO:0090090 | negative regulation of canonical Wnt signaling pathway | 3.05e-03 | 1.00e+00 | 4.582 | 2 | 8 | 86 |
GO:0000922 | spindle pole | 3.12e-03 | 1.00e+00 | 4.566 | 2 | 4 | 87 |
GO:0060718 | chorionic trophoblast cell differentiation | 3.88e-03 | 1.00e+00 | 8.009 | 1 | 1 | 4 |
GO:0070461 | SAGA-type complex | 4.84e-03 | 1.00e+00 | 7.687 | 1 | 2 | 5 |
GO:0001714 | endodermal cell fate specification | 4.84e-03 | 1.00e+00 | 7.687 | 1 | 1 | 5 |
GO:0043620 | regulation of DNA-templated transcription in response to stress | 4.84e-03 | 1.00e+00 | 7.687 | 1 | 1 | 5 |
GO:0070934 | CRD-mediated mRNA stabilization | 4.84e-03 | 1.00e+00 | 7.687 | 1 | 2 | 5 |
GO:0051525 | NFAT protein binding | 4.84e-03 | 1.00e+00 | 7.687 | 1 | 2 | 5 |
GO:1901741 | positive regulation of myoblast fusion | 4.84e-03 | 1.00e+00 | 7.687 | 1 | 1 | 5 |
GO:0005829 | cytosol | 5.09e-03 | 1.00e+00 | 1.531 | 7 | 86 | 2496 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 5.72e-03 | 1.00e+00 | 2.385 | 4 | 41 | 789 |
GO:0000278 | mitotic cell cycle | 5.76e-03 | 1.00e+00 | 2.983 | 3 | 15 | 391 |
GO:0070937 | CRD-mediated mRNA stability complex | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 3 | 6 |
GO:0032853 | positive regulation of Ran GTPase activity | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 6 |
GO:0046826 | negative regulation of protein export from nucleus | 6.78e-03 | 1.00e+00 | 7.201 | 1 | 2 | 7 |
GO:0016973 | poly(A)+ mRNA export from nucleus | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 1 | 8 |
GO:0051292 | nuclear pore complex assembly | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 4 | 8 |
GO:0001955 | blood vessel maturation | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 1 | 8 |
GO:1900745 | positive regulation of p38MAPK cascade | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 1 | 8 |
GO:0070688 | MLL5-L complex | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 1 | 8 |
GO:0043254 | regulation of protein complex assembly | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 1 | 8 |
GO:0010831 | positive regulation of myotube differentiation | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 1 | 8 |
GO:0043995 | histone acetyltransferase activity (H4-K5 specific) | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 5 | 9 |
GO:0046972 | histone acetyltransferase activity (H4-K16 specific) | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 5 | 9 |
GO:0042405 | nuclear inclusion body | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 2 | 9 |
GO:0010225 | response to UV-C | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 2 | 9 |
GO:0048188 | Set1C/COMPASS complex | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 4 | 9 |
GO:0006983 | ER overload response | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 1 | 9 |
GO:0043996 | histone acetyltransferase activity (H4-K8 specific) | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 5 | 9 |
GO:0017056 | structural constituent of nuclear pore | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 2 | 9 |
GO:0032495 | response to muramyl dipeptide | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 2 | 9 |
GO:0006974 | cellular response to DNA damage stimulus | 9.12e-03 | 1.00e+00 | 3.770 | 2 | 7 | 151 |
GO:0035413 | positive regulation of catenin import into nucleus | 9.67e-03 | 1.00e+00 | 6.687 | 1 | 2 | 10 |
GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 1.06e-02 | 1.00e+00 | 6.549 | 1 | 1 | 11 |
GO:0045663 | positive regulation of myoblast differentiation | 1.06e-02 | 1.00e+00 | 6.549 | 1 | 2 | 11 |
GO:0045662 | negative regulation of myoblast differentiation | 1.06e-02 | 1.00e+00 | 6.549 | 1 | 3 | 11 |
GO:0019395 | fatty acid oxidation | 1.06e-02 | 1.00e+00 | 6.549 | 1 | 2 | 11 |
GO:0004707 | MAP kinase activity | 1.06e-02 | 1.00e+00 | 6.549 | 1 | 1 | 11 |
GO:0042770 | signal transduction in response to DNA damage | 1.06e-02 | 1.00e+00 | 6.549 | 1 | 1 | 11 |
GO:0060391 | positive regulation of SMAD protein import into nucleus | 1.06e-02 | 1.00e+00 | 6.549 | 1 | 4 | 11 |
GO:0000398 | mRNA splicing, via spliceosome | 1.07e-02 | 1.00e+00 | 3.651 | 2 | 15 | 164 |
GO:0031965 | nuclear membrane | 1.12e-02 | 1.00e+00 | 3.616 | 2 | 10 | 168 |
GO:0070935 | 3'-UTR-mediated mRNA stabilization | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 3 | 12 |
GO:0034399 | nuclear periphery | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 5 | 12 |
GO:0005838 | proteasome regulatory particle | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 1 | 12 |
GO:0035198 | miRNA binding | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 1 | 12 |
GO:0051146 | striated muscle cell differentiation | 1.16e-02 | 1.00e+00 | 6.424 | 1 | 1 | 12 |
GO:0003714 | transcription corepressor activity | 1.25e-02 | 1.00e+00 | 3.533 | 2 | 11 | 178 |
GO:0071480 | cellular response to gamma radiation | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 1 | 13 |
GO:0004708 | MAP kinase kinase activity | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 1 | 13 |
GO:0030234 | enzyme regulator activity | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 2 | 13 |
GO:0000346 | transcription export complex | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 1 | 13 |
GO:0006355 | regulation of transcription, DNA-templated | 1.30e-02 | 1.00e+00 | 2.047 | 4 | 43 | 997 |
GO:0005685 | U1 snRNP | 1.35e-02 | 1.00e+00 | 6.201 | 1 | 1 | 14 |
GO:0016032 | viral process | 1.35e-02 | 1.00e+00 | 2.533 | 3 | 26 | 534 |
GO:0005487 | nucleocytoplasmic transporter activity | 1.35e-02 | 1.00e+00 | 6.201 | 1 | 3 | 14 |
GO:0043981 | histone H4-K5 acetylation | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 5 | 15 |
GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 3 | 15 |
GO:0042307 | positive regulation of protein import into nucleus | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 4 | 15 |
GO:0001824 | blastocyst development | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 2 | 15 |
GO:0043982 | histone H4-K8 acetylation | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 5 | 15 |
GO:0006376 | mRNA splice site selection | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 1 | 15 |
GO:0043274 | phospholipase binding | 1.54e-02 | 1.00e+00 | 6.009 | 1 | 1 | 16 |
GO:0042176 | regulation of protein catabolic process | 1.54e-02 | 1.00e+00 | 6.009 | 1 | 2 | 16 |
GO:0043536 | positive regulation of blood vessel endothelial cell migration | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 3 | 17 |
GO:0022624 | proteasome accessory complex | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 1 | 17 |
GO:0004709 | MAP kinase kinase kinase activity | 1.73e-02 | 1.00e+00 | 5.839 | 1 | 2 | 18 |
GO:0043984 | histone H4-K16 acetylation | 1.83e-02 | 1.00e+00 | 5.761 | 1 | 5 | 19 |
GO:0051090 | regulation of sequence-specific DNA binding transcription factor activity | 1.92e-02 | 1.00e+00 | 5.687 | 1 | 3 | 20 |
GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 1.92e-02 | 1.00e+00 | 5.687 | 1 | 1 | 20 |
GO:0016071 | mRNA metabolic process | 1.92e-02 | 1.00e+00 | 3.208 | 2 | 8 | 223 |
GO:0001502 | cartilage condensation | 1.92e-02 | 1.00e+00 | 5.687 | 1 | 1 | 20 |
GO:0032757 | positive regulation of interleukin-8 production | 1.92e-02 | 1.00e+00 | 5.687 | 1 | 1 | 20 |
GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 1.92e-02 | 1.00e+00 | 5.687 | 1 | 1 | 20 |
GO:0000123 | histone acetyltransferase complex | 2.02e-02 | 1.00e+00 | 5.616 | 1 | 6 | 21 |
GO:0045648 | positive regulation of erythrocyte differentiation | 2.02e-02 | 1.00e+00 | 5.616 | 1 | 1 | 21 |
GO:0030316 | osteoclast differentiation | 2.12e-02 | 1.00e+00 | 5.549 | 1 | 2 | 22 |
GO:0045787 | positive regulation of cell cycle | 2.12e-02 | 1.00e+00 | 5.549 | 1 | 2 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 2.12e-02 | 1.00e+00 | 5.549 | 1 | 2 | 22 |
GO:0001205 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | 2.12e-02 | 1.00e+00 | 5.549 | 1 | 4 | 22 |
GO:0003713 | transcription coactivator activity | 2.15e-02 | 1.00e+00 | 3.120 | 2 | 24 | 237 |
GO:0071479 | cellular response to ionizing radiation | 2.21e-02 | 1.00e+00 | 5.485 | 1 | 1 | 23 |
GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 2.21e-02 | 1.00e+00 | 5.485 | 1 | 1 | 23 |
GO:2000379 | positive regulation of reactive oxygen species metabolic process | 2.21e-02 | 1.00e+00 | 5.485 | 1 | 2 | 23 |
GO:0008134 | transcription factor binding | 2.23e-02 | 1.00e+00 | 3.090 | 2 | 18 | 242 |
GO:0016070 | RNA metabolic process | 2.32e-02 | 1.00e+00 | 3.060 | 2 | 8 | 247 |
GO:0035329 | hippo signaling | 2.50e-02 | 1.00e+00 | 5.308 | 1 | 5 | 26 |
GO:0051209 | release of sequestered calcium ion into cytosol | 2.50e-02 | 1.00e+00 | 5.308 | 1 | 1 | 26 |
GO:0000166 | nucleotide binding | 2.54e-02 | 1.00e+00 | 2.992 | 2 | 13 | 259 |
GO:0003677 | DNA binding | 2.55e-02 | 1.00e+00 | 1.758 | 4 | 49 | 1218 |
GO:0051149 | positive regulation of muscle cell differentiation | 2.59e-02 | 1.00e+00 | 5.254 | 1 | 4 | 27 |
GO:0000077 | DNA damage checkpoint | 2.59e-02 | 1.00e+00 | 5.254 | 1 | 1 | 27 |
GO:0071339 | MLL1 complex | 2.59e-02 | 1.00e+00 | 5.254 | 1 | 6 | 27 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 2.63e-02 | 1.00e+00 | 2.964 | 2 | 23 | 264 |
GO:0043507 | positive regulation of JUN kinase activity | 2.69e-02 | 1.00e+00 | 5.201 | 1 | 1 | 28 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 2.77e-02 | 1.00e+00 | 2.145 | 3 | 39 | 699 |
GO:0031663 | lipopolysaccharide-mediated signaling pathway | 2.78e-02 | 1.00e+00 | 5.151 | 1 | 2 | 29 |
GO:0010827 | regulation of glucose transport | 2.87e-02 | 1.00e+00 | 5.102 | 1 | 4 | 30 |
GO:0001890 | placenta development | 2.97e-02 | 1.00e+00 | 5.055 | 1 | 3 | 31 |
GO:0042594 | response to starvation | 2.97e-02 | 1.00e+00 | 5.055 | 1 | 4 | 31 |
GO:0002062 | chondrocyte differentiation | 3.06e-02 | 1.00e+00 | 5.009 | 1 | 2 | 32 |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 3.06e-02 | 1.00e+00 | 5.009 | 1 | 2 | 32 |
GO:0001104 | RNA polymerase II transcription cofactor activity | 3.16e-02 | 1.00e+00 | 4.964 | 1 | 8 | 33 |
GO:0042692 | muscle cell differentiation | 3.25e-02 | 1.00e+00 | 4.921 | 1 | 4 | 34 |
GO:0016592 | mediator complex | 3.35e-02 | 1.00e+00 | 4.879 | 1 | 10 | 35 |
GO:0035556 | intracellular signal transduction | 3.39e-02 | 1.00e+00 | 2.766 | 2 | 9 | 303 |
GO:0007077 | mitotic nuclear envelope disassembly | 3.44e-02 | 1.00e+00 | 4.839 | 1 | 4 | 36 |
GO:0008645 | hexose transport | 3.72e-02 | 1.00e+00 | 4.723 | 1 | 4 | 39 |
GO:0035019 | somatic stem cell maintenance | 3.82e-02 | 1.00e+00 | 4.687 | 1 | 6 | 40 |
GO:0007519 | skeletal muscle tissue development | 3.82e-02 | 1.00e+00 | 4.687 | 1 | 2 | 40 |
GO:0031124 | mRNA 3'-end processing | 4.00e-02 | 1.00e+00 | 4.616 | 1 | 2 | 42 |
GO:0003723 | RNA binding | 4.23e-02 | 1.00e+00 | 2.591 | 2 | 18 | 342 |
GO:0005634 | nucleus | 4.26e-02 | 1.00e+00 | 0.854 | 8 | 159 | 4559 |
GO:0006369 | termination of RNA polymerase II transcription | 4.28e-02 | 1.00e+00 | 4.517 | 1 | 2 | 45 |
GO:0043565 | sequence-specific DNA binding | 4.32e-02 | 1.00e+00 | 2.574 | 2 | 11 | 346 |
GO:0043525 | positive regulation of neuron apoptotic process | 4.38e-02 | 1.00e+00 | 4.485 | 1 | 4 | 46 |
GO:0000902 | cell morphogenesis | 4.65e-02 | 1.00e+00 | 4.394 | 1 | 4 | 49 |
GO:0006521 | regulation of cellular amino acid metabolic process | 4.75e-02 | 1.00e+00 | 4.365 | 1 | 1 | 50 |
GO:0006986 | response to unfolded protein | 4.75e-02 | 1.00e+00 | 4.365 | 1 | 4 | 50 |
GO:0005737 | cytoplasm | 4.77e-02 | 1.00e+00 | 0.937 | 7 | 124 | 3767 |
GO:0034976 | response to endoplasmic reticulum stress | 4.84e-02 | 1.00e+00 | 4.336 | 1 | 2 | 51 |
GO:0045454 | cell redox homeostasis | 4.84e-02 | 1.00e+00 | 4.336 | 1 | 1 | 51 |
GO:0051028 | mRNA transport | 4.93e-02 | 1.00e+00 | 4.308 | 1 | 4 | 52 |
GO:0009611 | response to wounding | 4.93e-02 | 1.00e+00 | 4.308 | 1 | 5 | 52 |
GO:0000186 | activation of MAPKK activity | 5.12e-02 | 1.00e+00 | 4.254 | 1 | 2 | 54 |
GO:0051403 | stress-activated MAPK cascade | 5.12e-02 | 1.00e+00 | 4.254 | 1 | 2 | 54 |
GO:0015758 | glucose transport | 5.21e-02 | 1.00e+00 | 4.227 | 1 | 4 | 55 |
GO:0000502 | proteasome complex | 5.49e-02 | 1.00e+00 | 4.151 | 1 | 3 | 58 |
GO:0006396 | RNA processing | 5.58e-02 | 1.00e+00 | 4.126 | 1 | 5 | 59 |
GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | 5.58e-02 | 1.00e+00 | 4.126 | 1 | 6 | 59 |
GO:0006987 | activation of signaling protein activity involved in unfolded protein response | 5.76e-02 | 1.00e+00 | 4.078 | 1 | 2 | 61 |
GO:0000776 | kinetochore | 5.95e-02 | 1.00e+00 | 4.031 | 1 | 5 | 63 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 6.04e-02 | 1.00e+00 | 4.009 | 1 | 1 | 64 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 6.13e-02 | 1.00e+00 | 3.986 | 1 | 2 | 65 |
GO:0034146 | toll-like receptor 5 signaling pathway | 6.13e-02 | 1.00e+00 | 3.986 | 1 | 4 | 65 |
GO:0034166 | toll-like receptor 10 signaling pathway | 6.13e-02 | 1.00e+00 | 3.986 | 1 | 4 | 65 |
GO:0000777 | condensed chromosome kinetochore | 6.40e-02 | 1.00e+00 | 3.921 | 1 | 3 | 68 |
GO:0018105 | peptidyl-serine phosphorylation | 6.50e-02 | 1.00e+00 | 3.900 | 1 | 2 | 69 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 6.59e-02 | 1.00e+00 | 3.879 | 1 | 2 | 70 |
GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway | 6.68e-02 | 1.00e+00 | 3.859 | 1 | 4 | 71 |
GO:0038124 | toll-like receptor TLR6:TLR2 signaling pathway | 6.68e-02 | 1.00e+00 | 3.859 | 1 | 4 | 71 |
GO:0000165 | MAPK cascade | 6.77e-02 | 1.00e+00 | 3.839 | 1 | 2 | 72 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 6.77e-02 | 1.00e+00 | 3.839 | 1 | 1 | 72 |
GO:0034162 | toll-like receptor 9 signaling pathway | 6.77e-02 | 1.00e+00 | 3.839 | 1 | 4 | 72 |
GO:0034134 | toll-like receptor 2 signaling pathway | 6.86e-02 | 1.00e+00 | 3.819 | 1 | 4 | 73 |
GO:0000981 | sequence-specific DNA binding RNA polymerase II transcription factor activity | 6.95e-02 | 1.00e+00 | 3.799 | 1 | 4 | 74 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 6.95e-02 | 1.00e+00 | 3.799 | 1 | 2 | 74 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 7.04e-02 | 1.00e+00 | 3.780 | 1 | 1 | 75 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 7.04e-02 | 1.00e+00 | 3.780 | 1 | 1 | 75 |
GO:0007265 | Ras protein signal transduction | 7.04e-02 | 1.00e+00 | 3.780 | 1 | 3 | 75 |
GO:0016020 | membrane | 7.08e-02 | 1.00e+00 | 1.294 | 4 | 46 | 1681 |
GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 7.13e-02 | 1.00e+00 | 3.761 | 1 | 3 | 76 |
GO:0071013 | catalytic step 2 spliceosome | 7.31e-02 | 1.00e+00 | 3.723 | 1 | 7 | 78 |
GO:0002756 | MyD88-independent toll-like receptor signaling pathway | 7.31e-02 | 1.00e+00 | 3.723 | 1 | 3 | 78 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 7.40e-02 | 1.00e+00 | 3.705 | 1 | 2 | 79 |
GO:0034138 | toll-like receptor 3 signaling pathway | 7.40e-02 | 1.00e+00 | 3.705 | 1 | 3 | 79 |
GO:0030968 | endoplasmic reticulum unfolded protein response | 7.40e-02 | 1.00e+00 | 3.705 | 1 | 2 | 79 |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | 7.49e-02 | 1.00e+00 | 3.687 | 1 | 5 | 80 |
GO:0071222 | cellular response to lipopolysaccharide | 7.59e-02 | 1.00e+00 | 3.669 | 1 | 4 | 81 |
GO:0009653 | anatomical structure morphogenesis | 7.77e-02 | 1.00e+00 | 3.634 | 1 | 2 | 83 |
GO:0050821 | protein stabilization | 8.21e-02 | 1.00e+00 | 3.549 | 1 | 3 | 88 |
GO:0048471 | perinuclear region of cytoplasm | 8.35e-02 | 1.00e+00 | 2.037 | 2 | 8 | 502 |
GO:0000187 | activation of MAPK activity | 8.39e-02 | 1.00e+00 | 3.517 | 1 | 3 | 90 |
GO:0006928 | cellular component movement | 8.48e-02 | 1.00e+00 | 3.501 | 1 | 3 | 91 |
GO:0001649 | osteoblast differentiation | 8.57e-02 | 1.00e+00 | 3.485 | 1 | 5 | 92 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 8.57e-02 | 1.00e+00 | 3.485 | 1 | 1 | 92 |
GO:0005770 | late endosome | 8.66e-02 | 1.00e+00 | 3.470 | 1 | 2 | 93 |
GO:0034142 | toll-like receptor 4 signaling pathway | 8.93e-02 | 1.00e+00 | 3.424 | 1 | 4 | 96 |
GO:0006935 | chemotaxis | 9.73e-02 | 1.00e+00 | 3.294 | 1 | 3 | 105 |
GO:0006915 | apoptotic process | 9.91e-02 | 1.00e+00 | 1.892 | 2 | 12 | 555 |
GO:0002224 | toll-like receptor signaling pathway | 1.01e-01 | 1.00e+00 | 3.241 | 1 | 4 | 109 |
GO:0030529 | ribonucleoprotein complex | 1.03e-01 | 1.00e+00 | 3.201 | 1 | 5 | 112 |
GO:0005635 | nuclear envelope | 1.04e-01 | 1.00e+00 | 3.189 | 1 | 5 | 113 |
GO:0000209 | protein polyubiquitination | 1.07e-01 | 1.00e+00 | 3.151 | 1 | 3 | 116 |
GO:0006006 | glucose metabolic process | 1.09e-01 | 1.00e+00 | 3.126 | 1 | 5 | 118 |
GO:0006325 | chromatin organization | 1.09e-01 | 1.00e+00 | 3.126 | 1 | 12 | 118 |
GO:0007050 | cell cycle arrest | 1.14e-01 | 1.00e+00 | 3.055 | 1 | 5 | 124 |
GO:0005524 | ATP binding | 1.25e-01 | 1.00e+00 | 1.252 | 3 | 31 | 1298 |
GO:0016055 | Wnt signaling pathway | 1.26e-01 | 1.00e+00 | 2.900 | 1 | 4 | 138 |
GO:0010628 | positive regulation of gene expression | 1.33e-01 | 1.00e+00 | 2.819 | 1 | 7 | 146 |
GO:0007166 | cell surface receptor signaling pathway | 1.34e-01 | 1.00e+00 | 2.809 | 1 | 4 | 147 |
GO:0000082 | G1/S transition of mitotic cell cycle | 1.35e-01 | 1.00e+00 | 2.790 | 1 | 3 | 149 |
GO:0042981 | regulation of apoptotic process | 1.36e-01 | 1.00e+00 | 2.780 | 1 | 4 | 150 |
GO:0034641 | cellular nitrogen compound metabolic process | 1.54e-01 | 1.00e+00 | 2.591 | 1 | 2 | 171 |
GO:0007049 | cell cycle | 1.56e-01 | 1.00e+00 | 2.566 | 1 | 6 | 174 |
GO:0005667 | transcription factor complex | 1.57e-01 | 1.00e+00 | 2.558 | 1 | 17 | 175 |
GO:0031625 | ubiquitin protein ligase binding | 1.60e-01 | 1.00e+00 | 2.533 | 1 | 5 | 178 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 1.65e-01 | 1.00e+00 | 2.485 | 1 | 22 | 184 |
GO:0001525 | angiogenesis | 1.70e-01 | 1.00e+00 | 2.431 | 1 | 7 | 191 |
GO:0030168 | platelet activation | 1.82e-01 | 1.00e+00 | 2.329 | 1 | 6 | 205 |
GO:0019221 | cytokine-mediated signaling pathway | 1.94e-01 | 1.00e+00 | 2.221 | 1 | 8 | 221 |
GO:0043025 | neuronal cell body | 2.13e-01 | 1.00e+00 | 2.072 | 1 | 9 | 245 |
GO:0007165 | signal transduction | 2.19e-01 | 1.00e+00 | 1.184 | 2 | 13 | 907 |
GO:0005975 | carbohydrate metabolic process | 2.20e-01 | 1.00e+00 | 2.026 | 1 | 8 | 253 |
GO:0048011 | neurotrophin TRK receptor signaling pathway | 2.32e-01 | 1.00e+00 | 1.937 | 1 | 7 | 269 |
GO:0005739 | mitochondrion | 2.52e-01 | 1.00e+00 | 1.046 | 2 | 23 | 998 |
GO:0004674 | protein serine/threonine kinase activity | 2.61e-01 | 1.00e+00 | 1.742 | 1 | 6 | 308 |
GO:0003682 | chromatin binding | 2.75e-01 | 1.00e+00 | 1.656 | 1 | 19 | 327 |
GO:0008283 | cell proliferation | 2.75e-01 | 1.00e+00 | 1.651 | 1 | 14 | 328 |
GO:0015031 | protein transport | 2.85e-01 | 1.00e+00 | 1.595 | 1 | 11 | 341 |
GO:0005925 | focal adhesion | 3.02e-01 | 1.00e+00 | 1.493 | 1 | 9 | 366 |
GO:0046982 | protein heterodimerization activity | 3.12e-01 | 1.00e+00 | 1.439 | 1 | 8 | 380 |
GO:0009986 | cell surface | 3.27e-01 | 1.00e+00 | 1.358 | 1 | 9 | 402 |
GO:0044281 | small molecule metabolic process | 3.31e-01 | 1.00e+00 | 0.767 | 2 | 20 | 1211 |
GO:0045892 | negative regulation of transcription, DNA-templated | 3.34e-01 | 1.00e+00 | 1.319 | 1 | 24 | 413 |
GO:0043066 | negative regulation of apoptotic process | 3.42e-01 | 1.00e+00 | 1.281 | 1 | 16 | 424 |
GO:0055085 | transmembrane transport | 3.49e-01 | 1.00e+00 | 1.244 | 1 | 8 | 435 |
GO:0007596 | blood coagulation | 3.62e-01 | 1.00e+00 | 1.179 | 1 | 11 | 455 |
GO:0006468 | protein phosphorylation | 3.65e-01 | 1.00e+00 | 1.163 | 1 | 10 | 460 |
GO:0044267 | cellular protein metabolic process | 3.74e-01 | 1.00e+00 | 1.120 | 1 | 20 | 474 |
GO:0045893 | positive regulation of transcription, DNA-templated | 3.76e-01 | 1.00e+00 | 1.108 | 1 | 24 | 478 |
GO:0042802 | identical protein binding | 3.80e-01 | 1.00e+00 | 1.090 | 1 | 19 | 484 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 4.32e-01 | 1.00e+00 | 0.854 | 1 | 37 | 570 |
GO:0045087 | innate immune response | 4.46e-01 | 1.00e+00 | 0.790 | 1 | 15 | 596 |
GO:0005730 | nucleolus | 4.84e-01 | 1.00e+00 | 0.328 | 2 | 66 | 1641 |
GO:0070062 | extracellular vesicular exosome | 7.03e-01 | 1.00e+00 | -0.220 | 2 | 57 | 2400 |
GO:0046872 | metal ion binding | 7.36e-01 | 1.00e+00 | -0.343 | 1 | 29 | 1307 |
GO:0006351 | transcription, DNA-templated | 7.72e-01 | 1.00e+00 | -0.489 | 1 | 57 | 1446 |
GO:0005886 | plasma membrane | 9.37e-01 | 1.00e+00 | -1.326 | 1 | 49 | 2582 |