int-snw-5905

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.933 1.40e-16 1.42e-04 1.42e-03
chia-screen-data-Fav-int-snw-5905 subnetwork

Genes (14)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
HCFC1 3054 40-2.9253.44971YesYes
MAP3K4 4216 2-1.9402.976101--
MED19 219541 30-2.6573.449115Yes-
PSMD2 5708 47-4.1723.157386YesYes
LUC7L3 51747 33-3.5233.44918Yes-
NUP93 9688 1-1.8362.93371--
YAP1 10413 94-4.2563.53853Yes-
NXF1 10482 10-2.4263.53865YesYes
[ RANGAP1 ] 5905 1-1.5962.93374--
SRSF3 6428 73-2.9923.53854Yes-
HNRNPU 3192 76-2.8693.538139Yes-
POU5F1 5460 133-5.1483.538179YesYes
MAPK14 1432 4-1.9022.955272--
DDIT3 1649 60-2.8253.504343YesYes

Interactions (18)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RANGAP1 5905 NXF1 10482 pp -- int.Intact: MI:0914(association)
MAPK14 1432 RANGAP1 5905 pp -- int.I2D: BioGrid_Yeast
MAPK14 1432 DDIT3 1649 pp -- int.I2D: BCI, BioGrid, HPRD;
int.HPRD: in vitro
PSMD2 5708 RANGAP1 5905 pp -- int.I2D: BioGrid_Yeast
SRSF3 6428 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
MAP3K4 4216 RANGAP1 5905 pp -- int.I2D: BioGrid_Yeast
SRSF3 6428 NXF1 10482 pp -- int.I2D: MINT, HPRD;
int.Mint: MI:0407(direct interaction), MI:0915(physical association)
HCFC1 3054 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU 3192 NXF1 10482 pp -- int.Intact: MI:0914(association)
RANGAP1 5905 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
MAPK14 1432 MAP3K4 4216 pp -- int.I2D: BioGrid_Yeast
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
HCFC1 3054 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
LUC7L3 51747 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
RANGAP1 5905 NUP93 9688 pp -- int.I2D: BioGrid_Yeast

Related GO terms (249)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm1.03e-071.49e-033.0999641082
GO:0005643nuclear pore2.07e-052.98e-015.76131157
GO:0010467gene expression2.12e-053.06e-013.208645669
GO:0042789mRNA transcription from RNA polymerase II promoter6.78e-059.78e-017.3082213
GO:0044212transcription regulatory region DNA binding5.14e-041.00e+004.201317168
GO:0016607nuclear speck5.51e-041.00e+004.167312172
GO:0006366transcription from RNA polymerase II promoter5.58e-041.00e+003.298430419
GO:0005515protein binding9.66e-041.00e+001.037121986024
GO:0060795cell fate commitment involved in formation of primary germ layer9.71e-041.00e+0010.009111
GO:0038066p38MAPK cascade9.71e-041.00e+0010.009111
GO:2000016negative regulation of determination of dorsal identity9.71e-041.00e+0010.009111
GO:0014835myoblast differentiation involved in skeletal muscle regeneration9.71e-041.00e+0010.009111
GO:0090308regulation of methylation-dependent chromatin silencing9.71e-041.00e+0010.009111
GO:0005098Ran GTPase activator activity9.71e-041.00e+0010.009111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway9.71e-041.00e+0010.009111
GO:0060965negative regulation of gene silencing by miRNA9.71e-041.00e+0010.009111
GO:0008380RNA splicing1.25e-031.00e+003.761322228
GO:0006406mRNA export from nucleus1.55e-031.00e+005.0782461
GO:0010468regulation of gene expression1.92e-031.00e+004.9212268
GO:0019100male germ-line sex determination1.94e-031.00e+009.009112
GO:0060242contact inhibition1.94e-031.00e+009.009112
GO:0019046release from viral latency1.94e-031.00e+009.009122
GO:0009786regulation of asymmetric cell division1.94e-031.00e+009.009112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.94e-031.00e+009.009112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.94e-031.00e+009.009112
GO:0003729mRNA binding2.15e-031.00e+004.8392472
GO:0044822poly(A) RNA binding2.39e-031.00e+002.2865501056
GO:0090400stress-induced premature senescence2.91e-031.00e+008.424113
GO:0060913cardiac cell fate determination2.91e-031.00e+008.424113
GO:0003130BMP signaling pathway involved in heart induction2.91e-031.00e+008.424113
GO:0090090negative regulation of canonical Wnt signaling pathway3.05e-031.00e+004.5822886
GO:0000922spindle pole3.12e-031.00e+004.5662487
GO:0060718chorionic trophoblast cell differentiation3.88e-031.00e+008.009114
GO:0070461SAGA-type complex4.84e-031.00e+007.687125
GO:0001714endodermal cell fate specification4.84e-031.00e+007.687115
GO:0043620regulation of DNA-templated transcription in response to stress4.84e-031.00e+007.687115
GO:0070934CRD-mediated mRNA stabilization4.84e-031.00e+007.687125
GO:0051525NFAT protein binding4.84e-031.00e+007.687125
GO:1901741positive regulation of myoblast fusion4.84e-031.00e+007.687115
GO:0005829cytosol5.09e-031.00e+001.5317862496
GO:0045944positive regulation of transcription from RNA polymerase II promoter5.72e-031.00e+002.385441789
GO:0000278mitotic cell cycle5.76e-031.00e+002.983315391
GO:0070937CRD-mediated mRNA stability complex5.81e-031.00e+007.424136
GO:0032853positive regulation of Ran GTPase activity5.81e-031.00e+007.424116
GO:0046826negative regulation of protein export from nucleus6.78e-031.00e+007.201127
GO:0016973poly(A)+ mRNA export from nucleus7.74e-031.00e+007.009118
GO:0051292nuclear pore complex assembly7.74e-031.00e+007.009148
GO:0001955blood vessel maturation7.74e-031.00e+007.009118
GO:1900745positive regulation of p38MAPK cascade7.74e-031.00e+007.009118
GO:0070688MLL5-L complex7.74e-031.00e+007.009118
GO:0043254regulation of protein complex assembly7.74e-031.00e+007.009118
GO:0010831positive regulation of myotube differentiation7.74e-031.00e+007.009118
GO:0043995histone acetyltransferase activity (H4-K5 specific)8.70e-031.00e+006.839159
GO:0046972histone acetyltransferase activity (H4-K16 specific)8.70e-031.00e+006.839159
GO:0042405nuclear inclusion body8.70e-031.00e+006.839129
GO:0010225response to UV-C8.70e-031.00e+006.839129
GO:0048188Set1C/COMPASS complex8.70e-031.00e+006.839149
GO:0006983ER overload response8.70e-031.00e+006.839119
GO:0043996histone acetyltransferase activity (H4-K8 specific)8.70e-031.00e+006.839159
GO:0017056structural constituent of nuclear pore8.70e-031.00e+006.839129
GO:0032495response to muramyl dipeptide8.70e-031.00e+006.839129
GO:0006974cellular response to DNA damage stimulus9.12e-031.00e+003.77027151
GO:0035413positive regulation of catenin import into nucleus9.67e-031.00e+006.6871210
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway1.06e-021.00e+006.5491111
GO:0045663positive regulation of myoblast differentiation1.06e-021.00e+006.5491211
GO:0045662negative regulation of myoblast differentiation1.06e-021.00e+006.5491311
GO:0019395fatty acid oxidation1.06e-021.00e+006.5491211
GO:0004707MAP kinase activity1.06e-021.00e+006.5491111
GO:0042770signal transduction in response to DNA damage1.06e-021.00e+006.5491111
GO:0060391positive regulation of SMAD protein import into nucleus1.06e-021.00e+006.5491411
GO:0000398mRNA splicing, via spliceosome1.07e-021.00e+003.651215164
GO:0031965nuclear membrane1.12e-021.00e+003.616210168
GO:00709353'-UTR-mediated mRNA stabilization1.16e-021.00e+006.4241312
GO:0034399nuclear periphery1.16e-021.00e+006.4241512
GO:0005838proteasome regulatory particle1.16e-021.00e+006.4241112
GO:0035198miRNA binding1.16e-021.00e+006.4241112
GO:0051146striated muscle cell differentiation1.16e-021.00e+006.4241112
GO:0003714transcription corepressor activity1.25e-021.00e+003.533211178
GO:0071480cellular response to gamma radiation1.26e-021.00e+006.3081113
GO:0004708MAP kinase kinase activity1.26e-021.00e+006.3081113
GO:0030234enzyme regulator activity1.26e-021.00e+006.3081213
GO:0000346transcription export complex1.26e-021.00e+006.3081113
GO:0006355regulation of transcription, DNA-templated1.30e-021.00e+002.047443997
GO:0005685U1 snRNP1.35e-021.00e+006.2011114
GO:0016032viral process1.35e-021.00e+002.533326534
GO:0005487nucleocytoplasmic transporter activity1.35e-021.00e+006.2011314
GO:0043981histone H4-K5 acetylation1.45e-021.00e+006.1021515
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.45e-021.00e+006.1021315
GO:0042307positive regulation of protein import into nucleus1.45e-021.00e+006.1021415
GO:0001824blastocyst development1.45e-021.00e+006.1021215
GO:0043982histone H4-K8 acetylation1.45e-021.00e+006.1021515
GO:0006376mRNA splice site selection1.45e-021.00e+006.1021115
GO:0043274phospholipase binding1.54e-021.00e+006.0091116
GO:0042176regulation of protein catabolic process1.54e-021.00e+006.0091216
GO:0043536positive regulation of blood vessel endothelial cell migration1.64e-021.00e+005.9211317
GO:0022624proteasome accessory complex1.64e-021.00e+005.9211117
GO:0004709MAP kinase kinase kinase activity1.73e-021.00e+005.8391218
GO:0043984histone H4-K16 acetylation1.83e-021.00e+005.7611519
GO:0051090regulation of sequence-specific DNA binding transcription factor activity1.92e-021.00e+005.6871320
GO:0048010vascular endothelial growth factor receptor signaling pathway1.92e-021.00e+005.6871120
GO:0016071mRNA metabolic process1.92e-021.00e+003.20828223
GO:0001502cartilage condensation1.92e-021.00e+005.6871120
GO:0032757positive regulation of interleukin-8 production1.92e-021.00e+005.6871120
GO:0035924cellular response to vascular endothelial growth factor stimulus1.92e-021.00e+005.6871120
GO:0000123histone acetyltransferase complex2.02e-021.00e+005.6161621
GO:0045648positive regulation of erythrocyte differentiation2.02e-021.00e+005.6161121
GO:0030316osteoclast differentiation2.12e-021.00e+005.5491222
GO:0045787positive regulation of cell cycle2.12e-021.00e+005.5491222
GO:0036464cytoplasmic ribonucleoprotein granule2.12e-021.00e+005.5491222
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription2.12e-021.00e+005.5491422
GO:0003713transcription coactivator activity2.15e-021.00e+003.120224237
GO:0071479cellular response to ionizing radiation2.21e-021.00e+005.4851123
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress2.21e-021.00e+005.4851123
GO:2000379positive regulation of reactive oxygen species metabolic process2.21e-021.00e+005.4851223
GO:0008134transcription factor binding2.23e-021.00e+003.090218242
GO:0016070RNA metabolic process2.32e-021.00e+003.06028247
GO:0035329hippo signaling2.50e-021.00e+005.3081526
GO:0051209release of sequestered calcium ion into cytosol2.50e-021.00e+005.3081126
GO:0000166nucleotide binding2.54e-021.00e+002.992213259
GO:0003677DNA binding2.55e-021.00e+001.7584491218
GO:0051149positive regulation of muscle cell differentiation2.59e-021.00e+005.2541427
GO:0000077DNA damage checkpoint2.59e-021.00e+005.2541127
GO:0071339MLL1 complex2.59e-021.00e+005.2541627
GO:0006357regulation of transcription from RNA polymerase II promoter2.63e-021.00e+002.964223264
GO:0043507positive regulation of JUN kinase activity2.69e-021.00e+005.2011128
GO:0003700sequence-specific DNA binding transcription factor activity2.77e-021.00e+002.145339699
GO:0031663lipopolysaccharide-mediated signaling pathway2.78e-021.00e+005.1511229
GO:0010827regulation of glucose transport2.87e-021.00e+005.1021430
GO:0001890placenta development2.97e-021.00e+005.0551331
GO:0042594response to starvation2.97e-021.00e+005.0551431
GO:0002062chondrocyte differentiation3.06e-021.00e+005.0091232
GO:1903507negative regulation of nucleic acid-templated transcription3.06e-021.00e+005.0091232
GO:0001104RNA polymerase II transcription cofactor activity3.16e-021.00e+004.9641833
GO:0042692muscle cell differentiation3.25e-021.00e+004.9211434
GO:0016592mediator complex3.35e-021.00e+004.87911035
GO:0035556intracellular signal transduction3.39e-021.00e+002.76629303
GO:0007077mitotic nuclear envelope disassembly3.44e-021.00e+004.8391436
GO:0008645hexose transport3.72e-021.00e+004.7231439
GO:0035019somatic stem cell maintenance3.82e-021.00e+004.6871640
GO:0007519skeletal muscle tissue development3.82e-021.00e+004.6871240
GO:0031124mRNA 3'-end processing4.00e-021.00e+004.6161242
GO:0003723RNA binding4.23e-021.00e+002.591218342
GO:0005634nucleus4.26e-021.00e+000.85481594559
GO:0006369termination of RNA polymerase II transcription4.28e-021.00e+004.5171245
GO:0043565sequence-specific DNA binding4.32e-021.00e+002.574211346
GO:0043525positive regulation of neuron apoptotic process4.38e-021.00e+004.4851446
GO:0000902cell morphogenesis4.65e-021.00e+004.3941449
GO:0006521regulation of cellular amino acid metabolic process4.75e-021.00e+004.3651150
GO:0006986response to unfolded protein4.75e-021.00e+004.3651450
GO:0005737cytoplasm4.77e-021.00e+000.93771243767
GO:0034976response to endoplasmic reticulum stress4.84e-021.00e+004.3361251
GO:0045454cell redox homeostasis4.84e-021.00e+004.3361151
GO:0051028mRNA transport4.93e-021.00e+004.3081452
GO:0009611response to wounding4.93e-021.00e+004.3081552
GO:0000186activation of MAPKK activity5.12e-021.00e+004.2541254
GO:0051403stress-activated MAPK cascade5.12e-021.00e+004.2541254
GO:0015758glucose transport5.21e-021.00e+004.2271455
GO:0000502proteasome complex5.49e-021.00e+004.1511358
GO:0006396RNA processing5.58e-021.00e+004.1261559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity5.58e-021.00e+004.1261659
GO:0006987activation of signaling protein activity involved in unfolded protein response5.76e-021.00e+004.0781261
GO:0000776kinetochore5.95e-021.00e+004.0311563
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest6.04e-021.00e+004.0091164
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.13e-021.00e+003.9861265
GO:0034146toll-like receptor 5 signaling pathway6.13e-021.00e+003.9861465
GO:0034166toll-like receptor 10 signaling pathway6.13e-021.00e+003.9861465
GO:0000777condensed chromosome kinetochore6.40e-021.00e+003.9211368
GO:0018105peptidyl-serine phosphorylation6.50e-021.00e+003.9001269
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.59e-021.00e+003.8791270
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway6.68e-021.00e+003.8591471
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway6.68e-021.00e+003.8591471
GO:0000165MAPK cascade6.77e-021.00e+003.8391272
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent6.77e-021.00e+003.8391172
GO:0034162toll-like receptor 9 signaling pathway6.77e-021.00e+003.8391472
GO:0034134toll-like receptor 2 signaling pathway6.86e-021.00e+003.8191473
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity6.95e-021.00e+003.7991474
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.95e-021.00e+003.7991274
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process7.04e-021.00e+003.7801175
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I7.04e-021.00e+003.7801175
GO:0007265Ras protein signal transduction7.04e-021.00e+003.7801375
GO:0016020membrane7.08e-021.00e+001.2944461681
GO:0035666TRIF-dependent toll-like receptor signaling pathway7.13e-021.00e+003.7611376
GO:0071013catalytic step 2 spliceosome7.31e-021.00e+003.7231778
GO:0002756MyD88-independent toll-like receptor signaling pathway7.31e-021.00e+003.7231378
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process7.40e-021.00e+003.7051279
GO:0034138toll-like receptor 3 signaling pathway7.40e-021.00e+003.7051379
GO:0030968endoplasmic reticulum unfolded protein response7.40e-021.00e+003.7051279
GO:0002755MyD88-dependent toll-like receptor signaling pathway7.49e-021.00e+003.6871580
GO:0071222cellular response to lipopolysaccharide7.59e-021.00e+003.6691481
GO:0009653anatomical structure morphogenesis7.77e-021.00e+003.6341283
GO:0050821protein stabilization8.21e-021.00e+003.5491388
GO:0048471perinuclear region of cytoplasm8.35e-021.00e+002.03728502
GO:0000187activation of MAPK activity8.39e-021.00e+003.5171390
GO:0006928cellular component movement8.48e-021.00e+003.5011391
GO:0001649osteoblast differentiation8.57e-021.00e+003.4851592
GO:0002474antigen processing and presentation of peptide antigen via MHC class I8.57e-021.00e+003.4851192
GO:0005770late endosome8.66e-021.00e+003.4701293
GO:0034142toll-like receptor 4 signaling pathway8.93e-021.00e+003.4241496
GO:0006935chemotaxis9.73e-021.00e+003.29413105
GO:0006915apoptotic process9.91e-021.00e+001.892212555
GO:0002224toll-like receptor signaling pathway1.01e-011.00e+003.24114109
GO:0030529ribonucleoprotein complex1.03e-011.00e+003.20115112
GO:0005635nuclear envelope1.04e-011.00e+003.18915113
GO:0000209protein polyubiquitination1.07e-011.00e+003.15113116
GO:0006006glucose metabolic process1.09e-011.00e+003.12615118
GO:0006325chromatin organization1.09e-011.00e+003.126112118
GO:0007050cell cycle arrest1.14e-011.00e+003.05515124
GO:0005524ATP binding1.25e-011.00e+001.2523311298
GO:0016055Wnt signaling pathway1.26e-011.00e+002.90014138
GO:0010628positive regulation of gene expression1.33e-011.00e+002.81917146
GO:0007166cell surface receptor signaling pathway1.34e-011.00e+002.80914147
GO:0000082G1/S transition of mitotic cell cycle1.35e-011.00e+002.79013149
GO:0042981regulation of apoptotic process1.36e-011.00e+002.78014150
GO:0034641cellular nitrogen compound metabolic process1.54e-011.00e+002.59112171
GO:0007049cell cycle1.56e-011.00e+002.56616174
GO:0005667transcription factor complex1.57e-011.00e+002.558117175
GO:0031625ubiquitin protein ligase binding1.60e-011.00e+002.53315178
GO:0006367transcription initiation from RNA polymerase II promoter1.65e-011.00e+002.485122184
GO:0001525angiogenesis1.70e-011.00e+002.43117191
GO:0030168platelet activation1.82e-011.00e+002.32916205
GO:0019221cytokine-mediated signaling pathway1.94e-011.00e+002.22118221
GO:0043025neuronal cell body2.13e-011.00e+002.07219245
GO:0007165signal transduction2.19e-011.00e+001.184213907
GO:0005975carbohydrate metabolic process2.20e-011.00e+002.02618253
GO:0048011neurotrophin TRK receptor signaling pathway2.32e-011.00e+001.93717269
GO:0005739mitochondrion2.52e-011.00e+001.046223998
GO:0004674protein serine/threonine kinase activity2.61e-011.00e+001.74216308
GO:0003682chromatin binding2.75e-011.00e+001.656119327
GO:0008283cell proliferation2.75e-011.00e+001.651114328
GO:0015031protein transport2.85e-011.00e+001.595111341
GO:0005925focal adhesion3.02e-011.00e+001.49319366
GO:0046982protein heterodimerization activity3.12e-011.00e+001.43918380
GO:0009986cell surface3.27e-011.00e+001.35819402
GO:0044281small molecule metabolic process3.31e-011.00e+000.7672201211
GO:0045892negative regulation of transcription, DNA-templated3.34e-011.00e+001.319124413
GO:0043066negative regulation of apoptotic process3.42e-011.00e+001.281116424
GO:0055085transmembrane transport3.49e-011.00e+001.24418435
GO:0007596blood coagulation3.62e-011.00e+001.179111455
GO:0006468protein phosphorylation3.65e-011.00e+001.163110460
GO:0044267cellular protein metabolic process3.74e-011.00e+001.120120474
GO:0045893positive regulation of transcription, DNA-templated3.76e-011.00e+001.108124478
GO:0042802identical protein binding3.80e-011.00e+001.090119484
GO:0000122negative regulation of transcription from RNA polymerase II promoter4.32e-011.00e+000.854137570
GO:0045087innate immune response4.46e-011.00e+000.790115596
GO:0005730nucleolus4.84e-011.00e+000.3282661641
GO:0070062extracellular vesicular exosome7.03e-011.00e+00-0.2202572400
GO:0046872metal ion binding7.36e-011.00e+00-0.3431291307
GO:0006351transcription, DNA-templated7.72e-011.00e+00-0.4891571446
GO:0005886plasma membrane9.37e-011.00e+00-1.3261492582