int-snw-57180

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.958	7.33e-17	1.02e-04	1.12e-03

chia-screen-data-Fav-int-snw-57180 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
LARS	51520	14	-2.574	3.157	105	Yes	Yes
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
DBNL	28988	1	-1.645	2.958	93	-	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
YY1	7528	24	-2.572	3.120	114	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
[ ACTR3B ]	57180	1	-1.444	2.958	56	-	-
CDKN2A	1029	2	-1.774	2.959	126	-	-

Interactions (10)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CDKN2A	1029	YY1	7528	pp	--	int.I2D: BioGrid, BIND, BCI
DBNL	28988	ACTR3B	57180	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
CDKN2A	1029	ACTR3B	57180	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: IntAct
PSMD2	5708	ACTR3B	57180	pp	--	int.I2D: BioGrid_Yeast
NFRKB	4798	YY1	7528	pp	--	int.I2D: BioGrid
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
PSMD2	5708	LARS	51520	pp	--	int.I2D: BioGrid_Yeast
CDKN2A	1029	HNRNPU	3192	pp	--	int.Intact: MI:0915(physical association)

Related GO terms (183)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0031011	Ino80 complex	3.92e-05	5.65e-01	7.687	2	6	14
GO:0044212	transcription regulatory region DNA binding	1.75e-04	1.00e+00	4.687	3	17	168
GO:0005654	nucleoplasm	4.31e-04	1.00e+00	2.737	5	64	1082
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.93e-04	1.00e+00	10.494	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.93e-04	1.00e+00	10.494	1	1	1
GO:0003677	DNA binding	7.48e-04	1.00e+00	2.566	5	49	1218
GO:0010467	gene expression	7.70e-04	1.00e+00	3.108	4	45	669
GO:0034696	response to prostaglandin F	1.39e-03	1.00e+00	9.494	1	1	2
GO:0006429	leucyl-tRNA aminoacylation	1.39e-03	1.00e+00	9.494	1	1	2
GO:0060242	contact inhibition	1.39e-03	1.00e+00	9.494	1	1	2
GO:0006403	RNA localization	1.39e-03	1.00e+00	9.494	1	1	2
GO:0009786	regulation of asymmetric cell division	1.39e-03	1.00e+00	9.494	1	1	2
GO:0004823	leucine-tRNA ligase activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0055105	ubiquitin-protein transferase inhibitor activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0035985	senescence-associated heterochromatin focus	2.08e-03	1.00e+00	8.909	1	1	3
GO:0035986	senescence-associated heterochromatin focus assembly	2.08e-03	1.00e+00	8.909	1	1	3
GO:0060913	cardiac cell fate determination	2.08e-03	1.00e+00	8.909	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.08e-03	1.00e+00	8.909	1	1	3
GO:2000111	positive regulation of macrophage apoptotic process	2.08e-03	1.00e+00	8.909	1	1	3
GO:0005515	protein binding	2.41e-03	1.00e+00	1.108	9	198	6024
GO:0071800	podosome assembly	2.77e-03	1.00e+00	8.494	1	1	4
GO:2000774	positive regulation of cellular senescence	2.77e-03	1.00e+00	8.494	1	1	4
GO:0000209	protein polyubiquitination	2.77e-03	1.00e+00	4.636	2	3	116
GO:0033088	negative regulation of immature T cell proliferation in thymus	2.77e-03	1.00e+00	8.494	1	1	4
GO:0005829	cytosol	2.97e-03	1.00e+00	1.794	6	86	2496
GO:0001714	endodermal cell fate specification	3.46e-03	1.00e+00	8.172	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.46e-03	1.00e+00	8.172	1	2	5
GO:1902510	regulation of apoptotic DNA fragmentation	3.46e-03	1.00e+00	8.172	1	1	5
GO:0034393	positive regulation of smooth muscle cell apoptotic process	3.46e-03	1.00e+00	8.172	1	2	5
GO:0097371	MDM2/MDM4 family protein binding	3.46e-03	1.00e+00	8.172	1	1	5
GO:0070937	CRD-mediated mRNA stability complex	4.15e-03	1.00e+00	7.909	1	3	6
GO:0000082	G1/S transition of mitotic cell cycle	4.52e-03	1.00e+00	4.275	2	3	149
GO:0006974	cellular response to DNA damage stimulus	4.64e-03	1.00e+00	4.256	2	7	151
GO:0046825	regulation of protein export from nucleus	4.84e-03	1.00e+00	7.687	1	2	7
GO:0051444	negative regulation of ubiquitin-protein transferase activity	4.84e-03	1.00e+00	7.687	1	1	7
GO:0002161	aminoacyl-tRNA editing activity	4.84e-03	1.00e+00	7.687	1	2	7
GO:0010389	regulation of G2/M transition of mitotic cell cycle	5.53e-03	1.00e+00	7.494	1	1	8
GO:0005667	transcription factor complex	6.18e-03	1.00e+00	4.043	2	17	175
GO:0010225	response to UV-C	6.22e-03	1.00e+00	7.324	1	2	9
GO:0006450	regulation of translational fidelity	6.22e-03	1.00e+00	7.324	1	2	9
GO:0048103	somatic stem cell division	6.22e-03	1.00e+00	7.324	1	1	9
GO:0000400	four-way junction DNA binding	6.22e-03	1.00e+00	7.324	1	1	9
GO:0003714	transcription corepressor activity	6.39e-03	1.00e+00	4.018	2	11	178
GO:0035413	positive regulation of catenin import into nucleus	6.91e-03	1.00e+00	7.172	1	2	10
GO:0090399	replicative senescence	6.91e-03	1.00e+00	7.172	1	1	10
GO:0033235	positive regulation of protein sumoylation	7.60e-03	1.00e+00	7.035	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	7.60e-03	1.00e+00	7.035	1	4	11
GO:0001953	negative regulation of cell-matrix adhesion	8.29e-03	1.00e+00	6.909	1	2	12
GO:0005838	proteasome regulatory particle	8.29e-03	1.00e+00	6.909	1	1	12
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	8.29e-03	1.00e+00	6.909	1	2	12
GO:0035198	miRNA binding	8.29e-03	1.00e+00	6.909	1	1	12
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	8.29e-03	1.00e+00	6.909	1	1	12
GO:0071480	cellular response to gamma radiation	8.98e-03	1.00e+00	6.794	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	8.98e-03	1.00e+00	6.794	1	2	13
GO:0030889	negative regulation of B cell proliferation	8.98e-03	1.00e+00	6.794	1	1	13
GO:0030234	enzyme regulator activity	8.98e-03	1.00e+00	6.794	1	2	13
GO:0030665	clathrin-coated vesicle membrane	8.98e-03	1.00e+00	6.794	1	3	13
GO:0001824	blastocyst development	1.04e-02	1.00e+00	6.587	1	2	15
GO:0042176	regulation of protein catabolic process	1.10e-02	1.00e+00	6.494	1	2	16
GO:0051276	chromosome organization	1.10e-02	1.00e+00	6.494	1	2	16
GO:0048593	camera-type eye morphogenesis	1.10e-02	1.00e+00	6.494	1	1	16
GO:0002102	podosome	1.10e-02	1.00e+00	6.494	1	1	16
GO:0003713	transcription coactivator activity	1.11e-02	1.00e+00	3.605	2	24	237
GO:0008134	transcription factor binding	1.15e-02	1.00e+00	3.575	2	18	242
GO:0016601	Rac protein signal transduction	1.17e-02	1.00e+00	6.407	1	1	17
GO:0022624	proteasome accessory complex	1.17e-02	1.00e+00	6.407	1	1	17
GO:0090398	cellular senescence	1.24e-02	1.00e+00	6.324	1	1	18
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	1.31e-02	1.00e+00	6.246	1	2	19
GO:0071158	positive regulation of cell cycle arrest	1.31e-02	1.00e+00	6.246	1	2	19
GO:0003779	actin binding	1.38e-02	1.00e+00	3.439	2	10	266
GO:0005634	nucleus	1.44e-02	1.00e+00	1.147	7	159	4559
GO:0042326	negative regulation of phosphorylation	1.45e-02	1.00e+00	6.102	1	1	21
GO:0008637	apoptotic mitochondrial changes	1.45e-02	1.00e+00	6.102	1	2	21
GO:0031648	protein destabilization	1.45e-02	1.00e+00	6.102	1	1	21
GO:0036464	cytoplasmic ribonucleoprotein granule	1.52e-02	1.00e+00	6.035	1	2	22
GO:0051059	NF-kappaB binding	1.72e-02	1.00e+00	5.850	1	3	25
GO:0031519	PcG protein complex	1.72e-02	1.00e+00	5.850	1	1	25
GO:0035329	hippo signaling	1.79e-02	1.00e+00	5.794	1	5	26
GO:0034644	cellular response to UV	2.06e-02	1.00e+00	5.587	1	1	30
GO:0031647	regulation of protein stability	2.06e-02	1.00e+00	5.587	1	4	30
GO:0048812	neuron projection morphogenesis	2.13e-02	1.00e+00	5.540	1	1	31
GO:0070534	protein K63-linked ubiquitination	2.13e-02	1.00e+00	5.540	1	1	31
GO:0016604	nuclear body	2.13e-02	1.00e+00	5.540	1	3	31
GO:0002376	immune system process	2.20e-02	1.00e+00	5.494	1	3	32
GO:1903507	negative regulation of nucleic acid-templated transcription	2.20e-02	1.00e+00	5.494	1	2	32
GO:0003723	RNA binding	2.22e-02	1.00e+00	3.076	2	18	342
GO:0007416	synapse assembly	2.27e-02	1.00e+00	5.450	1	3	33
GO:0005737	cytoplasm	2.44e-02	1.00e+00	1.200	6	124	3767
GO:0007257	activation of JUN kinase activity	2.47e-02	1.00e+00	5.324	1	5	36
GO:0008047	enzyme activator activity	2.67e-02	1.00e+00	5.209	1	3	39
GO:0035019	somatic stem cell maintenance	2.74e-02	1.00e+00	5.172	1	6	40
GO:0006355	regulation of transcription, DNA-templated	2.74e-02	1.00e+00	2.118	3	43	997
GO:0000278	mitotic cell cycle	2.86e-02	1.00e+00	2.883	2	15	391
GO:0006418	tRNA aminoacylation for protein translation	2.88e-02	1.00e+00	5.102	1	3	42
GO:0044822	poly(A) RNA binding	3.18e-02	1.00e+00	2.035	3	50	1056
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	3.21e-02	1.00e+00	4.940	1	2	47
GO:0006366	transcription from RNA polymerase II promoter	3.25e-02	1.00e+00	2.783	2	30	419
GO:0006521	regulation of cellular amino acid metabolic process	3.41e-02	1.00e+00	4.850	1	1	50
GO:0009611	response to wounding	3.55e-02	1.00e+00	4.794	1	5	52
GO:0000724	double-strand break repair via homologous recombination	3.75e-02	1.00e+00	4.713	1	2	55
GO:0002039	p53 binding	3.75e-02	1.00e+00	4.713	1	4	55
GO:0000502	proteasome complex	3.95e-02	1.00e+00	4.636	1	3	58
GO:0006396	RNA processing	4.02e-02	1.00e+00	4.612	1	5	59
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	4.02e-02	1.00e+00	4.612	1	5	59
GO:0042995	cell projection	4.08e-02	1.00e+00	4.587	1	3	60
GO:0032088	negative regulation of NF-kappaB transcription factor activity	4.28e-02	1.00e+00	4.517	1	3	63
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.35e-02	1.00e+00	4.494	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.42e-02	1.00e+00	4.472	1	2	65
GO:0006310	DNA recombination	4.42e-02	1.00e+00	4.472	1	7	65
GO:0006469	negative regulation of protein kinase activity	4.42e-02	1.00e+00	4.472	1	4	65
GO:0010468	regulation of gene expression	4.62e-02	1.00e+00	4.407	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.75e-02	1.00e+00	4.365	1	2	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.88e-02	1.00e+00	4.324	1	1	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.02e-02	1.00e+00	4.285	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.02e-02	1.00e+00	4.285	1	2	74
GO:0002020	protease binding	5.02e-02	1.00e+00	4.285	1	6	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.08e-02	1.00e+00	4.265	1	1	75
GO:0007265	Ras protein signal transduction	5.08e-02	1.00e+00	4.265	1	3	75
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	5.21e-02	1.00e+00	4.227	1	3	77
GO:0071013	catalytic step 2 spliceosome	5.28e-02	1.00e+00	4.209	1	7	78
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.35e-02	1.00e+00	4.190	1	2	79
GO:0005524	ATP binding	5.40e-02	1.00e+00	1.737	3	31	1298
GO:0001726	ruffle	5.41e-02	1.00e+00	4.172	1	4	80
GO:0006915	apoptotic process	5.42e-02	1.00e+00	2.378	2	12	555
GO:0009653	anatomical structure morphogenesis	5.61e-02	1.00e+00	4.119	1	2	83
GO:0009952	anterior/posterior pattern specification	5.61e-02	1.00e+00	4.119	1	4	83
GO:0050821	protein stabilization	5.94e-02	1.00e+00	4.035	1	3	88
GO:0016363	nuclear matrix	6.14e-02	1.00e+00	3.986	1	6	91
GO:0051015	actin filament binding	6.20e-02	1.00e+00	3.971	1	3	92
GO:0001649	osteoblast differentiation	6.20e-02	1.00e+00	3.971	1	5	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.20e-02	1.00e+00	3.971	1	1	92
GO:0006364	rRNA processing	6.33e-02	1.00e+00	3.940	1	3	94
GO:0005938	cell cortex	6.98e-02	1.00e+00	3.794	1	5	104
GO:0014069	postsynaptic density	7.05e-02	1.00e+00	3.780	1	1	105
GO:0006897	endocytosis	7.11e-02	1.00e+00	3.766	1	7	106
GO:0030308	negative regulation of cell growth	7.37e-02	1.00e+00	3.713	1	6	110
GO:0030529	ribonucleoprotein complex	7.50e-02	1.00e+00	3.687	1	5	112
GO:0003700	sequence-specific DNA binding transcription factor activity	8.15e-02	1.00e+00	2.045	2	39	699
GO:0007050	cell cycle arrest	8.27e-02	1.00e+00	3.540	1	5	124
GO:0030027	lamellipodium	8.34e-02	1.00e+00	3.528	1	7	125
GO:0042981	regulation of apoptotic process	9.93e-02	1.00e+00	3.265	1	4	150
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.00e-01	1.00e+00	1.870	2	41	789
GO:0008022	protein C-terminus binding	1.06e-01	1.00e+00	3.163	1	8	161
GO:0000398	mRNA splicing, via spliceosome	1.08e-01	1.00e+00	3.137	1	15	164
GO:0034641	cellular nitrogen compound metabolic process	1.12e-01	1.00e+00	3.076	1	2	171
GO:0031625	ubiquitin protein ligase binding	1.17e-01	1.00e+00	3.018	1	5	178
GO:0019904	protein domain specific binding	1.17e-01	1.00e+00	3.010	1	8	179
GO:0006367	transcription initiation from RNA polymerase II promoter	1.21e-01	1.00e+00	2.971	1	22	184
GO:0016071	mRNA metabolic process	1.44e-01	1.00e+00	2.693	1	8	223
GO:0008380	RNA splicing	1.47e-01	1.00e+00	2.661	1	22	228
GO:0030425	dendrite	1.49e-01	1.00e+00	2.649	1	6	230
GO:0016070	RNA metabolic process	1.59e-01	1.00e+00	2.546	1	8	247
GO:0006281	DNA repair	1.67e-01	1.00e+00	2.466	1	14	261
GO:0007283	spermatogenesis	1.68e-01	1.00e+00	2.461	1	3	262
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.69e-01	1.00e+00	2.450	1	23	264
GO:0006954	inflammatory response	1.76e-01	1.00e+00	2.380	1	6	277
GO:0005856	cytoskeleton	1.84e-01	1.00e+00	2.309	1	9	291
GO:0043234	protein complex	1.87e-01	1.00e+00	2.290	1	11	295
GO:0030154	cell differentiation	1.90e-01	1.00e+00	2.261	1	5	301
GO:0019901	protein kinase binding	1.99e-01	1.00e+00	2.186	1	18	317
GO:0008283	cell proliferation	2.06e-01	1.00e+00	2.137	1	14	328
GO:0030054	cell junction	2.10e-01	1.00e+00	2.102	1	5	336
GO:0043565	sequence-specific DNA binding	2.16e-01	1.00e+00	2.060	1	11	346
GO:0008285	negative regulation of cell proliferation	2.20e-01	1.00e+00	2.031	1	10	353
GO:0070062	extracellular vesicular exosome	2.24e-01	1.00e+00	0.850	3	57	2400
GO:0000139	Golgi membrane	2.24e-01	1.00e+00	1.998	1	7	361
GO:0008150	biological_process	2.39e-01	1.00e+00	1.891	1	4	389
GO:0009986	cell surface	2.46e-01	1.00e+00	1.843	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.52e-01	1.00e+00	1.804	1	24	413
GO:0043066	negative regulation of apoptotic process	2.58e-01	1.00e+00	1.766	1	16	424
GO:0006351	transcription, DNA-templated	2.65e-01	1.00e+00	0.996	2	57	1446
GO:0003674	molecular_function	2.69e-01	1.00e+00	1.700	1	1	444
GO:0045893	positive regulation of transcription, DNA-templated	2.86e-01	1.00e+00	1.593	1	24	478
GO:0016032	viral process	3.14e-01	1.00e+00	1.433	1	26	534
GO:0005730	nucleolus	3.18e-01	1.00e+00	0.814	2	66	1641
GO:0016020	membrane	3.28e-01	1.00e+00	0.779	2	46	1681
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.32e-01	1.00e+00	1.339	1	37	570
GO:0005739	mitochondrion	5.12e-01	1.00e+00	0.531	1	23	998
GO:0008270	zinc ion binding	5.12e-01	1.00e+00	0.533	1	27	997
GO:0044281	small molecule metabolic process	5.84e-01	1.00e+00	0.252	1	20	1211
GO:0005886	plasma membrane	8.61e-01	1.00e+00	-0.840	1	49	2582

chia-Fav

int-snw-57180

Statistics

Genes (10)

Interactions (10)

Related GO terms (183)