int-snw-51450

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.944	1.07e-16	1.24e-04	1.29e-03

chia-screen-data-Fav-int-snw-51450 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
[ PRRX2 ]	51450	1	-1.316	2.944	9	-	-
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
SOX10	6663	2	-1.490	3.050	33	-	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
SON	6651	9	-3.844	3.108	9	Yes	Yes
CDK12	51755	6	-2.714	2.944	15	Yes	-
SUMO1	7341	7	-1.696	3.050	439	-	-

Interactions (12)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
SUMO1	7341	CDK12	51755	pp	--	int.I2D: BioGrid
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
POU5F1	5460	SOX10	6663	pp	--	int.I2D: HPRD, BCI; int.Ravasi: -; int.HPRD: in vitro
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU	3192	SUMO1	7341	pp	--	int.I2D: BioGrid
SON	6651	SUMO1	7341	pp	--	int.I2D: BioGrid
SOX10	6663	PRRX2	51450	pp	--	int.I2D: HPRD; int.Ravasi: -; int.HPRD: yeast 2-hybrid
SOX10	6663	SUMO1	7341	pp	--	int.I2D: BCI, HPRD, MINT; int.Mint: MI:0566(sumoylation reaction); int.HPRD: in vivo
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
POU5F1	5460	SUMO1	7341	pp	--	int.I2D: BioGrid, BioGrid_Mouse

Related GO terms (159)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016607	nuclear speck	6.04e-06	8.71e-02	4.930	4	12	172
GO:0006366	transcription from RNA polymerase II promoter	8.08e-06	1.17e-01	3.968	5	30	419
GO:0008380	RNA splicing	1.84e-05	2.65e-01	4.524	4	22	228
GO:0005654	nucleoplasm	5.85e-05	8.43e-01	2.862	6	64	1082
GO:0005634	nucleus	7.76e-05	1.00e+00	1.524	10	159	4559
GO:0006355	regulation of transcription, DNA-templated	5.08e-04	1.00e+00	2.717	5	43	997
GO:0003713	transcription coactivator activity	6.56e-04	1.00e+00	4.053	3	24	237
GO:0044822	poly(A) RNA binding	6.63e-04	1.00e+00	2.634	5	50	1056
GO:0008134	transcription factor binding	6.97e-04	1.00e+00	4.023	3	18	242
GO:0060795	cell fate commitment involved in formation of primary germ layer	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	7.63e-04	1.00e+00	10.357	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	7.63e-04	1.00e+00	10.357	1	1	1
GO:0005515	protein binding	1.10e-03	1.00e+00	1.122	10	198	6024
GO:0060242	contact inhibition	1.52e-03	1.00e+00	9.357	1	1	2
GO:0019046	release from viral latency	1.52e-03	1.00e+00	9.357	1	2	2
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	1.52e-03	1.00e+00	9.357	1	1	2
GO:0090204	protein localization to nuclear pore	1.52e-03	1.00e+00	9.357	1	1	2
GO:0031315	extrinsic component of mitochondrial outer membrane	1.52e-03	1.00e+00	9.357	1	1	2
GO:0009786	regulation of asymmetric cell division	1.52e-03	1.00e+00	9.357	1	1	2
GO:0002944	cyclin K-CDK12 complex	1.52e-03	1.00e+00	9.357	1	1	2
GO:0014015	positive regulation of gliogenesis	1.52e-03	1.00e+00	9.357	1	1	2
GO:0009653	anatomical structure morphogenesis	1.74e-03	1.00e+00	4.982	2	2	83
GO:0003723	RNA binding	1.89e-03	1.00e+00	3.524	3	18	342
GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	2.29e-03	1.00e+00	8.772	1	1	3
GO:0060913	cardiac cell fate determination	2.29e-03	1.00e+00	8.772	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.29e-03	1.00e+00	8.772	1	1	3
GO:0001650	fibrillar center	2.29e-03	1.00e+00	8.772	1	1	3
GO:0051726	regulation of cell cycle	2.37e-03	1.00e+00	4.757	2	5	97
GO:0030578	PML body organization	3.05e-03	1.00e+00	8.357	1	1	4
GO:0070461	SAGA-type complex	3.81e-03	1.00e+00	8.035	1	2	5
GO:0001714	endodermal cell fate specification	3.81e-03	1.00e+00	8.035	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.81e-03	1.00e+00	8.035	1	2	5
GO:0043405	regulation of MAP kinase activity	3.81e-03	1.00e+00	8.035	1	1	5
GO:0050733	RS domain binding	4.57e-03	1.00e+00	7.772	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	4.57e-03	1.00e+00	7.772	1	3	6
GO:0005730	nucleolus	4.85e-03	1.00e+00	1.998	5	66	1641
GO:0070688	MLL5-L complex	6.09e-03	1.00e+00	7.357	1	1	8
GO:0043254	regulation of protein complex assembly	6.09e-03	1.00e+00	7.357	1	1	8
GO:0006397	mRNA processing	6.30e-03	1.00e+00	4.035	2	10	160
GO:0000398	mRNA splicing, via spliceosome	6.61e-03	1.00e+00	3.999	2	15	164
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	6.85e-03	1.00e+00	7.187	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	6.85e-03	1.00e+00	7.187	1	5	9
GO:0048188	Set1C/COMPASS complex	6.85e-03	1.00e+00	7.187	1	4	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	6.85e-03	1.00e+00	7.187	1	5	9
GO:0044212	transcription regulatory region DNA binding	6.92e-03	1.00e+00	3.964	2	17	168
GO:0035413	positive regulation of catenin import into nucleus	7.60e-03	1.00e+00	7.035	1	2	10
GO:0048484	enteric nervous system development	7.60e-03	1.00e+00	7.035	1	1	10
GO:0031625	ubiquitin protein ligase binding	7.74e-03	1.00e+00	3.881	2	5	178
GO:0019789	SUMO ligase activity	8.36e-03	1.00e+00	6.897	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	8.36e-03	1.00e+00	6.897	1	4	11
GO:0035198	miRNA binding	9.12e-03	1.00e+00	6.772	1	1	12
GO:0071480	cellular response to gamma radiation	9.87e-03	1.00e+00	6.656	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	9.87e-03	1.00e+00	6.656	1	2	13
GO:0031334	positive regulation of protein complex assembly	9.87e-03	1.00e+00	6.656	1	2	13
GO:0003677	DNA binding	1.03e-02	1.00e+00	2.106	4	49	1218
GO:0048546	digestive tract morphogenesis	1.06e-02	1.00e+00	6.549	1	1	14
GO:0031011	Ino80 complex	1.06e-02	1.00e+00	6.549	1	6	14
GO:0043981	histone H4-K5 acetylation	1.14e-02	1.00e+00	6.450	1	5	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	1.14e-02	1.00e+00	6.450	1	3	15
GO:0001824	blastocyst development	1.14e-02	1.00e+00	6.450	1	2	15
GO:0043982	histone H4-K8 acetylation	1.14e-02	1.00e+00	6.450	1	5	15
GO:0043274	phospholipase binding	1.21e-02	1.00e+00	6.357	1	1	16
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	1.21e-02	1.00e+00	6.357	1	1	16
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	1.21e-02	1.00e+00	6.357	1	2	16
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	1.21e-02	1.00e+00	6.357	1	1	16
GO:0010467	gene expression	1.24e-02	1.00e+00	2.556	3	45	669
GO:0030332	cyclin binding	1.36e-02	1.00e+00	6.187	1	1	18
GO:0002052	positive regulation of neuroblast proliferation	1.36e-02	1.00e+00	6.187	1	1	18
GO:0003700	sequence-specific DNA binding transcription factor activity	1.40e-02	1.00e+00	2.492	3	39	699
GO:0043984	histone H4-K16 acetylation	1.44e-02	1.00e+00	6.109	1	5	19
GO:0030318	melanocyte differentiation	1.44e-02	1.00e+00	6.109	1	3	19
GO:0042474	middle ear morphogenesis	1.59e-02	1.00e+00	5.964	1	1	21
GO:0048844	artery morphogenesis	1.59e-02	1.00e+00	5.964	1	1	21
GO:0000123	histone acetyltransferase complex	1.59e-02	1.00e+00	5.964	1	6	21
GO:0006281	DNA repair	1.61e-02	1.00e+00	3.329	2	14	261
GO:0045787	positive regulation of cell cycle	1.67e-02	1.00e+00	5.897	1	2	22
GO:0043484	regulation of RNA splicing	1.67e-02	1.00e+00	5.897	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.67e-02	1.00e+00	5.897	1	4	22
GO:0048709	oligodendrocyte differentiation	1.74e-02	1.00e+00	5.833	1	2	23
GO:0045880	positive regulation of smoothened signaling pathway	1.74e-02	1.00e+00	5.833	1	1	23
GO:0007422	peripheral nervous system development	1.89e-02	1.00e+00	5.713	1	2	25
GO:0016925	protein sumoylation	1.89e-02	1.00e+00	5.713	1	2	25
GO:0048589	developmental growth	1.89e-02	1.00e+00	5.713	1	2	25
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.93e-02	1.00e+00	2.318	3	41	789
GO:0043392	negative regulation of DNA binding	1.97e-02	1.00e+00	5.656	1	4	26
GO:0035329	hippo signaling	1.97e-02	1.00e+00	5.656	1	5	26
GO:0048701	embryonic cranial skeleton morphogenesis	2.04e-02	1.00e+00	5.602	1	1	27
GO:0071339	MLL1 complex	2.04e-02	1.00e+00	5.602	1	6	27
GO:0001755	neural crest cell migration	2.12e-02	1.00e+00	5.549	1	1	28
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	2.34e-02	1.00e+00	5.402	1	1	31
GO:0002053	positive regulation of mesenchymal cell proliferation	2.41e-02	1.00e+00	5.357	1	1	32
GO:1903507	negative regulation of nucleic acid-templated transcription	2.41e-02	1.00e+00	5.357	1	2	32
GO:0003682	chromatin binding	2.46e-02	1.00e+00	3.004	2	19	327
GO:0043565	sequence-specific DNA binding	2.74e-02	1.00e+00	2.922	2	11	346
GO:0032880	regulation of protein localization	2.79e-02	1.00e+00	5.147	1	2	37
GO:0030326	embryonic limb morphogenesis	2.79e-02	1.00e+00	5.147	1	1	37
GO:0048469	cell maturation	2.86e-02	1.00e+00	5.109	1	1	38
GO:0035019	somatic stem cell maintenance	3.01e-02	1.00e+00	5.035	1	6	40
GO:0031124	mRNA 3'-end processing	3.16e-02	1.00e+00	4.964	1	2	42
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	3.31e-02	1.00e+00	4.897	1	3	44
GO:0006369	termination of RNA polymerase II transcription	3.38e-02	1.00e+00	4.865	1	2	45
GO:0042472	inner ear morphogenesis	3.75e-02	1.00e+00	4.713	1	2	50
GO:0045892	negative regulation of transcription, DNA-templated	3.79e-02	1.00e+00	2.667	2	24	413
GO:0000910	cytokinesis	3.82e-02	1.00e+00	4.684	1	2	51
GO:0000226	microtubule cytoskeleton organization	3.90e-02	1.00e+00	4.656	1	2	52
GO:0009611	response to wounding	3.90e-02	1.00e+00	4.656	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.97e-02	1.00e+00	4.629	1	5	53
GO:0043066	negative regulation of apoptotic process	3.98e-02	1.00e+00	2.629	2	16	424
GO:0051216	cartilage development	4.12e-02	1.00e+00	4.575	1	1	55
GO:0005643	nuclear pore	4.26e-02	1.00e+00	4.524	1	11	57
GO:0006396	RNA processing	4.41e-02	1.00e+00	4.474	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	4.41e-02	1.00e+00	4.474	1	6	59
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	4.56e-02	1.00e+00	4.426	1	4	61
GO:0006406	mRNA export from nucleus	4.56e-02	1.00e+00	4.426	1	4	61
GO:0060333	interferon-gamma-mediated signaling pathway	4.63e-02	1.00e+00	4.402	1	3	62
GO:0006310	DNA recombination	4.85e-02	1.00e+00	4.334	1	7	65
GO:0042802	identical protein binding	5.06e-02	1.00e+00	2.438	2	19	484
GO:0010468	regulation of gene expression	5.07e-02	1.00e+00	4.269	1	2	68
GO:0060021	palate development	5.36e-02	1.00e+00	4.187	1	1	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.50e-02	1.00e+00	4.147	1	4	74
GO:0002020	protease binding	5.50e-02	1.00e+00	4.147	1	6	74
GO:0071013	catalytic step 2 spliceosome	5.79e-02	1.00e+00	4.071	1	7	78
GO:0090090	negative regulation of canonical Wnt signaling pathway	6.37e-02	1.00e+00	3.930	1	8	86
GO:0016605	PML body	6.51e-02	1.00e+00	3.897	1	3	88
GO:0050821	protein stabilization	6.51e-02	1.00e+00	3.897	1	3	88
GO:0001649	osteoblast differentiation	6.80e-02	1.00e+00	3.833	1	5	92
GO:0003676	nucleic acid binding	7.87e-02	1.00e+00	3.615	1	2	107
GO:0030529	ribonucleoprotein complex	8.22e-02	1.00e+00	3.549	1	5	112
GO:0006325	chromatin organization	8.64e-02	1.00e+00	3.474	1	12	118
GO:0045202	synapse	9.90e-02	1.00e+00	3.269	1	5	136
GO:0010628	positive regulation of gene expression	1.06e-01	1.00e+00	3.167	1	7	146
GO:0006974	cellular response to DNA damage stimulus	1.09e-01	1.00e+00	3.118	1	7	151
GO:0046777	protein autophosphorylation	1.14e-01	1.00e+00	3.053	1	4	158
GO:0043687	post-translational protein modification	1.17e-01	1.00e+00	3.017	1	5	162
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.19e-01	1.00e+00	2.990	1	12	165
GO:0031965	nuclear membrane	1.21e-01	1.00e+00	2.964	1	10	168
GO:0007049	cell cycle	1.25e-01	1.00e+00	2.914	1	6	174
GO:0005667	transcription factor complex	1.26e-01	1.00e+00	2.905	1	17	175
GO:0004672	protein kinase activity	1.27e-01	1.00e+00	2.889	1	3	177
GO:0003714	transcription corepressor activity	1.28e-01	1.00e+00	2.881	1	11	178
GO:0006367	transcription initiation from RNA polymerase II promoter	1.32e-01	1.00e+00	2.833	1	22	184
GO:0005737	cytoplasm	1.33e-01	1.00e+00	0.799	5	124	3767
GO:0001701	in utero embryonic development	1.43e-01	1.00e+00	2.706	1	8	201
GO:0019221	cytokine-mediated signaling pathway	1.56e-01	1.00e+00	2.569	1	8	221
GO:0030425	dendrite	1.62e-01	1.00e+00	2.511	1	6	230
GO:0043025	neuronal cell body	1.72e-01	1.00e+00	2.420	1	9	245
GO:0000166	nucleotide binding	1.81e-01	1.00e+00	2.340	1	13	259
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.84e-01	1.00e+00	2.312	1	23	264
GO:0006954	inflammatory response	1.92e-01	1.00e+00	2.243	1	6	277
GO:0008283	cell proliferation	2.24e-01	1.00e+00	1.999	1	14	328
GO:0005524	ATP binding	2.60e-01	1.00e+00	1.015	2	31	1298
GO:0009986	cell surface	2.67e-01	1.00e+00	1.706	1	9	402
GO:0044267	cellular protein metabolic process	3.08e-01	1.00e+00	1.468	1	20	474
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.58e-01	1.00e+00	1.202	1	37	570
GO:0016020	membrane	3.73e-01	1.00e+00	0.642	2	46	1681
GO:0005739	mitochondrion	5.46e-01	1.00e+00	0.394	1	23	998
GO:0005829	cytosol	5.92e-01	1.00e+00	0.071	2	86	2496

chia-Fav

int-snw-51450

Statistics

Genes (11)

Interactions (12)

Related GO terms (159)