Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
chia-screen-data-Fav | 2.845 | 1.28e-15 | 4.27e-04 | 3.10e-03 |
Gene Symbol | Entrez Gene ID | Frequency | chia-screen-data-Fav gene score | Best subnetwork score | Degree | Chia-Hits Primary | Chia-Hits Secondary |
---|---|---|---|---|---|---|---|
TUBB4A | 10382 | 7 | -2.312 | 2.975 | 88 | Yes | - |
EP300 | 2033 | 22 | -2.274 | 3.120 | 415 | Yes | Yes |
PSMD2 | 5708 | 47 | -4.172 | 3.157 | 386 | Yes | Yes |
RHOA | 387 | 5 | -2.408 | 2.845 | 151 | Yes | Yes |
MCRS1 | 10445 | 14 | -2.660 | 3.079 | 63 | Yes | Yes |
TNFRSF1A | 7132 | 2 | -1.846 | 2.915 | 166 | - | - |
YAP1 | 10413 | 94 | -4.256 | 3.538 | 53 | Yes | - |
[ ATF6 ] | 22926 | 1 | -1.377 | 2.845 | 26 | - | - |
TAF7 | 6879 | 3 | -2.176 | 2.899 | 38 | Yes | Yes |
INO80E | 283899 | 10 | -2.663 | 3.079 | 20 | Yes | - |
NFRKB | 4798 | 48 | -3.129 | 3.108 | 23 | Yes | Yes |
POU5F1 | 5460 | 133 | -5.148 | 3.538 | 179 | Yes | Yes |
YY1 | 7528 | 24 | -2.572 | 3.120 | 114 | Yes | Yes |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
MCRS1 | 10445 | INO80E | 283899 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
NFRKB | 4798 | INO80E | 283899 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid |
YY1 | 7528 | ATF6 | 22926 | pp | -- | int.I2D: BioGrid, HPRD, BCI; int.Ravasi: -; int.HPRD: in vivo |
TNFRSF1A | 7132 | ATF6 | 22926 | pp | -- | int.Intact: MI:0915(physical association) |
NFRKB | 4798 | MCRS1 | 10445 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid |
TAF7 | 6879 | YY1 | 7528 | pp | -- | int.Transfac: - |
EP300 | 2033 | YY1 | 7528 | pp | -- | int.I2D: BioGrid, BCI, HPRD; int.Transfac: -; int.Ravasi: -; int.HPRD: in vivo; int.DIP: MI:0218(physical interaction) |
RHOA | 387 | PSMD2 | 5708 | pp | -- | int.I2D: BioGrid_Yeast |
NFRKB | 4798 | YY1 | 7528 | pp | -- | int.I2D: BioGrid |
RHOA | 387 | TNFRSF1A | 7132 | pp | -- | int.I2D: BioGrid |
POU5F1 | 5460 | TUBB4A | 10382 | pp | -- | int.I2D: BioGrid |
TNFRSF1A | 7132 | TUBB4A | 10382 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct, MINT; int.Mint: MI:0915(physical association) |
YY1 | 7528 | INO80E | 283899 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid |
NFRKB | 4798 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
EP300 | 2033 | YAP1 | 10413 | pp | -- | int.I2D: BioGrid |
YY1 | 7528 | MCRS1 | 10445 | pp | -- | int.I2D: BioGrid |
PSMD2 | 5708 | TNFRSF1A | 7132 | pp | -- | int.I2D: BioGrid, BCI, HPRD; int.HPRD: in vitro, yeast 2-hybrid |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0031011 | Ino80 complex | 3.95e-10 | 5.70e-06 | 8.308 | 4 | 6 | 14 |
GO:0003713 | transcription coactivator activity | 1.33e-06 | 1.91e-02 | 4.549 | 5 | 24 | 237 |
GO:0044212 | transcription regulatory region DNA binding | 1.17e-05 | 1.69e-01 | 4.723 | 4 | 17 | 168 |
GO:0005515 | protein binding | 1.17e-05 | 1.68e-01 | 1.260 | 13 | 198 | 6024 |
GO:0006310 | DNA recombination | 2.42e-05 | 3.49e-01 | 5.678 | 3 | 7 | 65 |
GO:0033160 | positive regulation of protein import into nucleus, translocation | 4.11e-05 | 5.92e-01 | 7.656 | 2 | 3 | 11 |
GO:0006355 | regulation of transcription, DNA-templated | 1.21e-04 | 1.00e+00 | 2.739 | 6 | 43 | 997 |
GO:0005634 | nucleus | 1.23e-04 | 1.00e+00 | 1.421 | 11 | 159 | 4559 |
GO:0000123 | histone acetyltransferase complex | 1.56e-04 | 1.00e+00 | 6.723 | 2 | 6 | 21 |
GO:0005654 | nucleoplasm | 1.90e-04 | 1.00e+00 | 2.621 | 6 | 64 | 1082 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 2.45e-04 | 1.00e+00 | 2.988 | 5 | 39 | 699 |
GO:0071339 | MLL1 complex | 2.60e-04 | 1.00e+00 | 6.361 | 2 | 6 | 27 |
GO:0005667 | transcription factor complex | 4.59e-04 | 1.00e+00 | 4.249 | 3 | 17 | 175 |
GO:1901985 | positive regulation of protein acetylation | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0043969 | histone H2B acetylation | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0090308 | regulation of methylation-dependent chromatin silencing | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0090081 | regulation of heart induction by regulation of canonical Wnt signaling pathway | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0060965 | negative regulation of gene silencing by miRNA | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0060795 | cell fate commitment involved in formation of primary germ layer | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0060177 | regulation of angiotensin metabolic process | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0061383 | trabecula morphogenesis | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:2000629 | negative regulation of miRNA metabolic process | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0000296 | spermine transport | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0033013 | tetrapyrrole metabolic process | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0009611 | response to wounding | 9.69e-04 | 1.00e+00 | 5.415 | 2 | 5 | 52 |
GO:0016032 | viral process | 1.02e-03 | 1.00e+00 | 3.055 | 4 | 26 | 534 |
GO:0008134 | transcription factor binding | 1.18e-03 | 1.00e+00 | 3.782 | 3 | 18 | 242 |
GO:0006281 | DNA repair | 1.46e-03 | 1.00e+00 | 3.673 | 3 | 14 | 261 |
GO:0060242 | contact inhibition | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:0006403 | RNA localization | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:0009786 | regulation of asymmetric cell division | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:0090043 | regulation of tubulin deacetylation | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 2 | 2 |
GO:0071389 | cellular response to mineralocorticoid stimulus | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:0034696 | response to prostaglandin F | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:0014737 | positive regulation of muscle atrophy | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:0043120 | tumor necrosis factor binding | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:0035984 | cellular response to trichostatin A | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:0002020 | protease binding | 1.95e-03 | 1.00e+00 | 4.906 | 2 | 6 | 74 |
GO:0045471 | response to ethanol | 2.63e-03 | 1.00e+00 | 4.689 | 2 | 3 | 86 |
GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 2 | 3 |
GO:0018076 | N-terminal peptidyl-lysine acetylation | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 |
GO:0060913 | cardiac cell fate determination | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 |
GO:0010560 | positive regulation of glycoprotein biosynthetic process | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 |
GO:0033688 | regulation of osteoblast proliferation | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 |
GO:0003130 | BMP signaling pathway involved in heart induction | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 |
GO:0097157 | pre-mRNA intronic binding | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 |
GO:0038027 | apolipoprotein A-I-mediated signaling pathway | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 |
GO:0018393 | internal peptidyl-lysine acetylation | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 |
GO:0033269 | internode region of axon | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 4.27e-03 | 1.00e+00 | 2.492 | 4 | 41 | 789 |
GO:0001714 | endodermal cell fate specification | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 |
GO:0008024 | positive transcription elongation factor complex b | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 |
GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 |
GO:0065004 | protein-DNA complex assembly | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 |
GO:0043279 | response to alkaloid | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 2 | 5 |
GO:0060298 | positive regulation of sarcomere organization | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 |
GO:0032025 | response to cobalt ion | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 |
GO:0000278 | mitotic cell cycle | 4.62e-03 | 1.00e+00 | 3.090 | 3 | 15 | 391 |
GO:0006325 | chromatin organization | 4.88e-03 | 1.00e+00 | 4.233 | 2 | 12 | 118 |
GO:0036089 | cleavage furrow formation | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 2 | 6 |
GO:0006366 | transcription from RNA polymerase II promoter | 5.60e-03 | 1.00e+00 | 2.990 | 3 | 30 | 419 |
GO:0043931 | ossification involved in bone maturation | 6.29e-03 | 1.00e+00 | 7.308 | 1 | 1 | 7 |
GO:0043297 | apical junction assembly | 6.29e-03 | 1.00e+00 | 7.308 | 1 | 1 | 7 |
GO:0006475 | internal protein amino acid acetylation | 6.29e-03 | 1.00e+00 | 7.308 | 1 | 1 | 7 |
GO:0000086 | G2/M transition of mitotic cell cycle | 6.43e-03 | 1.00e+00 | 4.028 | 2 | 4 | 136 |
GO:0006351 | transcription, DNA-templated | 6.50e-03 | 1.00e+00 | 1.940 | 5 | 57 | 1446 |
GO:0006457 | protein folding | 7.09e-03 | 1.00e+00 | 3.956 | 2 | 7 | 143 |
GO:0035067 | negative regulation of histone acetylation | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 2 | 8 |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 7.28e-03 | 1.00e+00 | 3.936 | 2 | 4 | 145 |
GO:0001666 | response to hypoxia | 7.67e-03 | 1.00e+00 | 3.896 | 2 | 7 | 149 |
GO:0006974 | cellular response to DNA damage stimulus | 7.87e-03 | 1.00e+00 | 3.877 | 2 | 7 | 151 |
GO:0035259 | glucocorticoid receptor binding | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0045793 | positive regulation of cell size | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 2 | 9 |
GO:0043996 | histone acetyltransferase activity (H4-K8 specific) | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 5 | 9 |
GO:0006693 | prostaglandin metabolic process | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0043995 | histone acetyltransferase activity (H4-K5 specific) | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 5 | 9 |
GO:0046972 | histone acetyltransferase activity (H4-K16 specific) | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 5 | 9 |
GO:0060765 | regulation of androgen receptor signaling pathway | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0010225 | response to UV-C | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 2 | 9 |
GO:0042511 | positive regulation of tyrosine phosphorylation of Stat1 protein | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0000400 | four-way junction DNA binding | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0043296 | apical junction complex | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0005031 | tumor necrosis factor-activated receptor activity | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0090307 | spindle assembly involved in mitosis | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 1 | 10 |
GO:0035413 | positive regulation of catenin import into nucleus | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 2 | 10 |
GO:0016407 | acetyltransferase activity | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 2 | 10 |
GO:0043923 | positive regulation by host of viral transcription | 9.87e-03 | 1.00e+00 | 6.656 | 1 | 1 | 11 |
GO:0042975 | peroxisome proliferator activated receptor binding | 9.87e-03 | 1.00e+00 | 6.656 | 1 | 1 | 11 |
GO:0060391 | positive regulation of SMAD protein import into nucleus | 9.87e-03 | 1.00e+00 | 6.656 | 1 | 4 | 11 |
GO:0003714 | transcription corepressor activity | 1.08e-02 | 1.00e+00 | 3.640 | 2 | 11 | 178 |
GO:0005838 | proteasome regulatory particle | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 12 |
GO:0035198 | miRNA binding | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 12 |
GO:0005730 | nucleolus | 1.11e-02 | 1.00e+00 | 1.757 | 5 | 66 | 1641 |
GO:0032403 | protein complex binding | 1.14e-02 | 1.00e+00 | 3.600 | 2 | 6 | 183 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 1.15e-02 | 1.00e+00 | 3.592 | 2 | 22 | 184 |
GO:0071480 | cellular response to gamma radiation | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 1 | 13 |
GO:0042789 | mRNA transcription from RNA polymerase II promoter | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 2 | 13 |
GO:0016746 | transferase activity, transferring acyl groups | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 1 | 13 |
GO:0051019 | mitogen-activated protein kinase binding | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 2 | 13 |
GO:0030234 | enzyme regulator activity | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 2 | 13 |
GO:0006915 | apoptotic process | 1.21e-02 | 1.00e+00 | 2.584 | 3 | 12 | 555 |
GO:0033276 | transcription factor TFTC complex | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 4 | 14 |
GO:0070542 | response to fatty acid | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 1 | 14 |
GO:0032993 | protein-DNA complex | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 2 | 14 |
GO:0003924 | GTPase activity | 1.31e-02 | 1.00e+00 | 3.494 | 2 | 7 | 197 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 1.31e-02 | 1.00e+00 | 2.546 | 3 | 37 | 570 |
GO:0042809 | vitamin D receptor binding | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 6 | 15 |
GO:0043981 | histone H4-K5 acetylation | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 5 | 15 |
GO:0001824 | blastocyst development | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 2 | 15 |
GO:0043982 | histone H4-K8 acetylation | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 5 | 15 |
GO:1990090 | cellular response to nerve growth factor stimulus | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 1 | 15 |
GO:0042176 | regulation of protein catabolic process | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 2 | 16 |
GO:0043209 | myelin sheath | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 1 | 16 |
GO:0051276 | chromosome organization | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 2 | 16 |
GO:0048593 | camera-type eye morphogenesis | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 1 | 16 |
GO:0005829 | cytosol | 1.51e-02 | 1.00e+00 | 1.415 | 6 | 86 | 2496 |
GO:0050919 | negative chemotaxis | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 1 | 17 |
GO:0017022 | myosin binding | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 2 | 17 |
GO:0022624 | proteasome accessory complex | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 1 | 17 |
GO:0006184 | GTP catabolic process | 1.53e-02 | 1.00e+00 | 3.374 | 2 | 7 | 214 |
GO:0071392 | cellular response to estradiol stimulus | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 2 | 18 |
GO:0050772 | positive regulation of axonogenesis | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 1 | 18 |
GO:0030520 | intracellular estrogen receptor signaling pathway | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 4 | 18 |
GO:0045773 | positive regulation of axon extension | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 1 | 18 |
GO:0033613 | activating transcription factor binding | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 3 | 18 |
GO:0042346 | positive regulation of NF-kappaB import into nucleus | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 1 | 18 |
GO:0035035 | histone acetyltransferase binding | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 1 | 19 |
GO:0043984 | histone H4-K16 acetylation | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 5 | 19 |
GO:0035257 | nuclear hormone receptor binding | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 1 | 19 |
GO:0071549 | cellular response to dexamethasone stimulus | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 3 | 20 |
GO:0050771 | negative regulation of axonogenesis | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 1 | 20 |
GO:0010942 | positive regulation of cell death | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 1 | 20 |
GO:0032715 | negative regulation of interleukin-6 production | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 1 | 20 |
GO:0006352 | DNA-templated transcription, initiation | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 2 | 20 |
GO:0032967 | positive regulation of collagen biosynthetic process | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 3 | 21 |
GO:0045862 | positive regulation of proteolysis | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 2 | 21 |
GO:0003677 | DNA binding | 1.95e-02 | 1.00e+00 | 1.865 | 4 | 49 | 1218 |
GO:0003823 | antigen binding | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 2 | 22 |
GO:0005669 | transcription factor TFIID complex | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 4 | 22 |
GO:0043200 | response to amino acid | 2.05e-02 | 1.00e+00 | 5.592 | 1 | 1 | 23 |
GO:0043388 | positive regulation of DNA binding | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 2 | 24 |
GO:0043425 | bHLH transcription factor binding | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 1 | 24 |
GO:0031519 | PcG protein complex | 2.23e-02 | 1.00e+00 | 5.472 | 1 | 1 | 25 |
GO:0051059 | NF-kappaB binding | 2.23e-02 | 1.00e+00 | 5.472 | 1 | 3 | 25 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 2.28e-02 | 1.00e+00 | 3.071 | 2 | 23 | 264 |
GO:0035329 | hippo signaling | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 5 | 26 |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 1 | 26 |
GO:0050770 | regulation of axonogenesis | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 2 | 26 |
GO:0048565 | digestive tract development | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 2 | 26 |
GO:0046966 | thyroid hormone receptor binding | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 6 | 26 |
GO:0032467 | positive regulation of cytokinesis | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 2 | 27 |
GO:0034612 | response to tumor necrosis factor | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 2 | 27 |
GO:0007017 | microtubule-based process | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 2 | 27 |
GO:0043967 | histone H4 acetylation | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 1 | 27 |
GO:0051258 | protein polymerization | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 2 | 27 |
GO:0006954 | inflammatory response | 2.49e-02 | 1.00e+00 | 3.002 | 2 | 6 | 277 |
GO:0033209 | tumor necrosis factor-mediated signaling pathway | 2.50e-02 | 1.00e+00 | 5.308 | 1 | 1 | 28 |
GO:0050714 | positive regulation of protein secretion | 2.50e-02 | 1.00e+00 | 5.308 | 1 | 3 | 28 |
GO:0034644 | cellular response to UV | 2.67e-02 | 1.00e+00 | 5.209 | 1 | 1 | 30 |
GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 2.67e-02 | 1.00e+00 | 5.209 | 1 | 1 | 30 |
GO:0043491 | protein kinase B signaling | 2.85e-02 | 1.00e+00 | 5.116 | 1 | 2 | 32 |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 2.85e-02 | 1.00e+00 | 5.116 | 1 | 2 | 32 |
GO:0001756 | somitogenesis | 2.94e-02 | 1.00e+00 | 5.071 | 1 | 1 | 33 |
GO:0071333 | cellular response to glucose stimulus | 2.94e-02 | 1.00e+00 | 5.071 | 1 | 1 | 33 |
GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | 3.02e-02 | 1.00e+00 | 5.028 | 1 | 1 | 34 |
GO:0005525 | GTP binding | 3.07e-02 | 1.00e+00 | 2.840 | 2 | 12 | 310 |
GO:0001102 | RNA polymerase II activating transcription factor binding | 3.20e-02 | 1.00e+00 | 4.946 | 1 | 1 | 36 |
GO:0051084 | 'de novo' posttranslational protein folding | 3.29e-02 | 1.00e+00 | 4.906 | 1 | 5 | 37 |
GO:0032760 | positive regulation of tumor necrosis factor production | 3.29e-02 | 1.00e+00 | 4.906 | 1 | 2 | 37 |
GO:0031490 | chromatin DNA binding | 3.37e-02 | 1.00e+00 | 4.868 | 1 | 2 | 38 |
GO:0051496 | positive regulation of stress fiber assembly | 3.37e-02 | 1.00e+00 | 4.868 | 1 | 4 | 38 |
GO:0032092 | positive regulation of protein binding | 3.37e-02 | 1.00e+00 | 4.868 | 1 | 2 | 38 |
GO:0050681 | androgen receptor binding | 3.37e-02 | 1.00e+00 | 4.868 | 1 | 1 | 38 |
GO:0032154 | cleavage furrow | 3.37e-02 | 1.00e+00 | 4.868 | 1 | 1 | 38 |
GO:0046332 | SMAD binding | 3.55e-02 | 1.00e+00 | 4.794 | 1 | 2 | 40 |
GO:0071320 | cellular response to cAMP | 3.55e-02 | 1.00e+00 | 4.794 | 1 | 1 | 40 |
GO:0035019 | somatic stem cell maintenance | 3.55e-02 | 1.00e+00 | 4.794 | 1 | 6 | 40 |
GO:0007519 | skeletal muscle tissue development | 3.55e-02 | 1.00e+00 | 4.794 | 1 | 2 | 40 |
GO:0070301 | cellular response to hydrogen peroxide | 3.63e-02 | 1.00e+00 | 4.758 | 1 | 2 | 41 |
GO:0004402 | histone acetyltransferase activity | 3.81e-02 | 1.00e+00 | 4.689 | 1 | 6 | 43 |
GO:0021762 | substantia nigra development | 3.90e-02 | 1.00e+00 | 4.656 | 1 | 4 | 44 |
GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | 3.90e-02 | 1.00e+00 | 4.656 | 1 | 4 | 44 |
GO:0045727 | positive regulation of translation | 3.90e-02 | 1.00e+00 | 4.656 | 1 | 2 | 44 |
GO:0043966 | histone H3 acetylation | 3.98e-02 | 1.00e+00 | 4.624 | 1 | 5 | 45 |
GO:0001047 | core promoter binding | 3.98e-02 | 1.00e+00 | 4.624 | 1 | 5 | 45 |
GO:0000139 | Golgi membrane | 4.06e-02 | 1.00e+00 | 2.620 | 2 | 7 | 361 |
GO:0006950 | response to stress | 4.07e-02 | 1.00e+00 | 4.592 | 1 | 2 | 46 |
GO:0043525 | positive regulation of neuron apoptotic process | 4.07e-02 | 1.00e+00 | 4.592 | 1 | 4 | 46 |
GO:0007266 | Rho protein signal transduction | 4.16e-02 | 1.00e+00 | 4.561 | 1 | 1 | 47 |
GO:0050729 | positive regulation of inflammatory response | 4.24e-02 | 1.00e+00 | 4.531 | 1 | 2 | 48 |
GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 4.33e-02 | 1.00e+00 | 4.501 | 1 | 2 | 49 |
GO:0035690 | cellular response to drug | 4.33e-02 | 1.00e+00 | 4.501 | 1 | 3 | 49 |
GO:0006521 | regulation of cellular amino acid metabolic process | 4.42e-02 | 1.00e+00 | 4.472 | 1 | 1 | 50 |
GO:0030334 | regulation of cell migration | 4.42e-02 | 1.00e+00 | 4.472 | 1 | 5 | 50 |
GO:0007623 | circadian rhythm | 4.68e-02 | 1.00e+00 | 4.388 | 1 | 1 | 53 |
GO:0051592 | response to calcium ion | 4.85e-02 | 1.00e+00 | 4.334 | 1 | 1 | 55 |
GO:0002039 | p53 binding | 4.85e-02 | 1.00e+00 | 4.334 | 1 | 4 | 55 |
GO:0071300 | cellular response to retinoic acid | 4.85e-02 | 1.00e+00 | 4.334 | 1 | 1 | 55 |
GO:0000724 | double-strand break repair via homologous recombination | 4.85e-02 | 1.00e+00 | 4.334 | 1 | 2 | 55 |
GO:0051291 | protein heterooligomerization | 4.93e-02 | 1.00e+00 | 4.308 | 1 | 4 | 56 |
GO:0050728 | negative regulation of inflammatory response | 4.93e-02 | 1.00e+00 | 4.308 | 1 | 3 | 56 |
GO:0043627 | response to estrogen | 4.93e-02 | 1.00e+00 | 4.308 | 1 | 5 | 56 |
GO:0000502 | proteasome complex | 5.11e-02 | 1.00e+00 | 4.258 | 1 | 3 | 58 |
GO:0001078 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | 5.19e-02 | 1.00e+00 | 4.233 | 1 | 5 | 59 |
GO:0042742 | defense response to bacterium | 5.28e-02 | 1.00e+00 | 4.209 | 1 | 5 | 60 |
GO:0008013 | beta-catenin binding | 5.28e-02 | 1.00e+00 | 4.209 | 1 | 9 | 60 |
GO:0006987 | activation of signaling protein activity involved in unfolded protein response | 5.36e-02 | 1.00e+00 | 4.185 | 1 | 2 | 61 |
GO:0032481 | positive regulation of type I interferon production | 5.36e-02 | 1.00e+00 | 4.185 | 1 | 6 | 61 |
GO:0043066 | negative regulation of apoptotic process | 5.43e-02 | 1.00e+00 | 2.388 | 2 | 16 | 424 |
GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 5.53e-02 | 1.00e+00 | 4.138 | 1 | 4 | 63 |
GO:0045666 | positive regulation of neuron differentiation | 5.53e-02 | 1.00e+00 | 4.138 | 1 | 3 | 63 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 5.62e-02 | 1.00e+00 | 4.116 | 1 | 1 | 64 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.71e-02 | 1.00e+00 | 4.093 | 1 | 2 | 65 |
GO:0071260 | cellular response to mechanical stimulus | 5.71e-02 | 1.00e+00 | 4.093 | 1 | 4 | 65 |
GO:0006469 | negative regulation of protein kinase activity | 5.71e-02 | 1.00e+00 | 4.093 | 1 | 4 | 65 |
GO:0010468 | regulation of gene expression | 5.96e-02 | 1.00e+00 | 4.028 | 1 | 2 | 68 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 6.13e-02 | 1.00e+00 | 3.986 | 1 | 2 | 70 |
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | 6.22e-02 | 1.00e+00 | 3.966 | 1 | 4 | 71 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 6.30e-02 | 1.00e+00 | 3.946 | 1 | 1 | 72 |
GO:0030324 | lung development | 6.30e-02 | 1.00e+00 | 3.946 | 1 | 1 | 72 |
GO:0000785 | chromatin | 6.39e-02 | 1.00e+00 | 3.926 | 1 | 6 | 73 |
GO:0000981 | sequence-specific DNA binding RNA polymerase II transcription factor activity | 6.47e-02 | 1.00e+00 | 3.906 | 1 | 4 | 74 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 6.47e-02 | 1.00e+00 | 3.906 | 1 | 2 | 74 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 6.56e-02 | 1.00e+00 | 3.887 | 1 | 1 | 75 |
GO:0044267 | cellular protein metabolic process | 6.62e-02 | 1.00e+00 | 2.227 | 2 | 20 | 474 |
GO:0001889 | liver development | 6.72e-02 | 1.00e+00 | 3.849 | 1 | 3 | 77 |
GO:0010629 | negative regulation of gene expression | 6.72e-02 | 1.00e+00 | 3.849 | 1 | 4 | 77 |
GO:0005929 | cilium | 6.72e-02 | 1.00e+00 | 3.849 | 1 | 2 | 77 |
GO:0030968 | endoplasmic reticulum unfolded protein response | 6.89e-02 | 1.00e+00 | 3.812 | 1 | 2 | 79 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 6.89e-02 | 1.00e+00 | 3.812 | 1 | 2 | 79 |
GO:0009653 | anatomical structure morphogenesis | 7.23e-02 | 1.00e+00 | 3.741 | 1 | 2 | 83 |
GO:0009952 | anterior/posterior pattern specification | 7.23e-02 | 1.00e+00 | 3.741 | 1 | 4 | 83 |
GO:0006464 | cellular protein modification process | 7.32e-02 | 1.00e+00 | 3.723 | 1 | 4 | 84 |
GO:0009887 | organ morphogenesis | 7.48e-02 | 1.00e+00 | 3.689 | 1 | 5 | 86 |
GO:0045766 | positive regulation of angiogenesis | 7.65e-02 | 1.00e+00 | 3.656 | 1 | 2 | 88 |
GO:0016363 | nuclear matrix | 7.90e-02 | 1.00e+00 | 3.608 | 1 | 6 | 91 |
GO:0005200 | structural constituent of cytoskeleton | 7.90e-02 | 1.00e+00 | 3.608 | 1 | 6 | 91 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 7.99e-02 | 1.00e+00 | 3.592 | 1 | 1 | 92 |
GO:0071456 | cellular response to hypoxia | 7.99e-02 | 1.00e+00 | 3.592 | 1 | 3 | 92 |
GO:0051091 | positive regulation of sequence-specific DNA binding transcription factor activity | 7.99e-02 | 1.00e+00 | 3.592 | 1 | 7 | 92 |
GO:0051726 | regulation of cell cycle | 8.40e-02 | 1.00e+00 | 3.516 | 1 | 5 | 97 |
GO:0043235 | receptor complex | 8.57e-02 | 1.00e+00 | 3.486 | 1 | 2 | 99 |
GO:0001934 | positive regulation of protein phosphorylation | 8.98e-02 | 1.00e+00 | 3.415 | 1 | 5 | 104 |
GO:0005938 | cell cortex | 8.98e-02 | 1.00e+00 | 3.415 | 1 | 5 | 104 |
GO:0030496 | midbody | 9.31e-02 | 1.00e+00 | 3.361 | 1 | 2 | 108 |
GO:0097190 | apoptotic signaling pathway | 9.72e-02 | 1.00e+00 | 3.295 | 1 | 3 | 113 |
GO:0005635 | nuclear envelope | 9.72e-02 | 1.00e+00 | 3.295 | 1 | 5 | 113 |
GO:0048015 | phosphatidylinositol-mediated signaling | 9.81e-02 | 1.00e+00 | 3.283 | 1 | 2 | 114 |
GO:0051056 | regulation of small GTPase mediated signal transduction | 9.89e-02 | 1.00e+00 | 3.270 | 1 | 3 | 115 |
GO:0000209 | protein polyubiquitination | 9.97e-02 | 1.00e+00 | 3.258 | 1 | 3 | 116 |
GO:0007219 | Notch signaling pathway | 1.03e-01 | 1.00e+00 | 3.209 | 1 | 5 | 120 |
GO:0032496 | response to lipopolysaccharide | 1.04e-01 | 1.00e+00 | 3.197 | 1 | 4 | 121 |
GO:0006260 | DNA replication | 1.04e-01 | 1.00e+00 | 3.197 | 1 | 3 | 121 |
GO:0030036 | actin cytoskeleton organization | 1.05e-01 | 1.00e+00 | 3.173 | 1 | 3 | 123 |
GO:0030027 | lamellipodium | 1.07e-01 | 1.00e+00 | 3.150 | 1 | 7 | 125 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 1.09e-01 | 1.00e+00 | 3.116 | 1 | 11 | 128 |
GO:0045202 | synapse | 1.16e-01 | 1.00e+00 | 3.028 | 1 | 5 | 136 |
GO:0007507 | heart development | 1.18e-01 | 1.00e+00 | 2.997 | 1 | 7 | 139 |
GO:0010467 | gene expression | 1.20e-01 | 1.00e+00 | 1.730 | 2 | 45 | 669 |
GO:0000082 | G1/S transition of mitotic cell cycle | 1.26e-01 | 1.00e+00 | 2.896 | 1 | 3 | 149 |
GO:0042981 | regulation of apoptotic process | 1.27e-01 | 1.00e+00 | 2.887 | 1 | 4 | 150 |
GO:0045121 | membrane raft | 1.32e-01 | 1.00e+00 | 2.830 | 1 | 3 | 156 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 1.39e-01 | 1.00e+00 | 2.749 | 1 | 12 | 165 |
GO:0030424 | axon | 1.40e-01 | 1.00e+00 | 2.741 | 1 | 4 | 166 |
GO:0034641 | cellular nitrogen compound metabolic process | 1.44e-01 | 1.00e+00 | 2.698 | 1 | 2 | 171 |
GO:0031625 | ubiquitin protein ligase binding | 1.49e-01 | 1.00e+00 | 2.640 | 1 | 5 | 178 |
GO:0030168 | platelet activation | 1.70e-01 | 1.00e+00 | 2.436 | 1 | 6 | 205 |
GO:0019221 | cytokine-mediated signaling pathway | 1.82e-01 | 1.00e+00 | 2.328 | 1 | 8 | 221 |
GO:0016071 | mRNA metabolic process | 1.83e-01 | 1.00e+00 | 2.315 | 1 | 8 | 223 |
GO:0007399 | nervous system development | 1.89e-01 | 1.00e+00 | 2.264 | 1 | 6 | 231 |
GO:0043025 | neuronal cell body | 2.00e-01 | 1.00e+00 | 2.179 | 1 | 9 | 245 |
GO:0016070 | RNA metabolic process | 2.01e-01 | 1.00e+00 | 2.167 | 1 | 8 | 247 |
GO:0005874 | microtubule | 2.03e-01 | 1.00e+00 | 2.156 | 1 | 7 | 249 |
GO:0007283 | spermatogenesis | 2.12e-01 | 1.00e+00 | 2.082 | 1 | 3 | 262 |
GO:0048011 | neurotrophin TRK receptor signaling pathway | 2.17e-01 | 1.00e+00 | 2.044 | 1 | 7 | 269 |
GO:0007264 | small GTPase mediated signal transduction | 2.24e-01 | 1.00e+00 | 1.992 | 1 | 3 | 279 |
GO:0008270 | zinc ion binding | 2.25e-01 | 1.00e+00 | 1.154 | 2 | 27 | 997 |
GO:0005856 | cytoskeleton | 2.33e-01 | 1.00e+00 | 1.931 | 1 | 9 | 291 |
GO:0030154 | cell differentiation | 2.40e-01 | 1.00e+00 | 1.882 | 1 | 5 | 301 |
GO:0007411 | axon guidance | 2.52e-01 | 1.00e+00 | 1.798 | 1 | 5 | 319 |
GO:0003682 | chromatin binding | 2.58e-01 | 1.00e+00 | 1.762 | 1 | 19 | 327 |
GO:0008283 | cell proliferation | 2.59e-01 | 1.00e+00 | 1.758 | 1 | 14 | 328 |
GO:0030054 | cell junction | 2.64e-01 | 1.00e+00 | 1.723 | 1 | 5 | 336 |
GO:0003723 | RNA binding | 2.68e-01 | 1.00e+00 | 1.698 | 1 | 18 | 342 |
GO:0043565 | sequence-specific DNA binding | 2.71e-01 | 1.00e+00 | 1.681 | 1 | 11 | 346 |
GO:0005925 | focal adhesion | 2.84e-01 | 1.00e+00 | 1.600 | 1 | 9 | 366 |
GO:0009986 | cell surface | 3.08e-01 | 1.00e+00 | 1.465 | 1 | 9 | 402 |
GO:0045892 | negative regulation of transcription, DNA-templated | 3.15e-01 | 1.00e+00 | 1.426 | 1 | 24 | 413 |
GO:0007596 | blood coagulation | 3.41e-01 | 1.00e+00 | 1.286 | 1 | 11 | 455 |
GO:0070062 | extracellular vesicular exosome | 3.71e-01 | 1.00e+00 | 0.472 | 3 | 57 | 2400 |
GO:0005789 | endoplasmic reticulum membrane | 4.08e-01 | 1.00e+00 | 0.961 | 1 | 9 | 570 |
GO:0045087 | innate immune response | 4.22e-01 | 1.00e+00 | 0.896 | 1 | 15 | 596 |
GO:0005794 | Golgi apparatus | 4.30e-01 | 1.00e+00 | 0.863 | 1 | 9 | 610 |
GO:0005737 | cytoplasm | 4.53e-01 | 1.00e+00 | 0.236 | 4 | 124 | 3767 |
GO:0005887 | integral component of plasma membrane | 5.62e-01 | 1.00e+00 | 0.321 | 1 | 10 | 888 |
GO:0007165 | signal transduction | 5.70e-01 | 1.00e+00 | 0.291 | 1 | 13 | 907 |
GO:0005576 | extracellular region | 5.85e-01 | 1.00e+00 | 0.236 | 1 | 13 | 942 |
GO:0005615 | extracellular space | 5.91e-01 | 1.00e+00 | 0.213 | 1 | 20 | 957 |
GO:0005739 | mitochondrion | 6.06e-01 | 1.00e+00 | 0.153 | 1 | 23 | 998 |
GO:0044822 | poly(A) RNA binding | 6.28e-01 | 1.00e+00 | 0.071 | 1 | 50 | 1056 |
GO:0044281 | small molecule metabolic process | 6.80e-01 | 1.00e+00 | -0.126 | 1 | 20 | 1211 |
GO:0005886 | plasma membrane | 7.05e-01 | 1.00e+00 | -0.219 | 2 | 49 | 2582 |
GO:0016020 | membrane | 8.00e-01 | 1.00e+00 | -0.599 | 1 | 46 | 1681 |
GO:0016021 | integral component of membrane | 8.54e-01 | 1.00e+00 | -0.837 | 1 | 17 | 1982 |