int-snw-1875

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.826 2.08e-15 5.40e-04 3.66e-03
chia-screen-data-Fav-int-snw-1875 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
EP300 2033 22-2.2743.120415YesYes
[ E2F5 ] 1875 1-1.3812.82613--
FBXW2 26190 1-2.2922.82610Yes-
HES6 55502 8-2.5573.12011YesYes
YAP1 10413 94-4.2563.53853Yes-
TCL1A 8115 8-2.4573.12011YesYes
NFRKB 4798 48-3.1293.10823YesYes
TFDP2 7029 1-2.1502.82613Yes-
YY1 7528 24-2.5723.120114YesYes
HNRNPU 3192 76-2.8693.538139Yes-
POU5F1 5460 133-5.1483.538179YesYes
DDIT3 1649 60-2.8253.504343YesYes

Interactions (14)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
NFRKB 4798 YY1 7528 pp -- int.I2D: BioGrid
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
EP300 2033 HES6 55502 pp -- int.I2D: IntAct
DDIT3 1649 EP300 2033 pp -- int.Intact: MI:0915(physical association)
EP300 2033 HNRNPU 3192 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vitro, in vivo
NFRKB 4798 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
EP300 2033 FBXW2 26190 pp -- int.I2D: BioGrid
EP300 2033 YY1 7528 pp -- int.I2D: BioGrid, BCI, HPRD;
int.Transfac: -;
int.Ravasi: -;
int.HPRD: in vivo;
int.DIP: MI:0218(physical interaction)
E2F5 1875 EP300 2033 pp -- int.I2D: BCI, HPRD;
int.Ravasi: -;
int.HPRD: in vitro, in vivo, yeast 2-hybrid
E2F5 1875 TFDP2 7029 pp -- int.Transfac: -
EP300 2033 TCL1A 8115 pp -- int.I2D: INNATEDB
EP300 2033 YAP1 10413 pp -- int.I2D: BioGrid
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (216)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005667transcription factor complex2.55e-093.67e-055.365617175
GO:0008134transcription factor binding1.78e-082.57e-044.897618242
GO:0003677DNA binding3.70e-085.33e-043.1519491218
GO:0003700sequence-specific DNA binding transcription factor activity3.90e-075.63e-033.589739699
GO:0005654nucleoplasm7.43e-061.07e-012.9597641082
GO:0044212transcription regulatory region DNA binding8.17e-061.18e-014.839417168
GO:0042789mRNA transcription from RNA polymerase II promoter4.92e-057.10e-017.5312213
GO:0031011Ino80 complex5.74e-058.28e-017.4242614
GO:0006355regulation of transcription, DNA-templated6.91e-059.97e-012.855643997
GO:0006974cellular response to DNA damage stimulus2.31e-041.00e+004.57837151
GO:0045944positive regulation of transcription from RNA polymerase II promoter2.77e-041.00e+002.929541789
GO:0003714transcription corepressor activity3.75e-041.00e+004.340311178
GO:0006367transcription initiation from RNA polymerase II promoter4.13e-041.00e+004.293322184
GO:0003712transcription cofactor activity5.89e-041.00e+005.7722844
GO:0060795cell fate commitment involved in formation of primary germ layer8.32e-041.00e+0010.231111
GO:0060177regulation of angiotensin metabolic process8.32e-041.00e+0010.231111
GO:2000016negative regulation of determination of dorsal identity8.32e-041.00e+0010.231111
GO:1901985positive regulation of protein acetylation8.32e-041.00e+0010.231111
GO:0043969histone H2B acetylation8.32e-041.00e+0010.231111
GO:2000629negative regulation of miRNA metabolic process8.32e-041.00e+0010.231111
GO:0090308regulation of methylation-dependent chromatin silencing8.32e-041.00e+0010.231111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway8.32e-041.00e+0010.231111
GO:0060965negative regulation of gene silencing by miRNA8.32e-041.00e+0010.231111
GO:0003713transcription coactivator activity8.64e-041.00e+003.927324237
GO:0034696response to prostaglandin F1.66e-031.00e+009.231112
GO:0060242contact inhibition1.66e-031.00e+009.231112
GO:0014737positive regulation of muscle atrophy1.66e-031.00e+009.231112
GO:0006403RNA localization1.66e-031.00e+009.231112
GO:0009786regulation of asymmetric cell division1.66e-031.00e+009.231112
GO:0090043regulation of tubulin deacetylation1.66e-031.00e+009.231122
GO:0035984cellular response to trichostatin A1.66e-031.00e+009.231112
GO:0071389cellular response to mineralocorticoid stimulus1.66e-031.00e+009.231112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.66e-031.00e+009.231112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.66e-031.00e+009.231112
GO:0010467gene expression1.68e-031.00e+002.845445669
GO:0009887organ morphogenesis2.23e-031.00e+004.8052586
GO:0018076N-terminal peptidyl-lysine acetylation2.49e-031.00e+008.646113
GO:0060913cardiac cell fate determination2.49e-031.00e+008.646113
GO:0003130BMP signaling pathway involved in heart induction2.49e-031.00e+008.646113
GO:0010560positive regulation of glycoprotein biosynthetic process2.49e-031.00e+008.646113
GO:0051726regulation of cell cycle2.83e-031.00e+004.6312597
GO:0097157pre-mRNA intronic binding3.32e-031.00e+008.231114
GO:0018393internal peptidyl-lysine acetylation3.32e-031.00e+008.231114
GO:0000278mitotic cell cycle3.62e-031.00e+003.205315391
GO:0005515protein binding4.10e-031.00e+000.997101986024
GO:0001714endodermal cell fate specification4.15e-031.00e+007.909115
GO:0065004protein-DNA complex assembly4.15e-031.00e+007.909115
GO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor4.15e-031.00e+007.909115
GO:0043620regulation of DNA-templated transcription in response to stress4.15e-031.00e+007.909115
GO:0070934CRD-mediated mRNA stabilization4.15e-031.00e+007.909125
GO:0060298positive regulation of sarcomere organization4.15e-031.00e+007.909115
GO:0032025response to cobalt ion4.15e-031.00e+007.909115
GO:0007219Notch signaling pathway4.29e-031.00e+004.32425120
GO:0006351transcription, DNA-templated4.36e-031.00e+002.0555571446
GO:0007179transforming growth factor beta receptor signaling pathway4.87e-031.00e+004.231211128
GO:0070937CRD-mediated mRNA stability complex4.98e-031.00e+007.646136
GO:0006475internal protein amino acid acetylation5.81e-031.00e+007.424117
GO:0001955blood vessel maturation6.64e-031.00e+007.231118
GO:0060765regulation of androgen receptor signaling pathway7.47e-031.00e+007.061119
GO:0010225response to UV-C7.47e-031.00e+007.061129
GO:0006983ER overload response7.47e-031.00e+007.061119
GO:0035259glucocorticoid receptor binding7.47e-031.00e+007.061119
GO:0045793positive regulation of cell size7.47e-031.00e+007.061129
GO:0000400four-way junction DNA binding7.47e-031.00e+007.061119
GO:0035413positive regulation of catenin import into nucleus8.29e-031.00e+006.9091210
GO:0016407acetyltransferase activity8.29e-031.00e+006.9091210
GO:0043923positive regulation by host of viral transcription9.12e-031.00e+006.7721111
GO:0033160positive regulation of protein import into nucleus, translocation9.12e-031.00e+006.7721311
GO:0045662negative regulation of myoblast differentiation9.12e-031.00e+006.7721311
GO:0042975peroxisome proliferator activated receptor binding9.12e-031.00e+006.7721111
GO:0045120pronucleus9.12e-031.00e+006.7721211
GO:0060391positive regulation of SMAD protein import into nucleus9.12e-031.00e+006.7721411
GO:0035198miRNA binding9.94e-031.00e+006.6461112
GO:0071480cellular response to gamma radiation1.08e-021.00e+006.5311113
GO:0051019mitogen-activated protein kinase binding1.08e-021.00e+006.5311213
GO:0016746transferase activity, transferring acyl groups1.08e-021.00e+006.5311113
GO:0070542response to fatty acid1.16e-021.00e+006.4241114
GO:0032993protein-DNA complex1.16e-021.00e+006.4241214
GO:0001824blastocyst development1.24e-021.00e+006.3241215
GO:1990090cellular response to nerve growth factor stimulus1.24e-021.00e+006.3241115
GO:0051276chromosome organization1.32e-021.00e+006.2311216
GO:0048593camera-type eye morphogenesis1.32e-021.00e+006.2311116
GO:0005634nucleus1.33e-021.00e+001.07781594559
GO:0045773positive regulation of axon extension1.49e-021.00e+006.0611118
GO:0033613activating transcription factor binding1.49e-021.00e+006.0611318
GO:0007399nervous system development1.52e-021.00e+003.37926231
GO:0035257nuclear hormone receptor binding1.57e-021.00e+005.9831119
GO:0071549cellular response to dexamethasone stimulus1.65e-021.00e+005.9091320
GO:0010942positive regulation of cell death1.65e-021.00e+005.9091120
GO:0032757positive regulation of interleukin-8 production1.65e-021.00e+005.9091120
GO:0000123histone acetyltransferase complex1.73e-021.00e+005.8391621
GO:0032967positive regulation of collagen biosynthetic process1.73e-021.00e+005.8391321
GO:0045862positive regulation of proteolysis1.73e-021.00e+005.8391221
GO:0003823antigen binding1.82e-021.00e+005.7721222
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721222
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress1.90e-021.00e+005.7081123
GO:0006357regulation of transcription from RNA polymerase II promoter1.95e-021.00e+003.187223264
GO:0043388positive regulation of DNA binding1.98e-021.00e+005.6461224
GO:0043425bHLH transcription factor binding1.98e-021.00e+005.6461124
GO:0051059NF-kappaB binding2.06e-021.00e+005.5871325
GO:0031519PcG protein complex2.06e-021.00e+005.5871125
GO:0035329hippo signaling2.14e-021.00e+005.5311526
GO:0051209release of sequestered calcium ion into cytosol2.14e-021.00e+005.5311126
GO:0048565digestive tract development2.14e-021.00e+005.5311226
GO:0030030cell projection organization2.14e-021.00e+005.5311126
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.14e-021.00e+005.5311126
GO:0034612response to tumor necrosis factor2.22e-021.00e+005.4761227
GO:0043967histone H4 acetylation2.22e-021.00e+005.4761127
GO:0050714positive regulation of protein secretion2.31e-021.00e+005.4241328
GO:0034644cellular response to UV2.47e-021.00e+005.3241130
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator2.47e-021.00e+005.3241130
GO:0030154cell differentiation2.50e-021.00e+002.99825301
GO:0042594response to starvation2.55e-021.00e+005.2771431
GO:0043491protein kinase B signaling2.63e-021.00e+005.2311232
GO:1903507negative regulation of nucleic acid-templated transcription2.63e-021.00e+005.2311232
GO:0071333cellular response to glucose stimulus2.71e-021.00e+005.1871133
GO:0001756somitogenesis2.71e-021.00e+005.1871133
GO:0001102RNA polymerase II activating transcription factor binding2.96e-021.00e+005.0611136
GO:0032092positive regulation of protein binding3.12e-021.00e+004.9831238
GO:0031490chromatin DNA binding3.12e-021.00e+004.9831238
GO:0050681androgen receptor binding3.12e-021.00e+004.9831138
GO:0003723RNA binding3.16e-021.00e+002.813218342
GO:0043565sequence-specific DNA binding3.23e-021.00e+002.796211346
GO:0035019somatic stem cell maintenance3.28e-021.00e+004.9091640
GO:0007519skeletal muscle tissue development3.28e-021.00e+004.9091240
GO:0046332SMAD binding3.28e-021.00e+004.9091240
GO:0071320cellular response to cAMP3.28e-021.00e+004.9091140
GO:0070301cellular response to hydrogen peroxide3.36e-021.00e+004.8741241
GO:0004402histone acetyltransferase activity3.52e-021.00e+004.8051643
GO:0045727positive regulation of translation3.60e-021.00e+004.7721244
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding3.60e-021.00e+004.7721444
GO:0043966histone H3 acetylation3.68e-021.00e+004.7391545
GO:0001047core promoter binding3.68e-021.00e+004.7391545
GO:0043525positive regulation of neuron apoptotic process3.76e-021.00e+004.7081446
GO:0019827stem cell maintenance3.84e-021.00e+004.6771747
GO:0035690cellular response to drug4.00e-021.00e+004.6161349
GO:0006986response to unfolded protein4.08e-021.00e+004.5871450
GO:0034976response to endoplasmic reticulum stress4.16e-021.00e+004.5591251
GO:0045454cell redox homeostasis4.16e-021.00e+004.5591151
GO:0009611response to wounding4.24e-021.00e+004.5311552
GO:0007623circadian rhythm4.32e-021.00e+004.5031153
GO:0071300cellular response to retinoic acid4.48e-021.00e+004.4501155
GO:0051592response to calcium ion4.48e-021.00e+004.4501155
GO:0000724double-strand break repair via homologous recombination4.48e-021.00e+004.4501255
GO:0002039p53 binding4.48e-021.00e+004.4501455
GO:0043627response to estrogen4.56e-021.00e+004.4241556
GO:0006366transcription from RNA polymerase II promoter4.58e-021.00e+002.520230419
GO:0006396RNA processing4.80e-021.00e+004.3481559
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription4.80e-021.00e+004.3481559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity4.80e-021.00e+004.3481659
GO:0008013beta-catenin binding4.88e-021.00e+004.3241960
GO:0032481positive regulation of type I interferon production4.96e-021.00e+004.3001661
GO:0006987activation of signaling protein activity involved in unfolded protein response4.96e-021.00e+004.3001261
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process5.12e-021.00e+004.2541463
GO:0006310DNA recombination5.28e-021.00e+004.2091765
GO:0010468regulation of gene expression5.52e-021.00e+004.1441268
GO:0030324lung development5.83e-021.00e+004.0611172
GO:0000785chromatin5.91e-021.00e+004.0411673
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.99e-021.00e+004.0221474
GO:0002020protease binding5.99e-021.00e+004.0221674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.07e-021.00e+004.0021175
GO:0001889liver development6.22e-021.00e+003.9641377
GO:0071013catalytic step 2 spliceosome6.30e-021.00e+003.9461778
GO:0030968endoplasmic reticulum unfolded protein response6.38e-021.00e+003.9271279
GO:0009653anatomical structure morphogenesis6.69e-021.00e+003.8561283
GO:0009952anterior/posterior pattern specification6.69e-021.00e+003.8561483
GO:0006464cellular protein modification process6.77e-021.00e+003.8391484
GO:0090090negative regulation of canonical Wnt signaling pathway6.93e-021.00e+003.8051886
GO:0045471response to ethanol6.93e-021.00e+003.8051386
GO:0016363nuclear matrix7.32e-021.00e+003.7231691
GO:0001649osteoblast differentiation7.39e-021.00e+003.7081592
GO:0071456cellular response to hypoxia7.39e-021.00e+003.7081392
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity7.39e-021.00e+003.7081792
GO:0005770late endosome7.47e-021.00e+003.6921293
GO:0000122negative regulation of transcription from RNA polymerase II promoter7.92e-021.00e+002.076237570
GO:0005938cell cortex8.32e-021.00e+003.53115104
GO:0001934positive regulation of protein phosphorylation8.32e-021.00e+003.53115104
GO:0030529ribonucleoprotein complex8.93e-021.00e+003.42415112
GO:0046983protein dimerization activity9.39e-021.00e+003.34815118
GO:0006325chromatin organization9.39e-021.00e+003.348112118
GO:0007050cell cycle arrest9.85e-021.00e+003.27715124
GO:0000086G2/M transition of mitotic cell cycle1.08e-011.00e+003.14414136
GO:0016055Wnt signaling pathway1.09e-011.00e+003.12314138
GO:0007507heart development1.10e-011.00e+003.11217139
GO:0001666response to hypoxia1.17e-011.00e+003.01217149
GO:0000398mRNA splicing, via spliceosome1.28e-011.00e+002.874115164
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.29e-011.00e+002.865112165
GO:0031625ubiquitin protein ligase binding1.38e-011.00e+002.75515178
GO:0019904protein domain specific binding1.39e-011.00e+002.74718179
GO:0032403protein complex binding1.42e-011.00e+002.71516183
GO:0008380RNA splicing1.74e-011.00e+002.398122228
GO:0005737cytoplasm1.81e-011.00e+000.67451243767
GO:0004842ubiquitin-protein transferase activity1.93e-011.00e+002.23715255
GO:0006281DNA repair1.97e-011.00e+002.203114261
GO:0007283spermatogenesis1.98e-011.00e+002.19813262
GO:0008270zinc ion binding1.99e-011.00e+001.270227997
GO:0006954inflammatory response2.08e-011.00e+002.11716277
GO:0044822poly(A) RNA binding2.18e-011.00e+001.1872501056
GO:0016567protein ubiquitination2.20e-011.00e+002.02714295
GO:0007275multicellular organismal development2.34e-011.00e+001.92717316
GO:0003682chromatin binding2.41e-011.00e+001.878119327
GO:0008283cell proliferation2.41e-011.00e+001.874114328
GO:0006508proteolysis2.73e-011.00e+001.66916378
GO:0046982protein heterodimerization activity2.74e-011.00e+001.66118380
GO:0009986cell surface2.88e-011.00e+001.58019402
GO:0045892negative regulation of transcription, DNA-templated2.94e-011.00e+001.541124413
GO:0044267cellular protein metabolic process3.30e-011.00e+001.342120474
GO:0045893positive regulation of transcription, DNA-templated3.33e-011.00e+001.330124478
GO:0005829cytosol3.45e-011.00e+000.5313862496
GO:0016032viral process3.64e-011.00e+001.170126534
GO:0006915apoptotic process3.76e-011.00e+001.115112555
GO:0005783endoplasmic reticulum3.76e-011.00e+001.112113556
GO:0045087innate immune response3.97e-011.00e+001.012115596
GO:0005730nucleolus4.04e-011.00e+000.5512661641
GO:0005524ATP binding6.78e-011.00e+00-0.1111311298
GO:0016020membrane7.74e-011.00e+00-0.4841461681