Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
chia-screen-data-Fav | 2.870 | 6.90e-16 | 3.15e-04 | 2.50e-03 |
Gene Symbol | Entrez Gene ID | Frequency | chia-screen-data-Fav gene score | Best subnetwork score | Degree | Chia-Hits Primary | Chia-Hits Secondary |
---|---|---|---|---|---|---|---|
MED19 | 219541 | 30 | -2.657 | 3.449 | 115 | Yes | - |
PSMD2 | 5708 | 47 | -4.172 | 3.157 | 386 | Yes | Yes |
PHB2 | 11331 | 5 | -2.236 | 2.994 | 140 | Yes | - |
LUC7L3 | 51747 | 33 | -3.523 | 3.449 | 18 | Yes | - |
PHB | 5245 | 15 | -2.743 | 3.004 | 127 | Yes | Yes |
YAP1 | 10413 | 94 | -4.256 | 3.538 | 53 | Yes | - |
POU5F1 | 5460 | 133 | -5.148 | 3.538 | 179 | Yes | Yes |
HSPD1 | 3329 | 3 | -1.852 | 2.870 | 286 | - | - |
HNRNPU | 3192 | 76 | -2.869 | 3.538 | 139 | Yes | - |
HAGH | 3029 | 1 | -1.562 | 2.870 | 32 | - | - |
[ ADSSL1 ] | 122622 | 1 | -1.224 | 2.870 | 36 | - | - |
SON | 6651 | 9 | -3.844 | 3.108 | 9 | Yes | Yes |
CDK12 | 51755 | 6 | -2.714 | 2.944 | 15 | Yes | - |
DDIT3 | 1649 | 60 | -2.825 | 3.504 | 343 | Yes | Yes |
SF3A1 | 10291 | 4 | -2.787 | 3.129 | 43 | Yes | Yes |
PRPF40A | 55660 | 2 | -1.511 | 3.108 | 199 | - | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
SF3A1 | 10291 | PRPF40A | 55660 | pp | -- | int.I2D: BioGrid, Pawson1; int.Mint: MI:0915(physical association) |
PRPF40A | 55660 | ADSSL1 | 122622 | pp | -- | int.I2D: BioGrid_Yeast, MINT_Yeast, IntAct_Yeast |
HSPD1 | 3329 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
HNRNPU | 3192 | YAP1 | 10413 | pp | -- | int.I2D: HPRD; int.HPRD: in vitro, in vivo |
PSMD2 | 5708 | ADSSL1 | 122622 | pp | -- | int.I2D: BioGrid_Yeast |
SON | 6651 | PRPF40A | 55660 | pp | -- | int.I2D: BIND, MINT, HPRD; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
HSPD1 | 3329 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
HAGH | 3029 | ADSSL1 | 122622 | pp | -- | int.I2D: YeastLow |
PHB | 5245 | PHB2 | 11331 | pp | -- | int.I2D: BioGrid, BioGrid_Yeast, IntAct_Yeast |
HSPD1 | 3329 | ADSSL1 | 122622 | pp | -- | int.I2D: IntAct_Yeast |
HNRNPU | 3192 | PRPF40A | 55660 | pp | -- | int.I2D: BioGrid, Pawson1 |
HNRNPU | 3192 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
PHB2 | 11331 | ADSSL1 | 122622 | pp | -- | int.I2D: YeastMedium |
LUC7L3 | 51747 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
PHB | 5245 | ADSSL1 | 122622 | pp | -- | int.I2D: YeastMedium |
DDIT3 | 1649 | HSPD1 | 3329 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
DDIT3 | 1649 | HNRNPU | 3192 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
CDK12 | 51755 | PRPF40A | 55660 | pp | -- | int.I2D: BioGrid, BIND, MINT, Pawson1, HPRD; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
PSMD2 | 5708 | PHB2 | 11331 | pp | -- | int.I2D: IntAct_Yeast |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0008380 | RNA splicing | 1.03e-07 | 1.48e-03 | 4.568 | 6 | 22 | 228 |
GO:0006397 | mRNA processing | 2.39e-05 | 3.45e-01 | 4.494 | 4 | 10 | 160 |
GO:0044212 | transcription regulatory region DNA binding | 2.90e-05 | 4.18e-01 | 4.424 | 4 | 17 | 168 |
GO:0016607 | nuclear speck | 3.18e-05 | 4.58e-01 | 4.390 | 4 | 12 | 172 |
GO:0044822 | poly(A) RNA binding | 7.02e-05 | 1.00e+00 | 2.579 | 7 | 50 | 1056 |
GO:0005654 | nucleoplasm | 8.21e-05 | 1.00e+00 | 2.544 | 7 | 64 | 1082 |
GO:0042789 | mRNA transcription from RNA polymerase II promoter | 8.94e-05 | 1.00e+00 | 7.116 | 2 | 2 | 13 |
GO:0005634 | nucleus | 4.55e-04 | 1.00e+00 | 1.247 | 12 | 159 | 4559 |
GO:0042594 | response to starvation | 5.27e-04 | 1.00e+00 | 5.862 | 2 | 4 | 31 |
GO:0060795 | cell fate commitment involved in formation of primary germ layer | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 1 |
GO:0002842 | positive regulation of T cell mediated immune response to tumor cell | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 1 |
GO:2000016 | negative regulation of determination of dorsal identity | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 1 |
GO:0048291 | isotype switching to IgG isotypes | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 1 |
GO:0090308 | regulation of methylation-dependent chromatin silencing | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 1 |
GO:0090081 | regulation of heart induction by regulation of canonical Wnt signaling pathway | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 1 |
GO:0060965 | negative regulation of gene silencing by miRNA | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 1 |
GO:0002368 | B cell cytokine production | 1.11e-03 | 1.00e+00 | 9.816 | 1 | 1 | 1 |
GO:0006986 | response to unfolded protein | 1.37e-03 | 1.00e+00 | 5.172 | 2 | 4 | 50 |
GO:0005515 | protein binding | 1.51e-03 | 1.00e+00 | 0.960 | 13 | 198 | 6024 |
GO:0060242 | contact inhibition | 2.22e-03 | 1.00e+00 | 8.816 | 1 | 1 | 2 |
GO:0005684 | U2-type spliceosomal complex | 2.22e-03 | 1.00e+00 | 8.816 | 1 | 1 | 2 |
GO:0004019 | adenylosuccinate synthase activity | 2.22e-03 | 1.00e+00 | 8.816 | 1 | 1 | 2 |
GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain | 2.22e-03 | 1.00e+00 | 8.816 | 1 | 1 | 2 |
GO:0009786 | regulation of asymmetric cell division | 2.22e-03 | 1.00e+00 | 8.816 | 1 | 1 | 2 |
GO:0002944 | cyclin K-CDK12 complex | 2.22e-03 | 1.00e+00 | 8.816 | 1 | 1 | 2 |
GO:0004416 | hydroxyacylglutathione hydrolase activity | 2.22e-03 | 1.00e+00 | 8.816 | 1 | 1 | 2 |
GO:0044324 | regulation of transcription involved in anterior/posterior axis specification | 2.22e-03 | 1.00e+00 | 8.816 | 1 | 1 | 2 |
GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 2.22e-03 | 1.00e+00 | 8.816 | 1 | 1 | 2 |
GO:0005743 | mitochondrial inner membrane | 3.26e-03 | 1.00e+00 | 3.287 | 3 | 6 | 277 |
GO:0071013 | catalytic step 2 spliceosome | 3.30e-03 | 1.00e+00 | 4.531 | 2 | 7 | 78 |
GO:0006458 | 'de novo' protein folding | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 3 |
GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 3 |
GO:0046040 | IMP metabolic process | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 3 |
GO:0044208 | 'de novo' AMP biosynthetic process | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 3 |
GO:0060913 | cardiac cell fate determination | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 3 |
GO:0003130 | BMP signaling pathway involved in heart induction | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 3 |
GO:0030135 | coated vesicle | 3.32e-03 | 1.00e+00 | 8.231 | 1 | 1 | 3 |
GO:0006167 | AMP biosynthetic process | 4.43e-03 | 1.00e+00 | 7.816 | 1 | 1 | 4 |
GO:0016363 | nuclear matrix | 4.46e-03 | 1.00e+00 | 4.308 | 2 | 6 | 91 |
GO:0001649 | osteoblast differentiation | 4.56e-03 | 1.00e+00 | 4.293 | 2 | 5 | 92 |
GO:0051726 | regulation of cell cycle | 5.05e-03 | 1.00e+00 | 4.216 | 2 | 5 | 97 |
GO:0010467 | gene expression | 5.34e-03 | 1.00e+00 | 2.430 | 4 | 45 | 669 |
GO:0001714 | endodermal cell fate specification | 5.54e-03 | 1.00e+00 | 7.494 | 1 | 1 | 5 |
GO:0046696 | lipopolysaccharide receptor complex | 5.54e-03 | 1.00e+00 | 7.494 | 1 | 1 | 5 |
GO:0043620 | regulation of DNA-templated transcription in response to stress | 5.54e-03 | 1.00e+00 | 7.494 | 1 | 1 | 5 |
GO:0070934 | CRD-mediated mRNA stabilization | 5.54e-03 | 1.00e+00 | 7.494 | 1 | 2 | 5 |
GO:0033600 | negative regulation of mammary gland epithelial cell proliferation | 5.54e-03 | 1.00e+00 | 7.494 | 1 | 1 | 5 |
GO:0000389 | mRNA 3'-splice site recognition | 5.54e-03 | 1.00e+00 | 7.494 | 1 | 2 | 5 |
GO:0043405 | regulation of MAP kinase activity | 5.54e-03 | 1.00e+00 | 7.494 | 1 | 1 | 5 |
GO:0003723 | RNA binding | 5.88e-03 | 1.00e+00 | 2.983 | 3 | 18 | 342 |
GO:0050847 | progesterone receptor signaling pathway | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 2 | 6 |
GO:0003688 | DNA replication origin binding | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 6 |
GO:0006531 | aspartate metabolic process | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 6 |
GO:0060744 | mammary gland branching involved in thelarche | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 2 | 6 |
GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 6 |
GO:0050733 | RS domain binding | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 6 |
GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 1 | 6 |
GO:0070937 | CRD-mediated mRNA stability complex | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 3 | 6 |
GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis | 6.64e-03 | 1.00e+00 | 7.231 | 1 | 2 | 6 |
GO:0071354 | cellular response to interleukin-6 | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 2 | 7 |
GO:0003677 | DNA binding | 8.45e-03 | 1.00e+00 | 1.888 | 5 | 49 | 1218 |
GO:0014850 | response to muscle activity | 8.84e-03 | 1.00e+00 | 6.816 | 1 | 1 | 8 |
GO:0001955 | blood vessel maturation | 8.84e-03 | 1.00e+00 | 6.816 | 1 | 1 | 8 |
GO:0051604 | protein maturation | 8.84e-03 | 1.00e+00 | 6.816 | 1 | 2 | 8 |
GO:0045892 | negative regulation of transcription, DNA-templated | 9.89e-03 | 1.00e+00 | 2.711 | 3 | 24 | 413 |
GO:0006983 | ER overload response | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 9 |
GO:0010944 | negative regulation of transcription by competitive promoter binding | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 9 |
GO:0043066 | negative regulation of apoptotic process | 1.06e-02 | 1.00e+00 | 2.673 | 3 | 16 | 424 |
GO:0035413 | positive regulation of catenin import into nucleus | 1.10e-02 | 1.00e+00 | 6.494 | 1 | 2 | 10 |
GO:0042301 | phosphate ion binding | 1.10e-02 | 1.00e+00 | 6.494 | 1 | 1 | 10 |
GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 1.10e-02 | 1.00e+00 | 6.494 | 1 | 2 | 10 |
GO:0043032 | positive regulation of macrophage activation | 1.10e-02 | 1.00e+00 | 6.494 | 1 | 1 | 10 |
GO:0006750 | glutathione biosynthetic process | 1.10e-02 | 1.00e+00 | 6.494 | 1 | 1 | 10 |
GO:0042981 | regulation of apoptotic process | 1.17e-02 | 1.00e+00 | 3.587 | 2 | 4 | 150 |
GO:0006974 | cellular response to DNA damage stimulus | 1.19e-02 | 1.00e+00 | 3.578 | 2 | 7 | 151 |
GO:0032727 | positive regulation of interferon-alpha production | 1.21e-02 | 1.00e+00 | 6.357 | 1 | 1 | 11 |
GO:0071257 | cellular response to electrical stimulus | 1.21e-02 | 1.00e+00 | 6.357 | 1 | 2 | 11 |
GO:0045662 | negative regulation of myoblast differentiation | 1.21e-02 | 1.00e+00 | 6.357 | 1 | 3 | 11 |
GO:0060391 | positive regulation of SMAD protein import into nucleus | 1.21e-02 | 1.00e+00 | 6.357 | 1 | 4 | 11 |
GO:0009168 | purine ribonucleoside monophosphate biosynthetic process | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 1 | 12 |
GO:0005838 | proteasome regulatory particle | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 1 | 12 |
GO:0035198 | miRNA binding | 1.32e-02 | 1.00e+00 | 6.231 | 1 | 1 | 12 |
GO:0000398 | mRNA splicing, via spliceosome | 1.39e-02 | 1.00e+00 | 3.459 | 2 | 15 | 164 |
GO:0060766 | negative regulation of androgen receptor signaling pathway | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 3 | 13 |
GO:0071480 | cellular response to gamma radiation | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 1 | 13 |
GO:0030234 | enzyme regulator activity | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 2 | 13 |
GO:0001530 | lipopolysaccharide binding | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 1 | 13 |
GO:0051131 | chaperone-mediated protein complex assembly | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 1 | 13 |
GO:0005685 | U1 snRNP | 1.54e-02 | 1.00e+00 | 6.009 | 1 | 1 | 14 |
GO:0032465 | regulation of cytokinesis | 1.54e-02 | 1.00e+00 | 6.009 | 1 | 1 | 14 |
GO:0003714 | transcription corepressor activity | 1.62e-02 | 1.00e+00 | 3.340 | 2 | 11 | 178 |
GO:0001824 | blastocyst development | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 2 | 15 |
GO:0060749 | mammary gland alveolus development | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 2 | 15 |
GO:0042026 | protein refolding | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 15 |
GO:0006376 | mRNA splice site selection | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 1 | 15 |
GO:0042176 | regulation of protein catabolic process | 1.76e-02 | 1.00e+00 | 5.816 | 1 | 2 | 16 |
GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity | 1.76e-02 | 1.00e+00 | 5.816 | 1 | 1 | 16 |
GO:0006541 | glutamine metabolic process | 1.87e-02 | 1.00e+00 | 5.729 | 1 | 2 | 17 |
GO:0050870 | positive regulation of T cell activation | 1.87e-02 | 1.00e+00 | 5.729 | 1 | 1 | 17 |
GO:0022624 | proteasome accessory complex | 1.87e-02 | 1.00e+00 | 5.729 | 1 | 1 | 17 |
GO:0030332 | cyclin binding | 1.98e-02 | 1.00e+00 | 5.646 | 1 | 1 | 18 |
GO:0070064 | proline-rich region binding | 1.98e-02 | 1.00e+00 | 5.646 | 1 | 1 | 18 |
GO:0032733 | positive regulation of interleukin-10 production | 2.09e-02 | 1.00e+00 | 5.568 | 1 | 2 | 19 |
GO:0006355 | regulation of transcription, DNA-templated | 2.11e-02 | 1.00e+00 | 1.855 | 4 | 43 | 997 |
GO:0032757 | positive regulation of interleukin-8 production | 2.20e-02 | 1.00e+00 | 5.494 | 1 | 1 | 20 |
GO:0042100 | B cell proliferation | 2.31e-02 | 1.00e+00 | 5.424 | 1 | 1 | 21 |
GO:0016575 | histone deacetylation | 2.31e-02 | 1.00e+00 | 5.424 | 1 | 3 | 21 |
GO:0043484 | regulation of RNA splicing | 2.41e-02 | 1.00e+00 | 5.357 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 2.41e-02 | 1.00e+00 | 5.357 | 1 | 2 | 22 |
GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 2.52e-02 | 1.00e+00 | 5.293 | 1 | 1 | 23 |
GO:0005759 | mitochondrial matrix | 2.58e-02 | 1.00e+00 | 2.983 | 2 | 4 | 228 |
GO:0042113 | B cell activation | 2.74e-02 | 1.00e+00 | 5.172 | 1 | 2 | 25 |
GO:0032735 | positive regulation of interleukin-12 production | 2.74e-02 | 1.00e+00 | 5.172 | 1 | 2 | 25 |
GO:0005730 | nucleolus | 2.83e-02 | 1.00e+00 | 1.458 | 5 | 66 | 1641 |
GO:0035329 | hippo signaling | 2.85e-02 | 1.00e+00 | 5.116 | 1 | 5 | 26 |
GO:0051209 | release of sequestered calcium ion into cytosol | 2.85e-02 | 1.00e+00 | 5.116 | 1 | 1 | 26 |
GO:0008134 | transcription factor binding | 2.88e-02 | 1.00e+00 | 2.897 | 2 | 18 | 242 |
GO:0030331 | estrogen receptor binding | 2.96e-02 | 1.00e+00 | 5.061 | 1 | 2 | 27 |
GO:0071897 | DNA biosynthetic process | 3.06e-02 | 1.00e+00 | 5.009 | 1 | 1 | 28 |
GO:0016020 | membrane | 3.10e-02 | 1.00e+00 | 1.423 | 5 | 46 | 1681 |
GO:0006144 | purine nucleobase metabolic process | 3.28e-02 | 1.00e+00 | 4.909 | 1 | 1 | 30 |
GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | 3.39e-02 | 1.00e+00 | 4.862 | 1 | 1 | 31 |
GO:0002376 | immune system process | 3.49e-02 | 1.00e+00 | 4.816 | 1 | 3 | 32 |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 3.49e-02 | 1.00e+00 | 4.816 | 1 | 2 | 32 |
GO:0001104 | RNA polymerase II transcription cofactor activity | 3.60e-02 | 1.00e+00 | 4.772 | 1 | 8 | 33 |
GO:0016592 | mediator complex | 3.81e-02 | 1.00e+00 | 4.687 | 1 | 10 | 35 |
GO:0032755 | positive regulation of interleukin-6 production | 3.92e-02 | 1.00e+00 | 4.646 | 1 | 2 | 36 |
GO:0043234 | protein complex | 4.14e-02 | 1.00e+00 | 2.612 | 2 | 11 | 295 |
GO:0032729 | positive regulation of interferon-gamma production | 4.24e-02 | 1.00e+00 | 4.531 | 1 | 1 | 39 |
GO:0035019 | somatic stem cell maintenance | 4.35e-02 | 1.00e+00 | 4.494 | 1 | 6 | 40 |
GO:0005829 | cytosol | 4.44e-02 | 1.00e+00 | 1.116 | 6 | 86 | 2496 |
GO:0042110 | T cell activation | 4.56e-02 | 1.00e+00 | 4.424 | 1 | 1 | 42 |
GO:0043525 | positive regulation of neuron apoptotic process | 4.99e-02 | 1.00e+00 | 4.293 | 1 | 4 | 46 |
GO:0035690 | cellular response to drug | 5.30e-02 | 1.00e+00 | 4.201 | 1 | 3 | 49 |
GO:0006521 | regulation of cellular amino acid metabolic process | 5.41e-02 | 1.00e+00 | 4.172 | 1 | 1 | 50 |
GO:0005905 | coated pit | 5.41e-02 | 1.00e+00 | 4.172 | 1 | 6 | 50 |
GO:0034976 | response to endoplasmic reticulum stress | 5.51e-02 | 1.00e+00 | 4.144 | 1 | 2 | 51 |
GO:0045454 | cell redox homeostasis | 5.51e-02 | 1.00e+00 | 4.144 | 1 | 1 | 51 |
GO:0000910 | cytokinesis | 5.51e-02 | 1.00e+00 | 4.144 | 1 | 2 | 51 |
GO:0043565 | sequence-specific DNA binding | 5.52e-02 | 1.00e+00 | 2.381 | 2 | 11 | 346 |
GO:0003725 | double-stranded RNA binding | 5.62e-02 | 1.00e+00 | 4.116 | 1 | 1 | 52 |
GO:0000226 | microtubule cytoskeleton organization | 5.62e-02 | 1.00e+00 | 4.116 | 1 | 2 | 52 |
GO:0009611 | response to wounding | 5.62e-02 | 1.00e+00 | 4.116 | 1 | 5 | 52 |
GO:0002039 | p53 binding | 5.93e-02 | 1.00e+00 | 4.035 | 1 | 4 | 55 |
GO:0000502 | proteasome complex | 6.25e-02 | 1.00e+00 | 3.958 | 1 | 3 | 58 |
GO:0006396 | RNA processing | 6.35e-02 | 1.00e+00 | 3.933 | 1 | 5 | 59 |
GO:0051087 | chaperone binding | 6.35e-02 | 1.00e+00 | 3.933 | 1 | 3 | 59 |
GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | 6.35e-02 | 1.00e+00 | 3.933 | 1 | 6 | 59 |
GO:0006987 | activation of signaling protein activity involved in unfolded protein response | 6.56e-02 | 1.00e+00 | 3.885 | 1 | 2 | 61 |
GO:0030141 | secretory granule | 6.66e-02 | 1.00e+00 | 3.862 | 1 | 4 | 62 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 6.87e-02 | 1.00e+00 | 3.816 | 1 | 1 | 64 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 6.98e-02 | 1.00e+00 | 3.794 | 1 | 2 | 65 |
GO:0009986 | cell surface | 7.19e-02 | 1.00e+00 | 2.165 | 2 | 9 | 402 |
GO:0010468 | regulation of gene expression | 7.29e-02 | 1.00e+00 | 3.729 | 1 | 2 | 68 |
GO:0003697 | single-stranded DNA binding | 7.29e-02 | 1.00e+00 | 3.729 | 1 | 5 | 68 |
GO:0055086 | nucleobase-containing small molecule metabolic process | 7.49e-02 | 1.00e+00 | 3.687 | 1 | 1 | 70 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 7.49e-02 | 1.00e+00 | 3.687 | 1 | 2 | 70 |
GO:0042826 | histone deacetylase binding | 7.70e-02 | 1.00e+00 | 3.646 | 1 | 4 | 72 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 7.70e-02 | 1.00e+00 | 3.646 | 1 | 1 | 72 |
GO:0003729 | mRNA binding | 7.70e-02 | 1.00e+00 | 3.646 | 1 | 4 | 72 |
GO:0006366 | transcription from RNA polymerase II promoter | 7.73e-02 | 1.00e+00 | 2.105 | 2 | 30 | 419 |
GO:0000981 | sequence-specific DNA binding RNA polymerase II transcription factor activity | 7.90e-02 | 1.00e+00 | 3.607 | 1 | 4 | 74 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 7.90e-02 | 1.00e+00 | 3.607 | 1 | 2 | 74 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 8.01e-02 | 1.00e+00 | 3.587 | 1 | 1 | 75 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 8.01e-02 | 1.00e+00 | 3.587 | 1 | 1 | 75 |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 8.21e-02 | 1.00e+00 | 3.549 | 1 | 3 | 77 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 8.42e-02 | 1.00e+00 | 3.512 | 1 | 2 | 79 |
GO:0030968 | endoplasmic reticulum unfolded protein response | 8.42e-02 | 1.00e+00 | 3.512 | 1 | 2 | 79 |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | 8.52e-02 | 1.00e+00 | 3.494 | 1 | 5 | 80 |
GO:0051301 | cell division | 8.62e-02 | 1.00e+00 | 3.476 | 1 | 2 | 81 |
GO:0009653 | anatomical structure morphogenesis | 8.82e-02 | 1.00e+00 | 3.441 | 1 | 2 | 83 |
GO:0005681 | spliceosomal complex | 8.82e-02 | 1.00e+00 | 3.441 | 1 | 3 | 83 |
GO:0090090 | negative regulation of canonical Wnt signaling pathway | 9.13e-02 | 1.00e+00 | 3.390 | 1 | 8 | 86 |
GO:0050821 | protein stabilization | 9.33e-02 | 1.00e+00 | 3.357 | 1 | 3 | 88 |
GO:0005739 | mitochondrion | 9.42e-02 | 1.00e+00 | 1.438 | 3 | 23 | 998 |
GO:0007010 | cytoskeleton organization | 9.64e-02 | 1.00e+00 | 3.308 | 1 | 4 | 91 |
GO:0045893 | positive regulation of transcription, DNA-templated | 9.69e-02 | 1.00e+00 | 1.915 | 2 | 24 | 478 |
GO:0005737 | cytoplasm | 9.70e-02 | 1.00e+00 | 0.744 | 7 | 124 | 3767 |
GO:0051015 | actin filament binding | 9.74e-02 | 1.00e+00 | 3.293 | 1 | 3 | 92 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 9.74e-02 | 1.00e+00 | 3.293 | 1 | 1 | 92 |
GO:0005770 | late endosome | 9.84e-02 | 1.00e+00 | 3.277 | 1 | 2 | 93 |
GO:0051082 | unfolded protein binding | 9.84e-02 | 1.00e+00 | 3.277 | 1 | 7 | 93 |
GO:0008360 | regulation of cell shape | 1.08e-01 | 1.00e+00 | 3.130 | 1 | 4 | 103 |
GO:0003676 | nucleic acid binding | 1.12e-01 | 1.00e+00 | 3.075 | 1 | 2 | 107 |
GO:0070062 | extracellular vesicular exosome | 1.13e-01 | 1.00e+00 | 0.909 | 5 | 57 | 2400 |
GO:0030308 | negative regulation of cell growth | 1.15e-01 | 1.00e+00 | 3.035 | 1 | 6 | 110 |
GO:0030529 | ribonucleoprotein complex | 1.17e-01 | 1.00e+00 | 3.009 | 1 | 5 | 112 |
GO:0016032 | viral process | 1.17e-01 | 1.00e+00 | 1.755 | 2 | 26 | 534 |
GO:0000209 | protein polyubiquitination | 1.21e-01 | 1.00e+00 | 2.958 | 1 | 3 | 116 |
GO:0007050 | cell cycle arrest | 1.29e-01 | 1.00e+00 | 2.862 | 1 | 5 | 124 |
GO:0016477 | cell migration | 1.33e-01 | 1.00e+00 | 2.816 | 1 | 4 | 128 |
GO:0016055 | Wnt signaling pathway | 1.43e-01 | 1.00e+00 | 2.708 | 1 | 4 | 138 |
GO:0016887 | ATPase activity | 1.45e-01 | 1.00e+00 | 2.687 | 1 | 1 | 140 |
GO:0000082 | G1/S transition of mitotic cell cycle | 1.53e-01 | 1.00e+00 | 2.597 | 1 | 3 | 149 |
GO:0005769 | early endosome | 1.56e-01 | 1.00e+00 | 2.568 | 1 | 1 | 152 |
GO:0046777 | protein autophosphorylation | 1.62e-01 | 1.00e+00 | 2.512 | 1 | 4 | 158 |
GO:0000287 | magnesium ion binding | 1.67e-01 | 1.00e+00 | 2.459 | 1 | 4 | 164 |
GO:0005524 | ATP binding | 1.69e-01 | 1.00e+00 | 1.059 | 3 | 31 | 1298 |
GO:0034641 | cellular nitrogen compound metabolic process | 1.74e-01 | 1.00e+00 | 2.398 | 1 | 2 | 171 |
GO:0007049 | cell cycle | 1.77e-01 | 1.00e+00 | 2.373 | 1 | 6 | 174 |
GO:0005667 | transcription factor complex | 1.78e-01 | 1.00e+00 | 2.365 | 1 | 17 | 175 |
GO:0004672 | protein kinase activity | 1.79e-01 | 1.00e+00 | 2.348 | 1 | 3 | 177 |
GO:0031625 | ubiquitin protein ligase binding | 1.80e-01 | 1.00e+00 | 2.340 | 1 | 5 | 178 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 1.80e-01 | 1.00e+00 | 1.367 | 2 | 39 | 699 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 1.86e-01 | 1.00e+00 | 2.293 | 1 | 22 | 184 |
GO:0003924 | GTPase activity | 1.98e-01 | 1.00e+00 | 2.194 | 1 | 7 | 197 |
GO:0006184 | GTP catabolic process | 2.13e-01 | 1.00e+00 | 2.075 | 1 | 7 | 214 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 2.17e-01 | 1.00e+00 | 1.192 | 2 | 41 | 789 |
GO:0016071 | mRNA metabolic process | 2.21e-01 | 1.00e+00 | 2.015 | 1 | 8 | 223 |
GO:0003713 | transcription coactivator activity | 2.33e-01 | 1.00e+00 | 1.927 | 1 | 24 | 237 |
GO:0016070 | RNA metabolic process | 2.42e-01 | 1.00e+00 | 1.868 | 1 | 8 | 247 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 2.56e-01 | 1.00e+00 | 1.772 | 1 | 23 | 264 |
GO:0043065 | positive regulation of apoptotic process | 2.59e-01 | 1.00e+00 | 1.750 | 1 | 7 | 268 |
GO:0019899 | enzyme binding | 2.67e-01 | 1.00e+00 | 1.702 | 1 | 9 | 277 |
GO:0006200 | ATP catabolic process | 2.79e-01 | 1.00e+00 | 1.626 | 1 | 2 | 292 |
GO:0005525 | GTP binding | 2.94e-01 | 1.00e+00 | 1.540 | 1 | 12 | 310 |
GO:0008283 | cell proliferation | 3.08e-01 | 1.00e+00 | 1.459 | 1 | 14 | 328 |
GO:0008285 | negative regulation of cell proliferation | 3.27e-01 | 1.00e+00 | 1.353 | 1 | 10 | 353 |
GO:0005925 | focal adhesion | 3.37e-01 | 1.00e+00 | 1.300 | 1 | 9 | 366 |
GO:0046982 | protein heterodimerization activity | 3.48e-01 | 1.00e+00 | 1.246 | 1 | 8 | 380 |
GO:0000278 | mitotic cell cycle | 3.56e-01 | 1.00e+00 | 1.205 | 1 | 15 | 391 |
GO:0044281 | small molecule metabolic process | 3.94e-01 | 1.00e+00 | 0.574 | 2 | 20 | 1211 |
GO:0044267 | cellular protein metabolic process | 4.14e-01 | 1.00e+00 | 0.927 | 1 | 20 | 474 |
GO:0006915 | apoptotic process | 4.66e-01 | 1.00e+00 | 0.700 | 1 | 12 | 555 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 4.76e-01 | 1.00e+00 | 0.661 | 1 | 37 | 570 |
GO:0042803 | protein homodimerization activity | 4.91e-01 | 1.00e+00 | 0.599 | 1 | 19 | 595 |
GO:0005887 | integral component of plasma membrane | 6.38e-01 | 1.00e+00 | 0.022 | 1 | 10 | 888 |
GO:0007165 | signal transduction | 6.46e-01 | 1.00e+00 | -0.009 | 1 | 13 | 907 |
GO:0005615 | extracellular space | 6.67e-01 | 1.00e+00 | -0.086 | 1 | 20 | 957 |
GO:0008270 | zinc ion binding | 6.82e-01 | 1.00e+00 | -0.145 | 1 | 27 | 997 |
GO:0005886 | plasma membrane | 8.09e-01 | 1.00e+00 | -0.518 | 2 | 49 | 2582 |
GO:0006351 | transcription, DNA-templated | 8.16e-01 | 1.00e+00 | -0.682 | 1 | 57 | 1446 |