int-snw-122622

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.870 6.90e-16 3.15e-04 2.50e-03
chia-screen-data-Fav-int-snw-122622 subnetwork

Genes (16)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
MED19 219541 30-2.6573.449115Yes-
PSMD2 5708 47-4.1723.157386YesYes
PHB2 11331 5-2.2362.994140Yes-
LUC7L3 51747 33-3.5233.44918Yes-
PHB 5245 15-2.7433.004127YesYes
YAP1 10413 94-4.2563.53853Yes-
POU5F1 5460 133-5.1483.538179YesYes
HSPD1 3329 3-1.8522.870286--
HNRNPU 3192 76-2.8693.538139Yes-
HAGH 3029 1-1.5622.87032--
[ ADSSL1 ] 122622 1-1.2242.87036--
SON 6651 9-3.8443.1089YesYes
CDK12 51755 6-2.7142.94415Yes-
DDIT3 1649 60-2.8253.504343YesYes
SF3A1 10291 4-2.7873.12943YesYes
PRPF40A 55660 2-1.5113.108199--

Interactions (19)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
SF3A1 10291 PRPF40A 55660 pp -- int.I2D: BioGrid, Pawson1;
int.Mint: MI:0915(physical association)
PRPF40A 55660 ADSSL1 122622 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, IntAct_Yeast
HSPD1 3329 PHB2 11331 pp -- int.I2D: IntAct_Yeast
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
PSMD2 5708 ADSSL1 122622 pp -- int.I2D: BioGrid_Yeast
SON 6651 PRPF40A 55660 pp -- int.I2D: BIND, MINT, HPRD;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
HSPD1 3329 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
HAGH 3029 ADSSL1 122622 pp -- int.I2D: YeastLow
PHB 5245 PHB2 11331 pp -- int.I2D: BioGrid, BioGrid_Yeast, IntAct_Yeast
HSPD1 3329 ADSSL1 122622 pp -- int.I2D: IntAct_Yeast
HNRNPU 3192 PRPF40A 55660 pp -- int.I2D: BioGrid, Pawson1
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
PHB2 11331 ADSSL1 122622 pp -- int.I2D: YeastMedium
LUC7L3 51747 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
PHB 5245 ADSSL1 122622 pp -- int.I2D: YeastMedium
DDIT3 1649 HSPD1 3329 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
CDK12 51755 PRPF40A 55660 pp -- int.I2D: BioGrid, BIND, MINT, Pawson1, HPRD;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
PSMD2 5708 PHB2 11331 pp -- int.I2D: IntAct_Yeast

Related GO terms (232)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0008380RNA splicing1.03e-071.48e-034.568622228
GO:0006397mRNA processing2.39e-053.45e-014.494410160
GO:0044212transcription regulatory region DNA binding2.90e-054.18e-014.424417168
GO:0016607nuclear speck3.18e-054.58e-014.390412172
GO:0044822poly(A) RNA binding7.02e-051.00e+002.5797501056
GO:0005654nucleoplasm8.21e-051.00e+002.5447641082
GO:0042789mRNA transcription from RNA polymerase II promoter8.94e-051.00e+007.1162213
GO:0005634nucleus4.55e-041.00e+001.247121594559
GO:0042594response to starvation5.27e-041.00e+005.8622431
GO:0060795cell fate commitment involved in formation of primary germ layer1.11e-031.00e+009.816111
GO:0002842positive regulation of T cell mediated immune response to tumor cell1.11e-031.00e+009.816111
GO:2000016negative regulation of determination of dorsal identity1.11e-031.00e+009.816111
GO:0048291isotype switching to IgG isotypes1.11e-031.00e+009.816111
GO:0090308regulation of methylation-dependent chromatin silencing1.11e-031.00e+009.816111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway1.11e-031.00e+009.816111
GO:0060965negative regulation of gene silencing by miRNA1.11e-031.00e+009.816111
GO:0002368B cell cytokine production1.11e-031.00e+009.816111
GO:0006986response to unfolded protein1.37e-031.00e+005.1722450
GO:0005515protein binding1.51e-031.00e+000.960131986024
GO:0060242contact inhibition2.22e-031.00e+008.816112
GO:0005684U2-type spliceosomal complex2.22e-031.00e+008.816112
GO:0004019adenylosuccinate synthase activity2.22e-031.00e+008.816112
GO:0070816phosphorylation of RNA polymerase II C-terminal domain2.22e-031.00e+008.816112
GO:0009786regulation of asymmetric cell division2.22e-031.00e+008.816112
GO:0002944cyclin K-CDK12 complex2.22e-031.00e+008.816112
GO:0004416hydroxyacylglutathione hydrolase activity2.22e-031.00e+008.816112
GO:0044324regulation of transcription involved in anterior/posterior axis specification2.22e-031.00e+008.816112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress2.22e-031.00e+008.816112
GO:0005743mitochondrial inner membrane3.26e-031.00e+003.28736277
GO:0071013catalytic step 2 spliceosome3.30e-031.00e+004.5312778
GO:0006458'de novo' protein folding3.32e-031.00e+008.231113
GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex3.32e-031.00e+008.231113
GO:0046040IMP metabolic process3.32e-031.00e+008.231113
GO:0044208'de novo' AMP biosynthetic process3.32e-031.00e+008.231113
GO:0060913cardiac cell fate determination3.32e-031.00e+008.231113
GO:0003130BMP signaling pathway involved in heart induction3.32e-031.00e+008.231113
GO:0030135coated vesicle3.32e-031.00e+008.231113
GO:0006167AMP biosynthetic process4.43e-031.00e+007.816114
GO:0016363nuclear matrix4.46e-031.00e+004.3082691
GO:0001649osteoblast differentiation4.56e-031.00e+004.2932592
GO:0051726regulation of cell cycle5.05e-031.00e+004.2162597
GO:0010467gene expression5.34e-031.00e+002.430445669
GO:0001714endodermal cell fate specification5.54e-031.00e+007.494115
GO:0046696lipopolysaccharide receptor complex5.54e-031.00e+007.494115
GO:0043620regulation of DNA-templated transcription in response to stress5.54e-031.00e+007.494115
GO:0070934CRD-mediated mRNA stabilization5.54e-031.00e+007.494125
GO:0033600negative regulation of mammary gland epithelial cell proliferation5.54e-031.00e+007.494115
GO:0000389mRNA 3'-splice site recognition5.54e-031.00e+007.494125
GO:0043405regulation of MAP kinase activity5.54e-031.00e+007.494115
GO:0003723RNA binding5.88e-031.00e+002.983318342
GO:0050847progesterone receptor signaling pathway6.64e-031.00e+007.231126
GO:0003688DNA replication origin binding6.64e-031.00e+007.231116
GO:0006531aspartate metabolic process6.64e-031.00e+007.231116
GO:0060744mammary gland branching involved in thelarche6.64e-031.00e+007.231126
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex6.64e-031.00e+007.231116
GO:0050733RS domain binding6.64e-031.00e+007.231116
GO:2000323negative regulation of glucocorticoid receptor signaling pathway6.64e-031.00e+007.231116
GO:0070937CRD-mediated mRNA stability complex6.64e-031.00e+007.231136
GO:0060762regulation of branching involved in mammary gland duct morphogenesis6.64e-031.00e+007.231126
GO:0071354cellular response to interleukin-67.74e-031.00e+007.009127
GO:0003677DNA binding8.45e-031.00e+001.8885491218
GO:0014850response to muscle activity8.84e-031.00e+006.816118
GO:0001955blood vessel maturation8.84e-031.00e+006.816118
GO:0051604protein maturation8.84e-031.00e+006.816128
GO:0045892negative regulation of transcription, DNA-templated9.89e-031.00e+002.711324413
GO:0006983ER overload response9.94e-031.00e+006.646119
GO:0010944negative regulation of transcription by competitive promoter binding9.94e-031.00e+006.646119
GO:0043066negative regulation of apoptotic process1.06e-021.00e+002.673316424
GO:0035413positive regulation of catenin import into nucleus1.10e-021.00e+006.4941210
GO:0042301phosphate ion binding1.10e-021.00e+006.4941110
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway1.10e-021.00e+006.4941210
GO:0043032positive regulation of macrophage activation1.10e-021.00e+006.4941110
GO:0006750glutathione biosynthetic process1.10e-021.00e+006.4941110
GO:0042981regulation of apoptotic process1.17e-021.00e+003.58724150
GO:0006974cellular response to DNA damage stimulus1.19e-021.00e+003.57827151
GO:0032727positive regulation of interferon-alpha production1.21e-021.00e+006.3571111
GO:0071257cellular response to electrical stimulus1.21e-021.00e+006.3571211
GO:0045662negative regulation of myoblast differentiation1.21e-021.00e+006.3571311
GO:0060391positive regulation of SMAD protein import into nucleus1.21e-021.00e+006.3571411
GO:0009168purine ribonucleoside monophosphate biosynthetic process1.32e-021.00e+006.2311112
GO:0005838proteasome regulatory particle1.32e-021.00e+006.2311112
GO:0035198miRNA binding1.32e-021.00e+006.2311112
GO:0000398mRNA splicing, via spliceosome1.39e-021.00e+003.459215164
GO:0060766negative regulation of androgen receptor signaling pathway1.43e-021.00e+006.1161313
GO:0071480cellular response to gamma radiation1.43e-021.00e+006.1161113
GO:0030234enzyme regulator activity1.43e-021.00e+006.1161213
GO:0001530lipopolysaccharide binding1.43e-021.00e+006.1161113
GO:0051131chaperone-mediated protein complex assembly1.43e-021.00e+006.1161113
GO:0005685U1 snRNP1.54e-021.00e+006.0091114
GO:0032465regulation of cytokinesis1.54e-021.00e+006.0091114
GO:0003714transcription corepressor activity1.62e-021.00e+003.340211178
GO:0001824blastocyst development1.65e-021.00e+005.9091215
GO:0060749mammary gland alveolus development1.65e-021.00e+005.9091215
GO:0042026protein refolding1.65e-021.00e+005.9091115
GO:0006376mRNA splice site selection1.65e-021.00e+005.9091115
GO:0042176regulation of protein catabolic process1.76e-021.00e+005.8161216
GO:0008353RNA polymerase II carboxy-terminal domain kinase activity1.76e-021.00e+005.8161116
GO:0006541glutamine metabolic process1.87e-021.00e+005.7291217
GO:0050870positive regulation of T cell activation1.87e-021.00e+005.7291117
GO:0022624proteasome accessory complex1.87e-021.00e+005.7291117
GO:0030332cyclin binding1.98e-021.00e+005.6461118
GO:0070064proline-rich region binding1.98e-021.00e+005.6461118
GO:0032733positive regulation of interleukin-10 production2.09e-021.00e+005.5681219
GO:0006355regulation of transcription, DNA-templated2.11e-021.00e+001.855443997
GO:0032757positive regulation of interleukin-8 production2.20e-021.00e+005.4941120
GO:0042100B cell proliferation2.31e-021.00e+005.4241121
GO:0016575histone deacetylation2.31e-021.00e+005.4241321
GO:0043484regulation of RNA splicing2.41e-021.00e+005.3571122
GO:0036464cytoplasmic ribonucleoprotein granule2.41e-021.00e+005.3571222
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress2.52e-021.00e+005.2931123
GO:0005759mitochondrial matrix2.58e-021.00e+002.98324228
GO:0042113B cell activation2.74e-021.00e+005.1721225
GO:0032735positive regulation of interleukin-12 production2.74e-021.00e+005.1721225
GO:0005730nucleolus2.83e-021.00e+001.4585661641
GO:0035329hippo signaling2.85e-021.00e+005.1161526
GO:0051209release of sequestered calcium ion into cytosol2.85e-021.00e+005.1161126
GO:0008134transcription factor binding2.88e-021.00e+002.897218242
GO:0030331estrogen receptor binding2.96e-021.00e+005.0611227
GO:0071897DNA biosynthetic process3.06e-021.00e+005.0091128
GO:0016020membrane3.10e-021.00e+001.4235461681
GO:0006144purine nucleobase metabolic process3.28e-021.00e+004.9091130
GO:0004693cyclin-dependent protein serine/threonine kinase activity3.39e-021.00e+004.8621131
GO:0002376immune system process3.49e-021.00e+004.8161332
GO:1903507negative regulation of nucleic acid-templated transcription3.49e-021.00e+004.8161232
GO:0001104RNA polymerase II transcription cofactor activity3.60e-021.00e+004.7721833
GO:0016592mediator complex3.81e-021.00e+004.68711035
GO:0032755positive regulation of interleukin-6 production3.92e-021.00e+004.6461236
GO:0043234protein complex4.14e-021.00e+002.612211295
GO:0032729positive regulation of interferon-gamma production4.24e-021.00e+004.5311139
GO:0035019somatic stem cell maintenance4.35e-021.00e+004.4941640
GO:0005829cytosol4.44e-021.00e+001.1166862496
GO:0042110T cell activation4.56e-021.00e+004.4241142
GO:0043525positive regulation of neuron apoptotic process4.99e-021.00e+004.2931446
GO:0035690cellular response to drug5.30e-021.00e+004.2011349
GO:0006521regulation of cellular amino acid metabolic process5.41e-021.00e+004.1721150
GO:0005905coated pit5.41e-021.00e+004.1721650
GO:0034976response to endoplasmic reticulum stress5.51e-021.00e+004.1441251
GO:0045454cell redox homeostasis5.51e-021.00e+004.1441151
GO:0000910cytokinesis5.51e-021.00e+004.1441251
GO:0043565sequence-specific DNA binding5.52e-021.00e+002.381211346
GO:0003725double-stranded RNA binding5.62e-021.00e+004.1161152
GO:0000226microtubule cytoskeleton organization5.62e-021.00e+004.1161252
GO:0009611response to wounding5.62e-021.00e+004.1161552
GO:0002039p53 binding5.93e-021.00e+004.0351455
GO:0000502proteasome complex6.25e-021.00e+003.9581358
GO:0006396RNA processing6.35e-021.00e+003.9331559
GO:0051087chaperone binding6.35e-021.00e+003.9331359
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity6.35e-021.00e+003.9331659
GO:0006987activation of signaling protein activity involved in unfolded protein response6.56e-021.00e+003.8851261
GO:0030141secretory granule6.66e-021.00e+003.8621462
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest6.87e-021.00e+003.8161164
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.98e-021.00e+003.7941265
GO:0009986cell surface7.19e-021.00e+002.16529402
GO:0010468regulation of gene expression7.29e-021.00e+003.7291268
GO:0003697single-stranded DNA binding7.29e-021.00e+003.7291568
GO:0055086nucleobase-containing small molecule metabolic process7.49e-021.00e+003.6871170
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.49e-021.00e+003.6871270
GO:0042826histone deacetylase binding7.70e-021.00e+003.6461472
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent7.70e-021.00e+003.6461172
GO:0003729mRNA binding7.70e-021.00e+003.6461472
GO:0006366transcription from RNA polymerase II promoter7.73e-021.00e+002.105230419
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity7.90e-021.00e+003.6071474
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.90e-021.00e+003.6071274
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process8.01e-021.00e+003.5871175
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I8.01e-021.00e+003.5871175
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process8.21e-021.00e+003.5491377
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process8.42e-021.00e+003.5121279
GO:0030968endoplasmic reticulum unfolded protein response8.42e-021.00e+003.5121279
GO:0002755MyD88-dependent toll-like receptor signaling pathway8.52e-021.00e+003.4941580
GO:0051301cell division8.62e-021.00e+003.4761281
GO:0009653anatomical structure morphogenesis8.82e-021.00e+003.4411283
GO:0005681spliceosomal complex8.82e-021.00e+003.4411383
GO:0090090negative regulation of canonical Wnt signaling pathway9.13e-021.00e+003.3901886
GO:0050821protein stabilization9.33e-021.00e+003.3571388
GO:0005739mitochondrion9.42e-021.00e+001.438323998
GO:0007010cytoskeleton organization9.64e-021.00e+003.3081491
GO:0045893positive regulation of transcription, DNA-templated9.69e-021.00e+001.915224478
GO:0005737cytoplasm9.70e-021.00e+000.74471243767
GO:0051015actin filament binding9.74e-021.00e+003.2931392
GO:0002474antigen processing and presentation of peptide antigen via MHC class I9.74e-021.00e+003.2931192
GO:0005770late endosome9.84e-021.00e+003.2771293
GO:0051082unfolded protein binding9.84e-021.00e+003.2771793
GO:0008360regulation of cell shape1.08e-011.00e+003.13014103
GO:0003676nucleic acid binding1.12e-011.00e+003.07512107
GO:0070062extracellular vesicular exosome1.13e-011.00e+000.9095572400
GO:0030308negative regulation of cell growth1.15e-011.00e+003.03516110
GO:0030529ribonucleoprotein complex1.17e-011.00e+003.00915112
GO:0016032viral process1.17e-011.00e+001.755226534
GO:0000209protein polyubiquitination1.21e-011.00e+002.95813116
GO:0007050cell cycle arrest1.29e-011.00e+002.86215124
GO:0016477cell migration1.33e-011.00e+002.81614128
GO:0016055Wnt signaling pathway1.43e-011.00e+002.70814138
GO:0016887ATPase activity1.45e-011.00e+002.68711140
GO:0000082G1/S transition of mitotic cell cycle1.53e-011.00e+002.59713149
GO:0005769early endosome1.56e-011.00e+002.56811152
GO:0046777protein autophosphorylation1.62e-011.00e+002.51214158
GO:0000287magnesium ion binding1.67e-011.00e+002.45914164
GO:0005524ATP binding1.69e-011.00e+001.0593311298
GO:0034641cellular nitrogen compound metabolic process1.74e-011.00e+002.39812171
GO:0007049cell cycle1.77e-011.00e+002.37316174
GO:0005667transcription factor complex1.78e-011.00e+002.365117175
GO:0004672protein kinase activity1.79e-011.00e+002.34813177
GO:0031625ubiquitin protein ligase binding1.80e-011.00e+002.34015178
GO:0003700sequence-specific DNA binding transcription factor activity1.80e-011.00e+001.367239699
GO:0006367transcription initiation from RNA polymerase II promoter1.86e-011.00e+002.293122184
GO:0003924GTPase activity1.98e-011.00e+002.19417197
GO:0006184GTP catabolic process2.13e-011.00e+002.07517214
GO:0045944positive regulation of transcription from RNA polymerase II promoter2.17e-011.00e+001.192241789
GO:0016071mRNA metabolic process2.21e-011.00e+002.01518223
GO:0003713transcription coactivator activity2.33e-011.00e+001.927124237
GO:0016070RNA metabolic process2.42e-011.00e+001.86818247
GO:0006357regulation of transcription from RNA polymerase II promoter2.56e-011.00e+001.772123264
GO:0043065positive regulation of apoptotic process2.59e-011.00e+001.75017268
GO:0019899enzyme binding2.67e-011.00e+001.70219277
GO:0006200ATP catabolic process2.79e-011.00e+001.62612292
GO:0005525GTP binding2.94e-011.00e+001.540112310
GO:0008283cell proliferation3.08e-011.00e+001.459114328
GO:0008285negative regulation of cell proliferation3.27e-011.00e+001.353110353
GO:0005925focal adhesion3.37e-011.00e+001.30019366
GO:0046982protein heterodimerization activity3.48e-011.00e+001.24618380
GO:0000278mitotic cell cycle3.56e-011.00e+001.205115391
GO:0044281small molecule metabolic process3.94e-011.00e+000.5742201211
GO:0044267cellular protein metabolic process4.14e-011.00e+000.927120474
GO:0006915apoptotic process4.66e-011.00e+000.700112555
GO:0000122negative regulation of transcription from RNA polymerase II promoter4.76e-011.00e+000.661137570
GO:0042803protein homodimerization activity4.91e-011.00e+000.599119595
GO:0005887integral component of plasma membrane6.38e-011.00e+000.022110888
GO:0007165signal transduction6.46e-011.00e+00-0.009113907
GO:0005615extracellular space6.67e-011.00e+00-0.086120957
GO:0008270zinc ion binding6.82e-011.00e+00-0.145127997
GO:0005886plasma membrane8.09e-011.00e+00-0.5182492582
GO:0006351transcription, DNA-templated8.16e-011.00e+00-0.6821571446