int-snw-11171

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.838 1.56e-15 4.69e-04 3.32e-03
chia-screen-data-Fav-int-snw-11171 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
EP300 2033 22-2.2743.120415YesYes
ACTR6 64431 1-2.1612.83834Yes-
NCBP1 4686 6-2.5103.14940YesYes
YAP1 10413 94-4.2563.53853Yes-
NXF1 10482 10-2.4263.53865YesYes
HES6 55502 8-2.5573.12011YesYes
TCL1A 8115 8-2.4573.12011YesYes
SRSF3 6428 73-2.9923.53854Yes-
YY1 7528 24-2.5723.120114YesYes
HNRNPU 3192 76-2.8693.538139Yes-
POU5F1 5460 133-5.1483.538179YesYes
[ STRAP ] 11171 1-1.8402.83857--
DDIT3 1649 60-2.8253.504343YesYes

Interactions (16)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
SRSF3 6428 NXF1 10482 pp -- int.I2D: MINT, HPRD;
int.Mint: MI:0407(direct interaction), MI:0915(physical association)
EP300 2033 YY1 7528 pp -- int.I2D: BioGrid, BCI, HPRD;
int.Transfac: -;
int.Ravasi: -;
int.HPRD: in vivo;
int.DIP: MI:0218(physical interaction)
HNRNPU 3192 NXF1 10482 pp -- int.Intact: MI:0914(association)
EP300 2033 STRAP 11171 pp -- int.I2D: MINT;
int.Mint: MI:0915(physical association)
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
EP300 2033 HES6 55502 pp -- int.I2D: IntAct
DDIT3 1649 EP300 2033 pp -- int.Intact: MI:0915(physical association)
EP300 2033 TCL1A 8115 pp -- int.I2D: INNATEDB
EP300 2033 YAP1 10413 pp -- int.I2D: BioGrid
STRAP 11171 ACTR6 64431 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
NCBP1 4686 NXF1 10482 pp -- int.Mint: MI:0914(association)
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
EP300 2033 HNRNPU 3192 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vitro, in vivo
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
NXF1 10482 STRAP 11171 pp -- int.I2D: HPRD;
int.HPRD: yeast 2-hybrid

Related GO terms (248)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm8.95e-071.29e-023.0368641082
GO:0044212transcription regulatory region DNA binding1.17e-051.69e-014.723417168
GO:0005667transcription factor complex1.37e-051.98e-014.664417175
GO:0006406mRNA export from nucleus2.00e-052.88e-015.7703461
GO:0008134transcription factor binding4.91e-057.08e-014.197418242
GO:0042789mRNA transcription from RNA polymerase II promoter5.82e-058.39e-017.4152213
GO:0044822poly(A) RNA binding1.66e-041.00e+002.6566501056
GO:0003723RNA binding1.87e-041.00e+003.698418342
GO:0010467gene expression1.99e-041.00e+003.052545669
GO:0005515protein binding2.24e-041.00e+001.144121986024
GO:0003700sequence-specific DNA binding transcription factor activity2.45e-041.00e+002.988539699
GO:0000387spliceosomal snRNP assembly2.60e-041.00e+006.3612227
GO:0006974cellular response to DNA damage stimulus2.98e-041.00e+004.46237151
GO:0003677DNA binding3.66e-041.00e+002.4506491218
GO:0000398mRNA splicing, via spliceosome3.80e-041.00e+004.343315164
GO:0003714transcription corepressor activity4.83e-041.00e+004.225311178
GO:0031124mRNA 3'-end processing6.33e-041.00e+005.7232242
GO:0006369termination of RNA polymerase II transcription7.26e-041.00e+005.6242245
GO:0060795cell fate commitment involved in formation of primary germ layer9.01e-041.00e+0010.116111
GO:0060177regulation of angiotensin metabolic process9.01e-041.00e+0010.116111
GO:2000016negative regulation of determination of dorsal identity9.01e-041.00e+0010.116111
GO:1901985positive regulation of protein acetylation9.01e-041.00e+0010.116111
GO:0043969histone H2B acetylation9.01e-041.00e+0010.116111
GO:2000629negative regulation of miRNA metabolic process9.01e-041.00e+0010.116111
GO:0090308regulation of methylation-dependent chromatin silencing9.01e-041.00e+0010.116111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway9.01e-041.00e+0010.116111
GO:0060965negative regulation of gene silencing by miRNA9.01e-041.00e+0010.116111
GO:0008380RNA splicing9.92e-041.00e+003.868322228
GO:0005634nucleus1.03e-031.00e+001.283101594559
GO:0003713transcription coactivator activity1.11e-031.00e+003.812324237
GO:0006355regulation of transcription, DNA-templated1.26e-031.00e+002.476543997
GO:0034696response to prostaglandin F1.80e-031.00e+009.116112
GO:0060242contact inhibition1.80e-031.00e+009.116112
GO:0014737positive regulation of muscle atrophy1.80e-031.00e+009.116112
GO:0006403RNA localization1.80e-031.00e+009.116112
GO:0005846nuclear cap binding complex1.80e-031.00e+009.116112
GO:0009786regulation of asymmetric cell division1.80e-031.00e+009.116112
GO:0090043regulation of tubulin deacetylation1.80e-031.00e+009.116122
GO:0035984cellular response to trichostatin A1.80e-031.00e+009.116112
GO:0071389cellular response to mineralocorticoid stimulus1.80e-031.00e+009.116112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.80e-031.00e+009.116112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.80e-031.00e+009.116112
GO:0018076N-terminal peptidyl-lysine acetylation2.70e-031.00e+008.531113
GO:0060913cardiac cell fate determination2.70e-031.00e+008.531113
GO:0003130BMP signaling pathway involved in heart induction2.70e-031.00e+008.531113
GO:0010560positive regulation of glycoprotein biosynthetic process2.70e-031.00e+008.531113
GO:0097157pre-mRNA intronic binding3.60e-031.00e+008.116114
GO:0018393internal peptidyl-lysine acetylation3.60e-031.00e+008.116114
GO:0030529ribonucleoprotein complex4.41e-031.00e+004.30825112
GO:0001714endodermal cell fate specification4.50e-031.00e+007.794115
GO:0065004protein-DNA complex assembly4.50e-031.00e+007.794115
GO:0045292mRNA cis splicing, via spliceosome4.50e-031.00e+007.794115
GO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor4.50e-031.00e+007.794115
GO:0043620regulation of DNA-templated transcription in response to stress4.50e-031.00e+007.794115
GO:0070934CRD-mediated mRNA stabilization4.50e-031.00e+007.794125
GO:0031442positive regulation of mRNA 3'-end processing4.50e-031.00e+007.794115
GO:0060298positive regulation of sarcomere organization4.50e-031.00e+007.794115
GO:0032025response to cobalt ion4.50e-031.00e+007.794115
GO:0070937CRD-mediated mRNA stability complex5.40e-031.00e+007.531136
GO:0006366transcription from RNA polymerase II promoter5.60e-031.00e+002.990330419
GO:0006475internal protein amino acid acetylation6.29e-031.00e+007.308117
GO:0016973poly(A)+ mRNA export from nucleus7.19e-031.00e+007.116118
GO:0001955blood vessel maturation7.19e-031.00e+007.116118
GO:0000339RNA cap binding7.19e-031.00e+007.116118
GO:0042405nuclear inclusion body8.09e-031.00e+006.946129
GO:0060765regulation of androgen receptor signaling pathway8.09e-031.00e+006.946119
GO:0010225response to UV-C8.09e-031.00e+006.946129
GO:0006379mRNA cleavage8.09e-031.00e+006.946119
GO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation8.09e-031.00e+006.946119
GO:0006983ER overload response8.09e-031.00e+006.946119
GO:0035259glucocorticoid receptor binding8.09e-031.00e+006.946119
GO:0045793positive regulation of cell size8.09e-031.00e+006.946129
GO:0000400four-way junction DNA binding8.09e-031.00e+006.946119
GO:0035413positive regulation of catenin import into nucleus8.98e-031.00e+006.7941210
GO:0016407acetyltransferase activity8.98e-031.00e+006.7941210
GO:0043923positive regulation by host of viral transcription9.87e-031.00e+006.6561111
GO:0005845mRNA cap binding complex9.87e-031.00e+006.6561111
GO:0032797SMN complex9.87e-031.00e+006.6561111
GO:0033160positive regulation of protein import into nucleus, translocation9.87e-031.00e+006.6561311
GO:0030277maintenance of gastrointestinal epithelium9.87e-031.00e+006.6561211
GO:0045662negative regulation of myoblast differentiation9.87e-031.00e+006.6561311
GO:0042975peroxisome proliferator activated receptor binding9.87e-031.00e+006.6561111
GO:0045120pronucleus9.87e-031.00e+006.6561211
GO:0060391positive regulation of SMAD protein import into nucleus9.87e-031.00e+006.6561411
GO:0016607nuclear speck1.01e-021.00e+003.689212172
GO:0010633negative regulation of epithelial cell migration1.08e-021.00e+006.5311112
GO:0008334histone mRNA metabolic process1.08e-021.00e+006.5311112
GO:0035198miRNA binding1.08e-021.00e+006.5311112
GO:0016032viral process1.09e-021.00e+002.640326534
GO:0071480cellular response to gamma radiation1.17e-021.00e+006.4151113
GO:0051019mitogen-activated protein kinase binding1.17e-021.00e+006.4151213
GO:0016746transferase activity, transferring acyl groups1.17e-021.00e+006.4151113
GO:0000346transcription export complex1.17e-021.00e+006.4151113
GO:0070542response to fatty acid1.26e-021.00e+006.3081114
GO:0031011Ino80 complex1.26e-021.00e+006.3081614
GO:0032993protein-DNA complex1.26e-021.00e+006.3081214
GO:0005487nucleocytoplasmic transporter activity1.26e-021.00e+006.3081314
GO:0000122negative regulation of transcription from RNA polymerase II promoter1.31e-021.00e+002.546337570
GO:0001824blastocyst development1.34e-021.00e+006.2091215
GO:1990090cellular response to nerve growth factor stimulus1.34e-021.00e+006.2091115
GO:0043274phospholipase binding1.43e-021.00e+006.1161116
GO:0051276chromosome organization1.43e-021.00e+006.1161216
GO:0034719SMN-Sm protein complex1.43e-021.00e+006.1161116
GO:0048593camera-type eye morphogenesis1.43e-021.00e+006.1161116
GO:0005829cytosol1.51e-021.00e+001.4156862496
GO:0045773positive regulation of axon extension1.61e-021.00e+005.9461118
GO:0033613activating transcription factor binding1.61e-021.00e+005.9461318
GO:0010719negative regulation of epithelial to mesenchymal transition1.70e-021.00e+005.8681119
GO:0035257nuclear hormone receptor binding1.70e-021.00e+005.8681119
GO:0007399nervous system development1.77e-021.00e+003.26426231
GO:0071549cellular response to dexamethasone stimulus1.79e-021.00e+005.7941320
GO:0010942positive regulation of cell death1.79e-021.00e+005.7941120
GO:0032757positive regulation of interleukin-8 production1.79e-021.00e+005.7941120
GO:0000123histone acetyltransferase complex1.88e-021.00e+005.7231621
GO:0032967positive regulation of collagen biosynthetic process1.88e-021.00e+005.7231321
GO:0045862positive regulation of proteolysis1.88e-021.00e+005.7231221
GO:0003823antigen binding1.97e-021.00e+005.6561222
GO:0036464cytoplasmic ribonucleoprotein granule1.97e-021.00e+005.6561222
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress2.05e-021.00e+005.5921123
GO:0034660ncRNA metabolic process2.05e-021.00e+005.5921123
GO:0043388positive regulation of DNA binding2.14e-021.00e+005.5311224
GO:0043425bHLH transcription factor binding2.14e-021.00e+005.5311124
GO:0000166nucleotide binding2.20e-021.00e+003.099213259
GO:0031047gene silencing by RNA2.23e-021.00e+005.4721225
GO:0051059NF-kappaB binding2.23e-021.00e+005.4721325
GO:0031519PcG protein complex2.23e-021.00e+005.4721125
GO:0006357regulation of transcription from RNA polymerase II promoter2.28e-021.00e+003.071223264
GO:0035329hippo signaling2.32e-021.00e+005.4151526
GO:0051209release of sequestered calcium ion into cytosol2.32e-021.00e+005.4151126
GO:0048565digestive tract development2.32e-021.00e+005.4151226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.32e-021.00e+005.4151126
GO:0034612response to tumor necrosis factor2.41e-021.00e+005.3611227
GO:0043967histone H4 acetylation2.41e-021.00e+005.3611127
GO:0050714positive regulation of protein secretion2.50e-021.00e+005.3081328
GO:0034644cellular response to UV2.67e-021.00e+005.2091130
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator2.67e-021.00e+005.2091130
GO:00063707-methylguanosine mRNA capping2.67e-021.00e+005.2091530
GO:0042594response to starvation2.76e-021.00e+005.1611431
GO:0043491protein kinase B signaling2.85e-021.00e+005.1161232
GO:1903507negative regulation of nucleic acid-templated transcription2.85e-021.00e+005.1161232
GO:0030154cell differentiation2.91e-021.00e+002.88225301
GO:0071333cellular response to glucose stimulus2.94e-021.00e+005.0711133
GO:0001756somitogenesis2.94e-021.00e+005.0711133
GO:0005737cytoplasm3.06e-021.00e+001.04471243767
GO:0045944positive regulation of transcription from RNA polymerase II promoter3.09e-021.00e+002.077341789
GO:0001102RNA polymerase II activating transcription factor binding3.20e-021.00e+004.9461136
GO:0006446regulation of translational initiation3.20e-021.00e+004.9461436
GO:0032092positive regulation of protein binding3.37e-021.00e+004.8681238
GO:0031490chromatin DNA binding3.37e-021.00e+004.8681238
GO:0050681androgen receptor binding3.37e-021.00e+004.8681138
GO:0035019somatic stem cell maintenance3.55e-021.00e+004.7941640
GO:0007519skeletal muscle tissue development3.55e-021.00e+004.7941240
GO:0046332SMAD binding3.55e-021.00e+004.7941240
GO:0071320cellular response to cAMP3.55e-021.00e+004.7941140
GO:0070301cellular response to hydrogen peroxide3.63e-021.00e+004.7581241
GO:0043565sequence-specific DNA binding3.76e-021.00e+002.681211346
GO:0004402histone acetyltransferase activity3.81e-021.00e+004.6891643
GO:0050434positive regulation of viral transcription3.90e-021.00e+004.6561544
GO:0045727positive regulation of translation3.90e-021.00e+004.6561244
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding3.90e-021.00e+004.6561444
GO:0003712transcription cofactor activity3.90e-021.00e+004.6561844
GO:0043966histone H3 acetylation3.98e-021.00e+004.6241545
GO:0001047core promoter binding3.98e-021.00e+004.6241545
GO:0043525positive regulation of neuron apoptotic process4.07e-021.00e+004.5921446
GO:0019827stem cell maintenance4.16e-021.00e+004.5611747
GO:0035690cellular response to drug4.33e-021.00e+004.5011349
GO:0006986response to unfolded protein4.42e-021.00e+004.4721450
GO:0034976response to endoplasmic reticulum stress4.50e-021.00e+004.4431251
GO:0045454cell redox homeostasis4.50e-021.00e+004.4431151
GO:0050680negative regulation of epithelial cell proliferation4.50e-021.00e+004.4431251
GO:0009611response to wounding4.59e-021.00e+004.4151552
GO:0007623circadian rhythm4.68e-021.00e+004.3881153
GO:0071300cellular response to retinoic acid4.85e-021.00e+004.3341155
GO:0051592response to calcium ion4.85e-021.00e+004.3341155
GO:0000724double-strand break repair via homologous recombination4.85e-021.00e+004.3341255
GO:0002039p53 binding4.85e-021.00e+004.3341455
GO:0043627response to estrogen4.93e-021.00e+004.3081556
GO:0005643nuclear pore5.02e-021.00e+004.28311157
GO:0006396RNA processing5.19e-021.00e+004.2331559
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription5.19e-021.00e+004.2331559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity5.19e-021.00e+004.2331659
GO:0008013beta-catenin binding5.28e-021.00e+004.2091960
GO:0032481positive regulation of type I interferon production5.36e-021.00e+004.1851661
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway5.36e-021.00e+004.1851261
GO:0006987activation of signaling protein activity involved in unfolded protein response5.36e-021.00e+004.1851261
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process5.53e-021.00e+004.1381463
GO:0006368transcription elongation from RNA polymerase II promoter5.88e-021.00e+004.0501667
GO:0010468regulation of gene expression5.96e-021.00e+004.0281268
GO:0003729mRNA binding6.30e-021.00e+003.9461472
GO:0030324lung development6.30e-021.00e+003.9461172
GO:0000785chromatin6.39e-021.00e+003.9261673
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity6.47e-021.00e+003.9061474
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.56e-021.00e+003.8871175
GO:0001889liver development6.72e-021.00e+003.8491377
GO:0071013catalytic step 2 spliceosome6.81e-021.00e+003.8301778
GO:0030968endoplasmic reticulum unfolded protein response6.89e-021.00e+003.8121279
GO:0009653anatomical structure morphogenesis7.23e-021.00e+003.7411283
GO:0009952anterior/posterior pattern specification7.23e-021.00e+003.7411483
GO:0009887organ morphogenesis7.48e-021.00e+003.6891586
GO:0090090negative regulation of canonical Wnt signaling pathway7.48e-021.00e+003.6891886
GO:0045471response to ethanol7.48e-021.00e+003.6891386
GO:0016363nuclear matrix7.90e-021.00e+003.6081691
GO:0001649osteoblast differentiation7.99e-021.00e+003.5921592
GO:0071456cellular response to hypoxia7.99e-021.00e+003.5921392
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity7.99e-021.00e+003.5921792
GO:0005770late endosome8.07e-021.00e+003.5761293
GO:0051726regulation of cell cycle8.40e-021.00e+003.5161597
GO:0005938cell cortex8.98e-021.00e+003.41515104
GO:0001934positive regulation of protein phosphorylation8.98e-021.00e+003.41515104
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay9.81e-021.00e+003.28314114
GO:0046983protein dimerization activity1.01e-011.00e+003.23315118
GO:0006325chromatin organization1.01e-011.00e+003.233112118
GO:0007219Notch signaling pathway1.03e-011.00e+003.20915120
GO:0007050cell cycle arrest1.06e-011.00e+003.16115124
GO:0007179transforming growth factor beta receptor signaling pathway1.09e-011.00e+003.116111128
GO:0000086G2/M transition of mitotic cell cycle1.16e-011.00e+003.02814136
GO:0007507heart development1.18e-011.00e+002.99717139
GO:0016055Wnt signaling pathway1.18e-011.00e+003.00714138
GO:0001666response to hypoxia1.26e-011.00e+002.89617149
GO:0006351transcription, DNA-templated1.35e-011.00e+001.2033571446
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.39e-011.00e+002.749112165
GO:0031625ubiquitin protein ligase binding1.49e-011.00e+002.64015178
GO:0032403protein complex binding1.53e-011.00e+002.60016183
GO:0006367transcription initiation from RNA polymerase II promoter1.54e-011.00e+002.592122184
GO:0016071mRNA metabolic process1.83e-011.00e+002.31518223
GO:0016070RNA metabolic process2.01e-011.00e+002.16718247
GO:0005102receptor binding2.11e-011.00e+002.09312260
GO:0007283spermatogenesis2.12e-011.00e+002.08213262
GO:0008270zinc ion binding2.25e-011.00e+001.154227997
GO:0005856cytoskeleton2.33e-011.00e+001.93119291
GO:0007275multicellular organismal development2.50e-011.00e+001.81217316
GO:0003682chromatin binding2.58e-011.00e+001.762119327
GO:0008283cell proliferation2.59e-011.00e+001.758114328
GO:0030054cell junction2.64e-011.00e+001.72315336
GO:0046982protein heterodimerization activity2.93e-011.00e+001.54618380
GO:0000278mitotic cell cycle3.01e-011.00e+001.505115391
GO:0009986cell surface3.08e-011.00e+001.46519402
GO:0045892negative regulation of transcription, DNA-templated3.15e-011.00e+001.426124413
GO:0044267cellular protein metabolic process3.52e-011.00e+001.227120474
GO:0045893positive regulation of transcription, DNA-templated3.55e-011.00e+001.215124478
GO:0006915apoptotic process4.00e-011.00e+000.999112555
GO:0005783endoplasmic reticulum4.00e-011.00e+000.997113556
GO:0045087innate immune response4.22e-011.00e+000.896115596
GO:0005730nucleolus4.45e-011.00e+000.4352661641
GO:0005739mitochondrion6.06e-011.00e+000.153123998
GO:0005886plasma membrane7.05e-011.00e+00-0.2192492582
GO:0005524ATP binding7.07e-011.00e+00-0.2261311298
GO:0016020membrane8.00e-011.00e+00-0.5991461681