reg-snw-83998

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.204 2.76e-07 4.58e-02 3.48e-02
chia-screen-data-Fav-reg-snw-83998 subnetwork

Genes (14)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Transcription factor Chia-Hits Primary Chia-Hits Secondary
JUP 3728 1-1.3702.2043TF--
IGFBP6 3489 1-2.6252.2042-YesYes
WWTR1 25937 1-1.8862.20443TF--
PHB 5245 82-2.7432.68936-YesYes
TCF3 6929 1-1.2272.20498TF--
POLR2E 5434 30-2.0372.644201TFYes-
FTSJ1 24140 43-2.4632.68935-YesYes
VARS 7407 60-2.3662.689124TFYes-
HNRNPU 3192 39-2.8692.64433-Yes-
TPM1 7168 1-2.6862.2045-YesYes
GPS1 2873 86-3.6212.68936TFYesYes
[ REG4 ] 83998 1-0.6262.2041---
GLI1 2735 1-1.3442.20416TF--
NPEPL1 79716 1-2.9862.2041TFYesYes

Interactions (17)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
GLI1 2735 TCF3 6929 pd < reg.TRANSFAC.txt: no annot
VARS 7407 FTSJ1 24140 pd > reg.ITFP.txt: no annot
PHB 5245 VARS 7407 pd < reg.ITFP.txt: no annot
TCF3 6929 NPEPL1 79716 pd <> reg.ITFP.txt: no annot
TPM1 7168 WWTR1 25937 pd < reg.ITFP.txt: no annot
POLR2E 5434 FTSJ1 24140 pd > reg.ITFP.txt: no annot
TCF3 6929 VARS 7407 pd <> reg.ITFP.txt: no annot
POLR2E 5434 VARS 7407 pd <> reg.ITFP.txt: no annot
POLR2E 5434 TCF3 6929 pd <> reg.ITFP.txt: no annot
GLI1 2735 IGFBP6 3489 pd > reg.TRANSFAC.txt: no annot
HNRNPU 3192 POLR2E 5434 pd < reg.ITFP.txt: no annot
TCF3 6929 WWTR1 25937 pd <> reg.ITFP.txt: no annot
TCF3 6929 FTSJ1 24140 pd > reg.ITFP.txt: no annot
GLI1 2735 REG4 83998 pd > reg.TRANSFAC.txt: no annot
HNRNPU 3192 TCF3 6929 pd < reg.ITFP.txt: no annot
GPS1 2873 PHB 5245 pd > reg.ITFP.txt: no annot
GLI1 2735 JUP 3728 pd > reg.TRANSFAC.txt: no annot

Related GO terms (250)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0001649osteoblast differentiation2.87e-062.80e-025.2374574
GO:0044212transcription regulatory region DNA binding9.94e-041.00e+003.871313143
GO:0005667transcription factor complex1.08e-031.00e+003.83138147
GO:0003065positive regulation of heart rate by epinephrine1.43e-031.00e+009.446111
GO:0004832valine-tRNA ligase activity1.43e-031.00e+009.446111
GO:0005199structural constituent of cell wall1.43e-031.00e+009.446111
GO:0002128tRNA nucleoside ribose methylation1.43e-031.00e+009.446111
GO:0060390regulation of SMAD protein import into nucleus1.43e-031.00e+009.446111
GO:2001065mannan binding1.43e-031.00e+009.446111
GO:0008175tRNA methyltransferase activity1.43e-031.00e+009.446111
GO:0006438valyl-tRNA aminoacylation1.43e-031.00e+009.446111
GO:0071665gamma-catenin-TCF7L2 complex1.43e-031.00e+009.446111
GO:0003713transcription coactivator activity2.06e-031.00e+003.507321184
GO:0071603endothelial cell-cell adhesion2.87e-031.00e+008.446112
GO:0060032notochord regression2.87e-031.00e+008.446112
GO:0090090negative regulation of canonical Wnt signaling pathway3.12e-031.00e+004.5632559
GO:0000122negative regulation of transcription from RNA polymerase II promoter3.23e-031.00e+002.613429456
GO:0005737cytoplasm3.77e-031.00e+001.25391272633
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity4.00e-031.00e+004.3802567
GO:0070644vitamin D response element binding4.30e-031.00e+007.861113
GO:0003308negative regulation of Wnt signaling pathway involved in heart development4.30e-031.00e+007.861113
GO:0033152immunoglobulin V(D)J recombination4.30e-031.00e+007.861113
GO:0003136negative regulation of heart induction by canonical Wnt signaling pathway4.30e-031.00e+007.861113
GO:0005862muscle thin filament tropomyosin4.30e-031.00e+007.861113
GO:0007418ventral midline development4.30e-031.00e+007.861113
GO:0002326B cell lineage commitment5.72e-031.00e+007.446114
GO:0021938smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation5.72e-031.00e+007.446114
GO:0002159desmosome assembly5.72e-031.00e+007.446114
GO:0010467gene expression5.74e-031.00e+002.383449535
GO:0005654nucleoplasm5.78e-031.00e+001.993568876
GO:0009913epidermal cell differentiation7.15e-031.00e+007.124125
GO:0071681cellular response to indole-3-methanol7.15e-031.00e+007.124115
GO:0008235metalloexopeptidase activity7.15e-031.00e+007.124125
GO:0021696cerebellar cortex morphogenesis7.15e-031.00e+007.124115
GO:0070934CRD-mediated mRNA stabilization7.15e-031.00e+007.124125
GO:0035414negative regulation of catenin import into nucleus7.15e-031.00e+007.124115
GO:0000788nuclear nucleosome7.15e-031.00e+007.124115
GO:0086069bundle of His cell to Purkinje myocyte communication7.15e-031.00e+007.124115
GO:0032059bleb7.15e-031.00e+007.124115
GO:2000323negative regulation of glucocorticoid receptor signaling pathway7.15e-031.00e+007.124115
GO:0002161aminoacyl-tRNA editing activity7.15e-031.00e+007.124115
GO:0072307regulation of metanephric nephron tubule epithelial cell differentiation7.15e-031.00e+007.124115
GO:0050847progesterone receptor signaling pathway8.57e-031.00e+006.861126
GO:0002181cytoplasmic translation8.57e-031.00e+006.861116
GO:0001055RNA polymerase II activity8.57e-031.00e+006.861136
GO:0005915zonula adherens8.57e-031.00e+006.861116
GO:0048599oocyte development8.57e-031.00e+006.861116
GO:0017145stem cell division8.57e-031.00e+006.861116
GO:0070937CRD-mediated mRNA stability complex8.57e-031.00e+006.861126
GO:0045294alpha-catenin binding8.57e-031.00e+006.861116
GO:0050982detection of mechanical stimulus1.00e-021.00e+006.639117
GO:0030056hemidesmosome1.00e-021.00e+006.639117
GO:0048541Peyer's patch development1.00e-021.00e+006.639127
GO:0016342catenin complex1.00e-021.00e+006.639117
GO:0031994insulin-like growth factor I binding1.00e-021.00e+006.639117
GO:0032835glomerulus development1.00e-021.00e+006.639117
GO:0016327apicolateral plasma membrane1.00e-021.00e+006.639117
GO:0006450regulation of translational fidelity1.14e-021.00e+006.446118
GO:0010944negative regulation of transcription by competitive promoter binding1.14e-021.00e+006.446118
GO:0003181atrioventricular valve morphogenesis1.14e-021.00e+006.446118
GO:0010388cullin deneddylation1.14e-021.00e+006.446148
GO:0071354cellular response to interleukin-61.28e-021.00e+006.276119
GO:0005916fascia adherens1.28e-021.00e+006.276119
GO:0016331morphogenesis of embryonic epithelium1.28e-021.00e+006.276119
GO:0034614cellular response to reactive oxygen species1.28e-021.00e+006.276129
GO:0006937regulation of muscle contraction1.28e-021.00e+006.276119
GO:0000398mRNA splicing, via spliceosome1.40e-021.00e+003.446215128
GO:0005736DNA-directed RNA polymerase I complex1.43e-021.00e+006.1241410
GO:0005095GTPase inhibitor activity1.43e-021.00e+006.1241110
GO:0031529ruffle organization1.43e-021.00e+006.1241210
GO:0086005ventricular cardiac muscle cell action potential1.43e-021.00e+006.1241110
GO:0001779natural killer cell differentiation1.43e-021.00e+006.1241110
GO:0001054RNA polymerase I activity1.43e-021.00e+006.1241410
GO:0048468cell development1.43e-021.00e+006.1241110
GO:0045893positive regulation of transcription, DNA-templated1.51e-021.00e+002.473321377
GO:0060766negative regulation of androgen receptor signaling pathway1.57e-021.00e+005.9871411
GO:0035326enhancer binding1.57e-021.00e+005.9871111
GO:0007016cytoskeletal anchoring at plasma membrane1.57e-021.00e+005.9871111
GO:0048546digestive tract morphogenesis1.57e-021.00e+005.9871111
GO:2000045regulation of G1/S transition of mitotic cell cycle1.57e-021.00e+005.9871111
GO:0086091regulation of heart rate by cardiac conduction1.57e-021.00e+005.9871111
GO:0007398ectoderm development1.57e-021.00e+005.9871111
GO:0005634nucleus1.70e-021.00e+000.95291583246
GO:0042307positive regulation of protein import into nucleus1.71e-021.00e+005.8611312
GO:0090002establishment of protein localization to plasma membrane1.85e-021.00e+005.7461113
GO:0008589regulation of smoothened signaling pathway1.85e-021.00e+005.7461113
GO:0005666DNA-directed RNA polymerase III complex1.85e-021.00e+005.7461313
GO:0005665DNA-directed RNA polymerase II, core complex1.85e-021.00e+005.7461313
GO:0001056RNA polymerase III activity1.85e-021.00e+005.7461313
GO:0045214sarcomere organization1.85e-021.00e+005.7461113
GO:0032993protein-DNA complex1.85e-021.00e+005.7461113
GO:0006386termination of RNA polymerase III transcription1.99e-021.00e+005.6391314
GO:0031941filamentous actin1.99e-021.00e+005.6391114
GO:0006385transcription elongation from RNA polymerase III promoter1.99e-021.00e+005.6391314
GO:0016575histone deacetylation1.99e-021.00e+005.6391214
GO:0004177aminopeptidase activity1.99e-021.00e+005.6391314
GO:0072372primary cilium1.99e-021.00e+005.6391114
GO:0042803protein homodimerization activity2.12e-021.00e+002.290313428
GO:0030057desmosome2.13e-021.00e+005.5391215
GO:0032781positive regulation of ATPase activity2.13e-021.00e+005.5391215
GO:0000188inactivation of MAPK activity2.13e-021.00e+005.5391115
GO:0045880positive regulation of smoothened signaling pathway2.13e-021.00e+005.5391115
GO:0006367transcription initiation from RNA polymerase II promoter2.16e-021.00e+003.115218161
GO:0008380RNA splicing2.26e-021.00e+003.080221165
GO:0009954proximal/distal pattern formation2.41e-021.00e+005.3591217
GO:0007369gastrulation2.41e-021.00e+005.3591217
GO:0009953dorsal/ventral pattern formation2.55e-021.00e+005.2761218
GO:0003899DNA-directed RNA polymerase activity2.55e-021.00e+005.2761318
GO:0030017sarcomere2.55e-021.00e+005.2761218
GO:0031435mitogen-activated protein kinase kinase kinase binding2.55e-021.00e+005.2761118
GO:0043588skin development2.69e-021.00e+005.1981119
GO:0035329hippo signaling2.69e-021.00e+005.1981119
GO:0030049muscle filament sliding2.69e-021.00e+005.1981219
GO:0045787positive regulation of cell cycle2.69e-021.00e+005.1981119
GO:0036464cytoplasmic ribonucleoprotein granule2.69e-021.00e+005.1981119
GO:0055010ventricular cardiac muscle tissue morphogenesis2.83e-021.00e+005.1241120
GO:0045296cadherin binding2.83e-021.00e+005.1241220
GO:0010718positive regulation of epithelial to mesenchymal transition2.83e-021.00e+005.1241220
GO:0071897DNA biosynthetic process2.83e-021.00e+005.1241220
GO:0043425bHLH transcription factor binding2.83e-021.00e+005.1241120
GO:0005829cytosol2.93e-021.00e+001.2286881787
GO:0005856cytoskeleton2.94e-021.00e+002.87628190
GO:0008307structural constituent of muscle3.11e-021.00e+004.9871222
GO:0051149positive regulation of muscle cell differentiation3.11e-021.00e+004.9871222
GO:0021983pituitary gland development3.11e-021.00e+004.9871222
GO:0043967histone H4 acetylation3.11e-021.00e+004.9871122
GO:0014704intercalated disc3.25e-021.00e+004.9221223
GO:0070491repressing transcription factor binding3.25e-021.00e+004.9221223
GO:00063707-methylguanosine mRNA capping3.39e-021.00e+004.8611524
GO:0008180COP9 signalosome3.39e-021.00e+004.8611624
GO:0008016regulation of heart contraction3.39e-021.00e+004.8611124
GO:0070888E-box binding3.53e-021.00e+004.8021125
GO:0005913cell-cell adherens junction3.53e-021.00e+004.8021325
GO:0060271cilium morphogenesis3.67e-021.00e+004.7461126
GO:0030145manganese ion binding3.67e-021.00e+004.7461326
GO:0051496positive regulation of stress fiber assembly3.67e-021.00e+004.7461226
GO:0033077T cell differentiation in thymus3.67e-021.00e+004.7461226
GO:0060048cardiac muscle contraction3.67e-021.00e+004.7461126
GO:0006360transcription from RNA polymerase I promoter3.80e-021.00e+004.6911427
GO:0034332adherens junction organization3.94e-021.00e+004.6391128
GO:0009898cytoplasmic side of plasma membrane3.94e-021.00e+004.6391328
GO:0043966histone H3 acetylation3.94e-021.00e+004.6391428
GO:0042692muscle cell differentiation3.94e-021.00e+004.6391228
GO:0003677DNA binding3.99e-021.00e+001.559452947
GO:0045599negative regulation of fat cell differentiation4.08e-021.00e+004.5881229
GO:0006418tRNA aminoacylation for protein translation4.08e-021.00e+004.5881429
GO:0045785positive regulation of cell adhesion4.08e-021.00e+004.5881329
GO:0006383transcription from RNA polymerase III promoter4.08e-021.00e+004.5881629
GO:0001933negative regulation of protein phosphorylation4.22e-021.00e+004.5391330
GO:0016328lateral plasma membrane4.36e-021.00e+004.4921231
GO:0045740positive regulation of DNA replication4.49e-021.00e+004.4461132
GO:0030890positive regulation of B cell proliferation4.63e-021.00e+004.4021233
GO:0007254JNK cascade4.77e-021.00e+004.3591134
GO:0000902cell morphogenesis4.91e-021.00e+004.3171535
GO:0050434positive regulation of viral transcription4.91e-021.00e+004.3171535
GO:0003682chromatin binding4.92e-021.00e+002.469215252
GO:0008092cytoskeletal protein binding5.04e-021.00e+004.2761136
GO:0090263positive regulation of canonical Wnt signaling pathway5.04e-021.00e+004.2761236
GO:0007224smoothened signaling pathway5.45e-021.00e+004.1611139
GO:0006396RNA processing5.59e-021.00e+004.1241440
GO:0006283transcription-coupled nucleotide-excision repair5.59e-021.00e+004.1241640
GO:0005882intermediate filament5.59e-021.00e+004.1241140
GO:0008285negative regulation of cell proliferation5.83e-021.00e+002.332211277
GO:0008284positive regulation of cell proliferation5.90e-021.00e+002.32228279
GO:0030183B cell differentiation6.00e-021.00e+004.0201143
GO:0051291protein heterooligomerization6.00e-021.00e+004.0201143
GO:0045944positive regulation of transcription from RNA polymerase II promoter6.02e-021.00e+001.700329644
GO:0045216cell-cell junction organization6.13e-021.00e+003.9871144
GO:0001725stress fiber6.40e-021.00e+003.9221646
GO:0019903protein phosphatase binding6.54e-021.00e+003.8911247
GO:0032481positive regulation of type I interferon production6.67e-021.00e+003.8611348
GO:0001558regulation of cell growth6.80e-021.00e+003.8311249
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription6.94e-021.00e+003.8021250
GO:0032587ruffle membrane6.94e-021.00e+003.8021350
GO:0006469negative regulation of protein kinase activity6.94e-021.00e+003.8021250
GO:0006368transcription elongation from RNA polymerase II promoter7.21e-021.00e+003.7461852
GO:0006289nucleotide-excision repair7.34e-021.00e+003.7181653
GO:0045666positive regulation of neuron differentiation7.34e-021.00e+003.7181353
GO:0034329cell junction assembly7.34e-021.00e+003.7181253
GO:0006936muscle contraction7.47e-021.00e+003.6911554
GO:0042060wound healing7.61e-021.00e+003.6651155
GO:0006355regulation of transcription, DNA-templated7.76e-021.00e+001.549331715
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity8.01e-021.00e+003.5881358
GO:0042826histone deacetylase binding8.01e-021.00e+003.5881558
GO:0030336negative regulation of cell migration8.27e-021.00e+003.5391360
GO:0006366transcription from RNA polymerase II promoter8.39e-021.00e+002.032223341
GO:0071013catalytic step 2 spliceosome8.40e-021.00e+003.5151561
GO:0007010cytoskeleton organization8.40e-021.00e+003.5151461
GO:0016337single organismal cell-cell adhesion8.54e-021.00e+003.4921362
GO:0030324lung development8.54e-021.00e+003.4921162
GO:0050821protein stabilization8.80e-021.00e+003.4461364
GO:0030018Z disc8.80e-021.00e+003.4461364
GO:0005200structural constituent of cytoskeleton9.33e-021.00e+003.3591268
GO:0006928cellular component movement9.59e-021.00e+003.3171670
GO:0030308negative regulation of cell growth9.59e-021.00e+003.3171370
GO:0042127regulation of cell proliferation1.09e-011.00e+003.1241480
GO:0030529ribonucleoprotein complex1.11e-011.00e+003.0881582
GO:0008201heparin binding1.23e-011.00e+002.9381491
GO:0032496response to lipopolysaccharide1.25e-011.00e+002.9071193
GO:0016477cell migration1.29e-011.00e+002.8611396
GO:0008017microtubule binding1.31e-011.00e+002.8461997
GO:0005198structural molecule activity1.36e-011.00e+002.78814101
GO:0005911cell-cell junction1.39e-011.00e+002.74613104
GO:0016323basolateral plasma membrane1.42e-011.00e+002.71813106
GO:0007179transforming growth factor beta receptor signaling pathway1.43e-011.00e+002.70515107
GO:0000790nuclear chromatin1.46e-011.00e+002.67819109
GO:0042981regulation of apoptotic process1.49e-011.00e+002.63914112
GO:0007049cell cycle1.53e-011.00e+002.60118115
GO:0015629actin cytoskeleton1.78e-011.00e+002.35915136
GO:0003714transcription corepressor activity1.80e-011.00e+002.34815137
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.86e-011.00e+002.29617142
GO:0005515protein binding1.94e-011.00e+000.43681984124
GO:0007399nervous system development1.97e-011.00e+002.19814152
GO:0001701in utero embryonic development2.00e-011.00e+002.17917154
GO:0007283spermatogenesis2.16e-011.00e+002.05414168
GO:0007165signal transduction2.21e-011.00e+001.175224618
GO:0003779actin binding2.28e-011.00e+001.96213179
GO:0005739mitochondrion2.43e-011.00e+001.082232659
GO:0005576extracellular region2.45e-011.00e+001.073215663
GO:0005743mitochondrial inner membrane2.48e-011.00e+001.82419197
GO:0006281DNA repair2.55e-011.00e+001.781124203
GO:0008134transcription factor binding2.61e-011.00e+001.739110209
GO:0043234protein complex2.63e-011.00e+001.732113210
GO:0019899enzyme binding2.63e-011.00e+001.73217210
GO:0043231intracellular membrane-bounded organelle2.71e-011.00e+001.67818218
GO:0042493response to drug2.75e-011.00e+001.65214222
GO:0019901protein kinase binding2.86e-011.00e+001.58818232
GO:0003723RNA binding3.02e-011.00e+001.498122247
GO:0006508proteolysis3.19e-011.00e+001.402111264
GO:0046982protein heterodimerization activity3.20e-011.00e+001.396111265
GO:0043565sequence-specific DNA binding3.30e-011.00e+001.34318275
GO:0005925focal adhesion3.37e-011.00e+001.306114282
GO:0009986cell surface3.45e-011.00e+001.26115291
GO:0005524ATP binding3.70e-011.00e+000.645237892
GO:0045892negative regulation of transcription, DNA-templated3.70e-011.00e+001.138117317
GO:0005509calcium ion binding4.01e-011.00e+000.99119351
GO:0044267cellular protein metabolic process4.02e-011.00e+000.987114352
GO:0070062extracellular vesicular exosome4.26e-011.00e+000.3513511641
GO:0005794Golgi apparatus4.56e-011.00e+000.74916415
GO:0016032viral process4.66e-011.00e+000.705130428
GO:0006351transcription, DNA-templated4.67e-011.00e+000.3752471076
GO:0045087innate immune response4.85e-011.00e+000.626112452
GO:0016020membrane5.31e-011.00e+000.2092561207
GO:0005730nucleolus5.36e-011.00e+000.1972741217
GO:0005887integral component of plasma membrane5.73e-011.00e+000.27918575
GO:0003700sequence-specific DNA binding transcription factor activity5.77e-011.00e+000.261122582
GO:0005615extracellular space6.20e-011.00e+000.100115651
GO:0044822poly(A) RNA binding6.98e-011.00e+00-0.196145799
GO:0046872metal ion binding7.55e-011.00e+00-0.421124934
GO:0005886plasma membrane9.41e-011.00e+00-1.3551461784