reg-snw-5682

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.230	2.01e-07	3.88e-02	2.97e-02

chia-screen-data-Fav-reg-snw-5682 subnetwork

Genes (13)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Transcription factor	Chia-Hits Primary	Chia-Hits Secondary
KARS	3735	12	-1.759	2.428	123	TF	-	-
CENPA	1058	27	-2.185	2.393	205	TF	Yes	-
PHB2	11331	17	-2.236	2.449	11	-	Yes	-
COPS3	8533	8	-1.873	2.435	79	TF	-	-
PHB	5245	82	-2.743	2.689	36	-	Yes	Yes
POLR2E	5434	30	-2.037	2.644	201	TF	Yes	-
[ PSMA1 ]	5682	1	-1.363	2.230	29	-	-	-
GSPT1	2935	32	-2.313	2.503	17	-	Yes	Yes
EIF2B3	8891	8	-2.546	2.435	4	-	Yes	Yes
HNRNPU	3192	39	-2.869	2.644	33	-	Yes	-
GTF2A2	2958	9	-1.938	2.377	41	TF	-	-
GPS1	2873	86	-3.621	2.689	36	TF	Yes	Yes
PRPF40A	55660	3	-1.511	2.307	106	TF	-	-

Interactions (15)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMA1	5682	PRPF40A	55660	pd	<	reg.ITFP.txt: no annot
HNRNPU	3192	PRPF40A	55660	pd	<	reg.ITFP.txt: no annot
GTF2A2	2958	PSMA1	5682	pd	>	reg.ITFP.txt: no annot
GTF2A2	2958	PRPF40A	55660	pd	<>	reg.ITFP.txt: no annot
CENPA	1058	KARS	3735	pd	<>	reg.ITFP.txt: no annot
KARS	3735	PHB2	11331	pd	>	reg.ITFP.txt: no annot
HNRNPU	3192	POLR2E	5434	pd	<	reg.ITFP.txt: no annot
KARS	3735	PSMA1	5682	pd	>	reg.ITFP.txt: no annot
KARS	3735	PHB	5245	pd	>	reg.ITFP.txt: no annot
GSPT1	2935	KARS	3735	pd	<	reg.ITFP.txt: no annot
GPS1	2873	PHB	5245	pd	>	reg.ITFP.txt: no annot
COPS3	8533	EIF2B3	8891	pd	>	reg.ITFP.txt: no annot
POLR2E	5434	PRPF40A	55660	pd	<>	reg.ITFP.txt: no annot
GPS1	2873	PHB2	11331	pd	>	reg.ITFP.txt: no annot
PSMA1	5682	COPS3	8533	pd	<	reg.ITFP.txt: no annot

Related GO terms (173)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005515	protein binding	1.34e-05	1.31e-01	1.244	13	198	4124
GO:0010467	gene expression	3.24e-05	3.17e-01	3.075	6	49	535
GO:0010388	cullin deneddylation	4.56e-05	4.45e-01	7.553	2	4	8
GO:0016032	viral process	1.52e-04	1.00e+00	3.133	5	30	428
GO:0008180	COP9 signalosome	4.44e-04	1.00e+00	5.968	2	6	24
GO:0005654	nucleoplasm	5.06e-04	1.00e+00	2.363	6	68	876
GO:0008380	RNA splicing	1.20e-03	1.00e+00	3.772	3	21	165
GO:0006430	lysyl-tRNA aminoacylation	1.33e-03	1.00e+00	9.553	1	1	1
GO:0004824	lysine-tRNA ligase activity	1.33e-03	1.00e+00	9.553	1	1	1
GO:0000939	condensed chromosome inner kinetochore	1.33e-03	1.00e+00	9.553	1	1	1
GO:0005634	nucleus	1.60e-03	1.00e+00	1.210	10	158	3246
GO:0006368	transcription elongation from RNA polymerase II promoter	2.09e-03	1.00e+00	4.853	2	8	52
GO:0051716	cellular response to stimulus	2.66e-03	1.00e+00	8.553	1	1	2
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	2.66e-03	1.00e+00	8.553	1	1	2
GO:0003747	translation release factor activity	2.66e-03	1.00e+00	8.553	1	2	2
GO:0015966	diadenosine tetraphosphate biosynthetic process	2.66e-03	1.00e+00	8.553	1	1	2
GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly	2.66e-03	1.00e+00	8.553	1	1	2
GO:0000778	condensed nuclear chromosome kinetochore	3.99e-03	1.00e+00	7.968	1	2	3
GO:0071459	protein localization to chromosome, centromeric region	3.99e-03	1.00e+00	7.968	1	1	3
GO:0016363	nuclear matrix	4.08e-03	1.00e+00	4.363	2	10	73
GO:0001649	osteoblast differentiation	4.19e-03	1.00e+00	4.344	2	5	74
GO:0032057	negative regulation of translational initiation in response to stress	5.32e-03	1.00e+00	7.553	1	1	4
GO:0005851	eukaryotic translation initiation factor 2B complex	5.32e-03	1.00e+00	7.553	1	2	4
GO:0016779	nucleotidyltransferase activity	5.32e-03	1.00e+00	7.553	1	1	4
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	5.32e-03	1.00e+00	7.553	1	1	4
GO:0070934	CRD-mediated mRNA stabilization	6.64e-03	1.00e+00	7.231	1	2	5
GO:0005672	transcription factor TFIIA complex	6.64e-03	1.00e+00	7.231	1	1	5
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	6.64e-03	1.00e+00	7.231	1	1	5
GO:0060744	mammary gland branching involved in thelarche	6.64e-03	1.00e+00	7.231	1	1	5
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	6.64e-03	1.00e+00	7.231	1	1	5
GO:0050847	progesterone receptor signaling pathway	7.96e-03	1.00e+00	6.968	1	2	6
GO:0019773	proteasome core complex, alpha-subunit complex	7.96e-03	1.00e+00	6.968	1	1	6
GO:0001055	RNA polymerase II activity	7.96e-03	1.00e+00	6.968	1	3	6
GO:0070937	CRD-mediated mRNA stability complex	7.96e-03	1.00e+00	6.968	1	2	6
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	9.28e-03	1.00e+00	6.746	1	2	7
GO:0000780	condensed nuclear chromosome, centromeric region	9.28e-03	1.00e+00	6.746	1	1	7
GO:0051382	kinetochore assembly	9.28e-03	1.00e+00	6.746	1	2	7
GO:0042981	regulation of apoptotic process	9.36e-03	1.00e+00	3.746	2	4	112
GO:0007049	cell cycle	9.85e-03	1.00e+00	3.707	2	8	115
GO:0010944	negative regulation of transcription by competitive promoter binding	1.06e-02	1.00e+00	6.553	1	1	8
GO:0000082	G1/S transition of mitotic cell cycle	1.16e-02	1.00e+00	3.587	2	4	125
GO:0071354	cellular response to interleukin-6	1.19e-02	1.00e+00	6.383	1	1	9
GO:0000398	mRNA splicing, via spliceosome	1.21e-02	1.00e+00	3.553	2	15	128
GO:0005736	DNA-directed RNA polymerase I complex	1.32e-02	1.00e+00	6.231	1	4	10
GO:0005095	GTPase inhibitor activity	1.32e-02	1.00e+00	6.231	1	1	10
GO:0009416	response to light stimulus	1.32e-02	1.00e+00	6.231	1	1	10
GO:0001054	RNA polymerase I activity	1.32e-02	1.00e+00	6.231	1	4	10
GO:0032465	regulation of cytokinesis	1.32e-02	1.00e+00	6.231	1	1	10
GO:0060766	negative regulation of androgen receptor signaling pathway	1.46e-02	1.00e+00	6.094	1	4	11
GO:0006479	protein methylation	1.46e-02	1.00e+00	6.094	1	2	11
GO:0017025	TBP-class protein binding	1.59e-02	1.00e+00	5.968	1	1	12
GO:0000132	establishment of mitotic spindle orientation	1.59e-02	1.00e+00	5.968	1	2	12
GO:0005666	DNA-directed RNA polymerase III complex	1.72e-02	1.00e+00	5.853	1	3	13
GO:0005665	DNA-directed RNA polymerase II, core complex	1.72e-02	1.00e+00	5.853	1	3	13
GO:0001056	RNA polymerase III activity	1.72e-02	1.00e+00	5.853	1	3	13
GO:0060749	mammary gland alveolus development	1.72e-02	1.00e+00	5.853	1	1	13
GO:0006386	termination of RNA polymerase III transcription	1.85e-02	1.00e+00	5.746	1	3	14
GO:0070064	proline-rich region binding	1.85e-02	1.00e+00	5.746	1	1	14
GO:0006385	transcription elongation from RNA polymerase III promoter	1.85e-02	1.00e+00	5.746	1	3	14
GO:0016597	amino acid binding	1.85e-02	1.00e+00	5.746	1	1	14
GO:0016575	histone deacetylation	1.85e-02	1.00e+00	5.746	1	2	14
GO:0006367	transcription initiation from RNA polymerase II promoter	1.87e-02	1.00e+00	3.222	2	18	161
GO:0008135	translation factor activity, nucleic acid binding	1.98e-02	1.00e+00	5.646	1	4	15
GO:0000188	inactivation of MAPK activity	1.98e-02	1.00e+00	5.646	1	1	15
GO:0014003	oligodendrocyte development	1.98e-02	1.00e+00	5.646	1	1	15
GO:0005839	proteasome core complex	2.11e-02	1.00e+00	5.553	1	1	16
GO:0004298	threonine-type endopeptidase activity	2.24e-02	1.00e+00	5.466	1	1	17
GO:0003899	DNA-directed RNA polymerase activity	2.37e-02	1.00e+00	5.383	1	3	18
GO:0005844	polysome	2.50e-02	1.00e+00	5.305	1	2	19
GO:0036464	cytoplasmic ribonucleoprotein granule	2.50e-02	1.00e+00	5.305	1	1	19
GO:0034080	CENP-A containing nucleosome assembly	2.63e-02	1.00e+00	5.231	1	2	20
GO:0071897	DNA biosynthetic process	2.63e-02	1.00e+00	5.231	1	2	20
GO:0005743	mitochondrial inner membrane	2.73e-02	1.00e+00	2.931	2	9	197
GO:0030331	estrogen receptor binding	2.89e-02	1.00e+00	5.094	1	2	22
GO:0001103	RNA polymerase II repressing transcription factor binding	3.02e-02	1.00e+00	5.029	1	2	23
GO:0000049	tRNA binding	3.02e-02	1.00e+00	5.029	1	2	23
GO:0006370	7-methylguanosine mRNA capping	3.15e-02	1.00e+00	4.968	1	5	24
GO:0008033	tRNA processing	3.28e-02	1.00e+00	4.909	1	2	25
GO:0006360	transcription from RNA polymerase I promoter	3.54e-02	1.00e+00	4.798	1	4	27
GO:0006418	tRNA aminoacylation for protein translation	3.79e-02	1.00e+00	4.695	1	4	29
GO:0006383	transcription from RNA polymerase III promoter	3.79e-02	1.00e+00	4.695	1	6	29
GO:0009408	response to heat	4.05e-02	1.00e+00	4.599	1	1	31
GO:0003723	RNA binding	4.14e-02	1.00e+00	2.605	2	22	247
GO:0000786	nucleosome	4.44e-02	1.00e+00	4.466	1	2	34
GO:0007254	JNK cascade	4.44e-02	1.00e+00	4.466	1	1	34
GO:0050434	positive regulation of viral transcription	4.56e-02	1.00e+00	4.424	1	5	35
GO:0043434	response to peptide hormone	4.69e-02	1.00e+00	4.383	1	1	36
GO:0046982	protein heterodimerization activity	4.70e-02	1.00e+00	2.503	2	11	265
GO:0003743	translation initiation factor activity	4.82e-02	1.00e+00	4.344	1	8	37
GO:0006396	RNA processing	5.20e-02	1.00e+00	4.231	1	4	40
GO:0006283	transcription-coupled nucleotide-excision repair	5.20e-02	1.00e+00	4.231	1	6	40
GO:0005739	mitochondrion	5.26e-02	1.00e+00	1.774	3	32	659
GO:0006521	regulation of cellular amino acid metabolic process	5.33e-02	1.00e+00	4.195	1	2	41
GO:0000775	chromosome, centromeric region	5.33e-02	1.00e+00	4.195	1	6	41
GO:0005085	guanyl-nucleotide exchange factor activity	5.58e-02	1.00e+00	4.127	1	2	43
GO:0009749	response to glucose	5.83e-02	1.00e+00	4.061	1	1	45
GO:0000502	proteasome complex	6.08e-02	1.00e+00	3.998	1	3	47
GO:0032481	positive regulation of type I interferon production	6.21e-02	1.00e+00	3.968	1	3	48
GO:0051301	cell division	6.33e-02	1.00e+00	3.938	1	2	49
GO:0000278	mitotic cell cycle	6.36e-02	1.00e+00	2.258	2	28	314
GO:0045892	negative regulation of transcription, DNA-templated	6.47e-02	1.00e+00	2.245	2	17	317
GO:0006334	nucleosome assembly	6.58e-02	1.00e+00	3.881	1	4	51
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.71e-02	1.00e+00	3.853	1	3	52
GO:0006289	nucleotide-excision repair	6.83e-02	1.00e+00	3.825	1	6	53
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	6.83e-02	1.00e+00	3.825	1	3	53
GO:0005829	cytosol	7.21e-02	1.00e+00	1.072	5	88	1787
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.21e-02	1.00e+00	3.746	1	5	56
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	7.33e-02	1.00e+00	3.720	1	2	57
GO:0006366	transcription from RNA polymerase II promoter	7.36e-02	1.00e+00	2.139	2	23	341
GO:0042826	histone deacetylase binding	7.46e-02	1.00e+00	3.695	1	5	58
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.70e-02	1.00e+00	3.646	1	5	60
GO:0071013	catalytic step 2 spliceosome	7.83e-02	1.00e+00	3.622	1	5	61
GO:0007010	cytoskeleton organization	7.83e-02	1.00e+00	3.622	1	4	61
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	7.83e-02	1.00e+00	3.622	1	2	61
GO:0006415	translational termination	8.07e-02	1.00e+00	3.576	1	2	63
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	8.32e-02	1.00e+00	3.531	1	7	65
GO:0044822	poly(A) RNA binding	8.42e-02	1.00e+00	1.496	3	45	799
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	8.57e-02	1.00e+00	3.487	1	5	67
GO:0008360	regulation of cell shape	8.93e-02	1.00e+00	3.424	1	3	70
GO:0030308	negative regulation of cell growth	8.93e-02	1.00e+00	3.424	1	3	70
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	8.93e-02	1.00e+00	3.424	1	2	70
GO:0015630	microtubule cytoskeleton	9.54e-02	1.00e+00	3.324	1	5	75
GO:0030529	ribonucleoprotein complex	1.04e-01	1.00e+00	3.195	1	5	82
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1.06e-01	1.00e+00	3.161	1	5	84
GO:0005737	cytoplasm	1.09e-01	1.00e+00	0.775	6	127	2633
GO:0000209	protein polyubiquitination	1.16e-01	1.00e+00	3.029	1	6	92
GO:0016477	cell migration	1.21e-01	1.00e+00	2.968	1	3	96
GO:0006413	translational initiation	1.24e-01	1.00e+00	2.924	1	6	99
GO:0003677	DNA binding	1.25e-01	1.00e+00	1.251	3	52	947
GO:0034641	cellular nitrogen compound metabolic process	1.31e-01	1.00e+00	2.839	1	5	105
GO:0006397	mRNA processing	1.37e-01	1.00e+00	2.772	1	12	110
GO:0043547	positive regulation of GTPase activity	1.39e-01	1.00e+00	2.746	1	2	112
GO:0003924	GTPase activity	1.47e-01	1.00e+00	2.658	1	7	119
GO:0016607	nuclear speck	1.51e-01	1.00e+00	2.622	1	8	122
GO:0006184	GTP catabolic process	1.60e-01	1.00e+00	2.531	1	7	130
GO:0005759	mitochondrial matrix	1.70e-01	1.00e+00	2.434	1	7	139
GO:0044212	transcription regulatory region DNA binding	1.75e-01	1.00e+00	2.393	1	13	143
GO:0005622	intracellular	1.77e-01	1.00e+00	2.373	1	2	145
GO:0001701	in utero embryonic development	1.87e-01	1.00e+00	2.286	1	7	154
GO:0007165	signal transduction	1.97e-01	1.00e+00	1.282	2	24	618
GO:0016071	mRNA metabolic process	2.04e-01	1.00e+00	2.144	1	10	170
GO:0016020	membrane	2.11e-01	1.00e+00	0.901	3	56	1207
GO:0006412	translation	2.13e-01	1.00e+00	2.077	1	12	178
GO:0005730	nucleolus	2.15e-01	1.00e+00	0.889	3	74	1217
GO:0003713	transcription coactivator activity	2.19e-01	1.00e+00	2.029	1	21	184
GO:0016070	RNA metabolic process	2.23e-01	1.00e+00	1.998	1	10	188
GO:0005525	GTP binding	2.33e-01	1.00e+00	1.931	1	12	197
GO:0006281	DNA repair	2.39e-01	1.00e+00	1.888	1	24	203
GO:0008134	transcription factor binding	2.45e-01	1.00e+00	1.846	1	10	209
GO:0043234	protein complex	2.46e-01	1.00e+00	1.839	1	13	210
GO:0019899	enzyme binding	2.46e-01	1.00e+00	1.839	1	7	210
GO:0005813	centrosome	2.53e-01	1.00e+00	1.791	1	10	217
GO:0030054	cell junction	2.54e-01	1.00e+00	1.785	1	5	218
GO:0003682	chromatin binding	2.88e-01	1.00e+00	1.576	1	15	252
GO:0008285	negative regulation of cell proliferation	3.12e-01	1.00e+00	1.439	1	11	277
GO:0009986	cell surface	3.25e-01	1.00e+00	1.368	1	5	291
GO:0005524	ATP binding	3.36e-01	1.00e+00	0.752	2	37	892
GO:0043066	negative regulation of apoptotic process	3.53e-01	1.00e+00	1.222	1	8	322
GO:0070062	extracellular vesicular exosome	3.77e-01	1.00e+00	0.458	3	51	1641
GO:0044267	cellular protein metabolic process	3.80e-01	1.00e+00	1.094	1	14	352
GO:0045893	positive regulation of transcription, DNA-templated	4.01e-01	1.00e+00	0.995	1	21	377
GO:0006915	apoptotic process	4.28e-01	1.00e+00	0.870	1	15	411
GO:0042803	protein homodimerization activity	4.42e-01	1.00e+00	0.811	1	13	428
GO:0045087	innate immune response	4.60e-01	1.00e+00	0.733	1	12	452
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	4.63e-01	1.00e+00	0.720	1	29	456
GO:0005887	integral component of plasma membrane	5.46e-01	1.00e+00	0.386	1	8	575
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	5.88e-01	1.00e+00	0.222	1	29	644
GO:0005576	extracellular region	5.99e-01	1.00e+00	0.180	1	15	663
GO:0006355	regulation of transcription, DNA-templated	6.28e-01	1.00e+00	0.071	1	31	715
GO:0044281	small molecule metabolic process	6.91e-01	1.00e+00	-0.168	1	35	844
GO:0046872	metal ion binding	7.30e-01	1.00e+00	-0.314	1	24	934
GO:0006351	transcription, DNA-templated	7.81e-01	1.00e+00	-0.518	1	47	1076
GO:0005886	plasma membrane	9.28e-01	1.00e+00	-1.248	1	46	1784

chia-Fav

reg-snw-5682

Statistics

Genes (13)

Interactions (15)

Related GO terms (173)