reg-snw-5034

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.298 8.88e-08 2.50e-02 1.97e-02
chia-screen-data-Fav-reg-snw-5034 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Transcription factor Chia-Hits Primary Chia-Hits Secondary
RHOA 387 17-2.4082.64410-YesYes
EIF2S3 1968 3-1.9402.34513---
[ P4HB ] 5034 1-1.4502.29812---
SNAP23 8773 4-2.0732.43015-Yes-
PHB 5245 82-2.7432.68936-YesYes
FTSJ1 24140 43-2.4632.68935-YesYes
POLR2E 5434 30-2.0372.644201TFYes-
VARS 7407 60-2.3662.689124TFYes-
ARID4B 51742 3-2.0222.4309TFYes-
FUS 2521 11-1.9802.41453TF--
HNRNPU 3192 39-2.8692.64433-Yes-
GPS1 2873 86-3.6212.68936TFYesYes
MAPK14 1432 2-1.9022.38632---

Interactions (14)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
POLR2E 5434 SNAP23 8773 pd > reg.ITFP.txt: no annot
FUS 2521 POLR2E 5434 pd <> reg.ITFP.txt: no annot
VARS 7407 FTSJ1 24140 pd > reg.ITFP.txt: no annot
PHB 5245 VARS 7407 pd < reg.ITFP.txt: no annot
POLR2E 5434 FTSJ1 24140 pd > reg.ITFP.txt: no annot
POLR2E 5434 VARS 7407 pd <> reg.ITFP.txt: no annot
POLR2E 5434 ARID4B 51742 pd <> reg.ITFP.txt: no annot
P4HB 5034 POLR2E 5434 pd < reg.ITFP.txt: no annot
FUS 2521 HNRNPU 3192 pd > reg.ITFP.txt: no annot
HNRNPU 3192 POLR2E 5434 pd < reg.ITFP.txt: no annot
RHOA 387 POLR2E 5434 pd < reg.ITFP.txt: no annot
EIF2S3 1968 POLR2E 5434 pd < reg.ITFP.txt: no annot
MAPK14 1432 POLR2E 5434 pd < reg.ITFP.txt: no annot
GPS1 2873 PHB 5245 pd > reg.ITFP.txt: no annot

Related GO terms (227)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0010467gene expression3.24e-053.17e-013.075649535
GO:0000398mRNA splicing, via spliceosome5.72e-041.00e+004.138315128
GO:0008380RNA splicing1.20e-031.00e+003.772321165
GO:0004832valine-tRNA ligase activity1.33e-031.00e+009.553111
GO:0061383trabecula morphogenesis1.33e-031.00e+009.553111
GO:0002128tRNA nucleoside ribose methylation1.33e-031.00e+009.553111
GO:0038066p38MAPK cascade1.33e-031.00e+009.553111
GO:0008175tRNA methyltransferase activity1.33e-031.00e+009.553111
GO:0014835myoblast differentiation involved in skeletal muscle regeneration1.33e-031.00e+009.553111
GO:0006438valyl-tRNA aminoacylation1.33e-031.00e+009.553111
GO:0005515protein binding2.23e-031.00e+001.003111984124
GO:0004656procollagen-proline 4-dioxygenase activity2.66e-031.00e+008.553112
GO:0016222procollagen-proline 4-dioxygenase complex2.66e-031.00e+008.553112
GO:0033688regulation of osteoblast proliferation2.66e-031.00e+008.553112
GO:0090400stress-induced premature senescence3.99e-031.00e+007.968113
GO:1902175regulation of oxidative stress-induced intrinsic apoptotic signaling pathway3.99e-031.00e+007.968113
GO:0005654nucleoplasm4.01e-031.00e+002.100568876
GO:0001649osteoblast differentiation4.19e-031.00e+004.3442574
GO:0042582azurophil granule5.32e-031.00e+007.553114
GO:0034773histone H4-K20 trimethylation5.32e-031.00e+007.553114
GO:0036089cleavage furrow formation5.32e-031.00e+007.553114
GO:0036124histone H3-K9 trimethylation5.32e-031.00e+007.553124
GO:0005925focal adhesion5.50e-031.00e+002.998314282
GO:0038027apolipoprotein A-I-mediated signaling pathway6.64e-031.00e+007.231115
GO:0070934CRD-mediated mRNA stabilization6.64e-031.00e+007.231125
GO:0051525NFAT protein binding6.64e-031.00e+007.231115
GO:0043931ossification involved in bone maturation6.64e-031.00e+007.231115
GO:1901741positive regulation of myoblast fusion6.64e-031.00e+007.231115
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-proline6.64e-031.00e+007.231115
GO:2000323negative regulation of glucocorticoid receptor signaling pathway6.64e-031.00e+007.231115
GO:0002161aminoacyl-tRNA editing activity6.64e-031.00e+007.231115
GO:0050847progesterone receptor signaling pathway7.96e-031.00e+006.968126
GO:0002181cytoplasmic translation7.96e-031.00e+006.968116
GO:0001055RNA polymerase II activity7.96e-031.00e+006.968136
GO:0043297apical junction assembly7.96e-031.00e+006.968116
GO:0070937CRD-mediated mRNA stability complex7.96e-031.00e+006.968126
GO:0006903vesicle targeting7.96e-031.00e+006.968116
GO:0010831positive regulation of myotube differentiation7.96e-031.00e+006.968116
GO:0003756protein disulfide isomerase activity9.28e-031.00e+006.746117
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway9.28e-031.00e+006.746117
GO:0004707MAP kinase activity9.28e-031.00e+006.746117
GO:0042581specific granule9.28e-031.00e+006.746117
GO:0003924GTPase activity1.05e-021.00e+003.65827119
GO:0090307spindle assembly involved in mitosis1.06e-021.00e+006.553128
GO:0004708MAP kinase kinase activity1.06e-021.00e+006.553128
GO:0006450regulation of translational fidelity1.06e-021.00e+006.553118
GO:0010944negative regulation of transcription by competitive promoter binding1.06e-021.00e+006.553118
GO:0019395fatty acid oxidation1.06e-021.00e+006.553118
GO:0010388cullin deneddylation1.06e-021.00e+006.553148
GO:0043296apical junction complex1.06e-021.00e+006.553118
GO:0032495response to muramyl dipeptide1.06e-021.00e+006.553118
GO:0045663positive regulation of myoblast differentiation1.19e-021.00e+006.383129
GO:0071354cellular response to interleukin-61.19e-021.00e+006.383119
GO:0006184GTP catabolic process1.25e-021.00e+003.53127130
GO:0070062extracellular vesicular exosome1.31e-021.00e+001.4586511641
GO:0005736DNA-directed RNA polymerase I complex1.32e-021.00e+006.2311410
GO:0005095GTPase inhibitor activity1.32e-021.00e+006.2311110
GO:0050919negative chemotaxis1.32e-021.00e+006.2311110
GO:0001054RNA polymerase I activity1.32e-021.00e+006.2311410
GO:0030168platelet activation1.45e-021.00e+003.41325141
GO:0060766negative regulation of androgen receptor signaling pathway1.46e-021.00e+006.0941411
GO:00709353'-UTR-mediated mRNA stabilization1.46e-021.00e+006.0941111
GO:0042770signal transduction in response to DNA damage1.46e-021.00e+006.0941111
GO:0042307positive regulation of protein import into nucleus1.59e-021.00e+005.9681312
GO:0006349regulation of gene expression by genetic imprinting1.59e-021.00e+005.9681112
GO:0051146striated muscle cell differentiation1.59e-021.00e+005.9681112
GO:0061025membrane fusion1.72e-021.00e+005.8531113
GO:0050772positive regulation of axonogenesis1.72e-021.00e+005.8531213
GO:0050770regulation of axonogenesis1.72e-021.00e+005.8531313
GO:0005666DNA-directed RNA polymerase III complex1.72e-021.00e+005.8531313
GO:0005665DNA-directed RNA polymerase II, core complex1.72e-021.00e+005.8531313
GO:0001056RNA polymerase III activity1.72e-021.00e+005.8531313
GO:0001502cartilage condensation1.72e-021.00e+005.8531213
GO:0042346positive regulation of NF-kappaB import into nucleus1.72e-021.00e+005.8531113
GO:0006386termination of RNA polymerase III transcription1.85e-021.00e+005.7461314
GO:0006385transcription elongation from RNA polymerase III promoter1.85e-021.00e+005.7461314
GO:0050771negative regulation of axonogenesis1.85e-021.00e+005.7461214
GO:0043536positive regulation of blood vessel endothelial cell migration1.85e-021.00e+005.7461114
GO:0016575histone deacetylation1.85e-021.00e+005.7461214
GO:0008135translation factor activity, nucleic acid binding1.98e-021.00e+005.6461415
GO:0000188inactivation of MAPK activity1.98e-021.00e+005.6461115
GO:0048010vascular endothelial growth factor receptor signaling pathway2.11e-021.00e+005.5531116
GO:0032467positive regulation of cytokinesis2.11e-021.00e+005.5531116
GO:0017022myosin binding2.11e-021.00e+005.5531216
GO:0045648positive regulation of erythrocyte differentiation2.24e-021.00e+005.4661217
GO:0003899DNA-directed RNA polymerase activity2.37e-021.00e+005.3831318
GO:0051090regulation of sequence-specific DNA binding transcription factor activity2.37e-021.00e+005.3831218
GO:0030316osteoclast differentiation2.37e-021.00e+005.3831118
GO:0035924cellular response to vascular endothelial growth factor stimulus2.37e-021.00e+005.3831118
GO:0036464cytoplasmic ribonucleoprotein granule2.50e-021.00e+005.3051119
GO:0071897DNA biosynthetic process2.63e-021.00e+005.2311220
GO:0005525GTP binding2.73e-021.00e+002.931212197
GO:0000077DNA damage checkpoint2.76e-021.00e+005.1611421
GO:2000379positive regulation of reactive oxygen species metabolic process2.76e-021.00e+005.1611121
GO:0048011neurotrophin TRK receptor signaling pathway2.78e-021.00e+002.91628199
GO:0051149positive regulation of muscle cell differentiation2.89e-021.00e+005.0941222
GO:0002062chondrocyte differentiation2.89e-021.00e+005.0941222
GO:0019899enzyme binding3.07e-021.00e+002.83927210
GO:0003677DNA binding3.08e-021.00e+001.666452947
GO:00063707-methylguanosine mRNA capping3.15e-021.00e+004.9681524
GO:0008180COP9 signalosome3.15e-021.00e+004.9681624
GO:0071479cellular response to ionizing radiation3.15e-021.00e+004.9681224
GO:0005634nucleus3.40e-021.00e+000.88981583246
GO:0051496positive regulation of stress fiber assembly3.41e-021.00e+004.8531226
GO:0006360transcription from RNA polymerase I promoter3.54e-021.00e+004.7981427
GO:0031663lipopolysaccharide-mediated signaling pathway3.54e-021.00e+004.7981127
GO:0005737cytoplasm3.61e-021.00e+000.99871272633
GO:0042692muscle cell differentiation3.67e-021.00e+004.7461228
GO:0006418tRNA aminoacylation for protein translation3.79e-021.00e+004.6951429
GO:0006383transcription from RNA polymerase III promoter3.79e-021.00e+004.6951629
GO:0032154cleavage furrow3.92e-021.00e+004.6461330
GO:0034976response to endoplasmic reticulum stress4.05e-021.00e+004.5991231
GO:0045454cell redox homeostasis4.05e-021.00e+004.5991331
GO:0003723RNA binding4.14e-021.00e+002.605222247
GO:0042157lipoprotein metabolic process4.18e-021.00e+004.5531432
GO:0006892post-Golgi vesicle-mediated transport4.18e-021.00e+004.5531132
GO:0007519skeletal muscle tissue development4.31e-021.00e+004.5091233
GO:0021762substantia nigra development4.44e-021.00e+004.4661134
GO:0007254JNK cascade4.44e-021.00e+004.4661134
GO:0000902cell morphogenesis4.56e-021.00e+004.4241535
GO:0050434positive regulation of viral transcription4.56e-021.00e+004.4241535
GO:0007266Rho protein signal transduction4.56e-021.00e+004.4241235
GO:0030334regulation of cell migration4.69e-021.00e+004.3831236
GO:0003743translation initiation factor activity4.82e-021.00e+004.3441837
GO:0005793endoplasmic reticulum-Golgi intermediate compartment4.95e-021.00e+004.3051238
GO:0006396RNA processing5.20e-021.00e+004.2311440
GO:0006283transcription-coupled nucleotide-excision repair5.20e-021.00e+004.2311640
GO:0005739mitochondrion5.26e-021.00e+001.774332659
GO:0051403stress-activated MAPK cascade5.45e-021.00e+004.1611242
GO:0006887exocytosis5.71e-021.00e+004.0941144
GO:0032481positive regulation of type I interferon production6.21e-021.00e+003.9681348
GO:0034146toll-like receptor 5 signaling pathway6.46e-021.00e+003.9091350
GO:0034166toll-like receptor 10 signaling pathway6.46e-021.00e+003.9091350
GO:0018105peptidyl-serine phosphorylation6.58e-021.00e+003.8811251
GO:0006368transcription elongation from RNA polymerase II promoter6.71e-021.00e+003.8531852
GO:0006289nucleotide-excision repair6.83e-021.00e+003.8251653
GO:0045666positive regulation of neuron differentiation6.83e-021.00e+003.8251353
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway7.08e-021.00e+003.7721355
GO:0034162toll-like receptor 9 signaling pathway7.08e-021.00e+003.7721355
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway7.08e-021.00e+003.7721355
GO:0005829cytosol7.21e-021.00e+001.0725881787
GO:0034134toll-like receptor 2 signaling pathway7.21e-021.00e+003.7461356
GO:0007596blood coagulation7.28e-021.00e+002.148213339
GO:0035666TRIF-dependent toll-like receptor signaling pathway7.33e-021.00e+003.7201257
GO:0042826histone deacetylase binding7.46e-021.00e+003.6951558
GO:0006935chemotaxis7.46e-021.00e+003.6951258
GO:0002756MyD88-independent toll-like receptor signaling pathway7.46e-021.00e+003.6951258
GO:0034138toll-like receptor 3 signaling pathway7.58e-021.00e+003.6701259
GO:0090090negative regulation of canonical Wnt signaling pathway7.58e-021.00e+003.6701559
GO:0007265Ras protein signal transduction7.58e-021.00e+003.6701359
GO:0071013catalytic step 2 spliceosome7.83e-021.00e+003.6221561
GO:0002755MyD88-dependent toll-like receptor signaling pathway7.83e-021.00e+003.6221461
GO:0000187activation of MAPK activity8.07e-021.00e+003.5761363
GO:0042470melanosome8.20e-021.00e+003.5531364
GO:0071222cellular response to lipopolysaccharide8.20e-021.00e+003.5531264
GO:0044822poly(A) RNA binding8.42e-021.00e+001.496345799
GO:0000922spindle pole8.69e-021.00e+003.4661468
GO:0006928cellular component movement8.93e-021.00e+003.4241670
GO:0030308negative regulation of cell growth8.93e-021.00e+003.4241370
GO:0030496midbody9.30e-021.00e+003.3631673
GO:0034142toll-like receptor 4 signaling pathway9.30e-021.00e+003.3631373
GO:0051056regulation of small GTPase mediated signal transduction9.66e-021.00e+003.3051276
GO:0071456cellular response to hypoxia9.66e-021.00e+003.3051276
GO:0005938cell cortex9.79e-021.00e+003.2861677
GO:0006006glucose metabolic process1.01e-011.00e+003.2311380
GO:0030529ribonucleoprotein complex1.04e-011.00e+003.1951582
GO:0048015phosphatidylinositol-mediated signaling1.05e-011.00e+003.1781283
GO:0045202synapse1.05e-011.00e+003.1781383
GO:0002224toll-like receptor signaling pathway1.05e-011.00e+003.1781383
GO:0005524ATP binding1.09e-011.00e+001.337337892
GO:0016032viral process1.09e-011.00e+001.811230428
GO:0030027lamellipodium1.11e-011.00e+003.0941388
GO:0007166cell surface receptor signaling pathway1.12e-011.00e+003.0771389
GO:0061024membrane organization1.12e-011.00e+003.0771289
GO:0030036actin cytoskeleton organization1.13e-011.00e+003.0611490
GO:0045087innate immune response1.19e-011.00e+001.733212452
GO:0006457protein folding1.22e-011.00e+002.9531597
GO:0006413translational initiation1.24e-011.00e+002.9241699
GO:0005788endoplasmic reticulum lumen1.30e-011.00e+002.85314104
GO:0007179transforming growth factor beta receptor signaling pathway1.34e-011.00e+002.81115107
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling1.35e-011.00e+002.79812108
GO:0042981regulation of apoptotic process1.39e-011.00e+002.74614112
GO:0043005neuron projection1.41e-011.00e+002.73316113
GO:0007049cell cycle1.43e-011.00e+002.70718115
GO:0044212transcription regulatory region DNA binding1.75e-011.00e+002.393113143
GO:0001525angiogenesis1.78e-011.00e+002.36312146
GO:0006367transcription initiation from RNA polymerase II promoter1.94e-011.00e+002.222118161
GO:0007165signal transduction1.97e-011.00e+001.282224618
GO:0016071mRNA metabolic process2.04e-011.00e+002.144110170
GO:0007264small GTPase mediated signal transduction2.09e-011.00e+002.11018174
GO:0000166nucleotide binding2.11e-011.00e+002.094113176
GO:0006412translation2.13e-011.00e+002.077112178
GO:0005575cellular_component2.22e-011.00e+002.00614187
GO:0016070RNA metabolic process2.23e-011.00e+001.998110188
GO:0005856cytoskeleton2.26e-011.00e+001.98318190
GO:0005743mitochondrial inner membrane2.33e-011.00e+001.93119197
GO:0004674protein serine/threonine kinase activity2.33e-011.00e+001.93118197
GO:0035556intracellular signal transduction2.35e-011.00e+001.91615199
GO:0015031protein transport2.39e-011.00e+001.888110203
GO:0006357regulation of transcription from RNA polymerase II promoter2.39e-011.00e+001.888114203
GO:0006281DNA repair2.39e-011.00e+001.888124203
GO:0006355regulation of transcription, DNA-templated2.46e-011.00e+001.071231715
GO:0030054cell junction2.54e-011.00e+001.78515218
GO:0030198extracellular matrix organization2.58e-011.00e+001.76517221
GO:0007411axon guidance2.74e-011.00e+001.66418237
GO:0046982protein heterodimerization activity3.01e-011.00e+001.503111265
GO:0008150biological_process3.06e-011.00e+001.47613270
GO:0008285negative regulation of cell proliferation3.12e-011.00e+001.439111277
GO:0009986cell surface3.25e-011.00e+001.36815291
GO:0003674molecular_function3.31e-011.00e+001.33914297
GO:0045892negative regulation of transcription, DNA-templated3.49e-011.00e+001.245117317
GO:0006366transcription from RNA polymerase II promoter3.70e-011.00e+001.139123341
GO:0044267cellular protein metabolic process3.80e-011.00e+001.094114352
GO:0042802identical protein binding3.81e-011.00e+001.085115354
GO:0045893positive regulation of transcription, DNA-templated4.01e-011.00e+000.995121377
GO:0005783endoplasmic reticulum4.04e-011.00e+000.979112381
GO:0006915apoptotic process4.28e-011.00e+000.870115411
GO:0006351transcription, DNA-templated4.28e-011.00e+000.4822471076
GO:0005886plasma membrane4.33e-011.00e+000.3373461784
GO:0000122negative regulation of transcription from RNA polymerase II promoter4.63e-011.00e+000.720129456
GO:0016020membrane4.90e-011.00e+000.3162561207
GO:0005730nucleolus4.95e-011.00e+000.3042741217
GO:0005887integral component of plasma membrane5.46e-011.00e+000.38618575
GO:0045944positive regulation of transcription from RNA polymerase II promoter5.88e-011.00e+000.222129644
GO:0005576extracellular region5.99e-011.00e+000.180115663
GO:0008270zinc ion binding6.34e-011.00e+000.047139727
GO:0044281small molecule metabolic process6.91e-011.00e+00-0.168135844