reg-snw-3145

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.226 2.10e-07 3.98e-02 3.04e-02
chia-screen-data-Fav-reg-snw-3145 subnetwork

Genes (23)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Transcription factor Chia-Hits Primary Chia-Hits Secondary
NDUFA4L2 56901 44-2.4772.45921-Yes-
ANAPC5 51433 2-1.2642.263239TF--
CENPA 1058 27-2.1852.393205TFYes-
CNOT1 23019 4-2.3472.26334-Yes-
PHB2 11331 17-2.2362.44911-Yes-
PHB 5245 82-2.7432.68936-YesYes
REXO4 57109 5-1.7432.28795TF--
MED13L 23389 3-2.5502.30729-Yes-
FBXL6 26233 28-2.2532.68922-Yes-
SUV39H2 79723 27-2.3072.41021-YesYes
COPS3 8533 8-1.8732.43579TF--
SNAP23 8773 4-2.0732.43015-Yes-
POLR2E 5434 30-2.0372.644201TFYes-
CCT7 10574 40-2.3352.45938-Yes-
[ HMBS ] 3145 1-1.1172.22622---
CLPP 8192 4-2.2002.29110-Yes-
EIF2B3 8891 8-2.5462.4354-YesYes
COPS6 10980 4-1.7652.39318TF--
HNRNPU 3192 39-2.8692.64433-Yes-
ZNRD1 30834 3-1.3752.226106TF--
GPS1 2873 86-3.6212.68936TFYesYes
FUBP1 8880 5-2.4142.38918TFYesYes
TMEM14B 81853 3-2.8792.2261-YesYes

Interactions (28)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
POLR2E 5434 SNAP23 8773 pd > reg.ITFP.txt: no annot
HMBS 3145 REXO4 57109 pd < reg.ITFP.txt: no annot
CENPA 1058 FBXL6 26233 pd > reg.ITFP.txt: no annot
CCT7 10574 ZNRD1 30834 pd < reg.ITFP.txt: no annot
CENPA 1058 ZNRD1 30834 pd <> reg.ITFP.txt: no annot
ZNRD1 30834 TMEM14B 81853 pd > reg.ITFP.txt: no annot
CNOT1 23019 ANAPC5 51433 pd < reg.ITFP.txt: no annot
POLR2E 5434 ANAPC5 51433 pd <> reg.ITFP.txt: no annot
HNRNPU 3192 POLR2E 5434 pd < reg.ITFP.txt: no annot
GPS1 2873 CLPP 8192 pd > reg.ITFP.txt: no annot
CENPA 1058 SUV39H2 79723 pd > reg.ITFP.txt: no annot
CCT7 10574 REXO4 57109 pd < reg.ITFP.txt: no annot
PHB 5245 ZNRD1 30834 pd < reg.ITFP.txt: no annot
MED13L 23389 ANAPC5 51433 pd < reg.ITFP.txt: no annot
HNRNPU 3192 ANAPC5 51433 pd < reg.ITFP.txt: no annot
HMBS 3145 COPS6 10980 pd < reg.ITFP.txt: no annot
SNAP23 8773 ANAPC5 51433 pd < reg.ITFP.txt: no annot
CLPP 8192 COPS6 10980 pd < reg.ITFP.txt: no annot
HMBS 3145 ZNRD1 30834 pd < reg.ITFP.txt: no annot
HMBS 3145 COPS3 8533 pd < reg.ITFP.txt: no annot
GPS1 2873 PHB 5245 pd > reg.ITFP.txt: no annot
HMBS 3145 ANAPC5 51433 pd < reg.ITFP.txt: no annot
FUBP1 8880 ANAPC5 51433 pd <> reg.ITFP.txt: no annot
COPS3 8533 EIF2B3 8891 pd > reg.ITFP.txt: no annot
PHB2 11331 ZNRD1 30834 pd < reg.ITFP.txt: no annot
CENPA 1058 HMBS 3145 pd > reg.ITFP.txt: no annot
CENPA 1058 NDUFA4L2 56901 pd > reg.ITFP.txt: no annot
GPS1 2873 PHB2 11331 pd > reg.ITFP.txt: no annot

Related GO terms (203)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0010388cullin deneddylation6.34e-076.19e-037.315348
GO:0008180COP9 signalosome2.24e-052.18e-015.7303624
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway1.11e-041.00e+006.922227
GO:0005736DNA-directed RNA polymerase I complex2.36e-041.00e+006.4082410
GO:0001054RNA polymerase I activity2.36e-041.00e+006.4082410
GO:0030331estrogen receptor binding1.19e-031.00e+005.2702222
GO:0018160peptidyl-pyrromethane cofactor linkage2.36e-031.00e+008.730111
GO:0000939condensed chromosome inner kinetochore2.36e-031.00e+008.730111
GO:0004418hydroxymethylbilane synthase activity2.36e-031.00e+008.730111
GO:0000775chromosome, centromeric region4.12e-031.00e+004.3722641
GO:0051716cellular response to stimulus4.71e-031.00e+007.730112
GO:0009368endopeptidase Clp complex4.71e-031.00e+007.730112
GO:0036123histone H3-K9 dimethylation7.05e-031.00e+007.145113
GO:0000778condensed nuclear chromosome kinetochore7.05e-031.00e+007.145123
GO:0071459protein localization to chromosome, centromeric region7.05e-031.00e+007.145113
GO:0010606positive regulation of cytoplasmic mRNA processing body assembly7.05e-031.00e+007.145113
GO:0042582azurophil granule9.39e-031.00e+006.730114
GO:0032057negative regulation of translational initiation in response to stress9.39e-031.00e+006.730114
GO:0036124histone H3-K9 trimethylation9.39e-031.00e+006.730124
GO:0006333chromatin assembly or disassembly9.39e-031.00e+006.730114
GO:0005851eukaryotic translation initiation factor 2B complex9.39e-031.00e+006.730124
GO:0016779nucleotidyltransferase activity9.39e-031.00e+006.730114
GO:0060762regulation of branching involved in mammary gland duct morphogenesis9.39e-031.00e+006.730114
GO:0070934CRD-mediated mRNA stabilization1.17e-021.00e+006.408125
GO:0033600negative regulation of mammary gland epithelial cell proliferation1.17e-021.00e+006.408115
GO:0060744mammary gland branching involved in thelarche1.17e-021.00e+006.408115
GO:2000323negative regulation of glucocorticoid receptor signaling pathway1.17e-021.00e+006.408115
GO:0001649osteoblast differentiation1.29e-021.00e+003.5202574
GO:0050847progesterone receptor signaling pathway1.41e-021.00e+006.145126
GO:0001055RNA polymerase II activity1.41e-021.00e+006.145136
GO:0042754negative regulation of circadian rhythm1.41e-021.00e+006.145126
GO:0046974histone methyltransferase activity (H3-K9 specific)1.41e-021.00e+006.145116
GO:0070937CRD-mediated mRNA stability complex1.41e-021.00e+006.145126
GO:0006903vesicle targeting1.41e-021.00e+006.145116
GO:0002199zona pellucida receptor complex1.64e-021.00e+005.922147
GO:0007140male meiosis1.64e-021.00e+005.922117
GO:0000780condensed nuclear chromosome, centromeric region1.64e-021.00e+005.922117
GO:0005832chaperonin-containing T-complex1.64e-021.00e+005.922147
GO:0006782protoporphyrinogen IX biosynthetic process1.64e-021.00e+005.922127
GO:0051382kinetochore assembly1.64e-021.00e+005.922127
GO:0042581specific granule1.64e-021.00e+005.922117
GO:0004535poly(A)-specific ribonuclease activity1.87e-021.00e+005.730118
GO:0010944negative regulation of transcription by competitive promoter binding1.87e-021.00e+005.730118
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay1.87e-021.00e+005.730118
GO:0071354cellular response to interleukin-62.10e-021.00e+005.560119
GO:0048387negative regulation of retinoic acid receptor signaling pathway2.10e-021.00e+005.560129
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening2.10e-021.00e+005.560119
GO:0005515protein binding2.21e-021.00e+000.627151984124
GO:0005095GTPase inhibitor activity2.33e-021.00e+005.4081110
GO:0042974retinoic acid receptor binding2.33e-021.00e+005.4081110
GO:0009416response to light stimulus2.33e-021.00e+005.4081110
GO:0030014CCR4-NOT complex2.33e-021.00e+005.4081110
GO:0060766negative regulation of androgen receptor signaling pathway2.56e-021.00e+005.2701411
GO:2000036regulation of stem cell maintenance2.56e-021.00e+005.2701111
GO:0006783heme biosynthetic process2.56e-021.00e+005.2701211
GO:0000132establishment of mitotic spindle orientation2.79e-021.00e+005.1451212
GO:0004527exonuclease activity2.79e-021.00e+005.1451412
GO:0051603proteolysis involved in cellular protein catabolic process2.79e-021.00e+005.1451112
GO:0006778porphyrin-containing compound metabolic process2.79e-021.00e+005.1451212
GO:0061025membrane fusion3.02e-021.00e+005.0291113
GO:0005680anaphase-promoting complex3.02e-021.00e+005.0291213
GO:0005666DNA-directed RNA polymerase III complex3.02e-021.00e+005.0291313
GO:0005665DNA-directed RNA polymerase II, core complex3.02e-021.00e+005.0291313
GO:0001056RNA polymerase III activity3.02e-021.00e+005.0291313
GO:0060749mammary gland alveolus development3.02e-021.00e+005.0291113
GO:0006386termination of RNA polymerase III transcription3.25e-021.00e+004.9221314
GO:0006385transcription elongation from RNA polymerase III promoter3.25e-021.00e+004.9221314
GO:0016575histone deacetylation3.25e-021.00e+004.9221214
GO:0010467gene expression3.44e-021.00e+001.666449535
GO:0008135translation factor activity, nucleic acid binding3.48e-021.00e+004.8231415
GO:0000188inactivation of MAPK activity3.48e-021.00e+004.8231115
GO:0014003oligodendrocyte development3.48e-021.00e+004.8231115
GO:0007339binding of sperm to zona pellucida3.48e-021.00e+004.8231415
GO:0000398mRNA splicing, via spliceosome3.60e-021.00e+002.730215128
GO:0045892negative regulation of transcription, DNA-templated3.71e-021.00e+002.006317317
GO:0001829trophectodermal cell differentiation3.93e-021.00e+004.6421217
GO:0003899DNA-directed RNA polymerase activity4.16e-021.00e+004.5601318
GO:0031047gene silencing by RNA4.16e-021.00e+004.5601218
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic4.39e-021.00e+004.4821119
GO:0036464cytoplasmic ribonucleoprotein granule4.39e-021.00e+004.4821119
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription4.39e-021.00e+004.4821119
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening4.39e-021.00e+004.4821119
GO:0006366transcription from RNA polymerase II promoter4.46e-021.00e+001.901323341
GO:0034080CENP-A containing nucleosome assembly4.61e-021.00e+004.4081220
GO:0070979protein K11-linked ubiquitination4.61e-021.00e+004.4081320
GO:0005720nuclear heterochromatin4.61e-021.00e+004.4081320
GO:0071897DNA biosynthetic process4.61e-021.00e+004.4081220
GO:0005634nucleus4.69e-021.00e+000.650121583246
GO:0006363termination of RNA polymerase I transcription4.84e-021.00e+004.3381321
GO:0005654nucleoplasm4.96e-021.00e+001.277568876
GO:0006139nucleobase-containing compound metabolic process5.06e-021.00e+004.2701222
GO:0051084'de novo' posttranslational protein folding5.06e-021.00e+004.2701422
GO:00063707-methylguanosine mRNA capping5.51e-021.00e+004.1451524
GO:0001104RNA polymerase II transcription cofactor activity5.51e-021.00e+004.1451424
GO:0008380RNA splicing5.69e-021.00e+002.364221165
GO:0016592mediator complex5.73e-021.00e+004.0861625
GO:0007094mitotic spindle assembly checkpoint5.73e-021.00e+004.0861425
GO:0000976transcription regulatory region sequence-specific DNA binding5.73e-021.00e+004.0861325
GO:0006360transcription from RNA polymerase I promoter6.18e-021.00e+003.9751427
GO:0008233peptidase activity6.40e-021.00e+003.9221228
GO:0005739mitochondrion6.54e-021.00e+001.366432659
GO:0006383transcription from RNA polymerase III promoter6.62e-021.00e+003.8721629
GO:0005778peroxisomal membrane6.62e-021.00e+003.8721329
GO:0009408response to heat7.06e-021.00e+003.7761131
GO:0090305nucleic acid phosphodiester bond hydrolysis7.06e-021.00e+003.7761631
GO:0006892post-Golgi vesicle-mediated transport7.28e-021.00e+003.7301132
GO:0000786nucleosome7.72e-021.00e+003.6421234
GO:0007254JNK cascade7.72e-021.00e+003.6421134
GO:0016032viral process7.74e-021.00e+001.573330428
GO:0005743mitochondrial inner membrane7.77e-021.00e+002.10829197
GO:0050434positive regulation of viral transcription7.94e-021.00e+003.6011535
GO:0044297cell body7.94e-021.00e+003.6011535
GO:0043434response to peptide hormone8.15e-021.00e+003.5601136
GO:0003743translation initiation factor activity8.37e-021.00e+003.5201837
GO:0048511rhythmic process8.59e-021.00e+003.4821538
GO:0006417regulation of translation8.80e-021.00e+003.4441239
GO:0000122negative regulation of transcription from RNA polymerase II promoter8.97e-021.00e+001.482329456
GO:0006396RNA processing9.02e-021.00e+003.4081440
GO:0006283transcription-coupled nucleotide-excision repair9.02e-021.00e+003.4081640
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay9.02e-021.00e+003.4081440
GO:0005085guanyl-nucleotide exchange factor activity9.66e-021.00e+003.3041243
GO:0000932cytoplasmic mRNA processing body9.66e-021.00e+003.3041343
GO:0006887exocytosis9.88e-021.00e+003.2701144
GO:0009749response to glucose1.01e-011.00e+003.2381145
GO:0019903protein phosphatase binding1.05e-011.00e+003.1751247
GO:0032481positive regulation of type I interferon production1.07e-011.00e+003.1451348
GO:0005829cytosol1.12e-011.00e+000.7347881787
GO:0006334nucleosome assembly1.14e-011.00e+003.0571451
GO:0044822poly(A) RNA binding1.14e-011.00e+001.088445799
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.16e-011.00e+003.0291352
GO:0006368transcription elongation from RNA polymerase II promoter1.16e-011.00e+003.0291852
GO:0006289nucleotide-excision repair1.18e-011.00e+003.0021653
GO:0003682chromatin binding1.18e-011.00e+001.753215252
GO:0006338chromatin remodeling1.22e-011.00e+002.9481755
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.24e-011.00e+002.9221556
GO:0003697single-stranded DNA binding1.26e-011.00e+002.8971457
GO:0042826histone deacetylase binding1.28e-011.00e+002.8721558
GO:0000785chromatin1.30e-011.00e+002.8471659
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.32e-011.00e+002.8231560
GO:0071013catalytic step 2 spliceosome1.34e-011.00e+002.7991561
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.43e-011.00e+002.7071765
GO:0003676nucleic acid binding1.45e-011.00e+002.6851466
GO:0005730nucleolus1.50e-011.00e+000.8035741217
GO:0030308negative regulation of cell growth1.53e-011.00e+002.6011370
GO:0051082unfolded protein binding1.53e-011.00e+002.6011570
GO:0016363nuclear matrix1.59e-011.00e+002.54011073
GO:0071456cellular response to hypoxia1.65e-011.00e+002.4821276
GO:0000278mitotic cell cycle1.68e-011.00e+001.435228314
GO:0004252serine-type endopeptidase activity1.69e-011.00e+002.4441178
GO:0030529ribonucleoprotein complex1.76e-011.00e+002.3721582
GO:0045202synapse1.78e-011.00e+002.3551383
GO:0051260protein homooligomerization1.86e-011.00e+002.2871287
GO:0061024membrane organization1.90e-011.00e+002.2541289
GO:0044267cellular protein metabolic process2.00e-011.00e+001.270214352
GO:0042802identical protein binding2.02e-011.00e+001.262215354
GO:0006457protein folding2.05e-011.00e+002.1301597
GO:0006413translational initiation2.09e-011.00e+002.1001699
GO:0010628positive regulation of gene expression2.22e-011.00e+002.00212106
GO:0043547positive regulation of GTPase activity2.33e-011.00e+001.92212112
GO:0042981regulation of apoptotic process2.33e-011.00e+001.92214112
GO:0043005neuron projection2.35e-011.00e+001.91016113
GO:0007049cell cycle2.39e-011.00e+001.88418115
GO:0005759mitochondrial matrix2.81e-011.00e+001.61117139
GO:0044212transcription regulatory region DNA binding2.88e-011.00e+001.570113143
GO:0001701in utero embryonic development3.07e-011.00e+001.46317154
GO:0006367transcription initiation from RNA polymerase II promoter3.18e-011.00e+001.399118161
GO:0005874microtubule3.21e-011.00e+001.381110163
GO:0007067mitotic nuclear division3.25e-011.00e+001.36419165
GO:0016071mRNA metabolic process3.33e-011.00e+001.320110170
GO:0070062extracellular vesicular exosome3.42e-011.00e+000.3715511641
GO:0006412translation3.45e-011.00e+001.254112178
GO:0004842ubiquitin-protein transferase activity3.47e-011.00e+001.246117179
GO:0016567protein ubiquitination3.61e-011.00e+001.175114188
GO:0016070RNA metabolic process3.61e-011.00e+001.175110188
GO:0015031protein transport3.84e-011.00e+001.065110203
GO:0006357regulation of transcription from RNA polymerase II promoter3.84e-011.00e+001.065114203
GO:0006281DNA repair3.84e-011.00e+001.065124203
GO:0030154cell differentiation3.85e-011.00e+001.05715204
GO:0003677DNA binding3.89e-011.00e+000.428352947
GO:0043234protein complex3.94e-011.00e+001.016113210
GO:0019899enzyme binding3.94e-011.00e+001.01617210
GO:0003700sequence-specific DNA binding transcription factor activity4.02e-011.00e+000.545222582
GO:0005737cytoplasm4.30e-011.00e+000.17571272633
GO:0007165signal transduction4.32e-011.00e+000.458224618
GO:0003723RNA binding4.46e-011.00e+000.781122247
GO:0006508proteolysis4.68e-011.00e+000.685111264
GO:0046982protein heterodimerization activity4.69e-011.00e+000.680111265
GO:0006351transcription, DNA-templated4.73e-011.00e+000.2433471076
GO:0008285negative regulation of cell proliferation4.85e-011.00e+000.616111277
GO:0005925focal adhesion4.91e-011.00e+000.590114282
GO:0009986cell surface5.02e-011.00e+000.54515291
GO:0006355regulation of transcription, DNA-templated5.10e-011.00e+000.248231715
GO:0008270zinc ion binding5.19e-011.00e+000.224239727
GO:0016020membrane5.54e-011.00e+000.0783561207
GO:0045893positive regulation of transcription, DNA-templated5.96e-011.00e+000.171121377
GO:0005524ATP binding6.34e-011.00e+00-0.071237892
GO:0045087innate immune response6.64e-011.00e+00-0.090112452
GO:0005887integral component of plasma membrane7.53e-011.00e+00-0.43818575
GO:0045944positive regulation of transcription from RNA polymerase II promoter7.92e-011.00e+00-0.601129644
GO:0005615extracellular space7.96e-011.00e+00-0.617115651
GO:0044281small molecule metabolic process8.75e-011.00e+00-0.991135844
GO:0016021integral component of membrane9.80e-011.00e+00-1.8461191526
GO:0005886plasma membrane9.90e-011.00e+00-2.0711461784