int-snw-6688

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.870 6.97e-16 3.17e-04 2.51e-03
chia-screen-data-Fav-int-snw-6688 subnetwork

Genes (9)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
EMX1 2016 4-2.3693.21619Yes-
FTL 2512 2-2.3962.92225YesYes
KDM4B 23030 5-3.8923.2165Yes-
CDC42 998 9-2.1993.119265YesYes
NFKB1 4790 9-2.1232.870263Yes-
NFRKB 4798 48-3.1293.10823YesYes
POU5F1 5460 133-5.1483.538179YesYes
YY1 7528 24-2.5723.120114YesYes
[ SPI1 ] 6688 2-2.0032.870115YesYes

Interactions (11)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CDC42 998 SPI1 6688 pp -- int.I2D: INNATEDB_Mouse
NFRKB 4798 YY1 7528 pp -- int.I2D: BioGrid
FTL 2512 SPI1 6688 pp -- int.I2D: IntAct
NFKB1 4790 SPI1 6688 pp -- int.I2D: HPRD, BCI;
int.Ravasi: -;
int.HPRD: in vitro
NFKB1 4790 YY1 7528 pp -- int.Intact: MI:0915(physical association)
EMX1 2016 KDM4B 23030 pp -- int.I2D: BioGrid_Mouse
NFRKB 4798 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
NFKB1 4790 NFRKB 4798 pp -- int.I2D: BCI, HPRD;
int.Ravasi: -;
int.HPRD: in vitro
SPI1 6688 YY1 7528 pp -- int.Mysickova: lymph_node
EMX1 2016 SPI1 6688 pp -- int.I2D: BioGrid_Mouse
POU5F1 5460 SPI1 6688 pp -- int.Mysickova: lymph_node

Related GO terms (240)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0031011Ino80 complex3.14e-054.53e-017.8392614
GO:0030225macrophage differentiation3.62e-055.22e-017.7392215
GO:0006366transcription from RNA polymerase II promoter7.88e-051.00e+003.935430419
GO:0044212transcription regulatory region DNA binding1.24e-041.00e+004.839317168
GO:0035019somatic stem cell maintenance2.67e-041.00e+006.3242640
GO:0003700sequence-specific DNA binding transcription factor activity5.67e-041.00e+003.197439699
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription5.81e-041.00e+005.7642559
GO:0060795cell fate commitment involved in formation of primary germ layer6.24e-041.00e+0010.646111
GO:0045083negative regulation of interleukin-12 biosynthetic process6.24e-041.00e+0010.646111
GO:0090308regulation of methylation-dependent chromatin silencing6.24e-041.00e+0010.646111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway6.24e-041.00e+0010.646111
GO:0060965negative regulation of gene silencing by miRNA6.24e-041.00e+0010.646111
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity9.13e-041.00e+005.4372474
GO:0034696response to prostaglandin F1.25e-031.00e+009.646112
GO:0008043intracellular ferritin complex1.25e-031.00e+009.646112
GO:0071338positive regulation of hair follicle cell proliferation1.25e-031.00e+009.646112
GO:0090241negative regulation of histone H4 acetylation1.25e-031.00e+009.646122
GO:0006403RNA localization1.25e-031.00e+009.646112
GO:0090135actin filament branching1.25e-031.00e+009.646112
GO:0009786regulation of asymmetric cell division1.25e-031.00e+009.646112
GO:0060661submandibular salivary gland formation1.25e-031.00e+009.646112
GO:0033256I-kappaB/NF-kappaB complex1.87e-031.00e+009.061113
GO:0051683establishment of Golgi localization1.87e-031.00e+009.061113
GO:0044027hypermethylation of CpG island1.87e-031.00e+009.061113
GO:0034191apolipoprotein A-I receptor binding1.87e-031.00e+009.061113
GO:0060913cardiac cell fate determination1.87e-031.00e+009.061113
GO:0003130BMP signaling pathway involved in heart induction1.87e-031.00e+009.061113
GO:0003161cardiac conduction system development1.87e-031.00e+009.061113
GO:1900127positive regulation of hyaluronan biosynthetic process1.87e-031.00e+009.061113
GO:0010956negative regulation of calcidiol 1-monooxygenase activity1.87e-031.00e+009.061113
GO:0006355regulation of transcription, DNA-templated2.16e-031.00e+002.685443997
GO:0010957negative regulation of vitamin D biosynthetic process2.49e-031.00e+008.646114
GO:0032375negative regulation of cholesterol transport2.49e-031.00e+008.646114
GO:0045646regulation of erythrocyte differentiation2.49e-031.00e+008.646114
GO:0032269negative regulation of cellular protein metabolic process2.49e-031.00e+008.646114
GO:2000630positive regulation of miRNA metabolic process2.49e-031.00e+008.646114
GO:0030098lymphocyte differentiation2.49e-031.00e+008.646114
GO:0060684epithelial-mesenchymal cell signaling2.49e-031.00e+008.646114
GO:0051835positive regulation of synapse structural plasticity2.49e-031.00e+008.646114
GO:0048664neuron fate determination2.49e-031.00e+008.646114
GO:0072384organelle transport along microtubule2.49e-031.00e+008.646114
GO:0001714endodermal cell fate specification3.12e-031.00e+008.324115
GO:0035088establishment or maintenance of apical/basal cell polarity3.12e-031.00e+008.324115
GO:0021796cerebral cortex regionalization3.12e-031.00e+008.324115
GO:1990138neuron projection extension3.12e-031.00e+008.324115
GO:0051525NFAT protein binding3.12e-031.00e+008.324125
GO:0036336dendritic cell migration3.12e-031.00e+008.324115
GO:0010884positive regulation of lipid storage3.12e-031.00e+008.324115
GO:0031256leading edge membrane3.12e-031.00e+008.324115
GO:0045347negative regulation of MHC class II biosynthetic process3.12e-031.00e+008.324115
GO:0060033anatomical structure regression3.12e-031.00e+008.324115
GO:0060789hair follicle placode formation3.74e-031.00e+008.061126
GO:0007097nuclear migration3.74e-031.00e+008.061116
GO:0002320lymphoid progenitor cell differentiation3.74e-031.00e+008.061116
GO:0003334keratinocyte development3.74e-031.00e+008.061116
GO:1902262apoptotic process involved in patterning of blood vessels3.74e-031.00e+008.061116
GO:0048554positive regulation of metalloenzyme activity3.74e-031.00e+008.061116
GO:0043497regulation of protein heterodimerization activity3.74e-031.00e+008.061116
GO:0000122negative regulation of transcription from RNA polymerase II promoter4.31e-031.00e+003.076337570
GO:0071354cellular response to interleukin-64.36e-031.00e+007.839127
GO:0051988regulation of attachment of spindle microtubules to kinetochore4.36e-031.00e+007.839127
GO:0045814negative regulation of gene expression, epigenetic4.36e-031.00e+007.839127
GO:0051489regulation of filopodium assembly4.36e-031.00e+007.839117
GO:0005667transcription factor complex4.98e-031.00e+004.195217175
GO:0071316cellular response to nicotine4.98e-031.00e+007.646118
GO:0005515protein binding5.23e-031.00e+001.09081986024
GO:0008199ferric iron binding5.60e-031.00e+007.476119
GO:0010225response to UV-C5.60e-031.00e+007.476129
GO:0090136epithelial cell-cell adhesion5.60e-031.00e+007.476119
GO:0000975regulatory region DNA binding5.60e-031.00e+007.476129
GO:0000400four-way junction DNA binding5.60e-031.00e+007.476119
GO:0006826iron ion transport5.60e-031.00e+007.476119
GO:0030851granulocyte differentiation5.60e-031.00e+007.476119
GO:0021895cerebral cortex neuron differentiation5.60e-031.00e+007.476119
GO:0035413positive regulation of catenin import into nucleus6.22e-031.00e+007.3241210
GO:0031274positive regulation of pseudopodium assembly6.22e-031.00e+007.3241210
GO:0060047heart contraction6.22e-031.00e+007.3241110
GO:0060391positive regulation of SMAD protein import into nucleus6.85e-031.00e+007.1871411
GO:0035198miRNA binding7.47e-031.00e+007.0611112
GO:0051213dioxygenase activity8.09e-031.00e+006.9461113
GO:0042789mRNA transcription from RNA polymerase II promoter8.09e-031.00e+006.9461213
GO:0046688response to copper ion8.09e-031.00e+006.9461113
GO:0010744positive regulation of macrophage derived foam cell differentiation8.70e-031.00e+006.8391114
GO:0031293membrane protein intracellular domain proteolysis8.70e-031.00e+006.8391114
GO:0031333negative regulation of protein complex assembly8.70e-031.00e+006.8391114
GO:0031996thioesterase binding8.70e-031.00e+006.8391114
GO:0071375cellular response to peptide hormone stimulus8.70e-031.00e+006.8391214
GO:0043011myeloid dendritic cell differentiation9.32e-031.00e+006.7391215
GO:0001824blastocyst development9.32e-031.00e+006.7391215
GO:0051233spindle midzone9.32e-031.00e+006.7391215
GO:0048854brain morphogenesis9.32e-031.00e+006.7391215
GO:0008134transcription factor binding9.34e-031.00e+003.727218242
GO:0042176regulation of protein catabolic process9.94e-031.00e+006.6461216
GO:0051276chromosome organization9.94e-031.00e+006.6461216
GO:0048593camera-type eye morphogenesis9.94e-031.00e+006.6461116
GO:0030742GTP-dependent protein binding1.06e-021.00e+006.5591117
GO:0090316positive regulation of intracellular protein transport1.06e-021.00e+006.5591217
GO:0045944positive regulation of transcription from RNA polymerase II promoter1.07e-021.00e+002.607341789
GO:0006357regulation of transcription from RNA polymerase II promoter1.10e-021.00e+003.602223264
GO:0007088regulation of mitosis1.12e-021.00e+006.4761118
GO:0046847filopodium assembly1.18e-021.00e+006.3981119
GO:0006954inflammatory response1.21e-021.00e+003.53226277
GO:0055072iron ion homeostasis1.30e-021.00e+006.2541221
GO:0031435mitogen-activated protein kinase kinase kinase binding1.30e-021.00e+006.2541121
GO:0031424keratinization1.36e-021.00e+006.1871122
GO:0036464cytoplasmic ribonucleoprotein granule1.36e-021.00e+006.1871222
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription1.36e-021.00e+006.1871422
GO:1900026positive regulation of substrate adhesion-dependent cell spreading1.43e-021.00e+006.1231323
GO:0002040sprouting angiogenesis1.43e-021.00e+006.1231223
GO:0051017actin filament bundle assembly1.43e-021.00e+006.1231123
GO:0007163establishment or maintenance of cell polarity1.49e-021.00e+006.0611224
GO:0031519PcG protein complex1.55e-021.00e+006.0021125
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity1.61e-021.00e+005.9461326
GO:0045859regulation of protein kinase activity1.61e-021.00e+005.9461126
GO:0000976transcription regulatory region sequence-specific DNA binding1.61e-021.00e+005.9461326
GO:0051149positive regulation of muscle cell differentiation1.67e-021.00e+005.8911427
GO:0032467positive regulation of cytokinesis1.67e-021.00e+005.8911227
GO:0031069hair follicle morphogenesis1.67e-021.00e+005.8911127
GO:0072686mitotic spindle1.80e-021.00e+005.7881329
GO:0003723RNA binding1.81e-021.00e+003.228218342
GO:0043565sequence-specific DNA binding1.85e-021.00e+003.212211346
GO:0034644cellular response to UV1.86e-021.00e+005.7391130
GO:0031647regulation of protein stability1.86e-021.00e+005.7391430
GO:0071347cellular response to interleukin-11.92e-021.00e+005.6921231
GO:0031072heat shock protein binding2.04e-021.00e+005.6021233
GO:0001085RNA polymerase II transcription factor binding2.04e-021.00e+005.6021233
GO:0005925focal adhesion2.05e-021.00e+003.13029366
GO:0042692muscle cell differentiation2.10e-021.00e+005.5591434
GO:0034332adherens junction organization2.22e-021.00e+005.4761236
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway2.22e-021.00e+005.4761236
GO:0045740positive regulation of DNA replication2.22e-021.00e+005.4761136
GO:0030218erythrocyte differentiation2.29e-021.00e+005.4371137
GO:0006892post-Golgi vesicle-mediated transport2.65e-021.00e+005.2201243
GO:0021762substantia nigra development2.71e-021.00e+005.1871444
GO:0034613cellular protein localization2.71e-021.00e+005.1871244
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding2.71e-021.00e+005.1871444
GO:0043966histone H3 acetylation2.77e-021.00e+005.1541545
GO:0001047core promoter binding2.77e-021.00e+005.1541545
GO:0043525positive regulation of neuron apoptotic process2.83e-021.00e+005.1231446
GO:0090263positive regulation of canonical Wnt signaling pathway2.96e-021.00e+005.0611348
GO:0007030Golgi organization3.02e-021.00e+005.0311349
GO:0030175filopodium3.08e-021.00e+005.0021150
GO:0006879cellular iron ion homeostasis3.14e-021.00e+004.9741351
GO:0009611response to wounding3.20e-021.00e+004.9461552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.26e-021.00e+004.9181553
GO:0005634nucleus3.27e-021.00e+001.07761594559
GO:0045893positive regulation of transcription, DNA-templated3.38e-021.00e+002.745224478
GO:0046330positive regulation of JNK cascade3.38e-021.00e+004.8651255
GO:0000724double-strand break repair via homologous recombination3.38e-021.00e+004.8651255
GO:0003677DNA binding3.43e-021.00e+001.9813491218
GO:0050728negative regulation of inflammatory response3.44e-021.00e+004.8391356
GO:0042802identical protein binding3.46e-021.00e+002.727219484
GO:0033138positive regulation of peptidyl-serine phosphorylation3.62e-021.00e+004.7641259
GO:0032481positive regulation of type I interferon production3.74e-021.00e+004.7151661
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity3.74e-021.00e+004.7151461
GO:0030141secretory granule3.80e-021.00e+004.6921462
GO:0006310DNA recombination3.98e-021.00e+004.6241765
GO:0034146toll-like receptor 5 signaling pathway3.98e-021.00e+004.6241465
GO:0071260cellular response to mechanical stimulus3.98e-021.00e+004.6241465
GO:0031295T cell costimulation3.98e-021.00e+004.6241165
GO:0034166toll-like receptor 10 signaling pathway3.98e-021.00e+004.6241465
GO:0035264multicellular organism growth4.11e-021.00e+004.5801267
GO:0010468regulation of gene expression4.17e-021.00e+004.5591268
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway4.35e-021.00e+004.4961471
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway4.35e-021.00e+004.4961471
GO:0034162toll-like receptor 9 signaling pathway4.41e-021.00e+004.4761472
GO:0009791post-embryonic development4.47e-021.00e+004.4561373
GO:0034134toll-like receptor 2 signaling pathway4.47e-021.00e+004.4561473
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.53e-021.00e+004.4371274
GO:0002020protease binding4.53e-021.00e+004.4371674
GO:0060070canonical Wnt signaling pathway4.59e-021.00e+004.4171475
GO:0035666TRIF-dependent toll-like receptor signaling pathway4.64e-021.00e+004.3981376
GO:0010629negative regulation of gene expression4.70e-021.00e+004.3791477
GO:0002756MyD88-independent toll-like receptor signaling pathway4.76e-021.00e+004.3611378
GO:0034138toll-like receptor 3 signaling pathway4.82e-021.00e+004.3421379
GO:0002755MyD88-dependent toll-like receptor signaling pathway4.88e-021.00e+004.3241580
GO:0045177apical part of cell4.94e-021.00e+004.3061381
GO:0071222cellular response to lipopolysaccharide4.94e-021.00e+004.3061481
GO:0009653anatomical structure morphogenesis5.06e-021.00e+004.2711283
GO:0045087innate immune response5.06e-021.00e+002.427215596
GO:0009952anterior/posterior pattern specification5.06e-021.00e+004.2711483
GO:0050852T cell receptor signaling pathway5.18e-021.00e+004.2371285
GO:0003690double-stranded DNA binding5.24e-021.00e+004.2201386
GO:0006979response to oxidative stress5.30e-021.00e+004.2031687
GO:0005829cytosol5.42e-021.00e+001.3614862496
GO:0016363nuclear matrix5.54e-021.00e+004.1381691
GO:0034142toll-like receptor 4 signaling pathway5.83e-021.00e+004.0611496
GO:0016568chromatin modification5.95e-021.00e+004.0311498
GO:0005506iron ion binding6.37e-021.00e+003.93213105
GO:0030496midbody6.54e-021.00e+003.89112108
GO:0002224toll-like receptor signaling pathway6.60e-021.00e+003.87814109
GO:0005815microtubule organizing center6.60e-021.00e+003.87813109
GO:0051056regulation of small GTPase mediated signal transduction6.95e-021.00e+003.80113115
GO:0030036actin cytoskeleton organization7.42e-021.00e+003.70413123
GO:0051092positive regulation of NF-kappaB transcription factor activity7.48e-021.00e+003.69215124
GO:0000790nuclear chromatin7.77e-021.00e+003.63516129
GO:0005911cell-cell junction8.18e-021.00e+003.55912136
GO:0061024membrane organization8.69e-021.00e+003.46614145
GO:0010628positive regulation of gene expression8.75e-021.00e+003.45617146
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription8.81e-021.00e+003.44616147
GO:0006974cellular response to DNA damage stimulus9.04e-021.00e+003.40817151
GO:0043005neuron projection9.38e-021.00e+003.35213157
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9.84e-021.00e+003.280112165
GO:0038095Fc-epsilon receptor signaling pathway1.00e-011.00e+003.25415168
GO:0031625ubiquitin protein ligase binding1.06e-011.00e+003.17015178
GO:0003714transcription corepressor activity1.06e-011.00e+003.170111178
GO:0007173epidermal growth factor receptor signaling pathway1.12e-011.00e+003.08415189
GO:0003924GTPase activity1.16e-011.00e+003.02417197
GO:0001701in utero embryonic development1.19e-011.00e+002.99518201
GO:0008270zinc ion binding1.24e-011.00e+001.685227997
GO:0006184GTP catabolic process1.26e-011.00e+002.90517214
GO:0003713transcription coactivator activity1.39e-011.00e+002.757124237
GO:0005654nucleoplasm1.42e-011.00e+001.5672641082
GO:0043025neuronal cell body1.43e-011.00e+002.71019245
GO:0007283spermatogenesis1.52e-011.00e+002.61313262
GO:0006281DNA repair1.52e-011.00e+002.618114261
GO:0048011neurotrophin TRK receptor signaling pathway1.56e-011.00e+002.57517269
GO:0007264small GTPase mediated signal transduction1.61e-011.00e+002.52213279
GO:0042493response to drug1.64e-011.00e+002.49616284
GO:0030154cell differentiation1.73e-011.00e+002.41315301
GO:0005525GTP binding1.78e-011.00e+002.370112310
GO:0019901protein kinase binding1.81e-011.00e+002.338118317
GO:0007411axon guidance1.82e-011.00e+002.32915319
GO:0005737cytoplasm1.87e-011.00e+000.76741243767
GO:0030054cell junction1.91e-011.00e+002.25415336
GO:0000139Golgi membrane2.04e-011.00e+002.15017361
GO:0006351transcription, DNA-templated2.26e-011.00e+001.1482571446
GO:0045892negative regulation of transcription, DNA-templated2.30e-011.00e+001.956124413
GO:0055114oxidation-reduction process2.34e-011.00e+001.932110420
GO:0043066negative regulation of apoptotic process2.36e-011.00e+001.918116424
GO:0055085transmembrane transport2.41e-011.00e+001.88118435
GO:0007596blood coagulation2.51e-011.00e+001.816111455
GO:0005730nucleolus2.73e-011.00e+000.9662661641
GO:0016020membrane2.83e-011.00e+000.9312461681
GO:0006915apoptotic process2.98e-011.00e+001.530112555
GO:0042803protein homodimerization activity3.16e-011.00e+001.429119595
GO:0070062extracellular vesicular exosome4.56e-011.00e+000.4172572400
GO:0005739mitochondrion4.76e-011.00e+000.683123998
GO:0044822poly(A) RNA binding4.96e-011.00e+000.6021501056
GO:0005886plasma membrane8.31e-011.00e+00-0.6881492582