int-snw-6299

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.869 7.06e-16 3.19e-04 2.52e-03
chia-screen-data-Fav-int-snw-6299 subnetwork

Genes (15)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
HCFC1 3054 40-2.9253.44971YesYes
[ SALL1 ] 6299 1-1.2852.8699--
ZFP36 7538 10-2.9682.86924YesYes
PHB 5245 15-2.7433.004127YesYes
HDAC1 3065 2-1.7122.869566--
YAP1 10413 94-4.2563.53853Yes-
BCL6B 255877 2-2.7232.8693YesYes
SRSF3 6428 73-2.9923.53854Yes-
NFRKB 4798 48-3.1293.10823YesYes
POU5F1 5460 133-5.1483.538179YesYes
HNRNPU 3192 76-2.8693.538139Yes-
CDX2 1045 3-2.0372.95533YesYes
SON 6651 9-3.8443.1089YesYes
CDK12 51755 6-2.7142.94415Yes-
SUMO1 7341 7-1.6963.050439--

Interactions (19)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
NFRKB 4798 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
HDAC1 3065 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
SUMO1 7341 CDK12 51755 pp -- int.I2D: BioGrid
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
CDX2 1045 SALL1 6299 pp -- int.I2D: I2D-c_Mouse
HCFC1 3054 HDAC1 3065 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BCI, BioGrid, IntAct;
int.Ravasi: -
HCFC1 3054 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU 3192 SUMO1 7341 pp -- int.I2D: BioGrid
HDAC1 3065 PHB 5245 pp -- int.I2D: BioGrid, BCI, HPRD;
int.HPRD: in vivo
SALL1 6299 SUMO1 7341 pp -- int.I2D: BioGrid, BIND
SON 6651 SUMO1 7341 pp -- int.I2D: BioGrid
HDAC1 3065 ZFP36 7538 pp -- int.I2D: BioGrid
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
POU5F1 5460 SUMO1 7341 pp -- int.I2D: BioGrid, BioGrid_Mouse
HDAC1 3065 SALL1 6299 pp -- int.I2D: HPRD;
int.Ravasi: -;
int.HPRD: in vivo
CDX2 1045 HDAC1 3065 pp -- int.I2D: I2D-c_Mouse
POU5F1 5460 SALL1 6299 pp -- int.I2D: IntAct_Mouse
HDAC1 3065 BCL6B 255877 pp -- int.I2D: BioGrid

Related GO terms (261)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000122negative regulation of transcription from RNA polymerase II promoter7.08e-071.02e-023.562737570
GO:0005634nucleus1.04e-061.50e-021.562141594559
GO:0016575histone deacetylation1.20e-061.73e-027.1023321
GO:0005654nucleoplasm3.91e-065.63e-022.8308641082
GO:0044212transcription regulatory region DNA binding2.19e-053.16e-014.517417168
GO:0016607nuclear speck2.41e-053.47e-014.483412172
GO:0006366transcription from RNA polymerase II promoter4.77e-056.88e-013.520530419
GO:0008380RNA splicing7.24e-051.00e+004.076422228
GO:0060766negative regulation of androgen receptor signaling pathway7.82e-051.00e+007.2092313
GO:0003677DNA binding1.06e-041.00e+002.4667491218
GO:0016581NuRD complex1.20e-041.00e+006.9092216
GO:0004407histone deacetylase activity1.20e-041.00e+006.9092216
GO:0044822poly(A) RNA binding4.27e-041.00e+002.4506501056
GO:0010467gene expression4.31e-041.00e+002.845545669
GO:0005515protein binding4.61e-041.00e+001.053131986024
GO:0003700sequence-specific DNA binding transcription factor activity5.27e-041.00e+002.782539699
GO:0005730nucleolus6.85e-041.00e+002.0367661641
GO:0045892negative regulation of transcription, DNA-templated7.04e-041.00e+003.219424413
GO:0035019somatic stem cell maintenance7.70e-041.00e+005.5872640
GO:0090308regulation of methylation-dependent chromatin silencing1.04e-031.00e+009.909111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway1.04e-031.00e+009.909111
GO:0060965negative regulation of gene silencing by miRNA1.04e-031.00e+009.909111
GO:0060795cell fate commitment involved in formation of primary germ layer1.04e-031.00e+009.909111
GO:0031129inductive cell-cell signaling1.04e-031.00e+009.909111
GO:0072073kidney epithelium development1.04e-031.00e+009.909111
GO:0042733embryonic digit morphogenesis1.06e-031.00e+005.3552247
GO:0045893positive regulation of transcription, DNA-templated1.22e-031.00e+003.008424478
GO:0008134transcription factor binding1.83e-031.00e+003.575318242
GO:0060242contact inhibition2.08e-031.00e+008.909112
GO:0019046release from viral latency2.08e-031.00e+008.909122
GO:0070816phosphorylation of RNA polymerase II C-terminal domain2.08e-031.00e+008.909112
GO:0090204protein localization to nuclear pore2.08e-031.00e+008.909112
GO:0009786regulation of asymmetric cell division2.08e-031.00e+008.909112
GO:0061034olfactory bulb mitral cell layer development2.08e-031.00e+008.909112
GO:0072092ureteric bud invasion2.08e-031.00e+008.909112
GO:0002944cyclin K-CDK12 complex2.08e-031.00e+008.909112
GO:0042826histone deacetylase binding2.47e-031.00e+004.7392472
GO:0006355regulation of transcription, DNA-templated2.61e-031.00e+002.270543997
GO:0060913cardiac cell fate determination3.12e-031.00e+008.324113
GO:0001650fibrillar center3.12e-031.00e+008.324113
GO:0050779RNA destabilization3.12e-031.00e+008.324113
GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex3.12e-031.00e+008.324113
GO:0061198fungiform papilla formation3.12e-031.00e+008.324113
GO:0003130BMP signaling pathway involved in heart induction3.12e-031.00e+008.324113
GO:0021553olfactory nerve development3.12e-031.00e+008.324113
GO:0001649osteoblast differentiation4.00e-031.00e+004.3862592
GO:0032680regulation of tumor necrosis factor production4.15e-031.00e+007.909114
GO:0030578PML body organization4.15e-031.00e+007.909114
GO:0021889olfactory bulb interneuron differentiation4.15e-031.00e+007.909114
GO:0051726regulation of cell cycle4.44e-031.00e+004.3092597
GO:0003723RNA binding4.86e-031.00e+003.076318342
GO:0070461SAGA-type complex5.19e-031.00e+007.587125
GO:0001714endodermal cell fate specification5.19e-031.00e+007.587115
GO:0019957C-C chemokine binding5.19e-031.00e+007.587115
GO:0070934CRD-mediated mRNA stabilization5.19e-031.00e+007.587125
GO:0035925mRNA 3'-UTR AU-rich region binding5.19e-031.00e+007.587115
GO:0043405regulation of MAP kinase activity5.19e-031.00e+007.587115
GO:0005737cytoplasm5.73e-031.00e+001.20091243767
GO:0050847progesterone receptor signaling pathway6.22e-031.00e+007.324126
GO:0050733RS domain binding6.22e-031.00e+007.324116
GO:2000323negative regulation of glucocorticoid receptor signaling pathway6.22e-031.00e+007.324116
GO:0070937CRD-mediated mRNA stability complex6.22e-031.00e+007.324136
GO:0060789hair follicle placode formation6.22e-031.00e+007.324126
GO:0019213deacetylase activity6.22e-031.00e+007.324116
GO:0071354cellular response to interleukin-67.26e-031.00e+007.102127
GO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesis7.26e-031.00e+007.102117
GO:0010870positive regulation of receptor biosynthetic process7.26e-031.00e+007.102117
GO:2000177regulation of neural precursor cell proliferation7.26e-031.00e+007.102117
GO:0045944positive regulation of transcription from RNA polymerase II promoter7.47e-031.00e+002.285441789
GO:0009913epidermal cell differentiation8.29e-031.00e+006.909118
GO:0070688MLL5-L complex8.29e-031.00e+006.909118
GO:0035137hindlimb morphogenesis8.29e-031.00e+006.909118
GO:0043254regulation of protein complex assembly8.29e-031.00e+006.909118
GO:0042473outer ear morphogenesis8.29e-031.00e+006.909118
GO:0043996histone acetyltransferase activity (H4-K8 specific)9.32e-031.00e+006.739159
GO:0010832negative regulation of myotube differentiation9.32e-031.00e+006.739119
GO:0043995histone acetyltransferase activity (H4-K5 specific)9.32e-031.00e+006.739159
GO:0006476protein deacetylation9.32e-031.00e+006.739119
GO:0046972histone acetyltransferase activity (H4-K16 specific)9.32e-031.00e+006.739159
GO:0035278negative regulation of translation involved in gene silencing by miRNA9.32e-031.00e+006.739119
GO:0048188Set1C/COMPASS complex9.32e-031.00e+006.739149
GO:0035136forelimb morphogenesis9.32e-031.00e+006.739119
GO:0010944negative regulation of transcription by competitive promoter binding9.32e-031.00e+006.739119
GO:0060711labyrinthine layer development9.32e-031.00e+006.739139
GO:0033558protein deacetylase activity9.32e-031.00e+006.739119
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay1.04e-021.00e+006.5871210
GO:0035413positive regulation of catenin import into nucleus1.04e-021.00e+006.5871210
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity1.04e-021.00e+006.5871110
GO:0061029eyelid development in camera-type eye1.04e-021.00e+006.5871210
GO:0010369chromocenter1.14e-021.00e+006.4501111
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening1.14e-021.00e+006.4501211
GO:0019789SUMO ligase activity1.14e-021.00e+006.4501111
GO:0060391positive regulation of SMAD protein import into nucleus1.14e-021.00e+006.4501411
GO:0006397mRNA processing1.17e-021.00e+003.587210160
GO:0000398mRNA splicing, via spliceosome1.22e-021.00e+003.552215164
GO:0046970NAD-dependent histone deacetylase activity (H4-K16 specific)1.24e-021.00e+006.3241112
GO:0006402mRNA catabolic process1.24e-021.00e+006.3241112
GO:00709353'-UTR-mediated mRNA stabilization1.24e-021.00e+006.3241312
GO:0016580Sin3 complex1.24e-021.00e+006.3241112
GO:0043922negative regulation by host of viral transcription1.24e-021.00e+006.3241112
GO:0097372NAD-dependent histone deacetylase activity (H3-K18 specific)1.24e-021.00e+006.3241112
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)1.24e-021.00e+006.3241112
GO:0035198miRNA binding1.24e-021.00e+006.3241112
GO:0071480cellular response to gamma radiation1.34e-021.00e+006.2091113
GO:0061647histone H3-K9 modification1.34e-021.00e+006.2091113
GO:0042789mRNA transcription from RNA polymerase II promoter1.34e-021.00e+006.2091213
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)1.34e-021.00e+006.2091113
GO:0031334positive regulation of protein complex assembly1.34e-021.00e+006.2091213
GO:0031625ubiquitin protein ligase binding1.43e-021.00e+003.43325178
GO:0003714transcription corepressor activity1.43e-021.00e+003.433211178
GO:0003281ventricular septum development1.45e-021.00e+006.1021114
GO:0031011Ino80 complex1.45e-021.00e+006.1021614
GO:0048566embryonic digestive tract development1.45e-021.00e+006.1021114
GO:0017091AU-rich element binding1.45e-021.00e+006.1021214
GO:0006367transcription initiation from RNA polymerase II promoter1.52e-021.00e+003.386222184
GO:0043981histone H4-K5 acetylation1.55e-021.00e+006.0021515
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.55e-021.00e+006.0021315
GO:0001824blastocyst development1.55e-021.00e+006.0021215
GO:0043982histone H4-K8 acetylation1.55e-021.00e+006.0021515
GO:0008353RNA polymerase II carboxy-terminal domain kinase activity1.65e-021.00e+005.9091116
GO:0060173limb development1.65e-021.00e+005.9091116
GO:0043274phospholipase binding1.65e-021.00e+005.9091116
GO:0060334regulation of interferon-gamma-mediated signaling pathway1.65e-021.00e+005.9091116
GO:0045638negative regulation of myeloid cell differentiation1.65e-021.00e+005.9091116
GO:0001829trophectodermal cell differentiation1.75e-021.00e+005.8221217
GO:0070933histone H4 deacetylation1.75e-021.00e+005.8221117
GO:0030332cyclin binding1.86e-021.00e+005.7391118
GO:007188914-3-3 protein binding1.86e-021.00e+005.7391218
GO:0033613activating transcription factor binding1.86e-021.00e+005.7391318
GO:0043984histone H4-K16 acetylation1.96e-021.00e+005.6611519
GO:0001106RNA polymerase II transcription corepressor activity2.16e-021.00e+005.5171221
GO:0030325adrenal gland development2.16e-021.00e+005.5171121
GO:0000123histone acetyltransferase complex2.16e-021.00e+005.5171621
GO:0070932histone H3 deacetylation2.16e-021.00e+005.5171221
GO:0043484regulation of RNA splicing2.26e-021.00e+005.4501122
GO:0000792heterochromatin2.26e-021.00e+005.4501122
GO:0045787positive regulation of cell cycle2.26e-021.00e+005.4501222
GO:0045879negative regulation of smoothened signaling pathway2.26e-021.00e+005.4501122
GO:0036464cytoplasmic ribonucleoprotein granule2.26e-021.00e+005.4501222
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription2.26e-021.00e+005.4501422
GO:0043044ATP-dependent chromatin remodeling2.37e-021.00e+005.3861223
GO:0003713transcription coactivator activity2.45e-021.00e+003.020224237
GO:0000794condensed nuclear chromosome2.47e-021.00e+005.3241124
GO:0016925protein sumoylation2.57e-021.00e+005.2651225
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening2.57e-021.00e+005.2651325
GO:0008406gonad development2.57e-021.00e+005.2651125
GO:0035329hippo signaling2.67e-021.00e+005.2091526
GO:0000976transcription regulatory region sequence-specific DNA binding2.67e-021.00e+005.2091326
GO:0043392negative regulation of DNA binding2.67e-021.00e+005.2091426
GO:0030177positive regulation of Wnt signaling pathway2.77e-021.00e+005.1541127
GO:0001103RNA polymerase II repressing transcription factor binding2.77e-021.00e+005.1541227
GO:0021983pituitary gland development2.77e-021.00e+005.1541227
GO:0045597positive regulation of cell differentiation2.77e-021.00e+005.1541127
GO:0071339MLL1 complex2.77e-021.00e+005.1541627
GO:0031492nucleosomal DNA binding2.77e-021.00e+005.1541227
GO:0003727single-stranded RNA binding2.87e-021.00e+005.1021228
GO:0070491repressing transcription factor binding2.87e-021.00e+005.1021228
GO:0000118histone deacetylase complex2.87e-021.00e+005.1021128
GO:0071897DNA biosynthetic process2.87e-021.00e+005.1021128
GO:0006281DNA repair2.93e-021.00e+002.881214261
GO:0008333endosome to lysosome transport2.98e-021.00e+005.0511229
GO:0010494cytoplasmic stress granule3.08e-021.00e+005.0021230
GO:0004693cyclin-dependent protein serine/threonine kinase activity3.18e-021.00e+004.9551131
GO:0042594response to starvation3.18e-021.00e+004.9551431
GO:0019899enzyme binding3.27e-021.00e+002.79529277
GO:1903507negative regulation of nucleic acid-templated transcription3.28e-021.00e+004.9091232
GO:0001568blood vessel development3.58e-021.00e+004.7801235
GO:0032880regulation of protein localization3.78e-021.00e+004.7001237
GO:0001657ureteric bud development3.88e-021.00e+004.6611238
GO:0045786negative regulation of cell cycle3.98e-021.00e+004.6241339
GO:0031124mRNA 3'-end processing4.28e-021.00e+004.5171242
GO:0001658branching involved in ureteric bud morphogenesis4.38e-021.00e+004.4831343
GO:0003682chromatin binding4.43e-021.00e+002.556219327
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process4.48e-021.00e+004.4501344
GO:0001047core promoter binding4.58e-021.00e+004.4171545
GO:0006369termination of RNA polymerase II transcription4.58e-021.00e+004.4171245
GO:0043565sequence-specific DNA binding4.90e-021.00e+002.475211346
GO:0032922circadian regulation of gene expression4.98e-021.00e+004.2941149
GO:0000910cytokinesis5.18e-021.00e+004.2371251
GO:0017053transcriptional repressor complex5.18e-021.00e+004.2371251
GO:0000226microtubule cytoskeleton organization5.28e-021.00e+004.2091252
GO:0009611response to wounding5.28e-021.00e+004.2091552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding5.38e-021.00e+004.1811553
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay5.38e-021.00e+004.1811453
GO:0042475odontogenesis of dentin-containing tooth5.57e-021.00e+004.1281155
GO:0050728negative regulation of inflammatory response5.67e-021.00e+004.1021356
GO:0005643nuclear pore5.77e-021.00e+004.07611157
GO:0008284positive regulation of cell proliferation5.85e-021.00e+002.332210382
GO:0006396RNA processing5.97e-021.00e+004.0271559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity5.97e-021.00e+004.0271659
GO:0008013beta-catenin binding6.06e-021.00e+004.0021960
GO:0006406mRNA export from nucleus6.16e-021.00e+003.9781461
GO:0060333interferon-gamma-mediated signaling pathway6.26e-021.00e+003.9551362
GO:0045666positive regulation of neuron differentiation6.36e-021.00e+003.9321363
GO:0006310DNA recombination6.55e-021.00e+003.8871765
GO:0006338chromatin remodeling6.65e-021.00e+003.8651366
GO:0010468regulation of gene expression6.85e-021.00e+003.8221268
GO:0043066negative regulation of apoptotic process7.03e-021.00e+002.181216424
GO:0060021palate development7.24e-021.00e+003.7391172
GO:0003729mRNA binding7.24e-021.00e+003.7391472
GO:0000785chromatin7.33e-021.00e+003.7191673
GO:0002020protease binding7.43e-021.00e+003.7001674
GO:0001843neural tube closure7.43e-021.00e+003.7001274
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity7.43e-021.00e+003.7001474
GO:0001822kidney development7.82e-021.00e+003.6241378
GO:0071013catalytic step 2 spliceosome7.82e-021.00e+003.6241778
GO:0009653anatomical structure morphogenesis8.30e-021.00e+003.5341283
GO:0009952anterior/posterior pattern specification8.30e-021.00e+003.5341483
GO:0009887organ morphogenesis8.58e-021.00e+003.4831586
GO:0003690double-stranded DNA binding8.58e-021.00e+003.4831386
GO:0050821protein stabilization8.78e-021.00e+003.4501388
GO:0016605PML body8.78e-021.00e+003.4501388
GO:0016568chromatin modification9.73e-021.00e+003.2941498
GO:0003676nucleic acid binding1.06e-011.00e+003.16812107
GO:0030308negative regulation of cell growth1.09e-011.00e+003.12816110
GO:0030529ribonucleoprotein complex1.10e-011.00e+003.10215112
GO:0006325chromatin organization1.16e-011.00e+003.027112118
GO:0007219Notch signaling pathway1.18e-011.00e+003.00215120
GO:0007179transforming growth factor beta receptor signaling pathway1.25e-011.00e+002.909111128
GO:0000790nuclear chromatin1.26e-011.00e+002.89816129
GO:0045202synapse1.33e-011.00e+002.82215136
GO:0007507heart development1.35e-011.00e+002.79017139
GO:0010628positive regulation of gene expression1.42e-011.00e+002.71917146
GO:0042981regulation of apoptotic process1.45e-011.00e+002.68014150
GO:0006974cellular response to DNA damage stimulus1.46e-011.00e+002.67117151
GO:0046872metal ion binding1.49e-011.00e+001.1423291307
GO:0046777protein autophosphorylation1.52e-011.00e+002.60514158
GO:0043687post-translational protein modification1.56e-011.00e+002.56915162
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.59e-011.00e+002.543112165
GO:0031965nuclear membrane1.61e-011.00e+002.517110168
GO:0005667transcription factor complex1.67e-011.00e+002.458117175
GO:0007049cell cycle1.67e-011.00e+002.46616174
GO:0004672protein kinase activity1.69e-011.00e+002.44213177
GO:0019221cytokine-mediated signaling pathway2.07e-011.00e+002.12118221
GO:0016071mRNA metabolic process2.09e-011.00e+002.10818223
GO:0030425dendrite2.14e-011.00e+002.06416230
GO:0043025neuronal cell body2.27e-011.00e+001.97319245
GO:0016070RNA metabolic process2.28e-011.00e+001.96118247
GO:0000166nucleotide binding2.38e-011.00e+001.892113259
GO:0048011neurotrophin TRK receptor signaling pathway2.46e-011.00e+001.83817269
GO:0016020membrane2.51e-011.00e+000.7793461681
GO:0005743mitochondrial inner membrane2.53e-011.00e+001.79516277
GO:0006954inflammatory response2.53e-011.00e+001.79516277
GO:0005829cytosol2.54e-011.00e+000.6244862496
GO:0043234protein complex2.67e-011.00e+001.705111295
GO:0035556intracellular signal transduction2.73e-011.00e+001.66619303
GO:0005739mitochondrion2.79e-011.00e+000.946223998
GO:0019901protein kinase binding2.84e-011.00e+001.601118317
GO:0008283cell proliferation2.92e-011.00e+001.552114328
GO:0008285negative regulation of cell proliferation3.11e-011.00e+001.446110353
GO:0000278mitotic cell cycle3.38e-011.00e+001.298115391
GO:0009986cell surface3.46e-011.00e+001.25819402
GO:0007596blood coagulation3.82e-011.00e+001.079111455
GO:0044267cellular protein metabolic process3.94e-011.00e+001.020120474
GO:0005524ATP binding3.97e-011.00e+000.5672311298
GO:0042802identical protein binding4.01e-011.00e+000.990119484
GO:0016032viral process4.32e-011.00e+000.848126534
GO:0006351transcription, DNA-templated4.52e-011.00e+000.4112571446
GO:0005887integral component of plasma membrane6.15e-011.00e+000.115110888
GO:0007165signal transduction6.23e-011.00e+000.084113907
GO:0070062extracellular vesicular exosome9.35e-011.00e+00-1.3201572400