Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
chia-screen-data-Fav | 2.856 | 9.97e-16 | 3.78e-04 | 2.84e-03 |
Gene Symbol | Entrez Gene ID | Frequency | chia-screen-data-Fav gene score | Best subnetwork score | Degree | Chia-Hits Primary | Chia-Hits Secondary |
---|---|---|---|---|---|---|---|
HCFC1 | 3054 | 40 | -2.925 | 3.449 | 71 | Yes | Yes |
[ GATAD2B ] | 57459 | 1 | -1.233 | 2.856 | 27 | - | - |
ZFP36 | 7538 | 10 | -2.968 | 2.869 | 24 | Yes | Yes |
PHB | 5245 | 15 | -2.743 | 3.004 | 127 | Yes | Yes |
YAP1 | 10413 | 94 | -4.256 | 3.538 | 53 | Yes | - |
HDAC1 | 3065 | 2 | -1.712 | 2.869 | 566 | - | - |
HIST2H2BE | 8349 | 1 | -1.600 | 2.856 | 98 | - | - |
BCL6B | 255877 | 2 | -2.723 | 2.869 | 3 | Yes | Yes |
SRSF3 | 6428 | 73 | -2.992 | 3.538 | 54 | Yes | - |
NFRKB | 4798 | 48 | -3.129 | 3.108 | 23 | Yes | Yes |
POU5F1 | 5460 | 133 | -5.148 | 3.538 | 179 | Yes | Yes |
HNRNPU | 3192 | 76 | -2.869 | 3.538 | 139 | Yes | - |
DDIT3 | 1649 | 60 | -2.825 | 3.504 | 343 | Yes | Yes |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
POU5F1 | 5460 | GATAD2B | 57459 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse, WangEScmplx |
HCFC1 | 3054 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
HNRNPU | 3192 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
HDAC1 | 3065 | BCL6B | 255877 | pp | -- | int.I2D: BioGrid |
NFRKB | 4798 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
HCFC1 | 3054 | HDAC1 | 3065 | pp | -- | int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BCI, BioGrid, IntAct; int.Ravasi: - |
HDAC1 | 3065 | PHB | 5245 | pp | -- | int.I2D: BioGrid, BCI, HPRD; int.HPRD: in vivo |
HIST2H2BE | 8349 | GATAD2B | 57459 | pp | -- | int.I2D: BioGrid |
HDAC1 | 3065 | ZFP36 | 7538 | pp | -- | int.I2D: BioGrid |
DDIT3 | 1649 | HIST2H2BE | 8349 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
HDAC1 | 3065 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
DDIT3 | 1649 | HNRNPU | 3192 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
HDAC1 | 3065 | GATAD2B | 57459 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid |
POU5F1 | 5460 | SRSF3 | 6428 | pp | -- | int.I2D: BioGrid |
HNRNPU | 3192 | YAP1 | 10413 | pp | -- | int.I2D: HPRD; int.HPRD: in vitro, in vivo |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0005654 | nucleoplasm | 3.95e-08 | 5.70e-04 | 3.206 | 9 | 64 | 1082 |
GO:0044212 | transcription regulatory region DNA binding | 2.41e-07 | 3.48e-03 | 5.045 | 5 | 17 | 168 |
GO:0006355 | regulation of transcription, DNA-templated | 8.76e-06 | 1.26e-01 | 2.962 | 7 | 43 | 997 |
GO:0005634 | nucleus | 9.08e-06 | 1.31e-01 | 1.546 | 12 | 159 | 4559 |
GO:0003677 | DNA binding | 3.28e-05 | 4.73e-01 | 2.673 | 7 | 49 | 1218 |
GO:0060766 | negative regulation of androgen receptor signaling pathway | 5.82e-05 | 8.39e-01 | 7.415 | 2 | 3 | 13 |
GO:0042789 | mRNA transcription from RNA polymerase II promoter | 5.82e-05 | 8.39e-01 | 7.415 | 2 | 2 | 13 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 9.36e-05 | 1.00e+00 | 3.283 | 5 | 37 | 570 |
GO:0016575 | histone deacetylation | 1.56e-04 | 1.00e+00 | 6.723 | 2 | 3 | 21 |
GO:0043044 | ATP-dependent chromatin remodeling | 1.88e-04 | 1.00e+00 | 6.592 | 2 | 2 | 23 |
GO:0010467 | gene expression | 1.99e-04 | 1.00e+00 | 3.052 | 5 | 45 | 669 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 2.45e-04 | 1.00e+00 | 2.988 | 5 | 39 | 699 |
GO:0031492 | nucleosomal DNA binding | 2.60e-04 | 1.00e+00 | 6.361 | 2 | 2 | 27 |
GO:0042594 | response to starvation | 3.44e-04 | 1.00e+00 | 6.161 | 2 | 4 | 31 |
GO:0006366 | transcription from RNA polymerase II promoter | 4.08e-04 | 1.00e+00 | 3.405 | 4 | 30 | 419 |
GO:0060795 | cell fate commitment involved in formation of primary germ layer | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:2000016 | negative regulation of determination of dorsal identity | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0090308 | regulation of methylation-dependent chromatin silencing | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0090081 | regulation of heart induction by regulation of canonical Wnt signaling pathway | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0060965 | negative regulation of gene silencing by miRNA | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 1.01e-03 | 1.00e+00 | 5.388 | 2 | 5 | 53 |
GO:0008134 | transcription factor binding | 1.18e-03 | 1.00e+00 | 3.782 | 3 | 18 | 242 |
GO:0060242 | contact inhibition | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:0019046 | release from viral latency | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 2 | 2 |
GO:0009786 | regulation of asymmetric cell division | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:0044324 | regulation of transcription involved in anterior/posterior axis specification | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 |
GO:0042826 | histone deacetylase binding | 1.85e-03 | 1.00e+00 | 4.946 | 2 | 4 | 72 |
GO:0061198 | fungiform papilla formation | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 |
GO:0060913 | cardiac cell fate determination | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 |
GO:0003130 | BMP signaling pathway involved in heart induction | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 |
GO:0050779 | RNA destabilization | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 |
GO:0001649 | osteoblast differentiation | 3.00e-03 | 1.00e+00 | 4.592 | 2 | 5 | 92 |
GO:0032680 | regulation of tumor necrosis factor production | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 4.27e-03 | 1.00e+00 | 2.492 | 4 | 41 | 789 |
GO:0070461 | SAGA-type complex | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 2 | 5 |
GO:0001714 | endodermal cell fate specification | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 |
GO:0019957 | C-C chemokine binding | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 |
GO:0043620 | regulation of DNA-templated transcription in response to stress | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 |
GO:0070934 | CRD-mediated mRNA stabilization | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 2 | 5 |
GO:0035925 | mRNA 3'-UTR AU-rich region binding | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 |
GO:0006325 | chromatin organization | 4.88e-03 | 1.00e+00 | 4.233 | 2 | 12 | 118 |
GO:0045892 | negative regulation of transcription, DNA-templated | 5.38e-03 | 1.00e+00 | 3.011 | 3 | 24 | 413 |
GO:0060789 | hair follicle placode formation | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 2 | 6 |
GO:0050847 | progesterone receptor signaling pathway | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 2 | 6 |
GO:0019213 | deacetylase activity | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 1 | 6 |
GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 1 | 6 |
GO:0070937 | CRD-mediated mRNA stability complex | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 3 | 6 |
GO:0000790 | nuclear chromatin | 5.80e-03 | 1.00e+00 | 4.104 | 2 | 6 | 129 |
GO:0071354 | cellular response to interleukin-6 | 6.29e-03 | 1.00e+00 | 7.308 | 1 | 2 | 7 |
GO:0010870 | positive regulation of receptor biosynthetic process | 6.29e-03 | 1.00e+00 | 7.308 | 1 | 1 | 7 |
GO:0009913 | epidermal cell differentiation | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 1 | 8 |
GO:0001955 | blood vessel maturation | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 1 | 8 |
GO:0070688 | MLL5-L complex | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 1 | 8 |
GO:0043254 | regulation of protein complex assembly | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 1 | 8 |
GO:0006974 | cellular response to DNA damage stimulus | 7.87e-03 | 1.00e+00 | 3.877 | 2 | 7 | 151 |
GO:0045893 | positive regulation of transcription, DNA-templated | 8.07e-03 | 1.00e+00 | 2.800 | 3 | 24 | 478 |
GO:0010832 | negative regulation of myotube differentiation | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0043995 | histone acetyltransferase activity (H4-K5 specific) | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 5 | 9 |
GO:0006476 | protein deacetylation | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0046972 | histone acetyltransferase activity (H4-K16 specific) | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 5 | 9 |
GO:0035278 | negative regulation of translation involved in gene silencing by miRNA | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0048188 | Set1C/COMPASS complex | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 4 | 9 |
GO:0006983 | ER overload response | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0010944 | negative regulation of transcription by competitive promoter binding | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0043996 | histone acetyltransferase activity (H4-K8 specific) | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 5 | 9 |
GO:0033558 | protein deacetylase activity | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 9 |
GO:0035413 | positive regulation of catenin import into nucleus | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 2 | 10 |
GO:0061029 | eyelid development in camera-type eye | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 2 | 10 |
GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 2 | 10 |
GO:0000398 | mRNA splicing, via spliceosome | 9.23e-03 | 1.00e+00 | 3.758 | 2 | 15 | 164 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 9.34e-03 | 1.00e+00 | 3.749 | 2 | 12 | 165 |
GO:0045662 | negative regulation of myoblast differentiation | 9.87e-03 | 1.00e+00 | 6.656 | 1 | 3 | 11 |
GO:0060391 | positive regulation of SMAD protein import into nucleus | 9.87e-03 | 1.00e+00 | 6.656 | 1 | 4 | 11 |
GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 9.87e-03 | 1.00e+00 | 6.656 | 1 | 2 | 11 |
GO:0016607 | nuclear speck | 1.01e-02 | 1.00e+00 | 3.689 | 2 | 12 | 172 |
GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific) | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 12 |
GO:0006402 | mRNA catabolic process | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 12 |
GO:0097372 | NAD-dependent histone deacetylase activity (H3-K18 specific) | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 12 |
GO:0003714 | transcription corepressor activity | 1.08e-02 | 1.00e+00 | 3.640 | 2 | 11 | 178 |
GO:0070935 | 3'-UTR-mediated mRNA stabilization | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 3 | 12 |
GO:0016580 | Sin3 complex | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 12 |
GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 12 |
GO:0043922 | negative regulation by host of viral transcription | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 12 |
GO:0035198 | miRNA binding | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 12 |
GO:0005515 | protein binding | 1.11e-02 | 1.00e+00 | 0.881 | 10 | 198 | 6024 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 1.15e-02 | 1.00e+00 | 3.592 | 2 | 22 | 184 |
GO:0071480 | cellular response to gamma radiation | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 1 | 13 |
GO:0046969 | NAD-dependent histone deacetylase activity (H3-K9 specific) | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 1 | 13 |
GO:0061647 | histone H3-K9 modification | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 1 | 13 |
GO:0044822 | poly(A) RNA binding | 1.20e-02 | 1.00e+00 | 2.071 | 4 | 50 | 1056 |
GO:0017091 | AU-rich element binding | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 2 | 14 |
GO:0031011 | Ino80 complex | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 6 | 14 |
GO:0043981 | histone H4-K5 acetylation | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 5 | 15 |
GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 3 | 15 |
GO:0001824 | blastocyst development | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 2 | 15 |
GO:0043982 | histone H4-K8 acetylation | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 5 | 15 |
GO:0016581 | NuRD complex | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 2 | 16 |
GO:0043274 | phospholipase binding | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 1 | 16 |
GO:0019731 | antibacterial humoral response | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 1 | 16 |
GO:0045638 | negative regulation of myeloid cell differentiation | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 1 | 16 |
GO:0002227 | innate immune response in mucosa | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 2 | 16 |
GO:0004407 | histone deacetylase activity | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 2 | 16 |
GO:0070933 | histone H4 deacetylation | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 1 | 17 |
GO:0071889 | 14-3-3 protein binding | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 2 | 18 |
GO:0033613 | activating transcription factor binding | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 3 | 18 |
GO:0043984 | histone H4-K16 acetylation | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 5 | 19 |
GO:0008380 | RNA splicing | 1.73e-02 | 1.00e+00 | 3.283 | 2 | 22 | 228 |
GO:0032757 | positive regulation of interleukin-8 production | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 1 | 20 |
GO:0003713 | transcription coactivator activity | 1.86e-02 | 1.00e+00 | 3.227 | 2 | 24 | 237 |
GO:0000123 | histone acetyltransferase complex | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 6 | 21 |
GO:0001106 | RNA polymerase II transcription corepressor activity | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 2 | 21 |
GO:0070932 | histone H3 deacetylation | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 2 | 21 |
GO:0045787 | positive regulation of cell cycle | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 2 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 2 | 22 |
GO:0001205 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 4 | 22 |
GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 2.05e-02 | 1.00e+00 | 5.592 | 1 | 1 | 23 |
GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | 2.23e-02 | 1.00e+00 | 5.472 | 1 | 3 | 25 |
GO:0035329 | hippo signaling | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 5 | 26 |
GO:0051209 | release of sequestered calcium ion into cytosol | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 1 | 26 |
GO:0000976 | transcription regulatory region sequence-specific DNA binding | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 3 | 26 |
GO:0001103 | RNA polymerase II repressing transcription factor binding | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 2 | 27 |
GO:0071339 | MLL1 complex | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 6 | 27 |
GO:0019899 | enzyme binding | 2.49e-02 | 1.00e+00 | 3.002 | 2 | 9 | 277 |
GO:0070491 | repressing transcription factor binding | 2.50e-02 | 1.00e+00 | 5.308 | 1 | 2 | 28 |
GO:0000118 | histone deacetylase complex | 2.50e-02 | 1.00e+00 | 5.308 | 1 | 1 | 28 |
GO:0071897 | DNA biosynthetic process | 2.50e-02 | 1.00e+00 | 5.308 | 1 | 1 | 28 |
GO:0003727 | single-stranded RNA binding | 2.50e-02 | 1.00e+00 | 5.308 | 1 | 2 | 28 |
GO:0010494 | cytoplasmic stress granule | 2.67e-02 | 1.00e+00 | 5.209 | 1 | 2 | 30 |
GO:0043234 | protein complex | 2.80e-02 | 1.00e+00 | 2.911 | 2 | 11 | 295 |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 2.85e-02 | 1.00e+00 | 5.116 | 1 | 2 | 32 |
GO:0005737 | cytoplasm | 3.06e-02 | 1.00e+00 | 1.044 | 7 | 124 | 3767 |
GO:0045786 | negative regulation of cell cycle | 3.46e-02 | 1.00e+00 | 4.830 | 1 | 3 | 39 |
GO:0035019 | somatic stem cell maintenance | 3.55e-02 | 1.00e+00 | 4.794 | 1 | 6 | 40 |
GO:0003723 | RNA binding | 3.68e-02 | 1.00e+00 | 2.698 | 2 | 18 | 342 |
GO:0031124 | mRNA 3'-end processing | 3.72e-02 | 1.00e+00 | 4.723 | 1 | 2 | 42 |
GO:0043565 | sequence-specific DNA binding | 3.76e-02 | 1.00e+00 | 2.681 | 2 | 11 | 346 |
GO:0050830 | defense response to Gram-positive bacterium | 3.98e-02 | 1.00e+00 | 4.624 | 1 | 3 | 45 |
GO:0001047 | core promoter binding | 3.98e-02 | 1.00e+00 | 4.624 | 1 | 5 | 45 |
GO:0006369 | termination of RNA polymerase II transcription | 3.98e-02 | 1.00e+00 | 4.624 | 1 | 2 | 45 |
GO:0043525 | positive regulation of neuron apoptotic process | 4.07e-02 | 1.00e+00 | 4.592 | 1 | 4 | 46 |
GO:0042733 | embryonic digit morphogenesis | 4.16e-02 | 1.00e+00 | 4.561 | 1 | 2 | 47 |
GO:0032922 | circadian regulation of gene expression | 4.33e-02 | 1.00e+00 | 4.501 | 1 | 1 | 49 |
GO:0006986 | response to unfolded protein | 4.42e-02 | 1.00e+00 | 4.472 | 1 | 4 | 50 |
GO:0046982 | protein heterodimerization activity | 4.46e-02 | 1.00e+00 | 2.546 | 2 | 8 | 380 |
GO:0034976 | response to endoplasmic reticulum stress | 4.50e-02 | 1.00e+00 | 4.443 | 1 | 2 | 51 |
GO:0045454 | cell redox homeostasis | 4.50e-02 | 1.00e+00 | 4.443 | 1 | 1 | 51 |
GO:0009611 | response to wounding | 4.59e-02 | 1.00e+00 | 4.415 | 1 | 5 | 52 |
GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 4.68e-02 | 1.00e+00 | 4.388 | 1 | 4 | 53 |
GO:0042475 | odontogenesis of dentin-containing tooth | 4.85e-02 | 1.00e+00 | 4.334 | 1 | 1 | 55 |
GO:0050728 | negative regulation of inflammatory response | 4.93e-02 | 1.00e+00 | 4.308 | 1 | 3 | 56 |
GO:0005730 | nucleolus | 5.15e-02 | 1.00e+00 | 1.435 | 4 | 66 | 1641 |
GO:0006396 | RNA processing | 5.19e-02 | 1.00e+00 | 4.233 | 1 | 5 | 59 |
GO:0000786 | nucleosome | 5.19e-02 | 1.00e+00 | 4.233 | 1 | 2 | 59 |
GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | 5.19e-02 | 1.00e+00 | 4.233 | 1 | 6 | 59 |
GO:0006406 | mRNA export from nucleus | 5.36e-02 | 1.00e+00 | 4.185 | 1 | 4 | 61 |
GO:0006987 | activation of signaling protein activity involved in unfolded protein response | 5.36e-02 | 1.00e+00 | 4.185 | 1 | 2 | 61 |
GO:0006310 | DNA recombination | 5.71e-02 | 1.00e+00 | 4.093 | 1 | 7 | 65 |
GO:0006338 | chromatin remodeling | 5.79e-02 | 1.00e+00 | 4.071 | 1 | 3 | 66 |
GO:0005829 | cytosol | 5.88e-02 | 1.00e+00 | 1.152 | 5 | 86 | 2496 |
GO:0010468 | regulation of gene expression | 5.96e-02 | 1.00e+00 | 4.028 | 1 | 2 | 68 |
GO:0006334 | nucleosome assembly | 6.30e-02 | 1.00e+00 | 3.946 | 1 | 3 | 72 |
GO:0003729 | mRNA binding | 6.30e-02 | 1.00e+00 | 3.946 | 1 | 4 | 72 |
GO:0000785 | chromatin | 6.39e-02 | 1.00e+00 | 3.926 | 1 | 6 | 73 |
GO:0000981 | sequence-specific DNA binding RNA polymerase II transcription factor activity | 6.47e-02 | 1.00e+00 | 3.906 | 1 | 4 | 74 |
GO:0002020 | protease binding | 6.47e-02 | 1.00e+00 | 3.906 | 1 | 6 | 74 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 6.56e-02 | 1.00e+00 | 3.887 | 1 | 1 | 75 |
GO:0071013 | catalytic step 2 spliceosome | 6.81e-02 | 1.00e+00 | 3.830 | 1 | 7 | 78 |
GO:0030968 | endoplasmic reticulum unfolded protein response | 6.89e-02 | 1.00e+00 | 3.812 | 1 | 2 | 79 |
GO:0009653 | anatomical structure morphogenesis | 7.23e-02 | 1.00e+00 | 3.741 | 1 | 2 | 83 |
GO:0090090 | negative regulation of canonical Wnt signaling pathway | 7.48e-02 | 1.00e+00 | 3.689 | 1 | 8 | 86 |
GO:0050821 | protein stabilization | 7.65e-02 | 1.00e+00 | 3.656 | 1 | 3 | 88 |
GO:0005770 | late endosome | 8.07e-02 | 1.00e+00 | 3.576 | 1 | 2 | 93 |
GO:0016568 | chromatin modification | 8.49e-02 | 1.00e+00 | 3.501 | 1 | 4 | 98 |
GO:0030308 | negative regulation of cell growth | 9.48e-02 | 1.00e+00 | 3.334 | 1 | 6 | 110 |
GO:0030529 | ribonucleoprotein complex | 9.64e-02 | 1.00e+00 | 3.308 | 1 | 5 | 112 |
GO:0007219 | Notch signaling pathway | 1.03e-01 | 1.00e+00 | 3.209 | 1 | 5 | 120 |
GO:0007050 | cell cycle arrest | 1.06e-01 | 1.00e+00 | 3.161 | 1 | 5 | 124 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 1.09e-01 | 1.00e+00 | 3.116 | 1 | 11 | 128 |
GO:0016055 | Wnt signaling pathway | 1.18e-01 | 1.00e+00 | 3.007 | 1 | 4 | 138 |
GO:0010628 | positive regulation of gene expression | 1.24e-01 | 1.00e+00 | 2.926 | 1 | 7 | 146 |
GO:0042981 | regulation of apoptotic process | 1.27e-01 | 1.00e+00 | 2.887 | 1 | 4 | 150 |
GO:0007049 | cell cycle | 1.46e-01 | 1.00e+00 | 2.673 | 1 | 6 | 174 |
GO:0005667 | transcription factor complex | 1.47e-01 | 1.00e+00 | 2.664 | 1 | 17 | 175 |
GO:0031625 | ubiquitin protein ligase binding | 1.49e-01 | 1.00e+00 | 2.640 | 1 | 5 | 178 |
GO:0016071 | mRNA metabolic process | 1.83e-01 | 1.00e+00 | 2.315 | 1 | 8 | 223 |
GO:0016020 | membrane | 1.87e-01 | 1.00e+00 | 0.986 | 3 | 46 | 1681 |
GO:0043025 | neuronal cell body | 2.00e-01 | 1.00e+00 | 2.179 | 1 | 9 | 245 |
GO:0016070 | RNA metabolic process | 2.01e-01 | 1.00e+00 | 2.167 | 1 | 8 | 247 |
GO:0000166 | nucleotide binding | 2.10e-01 | 1.00e+00 | 2.099 | 1 | 13 | 259 |
GO:0006281 | DNA repair | 2.11e-01 | 1.00e+00 | 2.088 | 1 | 14 | 261 |
GO:0048011 | neurotrophin TRK receptor signaling pathway | 2.17e-01 | 1.00e+00 | 2.044 | 1 | 7 | 269 |
GO:0005743 | mitochondrial inner membrane | 2.23e-01 | 1.00e+00 | 2.002 | 1 | 6 | 277 |
GO:0006954 | inflammatory response | 2.23e-01 | 1.00e+00 | 2.002 | 1 | 6 | 277 |
GO:0005739 | mitochondrion | 2.26e-01 | 1.00e+00 | 1.153 | 2 | 23 | 998 |
GO:0035556 | intracellular signal transduction | 2.41e-01 | 1.00e+00 | 1.872 | 1 | 9 | 303 |
GO:0019901 | protein kinase binding | 2.51e-01 | 1.00e+00 | 1.807 | 1 | 18 | 317 |
GO:0003682 | chromatin binding | 2.58e-01 | 1.00e+00 | 1.762 | 1 | 19 | 327 |
GO:0008283 | cell proliferation | 2.59e-01 | 1.00e+00 | 1.758 | 1 | 14 | 328 |
GO:0008285 | negative regulation of cell proliferation | 2.75e-01 | 1.00e+00 | 1.652 | 1 | 10 | 353 |
GO:0008284 | positive regulation of cell proliferation | 2.95e-01 | 1.00e+00 | 1.538 | 1 | 10 | 382 |
GO:0000278 | mitotic cell cycle | 3.01e-01 | 1.00e+00 | 1.505 | 1 | 15 | 391 |
GO:0009986 | cell surface | 3.08e-01 | 1.00e+00 | 1.465 | 1 | 9 | 402 |
GO:0043066 | negative regulation of apoptotic process | 3.22e-01 | 1.00e+00 | 1.388 | 1 | 16 | 424 |
GO:0046872 | metal ion binding | 3.32e-01 | 1.00e+00 | 0.764 | 2 | 29 | 1307 |
GO:0007596 | blood coagulation | 3.41e-01 | 1.00e+00 | 1.286 | 1 | 11 | 455 |
GO:0044267 | cellular protein metabolic process | 3.52e-01 | 1.00e+00 | 1.227 | 1 | 20 | 474 |
GO:0042802 | identical protein binding | 3.58e-01 | 1.00e+00 | 1.197 | 1 | 19 | 484 |
GO:0006351 | transcription, DNA-templated | 3.80e-01 | 1.00e+00 | 0.618 | 2 | 57 | 1446 |
GO:0016032 | viral process | 3.88e-01 | 1.00e+00 | 1.055 | 1 | 26 | 534 |
GO:0005887 | integral component of plasma membrane | 5.62e-01 | 1.00e+00 | 0.321 | 1 | 10 | 888 |
GO:0007165 | signal transduction | 5.70e-01 | 1.00e+00 | 0.291 | 1 | 13 | 907 |
GO:0005615 | extracellular space | 5.91e-01 | 1.00e+00 | 0.213 | 1 | 20 | 957 |
GO:0008270 | zinc ion binding | 6.06e-01 | 1.00e+00 | 0.154 | 1 | 27 | 997 |
GO:0070062 | extracellular vesicular exosome | 6.63e-01 | 1.00e+00 | -0.113 | 2 | 57 | 2400 |
GO:0005524 | ATP binding | 7.07e-01 | 1.00e+00 | -0.226 | 1 | 31 | 1298 |