int-snw-57459

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.856 9.97e-16 3.78e-04 2.84e-03
chia-screen-data-Fav-int-snw-57459 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
HCFC1 3054 40-2.9253.44971YesYes
[ GATAD2B ] 57459 1-1.2332.85627--
ZFP36 7538 10-2.9682.86924YesYes
PHB 5245 15-2.7433.004127YesYes
YAP1 10413 94-4.2563.53853Yes-
HDAC1 3065 2-1.7122.869566--
HIST2H2BE 8349 1-1.6002.85698--
BCL6B 255877 2-2.7232.8693YesYes
SRSF3 6428 73-2.9923.53854Yes-
NFRKB 4798 48-3.1293.10823YesYes
POU5F1 5460 133-5.1483.538179YesYes
HNRNPU 3192 76-2.8693.538139Yes-
DDIT3 1649 60-2.8253.504343YesYes

Interactions (15)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
POU5F1 5460 GATAD2B 57459 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse, WangEScmplx
HCFC1 3054 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
HDAC1 3065 BCL6B 255877 pp -- int.I2D: BioGrid
NFRKB 4798 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
HCFC1 3054 HDAC1 3065 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BCI, BioGrid, IntAct;
int.Ravasi: -
HDAC1 3065 PHB 5245 pp -- int.I2D: BioGrid, BCI, HPRD;
int.HPRD: in vivo
HIST2H2BE 8349 GATAD2B 57459 pp -- int.I2D: BioGrid
HDAC1 3065 ZFP36 7538 pp -- int.I2D: BioGrid
DDIT3 1649 HIST2H2BE 8349 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
HDAC1 3065 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
HDAC1 3065 GATAD2B 57459 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo

Related GO terms (216)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm3.95e-085.70e-043.2069641082
GO:0044212transcription regulatory region DNA binding2.41e-073.48e-035.045517168
GO:0006355regulation of transcription, DNA-templated8.76e-061.26e-012.962743997
GO:0005634nucleus9.08e-061.31e-011.546121594559
GO:0003677DNA binding3.28e-054.73e-012.6737491218
GO:0060766negative regulation of androgen receptor signaling pathway5.82e-058.39e-017.4152313
GO:0042789mRNA transcription from RNA polymerase II promoter5.82e-058.39e-017.4152213
GO:0000122negative regulation of transcription from RNA polymerase II promoter9.36e-051.00e+003.283537570
GO:0016575histone deacetylation1.56e-041.00e+006.7232321
GO:0043044ATP-dependent chromatin remodeling1.88e-041.00e+006.5922223
GO:0010467gene expression1.99e-041.00e+003.052545669
GO:0003700sequence-specific DNA binding transcription factor activity2.45e-041.00e+002.988539699
GO:0031492nucleosomal DNA binding2.60e-041.00e+006.3612227
GO:0042594response to starvation3.44e-041.00e+006.1612431
GO:0006366transcription from RNA polymerase II promoter4.08e-041.00e+003.405430419
GO:0060795cell fate commitment involved in formation of primary germ layer9.01e-041.00e+0010.116111
GO:2000016negative regulation of determination of dorsal identity9.01e-041.00e+0010.116111
GO:0090308regulation of methylation-dependent chromatin silencing9.01e-041.00e+0010.116111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway9.01e-041.00e+0010.116111
GO:0060965negative regulation of gene silencing by miRNA9.01e-041.00e+0010.116111
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1.01e-031.00e+005.3882553
GO:0008134transcription factor binding1.18e-031.00e+003.782318242
GO:0060242contact inhibition1.80e-031.00e+009.116112
GO:0019046release from viral latency1.80e-031.00e+009.116122
GO:0009786regulation of asymmetric cell division1.80e-031.00e+009.116112
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.80e-031.00e+009.116112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.80e-031.00e+009.116112
GO:0042826histone deacetylase binding1.85e-031.00e+004.9462472
GO:0061198fungiform papilla formation2.70e-031.00e+008.531113
GO:0060913cardiac cell fate determination2.70e-031.00e+008.531113
GO:0003130BMP signaling pathway involved in heart induction2.70e-031.00e+008.531113
GO:0050779RNA destabilization2.70e-031.00e+008.531113
GO:0001649osteoblast differentiation3.00e-031.00e+004.5922592
GO:0032680regulation of tumor necrosis factor production3.60e-031.00e+008.116114
GO:0045944positive regulation of transcription from RNA polymerase II promoter4.27e-031.00e+002.492441789
GO:0070461SAGA-type complex4.50e-031.00e+007.794125
GO:0001714endodermal cell fate specification4.50e-031.00e+007.794115
GO:0019957C-C chemokine binding4.50e-031.00e+007.794115
GO:0043620regulation of DNA-templated transcription in response to stress4.50e-031.00e+007.794115
GO:0070934CRD-mediated mRNA stabilization4.50e-031.00e+007.794125
GO:0035925mRNA 3'-UTR AU-rich region binding4.50e-031.00e+007.794115
GO:0006325chromatin organization4.88e-031.00e+004.233212118
GO:0045892negative regulation of transcription, DNA-templated5.38e-031.00e+003.011324413
GO:0060789hair follicle placode formation5.40e-031.00e+007.531126
GO:0050847progesterone receptor signaling pathway5.40e-031.00e+007.531126
GO:0019213deacetylase activity5.40e-031.00e+007.531116
GO:2000323negative regulation of glucocorticoid receptor signaling pathway5.40e-031.00e+007.531116
GO:0070937CRD-mediated mRNA stability complex5.40e-031.00e+007.531136
GO:0000790nuclear chromatin5.80e-031.00e+004.10426129
GO:0071354cellular response to interleukin-66.29e-031.00e+007.308127
GO:0010870positive regulation of receptor biosynthetic process6.29e-031.00e+007.308117
GO:0009913epidermal cell differentiation7.19e-031.00e+007.116118
GO:0001955blood vessel maturation7.19e-031.00e+007.116118
GO:0070688MLL5-L complex7.19e-031.00e+007.116118
GO:0043254regulation of protein complex assembly7.19e-031.00e+007.116118
GO:0006974cellular response to DNA damage stimulus7.87e-031.00e+003.87727151
GO:0045893positive regulation of transcription, DNA-templated8.07e-031.00e+002.800324478
GO:0010832negative regulation of myotube differentiation8.09e-031.00e+006.946119
GO:0043995histone acetyltransferase activity (H4-K5 specific)8.09e-031.00e+006.946159
GO:0006476protein deacetylation8.09e-031.00e+006.946119
GO:0046972histone acetyltransferase activity (H4-K16 specific)8.09e-031.00e+006.946159
GO:0035278negative regulation of translation involved in gene silencing by miRNA8.09e-031.00e+006.946119
GO:0048188Set1C/COMPASS complex8.09e-031.00e+006.946149
GO:0006983ER overload response8.09e-031.00e+006.946119
GO:0010944negative regulation of transcription by competitive promoter binding8.09e-031.00e+006.946119
GO:0043996histone acetyltransferase activity (H4-K8 specific)8.09e-031.00e+006.946159
GO:0033558protein deacetylase activity8.09e-031.00e+006.946119
GO:0035413positive regulation of catenin import into nucleus8.98e-031.00e+006.7941210
GO:0061029eyelid development in camera-type eye8.98e-031.00e+006.7941210
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay8.98e-031.00e+006.7941210
GO:0000398mRNA splicing, via spliceosome9.23e-031.00e+003.758215164
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9.34e-031.00e+003.749212165
GO:0045662negative regulation of myoblast differentiation9.87e-031.00e+006.6561311
GO:0060391positive regulation of SMAD protein import into nucleus9.87e-031.00e+006.6561411
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening9.87e-031.00e+006.6561211
GO:0016607nuclear speck1.01e-021.00e+003.689212172
GO:0046970NAD-dependent histone deacetylase activity (H4-K16 specific)1.08e-021.00e+006.5311112
GO:0006402mRNA catabolic process1.08e-021.00e+006.5311112
GO:0097372NAD-dependent histone deacetylase activity (H3-K18 specific)1.08e-021.00e+006.5311112
GO:0003714transcription corepressor activity1.08e-021.00e+003.640211178
GO:00709353'-UTR-mediated mRNA stabilization1.08e-021.00e+006.5311312
GO:0016580Sin3 complex1.08e-021.00e+006.5311112
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)1.08e-021.00e+006.5311112
GO:0043922negative regulation by host of viral transcription1.08e-021.00e+006.5311112
GO:0035198miRNA binding1.08e-021.00e+006.5311112
GO:0005515protein binding1.11e-021.00e+000.881101986024
GO:0006367transcription initiation from RNA polymerase II promoter1.15e-021.00e+003.592222184
GO:0071480cellular response to gamma radiation1.17e-021.00e+006.4151113
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)1.17e-021.00e+006.4151113
GO:0061647histone H3-K9 modification1.17e-021.00e+006.4151113
GO:0044822poly(A) RNA binding1.20e-021.00e+002.0714501056
GO:0017091AU-rich element binding1.26e-021.00e+006.3081214
GO:0031011Ino80 complex1.26e-021.00e+006.3081614
GO:0043981histone H4-K5 acetylation1.34e-021.00e+006.2091515
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.34e-021.00e+006.2091315
GO:0001824blastocyst development1.34e-021.00e+006.2091215
GO:0043982histone H4-K8 acetylation1.34e-021.00e+006.2091515
GO:0016581NuRD complex1.43e-021.00e+006.1161216
GO:0043274phospholipase binding1.43e-021.00e+006.1161116
GO:0019731antibacterial humoral response1.43e-021.00e+006.1161116
GO:0045638negative regulation of myeloid cell differentiation1.43e-021.00e+006.1161116
GO:0002227innate immune response in mucosa1.43e-021.00e+006.1161216
GO:0004407histone deacetylase activity1.43e-021.00e+006.1161216
GO:0070933histone H4 deacetylation1.52e-021.00e+006.0281117
GO:007188914-3-3 protein binding1.61e-021.00e+005.9461218
GO:0033613activating transcription factor binding1.61e-021.00e+005.9461318
GO:0043984histone H4-K16 acetylation1.70e-021.00e+005.8681519
GO:0008380RNA splicing1.73e-021.00e+003.283222228
GO:0032757positive regulation of interleukin-8 production1.79e-021.00e+005.7941120
GO:0003713transcription coactivator activity1.86e-021.00e+003.227224237
GO:0000123histone acetyltransferase complex1.88e-021.00e+005.7231621
GO:0001106RNA polymerase II transcription corepressor activity1.88e-021.00e+005.7231221
GO:0070932histone H3 deacetylation1.88e-021.00e+005.7231221
GO:0045787positive regulation of cell cycle1.97e-021.00e+005.6561222
GO:0036464cytoplasmic ribonucleoprotein granule1.97e-021.00e+005.6561222
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription1.97e-021.00e+005.6561422
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress2.05e-021.00e+005.5921123
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening2.23e-021.00e+005.4721325
GO:0035329hippo signaling2.32e-021.00e+005.4151526
GO:0051209release of sequestered calcium ion into cytosol2.32e-021.00e+005.4151126
GO:0000976transcription regulatory region sequence-specific DNA binding2.32e-021.00e+005.4151326
GO:0001103RNA polymerase II repressing transcription factor binding2.41e-021.00e+005.3611227
GO:0071339MLL1 complex2.41e-021.00e+005.3611627
GO:0019899enzyme binding2.49e-021.00e+003.00229277
GO:0070491repressing transcription factor binding2.50e-021.00e+005.3081228
GO:0000118histone deacetylase complex2.50e-021.00e+005.3081128
GO:0071897DNA biosynthetic process2.50e-021.00e+005.3081128
GO:0003727single-stranded RNA binding2.50e-021.00e+005.3081228
GO:0010494cytoplasmic stress granule2.67e-021.00e+005.2091230
GO:0043234protein complex2.80e-021.00e+002.911211295
GO:1903507negative regulation of nucleic acid-templated transcription2.85e-021.00e+005.1161232
GO:0005737cytoplasm3.06e-021.00e+001.04471243767
GO:0045786negative regulation of cell cycle3.46e-021.00e+004.8301339
GO:0035019somatic stem cell maintenance3.55e-021.00e+004.7941640
GO:0003723RNA binding3.68e-021.00e+002.698218342
GO:0031124mRNA 3'-end processing3.72e-021.00e+004.7231242
GO:0043565sequence-specific DNA binding3.76e-021.00e+002.681211346
GO:0050830defense response to Gram-positive bacterium3.98e-021.00e+004.6241345
GO:0001047core promoter binding3.98e-021.00e+004.6241545
GO:0006369termination of RNA polymerase II transcription3.98e-021.00e+004.6241245
GO:0043525positive regulation of neuron apoptotic process4.07e-021.00e+004.5921446
GO:0042733embryonic digit morphogenesis4.16e-021.00e+004.5611247
GO:0032922circadian regulation of gene expression4.33e-021.00e+004.5011149
GO:0006986response to unfolded protein4.42e-021.00e+004.4721450
GO:0046982protein heterodimerization activity4.46e-021.00e+002.54628380
GO:0034976response to endoplasmic reticulum stress4.50e-021.00e+004.4431251
GO:0045454cell redox homeostasis4.50e-021.00e+004.4431151
GO:0009611response to wounding4.59e-021.00e+004.4151552
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay4.68e-021.00e+004.3881453
GO:0042475odontogenesis of dentin-containing tooth4.85e-021.00e+004.3341155
GO:0050728negative regulation of inflammatory response4.93e-021.00e+004.3081356
GO:0005730nucleolus5.15e-021.00e+001.4354661641
GO:0006396RNA processing5.19e-021.00e+004.2331559
GO:0000786nucleosome5.19e-021.00e+004.2331259
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity5.19e-021.00e+004.2331659
GO:0006406mRNA export from nucleus5.36e-021.00e+004.1851461
GO:0006987activation of signaling protein activity involved in unfolded protein response5.36e-021.00e+004.1851261
GO:0006310DNA recombination5.71e-021.00e+004.0931765
GO:0006338chromatin remodeling5.79e-021.00e+004.0711366
GO:0005829cytosol5.88e-021.00e+001.1525862496
GO:0010468regulation of gene expression5.96e-021.00e+004.0281268
GO:0006334nucleosome assembly6.30e-021.00e+003.9461372
GO:0003729mRNA binding6.30e-021.00e+003.9461472
GO:0000785chromatin6.39e-021.00e+003.9261673
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity6.47e-021.00e+003.9061474
GO:0002020protease binding6.47e-021.00e+003.9061674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.56e-021.00e+003.8871175
GO:0071013catalytic step 2 spliceosome6.81e-021.00e+003.8301778
GO:0030968endoplasmic reticulum unfolded protein response6.89e-021.00e+003.8121279
GO:0009653anatomical structure morphogenesis7.23e-021.00e+003.7411283
GO:0090090negative regulation of canonical Wnt signaling pathway7.48e-021.00e+003.6891886
GO:0050821protein stabilization7.65e-021.00e+003.6561388
GO:0005770late endosome8.07e-021.00e+003.5761293
GO:0016568chromatin modification8.49e-021.00e+003.5011498
GO:0030308negative regulation of cell growth9.48e-021.00e+003.33416110
GO:0030529ribonucleoprotein complex9.64e-021.00e+003.30815112
GO:0007219Notch signaling pathway1.03e-011.00e+003.20915120
GO:0007050cell cycle arrest1.06e-011.00e+003.16115124
GO:0007179transforming growth factor beta receptor signaling pathway1.09e-011.00e+003.116111128
GO:0016055Wnt signaling pathway1.18e-011.00e+003.00714138
GO:0010628positive regulation of gene expression1.24e-011.00e+002.92617146
GO:0042981regulation of apoptotic process1.27e-011.00e+002.88714150
GO:0007049cell cycle1.46e-011.00e+002.67316174
GO:0005667transcription factor complex1.47e-011.00e+002.664117175
GO:0031625ubiquitin protein ligase binding1.49e-011.00e+002.64015178
GO:0016071mRNA metabolic process1.83e-011.00e+002.31518223
GO:0016020membrane1.87e-011.00e+000.9863461681
GO:0043025neuronal cell body2.00e-011.00e+002.17919245
GO:0016070RNA metabolic process2.01e-011.00e+002.16718247
GO:0000166nucleotide binding2.10e-011.00e+002.099113259
GO:0006281DNA repair2.11e-011.00e+002.088114261
GO:0048011neurotrophin TRK receptor signaling pathway2.17e-011.00e+002.04417269
GO:0005743mitochondrial inner membrane2.23e-011.00e+002.00216277
GO:0006954inflammatory response2.23e-011.00e+002.00216277
GO:0005739mitochondrion2.26e-011.00e+001.153223998
GO:0035556intracellular signal transduction2.41e-011.00e+001.87219303
GO:0019901protein kinase binding2.51e-011.00e+001.807118317
GO:0003682chromatin binding2.58e-011.00e+001.762119327
GO:0008283cell proliferation2.59e-011.00e+001.758114328
GO:0008285negative regulation of cell proliferation2.75e-011.00e+001.652110353
GO:0008284positive regulation of cell proliferation2.95e-011.00e+001.538110382
GO:0000278mitotic cell cycle3.01e-011.00e+001.505115391
GO:0009986cell surface3.08e-011.00e+001.46519402
GO:0043066negative regulation of apoptotic process3.22e-011.00e+001.388116424
GO:0046872metal ion binding3.32e-011.00e+000.7642291307
GO:0007596blood coagulation3.41e-011.00e+001.286111455
GO:0044267cellular protein metabolic process3.52e-011.00e+001.227120474
GO:0042802identical protein binding3.58e-011.00e+001.197119484
GO:0006351transcription, DNA-templated3.80e-011.00e+000.6182571446
GO:0016032viral process3.88e-011.00e+001.055126534
GO:0005887integral component of plasma membrane5.62e-011.00e+000.321110888
GO:0007165signal transduction5.70e-011.00e+000.291113907
GO:0005615extracellular space5.91e-011.00e+000.213120957
GO:0008270zinc ion binding6.06e-011.00e+000.154127997
GO:0070062extracellular vesicular exosome6.63e-011.00e+00-0.1132572400
GO:0005524ATP binding7.07e-011.00e+00-0.2261311298