int-snw-54934

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.863	8.37e-16	3.47e-04	2.67e-03

chia-screen-data-Fav-int-snw-54934 subnetwork

Genes (14)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
MED19	219541	30	-2.657	3.449	115	Yes	-
MCRS1	10445	14	-2.660	3.079	63	Yes	Yes
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
MED28	80306	16	-2.404	3.216	80	Yes	-
MED13L	23389	12	-2.550	3.159	21	Yes	-
MED24	9862	6	-2.482	3.033	39	Yes	-
MED12	9968	14	-2.465	3.206	65	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
[ KANSL2 ]	54934	1	-1.149	2.863	3	-	-
MED14	9282	6	-2.420	3.137	49	Yes	-
INO80E	283899	10	-2.663	3.079	20	Yes	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
YY1	7528	24	-2.572	3.120	114	Yes	Yes

Interactions (23)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
NFRKB	4798	YY1	7528	pp	--	int.I2D: BioGrid
MED28	80306	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MED24	9862	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MED12	9968	MED28	80306	pp	--	int.I2D: BioGrid
MED12	9968	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
YAP1	10413	MED28	80306	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
MCRS1	10445	INO80E	283899	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MED24	9862	MED28	80306	pp	--	int.I2D: BioGrid
MED14	9282	MED12	9968	pp	--	int.I2D: BioGrid
NFRKB	4798	INO80E	283899	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
MED24	9862	MED12	9968	pp	--	int.I2D: BioGrid
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
KANSL2	54934	MED28	80306	pp	--	int.I2D: MINT_Fly, BioGrid_Fly, BIND_Fly, FlyLow, IntAct_Fly
YY1	7528	INO80E	283899	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
NFRKB	4798	MCRS1	10445	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
MED14	9282	MED28	80306	pp	--	int.I2D: BioGrid
MED14	9282	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MCRS1	10445	KANSL2	54934	pp	--	int.I2D: BioGrid_Fly, BIND, BIND_Fly, FlyLow, IntAct_Fly, MINT_Fly
MED13L	23389	MED28	80306	pp	--	int.I2D: BioGrid
YY1	7528	MCRS1	10445	pp	--	int.I2D: BioGrid
MED13L	23389	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MED14	9282	MED24	9862	pp	--	int.I2D: BioGrid

Related GO terms (119)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016592	mediator complex	3.85e-13	5.55e-09	7.464	6	10	35
GO:0001104	RNA polymerase II transcription cofactor activity	9.01e-11	1.30e-06	7.286	5	8	33
GO:0031011	Ino80 complex	5.53e-10	7.97e-06	8.201	4	6	14
GO:0019827	stem cell maintenance	9.67e-08	1.40e-03	6.454	4	7	47
GO:0030518	intracellular steroid hormone receptor signaling pathway	2.63e-07	3.80e-03	7.786	3	6	14
GO:0042809	vitamin D receptor binding	3.29e-07	4.75e-03	7.687	3	6	15
GO:0046966	thyroid hormone receptor binding	1.87e-06	2.69e-02	6.893	3	6	26
GO:0006357	regulation of transcription from RNA polymerase II promoter	3.46e-06	4.99e-02	4.286	5	23	264
GO:0030521	androgen receptor signaling pathway	7.59e-06	1.10e-01	6.236	3	5	41
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	8.78e-06	1.27e-01	6.167	3	7	43
GO:0003712	transcription cofactor activity	9.42e-06	1.36e-01	6.134	3	8	44
GO:0006367	transcription initiation from RNA polymerase II promoter	2.32e-05	3.35e-01	4.485	4	22	184
GO:0005654	nucleoplasm	2.82e-05	4.06e-01	2.737	7	64	1082
GO:0006310	DNA recombination	3.07e-05	4.43e-01	5.571	3	7	65
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	3.14e-05	4.53e-01	7.839	2	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	3.14e-05	4.53e-01	7.839	2	5	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	3.14e-05	4.53e-01	7.839	2	5	9
GO:0003713	transcription coactivator activity	6.25e-05	9.02e-01	4.120	4	24	237
GO:0043981	histone H4-K5 acetylation	9.12e-05	1.00e+00	7.102	2	5	15
GO:0043982	histone H4-K8 acetylation	9.12e-05	1.00e+00	7.102	2	5	15
GO:0043984	histone H4-K16 acetylation	1.48e-04	1.00e+00	6.761	2	5	19
GO:0000123	histone acetyltransferase complex	1.82e-04	1.00e+00	6.616	2	6	21
GO:0006355	regulation of transcription, DNA-templated	1.99e-04	1.00e+00	2.632	6	43	997
GO:0005634	nucleus	4.09e-04	1.00e+00	1.314	11	159	4559
GO:0044212	transcription regulatory region DNA binding	5.14e-04	1.00e+00	4.201	3	17	168
GO:0006366	transcription from RNA polymerase II promoter	5.58e-04	1.00e+00	3.298	4	30	419
GO:0004872	receptor activity	7.25e-04	1.00e+00	4.031	3	8	189
GO:0060795	cell fate commitment involved in formation of primary germ layer	9.71e-04	1.00e+00	10.009	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	9.71e-04	1.00e+00	10.009	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	9.71e-04	1.00e+00	10.009	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	9.71e-04	1.00e+00	10.009	1	1	1
GO:0006281	DNA repair	1.84e-03	1.00e+00	3.566	3	14	261
GO:0034696	response to prostaglandin F	1.94e-03	1.00e+00	9.009	1	1	2
GO:0009786	regulation of asymmetric cell division	1.94e-03	1.00e+00	9.009	1	1	2
GO:0060242	contact inhibition	1.94e-03	1.00e+00	9.009	1	1	2
GO:0006403	RNA localization	1.94e-03	1.00e+00	9.009	1	1	2
GO:0060913	cardiac cell fate determination	2.91e-03	1.00e+00	8.424	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.91e-03	1.00e+00	8.424	1	1	3
GO:0090245	axis elongation involved in somitogenesis	2.91e-03	1.00e+00	8.424	1	1	3
GO:0010467	gene expression	3.16e-03	1.00e+00	2.623	4	45	669
GO:0014044	Schwann cell development	3.88e-03	1.00e+00	8.009	1	1	4
GO:0051151	negative regulation of smooth muscle cell differentiation	3.88e-03	1.00e+00	8.009	1	1	4
GO:0001714	endodermal cell fate specification	4.84e-03	1.00e+00	7.687	1	1	5
GO:0006325	chromatin organization	5.66e-03	1.00e+00	4.126	2	12	118
GO:0000400	four-way junction DNA binding	8.70e-03	1.00e+00	6.839	1	1	9
GO:0010225	response to UV-C	8.70e-03	1.00e+00	6.839	1	2	9
GO:0006974	cellular response to DNA damage stimulus	9.12e-03	1.00e+00	3.770	2	7	151
GO:0035413	positive regulation of catenin import into nucleus	9.67e-03	1.00e+00	6.687	1	2	10
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	9.67e-03	1.00e+00	6.687	1	1	10
GO:0045893	positive regulation of transcription, DNA-templated	1.00e-02	1.00e+00	2.693	3	24	478
GO:0060391	positive regulation of SMAD protein import into nucleus	1.06e-02	1.00e+00	6.549	1	4	11
GO:0035198	miRNA binding	1.16e-02	1.00e+00	6.424	1	1	12
GO:0005667	transcription factor complex	1.21e-02	1.00e+00	3.558	2	17	175
GO:0003714	transcription corepressor activity	1.25e-02	1.00e+00	3.533	2	11	178
GO:0071480	cellular response to gamma radiation	1.26e-02	1.00e+00	6.308	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	1.26e-02	1.00e+00	6.308	1	2	13
GO:0005685	U1 snRNP	1.35e-02	1.00e+00	6.201	1	1	14
GO:0006376	mRNA splice site selection	1.45e-02	1.00e+00	6.102	1	1	15
GO:0001824	blastocyst development	1.45e-02	1.00e+00	6.102	1	2	15
GO:0048593	camera-type eye morphogenesis	1.54e-02	1.00e+00	6.009	1	1	16
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	1.54e-02	1.00e+00	6.009	1	2	16
GO:0051276	chromosome organization	1.54e-02	1.00e+00	6.009	1	2	16
GO:0014003	oligodendrocyte development	1.92e-02	1.00e+00	5.687	1	5	20
GO:0016573	histone acetylation	2.21e-02	1.00e+00	5.485	1	2	23
GO:0030864	cortical actin cytoskeleton	2.21e-02	1.00e+00	5.485	1	1	23
GO:0031519	PcG protein complex	2.40e-02	1.00e+00	5.365	1	1	25
GO:0005515	protein binding	2.44e-02	1.00e+00	0.774	10	198	6024
GO:0035329	hippo signaling	2.50e-02	1.00e+00	5.308	1	5	26
GO:0003677	DNA binding	2.55e-02	1.00e+00	1.758	4	49	1218
GO:0071339	MLL1 complex	2.59e-02	1.00e+00	5.254	1	6	27
GO:0034644	cellular response to UV	2.87e-02	1.00e+00	5.102	1	1	30
GO:1903507	negative regulation of nucleic acid-templated transcription	3.06e-02	1.00e+00	5.009	1	2	32
GO:0030178	negative regulation of Wnt signaling pathway	3.35e-02	1.00e+00	4.879	1	4	35
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.78e-02	1.00e+00	1.970	3	41	789
GO:0035019	somatic stem cell maintenance	3.82e-02	1.00e+00	4.687	1	6	40
GO:0004402	histone acetyltransferase activity	4.10e-02	1.00e+00	4.582	1	6	43
GO:0006351	transcription, DNA-templated	4.44e-02	1.00e+00	1.511	4	57	1446
GO:0009611	response to wounding	4.93e-02	1.00e+00	4.308	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	5.03e-02	1.00e+00	4.281	1	5	53
GO:0000724	double-strand break repair via homologous recombination	5.21e-02	1.00e+00	4.227	1	2	55
GO:0051291	protein heterooligomerization	5.30e-02	1.00e+00	4.201	1	4	56
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	5.58e-02	1.00e+00	4.126	1	5	59
GO:0008013	beta-catenin binding	5.67e-02	1.00e+00	4.102	1	9	60
GO:0010468	regulation of gene expression	6.40e-02	1.00e+00	3.921	1	2	68
GO:0005730	nucleolus	6.58e-02	1.00e+00	1.328	4	66	1641
GO:0003729	mRNA binding	6.77e-02	1.00e+00	3.839	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	6.95e-02	1.00e+00	3.799	1	4	74
GO:0001843	neural tube closure	6.95e-02	1.00e+00	3.799	1	2	74
GO:0002020	protease binding	6.95e-02	1.00e+00	3.799	1	6	74
GO:0060070	canonical Wnt signaling pathway	7.04e-02	1.00e+00	3.780	1	4	75
GO:0009653	anatomical structure morphogenesis	7.77e-02	1.00e+00	3.634	1	2	83
GO:0009952	anterior/posterior pattern specification	7.77e-02	1.00e+00	3.634	1	4	83
GO:0006464	cellular protein modification process	7.86e-02	1.00e+00	3.616	1	4	84
GO:0016363	nuclear matrix	8.48e-02	1.00e+00	3.501	1	6	91
GO:0006260	DNA replication	1.11e-01	1.00e+00	3.090	1	3	121
GO:0007507	heart development	1.27e-01	1.00e+00	2.890	1	7	139
GO:0003700	sequence-specific DNA binding transcription factor activity	1.45e-01	1.00e+00	1.560	2	39	699
GO:0008022	protein C-terminus binding	1.45e-01	1.00e+00	2.678	1	8	161
GO:0016607	nuclear speck	1.55e-01	1.00e+00	2.582	1	12	172
GO:0031625	ubiquitin protein ligase binding	1.60e-01	1.00e+00	2.533	1	5	178
GO:0019904	protein domain specific binding	1.60e-01	1.00e+00	2.525	1	8	179
GO:0008380	RNA splicing	2.00e-01	1.00e+00	2.176	1	22	228
GO:0008134	transcription factor binding	2.11e-01	1.00e+00	2.090	1	18	242
GO:0016020	membrane	2.18e-01	1.00e+00	0.879	3	46	1681
GO:0007283	spermatogenesis	2.26e-01	1.00e+00	1.975	1	3	262
GO:0003779	actin binding	2.30e-01	1.00e+00	1.953	1	10	266
GO:0006954	inflammatory response	2.38e-01	1.00e+00	1.895	1	6	277
GO:0030154	cell differentiation	2.56e-01	1.00e+00	1.775	1	5	301
GO:0044822	poly(A) RNA binding	2.74e-01	1.00e+00	0.964	2	50	1056
GO:0003682	chromatin binding	2.75e-01	1.00e+00	1.656	1	19	327
GO:0008283	cell proliferation	2.75e-01	1.00e+00	1.651	1	14	328
GO:0003723	RNA binding	2.85e-01	1.00e+00	1.591	1	18	342
GO:0043565	sequence-specific DNA binding	2.88e-01	1.00e+00	1.574	1	11	346
GO:0005925	focal adhesion	3.02e-01	1.00e+00	1.493	1	9	366
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	4.32e-01	1.00e+00	0.854	1	37	570
GO:0008270	zinc ion binding	6.33e-01	1.00e+00	0.047	1	27	997
GO:0005829	cytosol	7.25e-01	1.00e+00	-0.277	2	86	2496
GO:0005737	cytoplasm	7.50e-01	1.00e+00	-0.286	3	124	3767
GO:0005886	plasma membrane	9.37e-01	1.00e+00	-1.326	1	49	2582

chia-Fav

int-snw-54934

Statistics

Genes (14)

Interactions (23)

Related GO terms (119)