int-snw-54857

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.797 4.17e-15 7.53e-04 4.63e-03
chia-screen-data-Fav-int-snw-54857 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
HCFC1 3054 40-2.9253.44971YesYes
TUBB4A 10382 7-2.3122.97588Yes-
ZFP36 7538 10-2.9682.86924YesYes
NFKB1 4790 9-2.1232.870263Yes-
[ GDPD2 ] 54857 1-1.2552.7974--
HEXDC 284004 1-1.4782.79710--
YAP1 10413 94-4.2563.53853Yes-
SRSF3 6428 73-2.9923.53854Yes-
NFRKB 4798 48-3.1293.10823YesYes
POU5F1 5460 133-5.1483.538179YesYes
HNRNPU 3192 76-2.8693.538139Yes-
DDIT3 1649 60-2.8253.504343YesYes
MAP3K1 4214 3-2.0882.975123Yes-

Interactions (15)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
NFRKB 4798 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
TUBB4A 10382 HEXDC 284004 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
HCFC1 3054 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
NFKB1 4790 ZFP36 7538 pp -- int.I2D: BioGrid
DDIT3 1649 NFKB1 4790 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
NFKB1 4790 TUBB4A 10382 pp -- int.I2D: MINT;
int.Mint: MI:0915(physical association)
POU5F1 5460 TUBB4A 10382 pp -- int.I2D: BioGrid
DDIT3 1649 TUBB4A 10382 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
MAP3K1 4214 TUBB4A 10382 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, MINT;
int.Mint: MI:0915(physical association)
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
GDPD2 54857 HEXDC 284004 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, MINT, StelzlMedium, HPRD, IntAct;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
DDIT3 1649 HNRNPU 3192 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
NFKB1 4790 NFRKB 4798 pp -- int.I2D: BCI, HPRD;
int.Ravasi: -;
int.HPRD: in vitro

Related GO terms (227)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0044212transcription regulatory region DNA binding1.17e-051.69e-014.723417168
GO:0005654nucleoplasm1.51e-052.17e-012.8447641082
GO:0006366transcription from RNA polymerase II promoter2.14e-053.09e-013.727530419
GO:0042789mRNA transcription from RNA polymerase II promoter5.82e-058.39e-017.4152213
GO:0042594response to starvation3.44e-041.00e+006.1612431
GO:0060795cell fate commitment involved in formation of primary germ layer9.01e-041.00e+0010.116111
GO:0047394glycerophosphoinositol inositolphosphodiesterase activity9.01e-041.00e+0010.116111
GO:2000016negative regulation of determination of dorsal identity9.01e-041.00e+0010.116111
GO:0045083negative regulation of interleukin-12 biosynthetic process9.01e-041.00e+0010.116111
GO:0090308regulation of methylation-dependent chromatin silencing9.01e-041.00e+0010.116111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway9.01e-041.00e+0010.116111
GO:0060965negative regulation of gene silencing by miRNA9.01e-041.00e+0010.116111
GO:0005634nucleus1.03e-031.00e+001.283101594559
GO:0050728negative regulation of inflammatory response1.12e-031.00e+005.3082356
GO:0008134transcription factor binding1.18e-031.00e+003.782318242
GO:0006355regulation of transcription, DNA-templated1.26e-031.00e+002.476543997
GO:0034146toll-like receptor 5 signaling pathway1.51e-031.00e+005.0932465
GO:0071260cellular response to mechanical stimulus1.51e-031.00e+005.0932465
GO:0034166toll-like receptor 10 signaling pathway1.51e-031.00e+005.0932465
GO:0060242contact inhibition1.80e-031.00e+009.116112
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway1.80e-031.00e+004.9662471
GO:0019046release from viral latency1.80e-031.00e+009.116122
GO:0009786regulation of asymmetric cell division1.80e-031.00e+009.116112
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway1.80e-031.00e+004.9662471
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.80e-031.00e+009.116112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.80e-031.00e+009.116112
GO:0034162toll-like receptor 9 signaling pathway1.85e-031.00e+004.9462472
GO:0034134toll-like receptor 2 signaling pathway1.90e-031.00e+004.9262473
GO:0005515protein binding2.00e-031.00e+001.019111986024
GO:0002755MyD88-dependent toll-like receptor signaling pathway2.28e-031.00e+004.7942580
GO:0010467gene expression2.34e-031.00e+002.730445669
GO:0004563beta-N-acetylhexosaminidase activity2.70e-031.00e+008.531113
GO:0033256I-kappaB/NF-kappaB complex2.70e-031.00e+008.531113
GO:0008889glycerophosphodiester phosphodiesterase activity2.70e-031.00e+008.531113
GO:0008545JUN kinase kinase activity2.70e-031.00e+008.531113
GO:0060913cardiac cell fate determination2.70e-031.00e+008.531113
GO:0003130BMP signaling pathway involved in heart induction2.70e-031.00e+008.531113
GO:1900127positive regulation of hyaluronan biosynthetic process2.70e-031.00e+008.531113
GO:0050779RNA destabilization2.70e-031.00e+008.531113
GO:0010956negative regulation of calcidiol 1-monooxygenase activity2.70e-031.00e+008.531113
GO:0003700sequence-specific DNA binding transcription factor activity2.75e-031.00e+002.666439699
GO:0005829cytosol2.99e-031.00e+001.6387862496
GO:0003677DNA binding3.08e-031.00e+002.1875491218
GO:0034142toll-like receptor 4 signaling pathway3.26e-031.00e+004.5312496
GO:0032680regulation of tumor necrosis factor production3.60e-031.00e+008.116114
GO:0010957negative regulation of vitamin D biosynthetic process3.60e-031.00e+008.116114
GO:0032375negative regulation of cholesterol transport3.60e-031.00e+008.116114
GO:0032269negative regulation of cellular protein metabolic process3.60e-031.00e+008.116114
GO:2000630positive regulation of miRNA metabolic process3.60e-031.00e+008.116114
GO:0033269internode region of axon3.60e-031.00e+008.116114
GO:0002224toll-like receptor signaling pathway4.18e-031.00e+004.34724109
GO:0045944positive regulation of transcription from RNA polymerase II promoter4.27e-031.00e+002.492441789
GO:0070461SAGA-type complex4.50e-031.00e+007.794125
GO:0001714endodermal cell fate specification4.50e-031.00e+007.794115
GO:0019957C-C chemokine binding4.50e-031.00e+007.794115
GO:0043620regulation of DNA-templated transcription in response to stress4.50e-031.00e+007.794115
GO:0070934CRD-mediated mRNA stabilization4.50e-031.00e+007.794125
GO:0010884positive regulation of lipid storage4.50e-031.00e+007.794115
GO:0035925mRNA 3'-UTR AU-rich region binding4.50e-031.00e+007.794115
GO:0070937CRD-mediated mRNA stability complex5.40e-031.00e+007.531136
GO:0071354cellular response to interleukin-66.29e-031.00e+007.308127
GO:0001955blood vessel maturation7.19e-031.00e+007.116118
GO:0071316cellular response to nicotine7.19e-031.00e+007.116118
GO:0070688MLL5-L complex7.19e-031.00e+007.116118
GO:0043254regulation of protein complex assembly7.19e-031.00e+007.116118
GO:0005737cytoplasm7.50e-031.00e+001.23681243767
GO:0006974cellular response to DNA damage stimulus7.87e-031.00e+003.87727151
GO:0043995histone acetyltransferase activity (H4-K5 specific)8.09e-031.00e+006.946159
GO:0046972histone acetyltransferase activity (H4-K16 specific)8.09e-031.00e+006.946159
GO:0035278negative regulation of translation involved in gene silencing by miRNA8.09e-031.00e+006.946119
GO:0048188Set1C/COMPASS complex8.09e-031.00e+006.946149
GO:0006983ER overload response8.09e-031.00e+006.946119
GO:0003382epithelial cell morphogenesis8.09e-031.00e+006.946119
GO:0000975regulatory region DNA binding8.09e-031.00e+006.946129
GO:0043996histone acetyltransferase activity (H4-K8 specific)8.09e-031.00e+006.946159
GO:0006071glycerol metabolic process8.09e-031.00e+006.946119
GO:0035413positive regulation of catenin import into nucleus8.98e-031.00e+006.7941210
GO:0061029eyelid development in camera-type eye8.98e-031.00e+006.7941210
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay8.98e-031.00e+006.7941210
GO:0000398mRNA splicing, via spliceosome9.23e-031.00e+003.758215164
GO:0038095Fc-epsilon receptor signaling pathway9.67e-031.00e+003.72325168
GO:0045662negative regulation of myoblast differentiation9.87e-031.00e+006.6561311
GO:0060391positive regulation of SMAD protein import into nucleus9.87e-031.00e+006.6561411
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening9.87e-031.00e+006.6561211
GO:0006402mRNA catabolic process1.08e-021.00e+006.5311112
GO:0003714transcription corepressor activity1.08e-021.00e+003.640211178
GO:00709353'-UTR-mediated mRNA stabilization1.08e-021.00e+006.5311312
GO:0035198miRNA binding1.08e-021.00e+006.5311112
GO:0071480cellular response to gamma radiation1.17e-021.00e+006.4151113
GO:0046688response to copper ion1.17e-021.00e+006.4151113
GO:0044822poly(A) RNA binding1.20e-021.00e+002.0714501056
GO:0010744positive regulation of macrophage derived foam cell differentiation1.26e-021.00e+006.3081114
GO:0031293membrane protein intracellular domain proteolysis1.26e-021.00e+006.3081114
GO:0017091AU-rich element binding1.26e-021.00e+006.3081214
GO:0031011Ino80 complex1.26e-021.00e+006.3081614
GO:0071375cellular response to peptide hormone stimulus1.26e-021.00e+006.3081214
GO:0000122negative regulation of transcription from RNA polymerase II promoter1.31e-021.00e+002.546337570
GO:0043981histone H4-K5 acetylation1.34e-021.00e+006.2091515
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.34e-021.00e+006.2091315
GO:0001824blastocyst development1.34e-021.00e+006.2091215
GO:0043982histone H4-K8 acetylation1.34e-021.00e+006.2091515
GO:0043274phospholipase binding1.43e-021.00e+006.1161116
GO:0043209myelin sheath1.43e-021.00e+006.1161116
GO:0045638negative regulation of myeloid cell differentiation1.43e-021.00e+006.1161116
GO:0004709MAP kinase kinase kinase activity1.61e-021.00e+005.9461218
GO:007188914-3-3 protein binding1.61e-021.00e+005.9461218
GO:0043984histone H4-K16 acetylation1.70e-021.00e+005.8681519
GO:0008380RNA splicing1.73e-021.00e+003.283222228
GO:0032757positive regulation of interleukin-8 production1.79e-021.00e+005.7941120
GO:0003713transcription coactivator activity1.86e-021.00e+003.227224237
GO:0000123histone acetyltransferase complex1.88e-021.00e+005.7231621
GO:0008637apoptotic mitochondrial changes1.88e-021.00e+005.7231221
GO:0045787positive regulation of cell cycle1.97e-021.00e+005.6561222
GO:0036464cytoplasmic ribonucleoprotein granule1.97e-021.00e+005.6561222
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription1.97e-021.00e+005.6561422
GO:0043025neuronal cell body1.98e-021.00e+003.17929245
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress2.05e-021.00e+005.5921123
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening2.23e-021.00e+005.4721325
GO:0035329hippo signaling2.32e-021.00e+005.4151526
GO:0051209release of sequestered calcium ion into cytosol2.32e-021.00e+005.4151126
GO:0000976transcription regulatory region sequence-specific DNA binding2.32e-021.00e+005.4151326
GO:0007017microtubule-based process2.41e-021.00e+005.3611227
GO:0071339MLL1 complex2.41e-021.00e+005.3611627
GO:0051258protein polymerization2.41e-021.00e+005.3611227
GO:0006954inflammatory response2.49e-021.00e+003.00226277
GO:0003727single-stranded RNA binding2.50e-021.00e+005.3081228
GO:0010494cytoplasmic stress granule2.67e-021.00e+005.2091230
GO:0071347cellular response to interleukin-12.76e-021.00e+005.1611231
GO:1903507negative regulation of nucleic acid-templated transcription2.85e-021.00e+005.1161232
GO:0031072heat shock protein binding2.94e-021.00e+005.0711233
GO:0030838positive regulation of actin filament polymerization3.02e-021.00e+005.0281134
GO:0019901protein kinase binding3.20e-021.00e+002.807218317
GO:0007257activation of JUN kinase activity3.20e-021.00e+004.9461536
GO:0051084'de novo' posttranslational protein folding3.29e-021.00e+004.9061537
GO:0035019somatic stem cell maintenance3.55e-021.00e+004.7941640
GO:0003723RNA binding3.68e-021.00e+002.698218342
GO:0031124mRNA 3'-end processing3.72e-021.00e+004.7231242
GO:0043565sequence-specific DNA binding3.76e-021.00e+002.681211346
GO:0006369termination of RNA polymerase II transcription3.98e-021.00e+004.6241245
GO:0043525positive regulation of neuron apoptotic process4.07e-021.00e+004.5921446
GO:0090263positive regulation of canonical Wnt signaling pathway4.24e-021.00e+004.5311348
GO:0006986response to unfolded protein4.42e-021.00e+004.4721450
GO:0030334regulation of cell migration4.42e-021.00e+004.4721550
GO:0034976response to endoplasmic reticulum stress4.50e-021.00e+004.4431251
GO:0045454cell redox homeostasis4.50e-021.00e+004.4431151
GO:0009611response to wounding4.59e-021.00e+004.4151552
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay4.68e-021.00e+004.3881453
GO:0000186activation of MAPKK activity4.76e-021.00e+004.3611254
GO:0006396RNA processing5.19e-021.00e+004.2331559
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity5.19e-021.00e+004.2331659
GO:0032481positive regulation of type I interferon production5.36e-021.00e+004.1851661
GO:0006406mRNA export from nucleus5.36e-021.00e+004.1851461
GO:0006987activation of signaling protein activity involved in unfolded protein response5.36e-021.00e+004.1851261
GO:0042060wound healing5.62e-021.00e+004.1161264
GO:0006310DNA recombination5.71e-021.00e+004.0931765
GO:0010468regulation of gene expression5.96e-021.00e+004.0281268
GO:0003729mRNA binding6.30e-021.00e+003.9461472
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity6.47e-021.00e+003.9061474
GO:0002020protease binding6.47e-021.00e+003.9061674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.56e-021.00e+003.8871175
GO:0044267cellular protein metabolic process6.62e-021.00e+002.227220474
GO:0035666TRIF-dependent toll-like receptor signaling pathway6.64e-021.00e+003.8681376
GO:0045893positive regulation of transcription, DNA-templated6.72e-021.00e+002.215224478
GO:0005929cilium6.72e-021.00e+003.8491277
GO:0071013catalytic step 2 spliceosome6.81e-021.00e+003.8301778
GO:0002756MyD88-independent toll-like receptor signaling pathway6.81e-021.00e+003.8301378
GO:0034138toll-like receptor 3 signaling pathway6.89e-021.00e+003.8121379
GO:0030968endoplasmic reticulum unfolded protein response6.89e-021.00e+003.8121279
GO:0071222cellular response to lipopolysaccharide7.06e-021.00e+003.7761481
GO:0009653anatomical structure morphogenesis7.23e-021.00e+003.7411283
GO:0050852T cell receptor signaling pathway7.40e-021.00e+003.7061285
GO:0003690double-stranded DNA binding7.48e-021.00e+003.6891386
GO:0090090negative regulation of canonical Wnt signaling pathway7.48e-021.00e+003.6891886
GO:0006979response to oxidative stress7.57e-021.00e+003.6731687
GO:0050821protein stabilization7.65e-021.00e+003.6561388
GO:0006629lipid metabolic process7.82e-021.00e+003.6241190
GO:0005200structural constituent of cytoskeleton7.90e-021.00e+003.6081691
GO:0001649osteoblast differentiation7.99e-021.00e+003.5921592
GO:0005770late endosome8.07e-021.00e+003.5761293
GO:0030529ribonucleoprotein complex9.64e-021.00e+003.30815112
GO:0045087innate immune response9.84e-021.00e+001.896215596
GO:0006325chromatin organization1.01e-011.00e+003.233112118
GO:0051092positive regulation of NF-kappaB transcription factor activity1.06e-011.00e+003.16115124
GO:0007050cell cycle arrest1.06e-011.00e+003.16115124
GO:0007179transforming growth factor beta receptor signaling pathway1.09e-011.00e+003.116111128
GO:0000086G2/M transition of mitotic cell cycle1.16e-011.00e+003.02814136
GO:0016055Wnt signaling pathway1.18e-011.00e+003.00714138
GO:0006457protein folding1.22e-011.00e+002.95617143
GO:0010628positive regulation of gene expression1.24e-011.00e+002.92617146
GO:0016607nuclear speck1.44e-011.00e+002.689112172
GO:0007049cell cycle1.46e-011.00e+002.67316174
GO:0005667transcription factor complex1.47e-011.00e+002.664117175
GO:0004672protein kinase activity1.48e-011.00e+002.64813177
GO:0031625ubiquitin protein ligase binding1.49e-011.00e+002.64015178
GO:0006367transcription initiation from RNA polymerase II promoter1.54e-011.00e+002.592122184
GO:0003924GTPase activity1.64e-011.00e+002.49417197
GO:0006184GTP catabolic process1.77e-011.00e+002.37417214
GO:0005730nucleolus1.77e-011.00e+001.0203661641
GO:0016071mRNA metabolic process1.83e-011.00e+002.31518223
GO:0016070RNA metabolic process2.01e-011.00e+002.16718247
GO:0005874microtubule2.03e-011.00e+002.15617249
GO:0005975carbohydrate metabolic process2.06e-011.00e+002.13318253
GO:0000166nucleotide binding2.10e-011.00e+002.099113259
GO:0006281DNA repair2.11e-011.00e+002.088114261
GO:0048011neurotrophin TRK receptor signaling pathway2.17e-011.00e+002.04417269
GO:0005739mitochondrion2.26e-011.00e+001.153223998
GO:0005856cytoskeleton2.33e-011.00e+001.93119291
GO:0035556intracellular signal transduction2.41e-011.00e+001.87219303
GO:0005525GTP binding2.46e-011.00e+001.840112310
GO:0003682chromatin binding2.58e-011.00e+001.762119327
GO:0008283cell proliferation2.59e-011.00e+001.758114328
GO:0046982protein heterodimerization activity2.93e-011.00e+001.54618380
GO:0000278mitotic cell cycle3.01e-011.00e+001.505115391
GO:0009986cell surface3.08e-011.00e+001.46519402
GO:0045892negative regulation of transcription, DNA-templated3.15e-011.00e+001.426124413
GO:0043066negative regulation of apoptotic process3.22e-011.00e+001.388116424
GO:0005524ATP binding3.29e-011.00e+000.7742311298
GO:0046872metal ion binding3.32e-011.00e+000.7642291307
GO:0006468protein phosphorylation3.44e-011.00e+001.270110460
GO:0042802identical protein binding3.58e-011.00e+001.197119484
GO:0006915apoptotic process4.00e-011.00e+000.999112555
GO:0042803protein homodimerization activity4.22e-011.00e+000.899119595
GO:0016020membrane4.58e-011.00e+000.4012461681
GO:0008270zinc ion binding6.06e-011.00e+000.154127997
GO:0016021integral component of membrane8.54e-011.00e+00-0.8371171982
GO:0070062extracellular vesicular exosome9.06e-011.00e+00-1.1131572400
GO:0005886plasma membrane9.23e-011.00e+00-1.2191492582