int-snw-5434

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.157	3.47e-19	5.85e-06	1.48e-04

chia-screen-data-Fav-int-snw-5434 subnetwork

Genes (12)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
LARS	51520	14	-2.574	3.157	105	Yes	Yes
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
MED19	219541	30	-2.657	3.449	115	Yes	-
APLP2	334	12	-2.732	3.206	35	Yes	Yes
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
MED28	80306	16	-2.404	3.216	80	Yes	-
[ POLR2E ]	5434	4	-2.037	3.157	115	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
MED12	9968	14	-2.465	3.206	65	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes

Interactions (15)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
POLR2E	5434	MED28	80306	pp	--	int.I2D: BioGrid
APLP2	334	MED12	9968	pp	--	int.I2D: MINT; int.Mint: MI:0407(direct interaction)
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
POLR2E	5434	MED12	9968	pp	--	int.I2D: BioGrid
PSMD2	5708	LARS	51520	pp	--	int.I2D: BioGrid_Yeast
MED28	80306	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HCFC1	3054	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
MED12	9968	MED28	80306	pp	--	int.I2D: BioGrid
MED12	9968	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
POLR2E	5434	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
YAP1	10413	MED28	80306	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
POLR2E	5434	LARS	51520	pp	--	int.I2D: YeastLow

Related GO terms (182)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016592	mediator complex	2.84e-06	4.09e-02	6.687	3	10	35
GO:0010467	gene expression	7.08e-06	1.02e-01	3.430	6	45	669
GO:0005654	nucleoplasm	7.43e-06	1.07e-01	2.959	7	64	1082
GO:0006366	transcription from RNA polymerase II promoter	1.35e-05	1.95e-01	3.842	5	30	419
GO:0001104	RNA polymerase II transcription cofactor activity	3.30e-04	1.00e+00	6.187	2	8	33
GO:0006367	transcription initiation from RNA polymerase II promoter	4.13e-04	1.00e+00	4.293	3	22	184
GO:0005515	protein binding	4.97e-04	1.00e+00	1.134	11	198	6024
GO:0019827	stem cell maintenance	6.72e-04	1.00e+00	5.677	2	7	47
GO:0008380	RNA splicing	7.72e-04	1.00e+00	3.983	3	22	228
GO:0060795	cell fate commitment involved in formation of primary germ layer	8.32e-04	1.00e+00	10.231	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	8.32e-04	1.00e+00	10.231	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	8.32e-04	1.00e+00	10.231	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	8.32e-04	1.00e+00	10.231	1	1	1
GO:0003713	transcription coactivator activity	8.64e-04	1.00e+00	3.927	3	24	237
GO:0006429	leucyl-tRNA aminoacylation	1.66e-03	1.00e+00	9.231	1	1	2
GO:0060242	contact inhibition	1.66e-03	1.00e+00	9.231	1	1	2
GO:0019046	release from viral latency	1.66e-03	1.00e+00	9.231	1	2	2
GO:0009786	regulation of asymmetric cell division	1.66e-03	1.00e+00	9.231	1	1	2
GO:0004823	leucine-tRNA ligase activity	1.66e-03	1.00e+00	9.231	1	1	2
GO:0046914	transition metal ion binding	2.49e-03	1.00e+00	8.646	1	1	3
GO:0060913	cardiac cell fate determination	2.49e-03	1.00e+00	8.646	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.49e-03	1.00e+00	8.646	1	1	3
GO:0090245	axis elongation involved in somitogenesis	2.49e-03	1.00e+00	8.646	1	1	3
GO:0005634	nucleus	2.54e-03	1.00e+00	1.247	9	159	4559
GO:0014044	Schwann cell development	3.32e-03	1.00e+00	8.231	1	1	4
GO:0051151	negative regulation of smooth muscle cell differentiation	3.32e-03	1.00e+00	8.231	1	1	4
GO:0070461	SAGA-type complex	4.15e-03	1.00e+00	7.909	1	2	5
GO:0001714	endodermal cell fate specification	4.15e-03	1.00e+00	7.909	1	1	5
GO:0007176	regulation of epidermal growth factor-activated receptor activity	4.15e-03	1.00e+00	7.909	1	1	5
GO:0002161	aminoacyl-tRNA editing activity	5.81e-03	1.00e+00	7.424	1	2	7
GO:0001055	RNA polymerase II activity	6.64e-03	1.00e+00	7.231	1	3	8
GO:0007617	mating behavior	6.64e-03	1.00e+00	7.231	1	1	8
GO:0070688	MLL5-L complex	6.64e-03	1.00e+00	7.231	1	1	8
GO:0043254	regulation of protein complex assembly	6.64e-03	1.00e+00	7.231	1	1	8
GO:0006355	regulation of transcription, DNA-templated	7.17e-03	1.00e+00	2.270	4	43	997
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	7.47e-03	1.00e+00	7.061	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	7.47e-03	1.00e+00	7.061	1	5	9
GO:0048188	Set1C/COMPASS complex	7.47e-03	1.00e+00	7.061	1	4	9
GO:0006450	regulation of translational fidelity	7.47e-03	1.00e+00	7.061	1	2	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	7.47e-03	1.00e+00	7.061	1	5	9
GO:0000398	mRNA splicing, via spliceosome	7.87e-03	1.00e+00	3.874	2	15	164
GO:0044212	transcription regulatory region DNA binding	8.24e-03	1.00e+00	3.839	2	17	168
GO:0035413	positive regulation of catenin import into nucleus	8.29e-03	1.00e+00	6.909	1	2	10
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	8.29e-03	1.00e+00	6.909	1	1	10
GO:0016020	membrane	8.36e-03	1.00e+00	1.838	5	46	1681
GO:0016607	nuclear speck	8.63e-03	1.00e+00	3.805	2	12	172
GO:0001054	RNA polymerase I activity	9.12e-03	1.00e+00	6.772	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	9.12e-03	1.00e+00	6.772	1	4	11
GO:0005736	DNA-directed RNA polymerase I complex	9.94e-03	1.00e+00	6.646	1	3	12
GO:0006878	cellular copper ion homeostasis	9.94e-03	1.00e+00	6.646	1	1	12
GO:0005838	proteasome regulatory particle	9.94e-03	1.00e+00	6.646	1	1	12
GO:0035198	miRNA binding	9.94e-03	1.00e+00	6.646	1	1	12
GO:0071480	cellular response to gamma radiation	1.08e-02	1.00e+00	6.531	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	1.08e-02	1.00e+00	6.531	1	2	13
GO:0030234	enzyme regulator activity	1.08e-02	1.00e+00	6.531	1	2	13
GO:0001967	suckling behavior	1.16e-02	1.00e+00	6.424	1	1	14
GO:0030518	intracellular steroid hormone receptor signaling pathway	1.16e-02	1.00e+00	6.424	1	6	14
GO:0005685	U1 snRNP	1.16e-02	1.00e+00	6.424	1	1	14
GO:0043981	histone H4-K5 acetylation	1.24e-02	1.00e+00	6.324	1	5	15
GO:0042809	vitamin D receptor binding	1.24e-02	1.00e+00	6.324	1	6	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	1.24e-02	1.00e+00	6.324	1	3	15
GO:0001824	blastocyst development	1.24e-02	1.00e+00	6.324	1	2	15
GO:0043982	histone H4-K8 acetylation	1.24e-02	1.00e+00	6.324	1	5	15
GO:0006376	mRNA splice site selection	1.24e-02	1.00e+00	6.324	1	1	15
GO:0043274	phospholipase binding	1.32e-02	1.00e+00	6.231	1	1	16
GO:0042176	regulation of protein catabolic process	1.32e-02	1.00e+00	6.231	1	2	16
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	1.32e-02	1.00e+00	6.231	1	2	16
GO:0005665	DNA-directed RNA polymerase II, core complex	1.32e-02	1.00e+00	6.231	1	4	16
GO:0001056	RNA polymerase III activity	1.32e-02	1.00e+00	6.231	1	3	16
GO:0005666	DNA-directed RNA polymerase III complex	1.41e-02	1.00e+00	6.144	1	3	17
GO:0022624	proteasome accessory complex	1.41e-02	1.00e+00	6.144	1	1	17
GO:0003677	DNA binding	1.44e-02	1.00e+00	1.981	4	49	1218
GO:0006386	termination of RNA polymerase III transcription	1.49e-02	1.00e+00	6.061	1	3	18
GO:0006385	transcription elongation from RNA polymerase III promoter	1.49e-02	1.00e+00	6.061	1	3	18
GO:0043984	histone H4-K16 acetylation	1.57e-02	1.00e+00	5.983	1	5	19
GO:0014003	oligodendrocyte development	1.65e-02	1.00e+00	5.909	1	5	20
GO:0043393	regulation of protein binding	1.65e-02	1.00e+00	5.909	1	1	20
GO:0000123	histone acetyltransferase complex	1.73e-02	1.00e+00	5.839	1	6	21
GO:0045787	positive regulation of cell cycle	1.82e-02	1.00e+00	5.772	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.82e-02	1.00e+00	5.772	1	4	22
GO:0030864	cortical actin cytoskeleton	1.90e-02	1.00e+00	5.708	1	1	23
GO:0003899	DNA-directed RNA polymerase activity	2.06e-02	1.00e+00	5.587	1	3	25
GO:0035329	hippo signaling	2.14e-02	1.00e+00	5.531	1	5	26
GO:0046966	thyroid hormone receptor binding	2.14e-02	1.00e+00	5.531	1	6	26
GO:0071339	MLL1 complex	2.22e-02	1.00e+00	5.476	1	6	27
GO:0030901	midbrain development	2.39e-02	1.00e+00	5.373	1	1	29
GO:0006360	transcription from RNA polymerase I promoter	2.47e-02	1.00e+00	5.324	1	3	30
GO:0006370	7-methylguanosine mRNA capping	2.47e-02	1.00e+00	5.324	1	5	30
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	2.48e-02	1.00e+00	2.192	3	41	789
GO:1903507	negative regulation of nucleic acid-templated transcription	2.63e-02	1.00e+00	5.231	1	2	32
GO:0030178	negative regulation of Wnt signaling pathway	2.87e-02	1.00e+00	5.102	1	4	35
GO:0003682	chromatin binding	2.91e-02	1.00e+00	2.878	2	19	327
GO:0006383	transcription from RNA polymerase III promoter	3.20e-02	1.00e+00	4.946	1	3	39
GO:0035019	somatic stem cell maintenance	3.28e-02	1.00e+00	4.909	1	6	40
GO:0050885	neuromuscular process controlling balance	3.28e-02	1.00e+00	4.909	1	2	40
GO:0030521	androgen receptor signaling pathway	3.36e-02	1.00e+00	4.874	1	5	41
GO:0006418	tRNA aminoacylation for protein translation	3.44e-02	1.00e+00	4.839	1	3	42
GO:0031124	mRNA 3'-end processing	3.44e-02	1.00e+00	4.839	1	2	42
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	3.52e-02	1.00e+00	4.805	1	7	43
GO:0050434	positive regulation of viral transcription	3.60e-02	1.00e+00	4.772	1	5	44
GO:0003712	transcription cofactor activity	3.60e-02	1.00e+00	4.772	1	8	44
GO:0006369	termination of RNA polymerase II transcription	3.68e-02	1.00e+00	4.739	1	2	45
GO:0006283	transcription-coupled nucleotide-excision repair	3.76e-02	1.00e+00	4.708	1	4	46
GO:0030900	forebrain development	4.00e-02	1.00e+00	4.616	1	1	49
GO:0006521	regulation of cellular amino acid metabolic process	4.08e-02	1.00e+00	4.587	1	1	50
GO:0005829	cytosol	4.20e-02	1.00e+00	1.268	5	86	2496
GO:0009611	response to wounding	4.24e-02	1.00e+00	4.531	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	4.32e-02	1.00e+00	4.503	1	5	53
GO:0008203	cholesterol metabolic process	4.64e-02	1.00e+00	4.398	1	2	57
GO:0000502	proteasome complex	4.72e-02	1.00e+00	4.373	1	3	58
GO:0008013	beta-catenin binding	4.88e-02	1.00e+00	4.324	1	9	60
GO:0032481	positive regulation of type I interferon production	4.96e-02	1.00e+00	4.300	1	6	61
GO:0006406	mRNA export from nucleus	4.96e-02	1.00e+00	4.300	1	4	61
GO:0004867	serine-type endopeptidase inhibitor activity	5.12e-02	1.00e+00	4.254	1	3	63
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	5.20e-02	1.00e+00	4.231	1	1	64
GO:0044822	poly(A) RNA binding	5.23e-02	1.00e+00	1.772	3	50	1056
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.28e-02	1.00e+00	4.209	1	2	65
GO:0006368	transcription elongation from RNA polymerase II promoter	5.44e-02	1.00e+00	4.165	1	6	67
GO:0006289	nucleotide-excision repair	5.52e-02	1.00e+00	4.144	1	5	68
GO:0010468	regulation of gene expression	5.52e-02	1.00e+00	4.144	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.67e-02	1.00e+00	4.102	1	2	70
GO:0007626	locomotory behavior	5.75e-02	1.00e+00	4.081	1	2	71
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.83e-02	1.00e+00	4.061	1	1	72
GO:0003729	mRNA binding	5.83e-02	1.00e+00	4.061	1	4	72
GO:0042802	identical protein binding	5.94e-02	1.00e+00	2.312	2	19	484
GO:0001843	neural tube closure	5.99e-02	1.00e+00	4.022	1	2	74
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.99e-02	1.00e+00	4.022	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.99e-02	1.00e+00	4.022	1	2	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	6.07e-02	1.00e+00	4.002	1	1	75
GO:0060070	canonical Wnt signaling pathway	6.07e-02	1.00e+00	4.002	1	4	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	6.38e-02	1.00e+00	3.927	1	2	79
GO:0009653	anatomical structure morphogenesis	6.69e-02	1.00e+00	3.856	1	2	83
GO:0016032	viral process	7.07e-02	1.00e+00	2.170	2	26	534
GO:0050821	protein stabilization	7.08e-02	1.00e+00	3.772	1	3	88
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	7.39e-02	1.00e+00	3.708	1	1	92
GO:0010951	negative regulation of endopeptidase activity	8.32e-02	1.00e+00	3.531	1	6	104
GO:0000209	protein polyubiquitination	9.24e-02	1.00e+00	3.373	1	3	116
GO:0006325	chromatin organization	9.39e-02	1.00e+00	3.348	1	12	118
GO:0008201	heparin binding	9.69e-02	1.00e+00	3.300	1	1	122
GO:0007507	heart development	1.10e-01	1.00e+00	3.112	1	7	139
GO:0003700	sequence-specific DNA binding transcription factor activity	1.12e-01	1.00e+00	1.782	2	39	699
GO:0010628	positive regulation of gene expression	1.15e-01	1.00e+00	3.041	1	7	146
GO:0000082	G1/S transition of mitotic cell cycle	1.17e-01	1.00e+00	3.012	1	3	149
GO:0042981	regulation of apoptotic process	1.18e-01	1.00e+00	3.002	1	4	150
GO:0006974	cellular response to DNA damage stimulus	1.19e-01	1.00e+00	2.993	1	7	151
GO:0008022	protein C-terminus binding	1.26e-01	1.00e+00	2.900	1	8	161
GO:0034641	cellular nitrogen compound metabolic process	1.33e-01	1.00e+00	2.813	1	2	171
GO:0005667	transcription factor complex	1.36e-01	1.00e+00	2.780	1	17	175
GO:0007049	cell cycle	1.36e-01	1.00e+00	2.788	1	6	174
GO:0031625	ubiquitin protein ligase binding	1.38e-01	1.00e+00	2.755	1	5	178
GO:0003714	transcription corepressor activity	1.38e-01	1.00e+00	2.755	1	11	178
GO:0019904	protein domain specific binding	1.39e-01	1.00e+00	2.747	1	8	179
GO:0004872	receptor activity	1.46e-01	1.00e+00	2.669	1	8	189
GO:0016071	mRNA metabolic process	1.71e-01	1.00e+00	2.430	1	8	223
GO:0005737	cytoplasm	1.81e-01	1.00e+00	0.674	5	124	3767
GO:0008134	transcription factor binding	1.84e-01	1.00e+00	2.312	1	18	242
GO:0043025	neuronal cell body	1.86e-01	1.00e+00	2.294	1	9	245
GO:0016070	RNA metabolic process	1.87e-01	1.00e+00	2.283	1	8	247
GO:0000166	nucleotide binding	1.95e-01	1.00e+00	2.214	1	13	259
GO:0006281	DNA repair	1.97e-01	1.00e+00	2.203	1	14	261
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.99e-01	1.00e+00	2.187	1	23	264
GO:0003779	actin binding	2.00e-01	1.00e+00	2.176	1	10	266
GO:0030198	extracellular matrix organization	2.12e-01	1.00e+00	2.086	1	6	283
GO:0007186	G-protein coupled receptor signaling pathway	2.16e-01	1.00e+00	2.056	1	1	289
GO:0008283	cell proliferation	2.41e-01	1.00e+00	1.874	1	14	328
GO:0003723	RNA binding	2.50e-01	1.00e+00	1.813	1	18	342
GO:0043565	sequence-specific DNA binding	2.53e-01	1.00e+00	1.796	1	11	346
GO:0005925	focal adhesion	2.65e-01	1.00e+00	1.715	1	9	366
GO:0000278	mitotic cell cycle	2.81e-01	1.00e+00	1.620	1	15	391
GO:0043066	negative regulation of apoptotic process	3.01e-01	1.00e+00	1.503	1	16	424
GO:0045893	positive regulation of transcription, DNA-templated	3.33e-01	1.00e+00	1.330	1	24	478
GO:0006915	apoptotic process	3.76e-01	1.00e+00	1.115	1	12	555
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.84e-01	1.00e+00	1.076	1	37	570
GO:0045087	innate immune response	3.97e-01	1.00e+00	1.012	1	15	596
GO:0005730	nucleolus	4.04e-01	1.00e+00	0.551	2	66	1641
GO:0005739	mitochondrion	5.77e-01	1.00e+00	0.268	1	23	998
GO:0070062	extracellular vesicular exosome	6.18e-01	1.00e+00	0.002	2	57	2400
GO:0044281	small molecule metabolic process	6.51e-01	1.00e+00	-0.011	1	20	1211
GO:0005886	plasma membrane	6.61e-01	1.00e+00	-0.103	2	49	2582
GO:0005524	ATP binding	6.78e-01	1.00e+00	-0.111	1	31	1298
GO:0006351	transcription, DNA-templated	7.19e-01	1.00e+00	-0.267	1	57	1446
GO:0016021	integral component of membrane	8.30e-01	1.00e+00	-0.722	1	17	1982

chia-Fav

int-snw-5434

Statistics

Genes (12)

Interactions (15)

Related GO terms (182)