int-snw-51429

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.870 6.99e-16 3.17e-04 2.51e-03
chia-screen-data-Fav-int-snw-51429 subnetwork

Genes (17)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
MED19 219541 30-2.6573.449115Yes-
PXN 5829 19-2.5543.193206YesYes
MED28 80306 16-2.4043.21680Yes-
MED13L 23389 12-2.5503.15921Yes-
YAP1 10413 94-4.2563.53853Yes-
POU5F1 5460 133-5.1483.538179YesYes
[ SNX9 ] 51429 1-1.7922.87025--
PSMD2 5708 47-4.1723.157386YesYes
TCP1 6950 10-2.3833.119241Yes-
ASAP1 50807 2-2.0722.87038Yes-
LUC7L3 51747 33-3.5233.44918Yes-
MED12 9968 14-2.4653.20665Yes-
MED24 9862 6-2.4823.03339Yes-
SRSF3 6428 73-2.9923.53854Yes-
MED14 9282 6-2.4203.13749Yes-
HNRNPU 3192 76-2.8693.538139Yes-
STK4 6789 3-2.0483.110228Yes-

Interactions (27)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
MED14 9282 MED12 9968 pp -- int.I2D: BioGrid
PXN 5829 SRSF3 6428 pp -- int.I2D: BIND
MED14 9282 MED28 80306 pp -- int.I2D: BioGrid
HNRNPU 3192 YAP1 10413 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo
SRSF3 6428 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
PSMD2 5708 TCP1 6950 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow
SNX9 51429 MED28 80306 pp -- int.I2D: MINT;
int.Mint: MI:0915(physical association)
STK4 6789 SNX9 51429 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
MED28 80306 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
ASAP1 50807 SNX9 51429 pp -- int.I2D: MINT;
int.Mint: MI:0407(direct interaction)
HNRNPU 3192 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
MED14 9282 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
HNRNPU 3192 STK4 6789 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
MED24 9862 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
MED24 9862 MED12 9968 pp -- int.I2D: BioGrid
PXN 5829 ASAP1 50807 pp -- int.I2D: BioGrid, HPRD, MINT;
int.Mint: MI:0915(physical association);
int.HPRD: in vitro
LUC7L3 51747 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
MED12 9968 MED28 80306 pp -- int.I2D: BioGrid
MED12 9968 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
MED13L 23389 MED28 80306 pp -- int.I2D: BioGrid
MED13L 23389 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
SRSF3 6428 STK4 6789 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
MED14 9282 MED24 9862 pp -- int.I2D: BioGrid
STK4 6789 TCP1 6950 pp -- int.I2D: BEHRENDS_AUTOPHAGY_LOW
YAP1 10413 MED28 80306 pp -- int.I2D: MINT;
int.Mint: MI:0915(physical association)
MED24 9862 MED28 80306 pp -- int.I2D: BioGrid

Related GO terms (226)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0016592mediator complex1.58e-122.28e-087.18461035
GO:0001104RNA polymerase II transcription cofactor activity2.77e-104.00e-067.0065833
GO:0019827stem cell maintenance2.28e-073.29e-036.1744747
GO:0030518intracellular steroid hormone receptor signaling pathway4.91e-077.08e-037.5063614
GO:0042809vitamin D receptor binding6.13e-078.85e-037.4073615
GO:0046966thyroid hormone receptor binding3.48e-065.02e-026.6133626
GO:0010467gene expression5.79e-068.35e-023.150745669
GO:0005654nucleoplasm1.29e-051.86e-012.6498641082
GO:0030521androgen receptor signaling pathway1.41e-052.03e-015.9563541
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity1.63e-052.35e-015.8873743
GO:0003712transcription cofactor activity1.75e-052.52e-015.8543844
GO:0006367transcription initiation from RNA polymerase II promoter5.36e-057.73e-014.205422184
GO:0006357regulation of transcription from RNA polymerase II promoter2.16e-041.00e+003.684423264
GO:0035329hippo signaling4.18e-041.00e+006.0282526
GO:0060795cell fate commitment involved in formation of primary germ layer1.18e-031.00e+009.729111
GO:0051435BH4 domain binding1.18e-031.00e+009.729111
GO:0090308regulation of methylation-dependent chromatin silencing1.18e-031.00e+009.729111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway1.18e-031.00e+009.729111
GO:0060965negative regulation of gene silencing by miRNA1.18e-031.00e+009.729111
GO:0006366transcription from RNA polymerase II promoter1.24e-031.00e+003.018430419
GO:0004872receptor activity1.32e-031.00e+003.75138189
GO:0008013beta-catenin binding2.22e-031.00e+004.8222960
GO:0008380RNA splicing2.25e-031.00e+003.481322228
GO:0060988lipid tube assembly2.36e-031.00e+008.729112
GO:0060242contact inhibition2.36e-031.00e+008.729112
GO:0009786regulation of asymmetric cell division2.36e-031.00e+008.729112
GO:0003713transcription coactivator activity2.51e-031.00e+003.425324237
GO:0003157endocardium development3.53e-031.00e+008.144113
GO:0060215primitive hemopoiesis3.53e-031.00e+008.144113
GO:0060913cardiac cell fate determination3.53e-031.00e+008.144113
GO:0003130BMP signaling pathway involved in heart induction3.53e-031.00e+008.144113
GO:0090245axis elongation involved in somitogenesis3.53e-031.00e+008.144113
GO:0005515protein binding3.97e-031.00e+000.873131986024
GO:0007021tubulin complex assembly4.71e-031.00e+007.729114
GO:0014044Schwann cell development4.71e-031.00e+007.729114
GO:0051151negative regulation of smooth muscle cell differentiation4.71e-031.00e+007.729114
GO:0001714endodermal cell fate specification5.88e-031.00e+007.407115
GO:0070934CRD-mediated mRNA stabilization5.88e-031.00e+007.407125
GO:0071933Arp2/3 complex binding5.88e-031.00e+007.407115
GO:0044822poly(A) RNA binding6.13e-031.00e+002.0065501056
GO:0036089cleavage furrow formation7.05e-031.00e+007.144126
GO:0060706cell differentiation involved in embryonic placenta development7.05e-031.00e+007.144116
GO:0070937CRD-mediated mRNA stability complex7.05e-031.00e+007.144136
GO:0007172signal complex assembly9.39e-031.00e+006.729118
GO:0060396growth hormone receptor signaling pathway9.39e-031.00e+006.729118
GO:0016020membrane9.85e-031.00e+001.5986461681
GO:0097284hepatocyte apoptotic process1.06e-021.00e+006.559119
GO:0005832chaperonin-containing T-complex1.06e-021.00e+006.559129
GO:0002199zona pellucida receptor complex1.17e-021.00e+006.4071210
GO:0035413positive regulation of catenin import into nucleus1.17e-021.00e+006.4071210
GO:0060071Wnt signaling pathway, planar cell polarity pathway1.17e-021.00e+006.4071110
GO:0097320membrane tubulation1.17e-021.00e+006.4071110
GO:0001841neural tube formation1.17e-021.00e+006.4071110
GO:0046621negative regulation of organ growth1.29e-021.00e+006.2691111
GO:0017166vinculin binding1.29e-021.00e+006.2691111
GO:0060391positive regulation of SMAD protein import into nucleus1.29e-021.00e+006.2691411
GO:0032461positive regulation of protein oligomerization1.41e-021.00e+006.1441112
GO:0005838proteasome regulatory particle1.41e-021.00e+006.1441112
GO:0035198miRNA binding1.41e-021.00e+006.1441112
GO:0071480cellular response to gamma radiation1.52e-021.00e+006.0281113
GO:0042789mRNA transcription from RNA polymerase II promoter1.52e-021.00e+006.0281213
GO:0030234enzyme regulator activity1.52e-021.00e+006.0281213
GO:0000398mRNA splicing, via spliceosome1.56e-021.00e+003.371215164
GO:0005685U1 snRNP1.64e-021.00e+005.9211114
GO:0034614cellular response to reactive oxygen species1.64e-021.00e+005.9211214
GO:0044212transcription regulatory region DNA binding1.64e-021.00e+003.336217168
GO:0000242pericentriolar material1.64e-021.00e+005.9211114
GO:0051044positive regulation of membrane protein ectodomain proteolysis1.64e-021.00e+005.9211114
GO:0043539protein serine/threonine kinase activator activity1.64e-021.00e+005.9211114
GO:0016607nuclear speck1.71e-021.00e+003.302212172
GO:0045893positive regulation of transcription, DNA-templated1.74e-021.00e+002.413324478
GO:0001824blastocyst development1.75e-021.00e+005.8221215
GO:0006376mRNA splice site selection1.75e-021.00e+005.8221115
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptors1.75e-021.00e+005.8221115
GO:0031625ubiquitin protein ligase binding1.82e-021.00e+003.25325178
GO:0043547positive regulation of GTPase activity1.86e-021.00e+003.23729180
GO:0005634nucleus1.86e-021.00e+000.896101594559
GO:0043274phospholipase binding1.87e-021.00e+005.7291116
GO:0042176regulation of protein catabolic process1.87e-021.00e+005.7291216
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription1.87e-021.00e+005.7291216
GO:00055451-phosphatidylinositol binding1.99e-021.00e+005.6411117
GO:0022624proteasome accessory complex1.99e-021.00e+005.6411117
GO:0014003oligodendrocyte development2.33e-021.00e+005.4071520
GO:0048041focal adhesion assembly2.45e-021.00e+005.3361121
GO:0032312regulation of ARF GTPase activity2.45e-021.00e+005.3361221
GO:0000281mitotic cytokinesis2.45e-021.00e+005.3361221
GO:0005720nuclear heterochromatin2.56e-021.00e+005.2691222
GO:0036464cytoplasmic ribonucleoprotein granule2.56e-021.00e+005.2691222
GO:0008060ARF GTPase activator activity2.56e-021.00e+005.2691222
GO:0030864cortical actin cytoskeleton2.68e-021.00e+005.2051123
GO:0016573histone acetylation2.68e-021.00e+005.2051223
GO:0031234extrinsic component of cytoplasmic side of plasma membrane2.79e-021.00e+005.1441124
GO:0007339binding of sperm to zona pellucida2.91e-021.00e+005.0851225
GO:0071902positive regulation of protein serine/threonine kinase activity3.02e-021.00e+005.0281226
GO:0048754branching morphogenesis of an epithelial tube3.14e-021.00e+004.9741127
GO:0008134transcription factor binding3.23e-021.00e+002.810218242
GO:0005875microtubule associated complex3.25e-021.00e+004.9211128
GO:0030032lamellipodium assembly3.37e-021.00e+004.8711129
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding3.37e-021.00e+004.8711229
GO:0001569patterning of blood vessels3.59e-021.00e+004.7741131
GO:1903507negative regulation of nucleic acid-templated transcription3.71e-021.00e+004.7291232
GO:0045600positive regulation of fat cell differentiation3.71e-021.00e+004.7291232
GO:0030178negative regulation of Wnt signaling pathway4.05e-021.00e+004.5991435
GO:0034446substrate adhesion-dependent cell spreading4.16e-021.00e+004.5591236
GO:0060271cilium morphogenesis4.28e-021.00e+004.5191337
GO:0051084'de novo' posttranslational protein folding4.28e-021.00e+004.5191537
GO:0032092positive regulation of protein binding4.39e-021.00e+004.4811238
GO:0005546phosphatidylinositol-4,5-bisphosphate binding4.50e-021.00e+004.4431239
GO:0035019somatic stem cell maintenance4.61e-021.00e+004.4071640
GO:0030136clathrin-coated vesicle4.84e-021.00e+004.3361542
GO:0031124mRNA 3'-end processing4.84e-021.00e+004.3361242
GO:0004402histone acetyltransferase activity4.95e-021.00e+004.3021643
GO:0006369termination of RNA polymerase II transcription5.18e-021.00e+004.2371245
GO:0045860positive regulation of protein kinase activity5.18e-021.00e+004.2371145
GO:0044297cell body5.29e-021.00e+004.2051246
GO:0030216keratinocyte differentiation5.40e-021.00e+004.1741247
GO:0000902cell morphogenesis5.62e-021.00e+004.1141449
GO:0001669acrosomal vesicle5.62e-021.00e+004.1141249
GO:0006521regulation of cellular amino acid metabolic process5.74e-021.00e+004.0851150
GO:0009611response to wounding5.96e-021.00e+004.0281552
GO:0003723RNA binding6.03e-021.00e+002.311218342
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding6.07e-021.00e+004.0011553
GO:0045944positive regulation of transcription from RNA polymerase II promoter6.25e-021.00e+001.690341789
GO:0001725stress fiber6.29e-021.00e+003.9471455
GO:0051291protein heterooligomerization6.40e-021.00e+003.9211456
GO:0016197endosomal transport6.51e-021.00e+003.8961257
GO:0000502proteasome complex6.62e-021.00e+003.8711358
GO:0006396RNA processing6.73e-021.00e+003.8461559
GO:0005925focal adhesion6.80e-021.00e+002.21329366
GO:0035091phosphatidylinositol binding6.96e-021.00e+003.7981161
GO:0006406mRNA export from nucleus6.96e-021.00e+003.7981461
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest7.29e-021.00e+003.7291164
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.40e-021.00e+003.7061265
GO:0010468regulation of gene expression7.72e-021.00e+003.6411268
GO:0034329cell junction assembly7.72e-021.00e+003.6411368
GO:0018105peptidyl-serine phosphorylation7.83e-021.00e+003.6201269
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.94e-021.00e+003.5991270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent8.16e-021.00e+003.5591172
GO:0003729mRNA binding8.16e-021.00e+003.5591472
GO:0001843neural tube closure8.38e-021.00e+003.5191274
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity8.38e-021.00e+003.5191474
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle8.38e-021.00e+003.5191274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I8.49e-021.00e+003.5001175
GO:0060070canonical Wnt signaling pathway8.49e-021.00e+003.5001475
GO:0071013catalytic step 2 spliceosome8.81e-021.00e+003.4431778
GO:0007229integrin-mediated signaling pathway8.81e-021.00e+003.4431378
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process8.92e-021.00e+003.4251279
GO:0001726ruffle9.03e-021.00e+003.4071480
GO:0009653anatomical structure morphogenesis9.35e-021.00e+003.3541283
GO:0006898receptor-mediated endocytosis9.46e-021.00e+003.3361384
GO:0090090negative regulation of canonical Wnt signaling pathway9.67e-021.00e+003.3021886
GO:0006936muscle contraction9.78e-021.00e+003.2861387
GO:0000187activation of MAPK activity1.01e-011.00e+003.2371390
GO:0007010cytoskeleton organization1.02e-011.00e+003.2211491
GO:0006928cellular component movement1.02e-011.00e+003.2211391
GO:0001649osteoblast differentiation1.03e-011.00e+003.2051592
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.03e-011.00e+003.2051192
GO:0051082unfolded protein binding1.04e-011.00e+003.1891793
GO:0007417central nervous system development1.07e-011.00e+003.1441596
GO:0005178integrin binding1.07e-011.00e+003.1441496
GO:0006355regulation of transcription, DNA-templated1.09e-011.00e+001.352343997
GO:0030659cytoplasmic vesicle membrane1.13e-011.00e+003.07012101
GO:0008360regulation of cell shape1.15e-011.00e+003.04214103
GO:0005938cell cortex1.16e-011.00e+003.02815104
GO:0016023cytoplasmic membrane-bounded vesicle1.17e-011.00e+003.01418105
GO:0006897endocytosis1.18e-011.00e+003.00117106
GO:0005802trans-Golgi network1.22e-011.00e+002.94711110
GO:0030529ribonucleoprotein complex1.24e-011.00e+002.92115112
GO:0000209protein polyubiquitination1.28e-011.00e+002.87113116
GO:0005737cytoplasm1.29e-011.00e+000.65771243767
GO:0046983protein dimerization activity1.30e-011.00e+002.84615118
GO:0030027lamellipodium1.38e-011.00e+002.76317125
GO:0006915apoptotic process1.38e-011.00e+001.612212555
GO:0007179transforming growth factor beta receptor signaling pathway1.41e-011.00e+002.729111128
GO:0018108peptidyl-tyrosine phosphorylation1.45e-011.00e+002.68414132
GO:0007507heart development1.52e-011.00e+002.61017139
GO:0042803protein homodimerization activity1.54e-011.00e+001.512219595
GO:0006457protein folding1.56e-011.00e+002.56917143
GO:0005829cytosol1.57e-011.00e+000.7655862496
GO:0000082G1/S transition of mitotic cell cycle1.62e-011.00e+002.50913149
GO:0042981regulation of apoptotic process1.63e-011.00e+002.50014150
GO:0006974cellular response to DNA damage stimulus1.64e-011.00e+002.49017151
GO:0003677DNA binding1.69e-011.00e+001.0633491218
GO:0046777protein autophosphorylation1.71e-011.00e+002.42514158
GO:0008022protein C-terminus binding1.74e-011.00e+002.39818161
GO:0000287magnesium ion binding1.77e-011.00e+002.37114164
GO:0005768endosome1.82e-011.00e+002.32813169
GO:0006886intracellular protein transport1.84e-011.00e+002.31114171
GO:0034641cellular nitrogen compound metabolic process1.84e-011.00e+002.31112171
GO:0005667transcription factor complex1.88e-011.00e+002.277117175
GO:0003714transcription corepressor activity1.90e-011.00e+002.253111178
GO:0019904protein domain specific binding1.91e-011.00e+002.24518179
GO:0005524ATP binding1.93e-011.00e+000.9723311298
GO:0007173epidermal growth factor receptor signaling pathway2.01e-011.00e+002.16615189
GO:0016071mRNA metabolic process2.33e-011.00e+001.92818223
GO:0007067mitotic nuclear division2.36e-011.00e+001.90216227
GO:0016070RNA metabolic process2.55e-011.00e+001.78018247
GO:0005874microtubule2.56e-011.00e+001.76917249
GO:0000166nucleotide binding2.65e-011.00e+001.712113259
GO:0003779actin binding2.71e-011.00e+001.673110266
GO:0043065positive regulation of apoptotic process2.73e-011.00e+001.66317268
GO:0007165signal transduction2.90e-011.00e+000.904213907
GO:0035556intracellular signal transduction3.03e-011.00e+001.48519303
GO:0004674protein serine/threonine kinase activity3.07e-011.00e+001.46216308
GO:0019901protein kinase binding3.15e-011.00e+001.420118317
GO:0005813centrosome3.22e-011.00e+001.38017326
GO:0003682chromatin binding3.23e-011.00e+001.375119327
GO:0008283cell proliferation3.24e-011.00e+001.371114328
GO:0008270zinc ion binding3.31e-011.00e+000.767227997
GO:0043565sequence-specific DNA binding3.38e-011.00e+001.294111346
GO:0008285negative regulation of cell proliferation3.44e-011.00e+001.265110353
GO:0007155cell adhesion3.57e-011.00e+001.20115369
GO:0000278mitotic cell cycle3.73e-011.00e+001.118115391
GO:0009986cell surface3.82e-011.00e+001.07819402
GO:0043066negative regulation of apoptotic process3.98e-011.00e+001.001116424
GO:0006468protein phosphorylation4.24e-011.00e+000.883110460
GO:0044267cellular protein metabolic process4.34e-011.00e+000.840120474
GO:0042802identical protein binding4.40e-011.00e+000.810119484
GO:0016032viral process4.74e-011.00e+000.668126534
GO:0005794Golgi apparatus5.21e-011.00e+000.47619610
GO:0070062extracellular vesicular exosome5.55e-011.00e+000.0853572400
GO:0003700sequence-specific DNA binding transcription factor activity5.70e-011.00e+000.279139699
GO:0005730nucleolus5.92e-011.00e+000.0482661641
GO:0005886plasma membrane6.09e-011.00e+00-0.0213492582
GO:0044281small molecule metabolic process7.75e-011.00e+00-0.5131201211
GO:0006351transcription, DNA-templated8.34e-011.00e+00-0.7691571446