Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
chia-screen-data-Fav | 2.870 | 6.99e-16 | 3.17e-04 | 2.51e-03 |
Gene Symbol | Entrez Gene ID | Frequency | chia-screen-data-Fav gene score | Best subnetwork score | Degree | Chia-Hits Primary | Chia-Hits Secondary |
---|---|---|---|---|---|---|---|
MED19 | 219541 | 30 | -2.657 | 3.449 | 115 | Yes | - |
PXN | 5829 | 19 | -2.554 | 3.193 | 206 | Yes | Yes |
MED28 | 80306 | 16 | -2.404 | 3.216 | 80 | Yes | - |
MED13L | 23389 | 12 | -2.550 | 3.159 | 21 | Yes | - |
YAP1 | 10413 | 94 | -4.256 | 3.538 | 53 | Yes | - |
POU5F1 | 5460 | 133 | -5.148 | 3.538 | 179 | Yes | Yes |
[ SNX9 ] | 51429 | 1 | -1.792 | 2.870 | 25 | - | - |
PSMD2 | 5708 | 47 | -4.172 | 3.157 | 386 | Yes | Yes |
TCP1 | 6950 | 10 | -2.383 | 3.119 | 241 | Yes | - |
ASAP1 | 50807 | 2 | -2.072 | 2.870 | 38 | Yes | - |
LUC7L3 | 51747 | 33 | -3.523 | 3.449 | 18 | Yes | - |
MED12 | 9968 | 14 | -2.465 | 3.206 | 65 | Yes | - |
MED24 | 9862 | 6 | -2.482 | 3.033 | 39 | Yes | - |
SRSF3 | 6428 | 73 | -2.992 | 3.538 | 54 | Yes | - |
MED14 | 9282 | 6 | -2.420 | 3.137 | 49 | Yes | - |
HNRNPU | 3192 | 76 | -2.869 | 3.538 | 139 | Yes | - |
STK4 | 6789 | 3 | -2.048 | 3.110 | 228 | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
MED14 | 9282 | MED12 | 9968 | pp | -- | int.I2D: BioGrid |
PXN | 5829 | SRSF3 | 6428 | pp | -- | int.I2D: BIND |
MED14 | 9282 | MED28 | 80306 | pp | -- | int.I2D: BioGrid |
HNRNPU | 3192 | YAP1 | 10413 | pp | -- | int.I2D: HPRD; int.HPRD: in vitro, in vivo |
SRSF3 | 6428 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
PSMD2 | 5708 | TCP1 | 6950 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow |
SNX9 | 51429 | MED28 | 80306 | pp | -- | int.I2D: MINT; int.Mint: MI:0915(physical association) |
STK4 | 6789 | SNX9 | 51429 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
MED28 | 80306 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
POU5F1 | 5460 | SRSF3 | 6428 | pp | -- | int.I2D: BioGrid |
ASAP1 | 50807 | SNX9 | 51429 | pp | -- | int.I2D: MINT; int.Mint: MI:0407(direct interaction) |
HNRNPU | 3192 | POU5F1 | 5460 | pp | -- | int.I2D: BioGrid_Mouse, IntAct_Mouse |
MED14 | 9282 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
HNRNPU | 3192 | STK4 | 6789 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
MED24 | 9862 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
MED24 | 9862 | MED12 | 9968 | pp | -- | int.I2D: BioGrid |
PXN | 5829 | ASAP1 | 50807 | pp | -- | int.I2D: BioGrid, HPRD, MINT; int.Mint: MI:0915(physical association); int.HPRD: in vitro |
LUC7L3 | 51747 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: IntAct |
MED12 | 9968 | MED28 | 80306 | pp | -- | int.I2D: BioGrid |
MED12 | 9968 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
MED13L | 23389 | MED28 | 80306 | pp | -- | int.I2D: BioGrid |
MED13L | 23389 | MED19 | 219541 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct |
SRSF3 | 6428 | STK4 | 6789 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
MED14 | 9282 | MED24 | 9862 | pp | -- | int.I2D: BioGrid |
STK4 | 6789 | TCP1 | 6950 | pp | -- | int.I2D: BEHRENDS_AUTOPHAGY_LOW |
YAP1 | 10413 | MED28 | 80306 | pp | -- | int.I2D: MINT; int.Mint: MI:0915(physical association) |
MED24 | 9862 | MED28 | 80306 | pp | -- | int.I2D: BioGrid |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0016592 | mediator complex | 1.58e-12 | 2.28e-08 | 7.184 | 6 | 10 | 35 |
GO:0001104 | RNA polymerase II transcription cofactor activity | 2.77e-10 | 4.00e-06 | 7.006 | 5 | 8 | 33 |
GO:0019827 | stem cell maintenance | 2.28e-07 | 3.29e-03 | 6.174 | 4 | 7 | 47 |
GO:0030518 | intracellular steroid hormone receptor signaling pathway | 4.91e-07 | 7.08e-03 | 7.506 | 3 | 6 | 14 |
GO:0042809 | vitamin D receptor binding | 6.13e-07 | 8.85e-03 | 7.407 | 3 | 6 | 15 |
GO:0046966 | thyroid hormone receptor binding | 3.48e-06 | 5.02e-02 | 6.613 | 3 | 6 | 26 |
GO:0010467 | gene expression | 5.79e-06 | 8.35e-02 | 3.150 | 7 | 45 | 669 |
GO:0005654 | nucleoplasm | 1.29e-05 | 1.86e-01 | 2.649 | 8 | 64 | 1082 |
GO:0030521 | androgen receptor signaling pathway | 1.41e-05 | 2.03e-01 | 5.956 | 3 | 5 | 41 |
GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity | 1.63e-05 | 2.35e-01 | 5.887 | 3 | 7 | 43 |
GO:0003712 | transcription cofactor activity | 1.75e-05 | 2.52e-01 | 5.854 | 3 | 8 | 44 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 5.36e-05 | 7.73e-01 | 4.205 | 4 | 22 | 184 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 2.16e-04 | 1.00e+00 | 3.684 | 4 | 23 | 264 |
GO:0035329 | hippo signaling | 4.18e-04 | 1.00e+00 | 6.028 | 2 | 5 | 26 |
GO:0060795 | cell fate commitment involved in formation of primary germ layer | 1.18e-03 | 1.00e+00 | 9.729 | 1 | 1 | 1 |
GO:0051435 | BH4 domain binding | 1.18e-03 | 1.00e+00 | 9.729 | 1 | 1 | 1 |
GO:0090308 | regulation of methylation-dependent chromatin silencing | 1.18e-03 | 1.00e+00 | 9.729 | 1 | 1 | 1 |
GO:0090081 | regulation of heart induction by regulation of canonical Wnt signaling pathway | 1.18e-03 | 1.00e+00 | 9.729 | 1 | 1 | 1 |
GO:0060965 | negative regulation of gene silencing by miRNA | 1.18e-03 | 1.00e+00 | 9.729 | 1 | 1 | 1 |
GO:0006366 | transcription from RNA polymerase II promoter | 1.24e-03 | 1.00e+00 | 3.018 | 4 | 30 | 419 |
GO:0004872 | receptor activity | 1.32e-03 | 1.00e+00 | 3.751 | 3 | 8 | 189 |
GO:0008013 | beta-catenin binding | 2.22e-03 | 1.00e+00 | 4.822 | 2 | 9 | 60 |
GO:0008380 | RNA splicing | 2.25e-03 | 1.00e+00 | 3.481 | 3 | 22 | 228 |
GO:0060988 | lipid tube assembly | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 1 | 2 |
GO:0060242 | contact inhibition | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 1 | 2 |
GO:0009786 | regulation of asymmetric cell division | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 1 | 2 |
GO:0003713 | transcription coactivator activity | 2.51e-03 | 1.00e+00 | 3.425 | 3 | 24 | 237 |
GO:0003157 | endocardium development | 3.53e-03 | 1.00e+00 | 8.144 | 1 | 1 | 3 |
GO:0060215 | primitive hemopoiesis | 3.53e-03 | 1.00e+00 | 8.144 | 1 | 1 | 3 |
GO:0060913 | cardiac cell fate determination | 3.53e-03 | 1.00e+00 | 8.144 | 1 | 1 | 3 |
GO:0003130 | BMP signaling pathway involved in heart induction | 3.53e-03 | 1.00e+00 | 8.144 | 1 | 1 | 3 |
GO:0090245 | axis elongation involved in somitogenesis | 3.53e-03 | 1.00e+00 | 8.144 | 1 | 1 | 3 |
GO:0005515 | protein binding | 3.97e-03 | 1.00e+00 | 0.873 | 13 | 198 | 6024 |
GO:0007021 | tubulin complex assembly | 4.71e-03 | 1.00e+00 | 7.729 | 1 | 1 | 4 |
GO:0014044 | Schwann cell development | 4.71e-03 | 1.00e+00 | 7.729 | 1 | 1 | 4 |
GO:0051151 | negative regulation of smooth muscle cell differentiation | 4.71e-03 | 1.00e+00 | 7.729 | 1 | 1 | 4 |
GO:0001714 | endodermal cell fate specification | 5.88e-03 | 1.00e+00 | 7.407 | 1 | 1 | 5 |
GO:0070934 | CRD-mediated mRNA stabilization | 5.88e-03 | 1.00e+00 | 7.407 | 1 | 2 | 5 |
GO:0071933 | Arp2/3 complex binding | 5.88e-03 | 1.00e+00 | 7.407 | 1 | 1 | 5 |
GO:0044822 | poly(A) RNA binding | 6.13e-03 | 1.00e+00 | 2.006 | 5 | 50 | 1056 |
GO:0036089 | cleavage furrow formation | 7.05e-03 | 1.00e+00 | 7.144 | 1 | 2 | 6 |
GO:0060706 | cell differentiation involved in embryonic placenta development | 7.05e-03 | 1.00e+00 | 7.144 | 1 | 1 | 6 |
GO:0070937 | CRD-mediated mRNA stability complex | 7.05e-03 | 1.00e+00 | 7.144 | 1 | 3 | 6 |
GO:0007172 | signal complex assembly | 9.39e-03 | 1.00e+00 | 6.729 | 1 | 1 | 8 |
GO:0060396 | growth hormone receptor signaling pathway | 9.39e-03 | 1.00e+00 | 6.729 | 1 | 1 | 8 |
GO:0016020 | membrane | 9.85e-03 | 1.00e+00 | 1.598 | 6 | 46 | 1681 |
GO:0097284 | hepatocyte apoptotic process | 1.06e-02 | 1.00e+00 | 6.559 | 1 | 1 | 9 |
GO:0005832 | chaperonin-containing T-complex | 1.06e-02 | 1.00e+00 | 6.559 | 1 | 2 | 9 |
GO:0002199 | zona pellucida receptor complex | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 2 | 10 |
GO:0035413 | positive regulation of catenin import into nucleus | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 2 | 10 |
GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 1 | 10 |
GO:0097320 | membrane tubulation | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 1 | 10 |
GO:0001841 | neural tube formation | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 1 | 10 |
GO:0046621 | negative regulation of organ growth | 1.29e-02 | 1.00e+00 | 6.269 | 1 | 1 | 11 |
GO:0017166 | vinculin binding | 1.29e-02 | 1.00e+00 | 6.269 | 1 | 1 | 11 |
GO:0060391 | positive regulation of SMAD protein import into nucleus | 1.29e-02 | 1.00e+00 | 6.269 | 1 | 4 | 11 |
GO:0032461 | positive regulation of protein oligomerization | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 1 | 12 |
GO:0005838 | proteasome regulatory particle | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 1 | 12 |
GO:0035198 | miRNA binding | 1.41e-02 | 1.00e+00 | 6.144 | 1 | 1 | 12 |
GO:0071480 | cellular response to gamma radiation | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 1 | 13 |
GO:0042789 | mRNA transcription from RNA polymerase II promoter | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 2 | 13 |
GO:0030234 | enzyme regulator activity | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 2 | 13 |
GO:0000398 | mRNA splicing, via spliceosome | 1.56e-02 | 1.00e+00 | 3.371 | 2 | 15 | 164 |
GO:0005685 | U1 snRNP | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 1 | 14 |
GO:0034614 | cellular response to reactive oxygen species | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 2 | 14 |
GO:0044212 | transcription regulatory region DNA binding | 1.64e-02 | 1.00e+00 | 3.336 | 2 | 17 | 168 |
GO:0000242 | pericentriolar material | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 1 | 14 |
GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 1 | 14 |
GO:0043539 | protein serine/threonine kinase activator activity | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 1 | 14 |
GO:0016607 | nuclear speck | 1.71e-02 | 1.00e+00 | 3.302 | 2 | 12 | 172 |
GO:0045893 | positive regulation of transcription, DNA-templated | 1.74e-02 | 1.00e+00 | 2.413 | 3 | 24 | 478 |
GO:0001824 | blastocyst development | 1.75e-02 | 1.00e+00 | 5.822 | 1 | 2 | 15 |
GO:0006376 | mRNA splice site selection | 1.75e-02 | 1.00e+00 | 5.822 | 1 | 1 | 15 |
GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | 1.75e-02 | 1.00e+00 | 5.822 | 1 | 1 | 15 |
GO:0031625 | ubiquitin protein ligase binding | 1.82e-02 | 1.00e+00 | 3.253 | 2 | 5 | 178 |
GO:0043547 | positive regulation of GTPase activity | 1.86e-02 | 1.00e+00 | 3.237 | 2 | 9 | 180 |
GO:0005634 | nucleus | 1.86e-02 | 1.00e+00 | 0.896 | 10 | 159 | 4559 |
GO:0043274 | phospholipase binding | 1.87e-02 | 1.00e+00 | 5.729 | 1 | 1 | 16 |
GO:0042176 | regulation of protein catabolic process | 1.87e-02 | 1.00e+00 | 5.729 | 1 | 2 | 16 |
GO:0001190 | RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription | 1.87e-02 | 1.00e+00 | 5.729 | 1 | 2 | 16 |
GO:0005545 | 1-phosphatidylinositol binding | 1.99e-02 | 1.00e+00 | 5.641 | 1 | 1 | 17 |
GO:0022624 | proteasome accessory complex | 1.99e-02 | 1.00e+00 | 5.641 | 1 | 1 | 17 |
GO:0014003 | oligodendrocyte development | 2.33e-02 | 1.00e+00 | 5.407 | 1 | 5 | 20 |
GO:0048041 | focal adhesion assembly | 2.45e-02 | 1.00e+00 | 5.336 | 1 | 1 | 21 |
GO:0032312 | regulation of ARF GTPase activity | 2.45e-02 | 1.00e+00 | 5.336 | 1 | 2 | 21 |
GO:0000281 | mitotic cytokinesis | 2.45e-02 | 1.00e+00 | 5.336 | 1 | 2 | 21 |
GO:0005720 | nuclear heterochromatin | 2.56e-02 | 1.00e+00 | 5.269 | 1 | 2 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 2.56e-02 | 1.00e+00 | 5.269 | 1 | 2 | 22 |
GO:0008060 | ARF GTPase activator activity | 2.56e-02 | 1.00e+00 | 5.269 | 1 | 2 | 22 |
GO:0030864 | cortical actin cytoskeleton | 2.68e-02 | 1.00e+00 | 5.205 | 1 | 1 | 23 |
GO:0016573 | histone acetylation | 2.68e-02 | 1.00e+00 | 5.205 | 1 | 2 | 23 |
GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane | 2.79e-02 | 1.00e+00 | 5.144 | 1 | 1 | 24 |
GO:0007339 | binding of sperm to zona pellucida | 2.91e-02 | 1.00e+00 | 5.085 | 1 | 2 | 25 |
GO:0071902 | positive regulation of protein serine/threonine kinase activity | 3.02e-02 | 1.00e+00 | 5.028 | 1 | 2 | 26 |
GO:0048754 | branching morphogenesis of an epithelial tube | 3.14e-02 | 1.00e+00 | 4.974 | 1 | 1 | 27 |
GO:0008134 | transcription factor binding | 3.23e-02 | 1.00e+00 | 2.810 | 2 | 18 | 242 |
GO:0005875 | microtubule associated complex | 3.25e-02 | 1.00e+00 | 4.921 | 1 | 1 | 28 |
GO:0030032 | lamellipodium assembly | 3.37e-02 | 1.00e+00 | 4.871 | 1 | 1 | 29 |
GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | 3.37e-02 | 1.00e+00 | 4.871 | 1 | 2 | 29 |
GO:0001569 | patterning of blood vessels | 3.59e-02 | 1.00e+00 | 4.774 | 1 | 1 | 31 |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 3.71e-02 | 1.00e+00 | 4.729 | 1 | 2 | 32 |
GO:0045600 | positive regulation of fat cell differentiation | 3.71e-02 | 1.00e+00 | 4.729 | 1 | 2 | 32 |
GO:0030178 | negative regulation of Wnt signaling pathway | 4.05e-02 | 1.00e+00 | 4.599 | 1 | 4 | 35 |
GO:0034446 | substrate adhesion-dependent cell spreading | 4.16e-02 | 1.00e+00 | 4.559 | 1 | 2 | 36 |
GO:0060271 | cilium morphogenesis | 4.28e-02 | 1.00e+00 | 4.519 | 1 | 3 | 37 |
GO:0051084 | 'de novo' posttranslational protein folding | 4.28e-02 | 1.00e+00 | 4.519 | 1 | 5 | 37 |
GO:0032092 | positive regulation of protein binding | 4.39e-02 | 1.00e+00 | 4.481 | 1 | 2 | 38 |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 4.50e-02 | 1.00e+00 | 4.443 | 1 | 2 | 39 |
GO:0035019 | somatic stem cell maintenance | 4.61e-02 | 1.00e+00 | 4.407 | 1 | 6 | 40 |
GO:0030136 | clathrin-coated vesicle | 4.84e-02 | 1.00e+00 | 4.336 | 1 | 5 | 42 |
GO:0031124 | mRNA 3'-end processing | 4.84e-02 | 1.00e+00 | 4.336 | 1 | 2 | 42 |
GO:0004402 | histone acetyltransferase activity | 4.95e-02 | 1.00e+00 | 4.302 | 1 | 6 | 43 |
GO:0006369 | termination of RNA polymerase II transcription | 5.18e-02 | 1.00e+00 | 4.237 | 1 | 2 | 45 |
GO:0045860 | positive regulation of protein kinase activity | 5.18e-02 | 1.00e+00 | 4.237 | 1 | 1 | 45 |
GO:0044297 | cell body | 5.29e-02 | 1.00e+00 | 4.205 | 1 | 2 | 46 |
GO:0030216 | keratinocyte differentiation | 5.40e-02 | 1.00e+00 | 4.174 | 1 | 2 | 47 |
GO:0000902 | cell morphogenesis | 5.62e-02 | 1.00e+00 | 4.114 | 1 | 4 | 49 |
GO:0001669 | acrosomal vesicle | 5.62e-02 | 1.00e+00 | 4.114 | 1 | 2 | 49 |
GO:0006521 | regulation of cellular amino acid metabolic process | 5.74e-02 | 1.00e+00 | 4.085 | 1 | 1 | 50 |
GO:0009611 | response to wounding | 5.96e-02 | 1.00e+00 | 4.028 | 1 | 5 | 52 |
GO:0003723 | RNA binding | 6.03e-02 | 1.00e+00 | 2.311 | 2 | 18 | 342 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 6.07e-02 | 1.00e+00 | 4.001 | 1 | 5 | 53 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 6.25e-02 | 1.00e+00 | 1.690 | 3 | 41 | 789 |
GO:0001725 | stress fiber | 6.29e-02 | 1.00e+00 | 3.947 | 1 | 4 | 55 |
GO:0051291 | protein heterooligomerization | 6.40e-02 | 1.00e+00 | 3.921 | 1 | 4 | 56 |
GO:0016197 | endosomal transport | 6.51e-02 | 1.00e+00 | 3.896 | 1 | 2 | 57 |
GO:0000502 | proteasome complex | 6.62e-02 | 1.00e+00 | 3.871 | 1 | 3 | 58 |
GO:0006396 | RNA processing | 6.73e-02 | 1.00e+00 | 3.846 | 1 | 5 | 59 |
GO:0005925 | focal adhesion | 6.80e-02 | 1.00e+00 | 2.213 | 2 | 9 | 366 |
GO:0035091 | phosphatidylinositol binding | 6.96e-02 | 1.00e+00 | 3.798 | 1 | 1 | 61 |
GO:0006406 | mRNA export from nucleus | 6.96e-02 | 1.00e+00 | 3.798 | 1 | 4 | 61 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 7.29e-02 | 1.00e+00 | 3.729 | 1 | 1 | 64 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 7.40e-02 | 1.00e+00 | 3.706 | 1 | 2 | 65 |
GO:0010468 | regulation of gene expression | 7.72e-02 | 1.00e+00 | 3.641 | 1 | 2 | 68 |
GO:0034329 | cell junction assembly | 7.72e-02 | 1.00e+00 | 3.641 | 1 | 3 | 68 |
GO:0018105 | peptidyl-serine phosphorylation | 7.83e-02 | 1.00e+00 | 3.620 | 1 | 2 | 69 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 7.94e-02 | 1.00e+00 | 3.599 | 1 | 2 | 70 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 8.16e-02 | 1.00e+00 | 3.559 | 1 | 1 | 72 |
GO:0003729 | mRNA binding | 8.16e-02 | 1.00e+00 | 3.559 | 1 | 4 | 72 |
GO:0001843 | neural tube closure | 8.38e-02 | 1.00e+00 | 3.519 | 1 | 2 | 74 |
GO:0000981 | sequence-specific DNA binding RNA polymerase II transcription factor activity | 8.38e-02 | 1.00e+00 | 3.519 | 1 | 4 | 74 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 8.38e-02 | 1.00e+00 | 3.519 | 1 | 2 | 74 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 8.49e-02 | 1.00e+00 | 3.500 | 1 | 1 | 75 |
GO:0060070 | canonical Wnt signaling pathway | 8.49e-02 | 1.00e+00 | 3.500 | 1 | 4 | 75 |
GO:0071013 | catalytic step 2 spliceosome | 8.81e-02 | 1.00e+00 | 3.443 | 1 | 7 | 78 |
GO:0007229 | integrin-mediated signaling pathway | 8.81e-02 | 1.00e+00 | 3.443 | 1 | 3 | 78 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 8.92e-02 | 1.00e+00 | 3.425 | 1 | 2 | 79 |
GO:0001726 | ruffle | 9.03e-02 | 1.00e+00 | 3.407 | 1 | 4 | 80 |
GO:0009653 | anatomical structure morphogenesis | 9.35e-02 | 1.00e+00 | 3.354 | 1 | 2 | 83 |
GO:0006898 | receptor-mediated endocytosis | 9.46e-02 | 1.00e+00 | 3.336 | 1 | 3 | 84 |
GO:0090090 | negative regulation of canonical Wnt signaling pathway | 9.67e-02 | 1.00e+00 | 3.302 | 1 | 8 | 86 |
GO:0006936 | muscle contraction | 9.78e-02 | 1.00e+00 | 3.286 | 1 | 3 | 87 |
GO:0000187 | activation of MAPK activity | 1.01e-01 | 1.00e+00 | 3.237 | 1 | 3 | 90 |
GO:0007010 | cytoskeleton organization | 1.02e-01 | 1.00e+00 | 3.221 | 1 | 4 | 91 |
GO:0006928 | cellular component movement | 1.02e-01 | 1.00e+00 | 3.221 | 1 | 3 | 91 |
GO:0001649 | osteoblast differentiation | 1.03e-01 | 1.00e+00 | 3.205 | 1 | 5 | 92 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 1.03e-01 | 1.00e+00 | 3.205 | 1 | 1 | 92 |
GO:0051082 | unfolded protein binding | 1.04e-01 | 1.00e+00 | 3.189 | 1 | 7 | 93 |
GO:0007417 | central nervous system development | 1.07e-01 | 1.00e+00 | 3.144 | 1 | 5 | 96 |
GO:0005178 | integrin binding | 1.07e-01 | 1.00e+00 | 3.144 | 1 | 4 | 96 |
GO:0006355 | regulation of transcription, DNA-templated | 1.09e-01 | 1.00e+00 | 1.352 | 3 | 43 | 997 |
GO:0030659 | cytoplasmic vesicle membrane | 1.13e-01 | 1.00e+00 | 3.070 | 1 | 2 | 101 |
GO:0008360 | regulation of cell shape | 1.15e-01 | 1.00e+00 | 3.042 | 1 | 4 | 103 |
GO:0005938 | cell cortex | 1.16e-01 | 1.00e+00 | 3.028 | 1 | 5 | 104 |
GO:0016023 | cytoplasmic membrane-bounded vesicle | 1.17e-01 | 1.00e+00 | 3.014 | 1 | 8 | 105 |
GO:0006897 | endocytosis | 1.18e-01 | 1.00e+00 | 3.001 | 1 | 7 | 106 |
GO:0005802 | trans-Golgi network | 1.22e-01 | 1.00e+00 | 2.947 | 1 | 1 | 110 |
GO:0030529 | ribonucleoprotein complex | 1.24e-01 | 1.00e+00 | 2.921 | 1 | 5 | 112 |
GO:0000209 | protein polyubiquitination | 1.28e-01 | 1.00e+00 | 2.871 | 1 | 3 | 116 |
GO:0005737 | cytoplasm | 1.29e-01 | 1.00e+00 | 0.657 | 7 | 124 | 3767 |
GO:0046983 | protein dimerization activity | 1.30e-01 | 1.00e+00 | 2.846 | 1 | 5 | 118 |
GO:0030027 | lamellipodium | 1.38e-01 | 1.00e+00 | 2.763 | 1 | 7 | 125 |
GO:0006915 | apoptotic process | 1.38e-01 | 1.00e+00 | 1.612 | 2 | 12 | 555 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 1.41e-01 | 1.00e+00 | 2.729 | 1 | 11 | 128 |
GO:0018108 | peptidyl-tyrosine phosphorylation | 1.45e-01 | 1.00e+00 | 2.684 | 1 | 4 | 132 |
GO:0007507 | heart development | 1.52e-01 | 1.00e+00 | 2.610 | 1 | 7 | 139 |
GO:0042803 | protein homodimerization activity | 1.54e-01 | 1.00e+00 | 1.512 | 2 | 19 | 595 |
GO:0006457 | protein folding | 1.56e-01 | 1.00e+00 | 2.569 | 1 | 7 | 143 |
GO:0005829 | cytosol | 1.57e-01 | 1.00e+00 | 0.765 | 5 | 86 | 2496 |
GO:0000082 | G1/S transition of mitotic cell cycle | 1.62e-01 | 1.00e+00 | 2.509 | 1 | 3 | 149 |
GO:0042981 | regulation of apoptotic process | 1.63e-01 | 1.00e+00 | 2.500 | 1 | 4 | 150 |
GO:0006974 | cellular response to DNA damage stimulus | 1.64e-01 | 1.00e+00 | 2.490 | 1 | 7 | 151 |
GO:0003677 | DNA binding | 1.69e-01 | 1.00e+00 | 1.063 | 3 | 49 | 1218 |
GO:0046777 | protein autophosphorylation | 1.71e-01 | 1.00e+00 | 2.425 | 1 | 4 | 158 |
GO:0008022 | protein C-terminus binding | 1.74e-01 | 1.00e+00 | 2.398 | 1 | 8 | 161 |
GO:0000287 | magnesium ion binding | 1.77e-01 | 1.00e+00 | 2.371 | 1 | 4 | 164 |
GO:0005768 | endosome | 1.82e-01 | 1.00e+00 | 2.328 | 1 | 3 | 169 |
GO:0006886 | intracellular protein transport | 1.84e-01 | 1.00e+00 | 2.311 | 1 | 4 | 171 |
GO:0034641 | cellular nitrogen compound metabolic process | 1.84e-01 | 1.00e+00 | 2.311 | 1 | 2 | 171 |
GO:0005667 | transcription factor complex | 1.88e-01 | 1.00e+00 | 2.277 | 1 | 17 | 175 |
GO:0003714 | transcription corepressor activity | 1.90e-01 | 1.00e+00 | 2.253 | 1 | 11 | 178 |
GO:0019904 | protein domain specific binding | 1.91e-01 | 1.00e+00 | 2.245 | 1 | 8 | 179 |
GO:0005524 | ATP binding | 1.93e-01 | 1.00e+00 | 0.972 | 3 | 31 | 1298 |
GO:0007173 | epidermal growth factor receptor signaling pathway | 2.01e-01 | 1.00e+00 | 2.166 | 1 | 5 | 189 |
GO:0016071 | mRNA metabolic process | 2.33e-01 | 1.00e+00 | 1.928 | 1 | 8 | 223 |
GO:0007067 | mitotic nuclear division | 2.36e-01 | 1.00e+00 | 1.902 | 1 | 6 | 227 |
GO:0016070 | RNA metabolic process | 2.55e-01 | 1.00e+00 | 1.780 | 1 | 8 | 247 |
GO:0005874 | microtubule | 2.56e-01 | 1.00e+00 | 1.769 | 1 | 7 | 249 |
GO:0000166 | nucleotide binding | 2.65e-01 | 1.00e+00 | 1.712 | 1 | 13 | 259 |
GO:0003779 | actin binding | 2.71e-01 | 1.00e+00 | 1.673 | 1 | 10 | 266 |
GO:0043065 | positive regulation of apoptotic process | 2.73e-01 | 1.00e+00 | 1.663 | 1 | 7 | 268 |
GO:0007165 | signal transduction | 2.90e-01 | 1.00e+00 | 0.904 | 2 | 13 | 907 |
GO:0035556 | intracellular signal transduction | 3.03e-01 | 1.00e+00 | 1.485 | 1 | 9 | 303 |
GO:0004674 | protein serine/threonine kinase activity | 3.07e-01 | 1.00e+00 | 1.462 | 1 | 6 | 308 |
GO:0019901 | protein kinase binding | 3.15e-01 | 1.00e+00 | 1.420 | 1 | 18 | 317 |
GO:0005813 | centrosome | 3.22e-01 | 1.00e+00 | 1.380 | 1 | 7 | 326 |
GO:0003682 | chromatin binding | 3.23e-01 | 1.00e+00 | 1.375 | 1 | 19 | 327 |
GO:0008283 | cell proliferation | 3.24e-01 | 1.00e+00 | 1.371 | 1 | 14 | 328 |
GO:0008270 | zinc ion binding | 3.31e-01 | 1.00e+00 | 0.767 | 2 | 27 | 997 |
GO:0043565 | sequence-specific DNA binding | 3.38e-01 | 1.00e+00 | 1.294 | 1 | 11 | 346 |
GO:0008285 | negative regulation of cell proliferation | 3.44e-01 | 1.00e+00 | 1.265 | 1 | 10 | 353 |
GO:0007155 | cell adhesion | 3.57e-01 | 1.00e+00 | 1.201 | 1 | 5 | 369 |
GO:0000278 | mitotic cell cycle | 3.73e-01 | 1.00e+00 | 1.118 | 1 | 15 | 391 |
GO:0009986 | cell surface | 3.82e-01 | 1.00e+00 | 1.078 | 1 | 9 | 402 |
GO:0043066 | negative regulation of apoptotic process | 3.98e-01 | 1.00e+00 | 1.001 | 1 | 16 | 424 |
GO:0006468 | protein phosphorylation | 4.24e-01 | 1.00e+00 | 0.883 | 1 | 10 | 460 |
GO:0044267 | cellular protein metabolic process | 4.34e-01 | 1.00e+00 | 0.840 | 1 | 20 | 474 |
GO:0042802 | identical protein binding | 4.40e-01 | 1.00e+00 | 0.810 | 1 | 19 | 484 |
GO:0016032 | viral process | 4.74e-01 | 1.00e+00 | 0.668 | 1 | 26 | 534 |
GO:0005794 | Golgi apparatus | 5.21e-01 | 1.00e+00 | 0.476 | 1 | 9 | 610 |
GO:0070062 | extracellular vesicular exosome | 5.55e-01 | 1.00e+00 | 0.085 | 3 | 57 | 2400 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 5.70e-01 | 1.00e+00 | 0.279 | 1 | 39 | 699 |
GO:0005730 | nucleolus | 5.92e-01 | 1.00e+00 | 0.048 | 2 | 66 | 1641 |
GO:0005886 | plasma membrane | 6.09e-01 | 1.00e+00 | -0.021 | 3 | 49 | 2582 |
GO:0044281 | small molecule metabolic process | 7.75e-01 | 1.00e+00 | -0.513 | 1 | 20 | 1211 |
GO:0006351 | transcription, DNA-templated | 8.34e-01 | 1.00e+00 | -0.769 | 1 | 57 | 1446 |