int-snw-5033

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.877	5.78e-16	2.89e-04	2.35e-03

chia-screen-data-Fav-int-snw-5033 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
EXOC3	11336	1	-1.576	2.877	21	-	-
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
TPR	7175	18	-2.638	3.072	28	Yes	Yes
ATG2A	23130	1	-1.276	2.877	310	-	-
[ P4HA1 ]	5033	1	-0.670	2.877	11	-	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-

Interactions (10)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
P4HA1	5033	ATG2A	23130	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
P4HA1	5033	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
TPR	7175	EXOC3	11336	pp	--	int.I2D: BioGrid_Fly
P4HA1	5033	EXOC3	11336	pp	--	int.I2D: BioGrid_Fly, BIND_Fly, FlyEmbryo
PSMD2	5708	ATG2A	23130	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (197)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	3.31e-06	4.77e-02	3.085	7	64	1082
GO:0005515	protein binding	6.71e-05	9.68e-01	1.260	11	198	6024
GO:0006366	transcription from RNA polymerase II promoter	1.97e-04	1.00e+00	3.646	4	30	419
GO:0019898	extrinsic component of membrane	4.48e-04	1.00e+00	5.964	2	2	42
GO:0060795	cell fate commitment involved in formation of primary germ layer	7.63e-04	1.00e+00	10.357	1	1	1
GO:1901673	regulation of spindle assembly involved in mitosis	7.63e-04	1.00e+00	10.357	1	1	1
GO:0043578	nuclear matrix organization	7.63e-04	1.00e+00	10.357	1	1	1
GO:0010965	regulation of mitotic sister chromatid separation	7.63e-04	1.00e+00	10.357	1	1	1
GO:0006404	RNA import into nucleus	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	7.63e-04	1.00e+00	10.357	1	1	1
GO:0031453	positive regulation of heterochromatin assembly	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	7.63e-04	1.00e+00	10.357	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	7.63e-04	1.00e+00	10.357	1	1	1
GO:0010467	gene expression	1.17e-03	1.00e+00	2.971	4	45	669
GO:0000189	MAPK import into nucleus	1.52e-03	1.00e+00	9.357	1	1	2
GO:0060242	contact inhibition	1.52e-03	1.00e+00	9.357	1	1	2
GO:0031990	mRNA export from nucleus in response to heat stress	1.52e-03	1.00e+00	9.357	1	2	2
GO:0019046	release from viral latency	1.52e-03	1.00e+00	9.357	1	2	2
GO:0009786	regulation of asymmetric cell division	1.52e-03	1.00e+00	9.357	1	1	2
GO:0070840	dynein complex binding	1.52e-03	1.00e+00	9.357	1	1	2
GO:0046832	negative regulation of RNA export from nucleus	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006405	RNA export from nucleus	2.29e-03	1.00e+00	8.772	1	2	3
GO:0016222	procollagen-proline 4-dioxygenase complex	2.29e-03	1.00e+00	8.772	1	1	3
GO:0042306	regulation of protein import into nucleus	2.29e-03	1.00e+00	8.772	1	2	3
GO:0060913	cardiac cell fate determination	2.29e-03	1.00e+00	8.772	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.29e-03	1.00e+00	8.772	1	1	3
GO:0004656	procollagen-proline 4-dioxygenase activity	3.05e-03	1.00e+00	8.357	1	1	4
GO:0044804	nucleophagy	3.05e-03	1.00e+00	8.357	1	1	4
GO:0006999	nuclear pore organization	3.05e-03	1.00e+00	8.357	1	1	4
GO:0044615	nuclear pore nuclear basket	3.05e-03	1.00e+00	8.357	1	1	4
GO:0006995	cellular response to nitrogen starvation	3.05e-03	1.00e+00	8.357	1	1	4
GO:0070461	SAGA-type complex	3.81e-03	1.00e+00	8.035	1	2	5
GO:0001714	endodermal cell fate specification	3.81e-03	1.00e+00	8.035	1	1	5
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	3.81e-03	1.00e+00	8.035	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.81e-03	1.00e+00	8.035	1	2	5
GO:0010793	regulation of mRNA export from nucleus	3.81e-03	1.00e+00	8.035	1	1	5
GO:0070849	response to epidermal growth factor	3.81e-03	1.00e+00	8.035	1	1	5
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4.57e-03	1.00e+00	7.772	1	1	6
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	4.57e-03	1.00e+00	7.772	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	4.57e-03	1.00e+00	7.772	1	3	6
GO:0006355	regulation of transcription, DNA-templated	5.05e-03	1.00e+00	2.395	4	43	997
GO:0046825	regulation of protein export from nucleus	5.33e-03	1.00e+00	7.549	1	2	7
GO:0051292	nuclear pore complex assembly	6.09e-03	1.00e+00	7.357	1	4	8
GO:0070688	MLL5-L complex	6.09e-03	1.00e+00	7.357	1	1	8
GO:0043254	regulation of protein complex assembly	6.09e-03	1.00e+00	7.357	1	1	8
GO:0035457	cellular response to interferon-alpha	6.09e-03	1.00e+00	7.357	1	1	8
GO:0044822	poly(A) RNA binding	6.21e-03	1.00e+00	2.312	4	50	1056
GO:0000398	mRNA splicing, via spliceosome	6.61e-03	1.00e+00	3.999	2	15	164
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	6.85e-03	1.00e+00	7.187	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	6.85e-03	1.00e+00	7.187	1	5	9
GO:0042405	nuclear inclusion body	6.85e-03	1.00e+00	7.187	1	2	9
GO:0048188	Set1C/COMPASS complex	6.85e-03	1.00e+00	7.187	1	4	9
GO:0043495	protein anchor	6.85e-03	1.00e+00	7.187	1	1	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	6.85e-03	1.00e+00	7.187	1	5	9
GO:0044212	transcription regulatory region DNA binding	6.92e-03	1.00e+00	3.964	2	17	168
GO:0035413	positive regulation of catenin import into nucleus	7.60e-03	1.00e+00	7.035	1	2	10
GO:0000145	exocyst	7.60e-03	1.00e+00	7.035	1	1	10
GO:0060391	positive regulation of SMAD protein import into nucleus	8.36e-03	1.00e+00	6.897	1	4	11
GO:0030667	secretory granule membrane	9.12e-03	1.00e+00	6.772	1	2	12
GO:0045947	negative regulation of translational initiation	9.12e-03	1.00e+00	6.772	1	2	12
GO:0034045	pre-autophagosomal structure membrane	9.12e-03	1.00e+00	6.772	1	2	12
GO:0034399	nuclear periphery	9.12e-03	1.00e+00	6.772	1	5	12
GO:0005838	proteasome regulatory particle	9.12e-03	1.00e+00	6.772	1	1	12
GO:0035198	miRNA binding	9.12e-03	1.00e+00	6.772	1	1	12
GO:0071480	cellular response to gamma radiation	9.87e-03	1.00e+00	6.656	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	9.87e-03	1.00e+00	6.656	1	2	13
GO:0051019	mitogen-activated protein kinase binding	9.87e-03	1.00e+00	6.656	1	2	13
GO:0000407	pre-autophagosomal structure	9.87e-03	1.00e+00	6.656	1	2	13
GO:0005868	cytoplasmic dynein complex	9.87e-03	1.00e+00	6.656	1	1	13
GO:0030234	enzyme regulator activity	9.87e-03	1.00e+00	6.656	1	2	13
GO:0046827	positive regulation of protein export from nucleus	9.87e-03	1.00e+00	6.656	1	1	13
GO:0031011	Ino80 complex	1.06e-02	1.00e+00	6.549	1	6	14
GO:0005487	nucleocytoplasmic transporter activity	1.06e-02	1.00e+00	6.549	1	3	14
GO:0043981	histone H4-K5 acetylation	1.14e-02	1.00e+00	6.450	1	5	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	1.14e-02	1.00e+00	6.450	1	3	15
GO:0042307	positive regulation of protein import into nucleus	1.14e-02	1.00e+00	6.450	1	4	15
GO:0001824	blastocyst development	1.14e-02	1.00e+00	6.450	1	2	15
GO:0043982	histone H4-K8 acetylation	1.14e-02	1.00e+00	6.450	1	5	15
GO:0000422	mitochondrion degradation	1.14e-02	1.00e+00	6.450	1	1	15
GO:0043274	phospholipase binding	1.21e-02	1.00e+00	6.357	1	1	16
GO:0042176	regulation of protein catabolic process	1.21e-02	1.00e+00	6.357	1	2	16
GO:0008380	RNA splicing	1.25e-02	1.00e+00	3.524	2	22	228
GO:0090316	positive regulation of intracellular protein transport	1.29e-02	1.00e+00	6.269	1	2	17
GO:0022624	proteasome accessory complex	1.29e-02	1.00e+00	6.269	1	1	17
GO:0003713	transcription coactivator activity	1.34e-02	1.00e+00	3.468	2	24	237
GO:0031418	L-ascorbic acid binding	1.36e-02	1.00e+00	6.187	1	1	18
GO:0043984	histone H4-K16 acetylation	1.44e-02	1.00e+00	6.109	1	5	19
GO:0000123	histone acetyltransferase complex	1.59e-02	1.00e+00	5.964	1	6	21
GO:0045787	positive regulation of cell cycle	1.67e-02	1.00e+00	5.897	1	2	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.67e-02	1.00e+00	5.897	1	4	22
GO:0006611	protein export from nucleus	1.89e-02	1.00e+00	5.713	1	3	25
GO:0035329	hippo signaling	1.97e-02	1.00e+00	5.656	1	5	26
GO:0000045	autophagic vacuole assembly	1.97e-02	1.00e+00	5.656	1	2	26
GO:0015631	tubulin binding	2.04e-02	1.00e+00	5.602	1	2	27
GO:0071339	MLL1 complex	2.04e-02	1.00e+00	5.602	1	6	27
GO:0034605	cellular response to heat	2.12e-02	1.00e+00	5.549	1	1	28
GO:0072686	mitotic spindle	2.19e-02	1.00e+00	5.499	1	3	29
GO:0006606	protein import into nucleus	2.27e-02	1.00e+00	5.450	1	2	30
GO:0031647	regulation of protein stability	2.27e-02	1.00e+00	5.450	1	4	30
GO:0010827	regulation of glucose transport	2.27e-02	1.00e+00	5.450	1	4	30
GO:0007094	mitotic spindle assembly checkpoint	2.34e-02	1.00e+00	5.402	1	3	31
GO:1903507	negative regulation of nucleic acid-templated transcription	2.41e-02	1.00e+00	5.357	1	2	32
GO:0003682	chromatin binding	2.46e-02	1.00e+00	3.004	2	19	327
GO:0031072	heat shock protein binding	2.49e-02	1.00e+00	5.312	1	2	33
GO:0003723	RNA binding	2.68e-02	1.00e+00	2.939	2	18	342
GO:0007077	mitotic nuclear envelope disassembly	2.71e-02	1.00e+00	5.187	1	4	36
GO:0030199	collagen fibril organization	2.79e-02	1.00e+00	5.147	1	2	37
GO:0008645	hexose transport	2.94e-02	1.00e+00	5.071	1	4	39
GO:0035019	somatic stem cell maintenance	3.01e-02	1.00e+00	5.035	1	6	40
GO:0016020	membrane	3.09e-02	1.00e+00	1.642	4	46	1681
GO:0031124	mRNA 3'-end processing	3.16e-02	1.00e+00	4.964	1	2	42
GO:0006369	termination of RNA polymerase II transcription	3.38e-02	1.00e+00	4.865	1	2	45
GO:0000278	mitotic cell cycle	3.43e-02	1.00e+00	2.746	2	15	391
GO:0005811	lipid particle	3.53e-02	1.00e+00	4.802	1	1	47
GO:0006521	regulation of cellular amino acid metabolic process	3.75e-02	1.00e+00	4.713	1	1	50
GO:0009611	response to wounding	3.90e-02	1.00e+00	4.656	1	5	52
GO:0015758	glucose transport	4.12e-02	1.00e+00	4.575	1	4	55
GO:0005643	nuclear pore	4.26e-02	1.00e+00	4.524	1	11	57
GO:0000502	proteasome complex	4.34e-02	1.00e+00	4.499	1	3	58
GO:0006396	RNA processing	4.41e-02	1.00e+00	4.474	1	5	59
GO:0006406	mRNA export from nucleus	4.56e-02	1.00e+00	4.426	1	4	61
GO:0000776	kinetochore	4.70e-02	1.00e+00	4.379	1	5	63
GO:0006887	exocytosis	4.78e-02	1.00e+00	4.357	1	2	64
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.78e-02	1.00e+00	4.357	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.85e-02	1.00e+00	4.334	1	2	65
GO:0006310	DNA recombination	4.85e-02	1.00e+00	4.334	1	7	65
GO:0010468	regulation of gene expression	5.07e-02	1.00e+00	4.269	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.21e-02	1.00e+00	4.227	1	2	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.36e-02	1.00e+00	4.187	1	1	72
GO:0003729	mRNA binding	5.36e-02	1.00e+00	4.187	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.50e-02	1.00e+00	4.147	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.50e-02	1.00e+00	4.147	1	2	74
GO:0002020	protease binding	5.50e-02	1.00e+00	4.147	1	6	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.58e-02	1.00e+00	4.128	1	1	75
GO:0071013	catalytic step 2 spliceosome	5.79e-02	1.00e+00	4.071	1	7	78
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.86e-02	1.00e+00	4.053	1	2	79
GO:0003677	DNA binding	5.93e-02	1.00e+00	1.691	3	49	1218
GO:0016032	viral process	6.03e-02	1.00e+00	2.296	2	26	534
GO:0009653	anatomical structure morphogenesis	6.15e-02	1.00e+00	3.982	1	2	83
GO:0050821	protein stabilization	6.51e-02	1.00e+00	3.897	1	3	88
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	6.77e-02	1.00e+00	2.202	2	37	570
GO:0001649	osteoblast differentiation	6.80e-02	1.00e+00	3.833	1	5	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.80e-02	1.00e+00	3.833	1	1	92
GO:0005506	iron ion binding	7.73e-02	1.00e+00	3.642	1	3	105
GO:0030529	ribonucleoprotein complex	8.22e-02	1.00e+00	3.549	1	5	112
GO:0005635	nuclear envelope	8.29e-02	1.00e+00	3.536	1	5	113
GO:0000209	protein polyubiquitination	8.50e-02	1.00e+00	3.499	1	3	116
GO:0006325	chromatin organization	8.64e-02	1.00e+00	3.474	1	12	118
GO:0005215	transporter activity	9.48e-02	1.00e+00	3.334	1	3	130
GO:0003700	sequence-specific DNA binding transcription factor activity	9.66e-02	1.00e+00	1.908	2	39	699
GO:0005634	nucleus	9.78e-02	1.00e+00	0.787	6	159	4559
GO:0005788	endoplasmic reticulum lumen	1.05e-01	1.00e+00	3.177	1	5	145
GO:0061024	membrane organization	1.05e-01	1.00e+00	3.177	1	4	145
GO:0010628	positive regulation of gene expression	1.06e-01	1.00e+00	3.167	1	7	146
GO:0000082	G1/S transition of mitotic cell cycle	1.08e-01	1.00e+00	3.137	1	3	149
GO:0006974	cellular response to DNA damage stimulus	1.09e-01	1.00e+00	3.118	1	7	151
GO:0042981	regulation of apoptotic process	1.09e-01	1.00e+00	3.128	1	4	150
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.19e-01	1.00e+00	1.733	2	41	789
GO:0031965	nuclear membrane	1.21e-01	1.00e+00	2.964	1	10	168
GO:0034641	cellular nitrogen compound metabolic process	1.23e-01	1.00e+00	2.939	1	2	171
GO:0016607	nuclear speck	1.24e-01	1.00e+00	2.930	1	12	172
GO:0007049	cell cycle	1.25e-01	1.00e+00	2.914	1	6	174
GO:0005667	transcription factor complex	1.26e-01	1.00e+00	2.905	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.28e-01	1.00e+00	2.881	1	5	178
GO:0003714	transcription corepressor activity	1.28e-01	1.00e+00	2.881	1	11	178
GO:0006367	transcription initiation from RNA polymerase II promoter	1.32e-01	1.00e+00	2.833	1	22	184
GO:0005737	cytoplasm	1.33e-01	1.00e+00	0.799	5	124	3767
GO:0019221	cytokine-mediated signaling pathway	1.56e-01	1.00e+00	2.569	1	8	221
GO:0016071	mRNA metabolic process	1.58e-01	1.00e+00	2.556	1	8	223
GO:0007067	mitotic nuclear division	1.60e-01	1.00e+00	2.530	1	6	227
GO:0008134	transcription factor binding	1.70e-01	1.00e+00	2.438	1	18	242
GO:0043025	neuronal cell body	1.72e-01	1.00e+00	2.420	1	9	245
GO:0016070	RNA metabolic process	1.73e-01	1.00e+00	2.408	1	8	247
GO:0005739	mitochondrion	1.74e-01	1.00e+00	1.394	2	23	998
GO:0005975	carbohydrate metabolic process	1.77e-01	1.00e+00	2.374	1	8	253
GO:0000166	nucleotide binding	1.81e-01	1.00e+00	2.340	1	13	259
GO:0006281	DNA repair	1.82e-01	1.00e+00	2.329	1	14	261
GO:0006954	inflammatory response	1.92e-01	1.00e+00	2.243	1	6	277
GO:0043231	intracellular membrane-bounded organelle	2.18e-01	1.00e+00	2.044	1	6	318
GO:0008283	cell proliferation	2.24e-01	1.00e+00	1.999	1	14	328
GO:0015031	protein transport	2.31e-01	1.00e+00	1.943	1	11	341
GO:0043565	sequence-specific DNA binding	2.34e-01	1.00e+00	1.922	1	11	346
GO:0044281	small molecule metabolic process	2.35e-01	1.00e+00	1.115	2	20	1211
GO:0009986	cell surface	2.67e-01	1.00e+00	1.706	1	9	402
GO:0055114	oxidation-reduction process	2.78e-01	1.00e+00	1.642	1	10	420
GO:0043066	negative regulation of apoptotic process	2.80e-01	1.00e+00	1.629	1	16	424
GO:0055085	transmembrane transport	2.86e-01	1.00e+00	1.592	1	8	435
GO:0005829	cytosol	2.94e-01	1.00e+00	0.656	3	86	2496
GO:0044267	cellular protein metabolic process	3.08e-01	1.00e+00	1.468	1	20	474
GO:0042802	identical protein binding	3.13e-01	1.00e+00	1.438	1	19	484
GO:0006915	apoptotic process	3.51e-01	1.00e+00	1.240	1	12	555
GO:0005783	endoplasmic reticulum	3.51e-01	1.00e+00	1.238	1	13	556
GO:0005730	nucleolus	3.61e-01	1.00e+00	0.676	2	66	1641
GO:0042803	protein homodimerization activity	3.71e-01	1.00e+00	1.140	1	19	595
GO:0005524	ATP binding	6.46e-01	1.00e+00	0.015	1	31	1298
GO:0070062	extracellular vesicular exosome	8.65e-01	1.00e+00	-0.872	1	57	2400

chia-Fav

int-snw-5033

Statistics

Genes (11)

Interactions (10)

Related GO terms (197)