int-snw-4927

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.843	1.38e-15	4.43e-04	3.18e-03

chia-screen-data-Fav-int-snw-4927 subnetwork

Genes (15)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
MED19	219541	30	-2.657	3.449	115	Yes	-
[ NUP88 ]	4927	1	-1.654	2.843	19	-	-
NCBP1	4686	6	-2.510	3.149	40	Yes	Yes
MCRS1	10445	14	-2.660	3.079	63	Yes	Yes
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
MED28	80306	16	-2.404	3.216	80	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
NXF1	10482	10	-2.426	3.538	65	Yes	Yes
MED12	9968	14	-2.465	3.206	65	Yes	-
MED17	9440	2	-2.161	2.860	51	Yes	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
SRSF3	6428	73	-2.992	3.538	54	Yes	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
MED4	29079	2	-1.785	2.860	44	-	-

Interactions (24)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
NFRKB	4798	MCRS1	10445	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
SRSF3	6428	NXF1	10482	pp	--	int.I2D: MINT, HPRD; int.Mint: MI:0407(direct interaction), MI:0915(physical association)
MCRS1	10445	MED4	29079	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, HPRD, MINT, VidalHuman_core, IntAct; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
MED12	9968	MED28	80306	pp	--	int.I2D: BioGrid
MED12	9968	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
MED17	9440	MED12	9968	pp	--	int.I2D: BioGrid
NCBP1	4686	NXF1	10482	pp	--	int.Mint: MI:0914(association)
MED17	9440	MED28	80306	pp	--	int.I2D: BioGrid, BioGrid_Fly, IntAct_Fly
NUP88	4927	NXF1	10482	pp	--	int.Intact: MI:0914(association)
YAP1	10413	MED28	80306	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
HNRNPU	3192	NXF1	10482	pp	--	int.Intact: MI:0914(association)
MED17	9440	MED4	29079	pp	--	int.I2D: IntAct_Fly
NUP88	4927	MED4	29079	pp	--	int.I2D: BioGrid_Fly, BIND_Fly, FlyLow, IntAct_Fly, MINT_Fly
MED17	9440	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct, BIND, HPRD; int.HPRD: in vitro
MED12	9968	MED4	29079	pp	--	int.I2D: BioGrid, MINT; int.Mint: MI:0915(physical association), MI:0914(association)
MED28	80306	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
MED4	29079	MED28	80306	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
MED4	29079	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct

Related GO terms (150)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016592	mediator complex	1.84e-10	2.66e-06	7.102	5	10	35
GO:0005654	nucleoplasm	1.15e-08	1.66e-04	3.152	10	64	1082
GO:0001104	RNA polymerase II transcription cofactor activity	3.04e-08	4.39e-04	6.865	4	8	33
GO:0010467	gene expression	9.90e-08	1.43e-03	3.523	8	45	669
GO:0030518	intracellular steroid hormone receptor signaling pathway	3.29e-07	4.75e-03	7.687	3	6	14
GO:0042809	vitamin D receptor binding	4.11e-07	5.93e-03	7.587	3	6	15
GO:0006366	transcription from RNA polymerase II promoter	2.32e-06	3.35e-02	3.783	6	30	419
GO:0046966	thyroid hormone receptor binding	2.33e-06	3.36e-02	6.794	3	6	26
GO:0030521	androgen receptor signaling pathway	9.47e-06	1.37e-01	6.137	3	5	41
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	1.10e-05	1.58e-01	6.068	3	7	43
GO:0003712	transcription cofactor activity	1.17e-05	1.69e-01	6.035	3	8	44
GO:0019827	stem cell maintenance	1.44e-05	2.07e-01	5.940	3	7	47
GO:0006367	transcription initiation from RNA polymerase II promoter	3.14e-05	4.52e-01	4.386	4	22	184
GO:0006406	mRNA export from nucleus	3.16e-05	4.56e-01	5.563	3	4	61
GO:0008380	RNA splicing	7.24e-05	1.00e+00	4.076	4	22	228
GO:0031011	Ino80 complex	9.12e-05	1.00e+00	7.102	2	6	14
GO:0005634	nucleus	1.60e-04	1.00e+00	1.340	12	159	4559
GO:0044822	poly(A) RNA binding	4.27e-04	1.00e+00	2.450	6	50	1056
GO:0000398	mRNA splicing, via spliceosome	5.94e-04	1.00e+00	4.137	3	15	164
GO:0016607	nuclear speck	6.82e-04	1.00e+00	4.068	3	12	172
GO:0031124	mRNA 3'-end processing	8.49e-04	1.00e+00	5.517	2	2	42
GO:0004872	receptor activity	8.97e-04	1.00e+00	3.932	3	8	189
GO:0006369	termination of RNA polymerase II transcription	9.74e-04	1.00e+00	5.417	2	2	45
GO:0060795	cell fate commitment involved in formation of primary germ layer	1.04e-03	1.00e+00	9.909	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	1.04e-03	1.00e+00	9.909	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	1.04e-03	1.00e+00	9.909	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	1.04e-03	1.00e+00	9.909	1	1	1
GO:0005643	nuclear pore	1.56e-03	1.00e+00	5.076	2	11	57
GO:0003713	transcription coactivator activity	1.72e-03	1.00e+00	3.605	3	24	237
GO:0006310	DNA recombination	2.02e-03	1.00e+00	4.887	2	7	65
GO:0060242	contact inhibition	2.08e-03	1.00e+00	8.909	1	1	2
GO:0005846	nuclear cap binding complex	2.08e-03	1.00e+00	8.909	1	1	2
GO:0009786	regulation of asymmetric cell division	2.08e-03	1.00e+00	8.909	1	1	2
GO:0006357	regulation of transcription from RNA polymerase II promoter	2.34e-03	1.00e+00	3.450	3	23	264
GO:0003729	mRNA binding	2.47e-03	1.00e+00	4.739	2	4	72
GO:0006355	regulation of transcription, DNA-templated	2.61e-03	1.00e+00	2.270	5	43	997
GO:0005515	protein binding	2.98e-03	1.00e+00	0.938	12	198	6024
GO:0060913	cardiac cell fate determination	3.12e-03	1.00e+00	8.324	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	3.12e-03	1.00e+00	8.324	1	1	3
GO:0090245	axis elongation involved in somitogenesis	3.12e-03	1.00e+00	8.324	1	1	3
GO:0014044	Schwann cell development	4.15e-03	1.00e+00	7.909	1	1	4
GO:0051151	negative regulation of smooth muscle cell differentiation	4.15e-03	1.00e+00	7.909	1	1	4
GO:0005730	nucleolus	4.33e-03	1.00e+00	1.814	6	66	1641
GO:0003723	RNA binding	4.86e-03	1.00e+00	3.076	3	18	342
GO:0001714	endodermal cell fate specification	5.19e-03	1.00e+00	7.587	1	1	5
GO:0045292	mRNA cis splicing, via spliceosome	5.19e-03	1.00e+00	7.587	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	5.19e-03	1.00e+00	7.587	1	2	5
GO:0031442	positive regulation of mRNA 3'-end processing	5.19e-03	1.00e+00	7.587	1	1	5
GO:0030529	ribonucleoprotein complex	5.87e-03	1.00e+00	4.102	2	5	112
GO:0070937	CRD-mediated mRNA stability complex	6.22e-03	1.00e+00	7.324	1	3	6
GO:0016973	poly(A)+ mRNA export from nucleus	8.29e-03	1.00e+00	6.909	1	1	8
GO:0000339	RNA cap binding	8.29e-03	1.00e+00	6.909	1	1	8
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	9.32e-03	1.00e+00	6.739	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	9.32e-03	1.00e+00	6.739	1	5	9
GO:0042405	nuclear inclusion body	9.32e-03	1.00e+00	6.739	1	2	9
GO:0006379	mRNA cleavage	9.32e-03	1.00e+00	6.739	1	1	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	9.32e-03	1.00e+00	6.739	1	5	9
GO:0035413	positive regulation of catenin import into nucleus	1.04e-02	1.00e+00	6.587	1	2	10
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	1.04e-02	1.00e+00	6.587	1	1	10
GO:0005845	mRNA cap binding complex	1.14e-02	1.00e+00	6.450	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	1.14e-02	1.00e+00	6.450	1	4	11
GO:0045893	positive regulation of transcription, DNA-templated	1.22e-02	1.00e+00	2.593	3	24	478
GO:0008334	histone mRNA metabolic process	1.24e-02	1.00e+00	6.324	1	1	12
GO:0035198	miRNA binding	1.24e-02	1.00e+00	6.324	1	1	12
GO:0044212	transcription regulatory region DNA binding	1.28e-02	1.00e+00	3.517	2	17	168
GO:0071480	cellular response to gamma radiation	1.34e-02	1.00e+00	6.209	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	1.34e-02	1.00e+00	6.209	1	2	13
GO:0000346	transcription export complex	1.34e-02	1.00e+00	6.209	1	1	13
GO:0005667	transcription factor complex	1.39e-02	1.00e+00	3.458	2	17	175
GO:0005685	U1 snRNP	1.45e-02	1.00e+00	6.102	1	1	14
GO:0005487	nucleocytoplasmic transporter activity	1.45e-02	1.00e+00	6.102	1	3	14
GO:0043981	histone H4-K5 acetylation	1.55e-02	1.00e+00	6.002	1	5	15
GO:0001824	blastocyst development	1.55e-02	1.00e+00	6.002	1	2	15
GO:0043982	histone H4-K8 acetylation	1.55e-02	1.00e+00	6.002	1	5	15
GO:0006376	mRNA splice site selection	1.55e-02	1.00e+00	6.002	1	1	15
GO:0043274	phospholipase binding	1.65e-02	1.00e+00	5.909	1	1	16
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	1.65e-02	1.00e+00	5.909	1	2	16
GO:0016032	viral process	1.65e-02	1.00e+00	2.433	3	26	534
GO:0043984	histone H4-K16 acetylation	1.96e-02	1.00e+00	5.661	1	5	19
GO:0014003	oligodendrocyte development	2.06e-02	1.00e+00	5.587	1	5	20
GO:0000123	histone acetyltransferase complex	2.16e-02	1.00e+00	5.517	1	6	21
GO:0036464	cytoplasmic ribonucleoprotein granule	2.26e-02	1.00e+00	5.450	1	2	22
GO:0016020	membrane	2.36e-02	1.00e+00	1.516	5	46	1681
GO:0030864	cortical actin cytoskeleton	2.37e-02	1.00e+00	5.386	1	1	23
GO:0034660	ncRNA metabolic process	2.37e-02	1.00e+00	5.386	1	1	23
GO:0031047	gene silencing by RNA	2.57e-02	1.00e+00	5.265	1	2	25
GO:0035329	hippo signaling	2.67e-02	1.00e+00	5.209	1	5	26
GO:0000387	spliceosomal snRNP assembly	2.77e-02	1.00e+00	5.154	1	2	27
GO:0071339	MLL1 complex	2.77e-02	1.00e+00	5.154	1	6	27
GO:0000166	nucleotide binding	2.89e-02	1.00e+00	2.892	2	13	259
GO:0006281	DNA repair	2.93e-02	1.00e+00	2.881	2	14	261
GO:0006370	7-methylguanosine mRNA capping	3.08e-02	1.00e+00	5.002	1	5	30
GO:0010827	regulation of glucose transport	3.08e-02	1.00e+00	5.002	1	4	30
GO:0003677	DNA binding	3.25e-02	1.00e+00	1.659	4	49	1218
GO:1903507	negative regulation of nucleic acid-templated transcription	3.28e-02	1.00e+00	4.909	1	2	32
GO:0030178	negative regulation of Wnt signaling pathway	3.58e-02	1.00e+00	4.780	1	4	35
GO:0007077	mitotic nuclear envelope disassembly	3.68e-02	1.00e+00	4.739	1	4	36
GO:0006446	regulation of translational initiation	3.68e-02	1.00e+00	4.739	1	4	36
GO:0008645	hexose transport	3.98e-02	1.00e+00	4.624	1	4	39
GO:0035019	somatic stem cell maintenance	4.08e-02	1.00e+00	4.587	1	6	40
GO:0050434	positive regulation of viral transcription	4.48e-02	1.00e+00	4.450	1	5	44
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	4.53e-02	1.00e+00	1.870	3	41	789
GO:0051028	mRNA transport	5.28e-02	1.00e+00	4.209	1	4	52
GO:0009611	response to wounding	5.28e-02	1.00e+00	4.209	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	5.38e-02	1.00e+00	4.181	1	5	53
GO:0015758	glucose transport	5.57e-02	1.00e+00	4.128	1	4	55
GO:0006396	RNA processing	5.97e-02	1.00e+00	4.027	1	5	59
GO:0008013	beta-catenin binding	6.06e-02	1.00e+00	4.002	1	9	60
GO:0006368	transcription elongation from RNA polymerase II promoter	6.75e-02	1.00e+00	3.843	1	6	67
GO:0010468	regulation of gene expression	6.85e-02	1.00e+00	3.822	1	2	68
GO:0001843	neural tube closure	7.43e-02	1.00e+00	3.700	1	2	74
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	7.43e-02	1.00e+00	3.700	1	4	74
GO:0002020	protease binding	7.43e-02	1.00e+00	3.700	1	6	74
GO:0060070	canonical Wnt signaling pathway	7.53e-02	1.00e+00	3.680	1	4	75
GO:0071013	catalytic step 2 spliceosome	7.82e-02	1.00e+00	3.624	1	7	78
GO:0009653	anatomical structure morphogenesis	8.30e-02	1.00e+00	3.534	1	2	83
GO:0006464	cellular protein modification process	8.39e-02	1.00e+00	3.517	1	4	84
GO:0001649	osteoblast differentiation	9.16e-02	1.00e+00	3.386	1	5	92
GO:0005829	cytosol	1.02e-01	1.00e+00	0.946	5	86	2496
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1.12e-01	1.00e+00	3.076	1	4	114
GO:0006325	chromatin organization	1.16e-01	1.00e+00	3.027	1	12	118
GO:0005215	transporter activity	1.27e-01	1.00e+00	2.887	1	3	130
GO:0007507	heart development	1.35e-01	1.00e+00	2.790	1	7	139
GO:0006974	cellular response to DNA damage stimulus	1.46e-01	1.00e+00	2.671	1	7	151
GO:0008022	protein C-terminus binding	1.55e-01	1.00e+00	2.578	1	8	161
GO:0031625	ubiquitin protein ligase binding	1.70e-01	1.00e+00	2.433	1	5	178
GO:0003714	transcription corepressor activity	1.70e-01	1.00e+00	2.433	1	11	178
GO:0019904	protein domain specific binding	1.71e-01	1.00e+00	2.425	1	8	179
GO:0019221	cytokine-mediated signaling pathway	2.07e-01	1.00e+00	2.121	1	8	221
GO:0016071	mRNA metabolic process	2.09e-01	1.00e+00	2.108	1	8	223
GO:0008134	transcription factor binding	2.24e-01	1.00e+00	1.990	1	18	242
GO:0016070	RNA metabolic process	2.28e-01	1.00e+00	1.961	1	8	247
GO:0005975	carbohydrate metabolic process	2.33e-01	1.00e+00	1.926	1	8	253
GO:0003779	actin binding	2.44e-01	1.00e+00	1.854	1	10	266
GO:0006954	inflammatory response	2.53e-01	1.00e+00	1.795	1	6	277
GO:0003682	chromatin binding	2.91e-01	1.00e+00	1.556	1	19	327
GO:0008283	cell proliferation	2.92e-01	1.00e+00	1.552	1	14	328
GO:0015031	protein transport	3.02e-01	1.00e+00	1.496	1	11	341
GO:0043565	sequence-specific DNA binding	3.05e-01	1.00e+00	1.475	1	11	346
GO:0005925	focal adhesion	3.20e-01	1.00e+00	1.393	1	9	366
GO:0000278	mitotic cell cycle	3.38e-01	1.00e+00	1.298	1	15	391
GO:0009986	cell surface	3.46e-01	1.00e+00	1.258	1	9	402
GO:0005737	cytoplasm	3.51e-01	1.00e+00	0.352	5	124	3767
GO:0055085	transmembrane transport	3.68e-01	1.00e+00	1.144	1	8	435
GO:0006351	transcription, DNA-templated	4.52e-01	1.00e+00	0.411	2	57	1446
GO:0003700	sequence-specific DNA binding transcription factor activity	5.26e-01	1.00e+00	0.460	1	39	699
GO:0005739	mitochondrion	6.59e-01	1.00e+00	-0.054	1	23	998
GO:0044281	small molecule metabolic process	7.32e-01	1.00e+00	-0.333	1	20	1211
GO:0005524	ATP binding	7.57e-01	1.00e+00	-0.433	1	31	1298
GO:0005886	plasma membrane	7.79e-01	1.00e+00	-0.425	2	49	2582

chia-Fav

int-snw-4927

Statistics

Genes (15)

Interactions (24)

Related GO terms (150)