int-snw-29079

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.860	9.00e-16	3.59e-04	2.74e-03

chia-screen-data-Fav-int-snw-29079 subnetwork

Genes (15)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
RNF40	9810	2	-2.082	2.938	25	Yes	-
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
APLP2	334	12	-2.732	3.206	35	Yes	Yes
MED19	219541	30	-2.657	3.449	115	Yes	-
MCRS1	10445	14	-2.660	3.079	63	Yes	Yes
TNFAIP8	25816	1	-1.978	2.860	7	-	-
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
MED28	80306	16	-2.404	3.216	80	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
MED12	9968	14	-2.465	3.206	65	Yes	-
MED17	9440	2	-2.161	2.860	51	Yes	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
[ MED4 ]	29079	2	-1.785	2.860	44	-	-

Interactions (22)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
MED17	9440	MED4	29079	pp	--	int.I2D: IntAct_Fly
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
MED17	9440	MED12	9968	pp	--	int.I2D: BioGrid
MCRS1	10445	MED4	29079	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, HPRD, MINT, VidalHuman_core, IntAct; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
HCFC1	3054	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
MED28	80306	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
YAP1	10413	MED28	80306	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
MED4	29079	MED28	80306	pp	--	int.I2D: BioGrid
APLP2	334	MED12	9968	pp	--	int.I2D: MINT; int.Mint: MI:0407(direct interaction)
NFRKB	4798	MCRS1	10445	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
MED17	9440	MED28	80306	pp	--	int.I2D: BioGrid, BioGrid_Fly, IntAct_Fly
MED12	9968	MED28	80306	pp	--	int.I2D: BioGrid
MED12	9968	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
TNFAIP8	25816	MED4	29079	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, MINT, VidalHuman_core, HPRD, IntAct; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
MED17	9440	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct, BIND, HPRD; int.HPRD: in vitro
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
RNF40	9810	MED4	29079	pp	--	int.I2D: VidalHuman_non_core
MED4	29079	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MED12	9968	MED4	29079	pp	--	int.I2D: BioGrid, MINT; int.Mint: MI:0915(physical association), MI:0914(association)

Related GO terms (155)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016592	mediator complex	1.84e-10	2.66e-06	7.102	5	10	35
GO:0001104	RNA polymerase II transcription cofactor activity	3.04e-08	4.39e-04	6.865	4	8	33
GO:0030518	intracellular steroid hormone receptor signaling pathway	3.29e-07	4.75e-03	7.687	3	6	14
GO:0042809	vitamin D receptor binding	4.11e-07	5.93e-03	7.587	3	6	15
GO:0006366	transcription from RNA polymerase II promoter	2.32e-06	3.35e-02	3.783	6	30	419
GO:0046966	thyroid hormone receptor binding	2.33e-06	3.36e-02	6.794	3	6	26
GO:0005654	nucleoplasm	3.91e-06	5.63e-02	2.830	8	64	1082
GO:0030521	androgen receptor signaling pathway	9.47e-06	1.37e-01	6.137	3	5	41
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	1.10e-05	1.58e-01	6.068	3	7	43
GO:0003712	transcription cofactor activity	1.17e-05	1.69e-01	6.035	3	8	44
GO:0019827	stem cell maintenance	1.44e-05	2.07e-01	5.940	3	7	47
GO:0006367	transcription initiation from RNA polymerase II promoter	3.14e-05	4.52e-01	4.386	4	22	184
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	3.62e-05	5.22e-01	7.739	2	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	3.62e-05	5.22e-01	7.739	2	5	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	3.62e-05	5.22e-01	7.739	2	5	9
GO:0003713	transcription coactivator activity	8.41e-05	1.00e+00	4.020	4	24	237
GO:0031011	Ino80 complex	9.12e-05	1.00e+00	7.102	2	6	14
GO:0043981	histone H4-K5 acetylation	1.05e-04	1.00e+00	7.002	2	5	15
GO:0043982	histone H4-K8 acetylation	1.05e-04	1.00e+00	7.002	2	5	15
GO:0005634	nucleus	1.60e-04	1.00e+00	1.340	12	159	4559
GO:0043984	histone H4-K16 acetylation	1.71e-04	1.00e+00	6.661	2	5	19
GO:0000123	histone acetyltransferase complex	2.10e-04	1.00e+00	6.517	2	6	21
GO:0006355	regulation of transcription, DNA-templated	3.13e-04	1.00e+00	2.533	6	43	997
GO:0071339	MLL1 complex	3.49e-04	1.00e+00	6.154	2	6	27
GO:0010467	gene expression	4.31e-04	1.00e+00	2.845	5	45	669
GO:0016020	membrane	7.94e-04	1.00e+00	2.001	7	46	1681
GO:0004872	receptor activity	8.97e-04	1.00e+00	3.932	3	8	189
GO:0060795	cell fate commitment involved in formation of primary germ layer	1.04e-03	1.00e+00	9.909	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	1.04e-03	1.00e+00	9.909	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	1.04e-03	1.00e+00	9.909	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	1.04e-03	1.00e+00	9.909	1	1	1
GO:0006310	DNA recombination	2.02e-03	1.00e+00	4.887	2	7	65
GO:0060242	contact inhibition	2.08e-03	1.00e+00	8.909	1	1	2
GO:0019046	release from viral latency	2.08e-03	1.00e+00	8.909	1	2	2
GO:0009786	regulation of asymmetric cell division	2.08e-03	1.00e+00	8.909	1	1	2
GO:0006357	regulation of transcription from RNA polymerase II promoter	2.34e-03	1.00e+00	3.450	3	23	264
GO:0005515	protein binding	2.98e-03	1.00e+00	0.938	12	198	6024
GO:0046914	transition metal ion binding	3.12e-03	1.00e+00	8.324	1	1	3
GO:0060913	cardiac cell fate determination	3.12e-03	1.00e+00	8.324	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	3.12e-03	1.00e+00	8.324	1	1	3
GO:0090245	axis elongation involved in somitogenesis	3.12e-03	1.00e+00	8.324	1	1	3
GO:0014044	Schwann cell development	4.15e-03	1.00e+00	7.909	1	1	4
GO:0051151	negative regulation of smooth muscle cell differentiation	4.15e-03	1.00e+00	7.909	1	1	4
GO:0032611	interleukin-1 beta production	4.15e-03	1.00e+00	7.909	1	1	4
GO:0033503	HULC complex	4.15e-03	1.00e+00	7.909	1	1	4
GO:0070461	SAGA-type complex	5.19e-03	1.00e+00	7.587	1	2	5
GO:0001714	endodermal cell fate specification	5.19e-03	1.00e+00	7.587	1	1	5
GO:0007176	regulation of epidermal growth factor-activated receptor activity	5.19e-03	1.00e+00	7.587	1	1	5
GO:0006325	chromatin organization	6.50e-03	1.00e+00	4.027	2	12	118
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	7.47e-03	1.00e+00	2.285	4	41	789
GO:0007617	mating behavior	8.29e-03	1.00e+00	6.909	1	1	8
GO:0070688	MLL5-L complex	8.29e-03	1.00e+00	6.909	1	1	8
GO:0043254	regulation of protein complex assembly	8.29e-03	1.00e+00	6.909	1	1	8
GO:0033523	histone H2B ubiquitination	8.29e-03	1.00e+00	6.909	1	1	8
GO:0048188	Set1C/COMPASS complex	9.32e-03	1.00e+00	6.739	1	4	9
GO:0035413	positive regulation of catenin import into nucleus	1.04e-02	1.00e+00	6.587	1	2	10
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	1.04e-02	1.00e+00	6.587	1	1	10
GO:0010390	histone monoubiquitination	1.14e-02	1.00e+00	6.450	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	1.14e-02	1.00e+00	6.450	1	4	11
GO:0045893	positive regulation of transcription, DNA-templated	1.22e-02	1.00e+00	2.593	3	24	478
GO:0006878	cellular copper ion homeostasis	1.24e-02	1.00e+00	6.324	1	1	12
GO:0035198	miRNA binding	1.24e-02	1.00e+00	6.324	1	1	12
GO:0044212	transcription regulatory region DNA binding	1.28e-02	1.00e+00	3.517	2	17	168
GO:0016607	nuclear speck	1.34e-02	1.00e+00	3.483	2	12	172
GO:0071480	cellular response to gamma radiation	1.34e-02	1.00e+00	6.209	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	1.34e-02	1.00e+00	6.209	1	2	13
GO:0005667	transcription factor complex	1.39e-02	1.00e+00	3.458	2	17	175
GO:0031625	ubiquitin protein ligase binding	1.43e-02	1.00e+00	3.433	2	5	178
GO:0001967	suckling behavior	1.45e-02	1.00e+00	6.102	1	1	14
GO:0005685	U1 snRNP	1.45e-02	1.00e+00	6.102	1	1	14
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	1.55e-02	1.00e+00	6.002	1	3	15
GO:0001824	blastocyst development	1.55e-02	1.00e+00	6.002	1	2	15
GO:0006376	mRNA splice site selection	1.55e-02	1.00e+00	6.002	1	1	15
GO:0043274	phospholipase binding	1.65e-02	1.00e+00	5.909	1	1	16
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	1.65e-02	1.00e+00	5.909	1	2	16
GO:0017075	syntaxin-1 binding	1.96e-02	1.00e+00	5.661	1	1	19
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	2.06e-02	1.00e+00	5.587	1	1	20
GO:0014003	oligodendrocyte development	2.06e-02	1.00e+00	5.587	1	5	20
GO:0043393	regulation of protein binding	2.06e-02	1.00e+00	5.587	1	1	20
GO:0005730	nucleolus	2.14e-02	1.00e+00	1.551	5	66	1641
GO:0045787	positive regulation of cell cycle	2.26e-02	1.00e+00	5.450	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	2.26e-02	1.00e+00	5.450	1	4	22
GO:0008380	RNA splicing	2.28e-02	1.00e+00	3.076	2	22	228
GO:0030864	cortical actin cytoskeleton	2.37e-02	1.00e+00	5.386	1	1	23
GO:0035329	hippo signaling	2.67e-02	1.00e+00	5.209	1	5	26
GO:0006281	DNA repair	2.93e-02	1.00e+00	2.881	2	14	261
GO:0030901	midbrain development	2.98e-02	1.00e+00	5.051	1	1	29
GO:0003677	DNA binding	3.25e-02	1.00e+00	1.659	4	49	1218
GO:1903507	negative regulation of nucleic acid-templated transcription	3.28e-02	1.00e+00	4.909	1	2	32
GO:0030178	negative regulation of Wnt signaling pathway	3.58e-02	1.00e+00	4.780	1	4	35
GO:0035019	somatic stem cell maintenance	4.08e-02	1.00e+00	4.587	1	6	40
GO:0050885	neuromuscular process controlling balance	4.08e-02	1.00e+00	4.587	1	2	40
GO:0031124	mRNA 3'-end processing	4.28e-02	1.00e+00	4.517	1	2	42
GO:0003682	chromatin binding	4.43e-02	1.00e+00	2.556	2	19	327
GO:0050830	defense response to Gram-positive bacterium	4.58e-02	1.00e+00	4.417	1	3	45
GO:0006369	termination of RNA polymerase II transcription	4.58e-02	1.00e+00	4.417	1	2	45
GO:0030900	forebrain development	4.98e-02	1.00e+00	4.294	1	1	49
GO:0009611	response to wounding	5.28e-02	1.00e+00	4.209	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	5.38e-02	1.00e+00	4.181	1	5	53
GO:0008203	cholesterol metabolic process	5.77e-02	1.00e+00	4.076	1	2	57
GO:0008013	beta-catenin binding	6.06e-02	1.00e+00	4.002	1	9	60
GO:0006406	mRNA export from nucleus	6.16e-02	1.00e+00	3.978	1	4	61
GO:0004867	serine-type endopeptidase inhibitor activity	6.36e-02	1.00e+00	3.932	1	3	63
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	6.36e-02	1.00e+00	3.932	1	4	63
GO:0000151	ubiquitin ligase complex	6.36e-02	1.00e+00	3.932	1	1	63
GO:0010468	regulation of gene expression	6.85e-02	1.00e+00	3.822	1	2	68
GO:0007626	locomotory behavior	7.14e-02	1.00e+00	3.759	1	2	71
GO:0003729	mRNA binding	7.24e-02	1.00e+00	3.739	1	4	72
GO:0001843	neural tube closure	7.43e-02	1.00e+00	3.700	1	2	74
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	7.43e-02	1.00e+00	3.700	1	4	74
GO:0002020	protease binding	7.43e-02	1.00e+00	3.700	1	6	74
GO:0060070	canonical Wnt signaling pathway	7.53e-02	1.00e+00	3.680	1	4	75
GO:0009653	anatomical structure morphogenesis	8.30e-02	1.00e+00	3.534	1	2	83
GO:0006464	cellular protein modification process	8.39e-02	1.00e+00	3.517	1	4	84
GO:0050821	protein stabilization	8.78e-02	1.00e+00	3.450	1	3	88
GO:0042802	identical protein binding	8.85e-02	1.00e+00	1.990	2	19	484
GO:0044822	poly(A) RNA binding	9.20e-02	1.00e+00	1.450	3	50	1056
GO:0010951	negative regulation of endopeptidase activity	1.03e-01	1.00e+00	3.209	1	6	104
GO:0008201	heparin binding	1.20e-01	1.00e+00	2.978	1	1	122
GO:0006511	ubiquitin-dependent protein catabolic process	1.23e-01	1.00e+00	2.932	1	5	126
GO:0007507	heart development	1.35e-01	1.00e+00	2.790	1	7	139
GO:0010628	positive regulation of gene expression	1.42e-01	1.00e+00	2.719	1	7	146
GO:0006974	cellular response to DNA damage stimulus	1.46e-01	1.00e+00	2.671	1	7	151
GO:0043005	neuron projection	1.51e-01	1.00e+00	2.615	1	3	157
GO:0008022	protein C-terminus binding	1.55e-01	1.00e+00	2.578	1	8	161
GO:0000398	mRNA splicing, via spliceosome	1.58e-01	1.00e+00	2.552	1	15	164
GO:0003700	sequence-specific DNA binding transcription factor activity	1.63e-01	1.00e+00	1.460	2	39	699
GO:0007049	cell cycle	1.67e-01	1.00e+00	2.466	1	6	174
GO:0003714	transcription corepressor activity	1.70e-01	1.00e+00	2.433	1	11	178
GO:0019904	protein domain specific binding	1.71e-01	1.00e+00	2.425	1	8	179
GO:0005737	cytoplasm	1.74e-01	1.00e+00	0.615	6	124	3767
GO:0032403	protein complex binding	1.74e-01	1.00e+00	2.393	1	6	183
GO:0016874	ligase activity	2.01e-01	1.00e+00	2.168	1	4	214
GO:0008134	transcription factor binding	2.24e-01	1.00e+00	1.990	1	18	242
GO:0043025	neuronal cell body	2.27e-01	1.00e+00	1.973	1	9	245
GO:0004842	ubiquitin-protein transferase activity	2.35e-01	1.00e+00	1.915	1	5	255
GO:0000166	nucleotide binding	2.38e-01	1.00e+00	1.892	1	13	259
GO:0003779	actin binding	2.44e-01	1.00e+00	1.854	1	10	266
GO:0006954	inflammatory response	2.53e-01	1.00e+00	1.795	1	6	277
GO:0030198	extracellular matrix organization	2.57e-01	1.00e+00	1.765	1	6	283
GO:0007186	G-protein coupled receptor signaling pathway	2.62e-01	1.00e+00	1.734	1	1	289
GO:0008283	cell proliferation	2.92e-01	1.00e+00	1.552	1	14	328
GO:0003723	RNA binding	3.02e-01	1.00e+00	1.491	1	18	342
GO:0043565	sequence-specific DNA binding	3.05e-01	1.00e+00	1.475	1	11	346
GO:0005925	focal adhesion	3.20e-01	1.00e+00	1.393	1	9	366
GO:0043066	negative regulation of apoptotic process	3.61e-01	1.00e+00	1.181	1	16	424
GO:0006351	transcription, DNA-templated	4.52e-01	1.00e+00	0.411	2	57	1446
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	4.54e-01	1.00e+00	0.754	1	37	570
GO:0042803	protein homodimerization activity	4.69e-01	1.00e+00	0.692	1	19	595
GO:0005739	mitochondrion	6.59e-01	1.00e+00	-0.054	1	23	998
GO:0008270	zinc ion binding	6.59e-01	1.00e+00	-0.052	1	27	997
GO:0005829	cytosol	7.61e-01	1.00e+00	-0.376	2	86	2496
GO:0005886	plasma membrane	7.79e-01	1.00e+00	-0.425	2	49	2582
GO:0016021	integral component of membrane	8.91e-01	1.00e+00	-1.044	1	17	1982
GO:0070062	extracellular vesicular exosome	9.35e-01	1.00e+00	-1.320	1	57	2400

chia-Fav

int-snw-29079

Statistics

Genes (15)

Interactions (22)

Related GO terms (155)