int-snw-221241

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.928	1.59e-16	1.51e-04	1.49e-03

chia-screen-data-Fav-int-snw-221241 subnetwork

Genes (16)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
LARS	51520	14	-2.574	3.157	105	Yes	Yes
EMX1	2016	4	-2.369	3.216	19	Yes	-
MED19	219541	30	-2.657	3.449	115	Yes	-
[ LINC00305 ]	221241	1	-1.311	2.928	1	-	-
POLR2D	5433	3	-1.998	3.216	36	-	-
MED28	80306	16	-2.404	3.216	80	Yes	-
MED13L	23389	12	-2.550	3.159	21	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
KDM4B	23030	5	-3.892	3.216	5	Yes	-
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
POLR2E	5434	4	-2.037	3.157	115	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
RBBP6	5930	1	-2.045	2.928	43	Yes	-

Interactions (20)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
POLR2E	5434	MED28	80306	pp	--	int.I2D: BioGrid
MED28	80306	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
EMX1	2016	KDM4B	23030	pp	--	int.I2D: BioGrid_Mouse
YAP1	10413	MED28	80306	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
POLR2D	5433	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HCFC1	3054	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
POLR2E	5434	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
POLR2D	5433	POLR2E	5434	pp	--	int.I2D: BCI, BioGrid, BIND, HPRD; int.Ravasi: -; int.HPRD: in vitro
POLR2D	5433	MED28	80306	pp	--	int.I2D: BioGrid
POLR2D	5433	RBBP6	5930	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
PSMD2	5708	LARS	51520	pp	--	int.I2D: BioGrid_Yeast
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
RBBP6	5930	LINC00305	221241	pp	--	int.HPRD: yeast 2-hybrid
EMX1	2016	POLR2D	5433	pp	--	int.I2D: BioGrid; int.Ravasi: -
MED13L	23389	MED28	80306	pp	--	int.I2D: BioGrid
MED13L	23389	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
POLR2E	5434	LARS	51520	pp	--	int.I2D: YeastLow

Related GO terms (173)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006366	transcription from RNA polymerase II promoter	1.52e-07	2.19e-03	3.913	7	30	419
GO:0016592	mediator complex	7.17e-06	1.03e-01	6.272	3	10	35
GO:0010467	gene expression	5.23e-05	7.54e-01	3.015	6	45	669
GO:0005654	nucleoplasm	8.21e-05	1.00e+00	2.544	7	64	1082
GO:0008380	RNA splicing	9.53e-05	1.00e+00	3.983	4	22	228
GO:0005665	DNA-directed RNA polymerase II, core complex	1.37e-04	1.00e+00	6.816	2	4	16
GO:0003899	DNA-directed RNA polymerase activity	3.41e-04	1.00e+00	6.172	2	3	25
GO:0006355	regulation of transcription, DNA-templated	4.71e-04	1.00e+00	2.440	6	43	997
GO:0006370	7-methylguanosine mRNA capping	4.93e-04	1.00e+00	5.909	2	5	30
GO:0001104	RNA polymerase II transcription cofactor activity	5.97e-04	1.00e+00	5.772	2	8	33
GO:0000398	mRNA splicing, via spliceosome	7.25e-04	1.00e+00	4.043	3	15	164
GO:0006367	transcription initiation from RNA polymerase II promoter	1.01e-03	1.00e+00	3.877	3	22	184
GO:0050434	positive regulation of viral transcription	1.06e-03	1.00e+00	5.357	2	5	44
GO:0060795	cell fate commitment involved in formation of primary germ layer	1.11e-03	1.00e+00	9.816	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	1.11e-03	1.00e+00	9.816	1	1	1
GO:0034402	recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex	1.11e-03	1.00e+00	9.816	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	1.11e-03	1.00e+00	9.816	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	1.11e-03	1.00e+00	9.816	1	1	1
GO:0006283	transcription-coupled nucleotide-excision repair	1.16e-03	1.00e+00	5.293	2	4	46
GO:0006429	leucyl-tRNA aminoacylation	2.22e-03	1.00e+00	8.816	1	1	2
GO:0060242	contact inhibition	2.22e-03	1.00e+00	8.816	1	1	2
GO:0031990	mRNA export from nucleus in response to heat stress	2.22e-03	1.00e+00	8.816	1	2	2
GO:0019046	release from viral latency	2.22e-03	1.00e+00	8.816	1	2	2
GO:0009786	regulation of asymmetric cell division	2.22e-03	1.00e+00	8.816	1	1	2
GO:0004823	leucine-tRNA ligase activity	2.22e-03	1.00e+00	8.816	1	1	2
GO:0006368	transcription elongation from RNA polymerase II promoter	2.45e-03	1.00e+00	4.750	2	6	67
GO:0005634	nucleus	2.50e-03	1.00e+00	1.121	11	159	4559
GO:0006289	nucleotide-excision repair	2.52e-03	1.00e+00	4.729	2	5	68
GO:0060913	cardiac cell fate determination	3.32e-03	1.00e+00	8.231	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	3.32e-03	1.00e+00	8.231	1	1	3
GO:0051151	negative regulation of smooth muscle cell differentiation	4.43e-03	1.00e+00	7.816	1	1	4
GO:0070461	SAGA-type complex	5.54e-03	1.00e+00	7.494	1	2	5
GO:0001714	endodermal cell fate specification	5.54e-03	1.00e+00	7.494	1	1	5
GO:0021796	cerebral cortex regionalization	5.54e-03	1.00e+00	7.494	1	1	5
GO:1990138	neuron projection extension	5.54e-03	1.00e+00	7.494	1	1	5
GO:0002161	aminoacyl-tRNA editing activity	7.74e-03	1.00e+00	7.009	1	2	7
GO:0001055	RNA polymerase II activity	8.84e-03	1.00e+00	6.816	1	3	8
GO:0070688	MLL5-L complex	8.84e-03	1.00e+00	6.816	1	1	8
GO:0043254	regulation of protein complex assembly	8.84e-03	1.00e+00	6.816	1	1	8
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	9.94e-03	1.00e+00	6.646	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	9.94e-03	1.00e+00	6.646	1	5	9
GO:0048188	Set1C/COMPASS complex	9.94e-03	1.00e+00	6.646	1	4	9
GO:0006450	regulation of translational fidelity	9.94e-03	1.00e+00	6.646	1	2	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	9.94e-03	1.00e+00	6.646	1	5	9
GO:0021895	cerebral cortex neuron differentiation	9.94e-03	1.00e+00	6.646	1	1	9
GO:0035413	positive regulation of catenin import into nucleus	1.10e-02	1.00e+00	6.494	1	2	10
GO:0061053	somite development	1.10e-02	1.00e+00	6.494	1	1	10
GO:0001054	RNA polymerase I activity	1.21e-02	1.00e+00	6.357	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	1.21e-02	1.00e+00	6.357	1	4	11
GO:0005736	DNA-directed RNA polymerase I complex	1.32e-02	1.00e+00	6.231	1	3	12
GO:0005838	proteasome regulatory particle	1.32e-02	1.00e+00	6.231	1	1	12
GO:0035198	miRNA binding	1.32e-02	1.00e+00	6.231	1	1	12
GO:0045948	positive regulation of translational initiation	1.32e-02	1.00e+00	6.231	1	1	12
GO:0071480	cellular response to gamma radiation	1.43e-02	1.00e+00	6.116	1	1	13
GO:0051213	dioxygenase activity	1.43e-02	1.00e+00	6.116	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	1.43e-02	1.00e+00	6.116	1	2	13
GO:0030234	enzyme regulator activity	1.43e-02	1.00e+00	6.116	1	2	13
GO:0044212	transcription regulatory region DNA binding	1.45e-02	1.00e+00	3.424	2	17	168
GO:0016607	nuclear speck	1.52e-02	1.00e+00	3.390	2	12	172
GO:0005685	U1 snRNP	1.54e-02	1.00e+00	6.009	1	1	14
GO:0048568	embryonic organ development	1.54e-02	1.00e+00	6.009	1	1	14
GO:0043981	histone H4-K5 acetylation	1.65e-02	1.00e+00	5.909	1	5	15
GO:0031369	translation initiation factor binding	1.65e-02	1.00e+00	5.909	1	2	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	1.65e-02	1.00e+00	5.909	1	3	15
GO:0001824	blastocyst development	1.65e-02	1.00e+00	5.909	1	2	15
GO:0043982	histone H4-K8 acetylation	1.65e-02	1.00e+00	5.909	1	5	15
GO:0048854	brain morphogenesis	1.65e-02	1.00e+00	5.909	1	2	15
GO:0006376	mRNA splice site selection	1.65e-02	1.00e+00	5.909	1	1	15
GO:0043274	phospholipase binding	1.76e-02	1.00e+00	5.816	1	1	16
GO:0042176	regulation of protein catabolic process	1.76e-02	1.00e+00	5.816	1	2	16
GO:0001056	RNA polymerase III activity	1.76e-02	1.00e+00	5.816	1	3	16
GO:0005666	DNA-directed RNA polymerase III complex	1.87e-02	1.00e+00	5.729	1	3	17
GO:0022624	proteasome accessory complex	1.87e-02	1.00e+00	5.729	1	1	17
GO:0016032	viral process	1.97e-02	1.00e+00	2.340	3	26	534
GO:0006386	termination of RNA polymerase III transcription	1.98e-02	1.00e+00	5.646	1	3	18
GO:0006385	transcription elongation from RNA polymerase III promoter	1.98e-02	1.00e+00	5.646	1	3	18
GO:0001701	in utero embryonic development	2.04e-02	1.00e+00	3.165	2	8	201
GO:0043984	histone H4-K16 acetylation	2.09e-02	1.00e+00	5.568	1	5	19
GO:0000123	histone acetyltransferase complex	2.31e-02	1.00e+00	5.424	1	6	21
GO:0045787	positive regulation of cell cycle	2.41e-02	1.00e+00	5.357	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	2.41e-02	1.00e+00	5.357	1	4	22
GO:0030864	cortical actin cytoskeleton	2.52e-02	1.00e+00	5.293	1	1	23
GO:0044822	poly(A) RNA binding	2.56e-02	1.00e+00	1.772	4	50	1056
GO:0005515	protein binding	2.71e-02	1.00e+00	0.719	11	198	6024
GO:0003713	transcription coactivator activity	2.77e-02	1.00e+00	2.927	2	24	237
GO:0035329	hippo signaling	2.85e-02	1.00e+00	5.116	1	5	26
GO:0071339	MLL1 complex	2.96e-02	1.00e+00	5.061	1	6	27
GO:0003727	single-stranded RNA binding	3.06e-02	1.00e+00	5.009	1	2	28
GO:0000166	nucleotide binding	3.27e-02	1.00e+00	2.799	2	13	259
GO:0006360	transcription from RNA polymerase I promoter	3.28e-02	1.00e+00	4.909	1	3	30
GO:0006281	DNA repair	3.31e-02	1.00e+00	2.788	2	14	261
GO:0006357	regulation of transcription from RNA polymerase II promoter	3.38e-02	1.00e+00	2.772	2	23	264
GO:1903507	negative regulation of nucleic acid-templated transcription	3.49e-02	1.00e+00	4.816	1	2	32
GO:0006383	transcription from RNA polymerase III promoter	4.24e-02	1.00e+00	4.531	1	3	39
GO:0035019	somatic stem cell maintenance	4.35e-02	1.00e+00	4.494	1	6	40
GO:0006418	tRNA aminoacylation for protein translation	4.56e-02	1.00e+00	4.424	1	3	42
GO:0031124	mRNA 3'-end processing	4.56e-02	1.00e+00	4.424	1	2	42
GO:0006369	termination of RNA polymerase II transcription	4.88e-02	1.00e+00	4.324	1	2	45
GO:0019827	stem cell maintenance	5.09e-02	1.00e+00	4.261	1	7	47
GO:0006521	regulation of cellular amino acid metabolic process	5.41e-02	1.00e+00	4.172	1	1	50
GO:0043565	sequence-specific DNA binding	5.52e-02	1.00e+00	2.381	2	11	346
GO:0009611	response to wounding	5.62e-02	1.00e+00	4.116	1	5	52
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	5.72e-02	1.00e+00	4.088	1	4	53
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	5.83e-02	1.00e+00	4.061	1	3	54
GO:0000932	cytoplasmic mRNA processing body	5.83e-02	1.00e+00	4.061	1	4	54
GO:0005925	focal adhesion	6.10e-02	1.00e+00	2.300	2	9	366
GO:0000502	proteasome complex	6.25e-02	1.00e+00	3.958	1	3	58
GO:0032481	positive regulation of type I interferon production	6.56e-02	1.00e+00	3.885	1	6	61
GO:0006406	mRNA export from nucleus	6.56e-02	1.00e+00	3.885	1	4	61
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	6.87e-02	1.00e+00	3.816	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.98e-02	1.00e+00	3.794	1	2	65
GO:0035264	multicellular organism growth	7.18e-02	1.00e+00	3.750	1	2	67
GO:0010468	regulation of gene expression	7.29e-02	1.00e+00	3.729	1	2	68
GO:0003697	single-stranded DNA binding	7.29e-02	1.00e+00	3.729	1	5	68
GO:0005694	chromosome	7.49e-02	1.00e+00	3.687	1	2	70
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.49e-02	1.00e+00	3.687	1	2	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	7.70e-02	1.00e+00	3.646	1	1	72
GO:0003729	mRNA binding	7.70e-02	1.00e+00	3.646	1	4	72
GO:0009791	post-embryonic development	7.80e-02	1.00e+00	3.626	1	3	73
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	7.90e-02	1.00e+00	3.607	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.90e-02	1.00e+00	3.607	1	2	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	8.01e-02	1.00e+00	3.587	1	1	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	8.42e-02	1.00e+00	3.512	1	2	79
GO:0009653	anatomical structure morphogenesis	8.82e-02	1.00e+00	3.441	1	2	83
GO:0050821	protein stabilization	9.33e-02	1.00e+00	3.357	1	3	88
GO:0005737	cytoplasm	9.70e-02	1.00e+00	0.744	7	124	3767
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	9.74e-02	1.00e+00	3.293	1	1	92
GO:0016568	chromatin modification	1.03e-01	1.00e+00	3.201	1	4	98
GO:0005815	microtubule organizing center	1.14e-01	1.00e+00	3.048	1	3	109
GO:0000209	protein polyubiquitination	1.21e-01	1.00e+00	2.958	1	3	116
GO:0006325	chromatin organization	1.23e-01	1.00e+00	2.933	1	12	118
GO:0005829	cytosol	1.28e-01	1.00e+00	0.853	5	86	2496
GO:0003677	DNA binding	1.48e-01	1.00e+00	1.151	3	49	1218
GO:0010628	positive regulation of gene expression	1.50e-01	1.00e+00	2.626	1	7	146
GO:0000082	G1/S transition of mitotic cell cycle	1.53e-01	1.00e+00	2.597	1	3	149
GO:0042981	regulation of apoptotic process	1.54e-01	1.00e+00	2.587	1	4	150
GO:0006974	cellular response to DNA damage stimulus	1.55e-01	1.00e+00	2.578	1	7	151
GO:0034641	cellular nitrogen compound metabolic process	1.74e-01	1.00e+00	2.398	1	2	171
GO:0007049	cell cycle	1.77e-01	1.00e+00	2.373	1	6	174
GO:0005667	transcription factor complex	1.78e-01	1.00e+00	2.365	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.80e-01	1.00e+00	2.340	1	5	178
GO:0003714	transcription corepressor activity	1.80e-01	1.00e+00	2.340	1	11	178
GO:0003700	sequence-specific DNA binding transcription factor activity	1.80e-01	1.00e+00	1.367	2	39	699
GO:0016874	ligase activity	2.13e-01	1.00e+00	2.075	1	4	214
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	2.17e-01	1.00e+00	1.192	2	41	789
GO:0016071	mRNA metabolic process	2.21e-01	1.00e+00	2.015	1	8	223
GO:0008134	transcription factor binding	2.37e-01	1.00e+00	1.897	1	18	242
GO:0043025	neuronal cell body	2.40e-01	1.00e+00	1.879	1	9	245
GO:0016070	RNA metabolic process	2.42e-01	1.00e+00	1.868	1	8	247
GO:0004842	ubiquitin-protein transferase activity	2.48e-01	1.00e+00	1.822	1	5	255
GO:0003779	actin binding	2.58e-01	1.00e+00	1.761	1	10	266
GO:0005730	nucleolus	2.71e-01	1.00e+00	0.721	3	66	1641
GO:0042493	response to drug	2.73e-01	1.00e+00	1.666	1	6	284
GO:0016020	membrane	2.84e-01	1.00e+00	0.686	3	46	1681
GO:0008270	zinc ion binding	3.04e-01	1.00e+00	0.855	2	27	997
GO:0003682	chromatin binding	3.07e-01	1.00e+00	1.463	1	19	327
GO:0008283	cell proliferation	3.08e-01	1.00e+00	1.459	1	14	328
GO:0030054	cell junction	3.14e-01	1.00e+00	1.424	1	5	336
GO:0003723	RNA binding	3.19e-01	1.00e+00	1.398	1	18	342
GO:0000278	mitotic cell cycle	3.56e-01	1.00e+00	1.205	1	15	391
GO:0055114	oxidation-reduction process	3.77e-01	1.00e+00	1.102	1	10	420
GO:0043066	negative regulation of apoptotic process	3.80e-01	1.00e+00	1.088	1	16	424
GO:0042802	identical protein binding	4.21e-01	1.00e+00	0.897	1	19	484
GO:0006915	apoptotic process	4.66e-01	1.00e+00	0.700	1	12	555
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	4.76e-01	1.00e+00	0.661	1	37	570
GO:0006351	transcription, DNA-templated	4.87e-01	1.00e+00	0.318	2	57	1446
GO:0045087	innate immune response	4.91e-01	1.00e+00	0.597	1	15	596
GO:0005576	extracellular region	6.61e-01	1.00e+00	-0.063	1	13	942
GO:0005739	mitochondrion	6.83e-01	1.00e+00	-0.147	1	23	998
GO:0044281	small molecule metabolic process	7.54e-01	1.00e+00	-0.426	1	20	1211
GO:0005524	ATP binding	7.79e-01	1.00e+00	-0.526	1	31	1298
GO:0070062	extracellular vesicular exosome	9.46e-01	1.00e+00	-1.413	1	57	2400
GO:0005886	plasma membrane	9.57e-01	1.00e+00	-1.518	1	49	2582

chia-Fav

int-snw-221241

Statistics

Genes (16)

Interactions (20)

Related GO terms (173)