int-snw-2146

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.904	2.97e-16	2.07e-04	1.86e-03

chia-screen-data-Fav-int-snw-2146 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
MED13L	23389	12	-2.550	3.159	21	Yes	-
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
YY1	7528	24	-2.572	3.120	114	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
PHB2	11331	5	-2.236	2.994	140	Yes	-
SUZ12	23512	2	-1.792	2.904	42	-	-
[ EZH2 ]	2146	2	-1.631	2.904	105	-	-

Interactions (8)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
EZH2	2146	POU5F1	5460	pp	--	int.I2D: BioGrid
NFRKB	4798	YY1	7528	pp	--	int.I2D: BioGrid
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
EZH2	2146	YY1	7528	pp	--	int.I2D: BioGrid, BCI
EZH2	2146	PHB2	11331	pp	--	int.I2D: BioGrid
EZH2	2146	MED13L	23389	pp	--	int.I2D: BioGrid_Fly
PSMD2	5708	PHB2	11331	pp	--	int.I2D: IntAct_Yeast
EZH2	2146	SUZ12	23512	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, BioGrid_Fly, BioGrid_Mouse, IntAct_Mouse, BCI, HPRD, IntAct_Fly; int.Ravasi: -; int.HPRD: in vivo

Related GO terms (138)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0042054	histone methyltransferase activity	7.53e-06	1.09e-01	8.816	2	3	8
GO:0031011	Ino80 complex	2.44e-05	3.52e-01	8.009	2	6	14
GO:0035098	ESC/E(Z) complex	2.82e-05	4.06e-01	7.909	2	3	15
GO:0014013	regulation of gliogenesis	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060795	cell fate commitment involved in formation of primary germ layer	5.55e-04	1.00e+00	10.816	1	1	1
GO:0045605	negative regulation of epidermal cell differentiation	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	5.55e-04	1.00e+00	10.816	1	1	1
GO:0003723	RNA binding	6.77e-04	1.00e+00	3.983	3	18	342
GO:0043565	sequence-specific DNA binding	7.01e-04	1.00e+00	3.966	3	11	346
GO:0016363	nuclear matrix	1.08e-03	1.00e+00	5.308	2	6	91
GO:0034696	response to prostaglandin F	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006403	RNA localization	1.11e-03	1.00e+00	9.816	1	1	2
GO:0009786	regulation of asymmetric cell division	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006366	transcription from RNA polymerase II promoter	1.22e-03	1.00e+00	3.690	3	30	419
GO:0051154	negative regulation of striated muscle cell differentiation	1.66e-03	1.00e+00	9.231	1	1	3
GO:0070314	G1 to G0 transition	1.66e-03	1.00e+00	9.231	1	1	3
GO:0060913	cardiac cell fate determination	1.66e-03	1.00e+00	9.231	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.66e-03	1.00e+00	9.231	1	1	3
GO:0005654	nucleoplasm	1.73e-03	1.00e+00	2.737	4	64	1082
GO:0046976	histone methyltransferase activity (H3-K27 specific)	2.22e-03	1.00e+00	8.816	1	1	4
GO:0070734	histone H3-K27 methylation	2.22e-03	1.00e+00	8.816	1	1	4
GO:0003677	DNA binding	2.68e-03	1.00e+00	2.566	4	49	1218
GO:0001714	endodermal cell fate specification	2.77e-03	1.00e+00	8.494	1	1	5
GO:0071168	protein localization to chromatin	2.77e-03	1.00e+00	8.494	1	1	5
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	2.77e-03	1.00e+00	8.494	1	1	5
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	2.96e-03	1.00e+00	3.246	3	37	570
GO:0021695	cerebellar cortex development	3.32e-03	1.00e+00	8.231	1	1	6
GO:0060744	mammary gland branching involved in thelarche	3.32e-03	1.00e+00	8.231	1	2	6
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	3.32e-03	1.00e+00	8.231	1	2	6
GO:0044212	transcription regulatory region DNA binding	3.61e-03	1.00e+00	4.424	2	17	168
GO:0016574	histone ubiquitination	3.88e-03	1.00e+00	8.009	1	1	7
GO:0001739	sex chromatin	3.88e-03	1.00e+00	8.009	1	1	7
GO:0045814	negative regulation of gene expression, epigenetic	3.88e-03	1.00e+00	8.009	1	2	7
GO:0005667	transcription factor complex	3.91e-03	1.00e+00	4.365	2	17	175
GO:0048387	negative regulation of retinoic acid receptor signaling pathway	4.43e-03	1.00e+00	7.816	1	2	8
GO:0010225	response to UV-C	4.98e-03	1.00e+00	7.646	1	2	9
GO:0000400	four-way junction DNA binding	4.98e-03	1.00e+00	7.646	1	1	9
GO:0006351	transcription, DNA-templated	5.06e-03	1.00e+00	2.318	4	57	1446
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	5.53e-03	1.00e+00	7.494	1	1	10
GO:0035413	positive regulation of catenin import into nucleus	5.53e-03	1.00e+00	7.494	1	2	10
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	5.53e-03	1.00e+00	7.494	1	2	10
GO:0045120	pronucleus	6.09e-03	1.00e+00	7.357	1	2	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.09e-03	1.00e+00	7.357	1	4	11
GO:0005838	proteasome regulatory particle	6.64e-03	1.00e+00	7.231	1	1	12
GO:0035198	miRNA binding	6.64e-03	1.00e+00	7.231	1	1	12
GO:0042789	mRNA transcription from RNA polymerase II promoter	7.19e-03	1.00e+00	7.116	1	2	13
GO:0030234	enzyme regulator activity	7.19e-03	1.00e+00	7.116	1	2	13
GO:0001824	blastocyst development	8.29e-03	1.00e+00	6.909	1	2	15
GO:0060749	mammary gland alveolus development	8.29e-03	1.00e+00	6.909	1	2	15
GO:0016571	histone methylation	8.29e-03	1.00e+00	6.909	1	2	15
GO:0006357	regulation of transcription from RNA polymerase II promoter	8.69e-03	1.00e+00	3.772	2	23	264
GO:0042176	regulation of protein catabolic process	8.84e-03	1.00e+00	6.816	1	2	16
GO:0051276	chromosome organization	8.84e-03	1.00e+00	6.816	1	2	16
GO:0048593	camera-type eye morphogenesis	8.84e-03	1.00e+00	6.816	1	1	16
GO:0022624	proteasome accessory complex	9.39e-03	1.00e+00	6.729	1	1	17
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	1.10e-02	1.00e+00	6.494	1	1	20
GO:0045596	negative regulation of cell differentiation	1.10e-02	1.00e+00	6.494	1	1	20
GO:0005515	protein binding	1.12e-02	1.00e+00	1.067	7	198	6024
GO:0006306	DNA methylation	1.21e-02	1.00e+00	6.357	1	1	22
GO:0003682	chromatin binding	1.31e-02	1.00e+00	3.463	2	19	327
GO:0010718	positive regulation of epithelial to mesenchymal transition	1.38e-02	1.00e+00	6.172	1	4	25
GO:0031519	PcG protein complex	1.38e-02	1.00e+00	6.172	1	1	25
GO:0006355	regulation of transcription, DNA-templated	1.42e-02	1.00e+00	2.440	3	43	997
GO:0071902	positive regulation of protein serine/threonine kinase activity	1.43e-02	1.00e+00	6.116	1	2	26
GO:0030331	estrogen receptor binding	1.49e-02	1.00e+00	6.061	1	2	27
GO:0005634	nucleus	1.49e-02	1.00e+00	1.247	6	159	4559
GO:0034644	cellular response to UV	1.65e-02	1.00e+00	5.909	1	1	30
GO:0032320	positive regulation of Ras GTPase activity	1.76e-02	1.00e+00	5.816	1	1	32
GO:0001104	RNA polymerase II transcription cofactor activity	1.82e-02	1.00e+00	5.772	1	8	33
GO:0016592	mediator complex	1.93e-02	1.00e+00	5.687	1	10	35
GO:0042752	regulation of circadian rhythm	2.03e-02	1.00e+00	5.607	1	3	37
GO:0045892	negative regulation of transcription, DNA-templated	2.04e-02	1.00e+00	3.126	2	24	413
GO:0031490	chromatin DNA binding	2.09e-02	1.00e+00	5.568	1	2	38
GO:0035019	somatic stem cell maintenance	2.20e-02	1.00e+00	5.494	1	6	40
GO:0070301	cellular response to hydrogen peroxide	2.25e-02	1.00e+00	5.459	1	2	41
GO:0001047	core promoter binding	2.47e-02	1.00e+00	5.324	1	5	45
GO:0048511	rhythmic process	2.47e-02	1.00e+00	5.324	1	4	45
GO:0035064	methylated histone binding	2.52e-02	1.00e+00	5.293	1	2	46
GO:0043406	positive regulation of MAP kinase activity	2.52e-02	1.00e+00	5.293	1	2	46
GO:0006521	regulation of cellular amino acid metabolic process	2.74e-02	1.00e+00	5.172	1	1	50
GO:0009611	response to wounding	2.85e-02	1.00e+00	5.116	1	5	52
GO:0000724	double-strand break repair via homologous recombination	3.01e-02	1.00e+00	5.035	1	2	55
GO:0000502	proteasome complex	3.17e-02	1.00e+00	4.958	1	3	58
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	3.23e-02	1.00e+00	4.933	1	5	59
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	3.50e-02	1.00e+00	4.816	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.55e-02	1.00e+00	4.794	1	2	65
GO:0006310	DNA recombination	3.55e-02	1.00e+00	4.794	1	7	65
GO:0010468	regulation of gene expression	3.71e-02	1.00e+00	4.729	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.82e-02	1.00e+00	4.687	1	2	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	3.93e-02	1.00e+00	4.646	1	1	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.03e-02	1.00e+00	4.607	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.03e-02	1.00e+00	4.607	1	2	74
GO:0002020	protease binding	4.03e-02	1.00e+00	4.607	1	6	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	4.09e-02	1.00e+00	4.587	1	1	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	4.30e-02	1.00e+00	4.512	1	2	79
GO:0009653	anatomical structure morphogenesis	4.51e-02	1.00e+00	4.441	1	2	83
GO:0009952	anterior/posterior pattern specification	4.51e-02	1.00e+00	4.441	1	4	83
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	4.99e-02	1.00e+00	4.293	1	1	92
GO:0003700	sequence-specific DNA binding transcription factor activity	5.41e-02	1.00e+00	2.367	2	39	699
GO:0042127	regulation of cell proliferation	5.89e-02	1.00e+00	4.048	1	4	109
GO:0000209	protein polyubiquitination	6.26e-02	1.00e+00	3.958	1	3	116
GO:0006325	chromatin organization	6.36e-02	1.00e+00	3.933	1	12	118
GO:0000790	nuclear chromatin	6.94e-02	1.00e+00	3.805	1	6	129
GO:0000082	G1/S transition of mitotic cell cycle	7.97e-02	1.00e+00	3.597	1	3	149
GO:0042981	regulation of apoptotic process	8.03e-02	1.00e+00	3.587	1	4	150
GO:0006974	cellular response to DNA damage stimulus	8.08e-02	1.00e+00	3.578	1	7	151
GO:0034641	cellular nitrogen compound metabolic process	9.10e-02	1.00e+00	3.398	1	2	171
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	5	178
GO:0003714	transcription corepressor activity	9.46e-02	1.00e+00	3.340	1	11	178
GO:0016071	mRNA metabolic process	1.17e-01	1.00e+00	3.015	1	8	223
GO:0003713	transcription coactivator activity	1.24e-01	1.00e+00	2.927	1	24	237
GO:0008134	transcription factor binding	1.27e-01	1.00e+00	2.897	1	18	242
GO:0016070	RNA metabolic process	1.29e-01	1.00e+00	2.868	1	8	247
GO:0007283	spermatogenesis	1.36e-01	1.00e+00	2.783	1	3	262
GO:0006281	DNA repair	1.36e-01	1.00e+00	2.788	1	14	261
GO:0005743	mitochondrial inner membrane	1.44e-01	1.00e+00	2.702	1	6	277
GO:0006954	inflammatory response	1.44e-01	1.00e+00	2.702	1	6	277
GO:0043234	protein complex	1.52e-01	1.00e+00	2.612	1	11	295
GO:0030154	cell differentiation	1.55e-01	1.00e+00	2.582	1	5	301
GO:0008284	positive regulation of cell proliferation	1.93e-01	1.00e+00	2.239	1	10	382
GO:0000278	mitotic cell cycle	1.97e-01	1.00e+00	2.205	1	15	391
GO:0043066	negative regulation of apoptotic process	2.12e-01	1.00e+00	2.088	1	16	424
GO:0005730	nucleolus	2.29e-01	1.00e+00	1.136	2	66	1641
GO:0016032	viral process	2.61e-01	1.00e+00	1.755	1	26	534
GO:0006915	apoptotic process	2.69e-01	1.00e+00	1.700	1	12	555
GO:0010467	gene expression	3.16e-01	1.00e+00	1.430	1	45	669
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.62e-01	1.00e+00	1.192	1	41	789
GO:0070062	extracellular vesicular exosome	3.95e-01	1.00e+00	0.587	2	57	2400
GO:0005829	cytosol	4.15e-01	1.00e+00	0.531	2	86	2496
GO:0008270	zinc ion binding	4.36e-01	1.00e+00	0.855	1	27	997
GO:0005739	mitochondrion	4.37e-01	1.00e+00	0.853	1	23	998
GO:0044822	poly(A) RNA binding	4.56e-01	1.00e+00	0.772	1	50	1056
GO:0044281	small molecule metabolic process	5.04e-01	1.00e+00	0.574	1	20	1211
GO:0046872	metal ion binding	5.32e-01	1.00e+00	0.464	1	29	1307
GO:0016020	membrane	6.29e-01	1.00e+00	0.101	1	46	1681
GO:0005737	cytoplasm	6.60e-01	1.00e+00	-0.063	2	124	3767

chia-Fav

int-snw-2146

Statistics

Genes (8)

Interactions (8)

Related GO terms (138)