int-snw-2033

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.120	9.71e-19	1.03e-05	2.21e-04

chia-screen-data-Fav-int-snw-2033 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
YAP1	10413	94	-4.256	3.538	53	Yes	-
HES6	55502	8	-2.557	3.120	11	Yes	Yes
[ EP300 ]	2033	22	-2.274	3.120	415	Yes	Yes
TCL1A	8115	8	-2.457	3.120	11	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
YY1	7528	24	-2.572	3.120	114	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes

Interactions (9)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
EP300	2033	YY1	7528	pp	--	int.I2D: BioGrid, BCI, HPRD; int.Transfac: -; int.Ravasi: -; int.HPRD: in vivo; int.DIP: MI:0218(physical interaction)
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
EP300	2033	HES6	55502	pp	--	int.I2D: IntAct
DDIT3	1649	EP300	2033	pp	--	int.Intact: MI:0915(physical association)
EP300	2033	HNRNPU	3192	pp	--	int.I2D: BioGrid, HPRD, BCI; int.HPRD: in vitro, in vivo
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
EP300	2033	TCL1A	8115	pp	--	int.I2D: INNATEDB
EP300	2033	YAP1	10413	pp	--	int.I2D: BioGrid

Related GO terms (205)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0044212	transcription regulatory region DNA binding	1.20e-06	1.73e-02	5.424	4	17	168
GO:0005667	transcription factor complex	1.41e-06	2.04e-02	5.365	4	17	175
GO:0008134	transcription factor binding	5.13e-06	7.40e-02	4.897	4	18	242
GO:0003677	DNA binding	8.65e-06	1.25e-01	3.151	6	49	1218
GO:0003700	sequence-specific DNA binding transcription factor activity	1.31e-05	1.88e-01	3.689	5	39	699
GO:0042789	mRNA transcription from RNA polymerase II promoter	2.09e-05	3.02e-01	8.116	2	2	13
GO:0006974	cellular response to DNA damage stimulus	6.06e-05	8.74e-01	5.163	3	7	151
GO:0006355	regulation of transcription, DNA-templated	7.34e-05	1.00e+00	3.177	5	43	997
GO:0003714	transcription corepressor activity	9.89e-05	1.00e+00	4.925	3	11	178
GO:0005654	nucleoplasm	1.09e-04	1.00e+00	3.059	5	64	1082
GO:0003713	transcription coactivator activity	2.31e-04	1.00e+00	4.512	3	24	237
GO:0060795	cell fate commitment involved in formation of primary germ layer	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060177	regulation of angiotensin metabolic process	5.55e-04	1.00e+00	10.816	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	5.55e-04	1.00e+00	10.816	1	1	1
GO:1901985	positive regulation of protein acetylation	5.55e-04	1.00e+00	10.816	1	1	1
GO:0043969	histone H2B acetylation	5.55e-04	1.00e+00	10.816	1	1	1
GO:2000629	negative regulation of miRNA metabolic process	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	5.55e-04	1.00e+00	10.816	1	1	1
GO:0034696	response to prostaglandin F	1.11e-03	1.00e+00	9.816	1	1	2
GO:0060242	contact inhibition	1.11e-03	1.00e+00	9.816	1	1	2
GO:0014737	positive regulation of muscle atrophy	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006403	RNA localization	1.11e-03	1.00e+00	9.816	1	1	2
GO:0009786	regulation of asymmetric cell division	1.11e-03	1.00e+00	9.816	1	1	2
GO:0090043	regulation of tubulin deacetylation	1.11e-03	1.00e+00	9.816	1	2	2
GO:0035984	cellular response to trichostatin A	1.11e-03	1.00e+00	9.816	1	1	2
GO:0071389	cellular response to mineralocorticoid stimulus	1.11e-03	1.00e+00	9.816	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.11e-03	1.00e+00	9.816	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.11e-03	1.00e+00	9.816	1	1	2
GO:0018076	N-terminal peptidyl-lysine acetylation	1.66e-03	1.00e+00	9.231	1	1	3
GO:0060913	cardiac cell fate determination	1.66e-03	1.00e+00	9.231	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.66e-03	1.00e+00	9.231	1	1	3
GO:0010560	positive regulation of glycoprotein biosynthetic process	1.66e-03	1.00e+00	9.231	1	1	3
GO:0005634	nucleus	1.82e-03	1.00e+00	1.469	7	159	4559
GO:0097157	pre-mRNA intronic binding	2.22e-03	1.00e+00	8.816	1	1	4
GO:0018393	internal peptidyl-lysine acetylation	2.22e-03	1.00e+00	8.816	1	1	4
GO:0001714	endodermal cell fate specification	2.77e-03	1.00e+00	8.494	1	1	5
GO:0065004	protein-DNA complex assembly	2.77e-03	1.00e+00	8.494	1	1	5
GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	2.77e-03	1.00e+00	8.494	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	2.77e-03	1.00e+00	8.494	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	2.77e-03	1.00e+00	8.494	1	2	5
GO:0060298	positive regulation of sarcomere organization	2.77e-03	1.00e+00	8.494	1	1	5
GO:0032025	response to cobalt ion	2.77e-03	1.00e+00	8.494	1	1	5
GO:0070937	CRD-mediated mRNA stability complex	3.32e-03	1.00e+00	8.231	1	3	6
GO:0006475	internal protein amino acid acetylation	3.88e-03	1.00e+00	8.009	1	1	7
GO:0001955	blood vessel maturation	4.43e-03	1.00e+00	7.816	1	1	8
GO:0060765	regulation of androgen receptor signaling pathway	4.98e-03	1.00e+00	7.646	1	1	9
GO:0010225	response to UV-C	4.98e-03	1.00e+00	7.646	1	2	9
GO:0006983	ER overload response	4.98e-03	1.00e+00	7.646	1	1	9
GO:0035259	glucocorticoid receptor binding	4.98e-03	1.00e+00	7.646	1	1	9
GO:0045793	positive regulation of cell size	4.98e-03	1.00e+00	7.646	1	2	9
GO:0000400	four-way junction DNA binding	4.98e-03	1.00e+00	7.646	1	1	9
GO:0035413	positive regulation of catenin import into nucleus	5.53e-03	1.00e+00	7.494	1	2	10
GO:0016407	acetyltransferase activity	5.53e-03	1.00e+00	7.494	1	2	10
GO:0043923	positive regulation by host of viral transcription	6.09e-03	1.00e+00	7.357	1	1	11
GO:0033160	positive regulation of protein import into nucleus, translocation	6.09e-03	1.00e+00	7.357	1	3	11
GO:0045662	negative regulation of myoblast differentiation	6.09e-03	1.00e+00	7.357	1	3	11
GO:0042975	peroxisome proliferator activated receptor binding	6.09e-03	1.00e+00	7.357	1	1	11
GO:0045120	pronucleus	6.09e-03	1.00e+00	7.357	1	2	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.09e-03	1.00e+00	7.357	1	4	11
GO:0035198	miRNA binding	6.64e-03	1.00e+00	7.231	1	1	12
GO:0007399	nervous system development	6.71e-03	1.00e+00	3.964	2	6	231
GO:0071480	cellular response to gamma radiation	7.19e-03	1.00e+00	7.116	1	1	13
GO:0051019	mitogen-activated protein kinase binding	7.19e-03	1.00e+00	7.116	1	2	13
GO:0016746	transferase activity, transferring acyl groups	7.19e-03	1.00e+00	7.116	1	1	13
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	7.42e-03	1.00e+00	2.777	3	41	789
GO:0070542	response to fatty acid	7.74e-03	1.00e+00	7.009	1	1	14
GO:0031011	Ino80 complex	7.74e-03	1.00e+00	7.009	1	6	14
GO:0032993	protein-DNA complex	7.74e-03	1.00e+00	7.009	1	2	14
GO:0001824	blastocyst development	8.29e-03	1.00e+00	6.909	1	2	15
GO:1990090	cellular response to nerve growth factor stimulus	8.29e-03	1.00e+00	6.909	1	1	15
GO:0006357	regulation of transcription from RNA polymerase II promoter	8.69e-03	1.00e+00	3.772	2	23	264
GO:0051276	chromosome organization	8.84e-03	1.00e+00	6.816	1	2	16
GO:0048593	camera-type eye morphogenesis	8.84e-03	1.00e+00	6.816	1	1	16
GO:0045773	positive regulation of axon extension	9.94e-03	1.00e+00	6.646	1	1	18
GO:0033613	activating transcription factor binding	9.94e-03	1.00e+00	6.646	1	3	18
GO:0035257	nuclear hormone receptor binding	1.05e-02	1.00e+00	6.568	1	1	19
GO:0071549	cellular response to dexamethasone stimulus	1.10e-02	1.00e+00	6.494	1	3	20
GO:0010942	positive regulation of cell death	1.10e-02	1.00e+00	6.494	1	1	20
GO:0032757	positive regulation of interleukin-8 production	1.10e-02	1.00e+00	6.494	1	1	20
GO:0005515	protein binding	1.12e-02	1.00e+00	1.067	7	198	6024
GO:0030154	cell differentiation	1.12e-02	1.00e+00	3.582	2	5	301
GO:0000123	histone acetyltransferase complex	1.16e-02	1.00e+00	6.424	1	6	21
GO:0032967	positive regulation of collagen biosynthetic process	1.16e-02	1.00e+00	6.424	1	3	21
GO:0045862	positive regulation of proteolysis	1.16e-02	1.00e+00	6.424	1	2	21
GO:0003823	antigen binding	1.21e-02	1.00e+00	6.357	1	2	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	2	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.27e-02	1.00e+00	6.293	1	1	23
GO:0043388	positive regulation of DNA binding	1.32e-02	1.00e+00	6.231	1	2	24
GO:0043425	bHLH transcription factor binding	1.32e-02	1.00e+00	6.231	1	1	24
GO:0051059	NF-kappaB binding	1.38e-02	1.00e+00	6.172	1	3	25
GO:0031519	PcG protein complex	1.38e-02	1.00e+00	6.172	1	1	25
GO:0035329	hippo signaling	1.43e-02	1.00e+00	6.116	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.43e-02	1.00e+00	6.116	1	1	26
GO:0003723	RNA binding	1.43e-02	1.00e+00	3.398	2	18	342
GO:0048565	digestive tract development	1.43e-02	1.00e+00	6.116	1	2	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.43e-02	1.00e+00	6.116	1	1	26
GO:0043565	sequence-specific DNA binding	1.46e-02	1.00e+00	3.381	2	11	346
GO:0034612	response to tumor necrosis factor	1.49e-02	1.00e+00	6.061	1	2	27
GO:0043967	histone H4 acetylation	1.49e-02	1.00e+00	6.061	1	1	27
GO:0050714	positive regulation of protein secretion	1.54e-02	1.00e+00	6.009	1	3	28
GO:0034644	cellular response to UV	1.65e-02	1.00e+00	5.909	1	1	30
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	1.65e-02	1.00e+00	5.909	1	1	30
GO:0042594	response to starvation	1.71e-02	1.00e+00	5.862	1	4	31
GO:0043491	protein kinase B signaling	1.76e-02	1.00e+00	5.816	1	2	32
GO:1903507	negative regulation of nucleic acid-templated transcription	1.76e-02	1.00e+00	5.816	1	2	32
GO:0071333	cellular response to glucose stimulus	1.82e-02	1.00e+00	5.772	1	1	33
GO:0001756	somitogenesis	1.82e-02	1.00e+00	5.772	1	1	33
GO:0001102	RNA polymerase II activating transcription factor binding	1.98e-02	1.00e+00	5.646	1	1	36
GO:0032092	positive regulation of protein binding	2.09e-02	1.00e+00	5.568	1	2	38
GO:0031490	chromatin DNA binding	2.09e-02	1.00e+00	5.568	1	2	38
GO:0050681	androgen receptor binding	2.09e-02	1.00e+00	5.568	1	1	38
GO:0035019	somatic stem cell maintenance	2.20e-02	1.00e+00	5.494	1	6	40
GO:0007519	skeletal muscle tissue development	2.20e-02	1.00e+00	5.494	1	2	40
GO:0046332	SMAD binding	2.20e-02	1.00e+00	5.494	1	2	40
GO:0071320	cellular response to cAMP	2.20e-02	1.00e+00	5.494	1	1	40
GO:0070301	cellular response to hydrogen peroxide	2.25e-02	1.00e+00	5.459	1	2	41
GO:0004402	histone acetyltransferase activity	2.36e-02	1.00e+00	5.390	1	6	43
GO:0045727	positive regulation of translation	2.42e-02	1.00e+00	5.357	1	2	44
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	2.42e-02	1.00e+00	5.357	1	4	44
GO:0003712	transcription cofactor activity	2.42e-02	1.00e+00	5.357	1	8	44
GO:0043966	histone H3 acetylation	2.47e-02	1.00e+00	5.324	1	5	45
GO:0001047	core promoter binding	2.47e-02	1.00e+00	5.324	1	5	45
GO:0043525	positive regulation of neuron apoptotic process	2.52e-02	1.00e+00	5.293	1	4	46
GO:0019827	stem cell maintenance	2.58e-02	1.00e+00	5.261	1	7	47
GO:0035690	cellular response to drug	2.69e-02	1.00e+00	5.201	1	3	49
GO:0006986	response to unfolded protein	2.74e-02	1.00e+00	5.172	1	4	50
GO:0034976	response to endoplasmic reticulum stress	2.79e-02	1.00e+00	5.144	1	2	51
GO:0045454	cell redox homeostasis	2.79e-02	1.00e+00	5.144	1	1	51
GO:0009611	response to wounding	2.85e-02	1.00e+00	5.116	1	5	52
GO:0007623	circadian rhythm	2.90e-02	1.00e+00	5.088	1	1	53
GO:0071300	cellular response to retinoic acid	3.01e-02	1.00e+00	5.035	1	1	55
GO:0051592	response to calcium ion	3.01e-02	1.00e+00	5.035	1	1	55
GO:0000724	double-strand break repair via homologous recombination	3.01e-02	1.00e+00	5.035	1	2	55
GO:0002039	p53 binding	3.01e-02	1.00e+00	5.035	1	4	55
GO:0043627	response to estrogen	3.06e-02	1.00e+00	5.009	1	5	56
GO:0006396	RNA processing	3.23e-02	1.00e+00	4.933	1	5	59
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	3.23e-02	1.00e+00	4.933	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.23e-02	1.00e+00	4.933	1	6	59
GO:0008013	beta-catenin binding	3.28e-02	1.00e+00	4.909	1	9	60
GO:0032481	positive regulation of type I interferon production	3.33e-02	1.00e+00	4.885	1	6	61
GO:0006987	activation of signaling protein activity involved in unfolded protein response	3.33e-02	1.00e+00	4.885	1	2	61
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	3.44e-02	1.00e+00	4.839	1	4	63
GO:0010468	regulation of gene expression	3.71e-02	1.00e+00	4.729	1	2	68
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.73e-02	1.00e+00	2.661	2	37	570
GO:0006351	transcription, DNA-templated	3.83e-02	1.00e+00	1.903	3	57	1446
GO:0030324	lung development	3.93e-02	1.00e+00	4.646	1	1	72
GO:0000785	chromatin	3.98e-02	1.00e+00	4.626	1	6	73
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.03e-02	1.00e+00	4.607	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.09e-02	1.00e+00	4.587	1	1	75
GO:0001889	liver development	4.19e-02	1.00e+00	4.549	1	3	77
GO:0071013	catalytic step 2 spliceosome	4.25e-02	1.00e+00	4.531	1	7	78
GO:0030968	endoplasmic reticulum unfolded protein response	4.30e-02	1.00e+00	4.512	1	2	79
GO:0009653	anatomical structure morphogenesis	4.51e-02	1.00e+00	4.441	1	2	83
GO:0009952	anterior/posterior pattern specification	4.51e-02	1.00e+00	4.441	1	4	83
GO:0009887	organ morphogenesis	4.67e-02	1.00e+00	4.390	1	5	86
GO:0090090	negative regulation of canonical Wnt signaling pathway	4.67e-02	1.00e+00	4.390	1	8	86
GO:0045471	response to ethanol	4.67e-02	1.00e+00	4.390	1	3	86
GO:0016363	nuclear matrix	4.94e-02	1.00e+00	4.308	1	6	91
GO:0001649	osteoblast differentiation	4.99e-02	1.00e+00	4.293	1	5	92
GO:0071456	cellular response to hypoxia	4.99e-02	1.00e+00	4.293	1	3	92
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	4.99e-02	1.00e+00	4.293	1	7	92
GO:0010467	gene expression	4.99e-02	1.00e+00	2.430	2	45	669
GO:0005770	late endosome	5.04e-02	1.00e+00	4.277	1	2	93
GO:0051726	regulation of cell cycle	5.26e-02	1.00e+00	4.216	1	5	97
GO:0005938	cell cortex	5.63e-02	1.00e+00	4.116	1	5	104
GO:0001934	positive regulation of protein phosphorylation	5.63e-02	1.00e+00	4.116	1	5	104
GO:0030529	ribonucleoprotein complex	6.05e-02	1.00e+00	4.009	1	5	112
GO:0046983	protein dimerization activity	6.36e-02	1.00e+00	3.933	1	5	118
GO:0006325	chromatin organization	6.36e-02	1.00e+00	3.933	1	12	118
GO:0007219	Notch signaling pathway	6.47e-02	1.00e+00	3.909	1	5	120
GO:0007050	cell cycle arrest	6.68e-02	1.00e+00	3.862	1	5	124
GO:0000086	G2/M transition of mitotic cell cycle	7.30e-02	1.00e+00	3.729	1	4	136
GO:0016055	Wnt signaling pathway	7.40e-02	1.00e+00	3.708	1	4	138
GO:0007507	heart development	7.46e-02	1.00e+00	3.697	1	7	139
GO:0001666	response to hypoxia	7.97e-02	1.00e+00	3.597	1	7	149
GO:0000398	mRNA splicing, via spliceosome	8.74e-02	1.00e+00	3.459	1	15	164
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	8.80e-02	1.00e+00	3.450	1	12	165
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	5	178
GO:0032403	protein complex binding	9.71e-02	1.00e+00	3.300	1	6	183
GO:0006367	transcription initiation from RNA polymerase II promoter	9.76e-02	1.00e+00	3.293	1	22	184
GO:0008270	zinc ion binding	1.01e-01	1.00e+00	1.855	2	27	997
GO:0044822	poly(A) RNA binding	1.12e-01	1.00e+00	1.772	2	50	1056
GO:0008380	RNA splicing	1.20e-01	1.00e+00	2.983	1	22	228
GO:0007283	spermatogenesis	1.36e-01	1.00e+00	2.783	1	3	262
GO:0005829	cytosol	1.47e-01	1.00e+00	1.116	3	86	2496
GO:0007275	multicellular organismal development	1.62e-01	1.00e+00	2.512	1	7	316
GO:0003682	chromatin binding	1.68e-01	1.00e+00	2.463	1	19	327
GO:0008283	cell proliferation	1.68e-01	1.00e+00	2.459	1	14	328
GO:0046982	protein heterodimerization activity	1.92e-01	1.00e+00	2.246	1	8	380
GO:0000278	mitotic cell cycle	1.97e-01	1.00e+00	2.205	1	15	391
GO:0009986	cell surface	2.02e-01	1.00e+00	2.165	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.07e-01	1.00e+00	2.126	1	24	413
GO:0006366	transcription from RNA polymerase II promoter	2.10e-01	1.00e+00	2.105	1	30	419
GO:0044267	cellular protein metabolic process	2.35e-01	1.00e+00	1.927	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	2.36e-01	1.00e+00	1.915	1	24	478
GO:0016032	viral process	2.61e-01	1.00e+00	1.755	1	26	534
GO:0006915	apoptotic process	2.69e-01	1.00e+00	1.700	1	12	555
GO:0005783	endoplasmic reticulum	2.70e-01	1.00e+00	1.697	1	13	556
GO:0045087	innate immune response	2.87e-01	1.00e+00	1.597	1	15	596
GO:0005737	cytoplasm	3.49e-01	1.00e+00	0.522	3	124	3767
GO:0005524	ATP binding	5.30e-01	1.00e+00	0.474	1	31	1298
GO:0005730	nucleolus	6.20e-01	1.00e+00	0.136	1	66	1641
GO:0016020	membrane	6.29e-01	1.00e+00	0.101	1	46	1681

chia-Fav

int-snw-2033

Statistics

Genes (8)

Interactions (9)

Related GO terms (205)