int-snw-1487

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.813 2.83e-15 6.26e-04 4.07e-03
chia-screen-data-Fav-int-snw-1487 subnetwork

Genes (11)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
HCFC1 3054 40-2.9253.44971YesYes
EP300 2033 22-2.2743.120415YesYes
ACTL6B 51412 1-2.0422.81310Yes-
RREB1 6239 2-1.8302.85739--
YAP1 10413 94-4.2563.53853Yes-
APC 324 13-2.2933.004353Yes-
SRSF3 6428 73-2.9923.53854Yes-
NFRKB 4798 48-3.1293.10823YesYes
LDB2 9079 2-2.3802.81827Yes-
POU5F1 5460 133-5.1483.538179YesYes
[ CTBP1 ] 1487 2-1.6782.81895--

Interactions (10)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CTBP1 1487 EP300 2033 pp -- int.I2D: BioGrid, BCI, HPRD;
int.Ravasi: -;
int.HPRD: in vitro, in vivo
NFRKB 4798 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
CTBP1 1487 RREB1 6239 pp -- int.I2D: BioGrid
HCFC1 3054 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
APC 324 CTBP1 1487 pp -- int.I2D: BCI, BioGrid, HPRD, Jorgensen_EphR, BIND;
int.Ravasi: -;
int.HPRD: in vitro, in vivo
CTBP1 1487 ACTL6B 51412 pp -- int.I2D: BioGrid, HPRD;
int.HPRD: in vivo, yeast 2-hybrid
CTBP1 1487 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
EP300 2033 YAP1 10413 pp -- int.I2D: BioGrid
CTBP1 1487 LDB2 9079 pp -- int.Ravasi: -

Related GO terms (275)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0035019somatic stem cell maintenance3.21e-064.63e-026.6203640
GO:0005667transcription factor complex6.47e-069.33e-024.905417175
GO:0006366transcription from RNA polymerase II promoter8.08e-061.17e-013.968530419
GO:0003713transcription coactivator activity2.14e-053.09e-014.468424237
GO:0006355regulation of transcription, DNA-templated3.67e-055.30e-012.980643997
GO:0005634nucleus7.76e-051.00e+001.524101594559
GO:0006325chromatin organization8.40e-051.00e+005.059312118
GO:0003700sequence-specific DNA binding transcription factor activity9.54e-051.00e+003.229539699
GO:0000123histone acetyltransferase complex1.10e-041.00e+006.9642621
GO:0001942hair follicle development3.10e-041.00e+006.2272235
GO:0005730nucleolus5.98e-041.00e+002.2616661641
GO:0008134transcription factor binding6.97e-041.00e+004.023318242
GO:0005654nucleoplasm7.42e-041.00e+002.5995641082
GO:1901985positive regulation of protein acetylation7.63e-041.00e+0010.357111
GO:0043969histone H2B acetylation7.63e-041.00e+0010.357111
GO:0090308regulation of methylation-dependent chromatin silencing7.63e-041.00e+0010.357111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway7.63e-041.00e+0010.357111
GO:0060965negative regulation of gene silencing by miRNA7.63e-041.00e+0010.357111
GO:0042483negative regulation of odontogenesis7.63e-041.00e+0010.357111
GO:0044089positive regulation of cellular component biogenesis7.63e-041.00e+0010.357111
GO:0060795cell fate commitment involved in formation of primary germ layer7.63e-041.00e+0010.357111
GO:0060177regulation of angiotensin metabolic process7.63e-041.00e+0010.357111
GO:0051171regulation of nitrogen compound metabolic process7.63e-041.00e+0010.357111
GO:0034401regulation of transcription by chromatin organization7.63e-041.00e+0010.357111
GO:2000629negative regulation of miRNA metabolic process7.63e-041.00e+0010.357111
GO:0008013beta-catenin binding9.14e-041.00e+005.4502960
GO:0060242contact inhibition1.52e-031.00e+009.357112
GO:0090241negative regulation of histone H4 acetylation1.52e-031.00e+009.357122
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic process1.52e-031.00e+009.357112
GO:0019046release from viral latency1.52e-031.00e+009.357122
GO:0009786regulation of asymmetric cell division1.52e-031.00e+009.357112
GO:0090043regulation of tubulin deacetylation1.52e-031.00e+009.357122
GO:0071389cellular response to mineralocorticoid stimulus1.52e-031.00e+009.357112
GO:0014737positive regulation of muscle atrophy1.52e-031.00e+009.357112
GO:0035984cellular response to trichostatin A1.52e-031.00e+009.357112
GO:0009798axis specification1.52e-031.00e+009.357112
GO:0045944positive regulation of transcription from RNA polymerase II promoter2.15e-031.00e+002.733441789
GO:0018076N-terminal peptidyl-lysine acetylation2.29e-031.00e+008.772113
GO:0060913cardiac cell fate determination2.29e-031.00e+008.772113
GO:0010560positive regulation of glycoprotein biosynthetic process2.29e-031.00e+008.772113
GO:0003130BMP signaling pathway involved in heart induction2.29e-031.00e+008.772113
GO:0051726regulation of cell cycle2.37e-031.00e+004.7572597
GO:0097157pre-mRNA intronic binding3.05e-031.00e+008.357114
GO:0018393internal peptidyl-lysine acetylation3.05e-031.00e+008.357114
GO:0010669epithelial structure maintenance3.05e-031.00e+008.357114
GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor3.05e-031.00e+008.357114
GO:0019887protein kinase regulator activity3.05e-031.00e+008.357114
GO:0070461SAGA-type complex3.81e-031.00e+008.035125
GO:0001714endodermal cell fate specification3.81e-031.00e+008.035115
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process3.81e-031.00e+008.035125
GO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor3.81e-031.00e+008.035115
GO:0065004protein-DNA complex assembly3.81e-031.00e+008.035115
GO:0060298positive regulation of sarcomere organization3.81e-031.00e+008.035115
GO:0032025response to cobalt ion3.81e-031.00e+008.035115
GO:0030858positive regulation of epithelial cell differentiation4.57e-031.00e+007.772116
GO:0007091metaphase/anaphase transition of mitotic cell cycle5.33e-031.00e+007.549127
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development5.33e-031.00e+007.549117
GO:0051988regulation of attachment of spindle microtubules to kinetochore5.33e-031.00e+007.549127
GO:0030274LIM domain binding5.33e-031.00e+007.549117
GO:0006475internal protein amino acid acetylation5.33e-031.00e+007.549117
GO:0006974cellular response to DNA damage stimulus5.63e-031.00e+004.11827151
GO:0045670regulation of osteoclast differentiation6.09e-031.00e+007.357128
GO:0035067negative regulation of histone acetylation6.09e-031.00e+007.357128
GO:0070688MLL5-L complex6.09e-031.00e+007.357118
GO:0043254regulation of protein complex assembly6.09e-031.00e+007.357118
GO:0045667regulation of osteoblast differentiation6.85e-031.00e+007.187119
GO:0035259glucocorticoid receptor binding6.85e-031.00e+007.187119
GO:0045793positive regulation of cell size6.85e-031.00e+007.187129
GO:0043996histone acetyltransferase activity (H4-K8 specific)6.85e-031.00e+007.187159
GO:0043995histone acetyltransferase activity (H4-K5 specific)6.85e-031.00e+007.187159
GO:0046972histone acetyltransferase activity (H4-K16 specific)6.85e-031.00e+007.187159
GO:0060765regulation of androgen receptor signaling pathway6.85e-031.00e+007.187119
GO:0048188Set1C/COMPASS complex6.85e-031.00e+007.187149
GO:0031065positive regulation of histone deacetylation6.85e-031.00e+007.187129
GO:0044212transcription regulatory region DNA binding6.92e-031.00e+003.964217168
GO:0016607nuclear speck7.25e-031.00e+003.930212172
GO:0031274positive regulation of pseudopodium assembly7.60e-031.00e+007.0351210
GO:0050872white fat cell differentiation7.60e-031.00e+007.0351110
GO:0035413positive regulation of catenin import into nucleus7.60e-031.00e+007.0351210
GO:0016407acetyltransferase activity7.60e-031.00e+007.0351210
GO:0030877beta-catenin destruction complex7.60e-031.00e+007.0351210
GO:0000122negative regulation of transcription from RNA polymerase II promoter7.99e-031.00e+002.787337570
GO:0051010microtubule plus-end binding8.36e-031.00e+006.8971111
GO:0031116positive regulation of microtubule polymerization8.36e-031.00e+006.8971111
GO:0043923positive regulation by host of viral transcription8.36e-031.00e+006.8971111
GO:0033160positive regulation of protein import into nucleus, translocation8.36e-031.00e+006.8971311
GO:0042975peroxisome proliferator activated receptor binding8.36e-031.00e+006.8971111
GO:0060391positive regulation of SMAD protein import into nucleus8.36e-031.00e+006.8971411
GO:0032886regulation of microtubule-based process9.12e-031.00e+006.7721112
GO:0071565nBAF complex9.12e-031.00e+006.7721112
GO:0045295gamma-catenin binding9.12e-031.00e+006.7721112
GO:0019079viral genome replication9.12e-031.00e+006.7721212
GO:0035198miRNA binding9.12e-031.00e+006.7721112
GO:0005737cytoplasm9.75e-031.00e+001.28571243767
GO:0071480cellular response to gamma radiation9.87e-031.00e+006.6561113
GO:0042789mRNA transcription from RNA polymerase II promoter9.87e-031.00e+006.6561213
GO:0016746transferase activity, transferring acyl groups9.87e-031.00e+006.6561113
GO:0044295axonal growth cone9.87e-031.00e+006.6561113
GO:0051019mitogen-activated protein kinase binding9.87e-031.00e+006.6561213
GO:0043409negative regulation of MAPK cascade9.87e-031.00e+006.6561213
GO:0003677DNA binding1.03e-021.00e+002.1064491218
GO:0035371microtubule plus-end1.06e-021.00e+006.5491114
GO:0031011Ino80 complex1.06e-021.00e+006.5491614
GO:0070542response to fatty acid1.06e-021.00e+006.5491114
GO:0032993protein-DNA complex1.06e-021.00e+006.5491214
GO:0043981histone H4-K5 acetylation1.14e-021.00e+006.4501515
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.14e-021.00e+006.4501315
GO:0016514SWI/SNF complex1.14e-021.00e+006.4501115
GO:0001824blastocyst development1.14e-021.00e+006.4501215
GO:0043982histone H4-K8 acetylation1.14e-021.00e+006.4501515
GO:1990090cellular response to nerve growth factor stimulus1.14e-021.00e+006.4501115
GO:0007026negative regulation of microtubule depolymerization1.21e-021.00e+006.3571116
GO:0046716muscle cell cellular homeostasis1.21e-021.00e+006.3571116
GO:0043274phospholipase binding1.21e-021.00e+006.3571116
GO:0051276chromosome organization1.21e-021.00e+006.3571216
GO:0007399nervous system development1.28e-021.00e+003.50526231
GO:0031122cytoplasmic microtubule organization1.36e-021.00e+006.1871118
GO:0045773positive regulation of axon extension1.36e-021.00e+006.1871118
GO:0033613activating transcription factor binding1.36e-021.00e+006.1871318
GO:0043984histone H4-K16 acetylation1.44e-021.00e+006.1091519
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity1.44e-021.00e+006.1091219
GO:0035257nuclear hormone receptor binding1.44e-021.00e+006.1091119
GO:0071549cellular response to dexamethasone stimulus1.52e-021.00e+006.0351320
GO:0010942positive regulation of cell death1.52e-021.00e+006.0351120
GO:0001106RNA polymerase II transcription corepressor activity1.59e-021.00e+005.9641221
GO:0032967positive regulation of collagen biosynthetic process1.59e-021.00e+005.9641321
GO:0045862positive regulation of proteolysis1.59e-021.00e+005.9641221
GO:0009954proximal/distal pattern formation1.59e-021.00e+005.9641121
GO:0000281mitotic cytokinesis1.59e-021.00e+005.9641221
GO:0003823antigen binding1.67e-021.00e+005.8971222
GO:0045787positive regulation of cell cycle1.67e-021.00e+005.8971222
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription1.67e-021.00e+005.8971422
GO:0043388positive regulation of DNA binding1.82e-021.00e+005.7721224
GO:0045296cadherin binding1.82e-021.00e+005.7721324
GO:0043425bHLH transcription factor binding1.82e-021.00e+005.7721124
GO:0051059NF-kappaB binding1.89e-021.00e+005.7131325
GO:0035329hippo signaling1.97e-021.00e+005.6561526
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.97e-021.00e+005.6561126
GO:0048565digestive tract development1.97e-021.00e+005.6561226
GO:0034612response to tumor necrosis factor2.04e-021.00e+005.6021227
GO:0071339MLL1 complex2.04e-021.00e+005.6021627
GO:0043967histone H4 acetylation2.04e-021.00e+005.6021127
GO:0050714positive regulation of protein secretion2.12e-021.00e+005.5491328
GO:0070491repressing transcription factor binding2.12e-021.00e+005.5491228
GO:0070830tight junction assembly2.12e-021.00e+005.5491128
GO:0005913cell-cell adherens junction2.19e-021.00e+005.4991329
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator2.27e-021.00e+005.4501130
GO:0009953dorsal/ventral pattern formation2.34e-021.00e+005.4021231
GO:0016604nuclear body2.34e-021.00e+005.4021331
GO:0007094mitotic spindle assembly checkpoint2.34e-021.00e+005.4021331
GO:0043491protein kinase B signaling2.41e-021.00e+005.3571232
GO:1903507negative regulation of nucleic acid-templated transcription2.41e-021.00e+005.3571232
GO:0051287NAD binding2.41e-021.00e+005.3571232
GO:0003682chromatin binding2.46e-021.00e+003.004219327
GO:0001756somitogenesis2.49e-021.00e+005.3121133
GO:0033077T cell differentiation in thymus2.49e-021.00e+005.3121133
GO:0071333cellular response to glucose stimulus2.49e-021.00e+005.3121133
GO:0001102RNA polymerase II activating transcription factor binding2.71e-021.00e+005.1871136
GO:0048538thymus development2.71e-021.00e+005.1871236
GO:0008285negative regulation of cell proliferation2.84e-021.00e+002.893210353
GO:0031490chromatin DNA binding2.86e-021.00e+005.1091238
GO:0032092positive regulation of protein binding2.86e-021.00e+005.1091238
GO:0050681androgen receptor binding2.86e-021.00e+005.1091138
GO:0051781positive regulation of cell division2.94e-021.00e+005.0711139
GO:0005881cytoplasmic microtubule3.01e-021.00e+005.0351140
GO:0045785positive regulation of cell adhesion3.01e-021.00e+005.0351240
GO:0046332SMAD binding3.01e-021.00e+005.0351240
GO:0071320cellular response to cAMP3.01e-021.00e+005.0351140
GO:0007519skeletal muscle tissue development3.01e-021.00e+005.0351240
GO:0070301cellular response to hydrogen peroxide3.08e-021.00e+004.9991241
GO:0031124mRNA 3'-end processing3.16e-021.00e+004.9641242
GO:0004402histone acetyltransferase activity3.23e-021.00e+004.9301643
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding3.31e-021.00e+004.8971444
GO:0003712transcription cofactor activity3.31e-021.00e+004.8971844
GO:0045727positive regulation of translation3.31e-021.00e+004.8971244
GO:0043966histone H3 acetylation3.38e-021.00e+004.8651545
GO:0001047core promoter binding3.38e-021.00e+004.8651545
GO:0006369termination of RNA polymerase II transcription3.38e-021.00e+004.8651245
GO:0016328lateral plasma membrane3.45e-021.00e+004.8331346
GO:0006921cellular component disassembly involved in execution phase of apoptosis3.53e-021.00e+004.8021247
GO:0007030Golgi organization3.68e-021.00e+004.7421349
GO:0035690cellular response to drug3.68e-021.00e+004.7421349
GO:0045732positive regulation of protein catabolic process3.75e-021.00e+004.7131150
GO:0045892negative regulation of transcription, DNA-templated3.79e-021.00e+002.667224413
GO:0060041retina development in camera-type eye3.82e-021.00e+004.6841251
GO:0017053transcriptional repressor complex3.82e-021.00e+004.6841251
GO:0005515protein binding3.84e-021.00e+000.80081986024
GO:0009611response to wounding3.90e-021.00e+004.6561552
GO:0007623circadian rhythm3.97e-021.00e+004.6291153
GO:0051592response to calcium ion4.12e-021.00e+004.5751155
GO:0002039p53 binding4.12e-021.00e+004.5751455
GO:0071300cellular response to retinoic acid4.12e-021.00e+004.5751155
GO:0043627response to estrogen4.19e-021.00e+004.5491556
GO:0032481positive regulation of type I interferon production4.56e-021.00e+004.4261661
GO:0006406mRNA export from nucleus4.56e-021.00e+004.4261461
GO:0000776kinetochore4.70e-021.00e+004.3791563
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process4.70e-021.00e+004.3791463
GO:0006310DNA recombination4.85e-021.00e+004.3341765
GO:0007409axonogenesis4.85e-021.00e+004.3341265
GO:0006338chromatin remodeling4.92e-021.00e+004.3121366
GO:0010468regulation of gene expression5.07e-021.00e+004.2691268
GO:0032587ruffle membrane5.21e-021.00e+004.2271370
GO:0030324lung development5.36e-021.00e+004.1871172
GO:0000785chromatin5.43e-021.00e+004.1671673
GO:0002020protease binding5.50e-021.00e+004.1471674
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.50e-021.00e+004.1471474
GO:0060070canonical Wnt signaling pathway5.58e-021.00e+004.1281475
GO:0007265Ras protein signal transduction5.58e-021.00e+004.1281375
GO:0001889liver development5.72e-021.00e+004.0901377
GO:0001822kidney development5.79e-021.00e+004.0711378
GO:0009653anatomical structure morphogenesis6.15e-021.00e+003.9821283
GO:0009952anterior/posterior pattern specification6.15e-021.00e+003.9821483
GO:0005923tight junction6.37e-021.00e+003.9301286
GO:0009887organ morphogenesis6.37e-021.00e+003.9301586
GO:0090090negative regulation of canonical Wnt signaling pathway6.37e-021.00e+003.9301886
GO:0045471response to ethanol6.37e-021.00e+003.9301386
GO:0006915apoptotic process6.46e-021.00e+002.240212555
GO:0050821protein stabilization6.51e-021.00e+003.8971388
GO:0005200structural constituent of cytoskeleton6.73e-021.00e+003.8491691
GO:0071456cellular response to hypoxia6.80e-021.00e+003.8331392
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity6.80e-021.00e+003.8331792
GO:0001934positive regulation of protein phosphorylation7.65e-021.00e+003.65615104
GO:0006461protein complex assembly8.15e-021.00e+003.56214111
GO:0007219Notch signaling pathway8.78e-021.00e+003.45015120
GO:0010467gene expression8.95e-021.00e+001.971245669
GO:0006351transcription, DNA-templated9.00e-021.00e+001.4443571446
GO:0007050cell cycle arrest9.06e-021.00e+003.40215124
GO:0030027lamellipodium9.13e-021.00e+003.39117125
GO:0030335positive regulation of cell migration9.27e-021.00e+003.36815127
GO:0016477cell migration9.34e-021.00e+003.35714128
GO:0000086G2/M transition of mitotic cell cycle9.90e-021.00e+003.26914136
GO:0007507heart development1.01e-011.00e+003.23817139
GO:0010628positive regulation of gene expression1.06e-011.00e+003.16717146
GO:0008017microtubule binding1.07e-011.00e+003.15712147
GO:0005829cytosol1.07e-011.00e+001.0714862496
GO:0001666response to hypoxia1.08e-011.00e+003.13717149
GO:0008022protein C-terminus binding1.16e-011.00e+003.02618161
GO:0000398mRNA splicing, via spliceosome1.18e-011.00e+002.999115164
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.19e-011.00e+002.990112165
GO:0007049cell cycle1.25e-011.00e+002.91416174
GO:0019904protein domain specific binding1.28e-011.00e+002.87318179
GO:0031625ubiquitin protein ligase binding1.28e-011.00e+002.88115178
GO:0003714transcription corepressor activity1.28e-011.00e+002.881111178
GO:0032403protein complex binding1.31e-011.00e+002.84116183
GO:0006367transcription initiation from RNA polymerase II promoter1.32e-011.00e+002.833122184
GO:0008380RNA splicing1.61e-011.00e+002.524122228
GO:0043025neuronal cell body1.72e-011.00e+002.42019245
GO:0000166nucleotide binding1.81e-011.00e+002.340113259
GO:0006281DNA repair1.82e-011.00e+002.329114261
GO:0006357regulation of transcription from RNA polymerase II promoter1.84e-011.00e+002.312123264
GO:0043065positive regulation of apoptotic process1.86e-011.00e+002.29117268
GO:0044822poly(A) RNA binding1.90e-011.00e+001.3122501056
GO:0006954inflammatory response1.92e-011.00e+002.24316277
GO:0019899enzyme binding1.92e-011.00e+002.24319277
GO:0007275multicellular organismal development2.16e-011.00e+002.05317316
GO:0019901protein kinase binding2.17e-011.00e+002.048118317
GO:0005813centrosome2.22e-011.00e+002.00817326
GO:0008283cell proliferation2.24e-011.00e+001.999114328
GO:0003723RNA binding2.32e-011.00e+001.939118342
GO:0043565sequence-specific DNA binding2.34e-011.00e+001.922111346
GO:0007155cell adhesion2.48e-011.00e+001.82915369
GO:0000278mitotic cell cycle2.61e-011.00e+001.746115391
GO:0055114oxidation-reduction process2.78e-011.00e+001.642110420
GO:0006468protein phosphorylation3.00e-011.00e+001.511110460
GO:0045893positive regulation of transcription, DNA-templated3.10e-011.00e+001.456124478
GO:0042802identical protein binding3.13e-011.00e+001.438119484
GO:0016032viral process3.40e-011.00e+001.296126534
GO:0042803protein homodimerization activity3.71e-011.00e+001.140119595
GO:0045087innate immune response3.71e-011.00e+001.137115596
GO:0008270zinc ion binding5.45e-011.00e+000.395127997
GO:0005739mitochondrion5.46e-011.00e+000.394123998
GO:0046872metal ion binding6.48e-011.00e+000.0051291307
GO:0016020membrane7.44e-011.00e+00-0.3581461681
GO:0070062extracellular vesicular exosome8.65e-011.00e+00-0.8721572400
GO:0005886plasma membrane8.86e-011.00e+00-0.9781492582