int-snw-124944

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.884	4.90e-16	2.66e-04	2.22e-03

chia-screen-data-Fav-int-snw-124944 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
MCRS1	10445	14	-2.660	3.079	63	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
WDR82	80335	7	-2.455	3.129	64	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
WDR5	11091	1	-0.661	2.884	173	-	-
[ C17orf49 ]	124944	1	-0.458	2.884	3	-	-

Interactions (15)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
NFRKB	4798	MCRS1	10445	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
POU5F1	5460	C17orf49	124944	pp	--	int.I2D: BioGrid_Mouse
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HCFC1	3054	WDR82	80335	pp	--	int.I2D: BioGrid
MCRS1	10445	WDR5	11091	pp	--	int.Intact: MI:0914(association)
HCFC1	3054	WDR5	11091	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid, IntAct
WDR82	80335	C17orf49	124944	pp	--	int.I2D: BioGrid
WDR5	11091	WDR82	80335	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, BioGrid, YeastLow
PSMD2	5708	WDR5	11091	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
WDR5	11091	C17orf49	124944	pp	--	int.Intact: MI:0914(association)
POU5F1	5460	WDR5	11091	pp	--	int.I2D: BioGrid, BioGrid_Mouse

Related GO terms (132)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0071339	MLL1 complex	3.18e-09	4.59e-05	7.602	4	6	27
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	2.77e-08	3.99e-04	8.772	3	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	2.77e-08	3.99e-04	8.772	3	5	9
GO:0048188	Set1C/COMPASS complex	2.77e-08	3.99e-04	8.772	3	4	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	2.77e-08	3.99e-04	8.772	3	5	9
GO:0005654	nucleoplasm	1.32e-07	1.90e-03	3.277	8	64	1082
GO:0043981	histone H4-K5 acetylation	1.49e-07	2.16e-03	8.035	3	5	15
GO:0043982	histone H4-K8 acetylation	1.49e-07	2.16e-03	8.035	3	5	15
GO:0043984	histone H4-K16 acetylation	3.18e-07	4.58e-03	7.694	3	5	19
GO:0000123	histone acetyltransferase complex	4.36e-07	6.28e-03	7.549	3	6	21
GO:0006355	regulation of transcription, DNA-templated	3.67e-05	5.30e-01	2.980	6	43	997
GO:0042800	histone methyltransferase activity (H3-K4 specific)	4.11e-05	5.92e-01	7.656	2	3	13
GO:0031011	Ino80 complex	4.79e-05	6.91e-01	7.549	2	6	14
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	5.52e-05	7.97e-01	7.450	2	3	15
GO:0051568	histone H3-K4 methylation	7.15e-05	1.00e+00	7.269	2	3	17
GO:0006325	chromatin organization	8.40e-05	1.00e+00	5.059	3	12	118
GO:0035097	histone methyltransferase complex	1.10e-04	1.00e+00	6.964	2	3	21
GO:0006366	transcription from RNA polymerase II promoter	1.97e-04	1.00e+00	3.646	4	30	419
GO:0060795	cell fate commitment involved in formation of primary germ layer	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	7.63e-04	1.00e+00	10.357	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	7.63e-04	1.00e+00	10.357	1	1	1
GO:0006310	DNA recombination	1.07e-03	1.00e+00	5.334	2	7	65
GO:0005515	protein binding	1.10e-03	1.00e+00	1.122	10	198	6024
GO:0010467	gene expression	1.17e-03	1.00e+00	2.971	4	45	669
GO:0060242	contact inhibition	1.52e-03	1.00e+00	9.357	1	1	2
GO:0019046	release from viral latency	1.52e-03	1.00e+00	9.357	1	2	2
GO:0009786	regulation of asymmetric cell division	1.52e-03	1.00e+00	9.357	1	1	2
GO:0003682	chromatin binding	1.66e-03	1.00e+00	3.588	3	19	327
GO:0060913	cardiac cell fate determination	2.29e-03	1.00e+00	8.772	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.29e-03	1.00e+00	8.772	1	1	3
GO:0070461	SAGA-type complex	3.81e-03	1.00e+00	8.035	1	2	5
GO:0001714	endodermal cell fate specification	3.81e-03	1.00e+00	8.035	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.81e-03	1.00e+00	8.035	1	2	5
GO:0016589	NURF complex	4.57e-03	1.00e+00	7.772	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	4.57e-03	1.00e+00	7.772	1	3	6
GO:0072357	PTW/PP1 phosphatase complex	5.33e-03	1.00e+00	7.549	1	2	7
GO:0070688	MLL5-L complex	6.09e-03	1.00e+00	7.357	1	1	8
GO:0043254	regulation of protein complex assembly	6.09e-03	1.00e+00	7.357	1	1	8
GO:0000398	mRNA splicing, via spliceosome	6.61e-03	1.00e+00	3.999	2	15	164
GO:0044212	transcription regulatory region DNA binding	6.92e-03	1.00e+00	3.964	2	17	168
GO:0035413	positive regulation of catenin import into nucleus	7.60e-03	1.00e+00	7.035	1	2	10
GO:0060391	positive regulation of SMAD protein import into nucleus	8.36e-03	1.00e+00	6.897	1	4	11
GO:0005838	proteasome regulatory particle	9.12e-03	1.00e+00	6.772	1	1	12
GO:0035198	miRNA binding	9.12e-03	1.00e+00	6.772	1	1	12
GO:0071480	cellular response to gamma radiation	9.87e-03	1.00e+00	6.656	1	1	13
GO:0045722	positive regulation of gluconeogenesis	9.87e-03	1.00e+00	6.656	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	9.87e-03	1.00e+00	6.656	1	2	13
GO:0030234	enzyme regulator activity	9.87e-03	1.00e+00	6.656	1	2	13
GO:0003677	DNA binding	1.03e-02	1.00e+00	2.106	4	49	1218
GO:0001824	blastocyst development	1.14e-02	1.00e+00	6.450	1	2	15
GO:0043274	phospholipase binding	1.21e-02	1.00e+00	6.357	1	1	16
GO:0042176	regulation of protein catabolic process	1.21e-02	1.00e+00	6.357	1	2	16
GO:0008380	RNA splicing	1.25e-02	1.00e+00	3.524	2	22	228
GO:0022624	proteasome accessory complex	1.29e-02	1.00e+00	6.269	1	1	17
GO:0003713	transcription coactivator activity	1.34e-02	1.00e+00	3.468	2	24	237
GO:0006281	DNA repair	1.61e-02	1.00e+00	3.329	2	14	261
GO:0045787	positive regulation of cell cycle	1.67e-02	1.00e+00	5.897	1	2	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.67e-02	1.00e+00	5.897	1	4	22
GO:0035329	hippo signaling	1.97e-02	1.00e+00	5.656	1	5	26
GO:1903507	negative regulation of nucleic acid-templated transcription	2.41e-02	1.00e+00	5.357	1	2	32
GO:0003723	RNA binding	2.68e-02	1.00e+00	2.939	2	18	342
GO:0005634	nucleus	2.89e-02	1.00e+00	1.010	7	159	4559
GO:0035019	somatic stem cell maintenance	3.01e-02	1.00e+00	5.035	1	6	40
GO:0031124	mRNA 3'-end processing	3.16e-02	1.00e+00	4.964	1	2	42
GO:0043966	histone H3 acetylation	3.38e-02	1.00e+00	4.865	1	5	45
GO:0006369	termination of RNA polymerase II transcription	3.38e-02	1.00e+00	4.865	1	2	45
GO:0006521	regulation of cellular amino acid metabolic process	3.75e-02	1.00e+00	4.713	1	1	50
GO:0009611	response to wounding	3.90e-02	1.00e+00	4.656	1	5	52
GO:0044822	poly(A) RNA binding	4.14e-02	1.00e+00	1.897	3	50	1056
GO:0000502	proteasome complex	4.34e-02	1.00e+00	4.499	1	3	58
GO:0006396	RNA processing	4.41e-02	1.00e+00	4.474	1	5	59
GO:0006406	mRNA export from nucleus	4.56e-02	1.00e+00	4.426	1	4	61
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.78e-02	1.00e+00	4.357	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.85e-02	1.00e+00	4.334	1	2	65
GO:0010468	regulation of gene expression	5.07e-02	1.00e+00	4.269	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.21e-02	1.00e+00	4.227	1	2	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.36e-02	1.00e+00	4.187	1	1	72
GO:0000785	chromatin	5.43e-02	1.00e+00	4.167	1	6	73
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.50e-02	1.00e+00	4.147	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.50e-02	1.00e+00	4.147	1	2	74
GO:0002020	protease binding	5.50e-02	1.00e+00	4.147	1	6	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.58e-02	1.00e+00	4.128	1	1	75
GO:0071013	catalytic step 2 spliceosome	5.79e-02	1.00e+00	4.071	1	7	78
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.86e-02	1.00e+00	4.053	1	2	79
GO:0009653	anatomical structure morphogenesis	6.15e-02	1.00e+00	3.982	1	2	83
GO:0006464	cellular protein modification process	6.23e-02	1.00e+00	3.964	1	4	84
GO:0050821	protein stabilization	6.51e-02	1.00e+00	3.897	1	3	88
GO:0001649	osteoblast differentiation	6.80e-02	1.00e+00	3.833	1	5	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.80e-02	1.00e+00	3.833	1	1	92
GO:0016568	chromatin modification	7.23e-02	1.00e+00	3.742	1	4	98
GO:0030529	ribonucleoprotein complex	8.22e-02	1.00e+00	3.549	1	5	112
GO:0000209	protein polyubiquitination	8.50e-02	1.00e+00	3.499	1	3	116
GO:0001501	skeletal system development	8.71e-02	1.00e+00	3.462	1	2	119
GO:0003700	sequence-specific DNA binding transcription factor activity	9.66e-02	1.00e+00	1.908	2	39	699
GO:0010628	positive regulation of gene expression	1.06e-01	1.00e+00	3.167	1	7	146
GO:0000082	G1/S transition of mitotic cell cycle	1.08e-01	1.00e+00	3.137	1	3	149
GO:0006974	cellular response to DNA damage stimulus	1.09e-01	1.00e+00	3.118	1	7	151
GO:0042981	regulation of apoptotic process	1.09e-01	1.00e+00	3.128	1	4	150
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.19e-01	1.00e+00	1.733	2	41	789
GO:0005730	nucleolus	1.21e-01	1.00e+00	1.261	3	66	1641
GO:0034641	cellular nitrogen compound metabolic process	1.23e-01	1.00e+00	2.939	1	2	171
GO:0016607	nuclear speck	1.24e-01	1.00e+00	2.930	1	12	172
GO:0007049	cell cycle	1.25e-01	1.00e+00	2.914	1	6	174
GO:0005667	transcription factor complex	1.26e-01	1.00e+00	2.905	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.28e-01	1.00e+00	2.881	1	5	178
GO:0003714	transcription corepressor activity	1.28e-01	1.00e+00	2.881	1	11	178
GO:0016020	membrane	1.28e-01	1.00e+00	1.227	3	46	1681
GO:0006367	transcription initiation from RNA polymerase II promoter	1.32e-01	1.00e+00	2.833	1	22	184
GO:0005737	cytoplasm	1.33e-01	1.00e+00	0.799	5	124	3767
GO:0016071	mRNA metabolic process	1.58e-01	1.00e+00	2.556	1	8	223
GO:0008134	transcription factor binding	1.70e-01	1.00e+00	2.438	1	18	242
GO:0043025	neuronal cell body	1.72e-01	1.00e+00	2.420	1	9	245
GO:0016070	RNA metabolic process	1.73e-01	1.00e+00	2.408	1	8	247
GO:0000166	nucleotide binding	1.81e-01	1.00e+00	2.340	1	13	259
GO:0006954	inflammatory response	1.92e-01	1.00e+00	2.243	1	6	277
GO:0008283	cell proliferation	2.24e-01	1.00e+00	1.999	1	14	328
GO:0043565	sequence-specific DNA binding	2.34e-01	1.00e+00	1.922	1	11	346
GO:0000278	mitotic cell cycle	2.61e-01	1.00e+00	1.746	1	15	391
GO:0009986	cell surface	2.67e-01	1.00e+00	1.706	1	9	402
GO:0043066	negative regulation of apoptotic process	2.80e-01	1.00e+00	1.629	1	16	424
GO:0005829	cytosol	2.94e-01	1.00e+00	0.656	3	86	2496
GO:0006351	transcription, DNA-templated	3.04e-01	1.00e+00	0.859	2	57	1446
GO:0042802	identical protein binding	3.13e-01	1.00e+00	1.438	1	19	484
GO:0016032	viral process	3.40e-01	1.00e+00	1.296	1	26	534
GO:0006915	apoptotic process	3.51e-01	1.00e+00	1.240	1	12	555
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.58e-01	1.00e+00	1.202	1	37	570
GO:0005739	mitochondrion	5.46e-01	1.00e+00	0.394	1	23	998
GO:0044281	small molecule metabolic process	6.19e-01	1.00e+00	0.115	1	20	1211
GO:0005524	ATP binding	6.46e-01	1.00e+00	0.015	1	31	1298
GO:0070062	extracellular vesicular exosome	8.65e-01	1.00e+00	-0.872	1	57	2400

chia-Fav

int-snw-124944

Statistics

Genes (11)

Interactions (15)

Related GO terms (132)