int-snw-1114

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.789 5.18e-15 8.34e-04 4.99e-03
chia-screen-data-Fav-int-snw-1114 subnetwork

Genes (18)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
HCFC1 3054 40-2.9253.44971YesYes
[ CHGB ] 1114 1-1.4402.78931--
LARS 51520 14-2.5743.157105YesYes
MED19 219541 30-2.6573.449115Yes-
POLR2L 5441 2-1.9723.15963--
MED28 80306 16-2.4043.21680Yes-
POLR2D 5433 3-1.9983.21636--
YAP1 10413 94-4.2563.53853Yes-
POU5F1 5460 133-5.1483.538179YesYes
APLP2 334 12-2.7323.20635YesYes
PSMD2 5708 47-4.1723.157386YesYes
EIF2S2 8894 9-2.9992.96881YesYes
EIF2S3 1968 1-1.9402.789198--
LUC7L3 51747 33-3.5233.44918Yes-
POLR2E 5434 4-2.0373.157115Yes-
MED12 9968 14-2.4653.20665Yes-
POLR2H 5437 1-1.9602.78941--
SRSF3 6428 73-2.9923.53854Yes-

Interactions (31)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CHGB 1114 POLR2E 5434 pp -- int.Intact: MI:0915(physical association);
int.I2D: HPRD, IntAct, MINT, StelzlLow;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
SRSF3 6428 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
POLR2D 5433 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
POLR2E 5434 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
POLR2D 5433 MED28 80306 pp -- int.I2D: BioGrid
HCFC1 3054 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
POLR2D 5433 POLR2H 5437 pp -- int.I2D: BCI, BioGrid, BIND, HPRD;
int.Ravasi: -;
int.HPRD: in vitro
POLR2E 5434 POLR2L 5441 pp -- int.I2D: BCI, BioGrid, BioGrid_Yeast, HPRD, Krogan_Core, MINT_Yeast, YeastMedium, BIND;
int.Ravasi: -;
int.HPRD: in vitro
HCFC1 3054 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
EIF2S3 1968 LARS 51520 pp -- int.I2D: YeastLow
POLR2E 5434 MED28 80306 pp -- int.I2D: BioGrid
MED28 80306 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
POLR2L 5441 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
YAP1 10413 MED28 80306 pp -- int.I2D: MINT;
int.Mint: MI:0915(physical association)
APLP2 334 MED12 9968 pp -- int.I2D: MINT;
int.Mint: MI:0407(direct interaction)
POLR2H 5437 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
EIF2S3 1968 EIF2S2 8894 pp -- int.Intact: MI:0407(direct interaction);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, MINT_Yeast, YeastHigh, Yu_GoldStd
EIF2S3 1968 PSMD2 5708 pp -- int.I2D: BioGrid_Yeast, YeastLow
POLR2E 5434 MED12 9968 pp -- int.I2D: BioGrid
MED12 9968 MED28 80306 pp -- int.I2D: BioGrid
MED12 9968 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
POU5F1 5460 SRSF3 6428 pp -- int.I2D: BioGrid
POLR2E 5434 POLR2H 5437 pp -- int.I2D: BCI, BioGrid, BIND, HPRD;
int.Ravasi: -;
int.HPRD: in vitro
POLR2H 5437 POLR2L 5441 pp -- int.I2D: BCI, BIND, HPRD, BioGrid;
int.Ravasi: -;
int.HPRD: in vitro
LUC7L3 51747 MED19 219541 pp -- int.Intact: MI:0914(association);
int.I2D: IntAct
POLR2D 5433 POLR2E 5434 pp -- int.I2D: BCI, BioGrid, BIND, HPRD;
int.Ravasi: -;
int.HPRD: in vitro
PSMD2 5708 LARS 51520 pp -- int.I2D: BioGrid_Yeast
EIF2S3 1968 POLR2E 5434 pp -- int.I2D: YeastLow
POLR2L 5441 MED28 80306 pp -- int.I2D: BioGrid
POLR2D 5433 POLR2L 5441 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BioGrid, BIND, HPRD;
int.Ravasi: -;
int.HPRD: in vitro
POLR2E 5434 LARS 51520 pp -- int.I2D: YeastLow

Related GO terms (211)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0010467gene expression4.66e-116.73e-073.7201145669
GO:0005665DNA-directed RNA polymerase II, core complex3.06e-094.42e-057.6464416
GO:0006366transcription from RNA polymerase II promoter1.61e-082.32e-043.935830419
GO:00063707-methylguanosine mRNA capping4.56e-086.58e-046.7394530
GO:0006367transcription initiation from RNA polymerase II promoter6.49e-089.37e-044.708622184
GO:0001055RNA polymerase II activity9.10e-081.31e-038.231338
GO:0005654nucleoplasm1.36e-071.96e-032.88910641082
GO:0050434positive regulation of viral transcription2.23e-073.22e-036.1874544
GO:0008380RNA splicing2.31e-073.34e-034.398622228
GO:0006283transcription-coupled nucleotide-excision repair2.68e-073.87e-036.1234446
GO:0001054RNA polymerase I activity2.68e-073.86e-037.7723311
GO:0005736DNA-directed RNA polymerase I complex3.57e-075.14e-037.6463312
GO:0001056RNA polymerase III activity9.05e-071.30e-027.2313316
GO:0005666DNA-directed RNA polymerase III complex1.10e-061.58e-027.1443317
GO:0006368transcription elongation from RNA polymerase II promoter1.24e-061.79e-025.5804667
GO:0006289nucleotide-excision repair1.32e-061.90e-025.5594568
GO:0006386termination of RNA polymerase III transcription1.32e-061.90e-027.0613318
GO:0006385transcription elongation from RNA polymerase III promoter1.32e-061.90e-027.0613318
GO:0000398mRNA splicing, via spliceosome1.36e-061.96e-024.611515164
GO:0003899DNA-directed RNA polymerase activity3.69e-065.32e-026.5873325
GO:0006360transcription from RNA polymerase I promoter6.49e-069.36e-026.3243330
GO:0016592mediator complex1.04e-051.50e-016.10231035
GO:0006383transcription from RNA polymerase III promoter1.45e-052.09e-015.9463339
GO:0032481positive regulation of type I interferon production5.61e-058.10e-015.3003661
GO:0006281DNA repair2.63e-041.00e+003.618414261
GO:0016032viral process3.92e-041.00e+002.907526534
GO:0008135translation factor activity, nucleic acid binding3.99e-041.00e+006.0612324
GO:0001104RNA polymerase II transcription cofactor activity7.59e-041.00e+005.6022833
GO:0060795cell fate commitment involved in formation of primary germ layer1.25e-031.00e+009.646111
GO:0090308regulation of methylation-dependent chromatin silencing1.25e-031.00e+009.646111
GO:0034402recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex1.25e-031.00e+009.646111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway1.25e-031.00e+009.646111
GO:0060965negative regulation of gene silencing by miRNA1.25e-031.00e+009.646111
GO:0005829cytosol1.48e-031.00e+001.5319862496
GO:0019827stem cell maintenance1.54e-031.00e+005.0922747
GO:0003743translation initiation factor activity1.67e-031.00e+005.0312749
GO:0005515protein binding2.10e-031.00e+000.897141986024
GO:0005634nucleus2.35e-031.00e+001.077121594559
GO:0006429leucyl-tRNA aminoacylation2.49e-031.00e+008.646112
GO:0060242contact inhibition2.49e-031.00e+008.646112
GO:0031990mRNA export from nucleus in response to heat stress2.49e-031.00e+008.646122
GO:0019046release from viral latency2.49e-031.00e+008.646122
GO:0002176male germ cell proliferation2.49e-031.00e+008.646112
GO:0009786regulation of asymmetric cell division2.49e-031.00e+008.646112
GO:0004823leucine-tRNA ligase activity2.49e-031.00e+008.646112
GO:0003677DNA binding2.74e-031.00e+001.9816491218
GO:0003713transcription coactivator activity2.98e-031.00e+003.342324237
GO:0005850eukaryotic translation initiation factor 2 complex3.74e-031.00e+008.061113
GO:0046914transition metal ion binding3.74e-031.00e+008.061113
GO:0060913cardiac cell fate determination3.74e-031.00e+008.061113
GO:0003130BMP signaling pathway involved in heart induction3.74e-031.00e+008.061113
GO:0090245axis elongation involved in somitogenesis3.74e-031.00e+008.061113
GO:0014044Schwann cell development4.98e-031.00e+007.646114
GO:0051151negative regulation of smooth muscle cell differentiation4.98e-031.00e+007.646114
GO:0070461SAGA-type complex6.23e-031.00e+007.324125
GO:0001714endodermal cell fate specification6.23e-031.00e+007.324115
GO:0007176regulation of epidermal growth factor-activated receptor activity6.23e-031.00e+007.324115
GO:0006356regulation of transcription from RNA polymerase I promoter7.47e-031.00e+007.061116
GO:0002161aminoacyl-tRNA editing activity8.71e-031.00e+006.839127
GO:0007617mating behavior9.94e-031.00e+006.646118
GO:0070688MLL5-L complex9.94e-031.00e+006.646118
GO:0043254regulation of protein complex assembly9.94e-031.00e+006.646118
GO:0043995histone acetyltransferase activity (H4-K5 specific)1.12e-021.00e+006.476159
GO:0046972histone acetyltransferase activity (H4-K16 specific)1.12e-021.00e+006.476159
GO:0048188Set1C/COMPASS complex1.12e-021.00e+006.476149
GO:0006450regulation of translational fidelity1.12e-021.00e+006.476129
GO:0043996histone acetyltransferase activity (H4-K8 specific)1.12e-021.00e+006.476159
GO:0006413translational initiation1.14e-021.00e+003.61327131
GO:0035413positive regulation of catenin import into nucleus1.24e-021.00e+006.3241210
GO:0060071Wnt signaling pathway, planar cell polarity pathway1.24e-021.00e+006.3241110
GO:0060391positive regulation of SMAD protein import into nucleus1.36e-021.00e+006.1871411
GO:0006878cellular copper ion homeostasis1.49e-021.00e+006.0611112
GO:0005838proteasome regulatory particle1.49e-021.00e+006.0611112
GO:0035198miRNA binding1.49e-021.00e+006.0611112
GO:0045948positive regulation of translational initiation1.49e-021.00e+006.0611112
GO:0071480cellular response to gamma radiation1.61e-021.00e+005.9461113
GO:0042789mRNA transcription from RNA polymerase II promoter1.61e-021.00e+005.9461213
GO:0030234enzyme regulator activity1.61e-021.00e+005.9461213
GO:0001967suckling behavior1.73e-021.00e+005.8391114
GO:0030518intracellular steroid hormone receptor signaling pathway1.73e-021.00e+005.8391614
GO:0005685U1 snRNP1.73e-021.00e+005.8391114
GO:0044212transcription regulatory region DNA binding1.83e-021.00e+003.254217168
GO:0043981histone H4-K5 acetylation1.86e-021.00e+005.7391515
GO:0031369translation initiation factor binding1.86e-021.00e+005.7391215
GO:0042809vitamin D receptor binding1.86e-021.00e+005.7391615
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.86e-021.00e+005.7391315
GO:0001824blastocyst development1.86e-021.00e+005.7391215
GO:0043982histone H4-K8 acetylation1.86e-021.00e+005.7391515
GO:0006376mRNA splice site selection1.86e-021.00e+005.7391115
GO:0016607nuclear speck1.91e-021.00e+003.220212172
GO:0043274phospholipase binding1.98e-021.00e+005.6461116
GO:0042176regulation of protein catabolic process1.98e-021.00e+005.6461216
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription1.98e-021.00e+005.6461216
GO:0022624proteasome accessory complex2.10e-021.00e+005.5591117
GO:0043984histone H4-K16 acetylation2.35e-021.00e+005.3981519
GO:0014003oligodendrocyte development2.47e-021.00e+005.3241520
GO:0043393regulation of protein binding2.47e-021.00e+005.3241120
GO:0000123histone acetyltransferase complex2.59e-021.00e+005.2541621
GO:0045787positive regulation of cell cycle2.71e-021.00e+005.1871222
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription2.71e-021.00e+005.1871422
GO:0030864cortical actin cytoskeleton2.83e-021.00e+005.1231123
GO:0006362transcription elongation from RNA polymerase I promoter2.83e-021.00e+005.1231123
GO:0006363termination of RNA polymerase I transcription2.95e-021.00e+005.0611124
GO:0006355regulation of transcription, DNA-templated3.18e-021.00e+001.685443997
GO:0035329hippo signaling3.20e-021.00e+004.9461526
GO:0006361transcription initiation from RNA polymerase I promoter3.20e-021.00e+004.9461126
GO:0046966thyroid hormone receptor binding3.20e-021.00e+004.9461626
GO:0006412translation3.28e-021.00e+002.80128230
GO:0071339MLL1 complex3.32e-021.00e+004.8911627
GO:0003727single-stranded RNA binding3.44e-021.00e+004.8391228
GO:0030901midbrain development3.56e-021.00e+004.7881129
GO:0045087innate immune response3.61e-021.00e+002.012315596
GO:0044822poly(A) RNA binding3.83e-021.00e+001.6024501056
GO:1903507negative regulation of nucleic acid-templated transcription3.92e-021.00e+004.6461232
GO:0000166nucleotide binding4.07e-021.00e+002.629213259
GO:0030178negative regulation of Wnt signaling pathway4.28e-021.00e+004.5171435
GO:0035019somatic stem cell maintenance4.88e-021.00e+004.3241640
GO:0050885neuromuscular process controlling balance4.88e-021.00e+004.3241240
GO:0030521androgen receptor signaling pathway5.00e-021.00e+004.2891541
GO:0016020membrane5.01e-021.00e+001.2535461681
GO:0006418tRNA aminoacylation for protein translation5.12e-021.00e+004.2541342
GO:0031124mRNA 3'-end processing5.12e-021.00e+004.2541242
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity5.24e-021.00e+004.2201743
GO:0003712transcription cofactor activity5.35e-021.00e+004.1871844
GO:0006369termination of RNA polymerase II transcription5.47e-021.00e+004.1541245
GO:0030900forebrain development5.95e-021.00e+004.0311149
GO:0006521regulation of cellular amino acid metabolic process6.06e-021.00e+004.0021150
GO:0003682chromatin binding6.18e-021.00e+002.293219327
GO:0009611response to wounding6.30e-021.00e+003.9461552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding6.42e-021.00e+003.9181553
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay6.42e-021.00e+003.9181453
GO:0000932cytoplasmic mRNA processing body6.53e-021.00e+003.8911454
GO:0003723RNA binding6.68e-021.00e+002.228218342
GO:0008203cholesterol metabolic process6.88e-021.00e+003.8131257
GO:0000502proteasome complex7.00e-021.00e+003.7881358
GO:0045944positive regulation of transcription from RNA polymerase II promoter7.21e-021.00e+001.607341789
GO:0008013beta-catenin binding7.23e-021.00e+003.7391960
GO:0006406mRNA export from nucleus7.35e-021.00e+003.7151461
GO:0030141secretory granule7.47e-021.00e+003.6921462
GO:0004867serine-type endopeptidase inhibitor activity7.58e-021.00e+003.6691363
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest7.70e-021.00e+003.6461164
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.81e-021.00e+003.6241265
GO:0010468regulation of gene expression8.16e-021.00e+003.5591268
GO:0003697single-stranded DNA binding8.16e-021.00e+003.5591568
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle8.39e-021.00e+003.5171270
GO:0007626locomotory behavior8.50e-021.00e+003.4961271
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent8.62e-021.00e+003.4761172
GO:0003729mRNA binding8.62e-021.00e+003.4761472
GO:0001843neural tube closure8.85e-021.00e+003.4371274
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity8.85e-021.00e+003.4371474
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle8.85e-021.00e+003.4371274
GO:0008584male gonad development8.96e-021.00e+003.4171375
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I8.96e-021.00e+003.4171175
GO:0060070canonical Wnt signaling pathway8.96e-021.00e+003.4171475
GO:0005179hormone activity9.42e-021.00e+003.3421179
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process9.42e-021.00e+003.3421279
GO:0009653anatomical structure morphogenesis9.87e-021.00e+003.2711283
GO:0050821protein stabilization1.04e-011.00e+003.1871388
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.09e-011.00e+003.1231192
GO:0044267cellular protein metabolic process1.17e-011.00e+001.757220474
GO:0042802identical protein binding1.21e-011.00e+001.727219484
GO:0010951negative regulation of endopeptidase activity1.22e-011.00e+002.94616104
GO:0000209protein polyubiquitination1.35e-011.00e+002.78813116
GO:0006325chromatin organization1.38e-011.00e+002.764112118
GO:0008201heparin binding1.42e-011.00e+002.71511122
GO:0007507heart development1.60e-011.00e+002.52717139
GO:0010628positive regulation of gene expression1.67e-011.00e+002.45617146
GO:0000082G1/S transition of mitotic cell cycle1.71e-011.00e+002.42713149
GO:0042981regulation of apoptotic process1.72e-011.00e+002.41714150
GO:0006974cellular response to DNA damage stimulus1.73e-011.00e+002.40817151
GO:0008022protein C-terminus binding1.83e-011.00e+002.31518161
GO:0034641cellular nitrogen compound metabolic process1.93e-011.00e+002.22812171
GO:0007049cell cycle1.96e-011.00e+002.20316174
GO:0005667transcription factor complex1.97e-011.00e+002.195117175
GO:0031625ubiquitin protein ligase binding2.00e-011.00e+002.17015178
GO:0003714transcription corepressor activity2.00e-011.00e+002.170111178
GO:0019904protein domain specific binding2.01e-011.00e+002.16218179
GO:0004872receptor activity2.11e-011.00e+002.08418189
GO:0003700sequence-specific DNA binding transcription factor activity2.16e-011.00e+001.197239699
GO:0003924GTPase activity2.19e-011.00e+002.02417197
GO:0001701in utero embryonic development2.23e-011.00e+001.99518201
GO:0006184GTP catabolic process2.36e-011.00e+001.90517214
GO:0016071mRNA metabolic process2.45e-011.00e+001.84518223
GO:0008134transcription factor binding2.63e-011.00e+001.727118242
GO:0043025neuronal cell body2.66e-011.00e+001.71019245
GO:0016070RNA metabolic process2.67e-011.00e+001.69818247
GO:0006357regulation of transcription from RNA polymerase II promoter2.83e-011.00e+001.602123264
GO:0003779actin binding2.85e-011.00e+001.591110266
GO:0030198extracellular matrix organization3.00e-011.00e+001.50216283
GO:0007186G-protein coupled receptor signaling pathway3.05e-011.00e+001.47111289
GO:0005525GTP binding3.24e-011.00e+001.370112310
GO:0008283cell proliferation3.39e-011.00e+001.289114328
GO:0043565sequence-specific DNA binding3.54e-011.00e+001.212111346
GO:0005925focal adhesion3.71e-011.00e+001.13019366
GO:0000278mitotic cell cycle3.90e-011.00e+001.035115391
GO:0043066negative regulation of apoptotic process4.16e-011.00e+000.918116424
GO:0045893positive regulation of transcription, DNA-templated4.55e-011.00e+000.745124478
GO:0006915apoptotic process5.07e-011.00e+000.530112555
GO:0000122negative regulation of transcription from RNA polymerase II promoter5.16e-011.00e+000.491137570
GO:0005737cytoplasm5.25e-011.00e+000.08951243767
GO:0070062extracellular vesicular exosome5.96e-011.00e+000.0023572400
GO:0005730nucleolus6.24e-011.00e+00-0.0342661641
GO:0005576extracellular region7.04e-011.00e+00-0.233113942
GO:0005739mitochondrion7.25e-011.00e+00-0.317123998
GO:0008270zinc ion binding7.25e-011.00e+00-0.315127997
GO:0044281small molecule metabolic process7.94e-011.00e+00-0.5961201211
GO:0005524ATP binding8.17e-011.00e+00-0.6961311298
GO:0046872metal ion binding8.19e-011.00e+00-0.7061291307
GO:0006351transcription, DNA-templated8.51e-011.00e+00-0.8521571446
GO:0005886plasma membrane8.59e-011.00e+00-0.6882492582
GO:0016021integral component of membrane9.30e-011.00e+00-1.3071171982