int-snw-1029

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.959	7.22e-17	1.01e-04	1.12e-03

chia-screen-data-Fav-int-snw-1029 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
FTSJ1	24140	4	-2.463	2.994	95	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
GSPT1	2935	1	-2.313	2.959	30	Yes	Yes
ETF1	2107	3	-2.829	2.959	71	Yes	Yes
NFRKB	4798	48	-3.129	3.108	23	Yes	Yes
YY1	7528	24	-2.572	3.120	114	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
[ CDKN2A ]	1029	2	-1.774	2.959	126	-	-
E4F1	1877	1	-2.370	2.959	27	Yes	Yes

Interactions (11)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
NFRKB	4798	YY1	7528	pp	--	int.I2D: BioGrid
CDKN2A	1029	GSPT1	2935	pp	--	int.I2D: BCI; int.HPRD: in vitro, in vivo, yeast 2-hybrid
CDKN2A	1029	E4F1	1877	pp	--	int.I2D: BioGrid; int.HPRD: in vivo
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
ETF1	2107	GSPT1	2935	pp	--	int.I2D: MINT, BCI, BioGrid, HPRD; int.Mint: MI:0915(physical association); int.HPRD: in vivo, yeast 2-hybrid
NFRKB	4798	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
CDKN2A	1029	YY1	7528	pp	--	int.I2D: BioGrid, BIND, BCI
CDKN2A	1029	HNRNPU	3192	pp	--	int.Intact: MI:0915(physical association)
CDKN2A	1029	FTSJ1	24140	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (184)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0003747	translation release factor activity	3.17e-06	4.57e-02	9.357	2	2	4
GO:0044212	transcription regulatory region DNA binding	5.50e-06	7.93e-02	4.964	4	17	168
GO:0003714	transcription corepressor activity	6.92e-06	9.98e-02	4.881	4	11	178
GO:0003677	DNA binding	7.34e-06	1.06e-01	2.914	7	49	1218
GO:0042789	mRNA transcription from RNA polymerase II promoter	4.11e-05	5.92e-01	7.656	2	2	13
GO:0006479	protein methylation	4.79e-05	6.91e-01	7.549	2	2	14
GO:0031011	Ino80 complex	4.79e-05	6.91e-01	7.549	2	6	14
GO:0005654	nucleoplasm	5.85e-05	8.43e-01	2.862	6	64	1082
GO:0006974	cellular response to DNA damage stimulus	1.75e-04	1.00e+00	4.703	3	7	151
GO:0003713	transcription coactivator activity	6.56e-04	1.00e+00	4.053	3	24	237
GO:0044822	poly(A) RNA binding	6.63e-04	1.00e+00	2.634	5	50	1056
GO:0008134	transcription factor binding	6.97e-04	1.00e+00	4.023	3	18	242
GO:0060795	cell fate commitment involved in formation of primary germ layer	7.63e-04	1.00e+00	10.357	1	1	1
GO:0002128	tRNA nucleoside ribose methylation	7.63e-04	1.00e+00	10.357	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	7.63e-04	1.00e+00	10.357	1	1	1
GO:0008079	translation termination factor activity	7.63e-04	1.00e+00	10.357	1	1	1
GO:0009794	regulation of mitotic cell cycle, embryonic	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	7.63e-04	1.00e+00	10.357	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	7.63e-04	1.00e+00	10.357	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	7.63e-04	1.00e+00	10.357	1	1	1
GO:0005515	protein binding	1.10e-03	1.00e+00	1.122	10	198	6024
GO:0003700	sequence-specific DNA binding transcription factor activity	1.37e-03	1.00e+00	2.908	4	39	699
GO:0034696	response to prostaglandin F	1.52e-03	1.00e+00	9.357	1	1	2
GO:0060242	contact inhibition	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006403	RNA localization	1.52e-03	1.00e+00	9.357	1	1	2
GO:0008175	tRNA methyltransferase activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0009786	regulation of asymmetric cell division	1.52e-03	1.00e+00	9.357	1	1	2
GO:0055105	ubiquitin-protein transferase inhibitor activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.52e-03	1.00e+00	9.357	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.52e-03	1.00e+00	9.357	1	1	2
GO:0003723	RNA binding	1.89e-03	1.00e+00	3.524	3	18	342
GO:0006415	translational termination	1.91e-03	1.00e+00	4.914	2	2	87
GO:0016149	translation release factor activity, codon specific	2.29e-03	1.00e+00	8.772	1	1	3
GO:0035985	senescence-associated heterochromatin focus	2.29e-03	1.00e+00	8.772	1	1	3
GO:0035986	senescence-associated heterochromatin focus assembly	2.29e-03	1.00e+00	8.772	1	1	3
GO:0060913	cardiac cell fate determination	2.29e-03	1.00e+00	8.772	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.29e-03	1.00e+00	8.772	1	1	3
GO:2000111	positive regulation of macrophage apoptotic process	2.29e-03	1.00e+00	8.772	1	1	3
GO:2000774	positive regulation of cellular senescence	3.05e-03	1.00e+00	8.357	1	1	4
GO:0033088	negative regulation of immature T cell proliferation in thymus	3.05e-03	1.00e+00	8.357	1	1	4
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	3.25e-03	1.00e+00	4.524	2	4	114
GO:0001714	endodermal cell fate specification	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.81e-03	1.00e+00	8.035	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.81e-03	1.00e+00	8.035	1	2	5
GO:1902510	regulation of apoptotic DNA fragmentation	3.81e-03	1.00e+00	8.035	1	1	5
GO:0006449	regulation of translational termination	3.81e-03	1.00e+00	8.035	1	1	5
GO:0034393	positive regulation of smooth muscle cell apoptotic process	3.81e-03	1.00e+00	8.035	1	2	5
GO:0097371	MDM2/MDM4 family protein binding	3.81e-03	1.00e+00	8.035	1	1	5
GO:0007050	cell cycle arrest	3.83e-03	1.00e+00	4.402	2	5	124
GO:0010564	regulation of cell cycle process	4.57e-03	1.00e+00	7.772	1	1	6
GO:0002181	cytoplasmic translation	4.57e-03	1.00e+00	7.772	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	4.57e-03	1.00e+00	7.772	1	3	6
GO:0035497	cAMP response element binding	4.57e-03	1.00e+00	7.772	1	1	6
GO:0006355	regulation of transcription, DNA-templated	5.05e-03	1.00e+00	2.395	4	43	997
GO:0046825	regulation of protein export from nucleus	5.33e-03	1.00e+00	7.549	1	2	7
GO:0051444	negative regulation of ubiquitin-protein transferase activity	5.33e-03	1.00e+00	7.549	1	1	7
GO:0000082	G1/S transition of mitotic cell cycle	5.48e-03	1.00e+00	4.137	2	3	149
GO:0010389	regulation of G2/M transition of mitotic cell cycle	6.09e-03	1.00e+00	7.357	1	1	8
GO:0001955	blood vessel maturation	6.09e-03	1.00e+00	7.357	1	1	8
GO:0005634	nucleus	6.13e-03	1.00e+00	1.202	8	159	4559
GO:0010225	response to UV-C	6.85e-03	1.00e+00	7.187	1	2	9
GO:0006983	ER overload response	6.85e-03	1.00e+00	7.187	1	1	9
GO:0048103	somatic stem cell division	6.85e-03	1.00e+00	7.187	1	1	9
GO:0000400	four-way junction DNA binding	6.85e-03	1.00e+00	7.187	1	1	9
GO:0005667	transcription factor complex	7.49e-03	1.00e+00	3.905	2	17	175
GO:0035413	positive regulation of catenin import into nucleus	7.60e-03	1.00e+00	7.035	1	2	10
GO:0071850	mitotic cell cycle arrest	7.60e-03	1.00e+00	7.035	1	1	10
GO:0090399	replicative senescence	7.60e-03	1.00e+00	7.035	1	1	10
GO:0033235	positive regulation of protein sumoylation	8.36e-03	1.00e+00	6.897	1	1	11
GO:0045662	negative regulation of myoblast differentiation	8.36e-03	1.00e+00	6.897	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	8.36e-03	1.00e+00	6.897	1	4	11
GO:0001953	negative regulation of cell-matrix adhesion	9.12e-03	1.00e+00	6.772	1	2	12
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	9.12e-03	1.00e+00	6.772	1	2	12
GO:0035198	miRNA binding	9.12e-03	1.00e+00	6.772	1	1	12
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	9.12e-03	1.00e+00	6.772	1	1	12
GO:0071480	cellular response to gamma radiation	9.87e-03	1.00e+00	6.656	1	1	13
GO:0030889	negative regulation of B cell proliferation	9.87e-03	1.00e+00	6.656	1	1	13
GO:0001824	blastocyst development	1.14e-02	1.00e+00	6.450	1	2	15
GO:0051276	chromosome organization	1.21e-02	1.00e+00	6.357	1	2	16
GO:0048593	camera-type eye morphogenesis	1.21e-02	1.00e+00	6.357	1	1	16
GO:0010467	gene expression	1.24e-02	1.00e+00	2.556	3	45	669
GO:0090398	cellular senescence	1.36e-02	1.00e+00	6.187	1	1	18
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	1.44e-02	1.00e+00	6.109	1	2	19
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	1.44e-02	1.00e+00	6.109	1	2	19
GO:0071158	positive regulation of cell cycle arrest	1.44e-02	1.00e+00	6.109	1	2	19
GO:0032757	positive regulation of interleukin-8 production	1.52e-02	1.00e+00	6.035	1	1	20
GO:0042326	negative regulation of phosphorylation	1.59e-02	1.00e+00	5.964	1	1	21
GO:0008637	apoptotic mitochondrial changes	1.59e-02	1.00e+00	5.964	1	2	21
GO:0031648	protein destabilization	1.59e-02	1.00e+00	5.964	1	1	21
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	2	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.74e-02	1.00e+00	5.833	1	1	23
GO:0051059	NF-kappaB binding	1.89e-02	1.00e+00	5.713	1	3	25
GO:0031519	PcG protein complex	1.89e-02	1.00e+00	5.713	1	1	25
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.93e-02	1.00e+00	2.318	3	41	789
GO:0035329	hippo signaling	1.97e-02	1.00e+00	5.656	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.97e-02	1.00e+00	5.656	1	1	26
GO:0043022	ribosome binding	2.04e-02	1.00e+00	5.602	1	1	27
GO:0034644	cellular response to UV	2.27e-02	1.00e+00	5.450	1	1	30
GO:0031647	regulation of protein stability	2.27e-02	1.00e+00	5.450	1	4	30
GO:0070534	protein K63-linked ubiquitination	2.34e-02	1.00e+00	5.402	1	1	31
GO:0016604	nuclear body	2.34e-02	1.00e+00	5.402	1	3	31
GO:0042594	response to starvation	2.34e-02	1.00e+00	5.402	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	2.41e-02	1.00e+00	5.357	1	2	32
GO:0008283	cell proliferation	2.48e-02	1.00e+00	2.999	2	14	328
GO:0043565	sequence-specific DNA binding	2.74e-02	1.00e+00	2.922	2	11	346
GO:0005829	cytosol	2.85e-02	1.00e+00	1.393	5	86	2496
GO:0035019	somatic stem cell maintenance	3.01e-02	1.00e+00	5.035	1	6	40
GO:0043525	positive regulation of neuron apoptotic process	3.45e-02	1.00e+00	4.833	1	4	46
GO:0006986	response to unfolded protein	3.75e-02	1.00e+00	4.713	1	4	50
GO:0040008	regulation of growth	3.75e-02	1.00e+00	4.713	1	2	50
GO:0045892	negative regulation of transcription, DNA-templated	3.79e-02	1.00e+00	2.667	2	24	413
GO:0034976	response to endoplasmic reticulum stress	3.82e-02	1.00e+00	4.684	1	2	51
GO:0045454	cell redox homeostasis	3.82e-02	1.00e+00	4.684	1	1	51
GO:0006366	transcription from RNA polymerase II promoter	3.89e-02	1.00e+00	2.646	2	30	419
GO:0009611	response to wounding	3.90e-02	1.00e+00	4.656	1	5	52
GO:0000724	double-strand break repair via homologous recombination	4.12e-02	1.00e+00	4.575	1	2	55
GO:0002039	p53 binding	4.12e-02	1.00e+00	4.575	1	4	55
GO:0005737	cytoplasm	4.20e-02	1.00e+00	1.062	6	124	3767
GO:0006396	RNA processing	4.41e-02	1.00e+00	4.474	1	5	59
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	4.41e-02	1.00e+00	4.474	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	4.41e-02	1.00e+00	4.474	1	6	59
GO:0006987	activation of signaling protein activity involved in unfolded protein response	4.56e-02	1.00e+00	4.426	1	2	61
GO:0032088	negative regulation of NF-kappaB transcription factor activity	4.70e-02	1.00e+00	4.379	1	3	63
GO:0006310	DNA recombination	4.85e-02	1.00e+00	4.334	1	7	65
GO:0006469	negative regulation of protein kinase activity	4.85e-02	1.00e+00	4.334	1	4	65
GO:0044267	cellular protein metabolic process	4.87e-02	1.00e+00	2.468	2	20	474
GO:0045893	positive regulation of transcription, DNA-templated	4.95e-02	1.00e+00	2.456	2	24	478
GO:0010468	regulation of gene expression	5.07e-02	1.00e+00	4.269	1	2	68
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	5.29e-02	1.00e+00	4.207	1	4	71
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.50e-02	1.00e+00	4.147	1	4	74
GO:0002020	protease binding	5.50e-02	1.00e+00	4.147	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.58e-02	1.00e+00	4.128	1	1	75
GO:0007265	Ras protein signal transduction	5.58e-02	1.00e+00	4.128	1	3	75
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	5.72e-02	1.00e+00	4.090	1	3	77
GO:0071013	catalytic step 2 spliceosome	5.79e-02	1.00e+00	4.071	1	7	78
GO:0030968	endoplasmic reticulum unfolded protein response	5.86e-02	1.00e+00	4.053	1	2	79
GO:0009653	anatomical structure morphogenesis	6.15e-02	1.00e+00	3.982	1	2	83
GO:0009952	anterior/posterior pattern specification	6.15e-02	1.00e+00	3.982	1	4	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	6.37e-02	1.00e+00	3.930	1	8	86
GO:0050821	protein stabilization	6.51e-02	1.00e+00	3.897	1	3	88
GO:0016363	nuclear matrix	6.73e-02	1.00e+00	3.849	1	6	91
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	6.77e-02	1.00e+00	2.202	2	37	570
GO:0001649	osteoblast differentiation	6.80e-02	1.00e+00	3.833	1	5	92
GO:0005770	late endosome	6.87e-02	1.00e+00	3.817	1	2	93
GO:0006364	rRNA processing	6.94e-02	1.00e+00	3.802	1	3	94
GO:0030308	negative regulation of cell growth	8.08e-02	1.00e+00	3.575	1	6	110
GO:0030529	ribonucleoprotein complex	8.22e-02	1.00e+00	3.549	1	5	112
GO:0005819	spindle	8.22e-02	1.00e+00	3.549	1	1	112
GO:0000209	protein polyubiquitination	8.50e-02	1.00e+00	3.499	1	3	116
GO:0006260	DNA replication	8.85e-02	1.00e+00	3.438	1	3	121
GO:0006351	transcription, DNA-templated	9.00e-02	1.00e+00	1.444	3	57	1446
GO:0016055	Wnt signaling pathway	1.00e-01	1.00e+00	3.248	1	4	138
GO:0000398	mRNA splicing, via spliceosome	1.18e-01	1.00e+00	2.999	1	15	164
GO:0005730	nucleolus	1.21e-01	1.00e+00	1.261	3	66	1641
GO:0031625	ubiquitin protein ligase binding	1.28e-01	1.00e+00	2.881	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	1.32e-01	1.00e+00	2.833	1	22	184
GO:0003924	GTPase activity	1.40e-01	1.00e+00	2.735	1	7	197
GO:0005622	intracellular	1.47e-01	1.00e+00	2.663	1	6	207
GO:0006184	GTP catabolic process	1.52e-01	1.00e+00	2.615	1	7	214
GO:0016874	ligase activity	1.52e-01	1.00e+00	2.615	1	4	214
GO:0016071	mRNA metabolic process	1.58e-01	1.00e+00	2.556	1	8	223
GO:0007067	mitotic nuclear division	1.60e-01	1.00e+00	2.530	1	6	227
GO:0008380	RNA splicing	1.61e-01	1.00e+00	2.524	1	22	228
GO:0006412	translation	1.62e-01	1.00e+00	2.511	1	8	230
GO:0016070	RNA metabolic process	1.73e-01	1.00e+00	2.408	1	8	247
GO:0006281	DNA repair	1.82e-01	1.00e+00	2.329	1	14	261
GO:0007283	spermatogenesis	1.83e-01	1.00e+00	2.323	1	3	262
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.84e-01	1.00e+00	2.312	1	23	264
GO:0006954	inflammatory response	1.92e-01	1.00e+00	2.243	1	6	277
GO:0043234	protein complex	2.03e-01	1.00e+00	2.152	1	11	295
GO:0016567	protein ubiquitination	2.03e-01	1.00e+00	2.152	1	4	295
GO:0030154	cell differentiation	2.07e-01	1.00e+00	2.123	1	5	301
GO:0005525	GTP binding	2.13e-01	1.00e+00	2.081	1	12	310
GO:0019901	protein kinase binding	2.17e-01	1.00e+00	2.048	1	18	317
GO:0008285	negative regulation of cell proliferation	2.39e-01	1.00e+00	1.893	1	10	353
GO:0046982	protein heterodimerization activity	2.55e-01	1.00e+00	1.787	1	8	380
GO:0000278	mitotic cell cycle	2.61e-01	1.00e+00	1.746	1	15	391
GO:0009986	cell surface	2.67e-01	1.00e+00	1.706	1	9	402
GO:0016032	viral process	3.40e-01	1.00e+00	1.296	1	26	534
GO:0008270	zinc ion binding	5.45e-01	1.00e+00	0.395	1	27	997
GO:0005739	mitochondrion	5.46e-01	1.00e+00	0.394	1	23	998
GO:0005524	ATP binding	6.46e-01	1.00e+00	0.015	1	31	1298
GO:0046872	metal ion binding	6.48e-01	1.00e+00	0.005	1	29	1307
GO:0016020	membrane	7.44e-01	1.00e+00	-0.358	1	46	1681

chia-Fav

int-snw-1029

Statistics

Genes (11)

Interactions (11)

Related GO terms (184)