meta-reg-snw-5887

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
int-snw-51477 wolf-screen-ratio-mammosphere-adherent 0.934 1.79e-15 2.53e-03 4.07e-02 9 8
reg-snw-5887 wolf-screen-ratio-mammosphere-adherent 0.858 2.95e-07 1.57e-03 3.19e-03 5 5
int-snw-2064 wolf-screen-ratio-mammosphere-adherent 0.950 4.36e-16 1.79e-03 3.17e-02 15 15
int-snw-5216 wolf-screen-ratio-mammosphere-adherent 1.002 3.25e-18 5.25e-04 1.26e-02 12 11
int-snw-1120 wolf-screen-ratio-mammosphere-adherent 0.934 1.80e-15 2.53e-03 4.08e-02 16 15
int-snw-5743 wolf-screen-ratio-mammosphere-adherent 0.944 7.33e-16 2.03e-03 3.48e-02 12 11
int-snw-6446 wolf-screen-ratio-mammosphere-adherent 0.930 2.55e-15 2.75e-03 4.33e-02 18 18
wolf-screen-ratio-mammosphere-adherent-meta-reg-snw-5887 subnetwork

Genes (37)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
PSMA2 5683 1121.0931.106108Yes-
TP53 7157 230.4320.833665--
ERBB2 2064 100.0040.950156Yes-
VARS 7407 860.5491.002204Yes-
CHKB 1120 12-0.1690.93442-Yes
ISYNA1 51477 3-0.1200.93448--
ATP6V1B2 526 530.8811.076278--
RPA2 6118 961.2501.15176Yes-
PSMA6 5687 190.6910.956137Yes-
PSMD1 5707 860.8360.830118Yes-
EIF2S2 8894 391.0750.940103Yes-
EEF2 1938 640.8901.043301Yes-
PFN1 5216 10-0.1431.00278--
RPS11 6205 620.9931.113175Yes-
RAD23B 5887 70.1580.85811Yes-
EFTUD2 9343 930.8830.956108Yes-
SGK1 6446 17-0.1890.93076-Yes
TUBG1 7283 980.9740.97391Yes-
PSMD11 5717 1241.0951.106218Yes-
KPNB1 3837 170.6131.017296Yes-
ITK 3702 150.6020.95039Yes-
RBX1 9978 1151.1850.934148Yes-
PSMB7 5695 1180.9820.93490Yes-
PSMA1 5682 1000.9960.878152Yes-
RPSA 3921 1201.3271.151152Yes-
RPS3A 6189 400.8351.069166Yes-
PGD 5226 891.2011.106152Yes-
PTGS2 5743 11-0.2420.94414-Yes
ACO2 50 651.0001.076191Yes-
CDC16 8881 530.9501.02080Yes-
PSMD3 5709 1000.9861.106201Yes-
CLTC 1213 560.8841.138247Yes-
RPL14 9045 491.2501.113166Yes-
GSK3B 2932 220.4750.934319-Yes
ACTB 60 1341.1531.151610Yes-
SAP18 10284 201.1151.06957Yes-
PSMD6 9861 790.8480.878143Yes-

Interactions (113)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMD1 5707 RAD23B 5887 pp -- int.I2D: BioGrid_Yeast, IntAct_Rat, IntAct_Yeast, Krogan_Core, MINT, MINT_Yeast;
int.Mint: MI:0915(physical association)
PSMD11 5717 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, BioGrid, INTEROLOG
SGK1 6446 PSMD6 9861 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
EEF2 1938 PGD 5226 pp -- int.I2D: BioGrid_Yeast
RAD23B 5887 PSMD6 9861 pp -- int.I2D: MINT;
int.Mint: MI:0915(physical association)
PSMA6 5687 RBX1 9978 pp -- int.I2D: BioGrid
GSK3B 2932 TP53 7157 pp -- int.I2D: BIND, MINT, BCI, BioGrid, HPRD;
int.Mint: MI:0915(physical association), MI:0217(phosphorylation reaction);
int.HPRD: in vitro, in vivo
EEF2 1938 ISYNA1 51477 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, Tarassov_PCA, IntAct_Yeast
PSMD11 5717 RAD23B 5887 pp -- int.I2D: YeastLow, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast
PSMD1 5707 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, Krogan_Core
KPNB1 3837 TP53 7157 pp -- int.I2D: BioGrid, HPRD;
int.HPRD: in vivo
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
PFN1 5216 TP53 7157 pd < reg.ITFP.txt: no annot
ACTB 60 KPNB1 3837 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PSMB7 5695 RAD23B 5887 pp -- int.I2D: BioGrid_Yeast, BIND_Yeast, MIPS
GSK3B 2932 SGK1 6446 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vitro, in vivo
PSMA2 5683 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
PSMD3 5709 RAD23B 5887 pd > reg.ITFP.txt: no annot
PSMD3 5709 RAD23B 5887 pp -- int.I2D: YeastLow, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast
PTGS2 5743 TP53 7157 pp -- int.I2D: BioGrid, BIND, HPRD;
int.HPRD: in vivo
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
RPA2 6118 TP53 7157 pp -- int.Transfac: -
TP53 7157 EIF2S2 8894 pp -- int.Intact: MI:0915(physical association);
int.I2D: HPRD, IntAct, BioGrid, MINT, StelzlHigh;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
RPS3A 6189 PSMD6 9861 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMD6 9861 pd < reg.ITFP.txt: no annot
PSMA1 5682 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, YeastMedium
RPSA 3921 VARS 7407 pp -- int.I2D: IntAct_Yeast
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMD1 5707 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast
ATP6V1B2 526 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 EEF2 1938 pp -- int.I2D: YeastLow, IntAct_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
PSMD11 5717 TP53 7157 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, MINT, StelzlHigh, HPRD, IntAct;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
GSK3B 2932 TUBG1 7283 pp -- int.I2D: MINT
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
CLTC 1213 EIF2S2 8894 pp -- int.I2D: YeastLow
TUBG1 7283 VARS 7407 pd < reg.ITFP.txt: no annot
PSMA2 5683 PSMA6 5687 pp -- int.Intact: MI:0914(association), MI:0915(physical association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, HPRD, Krogan_Core, Tarassov_PCA, Yu_GoldStd;
int.HPRD: yeast 2-hybrid
ATP6V1B2 526 CHKB 1120 pp -- int.I2D: IntAct_Yeast
EEF2 1938 TP53 7157 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vivo
CHKB 1120 PSMD3 5709 pp -- int.I2D: IntAct_Yeast
CHKB 1120 GSK3B 2932 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow
SGK1 6446 VARS 7407 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
EEF2 1938 RAD23B 5887 pp -- int.I2D: Krogan_NonCore
RPS3A 6189 SAP18 10284 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid, HPRD, MINT;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
RAD23B 5887 RPS3A 6189 pp -- int.I2D: BIND_Yeast, MINT_Yeast, MIPS, IntAct_Yeast, YeastLow
RPS3A 6189 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
EEF2 1938 PSMD3 5709 pp -- int.I2D: Krogan_NonCore
PSMA6 5687 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMB7 5695 RBX1 9978 pd < reg.ITFP.txt: no annot
ACTB 60 ERBB2 2064 pp -- int.Intact: MI:0915(physical association), MI:0403(colocalization), MI:0914(association)
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
PSMD3 5709 TUBG1 7283 pd > reg.ITFP.txt: no annot
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
KPNB1 3837 PSMA2 5683 pp -- int.I2D: Krogan_NonCore, YeastLow
ATP6V1B2 526 CDC16 8881 pp -- int.I2D: IntAct_Yeast
PSMD1 5707 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, IntAct, Krogan_Core
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
CLTC 1213 PFN1 5216 pp -- int.I2D: BioGrid_Mouse
PGD 5226 PSMD3 5709 pp -- int.I2D: YeastLow
PSMA6 5687 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMD3 5709 PSMD6 9861 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, IntAct, IntAct_Yeast, MINT_Worm, MINT_Yeast, YeastHigh, BioGrid, BIND_Yeast, IntAct_Worm, INTEROLOG, Krogan_Core, MIPS
CLTC 1213 KPNB1 3837 pp -- int.Intact: MI:0914(association)
ACO2 50 KPNB1 3837 pp -- int.I2D: IntAct_Yeast
RPS3A 6189 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
PTGS2 5743 RBX1 9978 pp -- int.I2D: BioGrid
ACTB 60 PSMD6 9861 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
ERBB2 2064 KPNB1 3837 pp -- int.Intact: MI:0915(physical association), MI:0914(association), MI:0403(colocalization)
PSMD3 5709 VARS 7407 pd <> reg.ITFP.txt: no annot
ACTB 60 PSMA6 5687 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD1 5707 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA1 5682 PSMA6 5687 pp -- int.Intact: MI:0914(association), MI:0915(physical association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, YeastHigh, IntAct_Worm, Krogan_Core, MINT_Yeast;
int.Mint: MI:0914(association)
ACO2 50 ISYNA1 51477 pp -- int.I2D: BioGrid_Yeast
PSMD11 5717 TUBG1 7283 pd > reg.ITFP.txt: no annot
PSMA6 5687 SGK1 6446 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA1 5682 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RAD23B 5887 pp -- int.I2D: IntAct_Rat
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMB7 5695 PSMD6 9861 pd < reg.ITFP.txt: no annot
PSMB7 5695 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct
ACTB 60 PFN1 5216 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, BioGrid_Mouse, HPRD, MINT_Mouse, BCI, IntAct;
int.HPRD: in vitro;
int.DIP: MI:0407(direct interaction)
PSMD11 5717 EFTUD2 9343 pd > reg.ITFP.txt: no annot
KPNB1 3837 PSMA1 5682 pp -- int.I2D: YeastLow
ACO2 50 PGD 5226 pp -- int.I2D: YeastLow
ATP6V1B2 526 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 CDC16 8881 pp -- int.I2D: YeastLow
PSMD1 5707 PTGS2 5743 pp -- int.I2D: BioGrid, INNATEDB
ACTB 60 RPS3A 6189 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RPS3A 6189 SGK1 6446 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA6 5687 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast, BIND_Yeast, Krogan_Core, MINT_Yeast, YeastLow
GSK3B 2932 EFTUD2 9343 pp -- int.I2D: BioGrid, MINT;
int.Mint: MI:0915(physical association)
ERBB2 2064 ITK 3702 pp -- int.I2D: JonesErbB1, MINT;
int.Mint: MI:0407(direct interaction)
KPNB1 3837 PSMA6 5687 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, YeastLow, BioGrid
PSMA6 5687 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, YeastLow
PSMA6 5687 RAD23B 5887 pp -- int.I2D: Krogan_NonCore
ACTB 60 ATP6V1B2 526 pp -- int.I2D: BioGrid_Yeast
CLTC 1213 ISYNA1 51477 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, Tarassov_PCA, IntAct_Yeast
KPNB1 3837 PSMD11 5717 pp -- int.I2D: Krogan_NonCore
RPSA 3921 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMA6 5687 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMD11 5717 EIF2S2 8894 pd > reg.ITFP.txt: no annot
CLTC 1213 ERBB2 2064 pp -- int.Intact: MI:0914(association)

Related GO terms (632)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005829cytosol2.14e-183.49e-142.369301252562
GO:0000502proteasome complex5.44e-158.87e-116.09792258
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.61e-142.63e-105.93392265
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.61e-142.63e-105.93392465
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.26e-145.32e-105.82692470
GO:0016071mRNA metabolic process4.32e-147.04e-104.5691234223
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.50e-148.98e-105.74592474
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.02e-131.66e-095.65192579
GO:0016070RNA metabolic process1.46e-132.39e-094.4221234247
GO:0006521regulation of cellular amino acid metabolic process1.56e-132.54e-096.14182150
GO:0016032viral process2.46e-134.02e-093.6151555540
GO:0010467gene expression3.07e-135.01e-093.3991658669
GO:0042981regulation of apoptotic process9.57e-131.56e-084.8691026151
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent3.76e-126.13e-085.59582373
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I5.84e-129.54e-085.51882377
GO:0002474antigen processing and presentation of peptide antigen via MHC class I3.01e-114.91e-075.23082394
GO:0000082G1/S transition of mitotic cell cycle3.67e-115.99e-074.726933150
GO:0000209protein polyubiquitination1.66e-102.71e-064.927821116
GO:0005654nucleoplasm5.09e-108.30e-062.68816831095
GO:0000278mitotic cell cycle7.65e-101.25e-053.6081152398
GO:0043066negative regulation of apoptotic process1.85e-093.03e-053.4861130433
GO:0034641cellular nitrogen compound metabolic process4.82e-097.87e-054.317825177
GO:0006915apoptotic process3.26e-085.33e-043.0871134571
GO:0022624proteasome accessory complex5.21e-088.50e-046.6984917
GO:0005839proteasome core complex6.68e-081.09e-036.61541118
GO:0004298threonine-type endopeptidase activity1.06e-071.72e-036.46341120
GO:0070062extracellular vesicular exosome3.71e-076.05e-031.73619982516
GO:0044281small molecule metabolic process3.92e-076.40e-032.25414571295
GO:0019773proteasome core complex, alpha-subunit complex5.96e-079.73e-037.370358
GO:0006414translational elongation2.03e-063.32e-024.56851193
GO:0005838proteasome regulatory particle2.33e-063.80e-026.7853712
GO:0019058viral life cycle5.79e-069.46e-024.261510115
GO:0006413translational initiation1.09e-051.79e-014.073512131
GO:0006412translation1.34e-052.18e-013.493615235
GO:0044822poly(A) RNA binding1.72e-052.81e-012.17011501078
GO:0005844polysome2.38e-053.89e-015.7263425
GO:0019083viral transcription3.28e-055.36e-014.4454881
GO:0006415translational termination4.35e-057.10e-014.3424887
GO:0005515protein binding5.36e-058.75e-010.904261726127
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.74e-051.00e+004.08548104
GO:0022627cytosolic small ribosomal subunit9.27e-051.00e+005.0853339
GO:0044267cellular protein metabolic process1.06e-041.00e+002.641724495
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.25e-041.00e+003.952410114
GO:0030529ribonucleoprotein complex1.25e-041.00e+003.95248114
GO:0005634nucleus1.50e-041.00e+001.007221314828
GO:0006983ER overload response1.78e-041.00e+006.615229
GO:0003684damaged DNA binding2.07e-041.00e+004.69831151
GO:0010226response to lithium ion2.22e-041.00e+006.4632210
GO:0031571mitotic G1 DNA damage checkpoint2.72e-041.00e+006.3262311
GO:0003735structural constituent of ribosome2.83e-041.00e+003.64548141
GO:0016020membrane3.11e-041.00e+001.60012801746
GO:0032886regulation of microtubule-based process3.25e-041.00e+006.2002412
GO:0030234enzyme regulator activity3.84e-041.00e+006.0852313
GO:0019903protein phosphatase binding3.88e-041.00e+004.3933463
GO:0006289nucleotide-excision repair5.07e-041.00e+004.26131269
GO:0042176regulation of protein catabolic process5.88e-041.00e+005.7852316
GO:0031625ubiquitin protein ligase binding7.11e-041.00e+003.293413180
GO:0019901protein kinase binding7.31e-041.00e+002.785521320
GO:0005730nucleolus9.22e-041.00e+001.52711701684
GO:0000718nucleotide-excision repair, DNA damage removal1.02e-031.00e+005.3932521
GO:0003723RNA binding1.16e-031.00e+002.635519355
GO:0000060protein import into nucleus, translocation1.34e-031.00e+005.2002424
GO:0005925focal adhesion1.40e-031.00e+002.576518370
GO:0071456cellular response to hypoxia1.41e-031.00e+003.7553498
GO:0051059NF-kappaB binding1.45e-031.00e+005.1412325
GO:0090271positive regulation of fibroblast growth factor production2.27e-031.00e+008.785111
GO:0001042RNA polymerase I core binding2.27e-031.00e+008.785111
GO:0090362positive regulation of platelet-derived growth factor production2.27e-031.00e+008.785111
GO:0035639purine ribonucleoside triphosphate binding2.27e-031.00e+008.785111
GO:0019521D-gluconate metabolic process2.27e-031.00e+008.785111
GO:0004512inositol-3-phosphate synthase activity2.27e-031.00e+008.785111
GO:0060453regulation of gastric acid secretion2.27e-031.00e+008.785111
GO:0035633maintenance of blood-brain barrier2.27e-031.00e+008.785111
GO:0034644cellular response to UV2.38e-031.00e+004.7852532
GO:0033572transferrin transport2.38e-031.00e+004.7852632
GO:0001085RNA polymerase II transcription factor binding2.68e-031.00e+004.6982234
GO:0005524ATP binding2.68e-031.00e+001.5529461354
GO:0005737cytoplasm3.37e-031.00e+000.91517983976
GO:0006284base-excision repair3.51e-031.00e+004.5002739
GO:0019899enzyme binding3.97e-031.00e+002.615411288
GO:0051054positive regulation of DNA metabolic process4.53e-031.00e+007.785112
GO:0097252oligodendrocyte apoptotic process4.53e-031.00e+007.785112
GO:0003994aconitate hydratase activity4.53e-031.00e+007.785112
GO:0006407rRNA export from nucleus4.53e-031.00e+007.785112
GO:0071109superior temporal gyrus development4.53e-031.00e+007.785112
GO:2000077negative regulation of type B pancreatic cell development4.53e-031.00e+007.785112
GO:0090343positive regulation of cell aging4.53e-031.00e+007.785112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)4.53e-031.00e+007.785112
GO:0019322pentose biosynthetic process4.53e-031.00e+007.785112
GO:0004832valine-tRNA ligase activity4.53e-031.00e+007.785112
GO:0032227negative regulation of synaptic transmission, dopaminergic4.53e-031.00e+007.785112
GO:00515383 iron, 4 sulfur cluster binding4.53e-031.00e+007.785112
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic process4.53e-031.00e+007.785122
GO:1901525negative regulation of macromitophagy4.53e-031.00e+007.785112
GO:0002176male germ cell proliferation4.53e-031.00e+007.785112
GO:0004103choline kinase activity4.53e-031.00e+007.785112
GO:0000715nucleotide-excision repair, DNA damage recognition4.53e-031.00e+007.785112
GO:0006438valyl-tRNA aminoacylation4.53e-031.00e+007.785112
GO:0032633interleukin-4 production4.53e-031.00e+007.785112
GO:0005055laminin receptor activity4.53e-031.00e+007.785112
GO:0001865NK T cell differentiation4.53e-031.00e+007.785112
GO:0004666prostaglandin-endoperoxide synthase activity4.53e-031.00e+007.785112
GO:0043234protein complex4.58e-031.00e+002.556417300
GO:0045727positive regulation of translation4.86e-031.00e+004.2612446
GO:0050727regulation of inflammatory response5.07e-031.00e+004.2302347
GO:0038095Fc-epsilon receptor signaling pathway6.76e-031.00e+002.95237171
GO:0061574ASAP complex6.79e-031.00e+007.200113
GO:0014043negative regulation of neuron maturation6.79e-031.00e+007.200113
GO:0000320re-entry into mitotic cell cycle6.79e-031.00e+007.200113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity6.79e-031.00e+007.200113
GO:2000466negative regulation of glycogen (starch) synthase activity6.79e-031.00e+007.200113
GO:1900126negative regulation of hyaluronan biosynthetic process6.79e-031.00e+007.200113
GO:0035033histone deacetylase regulator activity6.79e-031.00e+007.200113
GO:0006021inositol biosynthetic process6.79e-031.00e+007.200113
GO:0002360T cell lineage commitment6.79e-031.00e+007.200113
GO:0009051pentose-phosphate shunt, oxidative branch6.79e-031.00e+007.200113
GO:0034103regulation of tissue remodeling6.79e-031.00e+007.200113
GO:0071942XPC complex6.79e-031.00e+007.200113
GO:0009750response to fructose6.79e-031.00e+007.200113
GO:0035794positive regulation of mitochondrial membrane permeability6.79e-031.00e+007.200113
GO:0051097negative regulation of helicase activity6.79e-031.00e+007.200113
GO:0005850eukaryotic translation initiation factor 2 complex6.79e-031.00e+007.200113
GO:0044027hypermethylation of CpG island6.79e-031.00e+007.200113
GO:0090336positive regulation of brown fat cell differentiation6.79e-031.00e+007.200113
GO:0071439clathrin complex6.79e-031.00e+007.200113
GO:0050473arachidonate 15-lipoxygenase activity6.79e-031.00e+007.200113
GO:0002039p53 binding6.89e-031.00e+004.0042755
GO:0005813centrosome7.04e-031.00e+002.380412339
GO:0000932cytoplasmic mRNA processing body7.13e-031.00e+003.9782356
GO:0008217regulation of blood pressure7.63e-031.00e+003.9272558
GO:0006302double-strand break repair8.68e-031.00e+003.8312862
GO:003068690S preribosome9.04e-031.00e+006.785114
GO:0070294renal sodium ion absorption9.04e-031.00e+006.785114
GO:0004305ethanolamine kinase activity9.04e-031.00e+006.785114
GO:0019788NEDD8 ligase activity9.04e-031.00e+006.785114
GO:0043125ErbB-3 class receptor binding9.04e-031.00e+006.785114
GO:0002326B cell lineage commitment9.04e-031.00e+006.785114
GO:0051534negative regulation of NFAT protein import into nucleus9.04e-031.00e+006.785114
GO:0033088negative regulation of immature T cell proliferation in thymus9.04e-031.00e+006.785114
GO:0032232negative regulation of actin filament bundle assembly9.04e-031.00e+006.785114
GO:0071782endoplasmic reticulum tubular network9.04e-031.00e+006.785114
GO:0000774adenyl-nucleotide exchange factor activity9.04e-031.00e+006.785114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)9.04e-031.00e+006.785114
GO:0000212meiotic spindle organization9.04e-031.00e+006.785114
GO:0032051clathrin light chain binding9.04e-031.00e+006.785114
GO:0090403oxidative stress-induced premature senescence9.04e-031.00e+006.785114
GO:0031467Cul7-RING ubiquitin ligase complex9.04e-031.00e+006.785114
GO:0006610ribosomal protein import into nucleus9.04e-031.00e+006.785114
GO:1903077negative regulation of protein localization to plasma membrane9.04e-031.00e+006.785114
GO:0071260cellular response to mechanical stimulus9.79e-031.00e+003.7412466
GO:0003697single-stranded DNA binding1.07e-021.00e+003.6762969
GO:0003924GTPase activity1.08e-021.00e+002.70539203
GO:1900029positive regulation of ruffle assembly1.13e-021.00e+006.463115
GO:0031622positive regulation of fever generation1.13e-021.00e+006.463125
GO:2000001regulation of DNA damage checkpoint1.13e-021.00e+006.463115
GO:0045986negative regulation of smooth muscle contraction1.13e-021.00e+006.463115
GO:0043248proteasome assembly1.13e-021.00e+006.463115
GO:0036016cellular response to interleukin-31.13e-021.00e+006.463115
GO:0030891VCB complex1.13e-021.00e+006.463125
GO:0017081chloride channel regulator activity1.13e-021.00e+006.463115
GO:0005827polar microtubule1.13e-021.00e+006.463115
GO:0032411positive regulation of transporter activity1.13e-021.00e+006.463115
GO:0031465Cul4B-RING E3 ubiquitin ligase complex1.13e-021.00e+006.463125
GO:0071636positive regulation of transforming growth factor beta production1.13e-021.00e+006.463115
GO:0097371MDM2/MDM4 family protein binding1.13e-021.00e+006.463115
GO:0031461cullin-RING ubiquitin ligase complex1.13e-021.00e+006.463115
GO:0031915positive regulation of synaptic plasticity1.13e-021.00e+006.463115
GO:2000738positive regulation of stem cell differentiation1.13e-021.00e+006.463115
GO:0006102isocitrate metabolic process1.13e-021.00e+006.463115
GO:0000730DNA recombinase assembly1.13e-021.00e+006.463135
GO:0031394positive regulation of prostaglandin biosynthetic process1.13e-021.00e+006.463115
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process1.28e-021.00e+003.5372376
GO:0006184GTP catabolic process1.34e-021.00e+002.58939220
GO:0010666positive regulation of cardiac muscle cell apoptotic process1.35e-021.00e+006.200116
GO:1902108regulation of mitochondrial membrane permeability involved in apoptotic process1.35e-021.00e+006.200116
GO:0002309T cell proliferation involved in immune response1.35e-021.00e+006.200116
GO:0006101citrate metabolic process1.35e-021.00e+006.200116
GO:0030118clathrin coat1.35e-021.00e+006.200116
GO:0010042response to manganese ion1.35e-021.00e+006.200116
GO:0070245positive regulation of thymocyte apoptotic process1.35e-021.00e+006.200116
GO:0010614negative regulation of cardiac muscle hypertrophy1.35e-021.00e+006.200116
GO:0002181cytoplasmic translation1.35e-021.00e+006.200116
GO:0030130clathrin coat of trans-Golgi network vesicle1.35e-021.00e+006.200116
GO:0031466Cul5-RING ubiquitin ligase complex1.35e-021.00e+006.200116
GO:0050774negative regulation of dendrite morphogenesis1.35e-021.00e+006.200116
GO:0030957Tat protein binding1.35e-021.00e+006.200146
GO:0007406negative regulation of neuroblast proliferation1.35e-021.00e+006.200116
GO:0045943positive regulation of transcription from RNA polymerase I promoter1.35e-021.00e+006.200116
GO:0031462Cul2-RING ubiquitin ligase complex1.58e-021.00e+005.978127
GO:0000028ribosomal small subunit assembly1.58e-021.00e+005.978117
GO:0002161aminoacyl-tRNA editing activity1.58e-021.00e+005.978127
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis1.58e-021.00e+005.978117
GO:0006657CDP-choline pathway1.58e-021.00e+005.978117
GO:0033180proton-transporting V-type ATPase, V1 domain1.58e-021.00e+005.978127
GO:0030132clathrin coat of coated pit1.58e-021.00e+005.978117
GO:0031497chromatin assembly1.58e-021.00e+005.978117
GO:0000930gamma-tubulin complex1.58e-021.00e+005.978117
GO:0047485protein N-terminus binding1.62e-021.00e+003.3592486
GO:0000733DNA strand renaturation1.80e-021.00e+005.785118
GO:0045116protein neddylation1.80e-021.00e+005.785128
GO:0045719negative regulation of glycogen biosynthetic process1.80e-021.00e+005.785118
GO:0030728ovulation1.80e-021.00e+005.785118
GO:0031464Cul4A-RING E3 ubiquitin ligase complex1.80e-021.00e+005.785128
GO:0070688MLL5-L complex1.80e-021.00e+005.785118
GO:1901030positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway1.80e-021.00e+005.785118
GO:0035372protein localization to microtubule1.80e-021.00e+005.785118
GO:0006928cellular component movement1.84e-021.00e+003.2612792
GO:0016363nuclear matrix1.84e-021.00e+003.26121192
GO:0016605PML body1.84e-021.00e+003.2612592
GO:0042470melanosome1.84e-021.00e+003.26121092
GO:0005200structural constituent of cytoskeleton1.88e-021.00e+003.2462793
GO:0001649osteoblast differentiation1.96e-021.00e+003.2152695
GO:0004716receptor signaling protein tyrosine kinase activity2.02e-021.00e+005.615119
GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process2.02e-021.00e+005.615119
GO:0031065positive regulation of histone deacetylation2.02e-021.00e+005.615119
GO:0008139nuclear localization sequence binding2.02e-021.00e+005.615129
GO:0008494translation activator activity2.02e-021.00e+005.615119
GO:0048156tau protein binding2.02e-021.00e+005.615119
GO:0032609interferon-gamma production2.02e-021.00e+005.615119
GO:0030837negative regulation of actin filament polymerization2.02e-021.00e+005.615119
GO:0007167enzyme linked receptor protein signaling pathway2.02e-021.00e+005.615119
GO:0006281DNA repair2.17e-021.00e+002.326322264
GO:0090399replicative senescence2.24e-021.00e+005.4631110
GO:0046902regulation of mitochondrial membrane permeability2.24e-021.00e+005.4631110
GO:0051497negative regulation of stress fiber assembly2.24e-021.00e+005.4631110
GO:0006450regulation of translational fidelity2.24e-021.00e+005.4631210
GO:0071318cellular response to ATP2.24e-021.00e+005.4631110
GO:0030877beta-catenin destruction complex2.24e-021.00e+005.4631210
GO:0043065positive regulation of apoptotic process2.39e-021.00e+002.27238274
GO:0045945positive regulation of transcription from RNA polymerase III promoter2.47e-021.00e+005.3261111
GO:0006693prostaglandin metabolic process2.47e-021.00e+005.3261111
GO:0006098pentose-phosphate shunt2.47e-021.00e+005.3261311
GO:0008340determination of adult lifespan2.47e-021.00e+005.3261111
GO:0010569regulation of double-strand break repair via homologous recombination2.47e-021.00e+005.3261111
GO:0071850mitotic cell cycle arrest2.47e-021.00e+005.3261111
GO:0042633hair cycle2.69e-021.00e+005.2001112
GO:0019372lipoxygenase pathway2.69e-021.00e+005.2001112
GO:0070266necroptotic process2.69e-021.00e+005.2001112
GO:0032461positive regulation of protein oligomerization2.69e-021.00e+005.2001112
GO:0009303rRNA transcription2.69e-021.00e+005.2001112
GO:0034236protein kinase A catalytic subunit binding2.69e-021.00e+005.2001112
GO:0050321tau-protein kinase activity2.69e-021.00e+005.2001112
GO:0005819spindle2.75e-021.00e+002.95227114
GO:0048015phosphatidylinositol-mediated signaling2.79e-021.00e+002.93923115
GO:0072562blood microparticle2.84e-021.00e+002.92724116
GO:0046827positive regulation of protein export from nucleus2.91e-021.00e+005.0851213
GO:0042273ribosomal large subunit biogenesis2.91e-021.00e+005.0851413
GO:0006646phosphatidylethanolamine biosynthetic process2.91e-021.00e+005.0851213
GO:0005662DNA replication factor A complex2.91e-021.00e+005.0851313
GO:0051926negative regulation of calcium ion transport2.91e-021.00e+005.0851113
GO:0031333negative regulation of protein complex assembly3.13e-021.00e+004.9781114
GO:0001516prostaglandin biosynthetic process3.13e-021.00e+004.9781114
GO:0006607NLS-bearing protein import into nucleus3.13e-021.00e+004.9781214
GO:0048168regulation of neuronal synaptic plasticity3.13e-021.00e+004.9781114
GO:0030330DNA damage response, signal transduction by p53 class mediator3.13e-021.00e+004.9781114
GO:0070542response to fatty acid3.13e-021.00e+004.9781114
GO:0035267NuA4 histone acetyltransferase complex3.13e-021.00e+004.9781414
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator3.13e-021.00e+004.9781214
GO:2000378negative regulation of reactive oxygen species metabolic process3.13e-021.00e+004.9781114
GO:0007020microtubule nucleation3.13e-021.00e+004.9781114
GO:0031334positive regulation of protein complex assembly3.13e-021.00e+004.9781214
GO:0009651response to salt stress3.13e-021.00e+004.9781214
GO:0019371cyclooxygenase pathway3.13e-021.00e+004.9781114
GO:0048568embryonic organ development3.13e-021.00e+004.9781114
GO:0007219Notch signaling pathway3.25e-021.00e+002.81924125
GO:0006349regulation of gene expression by genetic imprinting3.35e-021.00e+004.8781115
GO:0033280response to vitamin D3.35e-021.00e+004.8781115
GO:0046961proton-transporting ATPase activity, rotational mechanism3.35e-021.00e+004.8781315
GO:0045987positive regulation of smooth muscle contraction3.35e-021.00e+004.8781115
GO:0008654phospholipid biosynthetic process3.35e-021.00e+004.8781115
GO:0048025negative regulation of mRNA splicing, via spliceosome3.35e-021.00e+004.8781115
GO:0050998nitric-oxide synthase binding3.57e-021.00e+004.7851116
GO:0051968positive regulation of synaptic transmission, glutamatergic3.57e-021.00e+004.7851116
GO:0007520myoblast fusion3.57e-021.00e+004.7851116
GO:0051603proteolysis involved in cellular protein catabolic process3.57e-021.00e+004.7851216
GO:0046034ATP metabolic process3.57e-021.00e+004.7851116
GO:0000790nuclear chromatin3.65e-021.00e+002.73027133
GO:0018108peptidyl-tyrosine phosphorylation3.65e-021.00e+002.73023133
GO:0007411axon guidance3.75e-021.00e+002.01739327
GO:0005525GTP binding3.78e-021.00e+002.012311328
GO:0042149cellular response to glucose starvation3.79e-021.00e+004.6981117
GO:0035255ionotropic glutamate receptor binding3.79e-021.00e+004.6981117
GO:0003746translation elongation factor activity3.79e-021.00e+004.6981317
GO:0075733intracellular transport of virus3.79e-021.00e+004.6981217
GO:0006309apoptotic DNA fragmentation3.79e-021.00e+004.6981117
GO:0070372regulation of ERK1 and ERK2 cascade3.79e-021.00e+004.6981117
GO:0008283cell proliferation3.87e-021.00e+001.999312331
GO:0070064proline-rich region binding4.00e-021.00e+004.6151218
GO:0031122cytoplasmic microtubule organization4.00e-021.00e+004.6151218
GO:0035861site of double-strand break4.00e-021.00e+004.6151118
GO:0010800positive regulation of peptidyl-threonine phosphorylation4.00e-021.00e+004.6151118
GO:0005657replication fork4.00e-021.00e+004.6151318
GO:0042346positive regulation of NF-kappaB import into nucleus4.00e-021.00e+004.6151218
GO:0005246calcium channel regulator activity4.00e-021.00e+004.6151118
GO:0051721protein phosphatase 2A binding4.00e-021.00e+004.6151118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process4.22e-021.00e+004.5371119
GO:0035035histone acetyltransferase binding4.22e-021.00e+004.5371119
GO:0071158positive regulation of cell cycle arrest4.22e-021.00e+004.5371119
GO:0046697decidualization4.22e-021.00e+004.5371119
GO:0007088regulation of mitosis4.22e-021.00e+004.5371119
GO:0010165response to X-ray4.22e-021.00e+004.5371219
GO:0035145exon-exon junction complex4.22e-021.00e+004.5371219
GO:0048863stem cell differentiation4.22e-021.00e+004.5371119
GO:0004601peroxidase activity4.22e-021.00e+004.5371119
GO:0061024membrane organization4.32e-021.00e+002.59525146
GO:0015078hydrogen ion transmembrane transporter activity4.44e-021.00e+004.4631320
GO:0051090regulation of sequence-specific DNA binding transcription factor activity4.44e-021.00e+004.4631120
GO:0002931response to ischemia4.44e-021.00e+004.4631120
GO:0008045motor neuron axon guidance4.44e-021.00e+004.4631120
GO:0005680anaphase-promoting complex4.44e-021.00e+004.4631420
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator4.44e-021.00e+004.4631120
GO:0006298mismatch repair4.44e-021.00e+004.4631620
GO:0007369gastrulation4.66e-021.00e+004.3931121
GO:0001954positive regulation of cell-matrix adhesion4.66e-021.00e+004.3931121
GO:0008156negative regulation of DNA replication4.66e-021.00e+004.3931121
GO:0030010establishment of cell polarity4.66e-021.00e+004.3931221
GO:0005669transcription factor TFIID complex4.87e-021.00e+004.3261122
GO:0014065phosphatidylinositol 3-kinase signaling4.87e-021.00e+004.3261122
GO:0090200positive regulation of release of cytochrome c from mitochondria4.87e-021.00e+004.3261122
GO:0017080sodium channel regulator activity4.87e-021.00e+004.3261122
GO:0006297nucleotide-excision repair, DNA gap filling4.87e-021.00e+004.3261522
GO:0006656phosphatidylcholine biosynthetic process4.87e-021.00e+004.3261322
GO:0032201telomere maintenance via semi-conservative replication4.87e-021.00e+004.3261722
GO:0030863cortical cytoskeleton4.87e-021.00e+004.3261122
GO:0036464cytoplasmic ribonucleoprotein granule4.87e-021.00e+004.3261422
GO:0006974cellular response to DNA damage stimulus4.97e-021.00e+002.48128158
GO:0045087innate immune response4.97e-021.00e+001.518420616
GO:0008543fibroblast growth factor receptor signaling pathway5.03e-021.00e+002.47224159
GO:0031593polyubiquitin binding5.09e-021.00e+004.2611123
GO:0031463Cul3-RING ubiquitin ligase complex5.09e-021.00e+004.2611223
GO:0043236laminin binding5.09e-021.00e+004.2611123
GO:0045907positive regulation of vasoconstriction5.09e-021.00e+004.2611123
GO:0010575positive regulation vascular endothelial growth factor production5.09e-021.00e+004.2611123
GO:0006513protein monoubiquitination5.09e-021.00e+004.2611123
GO:0048709oligodendrocyte differentiation5.09e-021.00e+004.2611123
GO:0043044ATP-dependent chromatin remodeling5.09e-021.00e+004.2611423
GO:0043005neuron projection5.14e-021.00e+002.45424161
GO:0008135translation factor activity, nucleic acid binding5.30e-021.00e+004.2001424
GO:0010634positive regulation of epithelial cell migration5.30e-021.00e+004.2001124
GO:0001836release of cytochrome c from mitochondria5.30e-021.00e+004.2001224
GO:0045765regulation of angiogenesis5.30e-021.00e+004.2001124
GO:0048147negative regulation of fibroblast proliferation5.30e-021.00e+004.2001124
GO:0000794condensed nuclear chromosome5.30e-021.00e+004.2001224
GO:0005977glycogen metabolic process5.30e-021.00e+004.2001124
GO:2000379positive regulation of reactive oxygen species metabolic process5.30e-021.00e+004.2001124
GO:0006611protein export from nucleus5.52e-021.00e+004.1411425
GO:0032781positive regulation of ATPase activity5.52e-021.00e+004.1411125
GO:0001816cytokine production5.52e-021.00e+004.1411125
GO:0008536Ran GTPase binding5.52e-021.00e+004.1411225
GO:0030016myofibril5.52e-021.00e+004.1411125
GO:0071479cellular response to ionizing radiation5.52e-021.00e+004.1411125
GO:0007569cell aging5.52e-021.00e+004.1411225
GO:0019838growth factor binding5.52e-021.00e+004.1411125
GO:0006397mRNA processing5.61e-021.00e+002.38423169
GO:0070979protein K11-linked ubiquitination5.73e-021.00e+004.0851326
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia5.73e-021.00e+004.0851226
GO:0015459potassium channel regulator activity5.73e-021.00e+004.0851126
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway5.73e-021.00e+004.0851326
GO:0000722telomere maintenance via recombination5.73e-021.00e+004.0851726
GO:0007616long-term memory5.95e-021.00e+004.0301127
GO:0019843rRNA binding5.95e-021.00e+004.0301327
GO:0007422peripheral nervous system development5.95e-021.00e+004.0301127
GO:0016607nuclear speck5.96e-021.00e+002.33424175
GO:0015991ATP hydrolysis coupled proton transport6.16e-021.00e+003.9781428
GO:0043022ribosome binding6.16e-021.00e+003.9781328
GO:0031492nucleosomal DNA binding6.16e-021.00e+003.9781428
GO:0019894kinesin binding6.16e-021.00e+003.9781128
GO:0034612response to tumor necrosis factor6.16e-021.00e+003.9781228
GO:0000118histone deacetylase complex6.16e-021.00e+003.9781128
GO:0000381regulation of alternative mRNA splicing, via spliceosome6.38e-021.00e+003.9271229
GO:0006099tricarboxylic acid cycle6.38e-021.00e+003.9271329
GO:0019005SCF ubiquitin ligase complex6.38e-021.00e+003.9271129
GO:0043198dendritic shaft6.38e-021.00e+003.9271129
GO:0010332response to gamma radiation6.38e-021.00e+003.9271229
GO:0004712protein serine/threonine/tyrosine kinase activity6.38e-021.00e+003.9271129
GO:0030669clathrin-coated endocytic vesicle membrane6.38e-021.00e+003.9271129
GO:0006606protein import into nucleus6.59e-021.00e+003.8781130
GO:0023014signal transduction by phosphorylation6.59e-021.00e+003.8781130
GO:0051262protein tetramerization6.59e-021.00e+003.8781330
GO:0021549cerebellum development6.59e-021.00e+003.8781130
GO:0004714transmembrane receptor protein tyrosine kinase activity6.59e-021.00e+003.8781230
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator6.59e-021.00e+003.8781230
GO:0050873brown fat cell differentiation6.80e-021.00e+003.8311231
GO:0006271DNA strand elongation involved in DNA replication6.80e-021.00e+003.8311931
GO:0017048Rho GTPase binding6.80e-021.00e+003.8311131
GO:0031623receptor internalization6.80e-021.00e+003.8311131
GO:0046677response to antibiotic6.80e-021.00e+003.8311231
GO:0016604nuclear body6.80e-021.00e+003.8311231
GO:0007094mitotic spindle assembly checkpoint6.80e-021.00e+003.8311531
GO:0007173epidermal growth factor receptor signaling pathway6.95e-021.00e+002.20824191
GO:0050661NADP binding7.01e-021.00e+003.7851132
GO:0002250adaptive immune response7.01e-021.00e+003.7851132
GO:1903507negative regulation of nucleic acid-templated transcription7.01e-021.00e+003.7851232
GO:0007528neuromuscular junction development7.01e-021.00e+003.7851132
GO:0015992proton transport7.01e-021.00e+003.7851332
GO:0032091negative regulation of protein binding7.22e-021.00e+003.7411133
GO:2001244positive regulation of intrinsic apoptotic signaling pathway7.22e-021.00e+003.7411133
GO:0030282bone mineralization7.22e-021.00e+003.7411133
GO:0030971receptor tyrosine kinase binding7.22e-021.00e+003.7411233
GO:0001837epithelial to mesenchymal transition7.22e-021.00e+003.7411133
GO:0033077T cell differentiation in thymus7.22e-021.00e+003.7411233
GO:0030017sarcomere7.43e-021.00e+003.6981134
GO:0004175endopeptidase activity7.43e-021.00e+003.6981234
GO:0043407negative regulation of MAP kinase activity7.43e-021.00e+003.6981134
GO:0051701interaction with host7.43e-021.00e+003.6981434
GO:0005876spindle microtubule7.43e-021.00e+003.6981334
GO:0097192extrinsic apoptotic signaling pathway in absence of ligand7.64e-021.00e+003.6561235
GO:0045429positive regulation of nitric oxide biosynthetic process7.64e-021.00e+003.6561335
GO:0032588trans-Golgi network membrane7.85e-021.00e+003.6151136
GO:0034332adherens junction organization7.85e-021.00e+003.6151136
GO:0051402neuron apoptotic process7.85e-021.00e+003.6151236
GO:0032855positive regulation of Rac GTPase activity7.85e-021.00e+003.6151136
GO:0007566embryo implantation7.85e-021.00e+003.6151136
GO:0030838positive regulation of actin filament polymerization7.85e-021.00e+003.6151236
GO:0042552myelination7.85e-021.00e+003.6151136
GO:0001895retina homeostasis7.85e-021.00e+003.6151136
GO:0016301kinase activity8.06e-021.00e+003.5761337
GO:0051084'de novo' posttranslational protein folding8.06e-021.00e+003.5761437
GO:00515394 iron, 4 sulfur cluster binding8.06e-021.00e+003.5761337
GO:0001701in utero embryonic development8.18e-021.00e+002.07126210
GO:0001756somitogenesis8.27e-021.00e+003.5371138
GO:0070527platelet aggregation8.27e-021.00e+003.5371238
GO:0090382phagosome maturation8.27e-021.00e+003.5371538
GO:0051496positive regulation of stress fiber assembly8.48e-021.00e+003.5001239
GO:0032092positive regulation of protein binding8.48e-021.00e+003.5001339
GO:0021766hippocampus development8.48e-021.00e+003.5001439
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription8.69e-021.00e+003.4631240
GO:0000781chromosome, telomeric region8.69e-021.00e+003.4631240
GO:0007596blood coagulation8.72e-021.00e+001.512314464
GO:0006468protein phosphorylation8.85e-021.00e+001.503310467
GO:0045786negative regulation of cell cycle8.90e-021.00e+003.4271141
GO:0045785positive regulation of cell adhesion8.90e-021.00e+003.4271541
GO:0005546phosphatidylinositol-4,5-bisphosphate binding8.90e-021.00e+003.4271241
GO:0071363cellular response to growth factor stimulus9.10e-021.00e+003.3931242
GO:0006418tRNA aminoacylation for protein translation9.10e-021.00e+003.3931542
GO:0005902microvillus9.10e-021.00e+003.3931242
GO:0043647inositol phosphate metabolic process9.10e-021.00e+003.3931142
GO:0004715non-membrane spanning protein tyrosine kinase activity9.10e-021.00e+003.3931142
GO:0042110T cell activation9.31e-021.00e+003.3591343
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process9.52e-021.00e+003.3261344
GO:0034613cellular protein localization9.52e-021.00e+003.3261144
GO:0006892post-Golgi vesicle-mediated transport9.52e-021.00e+003.3261244
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding9.52e-021.00e+003.3261244
GO:0050434positive regulation of viral transcription9.52e-021.00e+003.3261544
GO:0007067mitotic nuclear division9.62e-021.00e+001.933213231
GO:0008380RNA splicing9.69e-021.00e+001.927213232
GO:0015030Cajal body9.72e-021.00e+003.2931245
GO:0005759mitochondrial matrix9.76e-021.00e+001.921212233
GO:0030136clathrin-coated vesicle9.93e-021.00e+003.2611146
GO:0043525positive regulation of neuron apoptotic process9.93e-021.00e+003.2611246
GO:0006283transcription-coupled nucleotide-excision repair9.93e-021.00e+003.2611846
GO:0021762substantia nigra development9.93e-021.00e+003.2611146
GO:0007612learning9.93e-021.00e+003.2611146
GO:0043406positive regulation of MAP kinase activity1.01e-011.00e+003.2301247
GO:0006921cellular component disassembly involved in execution phase of apoptosis1.01e-011.00e+003.2301547
GO:0005507copper ion binding1.03e-011.00e+003.2001248
GO:0006950response to stress1.03e-011.00e+003.2001348
GO:0022625cytosolic large ribosomal subunit1.05e-011.00e+003.1701549
GO:0048661positive regulation of smooth muscle cell proliferation1.05e-011.00e+003.1701249
GO:0019369arachidonic acid metabolic process1.05e-011.00e+003.1701249
GO:0003743translation initiation factor activity1.05e-011.00e+003.1701449
GO:0019233sensory perception of pain1.05e-011.00e+003.1701149
GO:0035690cellular response to drug1.07e-011.00e+003.1411250
GO:0006091generation of precursor metabolites and energy1.09e-011.00e+003.1131351
GO:0045444fat cell differentiation1.09e-011.00e+003.1131151
GO:0045732positive regulation of protein catabolic process1.09e-011.00e+003.1131451
GO:0030334regulation of cell migration1.11e-011.00e+003.0851252
GO:0003725double-stranded RNA binding1.16e-011.00e+003.0301654
GO:0007623circadian rhythm1.16e-011.00e+003.0301154
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1.16e-011.00e+003.0301554
GO:0050679positive regulation of epithelial cell proliferation1.16e-011.00e+003.0301154
GO:0097193intrinsic apoptotic signaling pathway1.18e-011.00e+003.0041455
GO:0000226microtubule cytoskeleton organization1.18e-011.00e+003.0041355
GO:0006814sodium ion transport1.18e-011.00e+003.0041155
GO:0007613memory1.20e-011.00e+002.9781256
GO:0008104protein localization1.20e-011.00e+002.9781356
GO:0006968cellular defense response1.20e-011.00e+002.9781156
GO:0008565protein transporter activity1.22e-011.00e+002.9521257
GO:0006879cellular iron ion homeostasis1.22e-011.00e+002.9521557
GO:0000724double-strand break repair via homologous recombination1.22e-011.00e+002.9521657
GO:0012505endomembrane system1.22e-011.00e+002.9521257
GO:0007202activation of phospholipase C activity1.24e-011.00e+002.9271158
GO:0002244hematopoietic progenitor cell differentiation1.24e-011.00e+002.9271158
GO:0051087chaperone binding1.26e-011.00e+002.9021659
GO:0045216cell-cell junction organization1.26e-011.00e+002.9021259
GO:0000723telomere maintenance1.26e-011.00e+002.9021859
GO:0005643nuclear pore1.26e-011.00e+002.9021459
GO:0005840ribosome1.26e-011.00e+002.9021259
GO:0048011neurotrophin TRK receptor signaling pathway1.27e-011.00e+001.69226273
GO:0008013beta-catenin binding1.28e-011.00e+002.8781460
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway1.30e-011.00e+002.8541261
GO:0033138positive regulation of peptidyl-serine phosphorylation1.30e-011.00e+002.8541361
GO:0051384response to glucocorticoid1.31e-011.00e+002.8311262
GO:0005901caveola1.33e-011.00e+002.8081363
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway1.35e-011.00e+002.7851164
GO:0042493response to drug1.38e-011.00e+001.615211288
GO:0001558regulation of cell growth1.39e-011.00e+002.7411466
GO:0042060wound healing1.43e-011.00e+002.6981168
GO:0018105peptidyl-serine phosphorylation1.45e-011.00e+002.6761169
GO:0050790regulation of catalytic activity1.45e-011.00e+002.6761369
GO:0030307positive regulation of cell growth1.47e-011.00e+002.6561270
GO:0035264multicellular organism growth1.47e-011.00e+002.6561170
GO:0034329cell junction assembly1.49e-011.00e+002.6351171
GO:0032355response to estradiol1.53e-011.00e+002.5951573
GO:0000785chromatin1.53e-011.00e+002.5951573
GO:0002020protease binding1.55e-011.00e+002.5761474
GO:0005856cytoskeleton1.56e-011.00e+001.50428311
GO:0004674protein serine/threonine kinase activity1.57e-011.00e+001.50026312
GO:0001843neural tube closure1.57e-011.00e+002.5561275
GO:0007265Ras protein signal transduction1.57e-011.00e+002.5561375
GO:0060070canonical Wnt signaling pathway1.57e-011.00e+002.5561375
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation1.57e-011.00e+002.5561175
GO:0046474glycerophospholipid biosynthetic process1.59e-011.00e+002.5371376
GO:0035556intracellular signal transduction1.61e-011.00e+001.47726317
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.61e-011.00e+002.5181577
GO:0008584male gonad development1.61e-011.00e+002.5181277
GO:0071013catalytic step 2 spliceosome1.65e-011.00e+002.4811779
GO:0030154cell differentiation1.68e-011.00e+001.44125325
GO:0001726ruffle1.70e-011.00e+002.4271482
GO:0002576platelet degranulation1.70e-011.00e+002.4271482
GO:0004713protein tyrosine kinase activity1.70e-011.00e+002.4271282
GO:0005681spliceosomal complex1.72e-011.00e+002.4101383
GO:0043197dendritic spine1.72e-011.00e+002.4101283
GO:0006898receptor-mediated endocytosis1.78e-011.00e+002.3591286
GO:0050852T cell receptor signaling pathway1.81e-011.00e+002.3261288
GO:0090090negative regulation of canonical Wnt signaling pathway1.81e-011.00e+002.3261388
GO:0032321positive regulation of Rho GTPase activity1.81e-011.00e+002.3261188
GO:0009887organ morphogenesis1.83e-011.00e+002.3091289
GO:0006979response to oxidative stress1.85e-011.00e+002.2931490
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II1.89e-011.00e+002.2611492
GO:0016310phosphorylation1.94e-011.00e+002.2151295
GO:0006364rRNA processing1.96e-011.00e+002.2001596
GO:0030426growth cone1.98e-011.00e+002.1851397
GO:0005178integrin binding1.98e-011.00e+002.1851297
GO:0008285negative regulation of cell proliferation2.02e-011.00e+001.265211367
GO:0004888transmembrane signaling receptor activity2.09e-011.00e+002.09811103
GO:0043235receptor complex2.11e-011.00e+002.08512104
GO:0005739mitochondrion2.11e-011.00e+000.7544241046
GO:0014069postsynaptic density2.14e-011.00e+002.05711106
GO:0001934positive regulation of protein phosphorylation2.18e-011.00e+002.03015108
GO:0031410cytoplasmic vesicle2.22e-011.00e+002.00412110
GO:0042127regulation of cell proliferation2.23e-011.00e+001.99114111
GO:0020037heme binding2.23e-011.00e+001.99112111
GO:0006461protein complex assembly2.23e-011.00e+001.99116111
GO:0015630microtubule cytoskeleton2.25e-011.00e+001.97815112
GO:0030308negative regulation of cell growth2.27e-011.00e+001.96516113
GO:0046982protein heterodimerization activity2.29e-011.00e+001.145211399
GO:0008289lipid binding2.32e-011.00e+001.92711116
GO:0005635nuclear envelope2.32e-011.00e+001.92716116
GO:0044237cellular metabolic process2.36e-011.00e+001.90213118
GO:0032496response to lipopolysaccharide2.43e-011.00e+001.85414122
GO:0006325chromatin organization2.44e-011.00e+001.84214123
GO:0051092positive regulation of NF-kappaB transcription factor activity2.48e-011.00e+001.81914125
GO:0006260DNA replication2.48e-011.00e+001.819112125
GO:0007050cell cycle arrest2.50e-011.00e+001.80817126
GO:0006511ubiquitin-dependent protein catabolic process2.51e-011.00e+001.79615127
GO:0005506iron ion binding2.51e-011.00e+001.79613127
GO:0030036actin cytoskeleton organization2.55e-011.00e+001.77415129
GO:0007179transforming growth factor beta receptor signaling pathway2.56e-011.00e+001.76313130
GO:0016477cell migration2.58e-011.00e+001.75216131
GO:0046983protein dimerization activity2.58e-011.00e+001.75213131
GO:0009615response to virus2.60e-011.00e+001.74116132
GO:0031982vesicle2.63e-011.00e+001.719110134
GO:0006644phospholipid metabolic process2.68e-011.00e+001.68715137
GO:0000086G2/M transition of mitotic cell cycle2.68e-011.00e+001.68717137
GO:0045202synapse2.73e-011.00e+001.65613140
GO:0007507heart development2.75e-011.00e+001.64515141
GO:0005911cell-cell junction2.77e-011.00e+001.63513142
GO:0045944positive regulation of transcription from RNA polymerase II promoter2.78e-011.00e+000.706319811
GO:0016887ATPase activity2.80e-011.00e+001.61517144
GO:0008286insulin receptor signaling pathway2.80e-011.00e+001.61516144
GO:0010628positive regulation of gene expression2.88e-011.00e+001.56614149
GO:0006457protein folding2.88e-011.00e+001.56618149
GO:0007166cell surface receptor signaling pathway2.88e-011.00e+001.56611149
GO:0016323basolateral plasma membrane2.88e-011.00e+001.56613149
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription2.91e-011.00e+001.54712151
GO:0055114oxidation-reduction process2.98e-011.00e+000.875211481
GO:0010008endosome membrane3.01e-011.00e+001.49016157
GO:0046777protein autophosphorylation3.03e-011.00e+001.48113158
GO:0005198structural molecule activity3.04e-011.00e+001.47214159
GO:0042802identical protein binding3.06e-011.00e+000.845218491
GO:0045121membrane raft3.07e-011.00e+001.45418161
GO:0008022protein C-terminus binding3.07e-011.00e+001.45414161
GO:0000398mRNA splicing, via spliceosome3.14e-011.00e+001.419112165
GO:0034220ion transmembrane transport3.17e-011.00e+001.40112167
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding3.18e-011.00e+001.39315168
GO:0044212transcription regulatory region DNA binding3.23e-011.00e+001.36716171
GO:0030424axon3.25e-011.00e+001.35913172
GO:0006886intracellular protein transport3.26e-011.00e+001.35014173
GO:0055085transmembrane transport3.26e-011.00e+000.77928514
GO:0031965nuclear membrane3.31e-011.00e+001.32614176
GO:0048471perinuclear region of cytoplasm3.33e-011.00e+000.754212523
GO:0003714transcription corepressor activity3.35e-011.00e+001.30117179
GO:0019904protein domain specific binding3.38e-011.00e+001.28516181
GO:0032403protein complex binding3.44e-011.00e+001.25417185
GO:0001525angiogenesis3.67e-011.00e+001.14114200
GO:0030168platelet activation3.74e-011.00e+001.10619205
GO:0005765lysosomal membrane3.92e-011.00e+001.01715218
GO:0016324apical plasma membrane4.01e-011.00e+000.97812224
GO:0019221cytokine-mediated signaling pathway4.09e-011.00e+000.93913230
GO:0005789endoplasmic reticulum membrane4.26e-011.00e+000.472210636
GO:0008134transcription factor binding4.30e-011.00e+000.84218246
GO:0008270zinc ion binding4.39e-011.00e+000.3113121067
GO:0043025neuronal cell body4.41e-011.00e+000.79614254
GO:0004842ubiquitin-protein transferase activity4.43e-011.00e+000.78514256
GO:0005102receptor binding4.58e-011.00e+000.71915268
GO:0005975carbohydrate metabolic process4.66e-011.00e+000.68715274
GO:0006357regulation of transcription from RNA polymerase II promoter4.67e-011.00e+000.68216275
GO:0003779actin binding4.67e-011.00e+000.68217275
GO:0007283spermatogenesis4.68e-011.00e+000.67616276
GO:0006954inflammatory response4.84e-011.00e+000.61016289
GO:0016567protein ubiquitination4.96e-011.00e+000.56115299
GO:0006200ATP catabolic process5.00e-011.00e+000.542114303
GO:0043231intracellular membrane-bounded organelle5.33e-011.00e+000.41018332
GO:0003682chromatin binding5.35e-011.00e+000.401112334
GO:0007275multicellular organismal development5.46e-011.00e+000.35915344
GO:0007155cell adhesion5.86e-011.00e+000.20018384
GO:0006508proteolysis6.10e-011.00e+000.10619410
GO:0045892negative regulation of transcription, DNA-templated6.23e-011.00e+000.057114424
GO:0005886plasma membrane6.40e-011.00e+00-0.0996382834
GO:0007165signal transduction6.43e-011.00e+00-0.107217950
GO:0046872metal ion binding6.57e-011.00e+00-0.1473241465
GO:0045893positive regulation of transcription, DNA-templated6.74e-011.00e+00-0.143117487
GO:0000122negative regulation of transcription from RNA polymerase II promoter7.44e-011.00e+00-0.417112589
GO:0005783endoplasmic reticulum7.56e-011.00e+00-0.46819610
GO:0042803protein homodimerization activity7.60e-011.00e+00-0.484111617
GO:0003700sequence-specific DNA binding transcription factor activity8.24e-011.00e+00-0.762111748
GO:0006351transcription, DNA-templated8.87e-011.00e+00-0.8452251585
GO:0005615extracellular space9.06e-011.00e+00-1.1951171010
GO:0006355regulation of transcription, DNA-templated9.25e-011.00e+00-1.3241171104
GO:0003677DNA binding9.59e-011.00e+00-1.6151261351
GO:0016021integral component of membrane9.83e-011.00e+00-1.4932152483