int-snw-5216

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 1.002 3.25e-18 5.25e-04 1.26e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-5216 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
CDC16 8881 250.9501.02080Yes-
EIF2S2 8894 271.0751.13881Yes-
RBX1 9978 971.1851.151139Yes-
[ PFN1 ] 5216 1-0.1431.00278--
PSMD3 5709 570.9861.106146Yes-
CLTC 1213 350.8841.138247Yes-
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
RPSA 3921 1561.3271.151152Yes-

Interactions (19)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
CLTC 1213 PFN1 5216 pp -- int.I2D: BioGrid_Mouse
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 PFN1 5216 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, BioGrid_Mouse, HPRD, MINT_Mouse, BCI, IntAct;
int.HPRD: in vitro;
int.DIP: MI:0407(direct interaction)
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
CLTC 1213 EIF2S2 8894 pp -- int.I2D: YeastLow
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CDC16 8881 pp -- int.I2D: YeastLow
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast

Related GO terms (213)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.23e-091.77e-056.53152265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.80e-092.59e-056.42452270
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.39e-093.44e-056.34452274
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process3.33e-094.81e-056.24952379
GO:0005829cytosol4.14e-085.97e-042.405111322496
GO:0006521regulation of cellular amino acid metabolic process6.20e-088.94e-046.58741750
GO:0000082G1/S transition of mitotic cell cycle8.22e-081.19e-035.334532149
GO:0000502proteasome complex1.14e-071.64e-036.37341758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.70e-072.45e-036.23141964
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent2.74e-073.95e-036.06142072
GO:0000278mitotic cell cycle3.07e-074.44e-034.205648391
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I3.23e-074.67e-036.00242075
GO:0005654nucleoplasm3.69e-075.32e-033.1528761082
GO:0016071mRNA metabolic process6.13e-078.84e-034.752531223
GO:0002474antigen processing and presentation of peptide antigen via MHC class I7.38e-071.06e-025.70842192
GO:0016070RNA metabolic process1.02e-061.46e-024.605532247
GO:0000209protein polyubiquitination1.87e-062.70e-025.373420116
GO:0016032viral process1.91e-062.76e-023.755655534
GO:0042981regulation of apoptotic process5.21e-067.52e-025.002424150
GO:0010467gene expression7.08e-061.02e-013.430659669
GO:0034641cellular nitrogen compound metabolic process8.77e-061.26e-014.813420171
GO:0005838proteasome regulatory particle4.17e-056.01e-017.6462712
GO:0022624proteasome accessory complex8.57e-051.00e+007.1442817
GO:0005839proteasome core complex9.64e-051.00e+007.0612818
GO:0004298threonine-type endopeptidase activity1.08e-041.00e+006.9832819
GO:0070062extracellular vesicular exosome1.53e-041.00e+002.00281042400
GO:0043066negative regulation of apoptotic process3.02e-041.00e+003.503431424
GO:0005515protein binding4.97e-041.00e+001.134111846024
GO:0006915apoptotic process8.39e-041.00e+003.115433555
GO:0016020membrane1.23e-031.00e+002.1016901681
GO:0051054positive regulation of DNA metabolic process1.66e-031.00e+009.231112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.66e-031.00e+009.231112
GO:0002176male germ cell proliferation1.66e-031.00e+009.231112
GO:0005055laminin receptor activity1.66e-031.00e+009.231112
GO:0006407rRNA export from nucleus1.66e-031.00e+009.231112
GO:0005850eukaryotic translation initiation factor 2 complex2.49e-031.00e+008.646113
GO:1900126negative regulation of hyaluronan biosynthetic process2.49e-031.00e+008.646123
GO:0071439clathrin complex2.49e-031.00e+008.646123
GO:0005925focal adhesion3.01e-031.00e+003.300319366
GO:0000774adenyl-nucleotide exchange factor activity3.32e-031.00e+008.231114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.32e-031.00e+008.231114
GO:003068690S preribosome3.32e-031.00e+008.231114
GO:0032051clathrin light chain binding3.32e-031.00e+008.231114
GO:0031467Cul7-RING ubiquitin ligase complex3.32e-031.00e+008.231114
GO:0019788NEDD8 ligase activity3.32e-031.00e+008.231114
GO:0032232negative regulation of actin filament bundle assembly3.32e-031.00e+008.231114
GO:1903077negative regulation of protein localization to plasma membrane3.32e-031.00e+008.231114
GO:0072562blood microparticle3.68e-031.00e+004.43723111
GO:0005819spindle3.75e-031.00e+004.42427112
GO:1900029positive regulation of ruffle assembly4.15e-031.00e+007.909115
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.15e-031.00e+007.909135
GO:0031461cullin-RING ubiquitin ligase complex4.15e-031.00e+007.909115
GO:0043248proteasome assembly4.15e-031.00e+007.909115
GO:0030891VCB complex4.15e-031.00e+007.909125
GO:0000730DNA recombinase assembly4.15e-031.00e+007.909115
GO:2000001regulation of DNA damage checkpoint4.15e-031.00e+007.909115
GO:0030130clathrin coat of trans-Golgi network vesicle4.98e-031.00e+007.646136
GO:0030957Tat protein binding4.98e-031.00e+007.646136
GO:0030118clathrin coat4.98e-031.00e+007.646126
GO:0031466Cul5-RING ubiquitin ligase complex4.98e-031.00e+007.646116
GO:0006413translational initiation5.09e-031.00e+004.198217131
GO:0030132clathrin coat of coated pit5.81e-031.00e+007.424127
GO:0000028ribosomal small subunit assembly5.81e-031.00e+007.424117
GO:0031462Cul2-RING ubiquitin ligase complex5.81e-031.00e+007.424127
GO:0061024membrane organization6.20e-031.00e+004.05127145
GO:0044267cellular protein metabolic process6.22e-031.00e+002.927329474
GO:0019773proteasome core complex, alpha-subunit complex6.64e-031.00e+007.231148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.64e-031.00e+007.231128
GO:0070688MLL5-L complex6.64e-031.00e+007.231118
GO:0045116protein neddylation6.64e-031.00e+007.231128
GO:0030837negative regulation of actin filament polymerization7.47e-031.00e+007.061119
GO:0051497negative regulation of stress fiber assembly7.47e-031.00e+007.061119
GO:0010569regulation of double-strand break repair via homologous recombination8.29e-031.00e+006.9091110
GO:0044822poly(A) RNA binding8.79e-031.00e+002.1874491056
GO:0031571mitotic G1 DNA damage checkpoint9.12e-031.00e+006.7721411
GO:0031625ubiquitin protein ligase binding9.22e-031.00e+003.755214178
GO:0005662DNA replication factor A complex1.08e-021.00e+006.5311113
GO:0030234enzyme regulator activity1.08e-021.00e+006.5311313
GO:0035267NuA4 histone acetyltransferase complex1.16e-021.00e+006.4241414
GO:0050998nitric-oxide synthase binding1.32e-021.00e+006.2311116
GO:0042176regulation of protein catabolic process1.32e-021.00e+006.2311316
GO:0044281small molecule metabolic process1.42e-021.00e+001.9894581211
GO:0007067mitotic nuclear division1.47e-021.00e+003.405214227
GO:0007088regulation of mitosis1.49e-021.00e+006.0611118
GO:0070064proline-rich region binding1.49e-021.00e+006.0611218
GO:0035861site of double-strand break1.49e-021.00e+006.0611118
GO:0006412translation1.50e-021.00e+003.386220230
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.57e-021.00e+005.9831119
GO:0048863stem cell differentiation1.57e-021.00e+005.9831119
GO:0005680anaphase-promoting complex1.65e-021.00e+005.9091420
GO:0006298mismatch repair1.65e-021.00e+005.9091320
GO:0032201telomere maintenance via semi-conservative replication1.73e-021.00e+005.8391521
GO:0000718nucleotide-excision repair, DNA damage removal1.73e-021.00e+005.8391421
GO:0006297nucleotide-excision repair, DNA gap filling1.82e-021.00e+005.7721322
GO:0030863cortical cytoskeleton1.82e-021.00e+005.7721122
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721422
GO:0043044ATP-dependent chromatin remodeling1.90e-021.00e+005.7081423
GO:0005844polysome1.90e-021.00e+005.7081423
GO:0031463Cul3-RING ubiquitin ligase complex1.90e-021.00e+005.7081323
GO:0043236laminin binding1.90e-021.00e+005.7081123
GO:0006513protein monoubiquitination1.90e-021.00e+005.7081123
GO:0006281DNA repair1.91e-021.00e+003.203218261
GO:0008135translation factor activity, nucleic acid binding1.98e-021.00e+005.6461724
GO:0032781positive regulation of ATPase activity1.98e-021.00e+005.6461124
GO:0010634positive regulation of epithelial cell migration1.98e-021.00e+005.6461124
GO:0000722telomere maintenance via recombination2.06e-021.00e+005.5871525
GO:0070979protein K11-linked ubiquitination2.14e-021.00e+005.5311626
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.14e-021.00e+005.5311326
GO:0043022ribosome binding2.22e-021.00e+005.4761327
GO:0031492nucleosomal DNA binding2.22e-021.00e+005.4761427
GO:0030669clathrin-coated endocytic vesicle membrane2.31e-021.00e+005.4241428
GO:0019894kinesin binding2.31e-021.00e+005.4241128
GO:0005856cytoskeleton2.34e-021.00e+003.046212291
GO:0019005SCF ubiquitin ligase complex2.39e-021.00e+005.3731129
GO:0043234protein complex2.40e-021.00e+003.027218295
GO:0033572transferrin transport2.47e-021.00e+005.3241530
GO:0006271DNA strand elongation involved in DNA replication2.47e-021.00e+005.3241730
GO:0017048Rho GTPase binding2.55e-021.00e+005.2771131
GO:0031623receptor internalization2.55e-021.00e+005.2771231
GO:0007094mitotic spindle assembly checkpoint2.55e-021.00e+005.2771431
GO:0019901protein kinase binding2.75e-021.00e+002.923221317
GO:0032588trans-Golgi network membrane2.79e-021.00e+005.1441234
GO:0001895retina homeostasis2.79e-021.00e+005.1441134
GO:0030838positive regulation of actin filament polymerization2.79e-021.00e+005.1441234
GO:0005876spindle microtubule2.79e-021.00e+005.1441234
GO:0005813centrosome2.89e-021.00e+002.882214326
GO:0034332adherens junction organization2.96e-021.00e+005.0611136
GO:0051084'de novo' posttranslational protein folding3.04e-021.00e+005.0221437
GO:0006284base-excision repair3.04e-021.00e+005.0221337
GO:0051496positive regulation of stress fiber assembly3.12e-021.00e+004.9831238
GO:0070527platelet aggregation3.12e-021.00e+004.9831238
GO:0003723RNA binding3.16e-021.00e+002.813220342
GO:0022627cytosolic small ribosomal subunit3.20e-021.00e+004.9461439
GO:0000781chromosome, telomeric region3.20e-021.00e+004.9461339
GO:0005546phosphatidylinositol-4,5-bisphosphate binding3.20e-021.00e+004.9461239
GO:0030136clathrin-coated vesicle3.44e-021.00e+004.8391442
GO:0071363cellular response to growth factor stimulus3.44e-021.00e+004.8391142
GO:0006892post-Golgi vesicle-mediated transport3.52e-021.00e+004.8051343
GO:0021762substantia nigra development3.60e-021.00e+004.7721244
GO:0050434positive regulation of viral transcription3.60e-021.00e+004.7721644
GO:0006283transcription-coupled nucleotide-excision repair3.76e-021.00e+004.7081746
GO:0005730nucleolus3.91e-021.00e+001.5514691641
GO:0003743translation initiation factor activity4.00e-021.00e+004.6161849
GO:0003684damaged DNA binding4.00e-021.00e+004.6161749
GO:0003725double-stranded RNA binding4.24e-021.00e+004.5311552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.32e-021.00e+004.5031553
GO:0045216cell-cell junction organization4.40e-021.00e+004.4761254
GO:0000724double-strand break repair via homologous recombination4.48e-021.00e+004.4501355
GO:0000723telomere maintenance4.56e-021.00e+004.4241656
GO:0019903protein phosphatase binding5.04e-021.00e+004.2771462
GO:0006302double-strand break repair5.04e-021.00e+004.2771462
GO:0005634nucleus5.06e-021.00e+000.88471364559
GO:0007596blood coagulation5.32e-021.00e+002.401218455
GO:0006289nucleotide-excision repair5.52e-021.00e+004.14411168
GO:0034329cell junction assembly5.52e-021.00e+004.1441168
GO:0003697single-stranded DNA binding5.52e-021.00e+004.1441568
GO:0001843neural tube closure5.99e-021.00e+004.0221474
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.99e-021.00e+004.0221674
GO:0008584male gonad development6.07e-021.00e+004.0021375
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.07e-021.00e+004.0021275
GO:0019083viral transcription6.54e-021.00e+003.89111081
GO:0002576platelet degranulation6.62e-021.00e+003.8741482
GO:0006898receptor-mediated endocytosis6.77e-021.00e+003.8391384
GO:0047485protein N-terminus binding6.93e-021.00e+003.8051586
GO:0006415translational termination7.01e-021.00e+003.78811087
GO:0016605PML body7.08e-021.00e+003.7721388
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II7.24e-021.00e+003.7391790
GO:0042470melanosome7.32e-021.00e+003.7231991
GO:0006928cellular component movement7.32e-021.00e+003.7231791
GO:0005200structural constituent of cytoskeleton7.32e-021.00e+003.7231891
GO:0001649osteoblast differentiation7.39e-021.00e+003.7081692
GO:0071456cellular response to hypoxia7.39e-021.00e+003.7081692
GO:0006414translational elongation7.47e-021.00e+003.69211393
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.32e-021.00e+003.531110104
GO:0014069postsynaptic density8.40e-021.00e+003.51713105
GO:0015630microtubule cytoskeleton8.78e-021.00e+003.45014110
GO:0030529ribonucleoprotein complex8.93e-021.00e+003.42418112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay9.09e-021.00e+003.398111114
GO:0019058viral life cycle9.16e-021.00e+003.386113115
GO:0006325chromatin organization9.39e-021.00e+003.34815118
GO:0007219Notch signaling pathway9.54e-021.00e+003.32415120
GO:0006260DNA replication9.62e-021.00e+003.31219121
GO:0030036actin cytoskeleton organization9.77e-021.00e+003.28915123
GO:0006511ubiquitin-dependent protein catabolic process1.00e-011.00e+003.25415126
GO:0000790nuclear chromatin1.02e-011.00e+003.22019129
GO:0031982vesicle1.04e-011.00e+003.19819131
GO:0003735structural constituent of ribosome1.08e-011.00e+003.133110137
GO:0045202synapse1.08e-011.00e+003.14413136
GO:0006457protein folding1.13e-011.00e+003.07117143
GO:0005198structural molecule activity1.18e-011.00e+003.00215150
GO:0043005neuron projection1.23e-011.00e+002.93716157
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.29e-011.00e+002.86517165
GO:0030424axon1.30e-011.00e+002.85614166
GO:0006886intracellular protein transport1.33e-011.00e+002.81315171
GO:0032403protein complex binding1.42e-011.00e+002.715110183
GO:0001701in utero embryonic development1.55e-011.00e+002.58018201
GO:0030168platelet activation1.58e-011.00e+002.552110205
GO:0004842ubiquitin-protein transferase activity1.93e-011.00e+002.23716255
GO:0005102receptor binding1.96e-011.00e+002.20916260
GO:0003779actin binding2.00e-011.00e+002.176112266
GO:0019899enzyme binding2.08e-011.00e+002.117112277
GO:0016567protein ubiquitination2.20e-011.00e+002.02715295
GO:0007411axon guidance2.35e-011.00e+001.914113319
GO:0008283cell proliferation2.41e-011.00e+001.874114328
GO:0007155cell adhesion2.67e-011.00e+001.70416369
GO:0005737cytoplasm3.86e-011.00e+000.35241103767
GO:0045087innate immune response3.97e-011.00e+001.012124596
GO:0045944positive regulation of transcription from RNA polymerase II promoter4.91e-011.00e+000.607119789
GO:0005615extracellular space5.61e-011.00e+000.329117957
GO:0008270zinc ion binding5.77e-011.00e+000.270112997
GO:0005886plasma membrane6.61e-011.00e+00-0.1032452582
GO:0005524ATP binding6.78e-011.00e+00-0.1111601298
GO:0046872metal ion binding6.80e-011.00e+00-0.1211251307