Related GO terms (2371)

Accession number Name Occurrences in all snw genes Occurrences in all int/reg genes
GO:0009897external side of plasma membrane3177
GO:0000381regulation of alternative mRNA splicing, via spliceosome126
GO:0014013regulation of gliogenesis11
GO:0044237cellular metabolic process5117
GO:0005769early endosome2152
GO:0001558regulation of cell growth261
GO:0009263deoxyribonucleotide biosynthetic process13
GO:0008092cytoskeletal protein binding147
GO:0035529NADH pyrophosphatase activity13
GO:0007286spermatid development141
GO:0004003ATP-dependent DNA helicase activity227
GO:0030101natural killer cell activation116
GO:0008094DNA-dependent ATPase activity234
GO:0046718viral entry into host cell218
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen19
GO:0005663DNA replication factor C complex16
GO:0097202activation of cysteine-type endopeptidase activity18
GO:0051054positive regulation of DNA metabolic process12
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity111
GO:0030168platelet activation10205
GO:0003725double-stranded RNA binding552
GO:0043508negative regulation of JUN kinase activity113
GO:0033209tumor necrosis factor-mediated signaling pathway228
GO:0006272leading strand elongation22
GO:0051092positive regulation of NF-kappaB transcription factor activity4124
GO:0042921glucocorticoid receptor signaling pathway17
GO:0043204perikaryon155
GO:0045171intercellular bridge230
GO:0016601Rac protein signal transduction117
GO:0060071Wnt signaling pathway, planar cell polarity pathway210
GO:0045252oxoglutarate dehydrogenase complex22
GO:0015746citrate transport12
GO:0032781positive regulation of ATPase activity124
GO:2001239regulation of extrinsic apoptotic signaling pathway in absence of ligand111
GO:0030316osteoclast differentiation122
GO:1903416response to glycoside13
GO:1990138neuron projection extension15
GO:0008234cysteine-type peptidase activity337
GO:0001102RNA polymerase II activating transcription factor binding236
GO:0050840extracellular matrix binding118
GO:0030705cytoskeleton-dependent intracellular transport114
GO:0045892negative regulation of transcription, DNA-templated15413
GO:0071229cellular response to acid chemical15
GO:0008017microtubule binding6147
GO:0035789metanephric mesenchymal cell migration11
GO:0042100B cell proliferation121
GO:0003231cardiac ventricle development13
GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity13
GO:0030902hindbrain development115
GO:0004305ethanolamine kinase activity14
GO:0051084'de novo' posttranslational protein folding437
GO:0032959inositol trisphosphate biosynthetic process12
GO:0033276transcription factor TFTC complex114
GO:007188914-3-3 protein binding118
GO:0010977negative regulation of neuron projection development228
GO:0008283cell proliferation14328
GO:0097021lymphocyte migration into lymphoid organs12
GO:0031122cytoplasmic microtubule organization118
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage549
GO:0051491positive regulation of filopodium assembly121
GO:0030336negative regulation of cell migration178
GO:0005672transcription factor TFIIA complex15
GO:0035102PRC1 complex112
GO:0034686integrin alphav-beta8 complex12
GO:0021702cerebellar Purkinje cell differentiation112
GO:0008284positive regulation of cell proliferation8382
GO:0034314Arp2/3 complex-mediated actin nucleation111
GO:0030857negative regulation of epithelial cell differentiation18
GO:0043627response to estrogen256
GO:0034134toll-like receptor 2 signaling pathway273
GO:0090005negative regulation of establishment of protein localization to plasma membrane17
GO:0004818glutamate-tRNA ligase activity12
GO:0006703estrogen biosynthetic process16
GO:0006612protein targeting to membrane118
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay11114
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules191
GO:0045944positive regulation of transcription from RNA polymerase II promoter19789
GO:0051402neuron apoptotic process236
GO:0006970response to osmotic stress113
GO:0031011Ino80 complex314
GO:0055114oxidation-reduction process12420
GO:0032703negative regulation of interleukin-2 production110
GO:0034162toll-like receptor 9 signaling pathway272
GO:0003712transcription cofactor activity144
GO:0007229integrin-mediated signaling pathway278
GO:0007623circadian rhythm153
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity13
GO:0045111intermediate filament cytoskeleton147
GO:0006407rRNA export from nucleus12
GO:0005882intermediate filament261
GO:0046688response to copper ion113
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity11
GO:0031702type 1 angiotensin receptor binding19
GO:0043966histone H3 acetylation145
GO:0034602oxoglutarate dehydrogenase (NAD+) activity11
GO:0000052citrulline metabolic process14
GO:0000210NAD+ diphosphatase activity11
GO:0035035histone acetyltransferase binding119
GO:0005847mRNA cleavage and polyadenylation specificity factor complex18
GO:0070127tRNA aminoacylation for mitochondrial protein translation11
GO:0048714positive regulation of oligodendrocyte differentiation211
GO:0032967positive regulation of collagen biosynthetic process121
GO:0031982vesicle9131
GO:0003697single-stranded DNA binding568
GO:0050882voluntary musculoskeletal movement13
GO:0097193intrinsic apoptotic signaling pathway655
GO:0034116positive regulation of heterotypic cell-cell adhesion17
GO:0032060bleb assembly18
GO:0005125cytokine activity1138
GO:0030154cell differentiation5301
GO:0000398mRNA splicing, via spliceosome8164
GO:0043066negative regulation of apoptotic process31424
GO:0004004ATP-dependent RNA helicase activity218
GO:0034405response to fluid shear stress18
GO:0042824MHC class I peptide loading complex12
GO:0010888negative regulation of lipid storage27
GO:0031415NatA complex15
GO:0043008ATP-dependent protein binding17
GO:0051117ATPase binding140
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2192
GO:0045907positive regulation of vasoconstriction122
GO:0010634positive regulation of epithelial cell migration124
GO:0071813lipoprotein particle binding14
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening125
GO:0030225macrophage differentiation115
GO:1902167positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator12
GO:0001836release of cytochrome c from mitochondria324
GO:0046325negative regulation of glucose import17
GO:0034765regulation of ion transmembrane transport198
GO:2000466negative regulation of glycogen (starch) synthase activity13
GO:0031428box C/D snoRNP complex14
GO:0048680positive regulation of axon regeneration13
GO:0000228nuclear chromosome133
GO:0042594response to starvation131
GO:0019904protein domain specific binding6179
GO:0032480negative regulation of type I interferon production132
GO:0006836neurotransmitter transport116
GO:0019899enzyme binding12277
GO:0001649osteoblast differentiation692
GO:0050561glutamate-tRNA(Gln) ligase activity11
GO:0006360transcription from RNA polymerase I promoter530
GO:0043243positive regulation of protein complex disassembly13
GO:0048012hepatocyte growth factor receptor signaling pathway16
GO:0048487beta-tubulin binding230
GO:0006068ethanol catabolic process14
GO:0030041actin filament polymerization321
GO:0005654nucleoplasm761082
GO:0006458'de novo' protein folding13
GO:0047498calcium-dependent phospholipase A2 activity17
GO:0007507heart development7139
GO:0031902late endosome membrane177
GO:0048742regulation of skeletal muscle fiber development15
GO:0061048negative regulation of branching involved in lung morphogenesis11
GO:0043531ADP binding128
GO:0030055cell-substrate junction11
GO:0043029T cell homeostasis121
GO:0018105peptidyl-serine phosphorylation569
GO:0032387negative regulation of intracellular transport14
GO:0007220Notch receptor processing122
GO:0033365protein localization to organelle116
GO:0043141ATP-dependent 5'-3' DNA helicase activity14
GO:0000776kinetochore463
GO:1990077primosome complex12
GO:0030032lamellipodium assembly229
GO:0000922spindle pole287
GO:0014070response to organic cyclic compound443
GO:0045986negative regulation of smooth muscle contraction15
GO:0006269DNA replication, synthesis of RNA primer25
GO:0007088regulation of mitosis118
GO:1990430extracellular matrix protein binding12
GO:0060136embryonic process involved in female pregnancy17
GO:0046329negative regulation of JNK cascade123
GO:0030183B cell differentiation254
GO:0019789SUMO ligase activity111
GO:0071230cellular response to amino acid stimulus342
GO:0071013catalytic step 2 spliceosome478
GO:0045765regulation of angiogenesis124
GO:0051301cell division581
GO:0021695cerebellar cortex development26
GO:0030529ribonucleoprotein complex8112
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process2379
GO:0016514SWI/SNF complex315
GO:0050794regulation of cellular process12
GO:0007346regulation of mitotic cell cycle129
GO:0006260DNA replication9121
GO:0007512adult heart development116
GO:0043274phospholipase binding116
GO:0035019somatic stem cell maintenance140
GO:0001890placenta development131
GO:0003690double-stranded DNA binding186
GO:0043014alpha-tubulin binding123
GO:0030170pyridoxal phosphate binding149
GO:0055007cardiac muscle cell differentiation118
GO:0016255attachment of GPI anchor to protein17
GO:0048471perinuclear region of cytoplasm13502
GO:0005916fascia adherens113
GO:0004022alcohol dehydrogenase (NAD) activity15
GO:0006626protein targeting to mitochondrion144
GO:0071455cellular response to hyperoxia17
GO:0007275multicellular organismal development5316
GO:0050748negative regulation of lipoprotein metabolic process12
GO:0070542response to fatty acid114
GO:0090343positive regulation of cell aging12
GO:0019226transmission of nerve impulse114
GO:0007283spermatogenesis8262
GO:0003730mRNA 3'-UTR binding226
GO:0035909aorta morphogenesis112
GO:0004758serine C-palmitoyltransferase activity13
GO:0016021integral component of membrane271982
GO:0050770regulation of axonogenesis126
GO:0019843rRNA binding327
GO:0043022ribosome binding327
GO:0018279protein N-linked glycosylation via asparagine281
GO:0030891VCB complex25
GO:0030017sarcomere134
GO:0004090carbonyl reductase (NADPH) activity14
GO:0016788hydrolase activity, acting on ester bonds111
GO:0051972regulation of telomerase activity11
GO:0031264death-inducing signaling complex16
GO:0032469endoplasmic reticulum calcium ion homeostasis111
GO:0004992platelet activating factor receptor activity22
GO:0002360T cell lineage commitment23
GO:0032403protein complex binding10183
GO:0000132establishment of mitotic spindle orientation116
GO:0086009membrane repolarization18
GO:0032587ruffle membrane370
GO:0032092positive regulation of protein binding338
GO:0022008neurogenesis124
GO:0033512L-lysine catabolic process to acetyl-CoA via saccharopine13
GO:0046933proton-transporting ATP synthase activity, rotational mechanism19
GO:0006605protein targeting235
GO:0006432phenylalanyl-tRNA aminoacylation13
GO:0007213G-protein coupled acetylcholine receptor signaling pathway111
GO:0048147negative regulation of fibroblast proliferation122
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I2075
GO:0071339MLL1 complex327
GO:0034599cellular response to oxidative stress233
GO:0035639purine ribonucleoside triphosphate binding11
GO:1903507negative regulation of nucleic acid-templated transcription232
GO:0031226intrinsic component of plasma membrane113
GO:0033326cerebrospinal fluid secretion14
GO:0006891intra-Golgi vesicle-mediated transport117
GO:0005153interleukin-8 receptor binding12
GO:0030953astral microtubule organization13
GO:0016197endosomal transport157
GO:0006686sphingomyelin biosynthetic process14
GO:0010887negative regulation of cholesterol storage16
GO:0002224toll-like receptor signaling pathway3109
GO:0034235GPI anchor binding17
GO:0005080protein kinase C binding143
GO:0006273lagging strand elongation14
GO:0007265Ras protein signal transduction275
GO:0034146toll-like receptor 5 signaling pathway265
GO:0045859regulation of protein kinase activity126
GO:0008217regulation of blood pressure457
GO:0006069ethanol oxidation110
GO:0071222cellular response to lipopolysaccharide181
GO:0006526arginine biosynthetic process13
GO:0043405regulation of MAP kinase activity15
GO:0051480cytosolic calcium ion homeostasis118
GO:0006783heme biosynthetic process120
GO:0050482arachidonic acid secretion113
GO:0071930negative regulation of transcription involved in G1/S transition of mitotic cell cycle13
GO:0043374CD8-positive, alpha-beta T cell differentiation14
GO:0050681androgen receptor binding338
GO:0071377cellular response to glucagon stimulus235
GO:2000510positive regulation of dendritic cell chemotaxis14
GO:0001702gastrulation with mouth forming second221
GO:0051289protein homotetramerization151
GO:0050786RAGE receptor binding111
GO:0042277peptide binding335
GO:0030141secretory granule262
GO:0045719negative regulation of glycogen biosynthetic process18
GO:0000724double-strand break repair via homologous recombination355
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2274
GO:0046007negative regulation of activated T cell proliferation16
GO:0043403skeletal muscle tissue regeneration211
GO:0006475internal protein amino acid acetylation17
GO:0015485cholesterol binding127
GO:0032508DNA duplex unwinding341
GO:0033211adiponectin-activated signaling pathway16
GO:0051497negative regulation of stress fiber assembly19
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2270
GO:0034142toll-like receptor 4 signaling pathway396
GO:0045453bone resorption219
GO:0009411response to UV144
GO:0042060wound healing264
GO:0019894kinesin binding128
GO:0005200structural constituent of cytoskeleton891
GO:2000474regulation of opioid receptor signaling pathway12
GO:0006446regulation of translational initiation436
GO:0070374positive regulation of ERK1 and ERK2 cascade2106
GO:0006426glycyl-tRNA aminoacylation11
GO:0021766hippocampus development438
GO:0030199collagen fibril organization137
GO:1990086lens fiber cell apoptotic process14
GO:0030728ovulation17
GO:0006289nucleotide-excision repair1168
GO:0021762substantia nigra development244
GO:0008152metabolic process3258
GO:0004832valine-tRNA ligase activity12
GO:0006184GTP catabolic process12214
GO:0002181cytoplasmic translation16
GO:0016607nuclear speck3172
GO:0042054histone methyltransferase activity18
GO:0003924GTPase activity12197
GO:1901990regulation of mitotic cell cycle phase transition14
GO:0009306protein secretion120
GO:0033327Leydig cell differentiation112
GO:0005743mitochondrial inner membrane8277
GO:0051099positive regulation of binding17
GO:0008150biological_process3389
GO:0004723calcium-dependent protein serine/threonine phosphatase activity12
GO:0007077mitotic nuclear envelope disassembly136
GO:0000278mitotic cell cycle48391
GO:0006878cellular copper ion homeostasis112
GO:0031464Cul4A-RING E3 ubiquitin ligase complex28
GO:0010499proteasomal ubiquitin-independent protein catabolic process24
GO:1903038negative regulation of leukocyte cell-cell adhesion11
GO:0032886regulation of microtubule-based process312
GO:0030282bone mineralization129
GO:0007267cell-cell signaling1219
GO:0097527necroptotic signaling pathway16
GO:0008033tRNA processing134
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2265
GO:0090188negative regulation of pancreatic juice secretion13
GO:0016071mRNA metabolic process31223
GO:0030855epithelial cell differentiation461
GO:0097136Bcl-2 family protein complex13
GO:0034220ion transmembrane transport4149
GO:0046983protein dimerization activity2118
GO:0097110scaffold protein binding334
GO:0001570vasculogenesis156
GO:0007158neuron cell-cell adhesion113
GO:0061384heart trabecula morphogenesis13
GO:0001105RNA polymerase II transcription coactivator activity124
GO:0070885negative regulation of calcineurin-NFAT signaling cascade14
GO:0034613cellular protein localization144
GO:0032797SMN complex111
GO:0010575positive regulation vascular endothelial growth factor production121
GO:0006950response to stress246
GO:0050919negative chemotaxis117
GO:0006414translational elongation1393
GO:0035793positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway13
GO:0050766positive regulation of phagocytosis123
GO:0007179transforming growth factor beta receptor signaling pathway4128
GO:0005667transcription factor complex4175
GO:0005829cytosol1322496
GO:0048532anatomical structure arrangement11
GO:0030971receptor tyrosine kinase binding233
GO:0010718positive regulation of epithelial to mesenchymal transition125
GO:0042542response to hydrogen peroxide139
GO:0001676long-chain fatty acid metabolic process114
GO:0000775chromosome, centromeric region250
GO:0008340determination of adult lifespan111
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis674
GO:0040007growth225
GO:0050821protein stabilization288
GO:0032689negative regulation of interferon-gamma production124
GO:0003707steroid hormone receptor activity145
GO:0006385transcription elongation from RNA polymerase III promoter318
GO:0000781chromosome, telomeric region339
GO:0000339RNA cap binding18
GO:0070436Grb2-EGFR complex12
GO:0046321positive regulation of fatty acid oxidation13
GO:0000188inactivation of MAPK activity127
GO:0008654phospholipid biosynthetic process113
GO:0048172regulation of short-term neuronal synaptic plasticity19
GO:0038031non-canonical Wnt signaling pathway via JNK cascade15
GO:0031996thioesterase binding114
GO:0005778peroxisomal membrane147
GO:0060333interferon-gamma-mediated signaling pathway262
GO:0014075response to amine19
GO:0048096chromatin-mediated maintenance of transcription17
GO:0055117regulation of cardiac muscle contraction115
GO:0045793positive regulation of cell size29
GO:0005789endoplasmic reticulum membrane16570
GO:0006106fumarate metabolic process11
GO:0006310DNA recombination265
GO:0043200response to amino acid123
GO:0005131growth hormone receptor binding15
GO:0060342photoreceptor inner segment membrane12
GO:0090280positive regulation of calcium ion import113
GO:0001944vasculature development124
GO:0004745retinol dehydrogenase activity17
GO:0045294alpha-catenin binding18
GO:0004103choline kinase activity12
GO:0005575cellular_component1279
GO:0033596TSC1-TSC2 complex13
GO:0007497posterior midgut development12
GO:0006513protein monoubiquitination123
GO:0016469proton-transporting two-sector ATPase complex15
GO:0016573histone acetylation123
GO:0001667ameboidal-type cell migration16
GO:0004842ubiquitin-protein transferase activity6255
GO:2000811negative regulation of anoikis116
GO:0003779actin binding12266
GO:0016757transferase activity, transferring glycosyl groups16
GO:0010507negative regulation of autophagy118
GO:0060338regulation of type I interferon-mediated signaling pathway121
GO:2000377regulation of reactive oxygen species metabolic process114
GO:0051222positive regulation of protein transport14
GO:0005096GTPase activator activity1102
GO:0000812Swr1 complex38
GO:0004677DNA-dependent protein kinase activity14
GO:0061001regulation of dendritic spine morphogenesis211
GO:0031490chromatin DNA binding338
GO:0043968histone H2A acetylation312
GO:0002162dystroglycan binding17
GO:0005869dynactin complex18
GO:0042555MCM complex29
GO:0005912adherens junction235
GO:0035264multicellular organism growth167
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors15
GO:0010592positive regulation of lamellipodium assembly111
GO:0031094platelet dense tubular network13
GO:0035335peptidyl-tyrosine dephosphorylation192
GO:0006355regulation of transcription, DNA-templated18997
GO:0042624ATPase activity, uncoupled11
GO:0004177aminopeptidase activity123
GO:0007004telomere maintenance via telomerase111
GO:0038091positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway13
GO:0031648protein destabilization121
GO:0015992proton transport329
GO:0051219phosphoprotein binding232
GO:0007018microtubule-based movement157
GO:0009409response to cold226
GO:0036376sodium ion export from cell16
GO:0005813centrosome14326
GO:0010467gene expression59669
GO:0071636positive regulation of transforming growth factor beta production15
GO:0034166toll-like receptor 10 signaling pathway265
GO:0007049cell cycle2174
GO:0042981regulation of apoptotic process24150
GO:0071682endocytic vesicle lumen116
GO:0006646phosphatidylethanolamine biosynthetic process212
GO:0051015actin filament binding292
GO:1990259histone-glutamine methyltransferase activity11
GO:0007601visual perception1157
GO:0046854phosphatidylinositol phosphorylation128
GO:0000185activation of MAPKKK activity29
GO:0061154endothelial tube morphogenesis15
GO:0070062extracellular vesicular exosome1042400
GO:0030036actin cytoskeleton organization5123
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway325
GO:0030148sphingolipid biosynthetic process226
GO:0003824catalytic activity150
GO:0014069postsynaptic density3105
GO:0050921positive regulation of chemotaxis213
GO:0004197cysteine-type endopeptidase activity350
GO:0008104protein localization356
GO:0008559xenobiotic-transporting ATPase activity13
GO:0090314positive regulation of protein targeting to membrane116
GO:0005662DNA replication factor A complex113
GO:0031941filamentous actin122
GO:0042995cell projection660
GO:0006657CDP-choline pathway27
GO:0006895Golgi to endosome transport111
GO:0005506iron ion binding4105
GO:0071398cellular response to fatty acid112
GO:0031461cullin-RING ubiquitin ligase complex15
GO:0036152phosphatidylethanolamine acyl-chain remodeling114
GO:0048812neuron projection morphogenesis131
GO:0043044ATP-dependent chromatin remodeling423
GO:0005739mitochondrion28998
GO:0050431transforming growth factor beta binding115
GO:0044027hypermethylation of CpG island13
GO:0000902cell morphogenesis249
GO:0042552myelination135
GO:0043548phosphatidylinositol 3-kinase binding221
GO:0021549cerebellum development129
GO:2000785regulation of autophagic vacuole assembly17
GO:0035339SPOTS complex12
GO:0031265CD95 death-inducing signaling complex16
GO:0050434positive regulation of viral transcription644
GO:0048499synaptic vesicle membrane organization12
GO:0050790regulation of catalytic activity269
GO:0006437tyrosyl-tRNA aminoacylation11
GO:0009887organ morphogenesis286
GO:0097194execution phase of apoptosis119
GO:0072661protein targeting to plasma membrane119
GO:0008601protein phosphatase type 2A regulator activity220
GO:0060318definitive erythrocyte differentiation14
GO:0051260protein homooligomerization2145
GO:0045672positive regulation of osteoclast differentiation118
GO:0046696lipopolysaccharide receptor complex15
GO:2001295malonyl-CoA biosynthetic process12
GO:0046898response to cycloheximide12
GO:1903078positive regulation of protein localization to plasma membrane13
GO:0004714transmembrane receptor protein tyrosine kinase activity230
GO:2000738positive regulation of stem cell differentiation15
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway436
GO:0036150phosphatidylserine acyl-chain remodeling19
GO:0070372regulation of ERK1 and ERK2 cascade117
GO:0010043response to zinc ion124
GO:0021591ventricular system development213
GO:0005680anaphase-promoting complex420
GO:0071564npBAF complex311
GO:0018107peptidyl-threonine phosphorylation437
GO:0032764negative regulation of mast cell cytokine production12
GO:0032880regulation of protein localization137
GO:0006461protein complex assembly6111
GO:0030957Tat protein binding36
GO:0071456cellular response to hypoxia692
GO:0016578histone deubiquitination111
GO:0000248C-5 sterol desaturase activity12
GO:0005218intracellular ligand-gated calcium channel activity13
GO:0031072heat shock protein binding133
GO:0005956protein kinase CK2 complex11
GO:0042470melanosome991
GO:0090103cochlea morphogenesis220
GO:0097342ripoptosome17
GO:0016192vesicle-mediated transport1117
GO:0005977glycogen metabolic process124
GO:0071476cellular hypotonic response16
GO:0045071negative regulation of viral genome replication134
GO:0017145stem cell division17
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway110
GO:0045624positive regulation of T-helper cell differentiation11
GO:0050870positive regulation of T cell activation117
GO:0001841neural tube formation110
GO:0052689carboxylic ester hydrolase activity110
GO:0019898extrinsic component of membrane142
GO:0019838growth factor binding125
GO:0043025neuronal cell body9245
GO:0005887integral component of plasma membrane6888
GO:0005178integrin binding296
GO:0033619membrane protein proteolysis15
GO:0050806positive regulation of synaptic transmission112
GO:0005764lysosome2172
GO:0000790nuclear chromatin9129
GO:0003887DNA-directed DNA polymerase activity328
GO:0060322head development19
GO:0031430M band117
GO:0031497chromatin assembly17
GO:0055003cardiac myofibril assembly111
GO:0050851antigen receptor-mediated signaling pathway15
GO:0030324lung development172
GO:0000354cis assembly of pre-catalytic spliceosome12
GO:0050805negative regulation of synaptic transmission14
GO:0007406negative regulation of neuroblast proliferation16
GO:0005164tumor necrosis factor receptor binding230
GO:0071318cellular response to ATP110
GO:0009651response to salt stress214
GO:0030424axon4166
GO:0016070RNA metabolic process32247
GO:0006397mRNA processing2160
GO:0004712protein serine/threonine/tyrosine kinase activity429
GO:0032319regulation of Rho GTPase activity29
GO:0006298mismatch repair320
GO:0030234enzyme regulator activity313
GO:0004070aspartate carbamoyltransferase activity11
GO:0043507positive regulation of JUN kinase activity228
GO:0044212transcription regulatory region DNA binding6168
GO:0001894tissue homeostasis117
GO:0007568aging3117
GO:0000930gamma-tubulin complex17
GO:0050966detection of mechanical stimulus involved in sensory perception of pain17
GO:0048260positive regulation of receptor-mediated endocytosis213
GO:0006303double-strand break repair via nonhomologous end joining218
GO:0019371cyclooxygenase pathway112
GO:0016323basolateral plasma membrane4135
GO:0030863cortical cytoskeleton122
GO:0001865NK T cell differentiation12
GO:0031000response to caffeine29
GO:0061146Peyer's patch morphogenesis13
GO:0019233sensory perception of pain148
GO:0000118histone deacetylase complex128
GO:0086004regulation of cardiac muscle cell contraction110
GO:0006622protein targeting to lysosome110
GO:0043393regulation of protein binding120
GO:0030687preribosome, large subunit precursor13
GO:0032154cleavage furrow238
GO:0005525GTP binding12310
GO:0042113B cell activation225
GO:0031394positive regulation of prostaglandin biosynthetic process15
GO:0010664negative regulation of striated muscle cell apoptotic process14
GO:0032735positive regulation of interleukin-12 production125
GO:0021819layer formation in cerebral cortex111
GO:0030976thiamine pyrophosphate binding15
GO:0030659cytoplasmic vesicle membrane2101
GO:0036477somatodendritic compartment12
GO:0050775positive regulation of dendrite morphogenesis115
GO:0060414aorta smooth muscle tissue morphogenesis12
GO:0031589cell-substrate adhesion116
GO:0005578proteinaceous extracellular matrix1160
GO:0009725response to hormone135
GO:0030224monocyte differentiation116
GO:0022027interkinetic nuclear migration19
GO:0048008platelet-derived growth factor receptor signaling pathway227
GO:0045502dynein binding211
GO:0042593glucose homeostasis187
GO:0048407platelet-derived growth factor binding111
GO:0044255cellular lipid metabolic process6133
GO:0030315T-tubule137
GO:0030276clathrin binding220
GO:0051894positive regulation of focal adhesion assembly118
GO:1900029positive regulation of ruffle assembly15
GO:0071549cellular response to dexamethasone stimulus120
GO:0005518collagen binding154
GO:0044770cell cycle phase transition15
GO:0045667regulation of osteoblast differentiation19
GO:0045945positive regulation of transcription from RNA polymerase III promoter111
GO:0010008endosome membrane7151
GO:0008565protein transporter activity556
GO:0051087chaperone binding659
GO:0002842positive regulation of T cell mediated immune response to tumor cell11
GO:0004955prostaglandin receptor activity11
GO:0048870cell motility115
GO:0042256mature ribosome assembly15
GO:0051571positive regulation of histone H3-K4 methylation111
GO:0051291protein heterooligomerization256
GO:0045931positive regulation of mitotic cell cycle126
GO:0032050clathrin heavy chain binding14
GO:0004674protein serine/threonine kinase activity12308
GO:0045239tricarboxylic acid cycle enzyme complex11
GO:0048169regulation of long-term neuronal synaptic plasticity121
GO:0002009morphogenesis of an epithelium112
GO:0035064methylated histone binding146
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway271
GO:0002328pro-B cell differentiation15
GO:0001516prostaglandin biosynthetic process112
GO:0009249protein lipoylation15
GO:0072075metanephric mesenchyme development18
GO:0004345glucose-6-phosphate dehydrogenase activity11
GO:0070294renal sodium ion absorption14
GO:0090271positive regulation of fibroblast growth factor production11
GO:0023014signal transduction by phosphorylation128
GO:0031588AMP-activated protein kinase complex19
GO:0001822kidney development278
GO:0004605phosphatidate cytidylyltransferase activity13
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process119
GO:0032496response to lipopolysaccharide4121
GO:0006368transcription elongation from RNA polymerase II promoter667
GO:0000307cyclin-dependent protein kinase holoenzyme complex18
GO:0030286dynein complex111
GO:0048839inner ear development237
GO:0070064proline-rich region binding218
GO:0035493SNARE complex assembly17
GO:0006531aspartate metabolic process16
GO:0032727positive regulation of interferon-alpha production111
GO:0005793endoplasmic reticulum-Golgi intermediate compartment156
GO:0010424DNA methylation on cytosine within a CG sequence13
GO:0001816cytokine production325
GO:0050661NADP binding227
GO:0000235astral microtubule11
GO:0014043negative regulation of neuron maturation12
GO:0006607NLS-bearing protein import into nucleus314
GO:0003774motor activity243
GO:0071306cellular response to vitamin E12
GO:0006024glycosaminoglycan biosynthetic process123
GO:0000701purine-specific mismatch base pair DNA N-glycosylase activity11
GO:0048666neuron development234
GO:0019005SCF ubiquitin ligase complex129
GO:0008026ATP-dependent helicase activity339
GO:0045216cell-cell junction organization254
GO:0035925mRNA 3'-UTR AU-rich region binding15
GO:0060072large conductance calcium-activated potassium channel activity11
GO:0009395phospholipid catabolic process111
GO:0043652engulfment of apoptotic cell12
GO:0051262protein tetramerization230
GO:0002551mast cell chemotaxis14
GO:0006665sphingolipid metabolic process360
GO:0007000nucleolus organization14
GO:0007628adult walking behavior128
GO:0031622positive regulation of fever generation25
GO:0030666endocytic vesicle membrane453
GO:0043235receptor complex299
GO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage113
GO:0016881acid-amino acid ligase activity237
GO:0048291isotype switching to IgG isotypes11
GO:0006740NADPH regeneration12
GO:0051607defense response to virus1126
GO:0006351transcription, DNA-templated311446
GO:0030118clathrin coat26
GO:0015991ATP hydrolysis coupled proton transport426
GO:0006693prostaglandin metabolic process19
GO:0030133transport vesicle143
GO:0042551neuron maturation110
GO:0005615extracellular space17957
GO:0060693regulation of branching involved in salivary gland morphogenesis13
GO:0075732viral penetration into host nucleus12
GO:0006112energy reserve metabolic process395
GO:0045715negative regulation of low-density lipoprotein particle receptor biosynthetic process13
GO:0007369gastrulation119
GO:0043032positive regulation of macrophage activation110
GO:0007174epidermal growth factor catabolic process11
GO:0001523retinoid metabolic process248
GO:0007202activation of phospholipase C activity355
GO:0008195phosphatidate phosphatase activity19
GO:0010669epithelial structure maintenance14
GO:0031528microvillus membrane115
GO:0015035protein disulfide oxidoreductase activity121
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription237
GO:0072262metanephric glomerular mesangial cell proliferation involved in metanephros development12
GO:0031295T cell costimulation265
GO:0007616long-term memory227
GO:0007611learning or memory234
GO:0008574plus-end-directed microtubule motor activity115
GO:0005839proteasome core complex818
GO:0097208alveolar lamellar body16
GO:0050727regulation of inflammatory response345
GO:0071158positive regulation of cell cycle arrest219
GO:0031519PcG protein complex425
GO:0006200ATP catabolic process15292
GO:2000573positive regulation of DNA biosynthetic process111
GO:1902255positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator12
GO:0032591dendritic spine membrane15
GO:0080008Cul4-RING E3 ubiquitin ligase complex114
GO:0030904retromer complex215
GO:0030335positive regulation of cell migration7127
GO:0034244negative regulation of transcription elongation from RNA polymerase II promoter110
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity19
GO:0006096glycolytic process438
GO:0001846opsonin binding12
GO:0007566embryo implantation135
GO:0005391sodium:potassium-exchanging ATPase activity18
GO:0050998nitric-oxide synthase binding116
GO:0002903negative regulation of B cell apoptotic process16
GO:0045716positive regulation of low-density lipoprotein particle receptor biosynthetic process14
GO:0060020Bergmann glial cell differentiation14
GO:0051154negative regulation of striated muscle cell differentiation13
GO:0005640nuclear outer membrane122
GO:1900126negative regulation of hyaluronan biosynthetic process23
GO:0046697decidualization118
GO:0060557positive regulation of vitamin D biosynthetic process12
GO:0048562embryonic organ morphogenesis15
GO:0050690regulation of defense response to virus by virus427
GO:0071418cellular response to amine stimulus12
GO:0046511sphinganine biosynthetic process12
GO:0046976histone methyltransferase activity (H3-K27 specific)14
GO:0010800positive regulation of peptidyl-threonine phosphorylation117
GO:0008536Ran GTPase binding125
GO:0055088lipid homeostasis118
GO:0006047UDP-N-acetylglucosamine metabolic process13
GO:0019773proteasome core complex, alpha-subunit complex48
GO:0002244hematopoietic progenitor cell differentiation154
GO:0038085vascular endothelial growth factor binding14
GO:0030296protein tyrosine kinase activator activity19
GO:0045605negative regulation of epidermal cell differentiation11
GO:0045893positive regulation of transcription, DNA-templated13478
GO:0010225response to UV-C19
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway261
GO:0042254ribosome biogenesis130
GO:0051798positive regulation of hair follicle development14
GO:0051272positive regulation of cellular component movement111
GO:0060291long-term synaptic potentiation129
GO:0007264small GTPase mediated signal transduction4279
GO:0052066entry of symbiont into host cell by promotion of host phagocytosis11
GO:0070307lens fiber cell development210
GO:0016188synaptic vesicle maturation18
GO:0033572transferrin transport530
GO:0071353cellular response to interleukin-4120
GO:0001701in utero embryonic development8201
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription159
GO:0061034olfactory bulb mitral cell layer development12
GO:0010571positive regulation of nuclear cell cycle DNA replication15
GO:0048484enteric nervous system development110
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II790
GO:0006427histidyl-tRNA aminoacylation12
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process163
GO:0043248proteasome assembly15
GO:0005903brush border123
GO:0005102receptor binding6260
GO:0030016myofibril125
GO:0071109superior temporal gyrus development12
GO:0050544arachidonic acid binding15
GO:0070141response to UV-A13
GO:0030890positive regulation of B cell proliferation135
GO:0044267cellular protein metabolic process29474
GO:0002674negative regulation of acute inflammatory response17
GO:2000601positive regulation of Arp2/3 complex-mediated actin nucleation16
GO:0005856cytoskeleton12291
GO:0000910cytokinesis251
GO:0043220Schmidt-Lanterman incisure110
GO:0007403glial cell fate determination13
GO:0004750ribulose-phosphate 3-epimerase activity11
GO:0006744ubiquinone biosynthetic process110
GO:0004386helicase activity252
GO:0016529sarcoplasmic reticulum130
GO:0051642centrosome localization112
GO:0001765membrane raft assembly13
GO:0030914STAGA complex113
GO:0002756MyD88-independent toll-like receptor signaling pathway378
GO:0043596nuclear replication fork17
GO:1900121negative regulation of receptor binding13
GO:0043406positive regulation of MAP kinase activity446
GO:0051059NF-kappaB binding225
GO:0097225sperm midpiece18
GO:0070266necroptotic process112
GO:0000387spliceosomal snRNP assembly127
GO:0003975UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity11
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)12
GO:0043491protein kinase B signaling232
GO:0032281alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex116
GO:0009051pentose-phosphate shunt, oxidative branch23
GO:0061077chaperone-mediated protein folding231
GO:0004839ubiquitin activating enzyme activity14
GO:0006422aspartyl-tRNA aminoacylation11
GO:0035458cellular response to interferon-beta111
GO:0034103regulation of tissue remodeling13
GO:0008080N-acetyltransferase activity18
GO:0004871signal transducer activity4208
GO:0035567non-canonical Wnt signaling pathway15
GO:0046456icosanoid biosynthetic process12
GO:2001243negative regulation of intrinsic apoptotic signaling pathway121
GO:0070491repressing transcription factor binding128
GO:0046134pyrimidine nucleoside biosynthetic process16
GO:0022607cellular component assembly11
GO:0001085RNA polymerase II transcription factor binding233
GO:0002250adaptive immune response128
GO:0006979response to oxidative stress387
GO:0070262peptidyl-serine dephosphorylation11
GO:0015966diadenosine tetraphosphate biosynthetic process12
GO:0044306neuron projection terminus19
GO:0044233ER-mitochondrion membrane contact site15
GO:0071479cellular response to ionizing radiation123
GO:0014067negative regulation of phosphatidylinositol 3-kinase signaling111
GO:0001056RNA polymerase III activity316
GO:0000400four-way junction DNA binding19
GO:0010468regulation of gene expression168
GO:0030216keratinocyte differentiation147
GO:0004815aspartate-tRNA ligase activity22
GO:0045727positive regulation of translation344
GO:0033088negative regulation of immature T cell proliferation in thymus14
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity592
GO:0005681spliceosomal complex483
GO:0033574response to testosterone222
GO:0030042actin filament depolymerization28
GO:0004175endopeptidase activity232
GO:0043231intracellular membrane-bounded organelle9318
GO:0019521D-gluconate metabolic process11
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay153
GO:0001530lipopolysaccharide binding313
GO:0060749mammary gland alveolus development215
GO:0035690cellular response to drug249
GO:0035666TRIF-dependent toll-like receptor signaling pathway376
GO:0001158enhancer sequence-specific DNA binding116
GO:0071535RING-like zinc finger domain binding13
GO:0033613activating transcription factor binding118
GO:0000159protein phosphatase type 2A complex220
GO:0004364glutathione transferase activity118
GO:0070145mitochondrial asparaginyl-tRNA aminoacylation11
GO:0043973histone H3-K4 acetylation11
GO:0045600positive regulation of fat cell differentiation132
GO:0046902regulation of mitochondrial membrane permeability210
GO:0070577lysine-acetylated histone binding117
GO:0001891phagocytic cup213
GO:0045987positive regulation of smooth muscle contraction115
GO:0005220inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity13
GO:0035025positive regulation of Rho protein signal transduction110
GO:0071897DNA biosynthetic process228
GO:0003777microtubule motor activity158
GO:0050918positive chemotaxis130
GO:0051403stress-activated MAPK cascade254
GO:0019082viral protein processing112
GO:0004843ubiquitin-specific protease activity164
GO:0032755positive regulation of interleukin-6 production236
GO:0048745smooth muscle tissue development111
GO:0031225anchored component of membrane178
GO:0045335phagocytic vesicle233
GO:0008305integrin complex123
GO:0050699WW domain binding121
GO:0006357regulation of transcription from RNA polymerase II promoter8264
GO:0031514motile cilium140
GO:0015629actin cytoskeleton3177
GO:0005819spindle7112
GO:0016311dephosphorylation385
GO:0005634nucleus1364559
GO:0015459potassium channel regulator activity126
GO:0071236cellular response to antibiotic112
GO:0006417regulation of translation162
GO:0042346positive regulation of NF-kappaB import into nucleus218
GO:0060762regulation of branching involved in mammary gland duct morphogenesis16
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling4145
GO:0010614negative regulation of cardiac muscle hypertrophy16
GO:0002368B cell cytokine production11
GO:0048633positive regulation of skeletal muscle tissue growth12
GO:0010971positive regulation of G2/M transition of mitotic cell cycle211
GO:0031088platelet dense granule membrane15
GO:0006672ceramide metabolic process113
GO:0031674I band118
GO:0003735structural constituent of ribosome10137
GO:0004496mevalonate kinase activity11
GO:0008610lipid biosynthetic process19
GO:0005765lysosomal membrane5203
GO:0035267NuA4 histone acetyltransferase complex414
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling111
GO:0019985translesion synthesis211
GO:0006418tRNA aminoacylation for protein translation942
GO:0000774adenyl-nucleotide exchange factor activity14
GO:0033138positive regulation of peptidyl-serine phosphorylation259
GO:0048713regulation of oligodendrocyte differentiation14
GO:0006488dolichol-linked oligosaccharide biosynthetic process132
GO:0000212meiotic spindle organization14
GO:0048821erythrocyte development115
GO:0031095platelet dense tubular network membrane19
GO:0005730nucleolus691641
GO:0031755Edg-2 lysophosphatidic acid receptor binding12
GO:0006935chemotaxis3105
GO:0006874cellular calcium ion homeostasis170
GO:0031527filopodium membrane117
GO:0030057desmosome123
GO:0001055RNA polymerase II activity38
GO:0007612learning145
GO:0030163protein catabolic process122
GO:0016992lipoate synthase activity11
GO:0010871negative regulation of receptor biosynthetic process13
GO:0048255mRNA stabilization212
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator214
GO:0005790smooth endoplasmic reticulum122
GO:0019369arachidonic acid metabolic process242
GO:0030130clathrin coat of trans-Golgi network vesicle36
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus117
GO:0019901protein kinase binding21317
GO:0006541glutamine metabolic process117
GO:0046627negative regulation of insulin receptor signaling pathway123
GO:0009791post-embryonic development273
GO:0005911cell-cell junction4136
GO:0003823antigen binding122
GO:0032790ribosome disassembly17
GO:0000209protein polyubiquitination20116
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway426
GO:0060632regulation of microtubule-based movement13
GO:0051081nuclear envelope disassembly22
GO:0038027apolipoprotein A-I-mediated signaling pathway14
GO:0008066glutamate receptor activity111
GO:0042176regulation of protein catabolic process316
GO:0043011myeloid dendritic cell differentiation115
GO:0070914UV-damage excision repair27
GO:0005788endoplasmic reticulum lumen1145
GO:0017048Rho GTPase binding131
GO:0034124regulation of MyD88-dependent toll-like receptor signaling pathway12
GO:0046982protein heterodimerization activity13380
GO:0016567protein ubiquitination5295
GO:0045785positive regulation of cell adhesion440
GO:0006450regulation of translational fidelity29
GO:0045155electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity12
GO:0048284organelle fusion11
GO:0048268clathrin coat assembly113
GO:0034704calcium channel complex122
GO:0006684sphingomyelin metabolic process14
GO:0007186G-protein coupled receptor signaling pathway7289
GO:0060171stereocilium membrane12
GO:0016363nuclear matrix1291
GO:0035098ESC/E(Z) complex115
GO:0042169SH2 domain binding130
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic process12
GO:0070545PeBoW complex13
GO:0001657ureteric bud development138
GO:0005685U1 snRNP114
GO:0060076excitatory synapse118
GO:0031623receptor internalization231
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity259
GO:0015935small ribosomal subunit117
GO:0071346cellular response to interferon-gamma123
GO:0006428isoleucyl-tRNA aminoacylation12
GO:0033197response to vitamin E19
GO:0051668localization within membrane12
GO:0071850mitotic cell cycle arrest110
GO:0003923GPI-anchor transamidase activity15
GO:0001106RNA polymerase II transcription corepressor activity121
GO:0022028tangential migration from the subventricular zone to the olfactory bulb13
GO:0006413translational initiation17131
GO:0034612response to tumor necrosis factor227
GO:0030198extracellular matrix organization4283
GO:0004831tyrosine-tRNA ligase activity12
GO:0019731antibacterial humoral response116
GO:0005759mitochondrial matrix14228
GO:0042393histone binding169
GO:0001739sex chromatin17
GO:0002161aminoacyl-tRNA editing activity27
GO:0010226response to lithium ion210
GO:0033077T cell differentiation in thymus233
GO:0043195terminal bouton141
GO:0046474glycerophospholipid biosynthetic process470
GO:0010745negative regulation of macrophage derived foam cell differentiation213
GO:0006325chromatin organization5118
GO:0000015phosphopyruvate hydratase complex23
GO:0004506squalene monooxygenase activity11
GO:0005198structural molecule activity5150
GO:0033630positive regulation of cell adhesion mediated by integrin111
GO:0042026protein refolding215
GO:0051603proteolysis involved in cellular protein catabolic process216
GO:0000466maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)12
GO:0034185apolipoprotein binding114
GO:0019408dolichol biosynthetic process11
GO:0070371ERK1 and ERK2 cascade117
GO:0071310cellular response to organic substance117
GO:0046677response to antibiotic231
GO:0004860protein kinase inhibitor activity221
GO:0017080sodium channel regulator activity121
GO:0060048cardiac muscle contraction139
GO:0016604nuclear body231
GO:0021955central nervous system neuron axonogenesis15
GO:0032947protein complex scaffold131
GO:0005161platelet-derived growth factor receptor binding114
GO:0020037heme binding293
GO:0015908fatty acid transport18
GO:0006782protoporphyrinogen IX biosynthetic process19
GO:0008289lipid binding1106
GO:0034641cellular nitrogen compound metabolic process20171
GO:0032402melanosome transport120
GO:0033153T cell receptor V(D)J recombination15
GO:0046034ATP metabolic process115
GO:0048786presynaptic active zone121
GO:0006284base-excision repair337
GO:0060026convergent extension15
GO:0000139Golgi membrane3361
GO:0048156tau protein binding19
GO:0014042positive regulation of neuron maturation13
GO:0006921cellular component disassembly involved in execution phase of apoptosis547
GO:0005923tight junction186
GO:0030665clathrin-coated vesicle membrane213
GO:0008270zinc ion binding12997
GO:0047496vesicle transport along microtubule212
GO:0046512sphingosine biosynthetic process14
GO:0072284metanephric S-shaped body morphogenesis15
GO:0002037negative regulation of L-glutamate transport11
GO:0000718nucleotide-excision repair, DNA damage removal421
GO:0007420brain development2167
GO:0043923positive regulation by host of viral transcription211
GO:0001842neural fold formation13
GO:0060083smooth muscle contraction involved in micturition13
GO:0060766negative regulation of androgen receptor signaling pathway113
GO:0019432triglyceride biosynthetic process330
GO:0005019platelet-derived growth factor beta-receptor activity11
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway138
GO:0031965nuclear membrane3168
GO:0001755neural crest cell migration228
GO:0019003GDP binding247
GO:0048709oligodendrocyte differentiation123
GO:0005622intracellular6207
GO:0050774negative regulation of dendrite morphogenesis16
GO:0006364rRNA processing694
GO:0032609interferon-gamma production19
GO:0090303positive regulation of wound healing110
GO:0071733transcriptional activation by promoter-enhancer looping13
GO:0030325adrenal gland development121
GO:0005637nuclear inner membrane225
GO:0007219Notch signaling pathway5120
GO:1903543positive regulation of exosomal secretion112
GO:0007399nervous system development5231
GO:0005524ATP binding601298
GO:0042645mitochondrial nucleoid137
GO:0016049cell growth149
GO:0044281small molecule metabolic process581211
GO:0008333endosome to lysosome transport129
GO:0033180proton-transporting V-type ATPase, V1 domain27
GO:0071169establishment of protein localization to chromatin15
GO:0008076voltage-gated potassium channel complex154
GO:0045794negative regulation of cell volume12
GO:0048261negative regulation of receptor-mediated endocytosis16
GO:0001895retina homeostasis134
GO:0010508positive regulation of autophagy122
GO:0046716muscle cell cellular homeostasis116
GO:0007020microtubule nucleation114
GO:0006228UTP biosynthetic process19
GO:0006297nucleotide-excision repair, DNA gap filling322
GO:0005844polysome423
GO:0043687post-translational protein modification5162
GO:0030867rough endoplasmic reticulum membrane27
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors234
GO:0034976response to endoplasmic reticulum stress151
GO:0030054cell junction5336
GO:0039692single stranded viral RNA replication via double stranded DNA intermediate12
GO:0014002astrocyte development111
GO:0032355response to estradiol571
GO:0000731DNA synthesis involved in DNA repair110
GO:0003682chromatin binding11327
GO:0035116embryonic hindlimb morphogenesis130
GO:0008045motor neuron axon guidance119
GO:0019722calcium-mediated signaling139
GO:0000049tRNA binding434
GO:0001541ovarian follicle development137
GO:0001933negative regulation of protein phosphorylation236
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding553
GO:0051665membrane raft localization11
GO:0005544calcium-dependent phospholipid binding230
GO:0016042lipid catabolic process248
GO:0003714transcription corepressor activity8178
GO:0051926negative regulation of calcium ion transport112
GO:0038089positive regulation of cell migration by vascular endothelial growth factor signaling pathway11
GO:0007194negative regulation of adenylate cyclase activity121
GO:0003009skeletal muscle contraction117
GO:0045211postsynaptic membrane1170
GO:0001835blastocyst hatching24
GO:0051276chromosome organization316
GO:0010976positive regulation of neuron projection development158
GO:0030111regulation of Wnt signaling pathway112
GO:0031467Cul7-RING ubiquitin ligase complex14
GO:0006811ion transport1107
GO:0006900membrane budding15
GO:0032590dendrite membrane114
GO:0007249I-kappaB kinase/NF-kappaB signaling241
GO:0007605sensory perception of sound1104
GO:0033762response to glucagon111
GO:0048025negative regulation of mRNA splicing, via spliceosome115
GO:0022627cytosolic small ribosomal subunit439
GO:0033179proton-transporting V-type ATPase, V0 domain15
GO:0016791phosphatase activity118
GO:0031683G-protein beta/gamma-subunit complex binding121
GO:0010923negative regulation of phosphatase activity148
GO:0008201heparin binding4122
GO:0008543fibroblast growth factor receptor signaling pathway9156
GO:0045647negative regulation of erythrocyte differentiation17
GO:1990258histone glutamine methylation11
GO:0009055electron carrier activity165
GO:0001222transcription corepressor binding17
GO:00044301-phosphatidylinositol 4-kinase activity14
GO:0006749glutathione metabolic process227
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane125
GO:0007266Rho protein signal transduction247
GO:0031334positive regulation of protein complex assembly213
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding171
GO:0006656phosphatidylcholine biosynthetic process222
GO:0007595lactation239
GO:0071803positive regulation of podosome assembly15
GO:0005536glucose binding18
GO:0035584calcium-mediated signaling using intracellular calcium source112
GO:0007339binding of sperm to zona pellucida125
GO:0005055laminin receptor activity12
GO:0035234ectopic germ cell programmed cell death17
GO:0000166nucleotide binding5259
GO:0006610ribosomal protein import into nucleus14
GO:0018108peptidyl-tyrosine phosphorylation7132
GO:0004715non-membrane spanning protein tyrosine kinase activity442
GO:0048854brain morphogenesis115
GO:0000785chromatin473
GO:0006356regulation of transcription from RNA polymerase I promoter26
GO:0048813dendrite morphogenesis130
GO:0045814negative regulation of gene expression, epigenetic17
GO:0008013beta-catenin binding360
GO:0043380regulation of memory T cell differentiation11
GO:0045298tubulin complex13
GO:0006506GPI anchor biosynthetic process118
GO:0031410cytoplasmic vesicle1103
GO:2000536negative regulation of entry of bacterium into host cell11
GO:0005801cis-Golgi network133
GO:0048568embryonic organ development114
GO:0045471response to ethanol386
GO:0070063RNA polymerase binding19
GO:0036464cytoplasmic ribonucleoprotein granule422
GO:1903077negative regulation of protein localization to plasma membrane14
GO:0006766vitamin metabolic process171
GO:0006270DNA replication initiation622
GO:0044130negative regulation of growth of symbiont in host117
GO:0006508proteolysis9378
GO:0071380cellular response to prostaglandin E stimulus19
GO:0008266poly(U) RNA binding113
GO:0000082G1/S transition of mitotic cell cycle32149
GO:0004666prostaglandin-endoperoxide synthase activity12
GO:0090336positive regulation of brown fat cell differentiation13
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process13
GO:1901214regulation of neuron death112
GO:0070936protein K48-linked ubiquitination244
GO:1901558response to metformin11
GO:0090382phagosome maturation536
GO:2000010positive regulation of protein localization to cell surface26
GO:0034465response to carbon monoxide14
GO:0031594neuromuscular junction145
GO:0017144drug metabolic process118
GO:0045823positive regulation of heart contraction15
GO:0031947negative regulation of glucocorticoid biosynthetic process11
GO:0002026regulation of the force of heart contraction117
GO:0005890sodium:potassium-exchanging ATPase complex110
GO:0032307negative regulation of prostaglandin secretion11
GO:0051131chaperone-mediated protein complex assembly113
GO:0050473arachidonate 15-lipoxygenase activity11
GO:0021756striatum development110
GO:0006888ER to Golgi vesicle-mediated transport253
GO:0070012oligopeptidase activity11
GO:0031957very long-chain fatty acid-CoA ligase activity17
GO:0008083growth factor activity1141
GO:0060100positive regulation of phagocytosis, engulfment15
GO:0042562hormone binding116
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process344
GO:0050796regulation of insulin secretion481
GO:0090201negative regulation of release of cytochrome c from mitochondria116
GO:0051443positive regulation of ubiquitin-protein transferase activity112
GO:0003756protein disulfide isomerase activity122
GO:0051865protein autoubiquitination141
GO:0015078hydrogen ion transmembrane transporter activity319
GO:0001525angiogenesis4191
GO:0030136clathrin-coated vesicle442
GO:0006091generation of precursor metabolites and energy350
GO:0060546negative regulation of necroptotic process17
GO:0051974negative regulation of telomerase activity28
GO:0010107potassium ion import113
GO:0000018regulation of DNA recombination16
GO:0031333negative regulation of protein complex assembly114
GO:0031252cell leading edge428
GO:0003677DNA binding281218
GO:2000230negative regulation of pancreatic stellate cell proliferation11
GO:0071670smooth muscle cell chemotaxis12
GO:0048009insulin-like growth factor receptor signaling pathway114
GO:0090383phagosome acidification13
GO:0010666positive regulation of cardiac muscle cell apoptotic process15
GO:0017124SH3 domain binding3113
GO:0010506regulation of autophagy123
GO:0010811positive regulation of cell-substrate adhesion231
GO:0002502peptide antigen assembly with MHC class I protein complex11
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process136
GO:0006810transport1242
GO:0004872receptor activity2189
GO:0006939smooth muscle contraction117
GO:0021846cell proliferation in forebrain110
GO:0016239positive regulation of macroautophagy112
GO:0017025TBP-class protein binding317
GO:0090305nucleic acid phosphodiester bond hydrolysis153
GO:0048010vascular endothelial growth factor receptor signaling pathway120
GO:0005682U5 snRNP16
GO:0000045autophagic vacuole assembly126
GO:0071392cellular response to estradiol stimulus118
GO:0016310phosphorylation490
GO:0006349regulation of gene expression by genetic imprinting115
GO:0000733DNA strand renaturation17
GO:0051028mRNA transport252
GO:0045822negative regulation of heart contraction16
GO:0017157regulation of exocytosis218
GO:0007051spindle organization111
GO:0004888transmembrane signaling receptor activity195
GO:0001756somitogenesis233
GO:0072089stem cell proliferation17
GO:0009653anatomical structure morphogenesis383
GO:0004221ubiquitin thiolesterase activity136
GO:0044548S100 protein binding111
GO:0005504fatty acid binding113
GO:0048015phosphatidylinositol-mediated signaling7114
GO:0030898actin-dependent ATPase activity112
GO:0043276anoikis15
GO:0001849complement component C1q binding17
GO:0042149cellular response to glucose starvation117
GO:0048546digestive tract morphogenesis114
GO:0035255ionotropic glutamate receptor binding116
GO:0042633hair cycle18
GO:0060021palate development172
GO:0031463Cul3-RING ubiquitin ligase complex323
GO:0006974cellular response to DNA damage stimulus8151
GO:1902108regulation of mitochondrial membrane permeability involved in apoptotic process16
GO:0031209SCAR complex18
GO:0043484regulation of RNA splicing122
GO:0043236laminin binding123
GO:0035861site of double-strand break118
GO:0032077positive regulation of deoxyribonuclease activity11
GO:0030246carbohydrate binding1134
GO:0048387negative regulation of retinoic acid receptor signaling pathway28
GO:0031100organ regeneration450
GO:0045668negative regulation of osteoblast differentiation136
GO:0008180COP9 signalosome134
GO:0007165signal transduction24907
GO:0051409response to nitrosative stress14
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling151
GO:0005669transcription factor TFIID complex122
GO:0046777protein autophosphorylation7158
GO:0070243regulation of thymocyte apoptotic process11
GO:0019372lipoxygenase pathway19
GO:0002634regulation of germinal center formation14
GO:0000151ubiquitin ligase complex163
GO:0051726regulation of cell cycle597
GO:0006629lipid metabolic process590
GO:0001968fibronectin binding225
GO:0048873homeostasis of number of cells within a tissue120
GO:0000320re-entry into mitotic cell cycle23
GO:0034237protein kinase A regulatory subunit binding110
GO:0003016respiratory system process18
GO:0005901caveola562
GO:0031113regulation of microtubule polymerization12
GO:0035338long-chain fatty-acyl-CoA biosynthetic process313
GO:0006101citrate metabolic process16
GO:0050853B cell receptor signaling pathway129
GO:0051574positive regulation of histone H3-K9 methylation15
GO:0006954inflammatory response7277
GO:0005543phospholipid binding167
GO:0017059serine C-palmitoyltransferase complex13
GO:0006554lysine catabolic process28
GO:0030176integral component of endoplasmic reticulum membrane253
GO:0019083viral transcription1081
GO:0008134transcription factor binding8242
GO:0034774secretory granule lumen112
GO:0005783endoplasmic reticulum10556
GO:0060337type I interferon signaling pathway258
GO:0003746translation elongation factor activity317
GO:0071944cell periphery123
GO:0007263nitric oxide mediated signal transduction117
GO:0004716receptor signaling protein tyrosine kinase activity19
GO:0018738S-formylglutathione hydrolase activity11
GO:0019058viral life cycle13115
GO:0043065positive regulation of apoptotic process10268
GO:0030426growth cone596
GO:0045087innate immune response24596
GO:0055037recycling endosome270
GO:0009612response to mechanical stimulus250
GO:0070852cell body fiber15
GO:0032855positive regulation of Rac GTPase activity135
GO:0048273mitogen-activated protein kinase p38 binding14
GO:0016032viral process55534
GO:0001666response to hypoxia5149
GO:0010042response to manganese ion16
GO:0008022protein C-terminus binding5161
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress223
GO:0061298retina vasculature development in camera-type eye17
GO:0002227innate immune response in mucosa116
GO:0006367transcription initiation from RNA polymerase II promoter8184
GO:0034394protein localization to cell surface118
GO:0048294negative regulation of isotype switching to IgE isotypes13
GO:0045120pronucleus211
GO:0045595regulation of cell differentiation121
GO:0045022early endosome to late endosome transport115
GO:0044308axonal spine13
GO:0050872white fat cell differentiation110
GO:0035556intracellular signal transduction9303
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane127
GO:0050995negative regulation of lipid catabolic process113
GO:0006470protein dephosphorylation198
GO:0001934positive regulation of protein phosphorylation6104
GO:0060416response to growth hormone17
GO:0005871kinesin complex344
GO:0043085positive regulation of catalytic activity161
GO:0032549ribonucleoside binding24
GO:0004298threonine-type endopeptidase activity819
GO:0002039p53 binding755
GO:0009374biotin binding15
GO:0006366transcription from RNA polymerase II promoter10419
GO:0031258lamellipodium membrane216
GO:0004821histidine-tRNA ligase activity12
GO:0006424glutamyl-tRNA aminoacylation12
GO:0043401steroid hormone mediated signaling pathway151
GO:0036035osteoclast development22
GO:0031116positive regulation of microtubule polymerization111
GO:0034644cellular response to UV530
GO:0008090retrograde axon cargo transport26
GO:0071157negative regulation of cell cycle arrest112
GO:0005604basement membrane166
GO:0046390ribose phosphate biosynthetic process11
GO:0031512motile primary cilium18
GO:0042826histone deacetylase binding272
GO:0045494photoreceptor cell maintenance124
GO:0004623phospholipase A2 activity111
GO:0032784regulation of DNA-templated transcription, elongation112
GO:0075733intracellular transport of virus317
GO:0000050urea cycle19
GO:0051412response to corticosterone124
GO:0000502proteasome complex1758
GO:0000122negative regulation of transcription from RNA polymerase II promoter16570
GO:0090398cellular senescence118
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation125
GO:0048265response to pain114
GO:0043202lysosomal lumen163
GO:0046961proton-transporting ATPase activity, rotational mechanism315
GO:0043525positive regulation of neuron apoptotic process246
GO:0050900leukocyte migration1110
GO:0051090regulation of sequence-specific DNA binding transcription factor activity120
GO:0032526response to retinoic acid246
GO:0032869cellular response to insulin stimulus363
GO:0035033histone deacetylase regulator activity13
GO:0006464cellular protein modification process284
GO:2001244positive regulation of intrinsic apoptotic signaling pathway233
GO:0043537negative regulation of blood vessel endothelial cell migration112
GO:0043068positive regulation of programmed cell death18
GO:0006283transcription-coupled nucleotide-excision repair746
GO:0042127regulation of cell proliferation3109
GO:0007494midgut development18
GO:0006021inositol biosynthetic process13
GO:0017148negative regulation of translation240
GO:0005507copper ion binding246
GO:0033144negative regulation of intracellular steroid hormone receptor signaling pathway12
GO:0071902positive regulation of protein serine/threonine kinase activity126
GO:0043125ErbB-3 class receptor binding14
GO:0044822poly(A) RNA binding491056
GO:0006323DNA packaging15
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity143
GO:0010039response to iron ion112
GO:0010628positive regulation of gene expression5146
GO:0035902response to immobilization stress117
GO:0002876positive regulation of chronic inflammatory response to antigenic stimulus12
GO:0035249synaptic transmission, glutamatergic132
GO:0008380RNA splicing11228
GO:0006983ER overload response29
GO:0005930axoneme139
GO:0045787positive regulation of cell cycle122
GO:0097546ciliary base18
GO:0003723RNA binding20342
GO:0030690Noc1p-Noc2p complex11
GO:0022625cytosolic large ribosomal subunit649
GO:0032094response to food115
GO:0005741mitochondrial outer membrane7105
GO:0032133chromosome passenger complex14
GO:2001237negative regulation of extrinsic apoptotic signaling pathway135
GO:0010165response to X-ray319
GO:0071168protein localization to chromatin15
GO:0061024membrane organization7145
GO:0009925basal plasma membrane127
GO:0045717negative regulation of fatty acid biosynthetic process19
GO:0048661positive regulation of smooth muscle cell proliferation449
GO:0005719nuclear euchromatin219
GO:0035024negative regulation of Rho protein signal transduction111
GO:0017081chloride channel regulator activity15
GO:0035441cell migration involved in vasculogenesis12
GO:0032715negative regulation of interleukin-6 production120
GO:0004602glutathione peroxidase activity113
GO:2000036regulation of stem cell maintenance111
GO:0071363cellular response to growth factor stimulus142
GO:0055119relaxation of cardiac muscle112
GO:0046985positive regulation of hemoglobin biosynthetic process12
GO:0034719SMN-Sm protein complex116
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex16
GO:0046686response to cadmium ion222
GO:0046488phosphatidylinositol metabolic process110
GO:0048240sperm capacitation19
GO:0050764regulation of phagocytosis16
GO:0071285cellular response to lithium ion214
GO:0005827polar microtubule15
GO:0005643nuclear pore457
GO:0051534negative regulation of NFAT protein import into nucleus14
GO:0003674molecular_function4444
GO:0045994positive regulation of translational initiation by iron11
GO:0006511ubiquitin-dependent protein catabolic process5126
GO:0043967histone H4 acetylation327
GO:0043565sequence-specific DNA binding6346
GO:0050830defense response to Gram-positive bacterium245
GO:0051384response to glucocorticoid262
GO:0004075biotin carboxylase activity15
GO:0007254JNK cascade349
GO:0034333adherens junction assembly17
GO:0032232negative regulation of actin filament bundle assembly14
GO:0005726perichromatin fibrils13
GO:0070527platelet aggregation238
GO:0006879cellular iron ion homeostasis451
GO:0019287isopentenyl diphosphate biosynthetic process, mevalonate pathway13
GO:0003896DNA primase activity24
GO:0004055argininosuccinate synthase activity11
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway271
GO:0006725cellular aromatic compound metabolic process12
GO:0005838proteasome regulatory particle712
GO:0006734NADH metabolic process14
GO:0006687glycosphingolipid metabolic process132
GO:0044205'de novo' UMP biosynthetic process13
GO:0007015actin filament organization237
GO:0006959humoral immune response147
GO:0005515protein binding1846024
GO:0022904respiratory electron transport chain185
GO:0000777condensed chromosome kinetochore468
GO:0007411axon guidance13319
GO:0070734histone H3-K27 methylation14
GO:0006778porphyrin-containing compound metabolic process118
GO:0006936muscle contraction287
GO:0030670phagocytic vesicle membrane347
GO:0019682glyceraldehyde-3-phosphate metabolic process11
GO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway17
GO:0070129regulation of mitochondrial translation13
GO:0042765GPI-anchor transamidase complex15
GO:0005811lipid particle247
GO:0005657replication fork318
GO:0051897positive regulation of protein kinase B signaling170
GO:0008637apoptotic mitochondrial changes121
GO:0032741positive regulation of interleukin-18 production13
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway261
GO:0019887protein kinase regulator activity14
GO:0005853eukaryotic translation elongation factor 1 complex24
GO:0071782endoplasmic reticulum tubular network14
GO:0045505dynein intermediate chain binding13
GO:0036270response to diuretic11
GO:0032728positive regulation of interferon-beta production122
GO:0042572retinol metabolic process114
GO:0042581specific granule111
GO:1901228positive regulation of transcription from RNA polymerase II promoter involved in heart development11
GO:0005123death receptor binding115
GO:0097504Gemini of coiled bodies110
GO:0051604protein maturation18
GO:0022604regulation of cell morphogenesis116
GO:0005686U2 snRNP14
GO:0005737cytoplasm1103767
GO:0043523regulation of neuron apoptotic process118
GO:0003407neural retina development15
GO:0033018sarcoplasmic reticulum lumen17
GO:0019869chloride channel inhibitor activity19
GO:0006914autophagy174
GO:0006006glucose metabolic process7118
GO:0042730fibrinolysis118
GO:0035749myelin sheath adaxonal region25
GO:0033601positive regulation of mammary gland epithelial cell proliferation14
GO:0016581NuRD complex116
GO:0016055Wnt signaling pathway7138
GO:0033690positive regulation of osteoblast proliferation17
GO:1990239steroid hormone binding13
GO:0005840ribosome158
GO:0000287magnesium ion binding4164
GO:0097192extrinsic apoptotic signaling pathway in absence of ligand335
GO:0030307positive regulation of cell growth369
GO:0010988regulation of low-density lipoprotein particle clearance13
GO:0006754ATP biosynthetic process118
GO:0002740negative regulation of cytokine secretion involved in immune response15
GO:0010046response to mycotoxin12
GO:0000165MAPK cascade272
GO:0031532actin cytoskeleton reorganization141
GO:0010243response to organonitrogen compound317
GO:0030488tRNA methylation111
GO:0009750response to fructose12
GO:0005658alpha DNA polymerase:primase complex24
GO:0006853carnitine shuttle18
GO:0016925protein sumoylation125
GO:0030049muscle filament sliding138
GO:0002028regulation of sodium ion transport113
GO:0016023cytoplasmic membrane-bounded vesicle5105
GO:0050728negative regulation of inflammatory response156
GO:0016272prefoldin complex19
GO:0002576platelet degranulation482
GO:0006362transcription elongation from RNA polymerase I promoter323
GO:0007080mitotic metaphase plate congression213
GO:0007173epidermal growth factor receptor signaling pathway12189
GO:0051898negative regulation of protein kinase B signaling127
GO:0042493response to drug13284
GO:0005834heterotrimeric G-protein complex134
GO:0043524negative regulation of neuron apoptotic process2117
GO:0061098positive regulation of protein tyrosine kinase activity121
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 protein15
GO:0008139nuclear localization sequence binding39
GO:0018119peptidyl-cysteine S-nitrosylation13
GO:0006474N-terminal protein amino acid acetylation16
GO:0006767water-soluble vitamin metabolic process168
GO:0006855drug transmembrane transport110
GO:0070588calcium ion transmembrane transport295
GO:0006986response to unfolded protein250
GO:0032227negative regulation of synaptic transmission, dopaminergic12
GO:0045629negative regulation of T-helper 2 cell differentiation12
GO:0001961positive regulation of cytokine-mediated signaling pathway17
GO:0008353RNA polymerase II carboxy-terminal domain kinase activity116
GO:0000028ribosomal small subunit assembly17
GO:0034138toll-like receptor 3 signaling pathway379
GO:00515383 iron, 4 sulfur cluster binding12
GO:0004820glycine-tRNA ligase activity11
GO:1900748positive regulation of vascular endothelial growth factor signaling pathway12
GO:0005666DNA-directed RNA polymerase III complex317
GO:0010521telomerase inhibitor activity13
GO:0005802trans-Golgi network2110
GO:0031325positive regulation of cellular metabolic process18
GO:0008963phospho-N-acetylmuramoyl-pentapeptide-transferase activity11
GO:0030177positive regulation of Wnt signaling pathway327
GO:0007603phototransduction, visible light178
GO:1901525negative regulation of macromitophagy12
GO:0000245spliceosomal complex assembly121
GO:0006383transcription from RNA polymerase III promoter339
GO:0046513ceramide biosynthetic process216
GO:0051533positive regulation of NFAT protein import into nucleus14
GO:0071316cellular response to nicotine18
GO:0007528neuromuscular junction development132
GO:0008286insulin receptor signaling pathway7142
GO:0060539diaphragm development17
GO:0048011neurotrophin TRK receptor signaling pathway15269
GO:0006742NADP catabolic process11
GO:0007067mitotic nuclear division14227
GO:0051267CP2 mannose-ethanolamine phosphotransferase activity11
GO:0000792heterochromatin222
GO:0030968endoplasmic reticulum unfolded protein response479
GO:0005885Arp2/3 protein complex17
GO:0004149dihydrolipoyllysine-residue succinyltransferase activity11
GO:0045010actin nucleation13
GO:0004128cytochrome-b5 reductase activity, acting on NAD(P)H16
GO:0002819regulation of adaptive immune response15
GO:0004596peptide alpha-N-acetyltransferase activity15
GO:0006346methylation-dependent chromatin silencing16
GO:0001764neuron migration393
GO:0010827regulation of glucose transport130
GO:0060052neurofilament cytoskeleton organization15
GO:0002176male germ cell proliferation12
GO:0042994cytoplasmic sequestering of transcription factor113
GO:0019395fatty acid oxidation111
GO:0016446somatic hypermutation of immunoglobulin genes19
GO:0005875microtubule associated complex228
GO:0005246calcium channel regulator activity118
GO:0004687myosin light chain kinase activity13
GO:0005576extracellular region4942
GO:2000138positive regulation of cell proliferation involved in heart morphogenesis14
GO:0045160myosin I complex11
GO:0008156negative regulation of DNA replication120
GO:0000722telomere maintenance via recombination525
GO:0021860pyramidal neuron development16
GO:0032707negative regulation of interleukin-23 production12
GO:0042803protein homodimerization activity12595
GO:0035965cardiolipin acyl-chain remodeling15
GO:0005905coated pit350
GO:0051082unfolded protein binding593
GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulin15
GO:0009615response to virus5126
GO:0060044negative regulation of cardiac muscle cell proliferation18
GO:0000149SNARE binding118
GO:0007214gamma-aminobutyric acid signaling pathway119
GO:0032479regulation of type I interferon production113
GO:0070182DNA polymerase binding28
GO:0001054RNA polymerase I activity311
GO:0000932cytoplasmic mRNA processing body354
GO:0030955potassium ion binding17
GO:0043023ribosomal large subunit binding15
GO:0051101regulation of DNA binding15
GO:0003700sequence-specific DNA binding transcription factor activity11699
GO:0001047core promoter binding245
GO:0033993response to lipid26
GO:0044309neuron spine13
GO:0051097negative regulation of helicase activity13
GO:0010863positive regulation of phospholipase C activity18
GO:0051592response to calcium ion355
GO:0042908xenobiotic transport15
GO:0043623cellular protein complex assembly115
GO:0019433triglyceride catabolic process119
GO:0060073micturition12
GO:0007589body fluid secretion110
GO:0004634phosphopyruvate hydratase activity23
GO:0042092type 2 immune response14
GO:0004467long-chain fatty acid-CoA ligase activity19
GO:0035987endodermal cell differentiation126
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis17
GO:0016471vacuolar proton-transporting V-type ATPase complex17
GO:0002020protease binding474
GO:0016428tRNA (cytosine-5-)-methyltransferase activity11
GO:0048662negative regulation of smooth muscle cell proliferation128
GO:0000187activation of MAPK activity590
GO:0035518histone H2A monoubiquitination311
GO:0090023positive regulation of neutrophil chemotaxis118
GO:0046626regulation of insulin receptor signaling pathway13
GO:0005154epidermal growth factor receptor binding126
GO:0008219cell death128
GO:0009986cell surface11402
GO:0003713transcription coactivator activity10237
GO:0031466Cul5-RING ubiquitin ligase complex16
GO:0000794condensed nuclear chromosome224
GO:0051881regulation of mitochondrial membrane potential220
GO:0070419nonhomologous end joining complex16
GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activity13
GO:0047374methylumbelliferyl-acetate deacetylase activity12
GO:0019903protein phosphatase binding462
GO:0007166cell surface receptor signaling pathway3147
GO:0008584male gonad development375
GO:0016605PML body388
GO:0005675holo TFIIH complex111
GO:0046965retinoid X receptor binding115
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process777
GO:0006690icosanoid metabolic process15
GO:0071839apoptotic process in bone marrow11
GO:0004303estradiol 17-beta-dehydrogenase activity15
GO:0006814sodium ion transport149
GO:0043388positive regulation of DNA binding124
GO:0070557PCNA-p21 complex12
GO:0032516positive regulation of phosphoprotein phosphatase activity110
GO:0032700negative regulation of interleukin-17 production110
GO:0051023regulation of immunoglobulin secretion15
GO:0034080CENP-A containing nucleosome assembly125
GO:0045416positive regulation of interleukin-8 biosynthetic process17
GO:0001942hair follicle development135
GO:0090129positive regulation of synapse maturation110
GO:0010891negative regulation of sequestering of triglyceride15
GO:0006275regulation of DNA replication212
GO:0032956regulation of actin cytoskeleton organization130
GO:0004683calmodulin-dependent protein kinase activity119
GO:0070584mitochondrion morphogenesis117
GO:0055106ubiquitin-protein transferase regulator activity13
GO:0035877death effector domain binding14
GO:0031915positive regulation of synaptic plasticity25
GO:0051259protein oligomerization139
GO:0043000Golgi to plasma membrane CFTR protein transport11
GO:0060336negative regulation of interferon-gamma-mediated signaling pathway15
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator230
GO:0045740positive regulation of DNA replication236
GO:0045296cadherin binding124
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity226
GO:0030900forebrain development249
GO:0019902phosphatase binding242
GO:0001953negative regulation of cell-matrix adhesion112
GO:0035791platelet-derived growth factor receptor-beta signaling pathway12
GO:0050885neuromuscular process controlling balance140
GO:0043297apical junction assembly17
GO:0015074DNA integration17
GO:0030331estrogen receptor binding227
GO:0006104succinyl-CoA metabolic process14
GO:0071407cellular response to organic cyclic compound238
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle222
GO:0006102isocitrate metabolic process15
GO:0045202synapse3136
GO:0048705skeletal system morphogenesis124
GO:0045165cell fate commitment144
GO:0015909long-chain fatty acid transport17
GO:0005249voltage-gated potassium channel activity128
GO:0005001transmembrane receptor protein tyrosine phosphatase activity118
GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity136
GO:0002027regulation of heart rate129
GO:0001775cell activation17
GO:0043647inositol phosphate metabolic process139
GO:0006887exocytosis164
GO:0048365Rac GTPase binding229
GO:0000055ribosomal large subunit export from nucleus14
GO:0090090negative regulation of canonical Wnt signaling pathway186
GO:0071499cellular response to laminar fluid shear stress17
GO:0000961negative regulation of mitochondrial RNA catabolic process12
GO:0060314regulation of ryanodine-sensitive calcium-release channel activity112
GO:0003989acetyl-CoA carboxylase activity12
GO:0006363termination of RNA polymerase I transcription324
GO:0035729cellular response to hepatocyte growth factor stimulus17
GO:0005925focal adhesion19366
GO:0051660establishment of centrosome localization11
GO:0047497mitochondrion transport along microtubule39
GO:0051290protein heterotetramerization211
GO:0009107lipoate biosynthetic process11
GO:0035189Rb-E2F complex14
GO:0042752regulation of circadian rhythm237
GO:0006487protein N-linked glycosylation120
GO:0030836positive regulation of actin filament depolymerization26
GO:0032369negative regulation of lipid transport14
GO:0030866cortical actin cytoskeleton organization119
GO:0007094mitotic spindle assembly checkpoint431
GO:0036353histone H2A-K119 monoubiquitination11
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor13
GO:00084083'-5' exonuclease activity116
GO:0060453regulation of gastric acid secretion11
GO:0000730DNA recombinase assembly15
GO:0051208sequestering of calcium ion14
GO:0006927transformed cell apoptotic process16
GO:0004333fumarate hydratase activity11
GO:0034684integrin alphav-beta5 complex12
GO:0005773vacuole17
GO:0005638lamin filament15
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complex14
GO:0002467germinal center formation18
GO:0045444fat cell differentiation247
GO:2000369regulation of clathrin-mediated endocytosis15
GO:0031966mitochondrial membrane155
GO:0032201telomere maintenance via semi-conservative replication521
GO:0070534protein K63-linked ubiquitination131
GO:0000220vacuolar proton-transporting V-type ATPase, V0 domain14
GO:0000053argininosuccinate metabolic process11
GO:0071356cellular response to tumor necrosis factor157
GO:0050730regulation of peptidyl-tyrosine phosphorylation112
GO:0035633maintenance of blood-brain barrier11
GO:0016874ligase activity1214
GO:0032405MutLalpha complex binding16
GO:0048730epidermis morphogenesis15
GO:0021540corpus callosum morphogenesis12
GO:0005815microtubule organizing center5109
GO:0015630microtubule cytoskeleton4110
GO:0071400cellular response to oleic acid12
GO:0051044positive regulation of membrane protein ectodomain proteolysis114
GO:0071542dopaminergic neuron differentiation112
GO:0000808origin recognition complex16
GO:0001664G-protein coupled receptor binding138
GO:0014820tonic smooth muscle contraction11
GO:0055086nucleobase-containing small molecule metabolic process270
GO:0007052mitotic spindle organization222
GO:0032321positive regulation of Rho GTPase activity182
GO:0006833water transport131
GO:0030674protein binding, bridging151
GO:0051434BH3 domain binding14
GO:0022417protein maturation by protein folding19
GO:0006972hyperosmotic response19
GO:0000281mitotic cytokinesis121
GO:0051879Hsp90 protein binding117
GO:0030730sequestering of triglyceride13
GO:0006897endocytosis8106
GO:0001838embryonic epithelial tube formation12
GO:0007070negative regulation of transcription from RNA polymerase II promoter during mitosis12
GO:2000379positive regulation of reactive oxygen species metabolic process223
GO:0019855calcium channel inhibitor activity110
GO:1900118negative regulation of execution phase of apoptosis16
GO:0042626ATPase activity, coupled to transmembrane movement of substances126
GO:0048511rhythmic process345
GO:0045943positive regulation of transcription from RNA polymerase I promoter16
GO:0050679positive regulation of epithelial cell proliferation154
GO:0030425dendrite3230
GO:0032588trans-Golgi network membrane234
GO:0032091negative regulation of protein binding132
GO:0044183protein binding involved in protein folding18
GO:0002199zona pellucida receptor complex110
GO:0072431signal transduction involved in mitotic G1 DNA damage checkpoint11
GO:0042110T cell activation342
GO:0055098response to low-density lipoprotein particle13
GO:0008021synaptic vesicle273
GO:0006094gluconeogenesis543
GO:0061574ASAP complex13
GO:0030027lamellipodium4125
GO:0043005neuron projection6157
GO:0007160cell-matrix adhesion382
GO:0034332adherens junction organization136
GO:0010693negative regulation of alkaline phosphatase activity14
GO:0006606protein import into nucleus230
GO:0045590negative regulation of regulatory T cell differentiation13
GO:0003688DNA replication origin binding26
GO:0006396RNA processing159
GO:0007059chromosome segregation462
GO:0006521regulation of cellular amino acid metabolic process1750
GO:0050901leukocyte tethering or rolling115
GO:1900026positive regulation of substrate adhesion-dependent cell spreading223
GO:2000134negative regulation of G1/S transition of mitotic cell cycle220
GO:0001012RNA polymerase II regulatory region DNA binding13
GO:0007405neuroblast proliferation116
GO:0035615clathrin adaptor activity28
GO:0005975carbohydrate metabolic process9253
GO:0060053neurofilament cytoskeleton12
GO:0006611protein export from nucleus325
GO:0097252oligodendrocyte apoptotic process12
GO:0017075syntaxin-1 binding119
GO:0008135translation factor activity, nucleic acid binding724
GO:003068690S preribosome14
GO:0060384innervation112
GO:0030122AP-2 adaptor complex210
GO:0018467formaldehyde dehydrogenase activity11
GO:0006953acute-phase response235
GO:0061136regulation of proteasomal protein catabolic process212
GO:0006337nucleosome disassembly317
GO:0070672response to interleukin-1513
GO:0070469respiratory chain15
GO:0043021ribonucleoprotein complex binding121
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity245
GO:0005881cytoplasmic microtubule140
GO:0050660flavin adenine dinucleotide binding254
GO:0006259DNA metabolic process219
GO:0004722protein serine/threonine phosphatase activity142
GO:0005109frizzled binding131
GO:0035867alphav-beta3 integrin-IGF-1-IGF1R complex11
GO:0005854nascent polypeptide-associated complex11
GO:0010310regulation of hydrogen peroxide metabolic process14
GO:0015030Cajal body344
GO:0005048signal sequence binding12
GO:0021831embryonic olfactory bulb interneuron precursor migration11
GO:0051156glucose 6-phosphate metabolic process17
GO:0016301kinase activity333
GO:0070979protein K11-linked ubiquitination626
GO:0045121membrane raft8156
GO:0051928positive regulation of calcium ion transport126
GO:0010734negative regulation of protein glutathionylation11
GO:00709353'-UTR-mediated mRNA stabilization212
GO:0050804regulation of synaptic transmission110
GO:1901379regulation of potassium ion transmembrane transport16
GO:0006099tricarboxylic acid cycle428
GO:0035235ionotropic glutamate receptor signaling pathway124
GO:1901621negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning15
GO:0010033response to organic substance227
GO:0001618virus receptor activity129
GO:0014911positive regulation of smooth muscle cell migration116
GO:0001889liver development477
GO:0072659protein localization to plasma membrane139
GO:0032966negative regulation of collagen biosynthetic process15
GO:0060996dendritic spine development16
GO:0001726ruffle480
GO:0070613regulation of protein processing18
GO:0006644phospholipid metabolic process5129
GO:0007268synaptic transmission6332
GO:0006955immune response1288
GO:0002309T cell proliferation involved in immune response16
GO:2000045regulation of G1/S transition of mitotic cell cycle110
GO:0016020membrane901681
GO:0032026response to magnesium ion112
GO:0019788NEDD8 ligase activity14
GO:0006654phosphatidic acid biosynthetic process121
GO:0071383cellular response to steroid hormone stimulus110
GO:0009611response to wounding152
GO:0000077DNA damage checkpoint127
GO:0015137citrate transmembrane transporter activity12
GO:0001652granular component14
GO:0050873brown fat cell differentiation229
GO:0016281eukaryotic translation initiation factor 4F complex29
GO:0010369chromocenter111
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway134
GO:0035887aortic smooth muscle cell differentiation12
GO:0034097response to cytokine150
GO:0003007heart morphogenesis134
GO:0001882nucleoside binding14
GO:0003994aconitate hydratase activity12
GO:0001042RNA polymerase I core binding11
GO:0006883cellular sodium ion homeostasis112
GO:0016328lateral plasma membrane146
GO:0036120cellular response to platelet-derived growth factor stimulus15
GO:0016254preassembly of GPI anchor in ER membrane115
GO:0009566fertilization125
GO:2000001regulation of DNA damage checkpoint15
GO:0043242negative regulation of protein complex disassembly14
GO:0016477cell migration5128
GO:0045786negative regulation of cell cycle139
GO:0071260cellular response to mechanical stimulus565
GO:0040008regulation of growth550
GO:0047485protein N-terminus binding586
GO:0006302double-strand break repair462
GO:0048016inositol phosphate-mediated signaling19
GO:0035357peroxisome proliferator activated receptor signaling pathway14
GO:0030018Z disc197
GO:0043039tRNA aminoacylation12
GO:0045651positive regulation of macrophage differentiation111
GO:0070301cellular response to hydrogen peroxide141
GO:0071174mitotic spindle checkpoint14
GO:0043203axon hillock17
GO:0045862positive regulation of proteolysis121
GO:0006468protein phosphorylation18460
GO:0090399replicative senescence110
GO:0033280response to vitamin D114
GO:0043277apoptotic cell clearance113
GO:0006886intracellular protein transport5171
GO:0008047enzyme activator activity139
GO:0090362positive regulation of platelet-derived growth factor production11
GO:0060041retina development in camera-type eye251
GO:0004180carboxypeptidase activity114
GO:0009952anterior/posterior pattern specification183
GO:0045116protein neddylation28
GO:0010629negative regulation of gene expression177
GO:0019941modification-dependent protein catabolic process15
GO:0007050cell cycle arrest9124
GO:0071320cellular response to cAMP140
GO:0007100mitotic centrosome separation24
GO:0031462Cul2-RING ubiquitin ligase complex27
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia326
GO:0042953lipoprotein transport112
GO:1990268response to gold nanoparticle12
GO:0030097hemopoiesis156
GO:0002439chronic inflammatory response to antigenic stimulus12
GO:0044297cell body246
GO:0046872metal ion binding251307
GO:0001948glycoprotein binding350
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1964
GO:0034660ncRNA metabolic process123
GO:0036148phosphatidylglycerol acyl-chain remodeling112
GO:0072369regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter12
GO:0032481positive regulation of type I interferon production661
GO:0007596blood coagulation18455
GO:0016486peptide hormone processing116
GO:0030274LIM domain binding17
GO:0021987cerebral cortex development342
GO:0005736DNA-directed RNA polymerase I complex312
GO:0032800receptor biosynthetic process13
GO:0045084positive regulation of interleukin-12 biosynthetic process17
GO:0034446substrate adhesion-dependent cell spreading236
GO:0042802identical protein binding20484
GO:0071872cellular response to epinephrine stimulus110
GO:0006334nucleosome assembly272
GO:0033598mammary gland epithelial cell proliferation19
GO:0006663platelet activating factor biosynthetic process14
GO:0071333cellular response to glucose stimulus133
GO:0007155cell adhesion6369
GO:0031201SNARE complex231
GO:0097284hepatocyte apoptotic process39
GO:0090385phagosome-lysosome fusion13
GO:0032733positive regulation of interleukin-10 production119
GO:0017091AU-rich element binding114
GO:0045773positive regulation of axon extension418
GO:0048168regulation of neuronal synaptic plasticity214
GO:0071242cellular response to ammonium ion12
GO:0005516calmodulin binding3160
GO:0070034telomeric RNA binding12
GO:0048872homeostasis of number of cells19
GO:0031012extracellular matrix2154
GO:1903506regulation of nucleic acid-templated transcription118
GO:0004725protein tyrosine phosphatase activity178
GO:0005017platelet-derived growth factor-activated receptor activity11
GO:0071364cellular response to epidermal growth factor stimulus121
GO:0006271DNA strand elongation involved in DNA replication730
GO:0043130ubiquitin binding145
GO:0000086G2/M transition of mitotic cell cycle9136
GO:0010951negative regulation of endopeptidase activity1104
GO:0006661phosphatidylinositol biosynthetic process252
GO:0050860negative regulation of T cell receptor signaling pathway113
GO:1901227negative regulation of transcription from RNA polymerase II promoter involved in heart development11
GO:0021794thalamus development111
GO:0036016cellular response to interleukin-315
GO:0048306calcium-dependent protein binding156
GO:0032729positive regulation of interferon-gamma production239
GO:0030330DNA damage response, signal transduction by p53 class mediator114
GO:0002326B cell lineage commitment24
GO:0060981cell migration involved in coronary angiogenesis11
GO:0016126sterol biosynthetic process26
GO:0005768endosome6169
GO:0001725stress fiber255
GO:2000077negative regulation of type B pancreatic cell development12
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent2072
GO:0001843neural tube closure474
GO:0004982N-formyl peptide receptor activity12
GO:0005215transporter activity2130
GO:0044772mitotic cell cycle phase transition11
GO:0051022Rho GDP-dissociation inhibitor binding12
GO:0005777peroxisome484
GO:0034451centriolar satellite115
GO:0001741XY body112
GO:0031065positive regulation of histone deacetylation19
GO:0016829lyase activity113
GO:0086064cell communication by electrical coupling involved in cardiac conduction212
GO:0030838positive regulation of actin filament polymerization234
GO:0016407acetyltransferase activity110
GO:0030155regulation of cell adhesion242
GO:0050849negative regulation of calcium-mediated signaling13
GO:0005952cAMP-dependent protein kinase complex19
GO:0001875lipopolysaccharide receptor activity15
GO:0072562blood microparticle3111
GO:0048538thymus development236
GO:0004807triose-phosphate isomerase activity11
GO:0006928cellular component movement791
GO:0015085calcium ion transmembrane transporter activity13
GO:0051496positive regulation of stress fiber assembly238
GO:0000723telomere maintenance656
GO:0006739NADP metabolic process16
GO:0006268DNA unwinding involved in DNA replication110
GO:0031402sodium ion binding13
GO:0042162telomeric DNA binding111
GO:0034113heterotypic cell-cell adhesion119
GO:0009898cytoplasmic side of plasma membrane141
GO:2001238positive regulation of extrinsic apoptotic signaling pathway227
GO:0002931response to ischemia120
GO:0000793condensed chromosome121
GO:0006457protein folding7143
GO:0008299isoprenoid biosynthetic process111
GO:0003729mRNA binding372
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding7165
GO:0045088regulation of innate immune response113
GO:0032461positive regulation of protein oligomerization112
GO:0004622lysophospholipase activity111
GO:0009314response to radiation127
GO:0070245positive regulation of thymocyte apoptotic process15
GO:0001833inner cell mass cell proliferation113
GO:0045596negative regulation of cell differentiation120
GO:0006412translation20230
GO:0009303rRNA transcription111
GO:0019322pentose biosynthetic process22
GO:0004222metalloendopeptidase activity177
GO:0030178negative regulation of Wnt signaling pathway235
GO:0030521androgen receptor signaling pathway141
GO:0030135coated vesicle13
GO:0006633fatty acid biosynthetic process332
GO:0030308negative regulation of cell growth6110
GO:0043034costamere120
GO:0005664nuclear origin of replication recognition complex18
GO:0045214sarcomere organization126
GO:0030030cell projection organization126
GO:0007613memory153
GO:0031492nucleosomal DNA binding427
GO:0031994insulin-like growth factor I binding17
GO:0034329cell junction assembly168
GO:0005874microtubule7249
GO:0031340positive regulation of vesicle fusion17
GO:0019068virion assembly117
GO:0032411positive regulation of transporter activity15
GO:0001973adenosine receptor signaling pathway19
GO:0043621protein self-association236
GO:0015949nucleobase-containing small molecule interconversion118
GO:0042734presynaptic membrane149
GO:0016887ATPase activity7140
GO:0019209kinase activator activity16
GO:0090004positive regulation of establishment of protein localization to plasma membrane122
GO:0022624proteasome accessory complex817
GO:0021895cerebral cortex neuron differentiation19
GO:0006816calcium ion transport272
GO:0006695cholesterol biosynthetic process434
GO:0019827stem cell maintenance147
GO:0003684damaged DNA binding749
GO:0012505endomembrane system256
GO:0048593camera-type eye morphogenesis116
GO:0006631fatty acid metabolic process140
GO:0002102podosome216
GO:0016074snoRNA metabolic process11
GO:0002093auditory receptor cell morphogenesis12
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling130
GO:0004252serine-type endopeptidase activity1106
GO:0060664epithelial cell proliferation involved in salivary gland morphogenesis17
GO:0046827positive regulation of protein export from nucleus313
GO:0010212response to ionizing radiation142
GO:0040020regulation of meiosis16
GO:0000125PCAF complex16
GO:0043198dendritic shaft129
GO:0009948anterior/posterior axis specification214
GO:0008233peptidase activity254
GO:0034683integrin alphav-beta3 complex12
GO:0004672protein kinase activity6177
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway443
GO:0042273ribosomal large subunit biogenesis413
GO:0033189response to vitamin A114
GO:0007097nuclear migration16
GO:0006386termination of RNA polymerase III transcription318
GO:0051414response to cortisol15
GO:0048146positive regulation of fibroblast proliferation244
GO:0043024ribosomal small subunit binding19
GO:0045599negative regulation of fat cell differentiation235
GO:0004691cAMP-dependent protein kinase activity17
GO:0045792negative regulation of cell size19
GO:0005978glycogen biosynthetic process126
GO:0006098pentose-phosphate shunt410
GO:0007422peripheral nervous system development125
GO:0031465Cul4B-RING E3 ubiquitin ligase complex35
GO:0001954positive regulation of cell-matrix adhesion121
GO:0000791euchromatin16
GO:0005245voltage-gated calcium channel activity132
GO:0050560aspartate-tRNA(Asn) ligase activity11
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)14
GO:0071374cellular response to parathyroid hormone stimulus14
GO:0048699generation of neurons19
GO:0030496midbody5108
GO:0030337DNA polymerase processivity factor activity12
GO:0019897extrinsic component of plasma membrane220
GO:0015631tubulin binding127
GO:0019932second-messenger-mediated signaling15
GO:0006084acetyl-CoA metabolic process13
GO:0008144drug binding163
GO:0016780phosphotransferase activity, for other substituted phosphate groups12
GO:0043086negative regulation of catalytic activity272
GO:0005886plasma membrane452582
GO:0016461unconventional myosin complex17
GO:0050776regulation of immune response176
GO:0000226microtubule cytoskeleton organization352
GO:0097153cysteine-type endopeptidase activity involved in apoptotic process14
GO:0014823response to activity131
GO:0042147retrograde transport, endosome to Golgi341
GO:0050046lathosterol oxidase activity11
GO:0009048dosage compensation by inactivation of X chromosome13
GO:0071480cellular response to gamma radiation113
GO:0005902microvillus238
GO:0006306DNA methylation122
GO:0045665negative regulation of neuron differentiation244
GO:0090307spindle assembly involved in mitosis110
GO:0005509calcium ion binding5531
GO:0035145exon-exon junction complex119
GO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 production14
GO:0002755MyD88-dependent toll-like receptor signaling pathway380
GO:0086013membrane repolarization during cardiac muscle cell action potential17
GO:0016324apical plasma membrane5199
GO:0043407negative regulation of MAP kinase activity232
GO:0097190apoptotic signaling pathway6113
GO:0001819positive regulation of cytokine production117
GO:0030864cortical actin cytoskeleton123
GO:0051968positive regulation of synaptic transmission, glutamatergic116
GO:0032051clathrin light chain binding14
GO:0032320positive regulation of Ras GTPase activity232
GO:0006614SRP-dependent cotranslational protein targeting to membrane10104
GO:2000378negative regulation of reactive oxygen species metabolic process114
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand215
GO:0036462TRAIL-activated apoptotic signaling pathway13
GO:00063707-methylguanosine mRNA capping530
GO:0030100regulation of endocytosis118
GO:0045104intermediate filament cytoskeleton organization113
GO:0006403RNA localization12
GO:0051924regulation of calcium ion transport122
GO:0007584response to nutrient471
GO:0060154cellular process regulating host cell cycle in response to virus13
GO:0015269calcium-activated potassium channel activity19
GO:0060559positive regulation of calcidiol 1-monooxygenase activity13
GO:0043219lateral loop15
GO:0007520myoblast fusion116
GO:0048863stem cell differentiation119
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process275
GO:0006892post-Golgi vesicle-mediated transport343
GO:0034236protein kinase A catalytic subunit binding112
GO:0003148outflow tract septum morphogenesis114
GO:0005665DNA-directed RNA polymerase II, core complex416
GO:0045109intermediate filament organization111
GO:0006361transcription initiation from RNA polymerase I promoter326
GO:0015643toxic substance binding19
GO:0010569regulation of double-strand break repair via homologous recombination110
GO:0003743translation initiation factor activity849
GO:0005913cell-cell adherens junction129
GO:0001837epithelial to mesenchymal transition133
GO:0043249erythrocyte maturation111
GO:0016580Sin3 complex112
GO:0060744mammary gland branching involved in thelarche16
GO:0006915apoptotic process33555
GO:0035091phosphatidylinositol binding361
GO:0032139dinucleotide insertion or deletion binding13
GO:0048469cell maturation138
GO:0060070canonical Wnt signaling pathway375
GO:0000463maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)13
GO:0035794positive regulation of mitochondrial membrane permeability13
GO:0031571mitotic G1 DNA damage checkpoint411
GO:0032007negative regulation of TOR signaling120
GO:0048675axon extension121
GO:0014065phosphatidylinositol 3-kinase signaling221
GO:0043043peptide biosynthetic process15
GO:0009636response to toxic substance365
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding244
GO:0035066positive regulation of histone acetylation115
GO:0070688MLL5-L complex18
GO:0045989positive regulation of striated muscle contraction11
GO:0032927positive regulation of activin receptor signaling pathway16
GO:0008088axon cargo transport19
GO:0000972transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery11
GO:0006438valyl-tRNA aminoacylation12
GO:0042383sarcolemma371
GO:0090200positive regulation of release of cytochrome c from mitochondria122
GO:0050715positive regulation of cytokine secretion122
GO:0071805potassium ion transmembrane transport183
GO:0032722positive regulation of chemokine production116
GO:0010595positive regulation of endothelial cell migration138
GO:0070335aspartate binding11
GO:0010332response to gamma radiation328
GO:0004713protein tyrosine kinase activity582
GO:0006768biotin metabolic process19
GO:0051721protein phosphatase 2A binding117
GO:0071565nBAF complex312
GO:0071899negative regulation of estrogen receptor binding13
GO:0072583clathrin-mediated endocytosis212
GO:0045760positive regulation of action potential17
GO:0005546phosphatidylinositol-4,5-bisphosphate binding239
GO:0030010establishment of cell polarity221
GO:0046294formaldehyde catabolic process22
GO:0008494translation activator activity19
GO:0004767sphingomyelin phosphodiesterase activity16
GO:0019221cytokine-mediated signaling pathway9221
GO:0048566embryonic digestive tract development214
GO:0005635nuclear envelope6113
GO:0007602phototransduction117
GO:0006987activation of signaling protein activity involved in unfolded protein response361
GO:0045095keratin filament137
GO:0006281DNA repair18261
GO:0050852T cell receptor signaling pathway485
GO:0001669acrosomal vesicle149
GO:0031023microtubule organizing center organization15
GO:0060081membrane hyperpolarization112
GO:0038095Fc-epsilon receptor signaling pathway12168
GO:0034504protein localization to nucleus228
GO:0071526semaphorin-plexin signaling pathway119
GO:0097371MDM2/MDM4 family protein binding15
GO:0072300positive regulation of metanephric glomerulus development13
GO:0045777positive regulation of blood pressure117
GO:0031625ubiquitin protein ligase binding14178
GO:0016773phosphotransferase activity, alcohol group as acceptor15
GO:0005850eukaryotic translation initiation factor 2 complex13
GO:0004971alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity14
GO:0090403oxidative stress-induced premature senescence14
GO:0004826phenylalanine-tRNA ligase activity14
GO:0034696response to prostaglandin F12
GO:0060263regulation of respiratory burst14
GO:0060694regulation of cholesterol transporter activity11
GO:0015031protein transport5341
GO:0008285negative regulation of cell proliferation11353
GO:0043626PCNA complex11
GO:0016024CDP-diacylglycerol biosynthetic process110
GO:0003899DNA-directed RNA polymerase activity325
GO:0033490cholesterol biosynthetic process via lathosterol11
GO:0060715syncytiotrophoblast cell differentiation involved in labyrinthine layer development13
GO:2001271negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis13
GO:2000810regulation of tight junction assembly29
GO:0001707mesoderm formation125
GO:0004046aminoacylase activity14
GO:0030672synaptic vesicle membrane140
GO:0006206pyrimidine nucleobase metabolic process222
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion119
GO:0016230sphingomyelin phosphodiesterase activator activity12
GO:0045840positive regulation of mitosis228
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway135
GO:0051903S-(hydroxymethyl)glutathione dehydrogenase activity11
GO:0007569cell aging125
GO:0030837negative regulation of actin filament polymerization19
GO:0071677positive regulation of mononuclear cell migration13
GO:0043234protein complex18295
GO:0032633interleukin-4 production12
GO:0001832blastocyst growth13
GO:0071312cellular response to alkaloid17
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation375
GO:0006338chromatin remodeling566
GO:0097191extrinsic apoptotic signaling pathway338
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription3147
GO:0004142diacylglycerol cholinephosphotransferase activity13
GO:0070314G1 to G0 transition13
GO:0045604regulation of epidermal cell differentiation13
GO:0060326cell chemotaxis250
GO:0005095GTPase inhibitor activity113
GO:0008207C21-steroid hormone metabolic process11
GO:0006309apoptotic DNA fragmentation117
GO:0090136epithelial cell-cell adhesion19
GO:0007565female pregnancy178
GO:0031529ruffle organization115
GO:0000056ribosomal small subunit export from nucleus13
GO:0044354macropinosome13
GO:0072278metanephric comma-shaped body morphogenesis13
GO:0033152immunoglobulin V(D)J recombination13
GO:0007093mitotic cell cycle checkpoint231
GO:0030132clathrin coat of coated pit27
GO:1901030positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway18
GO:0030139endocytic vesicle144
GO:0006898receptor-mediated endocytosis384
GO:0007010cytoskeleton organization191
GO:0034199activation of protein kinase A activity115
GO:0055093response to hyperoxia113
GO:0003678DNA helicase activity317
GO:0051209release of sequestered calcium ion into cytosol126
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand234
GO:0019677NAD catabolic process11
GO:0006543glutamine catabolic process14
GO:0030742GTP-dependent protein binding117
GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process154
GO:0004822isoleucine-tRNA ligase activity12
GO:0030007cellular potassium ion homeostasis29
GO:0030334regulation of cell migration250
GO:0004512inositol-3-phosphate synthase activity11
GO:0007017microtubule-based process327
GO:0030165PDZ domain binding194
GO:0055085transmembrane transport10435
GO:0030182neuron differentiation176
GO:0090179planar cell polarity pathway involved in neural tube closure113
GO:0003382epithelial cell morphogenesis19
GO:0036149phosphatidylinositol acyl-chain remodeling111
GO:0002862negative regulation of inflammatory response to antigenic stimulus16
GO:0004853uroporphyrinogen decarboxylase activity11
GO:0045080positive regulation of chemokine biosynthetic process19
GO:0033600negative regulation of mammary gland epithelial cell proliferation15
GO:0006290pyrimidine dimer repair14
GO:2000425regulation of apoptotic cell clearance11
GO:0034452dynactin binding16
GO:0016597amino acid binding119
GO:2000564regulation of CD8-positive, alpha-beta T cell proliferation11
GO:0001675acrosome assembly110
GO:0043197dendritic spine382
GO:0017137Rab GTPase binding276
GO:0000186activation of MAPKK activity154
GO:0035799ureter maturation14
GO:0006813potassium ion transport165
GO:0010970microtubule-based transport11
GO:0001227RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription119
GO:0007084mitotic nuclear envelope reassembly110
GO:0071300cellular response to retinoic acid255
GO:0004151dihydroorotase activity11
GO:00061032-oxoglutarate metabolic process116
GO:0045429positive regulation of nitric oxide biosynthetic process335
GO:0007167enzyme linked receptor protein signaling pathway19
GO:0005212structural constituent of eye lens116
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator220
GO:0005484SNAP receptor activity224
GO:0019834phospholipase A2 inhibitor activity14
GO:0032864activation of Cdc42 GTPase activity14
GO:0005770late endosome193
GO:0097199cysteine-type endopeptidase activity involved in apoptotic signaling pathway12
GO:0005234extracellular-glutamate-gated ion channel activity118
GO:0045713low-density lipoprotein particle receptor biosynthetic process11
GO:0042391regulation of membrane potential150
GO:0006415translational termination1087
GO:0000054ribosomal subunit export from nucleus11
GO:0001104RNA polymerase II transcription cofactor activity133
GO:0051258protein polymerization227
GO:0006469negative regulation of protein kinase activity465
GO:0034399nuclear periphery112
GO:0004601peroxidase activity119
GO:0050680negative regulation of epithelial cell proliferation151
GO:0050321tau-protein kinase activity112
GO:0021799cerebral cortex radially oriented cell migration27
GO:0005938cell cortex3104
GO:0030877beta-catenin destruction complex110
GO:0008344adult locomotory behavior144
GO:0000060protein import into nucleus, translocation524
GO:0030669clathrin-coated endocytic vesicle membrane428
GO:0097178ruffle assembly16
GO:0017053transcriptional repressor complex251
GO:0016602CCAAT-binding factor complex14
GO:00515394 iron, 4 sulfur cluster binding335
GO:0036151phosphatidylcholine acyl-chain remodeling118
GO:0030506ankyrin binding120
GO:0031663lipopolysaccharide-mediated signaling pathway229
GO:0005955calcineurin complex24
GO:0004869cysteine-type endopeptidase inhibitor activity123
GO:0007127meiosis I12
GO:0051775response to redox state110
GO:0005884actin filament244
GO:0007281germ cell development128
GO:0060850regulation of transcription involved in cell fate commitment15
GO:0071439clathrin complex23
GO:0006501C-terminal protein lipidation226
GO:0019050suppression by virus of host apoptotic process12
GO:0047676arachidonate-CoA ligase activity11
GO:0004930G-protein coupled receptor activity1127
GO:0051701interaction with host432
GO:0035372protein localization to microtubule18
GO:0005876spindle microtubule234
GO:0072277metanephric glomerular capillary formation13
GO:0070409carbamoyl phosphate biosynthetic process12
GO:0006968cellular defense response154
GO:0003084positive regulation of systemic arterial blood pressure17
GO:0032025response to cobalt ion15
GO:0001732formation of cytoplasmic translation initiation complex14
GO:0045732positive regulation of protein catabolic process350
GO:0005794Golgi apparatus15610
GO:0030532small nuclear ribonucleoprotein complex118
GO:0060347heart trabecula formation114
GO:0030285integral component of synaptic vesicle membrane14
GO:0046469platelet activating factor metabolic process11