int-snw-51477

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.934	1.79e-15	2.53e-03	4.07e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-51477 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACO2	50	50	1.000	1.076	191	Yes	-
EIF2S2	8894	27	1.075	1.138	81	Yes	-
EEF2	1938	27	0.890	1.043	301	Yes	-
PSMD3	5709	57	0.986	1.106	146	Yes	-
CLTC	1213	35	0.884	1.138	247	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
[ ISYNA1 ]	51477	1	-0.120	0.934	48	-	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (15)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CLTC	1213	ISYNA1	51477	pp	--	int.I2D: BioGrid_Yeast, MINT_Yeast, Tarassov_PCA, IntAct_Yeast
CLTC	1213	EIF2S2	8894	pp	--	int.I2D: YeastLow
PSMD3	5709	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
EEF2	1938	PGD	5226	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
EEF2	1938	ISYNA1	51477	pp	--	int.I2D: BioGrid_Yeast, MINT_Yeast, Tarassov_PCA, IntAct_Yeast
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
ACO2	50	PSMD11	5717	pp	--	int.I2D: YeastLow
ACTB	60	EEF2	1938	pp	--	int.I2D: YeastLow, IntAct_Yeast
PGD	5226	PSMD3	5709	pp	--	int.I2D: YeastLow
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow
ACTB	60	CLTC	1213	pp	--	int.I2D: IntAct_Yeast
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
EEF2	1938	PSMD3	5709	pp	--	int.I2D: Krogan_NonCore
ACO2	50	ISYNA1	51477	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (144)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005829	cytosol	6.07e-06	8.76e-02	2.361	8	132	2496
GO:0005838	proteasome regulatory particle	2.28e-05	3.28e-01	8.061	2	7	12
GO:0022624	proteasome accessory complex	4.68e-05	6.76e-01	7.559	2	8	17
GO:0044281	small molecule metabolic process	3.91e-04	1.00e+00	2.726	5	58	1211
GO:0006521	regulation of cellular amino acid metabolic process	4.17e-04	1.00e+00	6.002	2	17	50
GO:0010467	gene expression	4.79e-04	1.00e+00	3.260	4	59	669
GO:0000502	proteasome complex	5.62e-04	1.00e+00	5.788	2	17	58
GO:0004512	inositol-3-phosphate synthase activity	6.24e-04	1.00e+00	10.646	1	1	1
GO:0019521	D-gluconate metabolic process	6.24e-04	1.00e+00	10.646	1	1	1
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	6.84e-04	1.00e+00	5.646	2	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.05e-04	1.00e+00	5.624	2	22	65
GO:0019901	protein kinase binding	8.01e-04	1.00e+00	3.923	3	21	317
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	8.18e-04	1.00e+00	5.517	2	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	8.65e-04	1.00e+00	5.476	2	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	9.13e-04	1.00e+00	5.437	2	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	9.38e-04	1.00e+00	5.417	2	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.04e-03	1.00e+00	5.342	2	23	79
GO:0070062	extracellular vesicular exosome	1.12e-03	1.00e+00	2.002	6	104	2400
GO:0051538	3 iron, 4 sulfur cluster binding	1.25e-03	1.00e+00	9.646	1	1	2
GO:0002176	male germ cell proliferation	1.25e-03	1.00e+00	9.646	1	1	2
GO:0019322	pentose biosynthetic process	1.25e-03	1.00e+00	9.646	1	2	2
GO:0003994	aconitate hydratase activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.41e-03	1.00e+00	5.123	2	21	92
GO:0016020	membrane	1.80e-03	1.00e+00	2.253	5	90	1681
GO:0005850	eukaryotic translation initiation factor 2 complex	1.87e-03	1.00e+00	9.061	1	1	3
GO:1900126	negative regulation of hyaluronan biosynthetic process	1.87e-03	1.00e+00	9.061	1	2	3
GO:0006021	inositol biosynthetic process	1.87e-03	1.00e+00	9.061	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	1.87e-03	1.00e+00	9.061	1	2	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	1.87e-03	1.00e+00	9.061	1	1	3
GO:0071439	clathrin complex	1.87e-03	1.00e+00	9.061	1	2	3
GO:0030529	ribonucleoprotein complex	2.08e-03	1.00e+00	4.839	2	8	112
GO:0000209	protein polyubiquitination	2.23e-03	1.00e+00	4.788	2	20	116
GO:0032051	clathrin light chain binding	2.49e-03	1.00e+00	8.646	1	1	4
GO:1903077	negative regulation of protein localization to plasma membrane	2.49e-03	1.00e+00	8.646	1	1	4
GO:0044267	cellular protein metabolic process	2.56e-03	1.00e+00	3.342	3	29	474
GO:0043248	proteasome assembly	3.12e-03	1.00e+00	8.324	1	1	5
GO:0006102	isocitrate metabolic process	3.12e-03	1.00e+00	8.324	1	1	5
GO:0061024	membrane organization	3.45e-03	1.00e+00	4.466	2	7	145
GO:0000082	G1/S transition of mitotic cell cycle	3.64e-03	1.00e+00	4.427	2	32	149
GO:0042981	regulation of apoptotic process	3.69e-03	1.00e+00	4.417	2	24	150
GO:0030130	clathrin coat of trans-Golgi network vesicle	3.74e-03	1.00e+00	8.061	1	3	6
GO:0030957	Tat protein binding	3.74e-03	1.00e+00	8.061	1	3	6
GO:0006101	citrate metabolic process	3.74e-03	1.00e+00	8.061	1	1	6
GO:0030118	clathrin coat	3.74e-03	1.00e+00	8.061	1	2	6
GO:0030132	clathrin coat of coated pit	4.36e-03	1.00e+00	7.839	1	2	7
GO:0034641	cellular nitrogen compound metabolic process	4.76e-03	1.00e+00	4.228	2	20	171
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0008494	translation activator activity	5.60e-03	1.00e+00	7.476	1	1	9
GO:0006098	pentose-phosphate shunt	6.22e-03	1.00e+00	7.324	1	4	10
GO:0016071	mRNA metabolic process	7.98e-03	1.00e+00	3.845	2	31	223
GO:0008654	phospholipid biosynthetic process	8.09e-03	1.00e+00	6.946	1	1	13
GO:0030234	enzyme regulator activity	8.09e-03	1.00e+00	6.946	1	3	13
GO:0006412	translation	8.47e-03	1.00e+00	3.801	2	20	230
GO:0035267	NuA4 histone acetyltransferase complex	8.70e-03	1.00e+00	6.839	1	4	14
GO:0016070	RNA metabolic process	9.71e-03	1.00e+00	3.698	2	32	247
GO:0050998	nitric-oxide synthase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0042176	regulation of protein catabolic process	9.94e-03	1.00e+00	6.646	1	3	16
GO:0003746	translation elongation factor activity	1.06e-02	1.00e+00	6.559	1	3	17
GO:0048863	stem cell differentiation	1.18e-02	1.00e+00	6.398	1	1	19
GO:0030863	cortical cytoskeleton	1.36e-02	1.00e+00	6.187	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	4	22
GO:0043234	protein complex	1.37e-02	1.00e+00	3.442	2	18	295
GO:0043044	ATP-dependent chromatin remodeling	1.43e-02	1.00e+00	6.123	1	4	23
GO:0005844	polysome	1.43e-02	1.00e+00	6.123	1	4	23
GO:0008135	translation factor activity, nucleic acid binding	1.49e-02	1.00e+00	6.061	1	7	24
GO:0050661	NADP binding	1.67e-02	1.00e+00	5.891	1	2	27
GO:0031492	nucleosomal DNA binding	1.67e-02	1.00e+00	5.891	1	4	27
GO:0006099	tricarboxylic acid cycle	1.73e-02	1.00e+00	5.839	1	4	28
GO:0030669	clathrin-coated endocytic vesicle membrane	1.73e-02	1.00e+00	5.839	1	4	28
GO:0019894	kinesin binding	1.73e-02	1.00e+00	5.839	1	1	28
GO:0033572	transferrin transport	1.86e-02	1.00e+00	5.739	1	5	30
GO:0031623	receptor internalization	1.92e-02	1.00e+00	5.692	1	2	31
GO:0005925	focal adhesion	2.05e-02	1.00e+00	3.130	2	19	366
GO:0032588	trans-Golgi network membrane	2.10e-02	1.00e+00	5.559	1	2	34
GO:0001895	retina homeostasis	2.10e-02	1.00e+00	5.559	1	1	34
GO:0051539	4 iron, 4 sulfur cluster binding	2.16e-02	1.00e+00	5.517	1	3	35
GO:0034332	adherens junction organization	2.22e-02	1.00e+00	5.476	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.29e-02	1.00e+00	5.437	1	4	37
GO:0000278	mitotic cell cycle	2.33e-02	1.00e+00	3.035	2	48	391
GO:0044822	poly(A) RNA binding	2.35e-02	1.00e+00	2.187	3	49	1056
GO:0070527	platelet aggregation	2.35e-02	1.00e+00	5.398	1	2	38
GO:0043647	inositol phosphate metabolic process	2.41e-02	1.00e+00	5.361	1	1	39
GO:0005654	nucleoplasm	2.51e-02	1.00e+00	2.152	3	76	1082
GO:0030136	clathrin-coated vesicle	2.59e-02	1.00e+00	5.254	1	4	42
GO:0006892	post-Golgi vesicle-mediated transport	2.65e-02	1.00e+00	5.220	1	3	43
GO:0021762	substantia nigra development	2.71e-02	1.00e+00	5.187	1	2	44
GO:0045727	positive regulation of translation	2.71e-02	1.00e+00	5.187	1	3	44
GO:0043066	negative regulation of apoptotic process	2.71e-02	1.00e+00	2.918	2	31	424
GO:0003743	translation initiation factor activity	3.02e-02	1.00e+00	5.031	1	8	49
GO:0006091	generation of precursor metabolites and energy	3.08e-02	1.00e+00	5.002	1	3	50
GO:0003725	double-stranded RNA binding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.26e-02	1.00e+00	4.918	1	5	53
GO:0002244	hematopoietic progenitor cell differentiation	3.32e-02	1.00e+00	4.891	1	1	54
GO:0045216	cell-cell junction organization	3.32e-02	1.00e+00	4.891	1	2	54
GO:0016032	viral process	4.14e-02	1.00e+00	2.585	2	55	534
GO:0034329	cell junction assembly	4.17e-02	1.00e+00	4.559	1	1	68
GO:0006915	apoptotic process	4.45e-02	1.00e+00	2.530	2	33	555
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.53e-02	1.00e+00	4.437	1	6	74
GO:0008584	male gonad development	4.59e-02	1.00e+00	4.417	1	3	75
GO:0006898	receptor-mediated endocytosis	5.12e-02	1.00e+00	4.254	1	3	84
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	5.48e-02	1.00e+00	4.154	1	7	90
GO:0042470	melanosome	5.54e-02	1.00e+00	4.138	1	9	91
GO:0006928	cellular component movement	5.54e-02	1.00e+00	4.138	1	7	91
GO:0005200	structural constituent of cytoskeleton	5.54e-02	1.00e+00	4.138	1	8	91
GO:0001649	osteoblast differentiation	5.60e-02	1.00e+00	4.123	1	6	92
GO:0006414	translational elongation	5.66e-02	1.00e+00	4.107	1	13	93
GO:0014069	postsynaptic density	6.37e-02	1.00e+00	3.932	1	3	105
GO:0005506	iron ion binding	6.37e-02	1.00e+00	3.932	1	4	105
GO:0072562	blood microparticle	6.72e-02	1.00e+00	3.852	1	3	111
GO:0005819	spindle	6.78e-02	1.00e+00	3.839	1	7	112
GO:0044237	cellular metabolic process	7.07e-02	1.00e+00	3.776	1	5	117
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	5	118
GO:0006511	ubiquitin-dependent protein catabolic process	7.60e-02	1.00e+00	3.669	1	5	126
GO:0000790	nuclear chromatin	7.77e-02	1.00e+00	3.635	1	9	129
GO:0006413	translational initiation	7.89e-02	1.00e+00	3.613	1	17	131
GO:0031982	vesicle	7.89e-02	1.00e+00	3.613	1	9	131
GO:0006457	protein folding	8.58e-02	1.00e+00	3.486	1	7	143
GO:0010628	positive regulation of gene expression	8.75e-02	1.00e+00	3.456	1	5	146
GO:0005198	structural molecule activity	8.98e-02	1.00e+00	3.417	1	5	150
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	9.84e-02	1.00e+00	3.280	1	7	165
GO:0030424	axon	9.90e-02	1.00e+00	3.271	1	4	166
GO:0006886	intracellular protein transport	1.02e-01	1.00e+00	3.228	1	5	171
GO:0003924	GTPase activity	1.16e-01	1.00e+00	3.024	1	12	197
GO:0001701	in utero embryonic development	1.19e-01	1.00e+00	2.995	1	8	201
GO:0005634	nucleus	1.20e-01	1.00e+00	0.814	5	136	4559
GO:0006184	GTP catabolic process	1.26e-01	1.00e+00	2.905	1	12	214
GO:0007067	mitotic nuclear division	1.33e-01	1.00e+00	2.820	1	14	227
GO:0005759	mitochondrial matrix	1.34e-01	1.00e+00	2.813	1	14	228
GO:0005975	carbohydrate metabolic process	1.47e-01	1.00e+00	2.663	1	9	253
GO:0005856	cytoskeleton	1.68e-01	1.00e+00	2.461	1	12	291
GO:0005525	GTP binding	1.78e-01	1.00e+00	2.370	1	12	310
GO:0007411	axon guidance	1.82e-01	1.00e+00	2.329	1	13	319
GO:0003723	RNA binding	1.94e-01	1.00e+00	2.228	1	20	342
GO:0055114	oxidation-reduction process	2.34e-01	1.00e+00	1.932	1	12	420
GO:0007596	blood coagulation	2.51e-01	1.00e+00	1.816	1	18	455
GO:0005515	protein binding	3.04e-01	1.00e+00	0.412	5	184	6024
GO:0045087	innate immune response	3.16e-01	1.00e+00	1.427	1	24	596
GO:0005615	extracellular space	4.61e-01	1.00e+00	0.744	1	17	957
GO:0005739	mitochondrion	4.76e-01	1.00e+00	0.683	1	28	998
GO:0005524	ATP binding	5.72e-01	1.00e+00	0.304	1	60	1298
GO:0046872	metal ion binding	5.75e-01	1.00e+00	0.294	1	25	1307
GO:0005730	nucleolus	6.63e-01	1.00e+00	-0.034	1	69	1641
GO:0005737	cytoplasm	7.26e-01	1.00e+00	-0.233	2	110	3767
GO:0005886	plasma membrane	8.31e-01	1.00e+00	-0.688	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-51477

Statistics

Genes (9)

Interactions (15)

Related GO terms (144)