Related GO terms (2191)

Accession number Name Occurrences in all snw genes Occurrences in all int/reg genes
GO:0009897external side of plasma membrane4183
GO:0000381regulation of alternative mRNA splicing, via spliceosome229
GO:0043353enucleate erythrocyte differentiation16
GO:0044237cellular metabolic process3118
GO:0005769early endosome2158
GO:0001558regulation of cell growth466
GO:0009263deoxyribonucleotide biosynthetic process13
GO:0008092cytoskeletal protein binding148
GO:0007286spermatid development144
GO:0008360regulation of cell shape1106
GO:0004003ATP-dependent DNA helicase activity327
GO:0030101natural killer cell activation116
GO:0008094DNA-dependent ATPase activity134
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation15
GO:0046718viral entry into host cell118
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen19
GO:0005663DNA replication factor C complex16
GO:0097202activation of cysteine-type endopeptidase activity18
GO:0051054positive regulation of DNA metabolic process12
GO:0030168platelet activation9205
GO:0003725double-stranded RNA binding654
GO:0043508negative regulation of JUN kinase activity113
GO:0033209tumor necrosis factor-mediated signaling pathway128
GO:0006272leading strand elongation22
GO:0051092positive regulation of NF-kappaB transcription factor activity4125
GO:0003680AT DNA binding18
GO:0042921glucocorticoid receptor signaling pathway17
GO:0043204perikaryon162
GO:0045171intercellular bridge231
GO:0016601Rac protein signal transduction117
GO:0060071Wnt signaling pathway, planar cell polarity pathway211
GO:0045252oxoglutarate dehydrogenase complex22
GO:0032781positive regulation of ATPase activity125
GO:2001239regulation of extrinsic apoptotic signaling pathway in absence of ligand111
GO:0072070loop of Henle development12
GO:0030316osteoclast differentiation222
GO:0001940male pronucleus15
GO:1903416response to glycoside13
GO:0008234cysteine-type peptidase activity237
GO:0070628proteasome binding110
GO:0050840extracellular matrix binding119
GO:0030705cytoskeleton-dependent intracellular transport114
GO:0001102RNA polymerase II activating transcription factor binding437
GO:0045892negative regulation of transcription, DNA-templated14424
GO:0071229cellular response to acid chemical15
GO:0008017microtubule binding7150
GO:0042100B cell proliferation125
GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity13
GO:0030902hindbrain development116
GO:0004305ethanolamine kinase activity14
GO:0051084'de novo' posttranslational protein folding437
GO:0008309double-stranded DNA exodeoxyribonuclease activity11
GO:0033276transcription factor TFTC complex114
GO:0010977negative regulation of neuron projection development230
GO:0008283cell proliferation12331
GO:0031122cytoplasmic microtubule organization218
GO:0097021lymphocyte migration into lymphoid organs12
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage249
GO:0030336negative regulation of cell migration183
GO:0005672transcription factor TFIIA complex15
GO:0001947heart looping149
GO:0035102PRC1 complex112
GO:0034686integrin alphav-beta8 complex12
GO:0021702cerebellar Purkinje cell differentiation112
GO:0008301DNA binding, bending117
GO:0008284positive regulation of cell proliferation8392
GO:0034314Arp2/3 complex-mediated actin nucleation111
GO:0045747positive regulation of Notch signaling pathway123
GO:0034134toll-like receptor 2 signaling pathway173
GO:0030301cholesterol transport114
GO:0043627response to estrogen257
GO:0006612protein targeting to membrane118
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay10114
GO:0045944positive regulation of transcription from RNA polymerase II promoter19811
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules1104
GO:0034186apolipoprotein A-I binding13
GO:0051402neuron apoptotic process236
GO:0031011Ino80 complex314
GO:0055114oxidation-reduction process11481
GO:0032703negative regulation of interleukin-2 production110
GO:0034162toll-like receptor 9 signaling pathway172
GO:0007229integrin-mediated signaling pathway278
GO:0003712transcription cofactor activity144
GO:0007623circadian rhythm154
GO:0032407MutSalpha complex binding15
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity13
GO:0006407rRNA export from nucleus12
GO:0045111intermediate filament cytoskeleton149
GO:0005882intermediate filament166
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity11
GO:0046688response to copper ion113
GO:0045608negative regulation of auditory receptor cell differentiation12
GO:0043966histone H3 acetylation245
GO:0034602oxoglutarate dehydrogenase (NAD+) activity11
GO:0035035histone acetyltransferase binding119
GO:0000052citrulline metabolic process14
GO:0005847mRNA cleavage and polyadenylation specificity factor complex19
GO:0048714positive regulation of oligodendrocyte differentiation211
GO:0031982vesicle10134
GO:0003697single-stranded DNA binding969
GO:0097193intrinsic apoptotic signaling pathway455
GO:0034116positive regulation of heterotypic cell-cell adhesion19
GO:0005125cytokine activity1146
GO:0030154cell differentiation5325
GO:0000398mRNA splicing, via spliceosome12165
GO:0031936negative regulation of chromatin silencing12
GO:0043066negative regulation of apoptotic process30433
GO:0004004ATP-dependent RNA helicase activity218
GO:0042824MHC class I peptide loading complex12
GO:0010888negative regulation of lipid storage27
GO:0031415NatA complex15
GO:0051117ATPase binding141
GO:0043008ATP-dependent protein binding17
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2394
GO:0071813lipoprotein particle binding15
GO:0045907positive regulation of vasoconstriction123
GO:0010634positive regulation of epithelial cell migration124
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening125
GO:0030225macrophage differentiation115
GO:1902167positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator12
GO:0072014proximal tubule development13
GO:0001836release of cytochrome c from mitochondria224
GO:0046325negative regulation of glucose import18
GO:0031428box C/D snoRNP complex14
GO:2000466negative regulation of glycogen (starch) synthase activity13
GO:0042594response to starvation132
GO:0019904protein domain specific binding6181
GO:0006836neurotransmitter transport122
GO:0019899enzyme binding11288
GO:0001649osteoblast differentiation695
GO:0006360transcription from RNA polymerase I promoter430
GO:0043243positive regulation of protein complex disassembly13
GO:0048012hepatocyte growth factor receptor signaling pathway16
GO:0048487beta-tubulin binding130
GO:0006068ethanol catabolic process14
GO:0030041actin filament polymerization322
GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)15
GO:0005654nucleoplasm831095
GO:0006458'de novo' protein folding13
GO:0016208AMP binding19
GO:0047498calcium-dependent phospholipase A2 activity18
GO:0007507heart development5141
GO:0031902late endosome membrane180
GO:0061048negative regulation of branching involved in lung morphogenesis11
GO:0043531ADP binding128
GO:0030055cell-substrate junction11
GO:0043029T cell homeostasis122
GO:0018105peptidyl-serine phosphorylation169
GO:0032387negative regulation of intracellular transport14
GO:0033365protein localization to organelle117
GO:0007220Notch receptor processing122
GO:0043141ATP-dependent 5'-3' DNA helicase activity14
GO:0006391transcription initiation from mitochondrial promoter13
GO:0000776kinetochore463
GO:1990077primosome complex12
GO:0030032lamellipodium assembly231
GO:0000922spindle pole491
GO:0014070response to organic cyclic compound343
GO:0045986negative regulation of smooth muscle contraction15
GO:0006269DNA replication, synthesis of RNA primer25
GO:0007088regulation of mitosis119
GO:1990430extracellular matrix protein binding12
GO:0046329negative regulation of JNK cascade124
GO:0030183B cell differentiation159
GO:0019789SUMO ligase activity111
GO:0060699regulation of endoribonuclease activity11
GO:0071013catalytic step 2 spliceosome779
GO:0071230cellular response to amino acid stimulus242
GO:0045765regulation of angiogenesis124
GO:0021695cerebellar cortex development16
GO:0051301cell division681
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process2579
GO:0030529ribonucleoprotein complex8114
GO:0016514SWI/SNF complex315
GO:0007346regulation of mitotic cell cycle330
GO:0006260DNA replication12125
GO:0043274phospholipase binding117
GO:0035019somatic stem cell maintenance240
GO:0001890placenta development134
GO:0003690double-stranded DNA binding491
GO:0003906DNA-(apurinic or apyrimidinic site) lyase activity111
GO:0055007cardiac muscle cell differentiation119
GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process19
GO:0016255attachment of GPI anchor to protein17
GO:0048471perinuclear region of cytoplasm12523
GO:0004022alcohol dehydrogenase (NAD) activity15
GO:0005916fascia adherens113
GO:0006626protein targeting to mitochondrion145
GO:0050748negative regulation of lipoprotein metabolic process12
GO:0007275multicellular organismal development5344
GO:0071455cellular response to hyperoxia17
GO:0070542response to fatty acid114
GO:0090343positive regulation of cell aging12
GO:0008203cholesterol metabolic process159
GO:0019226transmission of nerve impulse116
GO:0003730mRNA 3'-UTR binding229
GO:0007283spermatogenesis6276
GO:0016021integral component of membrane152483
GO:0050770regulation of axonogenesis126
GO:0019843rRNA binding327
GO:0043022ribosome binding328
GO:0018279protein N-linked glycosylation via asparagine291
GO:0030891VCB complex25
GO:0030017sarcomere134
GO:0004090carbonyl reductase (NADPH) activity14
GO:0031264death-inducing signaling complex16
GO:0002360T cell lineage commitment13
GO:0032403protein complex binding7185
GO:0000132establishment of mitotic spindle orientation116
GO:0086009membrane repolarization18
GO:0032587ruffle membrane472
GO:0032092positive regulation of protein binding339
GO:0033512L-lysine catabolic process to acetyl-CoA via saccharopine13
GO:0022008neurogenesis125
GO:0046933proton-transporting ATP synthase activity, rotational mechanism19
GO:0006605protein targeting236
GO:0006432phenylalanyl-tRNA aminoacylation13
GO:0007213G-protein coupled acetylcholine receptor signaling pathway111
GO:0048147negative regulation of fibroblast proliferation124
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I2377
GO:0071339MLL1 complex327
GO:0034599cellular response to oxidative stress136
GO:0015939pantothenate metabolic process110
GO:0035639purine ribonucleoside triphosphate binding11
GO:1903507negative regulation of nucleic acid-templated transcription232
GO:00515755'-deoxyribose-5-phosphate lyase activity24
GO:0033326cerebrospinal fluid secretion15
GO:0045638negative regulation of myeloid cell differentiation116
GO:0006891intra-Golgi vesicle-mediated transport117
GO:0046940nucleoside monophosphate phosphorylation11
GO:0045879negative regulation of smoothened signaling pathway123
GO:0030953astral microtubule organization13
GO:0002224toll-like receptor signaling pathway2109
GO:0010887negative regulation of cholesterol storage16
GO:0034235GPI anchor binding17
GO:0005080protein kinase C binding144
GO:0006273lagging strand elongation14
GO:0007265Ras protein signal transduction375
GO:0033108mitochondrial respiratory chain complex assembly12
GO:0034146toll-like receptor 5 signaling pathway165
GO:0045859regulation of protein kinase activity126
GO:0008217regulation of blood pressure558
GO:0006069ethanol oxidation110
GO:0071222cellular response to lipopolysaccharide181
GO:0006526arginine biosynthetic process13
GO:0043405regulation of MAP kinase activity15
GO:0050482arachidonic acid secretion114
GO:0071930negative regulation of transcription involved in G1/S transition of mitotic cell cycle13
GO:0050681androgen receptor binding438
GO:0032853positive regulation of Ran GTPase activity16
GO:0004798thymidylate kinase activity12
GO:0071377cellular response to glucagon stimulus137
GO:0001702gastrulation with mouth forming second221
GO:2000510positive regulation of dendritic cell chemotaxis14
GO:0051289protein homotetramerization154
GO:0050786RAGE receptor binding111
GO:0042277peptide binding235
GO:0030141secretory granule267
GO:0045719negative regulation of glycogen biosynthetic process18
GO:0000724double-strand break repair via homologous recombination657
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2474
GO:0071942XPC complex13
GO:0006406mRNA export from nucleus162
GO:0046007negative regulation of activated T cell proliferation17
GO:0006475internal protein amino acid acetylation17
GO:0043403skeletal muscle tissue regeneration111
GO:0006369termination of RNA polymerase II transcription245
GO:0032508DNA duplex unwinding442
GO:0033211adiponectin-activated signaling pathway16
GO:0051497negative regulation of stress fiber assembly110
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2470
GO:0061133endopeptidase activator activity15
GO:0034142toll-like receptor 4 signaling pathway296
GO:0045453bone resorption219
GO:0042060wound healing168
GO:0019894kinesin binding128
GO:0005200structural constituent of cytoskeleton793
GO:0006446regulation of translational initiation136
GO:0070374positive regulation of ERK1 and ERK2 cascade1110
GO:0006426glycyl-tRNA aminoacylation11
GO:0021766hippocampus development439
GO:0030199collagen fibril organization137
GO:0030728ovulation18
GO:0006289nucleotide-excision repair1269
GO:0070536protein K63-linked deubiquitination118
GO:0021762substantia nigra development146
GO:0004832valine-tRNA ligase activity12
GO:0008152metabolic process5302
GO:0006184GTP catabolic process9220
GO:0002181cytoplasmic translation16
GO:0016607nuclear speck4175
GO:0003924GTPase activity9203
GO:1901990regulation of mitotic cell cycle phase transition14
GO:0009306protein secretion121
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development17
GO:0005743mitochondrial inner membrane5300
GO:0051099positive regulation of binding17
GO:0060735regulation of eIF2 alpha phosphorylation by dsRNA11
GO:0008150biological_process1459
GO:0004723calcium-dependent protein serine/threonine phosphatase activity12
GO:0007077mitotic nuclear envelope disassembly137
GO:0000278mitotic cell cycle52398
GO:0031464Cul4A-RING E3 ubiquitin ligase complex28
GO:0006878cellular copper ion homeostasis112
GO:0010499proteasomal ubiquitin-independent protein catabolic process14
GO:0005673transcription factor TFIIE complex11
GO:1903038negative regulation of leukocyte cell-cell adhesion11
GO:0032886regulation of microtubule-based process412
GO:0030282bone mineralization133
GO:0097527necroptotic signaling pathway16
GO:0007267cell-cell signaling2224
GO:0008033tRNA processing139
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2465
GO:0006379mRNA cleavage110
GO:0016071mRNA metabolic process34223
GO:0030855epithelial cell differentiation465
GO:0001829trophectodermal cell differentiation117
GO:0034220ion transmembrane transport2167
GO:0046983protein dimerization activity3131
GO:0097110scaffold protein binding234
GO:0051988regulation of attachment of spindle microtubules to kinetochore17
GO:0001570vasculogenesis159
GO:0007158neuron cell-cell adhesion113
GO:0001105RNA polymerase II transcription coactivator activity124
GO:0070885negative regulation of calcineurin-NFAT signaling cascade14
GO:0034613cellular protein localization144
GO:0010575positive regulation vascular endothelial growth factor production123
GO:0006950response to stress348
GO:0050919negative chemotaxis117
GO:0006414translational elongation1193
GO:0050766positive regulation of phagocytosis124
GO:0007179transforming growth factor beta receptor signaling pathway3130
GO:0005829cytosol1252562
GO:0005667transcription factor complex6178
GO:0006144purine nucleobase metabolic process232
GO:0048532anatomical structure arrangement11
GO:0030971receptor tyrosine kinase binding233
GO:0006189'de novo' IMP biosynthetic process16
GO:0000775chromosome, centromeric region252
GO:0008340determination of adult lifespan111
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis577
GO:0040007growth128
GO:0050821protein stabilization291
GO:0032689negative regulation of interferon-gamma production124
GO:0003707steroid hormone receptor activity146
GO:0006385transcription elongation from RNA polymerase III promoter318
GO:0000781chromosome, telomeric region240
GO:0000339RNA cap binding18
GO:0046321positive regulation of fatty acid oxidation13
GO:0000188inactivation of MAPK activity127
GO:0008654phospholipid biosynthetic process115
GO:0038031non-canonical Wnt signaling pathway via JNK cascade15
GO:0031996thioesterase binding214
GO:0014075response to amine19
GO:0045793positive regulation of cell size29
GO:0005789endoplasmic reticulum membrane10636
GO:0006310DNA recombination467
GO:0043200response to amino acid123
GO:0060342photoreceptor inner segment membrane12
GO:0001944vasculature development124
GO:0004745retinol dehydrogenase activity19
GO:0045294alpha-catenin binding18
GO:0004103choline kinase activity12
GO:0006513protein monoubiquitination123
GO:0007497posterior midgut development12
GO:0016469proton-transporting two-sector ATPase complex15
GO:0016573histone acetylation223
GO:0001667ameboidal-type cell migration16
GO:0004842ubiquitin-protein transferase activity4256
GO:0003779actin binding7275
GO:0016757transferase activity, transferring glycosyl groups18
GO:0005112Notch binding115
GO:2000377regulation of reactive oxygen species metabolic process117
GO:0051222positive regulation of protein transport14
GO:0000812Swr1 complex38
GO:0035242protein-arginine omega-N asymmetric methyltransferase activity17
GO:0061001regulation of dendritic spine morphogenesis211
GO:0042177negative regulation of protein catabolic process130
GO:0031490chromatin DNA binding239
GO:0043968histone H2A acetylation312
GO:0002162dystroglycan binding17
GO:0005869dynactin complex18
GO:0042555MCM complex29
GO:0005912adherens junction137
GO:0035264multicellular organism growth170
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors16
GO:0010592positive regulation of lamellipodium assembly112
GO:0031397negative regulation of protein ubiquitination132
GO:0035335peptidyl-tyrosine dephosphorylation294
GO:0006355regulation of transcription, DNA-templated171104
GO:0042624ATPase activity, uncoupled11
GO:0019900kinase binding154
GO:0015992proton transport332
GO:0051219phosphoprotein binding332
GO:0007018microtubule-based movement159
GO:0009409response to cold229
GO:0036376sodium ion export from cell16
GO:0005813centrosome12339
GO:0006890retrograde vesicle-mediated transport, Golgi to ER125
GO:0010467gene expression58669
GO:0034166toll-like receptor 10 signaling pathway165
GO:0071636positive regulation of transforming growth factor beta production15
GO:0007049cell cycle3177
GO:0042981regulation of apoptotic process26151
GO:0071682endocytic vesicle lumen116
GO:2000273positive regulation of receptor activity111
GO:1990259histone-glutamine methyltransferase activity11
GO:0051015actin filament binding297
GO:0006646phosphatidylethanolamine biosynthetic process213
GO:0007601visual perception1168
GO:0000185activation of MAPKKK activity29
GO:0061154endothelial tube morphogenesis15
GO:0042157lipoprotein metabolic process137
GO:0070062extracellular vesicular exosome982516
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway225
GO:0030036actin cytoskeleton organization5129
GO:0030148sphingolipid biosynthetic process126
GO:0003824catalytic activity156
GO:0030375thyroid hormone receptor coactivator activity14
GO:0014069postsynaptic density1106
GO:0050921positive regulation of chemotaxis113
GO:0004197cysteine-type endopeptidase activity252
GO:0008104protein localization356
GO:0008559xenobiotic-transporting ATPase activity13
GO:0090314positive regulation of protein targeting to membrane116
GO:0005662DNA replication factor A complex313
GO:0031941filamentous actin123
GO:0042995cell projection663
GO:0006657CDP-choline pathway17
GO:0005506iron ion binding3127
GO:0031461cullin-RING ubiquitin ligase complex15
GO:0036152phosphatidylethanolamine acyl-chain remodeling118
GO:0043044ATP-dependent chromatin remodeling423
GO:0005739mitochondrion241046
GO:0050431transforming growth factor beta binding115
GO:0044027hypermethylation of CpG island13
GO:0043548phosphatidylinositol 3-kinase binding121
GO:0000902cell morphogenesis251
GO:0042552myelination136
GO:0021549cerebellum development130
GO:2000785regulation of autophagic vacuole assembly17
GO:0031265CD95 death-inducing signaling complex16
GO:0008432JUN kinase binding16
GO:0050434positive regulation of viral transcription544
GO:0050790regulation of catalytic activity369
GO:0009887organ morphogenesis289
GO:0097194execution phase of apoptosis120
GO:0072661protein targeting to plasma membrane119
GO:0008601protein phosphatase type 2A regulator activity320
GO:0060318definitive erythrocyte differentiation14
GO:0051260protein homooligomerization1150
GO:0006378mRNA polyadenylation122
GO:0045672positive regulation of osteoclast differentiation119
GO:0046696lipopolysaccharide receptor complex15
GO:2001295malonyl-CoA biosynthetic process12
GO:0000105histidine biosynthetic process12
GO:1903078positive regulation of protein localization to plasma membrane13
GO:2000738positive regulation of stem cell differentiation15
GO:0004714transmembrane receptor protein tyrosine kinase activity230
GO:0036150phosphatidylserine acyl-chain remodeling112
GO:0070372regulation of ERK1 and ERK2 cascade117
GO:0010043response to zinc ion126
GO:0021591ventricular system development113
GO:0005680anaphase-promoting complex420
GO:0018107peptidyl-threonine phosphorylation137
GO:0071564npBAF complex211
GO:0032558adenyl deoxyribonucleotide binding11
GO:0032764negative regulation of mast cell cytokine production12
GO:0032880regulation of protein localization137
GO:0006461protein complex assembly6111
GO:0030957Tat protein binding46
GO:0071456cellular response to hypoxia498
GO:0016578histone deubiquitination111
GO:0000248C-5 sterol desaturase activity12
GO:0031072heat shock protein binding233
GO:0005956protein kinase CK2 complex11
GO:0042470melanosome1092
GO:0097342ripoptosome17
GO:0090103cochlea morphogenesis221
GO:0005977glycogen metabolic process124
GO:0045071negative regulation of viral genome replication134
GO:0017145stem cell division17
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway110
GO:0050870positive regulation of T cell activation117
GO:0001841neural tube formation111
GO:0019898extrinsic component of membrane146
GO:0019838growth factor binding125
GO:0043025neuronal cell body4254
GO:0005178integrin binding297
GO:0005887integral component of plasma membrane7961
GO:0046939nucleotide phosphorylation113
GO:0033619membrane protein proteolysis16
GO:0050806positive regulation of synaptic transmission112
GO:0005764lysosome2182
GO:0000790nuclear chromatin7133
GO:0003887DNA-directed DNA polymerase activity329
GO:0060322head development19
GO:0031430M band119
GO:0031497chromatin assembly17
GO:0050851antigen receptor-mediated signaling pathway15
GO:0010944negative regulation of transcription by competitive promoter binding110
GO:0030324lung development176
GO:0050805negative regulation of synaptic transmission14
GO:0000354cis assembly of pre-catalytic spliceosome12
GO:0007406negative regulation of neuroblast proliferation16
GO:0005164tumor necrosis factor receptor binding330
GO:0071318cellular response to ATP110
GO:0008853exodeoxyribonuclease III activity14
GO:0009651response to salt stress214
GO:0006397mRNA processing3169
GO:0030424axon3172
GO:0016070RNA metabolic process34247
GO:0004712protein serine/threonine/tyrosine kinase activity129
GO:0032319regulation of Rho GTPase activity29
GO:0006298mismatch repair620
GO:0030234enzyme regulator activity313
GO:0004070aspartate carbamoyltransferase activity11
GO:0043507positive regulation of JUN kinase activity228
GO:0044212transcription regulatory region DNA binding6171
GO:0007568aging3123
GO:0000930gamma-tubulin complex17
GO:0050966detection of mechanical stimulus involved in sensory perception of pain18
GO:0048260positive regulation of receptor-mediated endocytosis113
GO:0006303double-strand break repair via nonhomologous end joining318
GO:0019371cyclooxygenase pathway114
GO:0016323basolateral plasma membrane3149
GO:0030863cortical cytoskeleton122
GO:0001865NK T cell differentiation12
GO:0031000response to caffeine29
GO:0061146Peyer's patch morphogenesis13
GO:0019233sensory perception of pain149
GO:0032465regulation of cytokinesis114
GO:0000118histone deacetylase complex128
GO:0086004regulation of cardiac muscle cell contraction111
GO:0006622protein targeting to lysosome110
GO:0030687preribosome, large subunit precursor13
GO:0005525GTP binding11328
GO:0042113B cell activation225
GO:0031394positive regulation of prostaglandin biosynthetic process15
GO:0032735positive regulation of interleukin-12 production125
GO:0021819layer formation in cerebral cortex111
GO:0030976thiamine pyrophosphate binding15
GO:0036477somatodendritic compartment12
GO:0031589cell-substrate adhesion116
GO:0005578proteinaceous extracellular matrix1183
GO:0016018cyclosporin A binding17
GO:0030224monocyte differentiation116
GO:0022027interkinetic nuclear migration19
GO:0048008platelet-derived growth factor receptor signaling pathway127
GO:0006266DNA ligation15
GO:0035371microtubule plus-end114
GO:0045502dynein binding211
GO:0042593glucose homeostasis189
GO:0044255cellular lipid metabolic process4140
GO:0042772DNA damage response, signal transduction resulting in transcription11
GO:0030315T-tubule137
GO:0051894positive regulation of focal adhesion assembly118
GO:1900029positive regulation of ruffle assembly15
GO:0071549cellular response to dexamethasone stimulus120
GO:0044770cell cycle phase transition15
GO:0045667regulation of osteoblast differentiation110
GO:0045945positive regulation of transcription from RNA polymerase III promoter111
GO:0010008endosome membrane6157
GO:0008565protein transporter activity257
GO:0051087chaperone binding659
GO:0002842positive regulation of T cell mediated immune response to tumor cell11
GO:0048870cell motility116
GO:0004955prostaglandin receptor activity11
GO:0042256mature ribosome assembly15
GO:0009168purine ribonucleoside monophosphate biosynthetic process112
GO:0030145manganese ion binding141
GO:0051291protein heterooligomerization157
GO:0045931positive regulation of mitotic cell cycle126
GO:0004674protein serine/threonine kinase activity6312
GO:0002009morphogenesis of an epithelium112
GO:0035064methylated histone binding147
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway171
GO:0009249protein lipoylation15
GO:0001516prostaglandin biosynthetic process114
GO:0046655folic acid metabolic process110
GO:0044209AMP salvage12
GO:0070294renal sodium ion absorption14
GO:00084095'-3' exonuclease activity19
GO:0090271positive regulation of fibroblast growth factor production11
GO:0023014signal transduction by phosphorylation130
GO:0001822kidney development379
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process119
GO:0032496response to lipopolysaccharide4122
GO:0051781positive regulation of cell division139
GO:0006368transcription elongation from RNA polymerase II promoter667
GO:0030286dynein complex113
GO:0048839inner ear development238
GO:0070064proline-rich region binding218
GO:0035493SNARE complex assembly17
GO:0006531aspartate metabolic process16
GO:0032727positive regulation of interferon-alpha production111
GO:0005793endoplasmic reticulum-Golgi intermediate compartment157
GO:0010424DNA methylation on cytosine within a CG sequence13
GO:0001816cytokine production125
GO:0050661NADP binding132
GO:0000235astral microtubule11
GO:0014043negative regulation of neuron maturation13
GO:0006607NLS-bearing protein import into nucleus214
GO:0003774motor activity244
GO:0000701purine-specific mismatch base pair DNA N-glycosylase activity11
GO:0071306cellular response to vitamin E12
GO:0048666neuron development135
GO:0008026ATP-dependent helicase activity339
GO:0019005SCF ubiquitin ligase complex129
GO:0045216cell-cell junction organization259
GO:0035925mRNA 3'-UTR AU-rich region binding16
GO:0009395phospholipid catabolic process111
GO:0043652engulfment of apoptotic cell13
GO:0051262protein tetramerization330
GO:0002551mast cell chemotaxis14
GO:0007000nucleolus organization14
GO:0006665sphingolipid metabolic process268
GO:0007628adult walking behavior129
GO:0031622positive regulation of fever generation25
GO:0043235receptor complex2104
GO:0090073positive regulation of protein homodimerization activity17
GO:0048291isotype switching to IgG isotypes11
GO:0097286iron ion import12
GO:0051607defense response to virus1134
GO:0006351transcription, DNA-templated251585
GO:0030118clathrin coat16
GO:0015991ATP hydrolysis coupled proton transport428
GO:0006693prostaglandin metabolic process111
GO:0030133transport vesicle147
GO:0006235dTTP biosynthetic process13
GO:0042551neuron maturation211
GO:0005615extracellular space171010
GO:0031124mRNA 3'-end processing242
GO:0060693regulation of branching involved in salivary gland morphogenesis14
GO:0004488methylenetetrahydrofolate dehydrogenase (NADP+) activity14
GO:0006112energy reserve metabolic process199
GO:0045715negative regulation of low-density lipoprotein particle receptor biosynthetic process13
GO:0007369gastrulation121
GO:0043032positive regulation of macrophage activation110
GO:0050145nucleoside phosphate kinase activity12
GO:0007174epidermal growth factor catabolic process11
GO:0001523retinoid metabolic process250
GO:0007202activation of phospholipase C activity158
GO:0031528microvillus membrane117
GO:0008195phosphatidate phosphatase activity110
GO:0010669epithelial structure maintenance14
GO:0015035protein disulfide oxidoreductase activity121
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription240
GO:0051146striated muscle cell differentiation112
GO:0031295T cell costimulation167
GO:0007616long-term memory127
GO:0007611learning or memory234
GO:0008574plus-end-directed microtubule motor activity115
GO:0005839proteasome core complex1118
GO:0097208alveolar lamellar body16
GO:0050727regulation of inflammatory response347
GO:0071158positive regulation of cell cycle arrest119
GO:0031519PcG protein complex425
GO:0006200ATP catabolic process14303
GO:0080008Cul4-RING E3 ubiquitin ligase complex114
GO:0030904retromer complex215
GO:0030335positive regulation of cell migration6130
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity19
GO:0006096glycolytic process439
GO:0001846opsonin binding12
GO:0060087relaxation of vascular smooth muscle17
GO:0007566embryo implantation136
GO:0005391sodium:potassium-exchanging ATPase activity18
GO:0050998nitric-oxide synthase binding116
GO:0002903negative regulation of B cell apoptotic process16
GO:0045716positive regulation of low-density lipoprotein particle receptor biosynthetic process14
GO:0060020Bergmann glial cell differentiation14
GO:0005640nuclear outer membrane123
GO:1900126negative regulation of hyaluronan biosynthetic process13
GO:0046697decidualization119
GO:0060557positive regulation of vitamin D biosynthetic process12
GO:0048562embryonic organ morphogenesis15
GO:0050690regulation of defense response to virus by virus128
GO:0071418cellular response to amine stimulus12
GO:0010800positive regulation of peptidyl-threonine phosphorylation118
GO:0008536Ran GTPase binding225
GO:0055088lipid homeostasis119
GO:0006047UDP-N-acetylglucosamine metabolic process13
GO:0019773proteasome core complex, alpha-subunit complex58
GO:0002244hematopoietic progenitor cell differentiation158
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex115
GO:0045893positive regulation of transcription, DNA-templated17487
GO:0010225response to UV-C110
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway261
GO:0042254ribosome biogenesis130
GO:0070626(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity11
GO:0052066entry of symbiont into host cell by promotion of host phagocytosis11
GO:0060291long-term synaptic potentiation130
GO:0051798positive regulation of hair follicle development15
GO:0051272positive regulation of cellular component movement111
GO:0007264small GTPase mediated signal transduction3290
GO:0070307lens fiber cell development210
GO:0033572transferrin transport632
GO:0071353cellular response to interleukin-4120
GO:0001701in utero embryonic development6210
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription162
GO:0061034olfactory bulb mitral cell layer development12
GO:0010571positive regulation of nuclear cell cycle DNA replication15
GO:0048484enteric nervous system development112
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II492
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process163
GO:0043248proteasome assembly15
GO:0005903brush border124
GO:0030016myofibril125
GO:0005102receptor binding5268
GO:0071109superior temporal gyrus development12
GO:0050544arachidonic acid binding15
GO:0030890positive regulation of B cell proliferation135
GO:0044267cellular protein metabolic process24495
GO:2000601positive regulation of Arp2/3 complex-mediated actin nucleation16
GO:0048205COPI coating of Golgi vesicle113
GO:0002674negative regulation of acute inflammatory response17
GO:0043564Ku70:Ku80 complex12
GO:0005856cytoskeleton8311
GO:0000910cytokinesis151
GO:0043220Schmidt-Lanterman incisure112
GO:0007403glial cell fate determination13
GO:0004750ribulose-phosphate 3-epimerase activity11
GO:0006744ubiquinone biosynthetic process111
GO:0004386helicase activity456
GO:0001765membrane raft assembly14
GO:0030914STAGA complex113
GO:0002756MyD88-independent toll-like receptor signaling pathway278
GO:0030828positive regulation of cGMP biosynthetic process16
GO:0043596nuclear replication fork18
GO:1900121negative regulation of receptor binding13
GO:0004477methenyltetrahydrofolate cyclohydrolase activity14
GO:0043406positive regulation of MAP kinase activity247
GO:0051059NF-kappaB binding325
GO:0070266necroptotic process112
GO:0043550regulation of lipid kinase activity14
GO:0003975UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity11
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)12
GO:0043491protein kinase B signaling132
GO:0009051pentose-phosphate shunt, oxidative branch13
GO:0004839ubiquitin activating enzyme activity14
GO:0061077chaperone-mediated protein folding231
GO:0006422aspartyl-tRNA aminoacylation11
GO:0035458cellular response to interferon-beta211
GO:0034103regulation of tissue remodeling13
GO:0008080N-acetyltransferase activity110
GO:0004871signal transducer activity4216
GO:0035999tetrahydrofolate interconversion17
GO:0035567non-canonical Wnt signaling pathway15
GO:0046456icosanoid biosynthetic process12
GO:0046134pyrimidine nucleoside biosynthetic process16
GO:0022607cellular component assembly11
GO:0001085RNA polymerase II transcription factor binding234
GO:0002250adaptive immune response132
GO:0070262peptidyl-serine dephosphorylation11
GO:0006979response to oxidative stress490
GO:0000075cell cycle checkpoint29
GO:0015966diadenosine tetraphosphate biosynthetic process12
GO:0071479cellular response to ionizing radiation125
GO:0001056RNA polymerase III activity316
GO:0000400four-way junction DNA binding19
GO:0010468regulation of gene expression172
GO:0034435cholesterol esterification12
GO:0030216keratinocyte differentiation147
GO:0004632phosphopantothenate--cysteine ligase activity11
GO:0090107regulation of high-density lipoprotein particle assembly11
GO:0004815aspartate-tRNA ligase activity12
GO:0045727positive regulation of translation446
GO:0033088negative regulation of immature T cell proliferation in thymus14
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity593
GO:0005681spliceosomal complex383
GO:0033574response to testosterone222
GO:0030042actin filament depolymerization28
GO:0004175endopeptidase activity234
GO:0043231intracellular membrane-bounded organelle8332
GO:0019521D-gluconate metabolic process11
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay153
GO:0042975peroxisome proliferator activated receptor binding111
GO:0001530lipopolysaccharide binding213
GO:0060749mammary gland alveolus development115
GO:0035690cellular response to drug250
GO:0035666TRIF-dependent toll-like receptor signaling pathway276
GO:0001158enhancer sequence-specific DNA binding117
GO:0071535RING-like zinc finger domain binding13
GO:0046826negative regulation of protein export from nucleus17
GO:0033613activating transcription factor binding118
GO:0000159protein phosphatase type 2A complex220
GO:0004364glutathione transferase activity121
GO:0043973histone H3-K4 acetylation11
GO:0030126COPI vesicle coat113
GO:0046902regulation of mitochondrial membrane permeability110
GO:0045600positive regulation of fat cell differentiation135
GO:0070577lysine-acetylated histone binding117
GO:0001891phagocytic cup216
GO:0045987positive regulation of smooth muscle contraction115
GO:0035025positive regulation of Rho protein signal transduction110
GO:0071897DNA biosynthetic process229
GO:0003777microtubule motor activity160
GO:0051403stress-activated MAPK cascade154
GO:0004843ubiquitin-specific protease activity166
GO:0032755positive regulation of interleukin-6 production236
GO:0031225anchored component of membrane187
GO:0008305integrin complex123
GO:0045335phagocytic vesicle233
GO:0006357regulation of transcription from RNA polymerase II promoter6275
GO:0050699WW domain binding121
GO:0034364high-density lipoprotein particle120
GO:0015629actin cytoskeleton5183
GO:0005819spindle7114
GO:0045860positive regulation of protein kinase activity145
GO:0016311dephosphorylation394
GO:0002055adenine binding11
GO:0005634nucleus1314828
GO:0015459potassium channel regulator activity126
GO:0071236cellular response to antibiotic112
GO:0006417regulation of translation163
GO:0042346positive regulation of NF-kappaB import into nucleus218
GO:0035257nuclear hormone receptor binding119
GO:0010614negative regulation of cardiac muscle hypertrophy16
GO:0060762regulation of branching involved in mammary gland duct morphogenesis16
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling3148
GO:0002368B cell cytokine production11
GO:0010971positive regulation of G2/M transition of mitotic cell cycle112
GO:0006672ceramide metabolic process115
GO:0045445myoblast differentiation215
GO:0031674I band118
GO:0003735structural constituent of ribosome8141
GO:0035267NuA4 histone acetyltransferase complex414
GO:0005765lysosomal membrane5218
GO:0007250activation of NF-kappaB-inducing kinase activity119
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling111
GO:0007091metaphase/anaphase transition of mitotic cell cycle17
GO:0006958complement activation, classical pathway136
GO:0019985translesion synthesis212
GO:0009108coenzyme biosynthetic process16
GO:0006418tRNA aminoacylation for protein translation542
GO:0000774adenyl-nucleotide exchange factor activity14
GO:0033138positive regulation of peptidyl-serine phosphorylation361
GO:0048713regulation of oligodendrocyte differentiation14
GO:0010950positive regulation of endopeptidase activity17
GO:0006488dolichol-linked oligosaccharide biosynthetic process133
GO:0000212meiotic spindle organization14
GO:0048821erythrocyte development115
GO:0005730nucleolus701684
GO:0006935chemotaxis1108
GO:0031527filopodium membrane117
GO:0006874cellular calcium ion homeostasis176
GO:0030057desmosome123
GO:0001055RNA polymerase II activity38
GO:0007612learning146
GO:0031274positive regulation of pseudopodium assembly110
GO:0030163protein catabolic process122
GO:0016922ligand-dependent nuclear receptor binding118
GO:0016992lipoate synthase activity11
GO:2000774positive regulation of cellular senescence14
GO:0006913nucleocytoplasmic transport227
GO:0010871negative regulation of receptor biosynthetic process13
GO:0048255mRNA stabilization112
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator214
GO:0005790smooth endoplasmic reticulum122
GO:0019369arachidonic acid metabolic process249
GO:0007386compartment pattern specification14
GO:0030130clathrin coat of trans-Golgi network vesicle16
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus117
GO:0019901protein kinase binding21320
GO:0006541glutamine metabolic process118
GO:0034372very-low-density lipoprotein particle remodeling17
GO:0009791post-embryonic development175
GO:0005911cell-cell junction3142
GO:0003823antigen binding128
GO:0000209protein polyubiquitination21116
GO:0009086methionine biosynthetic process15
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway326
GO:0042974retinoic acid receptor binding113
GO:0060632regulation of microtubule-based movement13
GO:0051081nuclear envelope disassembly12
GO:0038027apolipoprotein A-I-mediated signaling pathway15
GO:0042176regulation of protein catabolic process316
GO:0043011myeloid dendritic cell differentiation115
GO:0070914UV-damage excision repair17
GO:0005788endoplasmic reticulum lumen1157
GO:0017048Rho GTPase binding131
GO:0046982protein heterodimerization activity11399
GO:0016567protein ubiquitination5299
GO:0045785positive regulation of cell adhesion541
GO:0006450regulation of translational fidelity210
GO:0048284organelle fusion11
GO:0006684sphingomyelin metabolic process14
GO:0007186G-protein coupled receptor signaling pathway5367
GO:0060171stereocilium membrane12
GO:0016363nuclear matrix1192
GO:0070545PeBoW complex13
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic process22
GO:0001657ureteric bud development139
GO:0031623receptor internalization131
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity459
GO:0071346cellular response to interferon-gamma123
GO:0006428isoleucyl-tRNA aminoacylation12
GO:0051668localization within membrane12
GO:0071850mitotic cell cycle arrest111
GO:0003923GPI-anchor transamidase activity15
GO:0004756selenide, water dikinase activity12
GO:0022028tangential migration from the subventricular zone to the olfactory bulb13
GO:0006413translational initiation12131
GO:0034612response to tumor necrosis factor228
GO:0030198extracellular matrix organization3295
GO:0042393histone binding371
GO:0005759mitochondrial matrix12233
GO:0001739sex chromatin17
GO:0002161aminoacyl-tRNA editing activity27
GO:0010226response to lithium ion210
GO:0033077T cell differentiation in thymus233
GO:0043195terminal bouton141
GO:0046474glycerophospholipid biosynthetic process376
GO:0010745negative regulation of macrophage derived foam cell differentiation213
GO:0006325chromatin organization4123
GO:0000015phosphopyruvate hydratase complex24
GO:0004506squalene monooxygenase activity11
GO:0005198structural molecule activity4159
GO:0033630positive regulation of cell adhesion mediated by integrin111
GO:0042026protein refolding215
GO:0051603proteolysis involved in cellular protein catabolic process216
GO:0000466maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)12
GO:0034185apolipoprotein binding114
GO:0019408dolichol biosynthetic process11
GO:0070371ERK1 and ERK2 cascade118
GO:0046677response to antibiotic231
GO:0004860protein kinase inhibitor activity221
GO:0017080sodium channel regulator activity122
GO:0060048cardiac muscle contraction139
GO:0016604nuclear body231
GO:0020037heme binding2111
GO:0008289lipid binding1116
GO:0032402melanosome transport120
GO:0034641cellular nitrogen compound metabolic process25177
GO:0046034ATP metabolic process116
GO:0006284base-excision repair739
GO:0060026convergent extension15
GO:0000139Golgi membrane2408
GO:0048156tau protein binding19
GO:0014042positive regulation of neuron maturation13
GO:0006921cellular component disassembly involved in execution phase of apoptosis547
GO:0008270zinc ion binding121067
GO:0005923tight junction292
GO:0071920cleavage body12
GO:0047496vesicle transport along microtubule112
GO:0002037negative regulation of L-glutamate transport11
GO:0000718nucleotide-excision repair, DNA damage removal521
GO:0007420brain development1172
GO:0001842neural fold formation14
GO:0043923positive regulation by host of viral transcription211
GO:0005179hormone activity184
GO:0060766negative regulation of androgen receptor signaling pathway113
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway140
GO:0031965nuclear membrane4176
GO:0001755neural crest cell migration230
GO:0019003GDP binding248
GO:0048709oligodendrocyte differentiation123
GO:0050774negative regulation of dendrite morphogenesis16
GO:0005622intracellular5226
GO:0006364rRNA processing596
GO:0032609interferon-gamma production19
GO:0071733transcriptional activation by promoter-enhancer looping13
GO:0005637nuclear inner membrane128
GO:0007219Notch signaling pathway4125
GO:1903543positive regulation of exosomal secretion112
GO:0007399nervous system development2245
GO:0005524ATP binding461354
GO:0042645mitochondrial nucleoid239
GO:0016049cell growth150
GO:0044281small molecule metabolic process571295
GO:0008333endosome to lysosome transport129
GO:0033180proton-transporting V-type ATPase, V1 domain27
GO:0071169establishment of protein localization to chromatin15
GO:0035985senescence-associated heterochromatin focus13
GO:0048261negative regulation of receptor-mediated endocytosis16
GO:0001895retina homeostasis136
GO:0010508positive regulation of autophagy122
GO:0045780positive regulation of bone resorption113
GO:0046716muscle cell cellular homeostasis216
GO:0007020microtubule nucleation114
GO:0006228UTP biosynthetic process19
GO:0034969histone arginine methylation14
GO:0006297nucleotide-excision repair, DNA gap filling522
GO:0006164purine nucleotide biosynthetic process28
GO:0005844polysome425
GO:0043687post-translational protein modification4181
GO:0030867rough endoplasmic reticulum membrane17
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors234
GO:0034976response to endoplasmic reticulum stress152
GO:0030054cell junction2356
GO:0039692single stranded viral RNA replication via double stranded DNA intermediate12
GO:0014002astrocyte development111
GO:0032355response to estradiol573
GO:0000731DNA synthesis involved in DNA repair110
GO:0003682chromatin binding12334
GO:0035116embryonic hindlimb morphogenesis130
GO:0008045motor neuron axon guidance120
GO:0019722calcium-mediated signaling140
GO:0007409axonogenesis166
GO:0001933negative regulation of protein phosphorylation139
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding554
GO:0016042lipid catabolic process152
GO:0005544calcium-dependent phospholipid binding232
GO:0003714transcription corepressor activity7179
GO:0051926negative regulation of calcium ion transport113
GO:0009396folic acid-containing compound biosynthetic process14
GO:0038089positive regulation of cell migration by vascular endothelial growth factor signaling pathway11
GO:0007194negative regulation of adenylate cyclase activity121
GO:0003009skeletal muscle contraction119
GO:0001835blastocyst hatching24
GO:0005497androgen binding13
GO:0051276chromosome organization416
GO:0030111regulation of Wnt signaling pathway112
GO:0010976positive regulation of neuron projection development160
GO:0031467Cul7-RING ubiquitin ligase complex14
GO:0006900membrane budding15
GO:0043409negative regulation of MAPK cascade113
GO:0007249I-kappaB kinase/NF-kappaB signaling141
GO:0033762response to glucagon111
GO:0007605sensory perception of sound1111
GO:0048025negative regulation of mRNA splicing, via spliceosome115
GO:00082963'-5'-exodeoxyribonuclease activity12
GO:0022627cytosolic small ribosomal subunit339
GO:0033179proton-transporting V-type ATPase, V0 domain16
GO:0016791phosphatase activity118
GO:0031683G-protein beta/gamma-subunit complex binding121
GO:0008201heparin binding2127
GO:0008543fibroblast growth factor receptor signaling pathway4159
GO:1990258histone glutamine methylation11
GO:0045647negative regulation of erythrocyte differentiation17
GO:0009055electron carrier activity168
GO:0044208'de novo' AMP biosynthetic process13
GO:0006749glutathione metabolic process129
GO:0007266Rho protein signal transduction248
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane126
GO:0031334positive regulation of protein complex assembly214
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding175
GO:0006261DNA-dependent DNA replication215
GO:0042158lipoprotein biosynthetic process15
GO:0006656phosphatidylcholine biosynthetic process322
GO:0007595lactation239
GO:0071803positive regulation of podosome assembly15
GO:0007339binding of sperm to zona pellucida127
GO:0005055laminin receptor activity12
GO:0006610ribosomal protein import into nucleus14
GO:0000166nucleotide binding6272
GO:0018108peptidyl-tyrosine phosphorylation3133
GO:0004715non-membrane spanning protein tyrosine kinase activity142
GO:0072341modified amino acid binding17
GO:0048854brain morphogenesis115
GO:0000785chromatin573
GO:0006356regulation of transcription from RNA polymerase I promoter26
GO:0048813dendrite morphogenesis131
GO:0008013beta-catenin binding460
GO:0045298tubulin complex13
GO:0043380regulation of memory T cell differentiation11
GO:0031410cytoplasmic vesicle2110
GO:2000536negative regulation of entry of bacterium into host cell11
GO:0048568embryonic organ development114
GO:0005801cis-Golgi network135
GO:0045471response to ethanol188
GO:0000738DNA catabolic process, exonucleolytic213
GO:0070063RNA polymerase binding19
GO:0036464cytoplasmic ribonucleoprotein granule422
GO:1903077negative regulation of protein localization to plasma membrane14
GO:0006766vitamin metabolic process378
GO:0006270DNA replication initiation522
GO:0006730one-carbon metabolic process126
GO:0044130negative regulation of growth of symbiont in host117
GO:0006508proteolysis9410
GO:0008266poly(U) RNA binding113
GO:0071380cellular response to prostaglandin E stimulus19
GO:0000082G1/S transition of mitotic cell cycle33150
GO:0004666prostaglandin-endoperoxide synthase activity12
GO:0090336positive regulation of brown fat cell differentiation13
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process13
GO:1901558response to metformin11
GO:0090382phagosome maturation538
GO:2000010positive regulation of protein localization to cell surface28
GO:0071475cellular hyperosmotic salinity response12
GO:0017144drug metabolic process125
GO:0009798axis specification12
GO:0045823positive regulation of heart contraction15
GO:0031947negative regulation of glucocorticoid biosynthetic process11
GO:0002026regulation of the force of heart contraction117
GO:0005890sodium:potassium-exchanging ATPase complex110
GO:0051131chaperone-mediated protein complex assembly113
GO:0050473arachidonate 15-lipoxygenase activity13
GO:0021756striatum development110
GO:0006888ER to Golgi vesicle-mediated transport255
GO:0060100positive regulation of phagocytosis, engulfment15
GO:0042562hormone binding116
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process344
GO:0051443positive regulation of ubiquitin-protein transferase activity115
GO:0050796regulation of insulin secretion282
GO:0003756protein disulfide isomerase activity122
GO:0015078hydrogen ion transmembrane transporter activity320
GO:0001525angiogenesis4200
GO:0030136clathrin-coated vesicle146
GO:0006091generation of precursor metabolites and energy351
GO:0060546negative regulation of necroptotic process17
GO:0051974negative regulation of telomerase activity18
GO:0010107potassium ion import113
GO:0000018regulation of DNA recombination16
GO:0031333negative regulation of protein complex assembly114
GO:0031252cell leading edge329
GO:0003677DNA binding261351
GO:0004198calcium-dependent cysteine-type endopeptidase activity115
GO:0031593polyubiquitin binding123
GO:2000230negative regulation of pancreatic stellate cell proliferation11
GO:0090383phagosome acidification14
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process15
GO:0017124SH3 domain binding3115
GO:0010666positive regulation of cardiac muscle cell apoptotic process16
GO:0010506regulation of autophagy123
GO:0010811positive regulation of cell-substrate adhesion135
GO:0002502peptide antigen assembly with MHC class I protein complex11
GO:0006810transport1270
GO:0009650UV protection112
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process136
GO:0004872receptor activity3199
GO:0021846cell proliferation in forebrain111
GO:0001221transcription cofactor binding16
GO:0045670regulation of osteoclast differentiation18
GO:0048010vascular endothelial growth factor receptor signaling pathway121
GO:0005682U5 snRNP16
GO:0017025TBP-class protein binding218
GO:0090305nucleic acid phosphodiester bond hydrolysis254
GO:0000045autophagic vacuole assembly126
GO:0071392cellular response to estradiol stimulus118
GO:0016310phosphorylation295
GO:0071922regulation of cohesin localization to chromatin14
GO:0006349regulation of gene expression by genetic imprinting115
GO:0000733DNA strand renaturation18
GO:0051028mRNA transport254
GO:0007051spindle organization112
GO:0045822negative regulation of heart contraction16
GO:0017157regulation of exocytosis118
GO:0001756somitogenesis138
GO:0004888transmembrane signaling receptor activity1103
GO:0072089stem cell proliferation17
GO:0009653anatomical structure morphogenesis287
GO:0004221ubiquitin thiolesterase activity236
GO:0044548S100 protein binding111
GO:0005504fatty acid binding114
GO:0048015phosphatidylinositol-mediated signaling3115
GO:0030898actin-dependent ATPase activity112
GO:0001849complement component C1q binding17
GO:0042149cellular response to glucose starvation117
GO:0048546digestive tract morphogenesis114
GO:0035255ionotropic glutamate receptor binding117
GO:0060021palate development173
GO:0042633hair cycle112
GO:0006974cellular response to DNA damage stimulus8158
GO:0031463Cul3-RING ubiquitin ligase complex223
GO:0043137DNA replication, removal of RNA primer14
GO:0007285primary spermatocyte growth11
GO:0031209SCAR complex18
GO:1902108regulation of mitochondrial membrane permeability involved in apoptotic process16
GO:0043236laminin binding123
GO:0035861site of double-strand break118
GO:0032077positive regulation of deoxyribonuclease activity11
GO:0030246carbohydrate binding1151
GO:0048387negative regulation of retinoic acid receptor signaling pathway111
GO:0031100organ regeneration450
GO:0008180COP9 signalosome134
GO:0045668negative regulation of osteoblast differentiation137
GO:0007165signal transduction17950
GO:0051409response to nitrosative stress14
GO:0005669transcription factor TFIID complex122
GO:0046777protein autophosphorylation3158
GO:0070243regulation of thymocyte apoptotic process11
GO:0002634regulation of germinal center formation14
GO:0019372lipoxygenase pathway112
GO:0000151ubiquitin ligase complex163
GO:0051726regulation of cell cycle3102
GO:0006629lipid metabolic process2100
GO:0001968fibronectin binding125
GO:0048873homeostasis of number of cells within a tissue120
GO:0000320re-entry into mitotic cell cycle13
GO:0003016respiratory system process19
GO:0005901caveola363
GO:0031113regulation of microtubule polymerization13
GO:0050853B cell receptor signaling pathway130
GO:0032071regulation of endodeoxyribonuclease activity12
GO:0001709cell fate determination114
GO:0006101citrate metabolic process16
GO:0006954inflammatory response6289
GO:0003999adenine phosphoribosyltransferase activity11
GO:0030176integral component of endoplasmic reticulum membrane257
GO:0006554lysine catabolic process28
GO:0019083viral transcription881
GO:0008134transcription factor binding8246
GO:0034774secretory granule lumen112
GO:0005783endoplasmic reticulum9610
GO:0003746translation elongation factor activity317
GO:0007263nitric oxide mediated signal transduction217
GO:0004716receptor signaling protein tyrosine kinase activity19
GO:0016274protein-arginine N-methyltransferase activity14
GO:0019058viral life cycle10115
GO:0030426growth cone397
GO:0043065positive regulation of apoptotic process8274
GO:0045087innate immune response20616
GO:0055037recycling endosome273
GO:0009612response to mechanical stimulus254
GO:0070852cell body fiber15
GO:0032855positive regulation of Rac GTPase activity136
GO:0016032viral process55540
GO:0048273mitogen-activated protein kinase p38 binding14
GO:0015937coenzyme A biosynthetic process19
GO:0001666response to hypoxia2150
GO:0010042response to manganese ion16
GO:0008022protein C-terminus binding4161
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress124
GO:0004607phosphatidylcholine-sterol O-acyltransferase activity11
GO:0006367transcription initiation from RNA polymerase II promoter8184
GO:0031616spindle pole centrosome18
GO:0045595regulation of cell differentiation121
GO:0048294negative regulation of isotype switching to IgE isotypes13
GO:0034394protein localization to cell surface119
GO:0045120pronucleus111
GO:0045022early endosome to late endosome transport115
GO:0050872white fat cell differentiation112
GO:0035556intracellular signal transduction6317
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane132
GO:0050995negative regulation of lipid catabolic process113
GO:0060416response to growth hormone17
GO:0001934positive regulation of protein phosphorylation5108
GO:0006470protein dephosphorylation199
GO:0005871kinesin complex244
GO:0043085positive regulation of catalytic activity163
GO:0032549ribonucleoside binding24
GO:0004298threonine-type endopeptidase activity1120
GO:0002039p53 binding755
GO:0000800lateral element18
GO:0009374biotin binding15
GO:0006366transcription from RNA polymerase II promoter12425
GO:0031258lamellipodium membrane217
GO:0043401steroid hormone mediated signaling pathway152
GO:0001855complement component C4b binding12
GO:0004329formate-tetrahydrofolate ligase activity14
GO:0036035osteoclast development22
GO:0031116positive regulation of microtubule polymerization211
GO:0034644cellular response to UV532
GO:0008090retrograde axon cargo transport16
GO:0005604basement membrane168
GO:0042826histone deacetylase binding174
GO:0031512motile primary cilium18
GO:0045494photoreceptor cell maintenance127
GO:0004623phospholipase A2 activity113
GO:0032784regulation of DNA-templated transcription, elongation112
GO:0075733intracellular transport of virus217
GO:0000050urea cycle111
GO:0000502proteasome complex2258
GO:0000122negative regulation of transcription from RNA polymerase II promoter12589
GO:0090398cellular senescence120
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation126
GO:0048265response to pain116
GO:0046961proton-transporting ATPase activity, rotational mechanism315
GO:0043525positive regulation of neuron apoptotic process246
GO:0050900leukocyte migration1111
GO:0005758mitochondrial intermembrane space162
GO:0032526response to retinoic acid148
GO:0051090regulation of sequence-specific DNA binding transcription factor activity120
GO:0032869cellular response to insulin stimulus364
GO:0035033histone deacetylase regulator activity13
GO:0006464cellular protein modification process289
GO:2001244positive regulation of intrinsic apoptotic signaling pathway133
GO:0043537negative regulation of blood vessel endothelial cell migration113
GO:0043068positive regulation of programmed cell death18
GO:0006283transcription-coupled nucleotide-excision repair846
GO:0042127regulation of cell proliferation4111
GO:0007494midgut development19
GO:0006021inositol biosynthetic process13
GO:0017148negative regulation of translation141
GO:0005507copper ion binding248
GO:0033144negative regulation of intracellular steroid hormone receptor signaling pathway12
GO:0043125ErbB-3 class receptor binding14
GO:0044822poly(A) RNA binding501078
GO:0006323DNA packaging15
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity343
GO:0010628positive regulation of gene expression4149
GO:0035902response to immobilization stress117
GO:0002876positive regulation of chronic inflammatory response to antigenic stimulus12
GO:0008380RNA splicing13232
GO:0006983ER overload response29
GO:0005930axoneme141
GO:0045787positive regulation of cell cycle123
GO:0003723RNA binding19355
GO:0030690Noc1p-Noc2p complex11
GO:0022625cytosolic large ribosomal subunit549
GO:0005741mitochondrial outer membrane4108
GO:0032133chromosome passenger complex14
GO:2001237negative regulation of extrinsic apoptotic signaling pathway135
GO:0010165response to X-ray219
GO:00171085'-flap endonuclease activity15
GO:0061024membrane organization5146
GO:0009925basal plasma membrane129
GO:0050769positive regulation of neurogenesis119
GO:0045717negative regulation of fatty acid biosynthetic process19
GO:0048661positive regulation of smooth muscle cell proliferation249
GO:0005719nuclear euchromatin220
GO:0035024negative regulation of Rho protein signal transduction111
GO:0017081chloride channel regulator activity15
GO:0007098centrosome cycle14
GO:0004602glutathione peroxidase activity114
GO:0032715negative regulation of interleukin-6 production120
GO:2000036regulation of stem cell maintenance211
GO:0071363cellular response to growth factor stimulus242
GO:0055119relaxation of cardiac muscle112
GO:0046985positive regulation of hemoglobin biosynthetic process12
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex16
GO:0046686response to cadmium ion322
GO:0050764regulation of phagocytosis16
GO:0043691reverse cholesterol transport116
GO:0071285cellular response to lithium ion214
GO:0005827polar microtubule15
GO:0005643nuclear pore459
GO:0051534negative regulation of NFAT protein import into nucleus14
GO:0075713establishment of integrated proviral latency28
GO:0003674molecular_function1524
GO:0006511ubiquitin-dependent protein catabolic process5127
GO:0043967histone H4 acetylation328
GO:0045994positive regulation of translational initiation by iron11
GO:0043565sequence-specific DNA binding4365
GO:0050830defense response to Gram-positive bacterium149
GO:0051384response to glucocorticoid262
GO:0004075biotin carboxylase activity16
GO:0005098Ran GTPase activator activity11
GO:0007254JNK cascade251
GO:0034333adherens junction assembly17
GO:0006168adenine salvage13
GO:0032232negative regulation of actin filament bundle assembly14
GO:0070527platelet aggregation238
GO:0005726perichromatin fibrils13
GO:0006879cellular iron ion homeostasis557
GO:0004055argininosuccinate synthase activity11
GO:0003896DNA primase activity24
GO:0006725cellular aromatic compound metabolic process12
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway171
GO:0005838proteasome regulatory particle712
GO:0006687glycosphingolipid metabolic process138
GO:0006734NADH metabolic process15
GO:0044205'de novo' UMP biosynthetic process13
GO:0007015actin filament organization240
GO:0005515protein binding1726127
GO:0006959humoral immune response152
GO:0000777condensed chromosome kinetochore268
GO:0007411axon guidance9327
GO:0006936muscle contraction188
GO:0030670phagocytic vesicle membrane349
GO:0019682glyceraldehyde-3-phosphate metabolic process11
GO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway17
GO:0070129regulation of mitochondrial translation13
GO:0042765GPI-anchor transamidase complex15
GO:0070830tight junction assembly133
GO:0005811lipid particle151
GO:0004519endonuclease activity126
GO:0005657replication fork318
GO:0051897positive regulation of protein kinase B signaling175
GO:0032741positive regulation of interleukin-18 production13
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway164
GO:0019887protein kinase regulator activity24
GO:0042632cholesterol homeostasis153
GO:0005853eukaryotic translation elongation factor 1 complex24
GO:0071782endoplasmic reticulum tubular network14
GO:0036270response to diuretic11
GO:0045505dynein intermediate chain binding13
GO:0042572retinol metabolic process118
GO:0042581specific granule112
GO:0005123death receptor binding115
GO:0051604protein maturation110
GO:0022604regulation of cell morphogenesis117
GO:0005737cytoplasm983976
GO:0003407neural retina development15
GO:0033018sarcoplasmic reticulum lumen18
GO:0006914autophagy177
GO:0006006glucose metabolic process4119
GO:0042730fibrinolysis118
GO:0035749myelin sheath adaxonal region25
GO:0016581NuRD complex116
GO:0016055Wnt signaling pathway6141
GO:0070363mitochondrial light strand promoter sense binding12
GO:0033690positive regulation of osteoblast proliferation19
GO:1990239steroid hormone binding13
GO:0000287magnesium ion binding5174
GO:0005840ribosome259
GO:0097192extrinsic apoptotic signaling pathway in absence of ligand235
GO:0030307positive regulation of cell growth270
GO:0010988regulation of low-density lipoprotein particle clearance13
GO:0006754ATP biosynthetic process120
GO:0051010microtubule plus-end binding111
GO:0002740negative regulation of cytokine secretion involved in immune response15
GO:0010046response to mycotoxin12
GO:0000165MAPK cascade272
GO:0010243response to organonitrogen compound217
GO:0009750response to fructose13
GO:0005658alpha DNA polymerase:primase complex14
GO:0006853carnitine shuttle19
GO:0016925protein sumoylation127
GO:0030049muscle filament sliding138
GO:0002028regulation of sodium ion transport113
GO:0016023cytoplasmic membrane-bounded vesicle3107
GO:0016272prefoldin complex19
GO:0002576platelet degranulation482
GO:0006362transcription elongation from RNA polymerase I promoter323
GO:0007080mitotic metaphase plate congression113
GO:0007173epidermal growth factor receptor signaling pathway4191
GO:0004383guanylate cyclase activity18
GO:0042493response to drug11288
GO:0005834heterotrimeric G-protein complex134
GO:0043524negative regulation of neuron apoptotic process2119
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 protein15
GO:0008139nuclear localization sequence binding29
GO:0018119peptidyl-cysteine S-nitrosylation13
GO:0006474N-terminal protein amino acid acetylation16
GO:0006767water-soluble vitamin metabolic process375
GO:0006855drug transmembrane transport112
GO:0070588calcium ion transmembrane transport1106
GO:0006986response to unfolded protein251
GO:0032227negative regulation of synaptic transmission, dopaminergic12
GO:0001961positive regulation of cytokine-mediated signaling pathway17
GO:0045629negative regulation of T-helper 2 cell differentiation13
GO:0000028ribosomal small subunit assembly17
GO:0000413protein peptidyl-prolyl isomerization134
GO:0000737DNA catabolic process, endonucleolytic239
GO:0034138toll-like receptor 3 signaling pathway280
GO:00515383 iron, 4 sulfur cluster binding12
GO:0004820glycine-tRNA ligase activity11
GO:1900748positive regulation of vascular endothelial growth factor signaling pathway12
GO:0005666DNA-directed RNA polymerase III complex317
GO:0005802trans-Golgi network2116
GO:0008963phospho-N-acetylmuramoyl-pentapeptide-transferase activity11
GO:0031325positive regulation of cellular metabolic process18
GO:0030177positive regulation of Wnt signaling pathway328
GO:0007603phototransduction, visible light181
GO:1901525negative regulation of macromitophagy12
GO:0046513ceramide biosynthetic process116
GO:0006383transcription from RNA polymerase III promoter339
GO:0045842positive regulation of mitotic metaphase/anaphase transition16
GO:0007528neuromuscular junction development132
GO:0071316cellular response to nicotine18
GO:0051533positive regulation of NFAT protein import into nucleus14
GO:0060539diaphragm development18
GO:0008286insulin receptor signaling pathway6144
GO:0048011neurotrophin TRK receptor signaling pathway6273
GO:0007067mitotic nuclear division13231
GO:0006390transcription from mitochondrial promoter18
GO:0000792heterochromatin222
GO:0030968endoplasmic reticulum unfolded protein response281
GO:0046599regulation of centriole replication15
GO:0005885Arp2/3 protein complex17
GO:0035986senescence-associated heterochromatin focus assembly13
GO:0004149dihydrolipoyllysine-residue succinyltransferase activity11
GO:0004128cytochrome-b5 reductase activity, acting on NAD(P)H16
GO:0045010actin nucleation13
GO:0004596peptide alpha-N-acetyltransferase activity17
GO:0001764neuron migration296
GO:0006346methylation-dependent chromatin silencing16
GO:0010827regulation of glucose transport131
GO:0002176male germ cell proliferation12
GO:0042994cytoplasmic sequestering of transcription factor113
GO:0019395fatty acid oxidation111
GO:0016446somatic hypermutation of immunoglobulin genes19
GO:0005875microtubule associated complex228
GO:0005576extracellular region91049
GO:0005246calcium channel regulator activity118
GO:0045160myosin I complex11
GO:0008156negative regulation of DNA replication121
GO:0000722telomere maintenance via recombination726
GO:0000715nucleotide-excision repair, DNA damage recognition12
GO:0021860pyramidal neuron development16
GO:0032707negative regulation of interleukin-23 production12
GO:0042803protein homodimerization activity11617
GO:0035965cardiolipin acyl-chain remodeling15
GO:0004527exonuclease activity114
GO:0051082unfolded protein binding695
GO:0005905coated pit251
GO:0009615response to virus6132
GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulin15
GO:0000149SNARE binding118
GO:0060044negative regulation of cardiac muscle cell proliferation18
GO:0007214gamma-aminobutyric acid signaling pathway120
GO:0032479regulation of type I interferon production213
GO:0070182DNA polymerase binding28
GO:0001054RNA polymerase I activity311
GO:0000932cytoplasmic mRNA processing body356
GO:0030955potassium ion binding18
GO:0043023ribosomal large subunit binding26
GO:0051101regulation of DNA binding15
GO:0003700sequence-specific DNA binding transcription factor activity11748
GO:0001047core promoter binding246
GO:0033993response to lipid26
GO:0001867complement activation, lectin pathway17
GO:0051097negative regulation of helicase activity13
GO:0008622epsilon DNA polymerase complex15
GO:0042908xenobiotic transport15
GO:0097150neuronal stem cell maintenance113
GO:0043623cellular protein complex assembly116
GO:0007589body fluid secretion110
GO:0004634phosphopyruvate hydratase activity24
GO:0042092type 2 immune response14
GO:0035987endodermal cell differentiation126
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis17
GO:0016471vacuolar proton-transporting V-type ATPase complex18
GO:0048662negative regulation of smooth muscle cell proliferation128
GO:0002020protease binding474
GO:0007585respiratory gaseous exchange131
GO:0000187activation of MAPK activity490
GO:0090023positive regulation of neutrophil chemotaxis118
GO:0035518histone H2A monoubiquitination211
GO:0009986cell surface9422
GO:0003713transcription coactivator activity10239
GO:0000794condensed nuclear chromosome224
GO:0031466Cul5-RING ubiquitin ligase complex16
GO:0070419nonhomologous end joining complex16
GO:0019903protein phosphatase binding463
GO:0007166cell surface receptor signaling pathway1149
GO:0008584male gonad development277
GO:2000648positive regulation of stem cell proliferation110
GO:0007625grooming behavior112
GO:0016605PML body592
GO:0046965retinoid X receptor binding215
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process677
GO:0006690icosanoid metabolic process17
GO:0004018N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity11
GO:0006814sodium ion transport155
GO:0070557PCNA-p21 complex12
GO:0043388positive regulation of DNA binding124
GO:0044295axonal growth cone113
GO:0032700negative regulation of interleukin-17 production110
GO:0051023regulation of immunoglobulin secretion15
GO:0034080CENP-A containing nucleosome assembly227
GO:0001942hair follicle development235
GO:0045416positive regulation of interleukin-8 biosynthetic process18
GO:0010891negative regulation of sequestering of triglyceride15
GO:0071481cellular response to X-ray15
GO:0006275regulation of DNA replication212
GO:0055106ubiquitin-protein transferase regulator activity13
GO:0035877death effector domain binding14
GO:0031915positive regulation of synaptic plasticity15
GO:0051259protein oligomerization241
GO:0007368determination of left/right symmetry138
GO:0060336negative regulation of interferon-gamma-mediated signaling pathway15
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator230
GO:0045740positive regulation of DNA replication238
GO:0045296cadherin binding225
GO:0006182cGMP biosynthetic process115
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity126
GO:0030900forebrain development151
GO:0001953negative regulation of cell-matrix adhesion112
GO:0050885neuromuscular process controlling balance141
GO:0015074DNA integration18
GO:0043297apical junction assembly17
GO:0030331estrogen receptor binding227
GO:0006104succinyl-CoA metabolic process14
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle322
GO:0071407cellular response to organic cyclic compound239
GO:0006102isocitrate metabolic process15
GO:0045202synapse3140
GO:0045165cell fate commitment144
GO:0015909long-chain fatty acid transport17
GO:0005001transmembrane receptor protein tyrosine phosphatase activity118
GO:0004402histone acetyltransferase activity143
GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity136
GO:0048565digestive tract development127
GO:0001775cell activation17
GO:0043647inositol phosphate metabolic process142
GO:0007095mitotic G2 DNA damage checkpoint114
GO:0048365Rac GTPase binding229
GO:0000055ribosomal large subunit export from nucleus14
GO:0071499cellular response to laminar fluid shear stress17
GO:0090090negative regulation of canonical Wnt signaling pathway388
GO:0000961negative regulation of mitochondrial RNA catabolic process12
GO:0004998transferrin receptor activity12
GO:0003989acetyl-CoA carboxylase activity12
GO:0006363termination of RNA polymerase I transcription324
GO:0035729cellular response to hepatocyte growth factor stimulus17
GO:0005925focal adhesion18370
GO:0051660establishment of centrosome localization11
GO:0047497mitochondrion transport along microtubule29
GO:0051290protein heterotetramerization211
GO:0009107lipoate biosynthetic process12
GO:0035189Rb-E2F complex14
GO:0006487protein N-linked glycosylation122
GO:0009954proximal/distal pattern formation121
GO:0034088maintenance of mitotic sister chromatid cohesion14
GO:0030836positive regulation of actin filament depolymerization27
GO:0032369negative regulation of lipid transport14
GO:0030866cortical actin cytoskeleton organization119
GO:0007094mitotic spindle assembly checkpoint531
GO:0036353histone H2A-K119 monoubiquitination11
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor13
GO:00084083'-5' exonuclease activity216
GO:0000730DNA recombinase assembly35
GO:0060453regulation of gastric acid secretion11
GO:0051208sequestering of calcium ion14
GO:0006927transformed cell apoptotic process16
GO:0034684integrin alphav-beta5 complex12
GO:0005773vacuole17
GO:0005638lamin filament15
GO:0002467germinal center formation18
GO:0045444fat cell differentiation151
GO:0032201telomere maintenance via semi-conservative replication722
GO:0031966mitochondrial membrane159
GO:0000220vacuolar proton-transporting V-type ATPase, V0 domain14
GO:0000053argininosuccinate metabolic process11
GO:0071356cellular response to tumor necrosis factor160
GO:0035633maintenance of blood-brain barrier11
GO:0016874ligase activity1224
GO:0032405MutLalpha complex binding26
GO:0048730epidermis morphogenesis15
GO:0021540corpus callosum morphogenesis13
GO:0005815microtubule organizing center4110
GO:0071400cellular response to oleic acid13
GO:0015630microtubule cytoskeleton5112
GO:0051044positive regulation of membrane protein ectodomain proteolysis115
GO:0071542dopaminergic neuron differentiation113
GO:0001664G-protein coupled receptor binding138
GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine17
GO:0007052mitotic spindle organization222
GO:0055086nucleobase-containing small molecule metabolic process573
GO:0032321positive regulation of Rho GTPase activity188
GO:0030674protein binding, bridging152
GO:0022417protein maturation by protein folding19
GO:0006972hyperosmotic response19
GO:0051879Hsp90 protein binding117
GO:0000281mitotic cytokinesis221
GO:0033151V(D)J recombination19
GO:0090402oncogene-induced cell senescence12
GO:0006897endocytosis1108
GO:0030730sequestering of triglyceride13
GO:0001838embryonic epithelial tube formation12
GO:0007070negative regulation of transcription from RNA polymerase II promoter during mitosis22
GO:2000379positive regulation of reactive oxygen species metabolic process124
GO:0008469histone-arginine N-methyltransferase activity16
GO:0042626ATPase activity, coupled to transmembrane movement of substances128
GO:0048511rhythmic process247
GO:0007126meiotic nuclear division117
GO:0045943positive regulation of transcription from RNA polymerase I promoter16
GO:0050679positive regulation of epithelial cell proliferation154
GO:0032588trans-Golgi network membrane136
GO:0032091negative regulation of protein binding133
GO:0030858positive regulation of epithelial cell differentiation16
GO:0044183protein binding involved in protein folding19
GO:0002199zona pellucida receptor complex110
GO:0042110T cell activation343
GO:0055098response to low-density lipoprotein particle13
GO:0006094gluconeogenesis345
GO:0061574ASAP complex13
GO:0030027lamellipodium4130
GO:0043005neuron projection4161
GO:0007160cell-matrix adhesion388
GO:0034332adherens junction organization136
GO:0006606protein import into nucleus130
GO:0010693negative regulation of alkaline phosphatase activity14
GO:0045177apical part of cell182
GO:0006396RNA processing260
GO:0003688DNA replication origin binding16
GO:0007059chromosome segregation364
GO:0006521regulation of cellular amino acid metabolic process2150
GO:0050901leukocyte tethering or rolling115
GO:2000134negative regulation of G1/S transition of mitotic cell cycle220
GO:1900026positive regulation of substrate adhesion-dependent cell spreading223
GO:0001012RNA polymerase II regulatory region DNA binding13
GO:0007405neuroblast proliferation116
GO:0005975carbohydrate metabolic process5274
GO:0007026negative regulation of microtubule depolymerization116
GO:0006611protein export from nucleus425
GO:0097252oligodendrocyte apoptotic process12
GO:0008135translation factor activity, nucleic acid binding424
GO:0060384innervation113
GO:003068690S preribosome14
GO:0006953acute-phase response135
GO:0018467formaldehyde dehydrogenase activity11
GO:0006337nucleosome disassembly417
GO:0061136regulation of proteasomal protein catabolic process112
GO:0043021ribonucleoprotein complex binding121
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity347
GO:0005881cytoplasmic microtubule241
GO:0050660flavin adenine dinucleotide binding257
GO:0006259DNA metabolic process319
GO:0004722protein serine/threonine phosphatase activity142
GO:0005109frizzled binding132
GO:0035867alphav-beta3 integrin-IGF-1-IGF1R complex11
GO:0010310regulation of hydrogen peroxide metabolic process14
GO:0015030Cajal body245
GO:0021831embryonic olfactory bulb interneuron precursor migration12
GO:0016301kinase activity337
GO:0070979protein K11-linked ubiquitination326
GO:0045121membrane raft8161
GO:00709353'-UTR-mediated mRNA stabilization212
GO:1901379regulation of potassium ion transmembrane transport16
GO:0006099tricarboxylic acid cycle329
GO:0010033response to organic substance228
GO:0001618virus receptor activity130
GO:0032966negative regulation of collagen biosynthetic process15
GO:0001889liver development382
GO:0072659protein localization to plasma membrane141
GO:0001726ruffle482
GO:0006233dTDP biosynthetic process12
GO:0006644phospholipid metabolic process5137
GO:0007268synaptic transmission2353
GO:0060564negative regulation of mitotic anaphase-promoting complex activity13
GO:0002309T cell proliferation involved in immune response16
GO:0046856phosphatidylinositol dephosphorylation116
GO:0016020membrane801746
GO:0019788NEDD8 ligase activity14
GO:0006654phosphatidic acid biosynthetic process125
GO:0071383cellular response to steroid hormone stimulus110
GO:0009611response to wounding153
GO:0001652granular component14
GO:0050873brown fat cell differentiation231
GO:0016281eukaryotic translation initiation factor 4F complex19
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway136
GO:0010369chromocenter111
GO:0035887aortic smooth muscle cell differentiation12
GO:2000678negative regulation of transcription regulatory region DNA binding114
GO:0032693negative regulation of interleukin-10 production19
GO:0001882nucleoside binding15
GO:0003007heart morphogenesis134
GO:0003994aconitate hydratase activity12
GO:0001042RNA polymerase I core binding11
GO:0016328lateral plasma membrane246
GO:0006883cellular sodium ion homeostasis112
GO:0004766spermidine synthase activity12
GO:2000001regulation of DNA damage checkpoint15
GO:0043242negative regulation of protein complex disassembly14
GO:0016477cell migration6131
GO:0071459protein localization to chromosome, centromeric region13
GO:0071260cellular response to mechanical stimulus466
GO:0045786negative regulation of cell cycle141
GO:0047485protein N-terminus binding486
GO:0040008regulation of growth351
GO:0006302double-strand break repair862
GO:0035357peroxisome proliferator activated receptor signaling pathway14
GO:0045651positive regulation of macrophage differentiation211
GO:0071174mitotic spindle checkpoint14
GO:0045862positive regulation of proteolysis121
GO:0006468protein phosphorylation10467
GO:0090399replicative senescence110
GO:0043277apoptotic cell clearance114
GO:0033280response to vitamin D115
GO:0006886intracellular protein transport4173
GO:0008047enzyme activator activity139
GO:0090362positive regulation of platelet-derived growth factor production11
GO:0060041retina development in camera-type eye353
GO:0009952anterior/posterior pattern specification284
GO:0045116protein neddylation28
GO:0019941modification-dependent protein catabolic process15
GO:0010629negative regulation of gene expression180
GO:0007050cell cycle arrest7126
GO:0071320cellular response to cAMP142
GO:0007100mitotic centrosome separation14
GO:0031462Cul2-RING ubiquitin ligase complex27
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia226
GO:0042953lipoprotein transport112
GO:0030097hemopoiesis358
GO:1990268response to gold nanoparticle12
GO:0002439chronic inflammatory response to antigenic stimulus12
GO:0042483negative regulation of odontogenesis11
GO:0044297cell body246
GO:0046872metal ion binding241465
GO:0001948glycoprotein binding350
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2265
GO:0043101purine-containing compound salvage110
GO:0036148phosphatidylglycerol acyl-chain remodeling115
GO:0072369regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter12
GO:0045295gamma-catenin binding112
GO:0032481positive regulation of type I interferon production661
GO:0007596blood coagulation14464
GO:0016486peptide hormone processing116
GO:0030274LIM domain binding17
GO:0021987cerebral cortex development342
GO:0005736DNA-directed RNA polymerase I complex312
GO:0032800receptor biosynthetic process13
GO:0034446substrate adhesion-dependent cell spreading236
GO:0042802identical protein binding18491
GO:0006334nucleosome assembly479
GO:0006663platelet activating factor biosynthetic process14
GO:0007155cell adhesion8384
GO:0031201SNARE complex231
GO:0097284hepatocyte apoptotic process29
GO:0090385phagosome-lysosome fusion13
GO:0032733positive regulation of interleukin-10 production119
GO:0017091AU-rich element binding115
GO:0045773positive regulation of axon extension218
GO:0048168regulation of neuronal synaptic plasticity114
GO:0071242cellular response to ammonium ion12
GO:0005516calmodulin binding2162
GO:0031012extracellular matrix1158
GO:1903506regulation of nucleic acid-templated transcription119
GO:0004725protein tyrosine phosphatase activity280
GO:0006271DNA strand elongation involved in DNA replication931
GO:0071364cellular response to epidermal growth factor stimulus121
GO:0043130ubiquitin binding146
GO:0000086G2/M transition of mitotic cell cycle7137
GO:0010951negative regulation of endopeptidase activity1114
GO:0006661phosphatidylinositol biosynthetic process154
GO:0050860negative regulation of T cell receptor signaling pathway113
GO:0021794thalamus development112
GO:0036016cellular response to interleukin-315
GO:0048306calcium-dependent protein binding257
GO:0032729positive regulation of interferon-gamma production239
GO:0002326B cell lineage commitment14
GO:0030330DNA damage response, signal transduction by p53 class mediator114
GO:0016126sterol biosynthetic process26
GO:0048667cell morphogenesis involved in neuron differentiation15
GO:0005768endosome5174
GO:0001725stress fiber156
GO:0051171regulation of nitrogen compound metabolic process11
GO:0010389regulation of G2/M transition of mitotic cell cycle19
GO:2000077negative regulation of type B pancreatic cell development12
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent2373
GO:0001843neural tube closure275
GO:0005215transporter activity1145
GO:0044772mitotic cell cycle phase transition11
GO:0004982N-formyl peptide receptor activity12
GO:0051022Rho GDP-dissociation inhibitor binding12
GO:0005777peroxisome290
GO:0001741XY body112
GO:0031065positive regulation of histone deacetylation19
GO:0090230regulation of centromere complex assembly11
GO:0016829lyase activity115
GO:0086064cell communication by electrical coupling involved in cardiac conduction112
GO:0030838positive regulation of actin filament polymerization236
GO:0030155regulation of cell adhesion342
GO:0016407acetyltransferase activity110
GO:0072562blood microparticle4116
GO:0048538thymus development236
GO:0004807triose-phosphate isomerase activity11
GO:0051496positive regulation of stress fiber assembly239
GO:0006928cellular component movement792
GO:0034375high-density lipoprotein particle remodeling114
GO:0000723telomere maintenance859
GO:0006268DNA unwinding involved in DNA replication210
GO:0031402sodium ion binding15
GO:0042162telomeric DNA binding111
GO:0034113heterotypic cell-cell adhesion119
GO:2001238positive regulation of extrinsic apoptotic signaling pathway127
GO:0006457protein folding8149
GO:0006595polyamine metabolic process114
GO:0002931response to ischemia120
GO:0000793condensed chromosome121
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding5168
GO:0003729mRNA binding473
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity119
GO:0004622lysophospholipase activity114
GO:0032461positive regulation of protein oligomerization112
GO:0070245positive regulation of thymocyte apoptotic process16
GO:0009314response to radiation127
GO:0045596negative regulation of cell differentiation122
GO:0006412translation15235
GO:0009303rRNA transcription112
GO:0019322pentose biosynthetic process12
GO:0004222metalloendopeptidase activity186
GO:0030521androgen receptor signaling pathway241
GO:0030135coated vesicle13
GO:0006633fatty acid biosynthetic process237
GO:0030308negative regulation of cell growth6113
GO:0045214sarcomere organization126
GO:0043034costamere121
GO:0007613memory256
GO:0031492nucleosomal DNA binding428
GO:0031994insulin-like growth factor I binding17
GO:0034329cell junction assembly171
GO:0005874microtubule6258
GO:0031340positive regulation of vesicle fusion17
GO:0001973adenosine receptor signaling pathway19
GO:0043621protein self-association138
GO:0032411positive regulation of transporter activity15
GO:0015949nucleobase-containing small molecule interconversion218
GO:0016887ATPase activity7144
GO:0090004positive regulation of establishment of protein localization to plasma membrane122
GO:0019209kinase activator activity16
GO:0022624proteasome accessory complex917
GO:0021895cerebral cortex neuron differentiation19
GO:0006695cholesterol biosynthetic process234
GO:0003684damaged DNA binding1151
GO:0019827stem cell maintenance148
GO:0003755peptidyl-prolyl cis-trans isomerase activity134
GO:0004523RNA-DNA hybrid ribonuclease activity15
GO:0001757somite specification14
GO:0012505endomembrane system257
GO:0048593camera-type eye morphogenesis117
GO:0002102podosome217
GO:0006631fatty acid metabolic process145
GO:0002093auditory receptor cell morphogenesis12
GO:0016074snoRNA metabolic process11
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling130
GO:0046827positive regulation of protein export from nucleus213
GO:0004252serine-type endopeptidase activity2119
GO:0060664epithelial cell proliferation involved in salivary gland morphogenesis17
GO:0010212response to ionizing radiation143
GO:0040020regulation of meiosis16
GO:0000125PCAF complex16
GO:0043198dendritic shaft129
GO:0009948anterior/posterior axis specification215
GO:0008233peptidase activity355
GO:0030323respiratory tube development14
GO:0034683integrin alphav-beta3 complex12
GO:0004672protein kinase activity2178
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway243
GO:0042273ribosomal large subunit biogenesis413
GO:0033189response to vitamin A114
GO:0007097nuclear migration17
GO:0006386termination of RNA polymerase III transcription318
GO:0009953dorsal/ventral pattern formation132
GO:0051414response to cortisol15
GO:0010719negative regulation of epithelial to mesenchymal transition121
GO:0048146positive regulation of fibroblast proliferation244
GO:0043024ribosomal small subunit binding110
GO:0045599negative regulation of fat cell differentiation235
GO:0006098pentose-phosphate shunt311
GO:0007422peripheral nervous system development127
GO:0031465Cul4B-RING E3 ubiquitin ligase complex25
GO:0003691double-stranded telomeric DNA binding15
GO:0001954positive regulation of cell-matrix adhesion121
GO:0000791euchromatin16
GO:0005245voltage-gated calcium channel activity137
GO:0008074guanylate cyclase complex, soluble12
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)14
GO:0048699generation of neurons19
GO:0030496midbody4109
GO:0030337DNA polymerase processivity factor activity12
GO:0019897extrinsic component of plasma membrane220
GO:0015631tubulin binding129
GO:0019932second-messenger-mediated signaling15
GO:0008144drug binding166
GO:0006084acetyl-CoA metabolic process13
GO:0043086negative regulation of catalytic activity274
GO:0016461unconventional myosin complex17
GO:0005886plasma membrane382834
GO:0050776regulation of immune response179
GO:0000226microtubule cytoskeleton organization355
GO:0097153cysteine-type endopeptidase activity involved in apoptotic process15
GO:0014823response to activity132
GO:0050046lathosterol oxidase activity11
GO:0042147retrograde transport, endosome to Golgi342
GO:0009048dosage compensation by inactivation of X chromosome13
GO:0005902microvillus242
GO:0045665negative regulation of neuron differentiation246
GO:0090307spindle assembly involved in mitosis110
GO:0005509calcium ion binding8589
GO:0035145exon-exon junction complex219
GO:0000783nuclear telomere cap complex19
GO:0002755MyD88-dependent toll-like receptor signaling pathway280
GO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 production14
GO:0086013membrane repolarization during cardiac muscle cell action potential17
GO:0016324apical plasma membrane2224
GO:0043407negative regulation of MAP kinase activity134
GO:0097190apoptotic signaling pathway4116
GO:0001819positive regulation of cytokine production119
GO:0030864cortical actin cytoskeleton125
GO:0051968positive regulation of synaptic transmission, glutamatergic116
GO:0010906regulation of glucose metabolic process117
GO:0032051clathrin light chain binding14
GO:0006614SRP-dependent cotranslational protein targeting to membrane8104
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand215
GO:2000378negative regulation of reactive oxygen species metabolic process114
GO:2000048negative regulation of cell-cell adhesion mediated by cadherin14
GO:0010826negative regulation of centrosome duplication14
GO:0036462TRAIL-activated apoptotic signaling pathway13
GO:00063707-methylguanosine mRNA capping430
GO:0004438phosphatidylinositol-3-phosphatase activity18
GO:0006403RNA localization12
GO:0051924regulation of calcium ion transport122
GO:0007584response to nutrient372
GO:0004864protein phosphatase inhibitor activity125
GO:0043219lateral loop15
GO:0060559positive regulation of calcidiol 1-monooxygenase activity13
GO:0007520myoblast fusion116
GO:0048863stem cell differentiation119
GO:0006167AMP biosynthetic process14
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process376
GO:0006892post-Golgi vesicle-mediated transport244
GO:0034236protein kinase A catalytic subunit binding112
GO:0005665DNA-directed RNA polymerase II, core complex416
GO:0003148outflow tract septum morphogenesis114
GO:0006361transcription initiation from RNA polymerase I promoter326
GO:0045109intermediate filament organization111
GO:0015643toxic substance binding110
GO:0010569regulation of double-strand break repair via homologous recombination111
GO:0003743translation initiation factor activity449
GO:0005913cell-cell adherens junction229
GO:0001837epithelial to mesenchymal transition133
GO:0016580Sin3 complex112
GO:0060744mammary gland branching involved in thelarche16
GO:0035067negative regulation of histone acetylation18
GO:0006915apoptotic process34571
GO:0048469cell maturation139
GO:0032139dinucleotide insertion or deletion binding13
GO:0060070canonical Wnt signaling pathway375
GO:0000463maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)13
GO:0035794positive regulation of mitochondrial membrane permeability13
GO:0031571mitotic G1 DNA damage checkpoint311
GO:0048675axon extension121
GO:0014065phosphatidylinositol 3-kinase signaling122
GO:0043043peptide biosynthetic process15
GO:0009636response to toxic substance166
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding244
GO:0070688MLL5-L complex18
GO:0035066positive regulation of histone acetylation115
GO:0045989positive regulation of striated muscle contraction11
GO:0032927positive regulation of activin receptor signaling pathway16
GO:0008088axon cargo transport110
GO:0000972transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery11
GO:0006438valyl-tRNA aminoacylation12
GO:0042383sarcolemma371
GO:0090200positive regulation of release of cytochrome c from mitochondria122
GO:0050715positive regulation of cytokine secretion125
GO:0032722positive regulation of chemokine production116
GO:0008168methyltransferase activity152
GO:0010595positive regulation of endothelial cell migration138
GO:0070335aspartate binding11
GO:0010332response to gamma radiation229
GO:0004713protein tyrosine kinase activity282
GO:0006768biotin metabolic process110
GO:0071565nBAF complex212
GO:0051721protein phosphatase 2A binding118
GO:0071899negative regulation of estrogen receptor binding13
GO:0005546phosphatidylinositol-4,5-bisphosphate binding241
GO:0045760positive regulation of action potential17
GO:0030010establishment of cell polarity221
GO:0008015blood circulation140
GO:0035914skeletal muscle cell differentiation142
GO:0001939female pronucleus17
GO:0008494translation activator activity19
GO:0004767sphingomyelin phosphodiesterase activity17
GO:0046294formaldehyde catabolic process12
GO:0019221cytokine-mediated signaling pathway3230
GO:0045070positive regulation of viral genome replication117
GO:0048566embryonic digestive tract development114
GO:0008262importin-alpha export receptor activity11
GO:0008541proteasome regulatory particle, lid subcomplex11
GO:0005635nuclear envelope6116
GO:0006987activation of signaling protein activity involved in unfolded protein response262
GO:0006281DNA repair22264
GO:0050852T cell receptor signaling pathway288
GO:0001669acrosomal vesicle151
GO:0031023microtubule organizing center organization15
GO:0060081membrane hyperpolarization112
GO:0038095Fc-epsilon receptor signaling pathway7171
GO:0000022mitotic spindle elongation12
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic132
GO:0034504protein localization to nucleus230
GO:0071526semaphorin-plexin signaling pathway119
GO:0072300positive regulation of metanephric glomerulus development13
GO:0097371MDM2/MDM4 family protein binding15
GO:0045777positive regulation of blood pressure117
GO:0016773phosphotransferase activity, alcohol group as acceptor16
GO:0031625ubiquitin protein ligase binding13180
GO:0005850eukaryotic translation initiation factor 2 complex13
GO:0090403oxidative stress-induced premature senescence14
GO:0034696response to prostaglandin F12
GO:0060263regulation of respiratory burst14
GO:0004826phenylalanine-tRNA ligase activity14
GO:0060694regulation of cholesterol transporter activity11
GO:0015031protein transport4357
GO:0008285negative regulation of cell proliferation11367
GO:0006956complement activation133
GO:0043626PCNA complex11
GO:0003899DNA-directed RNA polymerase activity225
GO:0033490cholesterol biosynthetic process via lathosterol11
GO:0060715syncytiotrophoblast cell differentiation involved in labyrinthine layer development13
GO:0030157pancreatic juice secretion17
GO:0052565response to defense-related host nitric oxide production11
GO:2000810regulation of tight junction assembly19
GO:0004046aminoacylase activity14
GO:0006206pyrimidine nucleobase metabolic process224
GO:0016230sphingomyelin phosphodiesterase activator activity12
GO:0045840positive regulation of mitosis128
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway137
GO:0051903S-(hydroxymethyl)glutathione dehydrogenase activity11
GO:0007569cell aging225
GO:0030837negative regulation of actin filament polymerization19
GO:0043234protein complex17300
GO:0071677positive regulation of mononuclear cell migration13
GO:0032633interleukin-4 production12
GO:0001832blastocyst growth13
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation175
GO:0006338chromatin remodeling468
GO:0097191extrinsic apoptotic signaling pathway238
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription2151
GO:0070986left/right axis specification112
GO:0045604regulation of epidermal cell differentiation13
GO:0060326cell chemotaxis151
GO:0008207C21-steroid hormone metabolic process12
GO:0006309apoptotic DNA fragmentation117
GO:0090136epithelial cell-cell adhesion19
GO:0031529ruffle organization115
GO:0007565female pregnancy280
GO:0001046core promoter sequence-specific DNA binding128
GO:0000056ribosomal small subunit export from nucleus13
GO:0044354macropinosome13
GO:0007093mitotic cell cycle checkpoint231
GO:0030132clathrin coat of coated pit17
GO:1901030positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway18
GO:0006898receptor-mediated endocytosis286
GO:0007010cytoskeleton organization296
GO:0003678DNA helicase activity319
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand134
GO:0006543glutamine catabolic process14
GO:0030742GTP-dependent protein binding117
GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process154
GO:0004822isoleucine-tRNA ligase activity12
GO:0030334regulation of cell migration252
GO:0030007cellular potassium ion homeostasis19
GO:0004512inositol-3-phosphate synthase activity11
GO:0007017microtubule-based process328
GO:0042255ribosome assembly15
GO:0030182neuron differentiation177
GO:0055085transmembrane transport8514
GO:0003382epithelial cell morphogenesis19
GO:0090179planar cell polarity pathway involved in neural tube closure113
GO:0036149phosphatidylinositol acyl-chain remodeling113
GO:0002862negative regulation of inflammatory response to antigenic stimulus16
GO:0008295spermidine biosynthetic process12
GO:0045080positive regulation of chemokine biosynthetic process19
GO:0033600negative regulation of mammary gland epithelial cell proliferation15
GO:0046330positive regulation of JNK cascade155
GO:2000425regulation of apoptotic cell clearance11
GO:0034452dynactin binding16
GO:0016597amino acid binding120
GO:0001675acrosome assembly110
GO:0043197dendritic spine283
GO:0017137Rab GTPase binding278
GO:0000186activation of MAPKK activity154
GO:0035799ureter maturation14
GO:0010970microtubule-based transport11
GO:0001227RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription120
GO:0071300cellular response to retinoic acid256
GO:0007084mitotic nuclear envelope reassembly110
GO:0001673male germ cell nucleus116
GO:0004151dihydroorotase activity11
GO:00061032-oxoglutarate metabolic process116
GO:0045429positive regulation of nitric oxide biosynthetic process335
GO:0007167enzyme linked receptor protein signaling pathway19
GO:0034349glial cell apoptotic process14
GO:0005484SNAP receptor activity224
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator120
GO:0005212structural constituent of eye lens116
GO:0019834phospholipase A2 inhibitor activity14
GO:0097199cysteine-type endopeptidase activity involved in apoptotic signaling pathway12
GO:0005770late endosome194
GO:0031134sister chromatid biorientation12
GO:0008237metallopeptidase activity158
GO:0045713low-density lipoprotein particle receptor biosynthetic process11
GO:0001104RNA polymerase II transcription cofactor activity133
GO:0006415translational termination887
GO:0000054ribosomal subunit export from nucleus11
GO:0051258protein polymerization227
GO:0006469negative regulation of protein kinase activity265
GO:0034399nuclear periphery112
GO:0004601peroxidase activity119
GO:0050680negative regulation of epithelial cell proliferation154
GO:0050321tau-protein kinase activity112
GO:0021799cerebral cortex radially oriented cell migration18
GO:0005938cell cortex3109
GO:0030877beta-catenin destruction complex210
GO:0008344adult locomotory behavior147
GO:0000060protein import into nucleus, translocation424
GO:0030669clathrin-coated endocytic vesicle membrane129
GO:0097178ruffle assembly16
GO:0016602CCAAT-binding factor complex14
GO:00515394 iron, 4 sulfur cluster binding337
GO:0036151phosphatidylcholine acyl-chain remodeling122
GO:0030506ankyrin binding121
GO:0031663lipopolysaccharide-mediated signaling pathway129
GO:0005955calcineurin complex14
GO:0004869cysteine-type endopeptidase inhibitor activity127
GO:0007127meiosis I12
GO:0005884actin filament246
GO:0051775response to redox state110
GO:0060850regulation of transcription involved in cell fate commitment15
GO:0071439clathrin complex13
GO:0006501C-terminal protein lipidation127
GO:0031175neuron projection development175
GO:0051701interaction with host434
GO:0035372protein localization to microtubule18
GO:0005876spindle microtubule334
GO:0070409carbamoyl phosphate biosynthetic process12
GO:0016035zeta DNA polymerase complex12
GO:0006968cellular defense response156
GO:0004486methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity11
GO:0032025response to cobalt ion15
GO:0045732positive regulation of protein catabolic process451
GO:0005794Golgi apparatus14650
GO:0060347heart trabecula formation115
GO:0046469platelet activating factor metabolic process11