meta-int-snw-5714

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-52 tai-screen-luciferase 4.903 9.49e-27 2.11e-04 3.66e-04 9 6
int-snw-5714 tai-screen-luciferase 6.408 6.16e-138 2.88e-07 2.35e-03 16 13
reg-snw-55854 tai-screen-luciferase 4.880 1.80e-26 2.35e-04 4.05e-04 5 3
reg-snw-8394 tai-screen-luciferase 4.751 5.99e-25 4.27e-04 7.04e-04 5 3
reg-snw-5770 tai-screen-luciferase 4.418 2.91e-21 1.75e-03 2.57e-03 13 7
reg-snw-1964 tai-screen-luciferase 4.532 1.75e-22 1.10e-03 1.69e-03 7 6
reg-snw-1500 tai-screen-luciferase 4.226 2.77e-19 3.65e-03 4.98e-03 9 7
tai-screen-luciferase-meta-int-snw-5714 subnetwork

Genes (40)

Gene Symbol Entrez Gene ID Frequency tai-screen-luciferase gene score Best subnetwork score Degree Transcription factor List-Gonzales GI Tai-Hits
ZMAT1 84460 5-3.1824.75136TF--
RPS2 6187 16-3.2414.22613-Yes-
COPA 1314 48-9.3955.672340TFYesYes
EIF1AX 1964 14-3.0054.53243TFYes-
HSF1 3297 46-4.1795.027209TF-Yes
COPB2 9276 48-13.1689.06341-YesYes
CKAP5 9793 46-7.2145.672130TFYesYes
PTPN1 5770 102.0674.4181---
ZC3H15 55854 143.2694.88011---
RPS16 6217 38-5.4444.880205---
PSMD1 5707 16-3.6046.408113--Yes
EIF2S2 8894 31-4.3205.672103-Yes-
RPS11 6205 44-6.5887.555175-Yes-
RPS6 6194 44-5.6038.046217-Yes-
MRPS12 6183 35-5.4215.516341TFYes-
TLK2 11011 21-4.0115.67214---
GCN1L1 10985 10-2.9184.41843TF--
YBX1 4904 24-3.0335.516296TF--
RAN 5901 38-3.8094.325258-YesYes
COPB1 1315 39-6.2219.063118-YesYes
SERBP1 26135 35-4.6125.516106--Yes
CDC5L 988 34-3.4195.672155TF--
RPS24 6229 46-7.0348.389217-Yes-
PIP5K1A 8394 5-1.8204.75130---
RPS9 6203 45-7.1277.555140-Yes-
PES1 23481 162.9174.22691TF--
COPZ1 22818 48-8.3019.06313-YesYes
YEATS4 8089 14-4.4444.53218-YesYes
ATP6V1D 51382 30-4.1317.286149---
WDR46 9277 31-4.2904.226101TFYesYes
EIF2S3 1968 14-3.1444.53213-Yes-
RPS27A 6233 45-5.6318.389344-Yes-
PSMC6 5706 14-3.1696.408158---
PSMD8 5714 15-2.9164.418143---
PSMD3 5709 22-3.9356.408201TF-Yes
EIF3M 10480 184.4514.88055TFYes-
ACP1 52 8-2.2304.90346---
CTNND1 1500 16-2.6514.22653TFYes-
RPS26 6231 43-7.4788.04660-Yes-
ARCN1 372 48-8.2329.063118-YesYes

Interactions (101)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ARCN1 372 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
EIF2S2 8894 PES1 23481 pp -- int.I2D: YeastLow
PSMD1 5707 PSMD8 5714 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastMedium, Krogan_Core, MINT_Yeast
COPA 1314 PIP5K1A 8394 pd > reg.ITFP.txt: no annot
EIF2S2 8894 ATP6V1D 51382 pp -- int.I2D: YeastLow
COPA 1314 PSMD8 5714 pp -- int.I2D: YeastLow
PSMD1 5707 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, Krogan_Core
RPS6 6194 RPS26 6231 pp -- int.I2D: YeastLow
ARCN1 372 RAN 5901 pp -- int.I2D: YeastLow
YBX1 4904 RPS11 6205 pp -- int.Intact: MI:0914(association)
PSMD3 5709 PIP5K1A 8394 pd > reg.ITFP.txt: no annot
RPS27A 6233 GCN1L1 10985 pp -- int.I2D: YeastLow
EIF1AX 1964 RPS11 6205 pp -- int.I2D: YeastMedium
ACP1 52 MRPS12 6183 pd < reg.ITFP.txt: no annot
YBX1 4904 SERBP1 26135 pd > reg.ITFP.txt: no annot
RPS9 6203 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
EIF1AX 1964 EIF2S3 1968 pd > reg.ITFP.txt: no annot
RPS9 6203 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
MRPS12 6183 RPS2 6187 pp -- int.I2D: YeastMedium
RPS11 6205 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RAN 5901 RPS11 6205 pp -- int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, MINT_Worm, NON_CORE
RPS6 6194 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS2 6187 PES1 23481 pp -- int.I2D: IntAct_Yeast
EIF1AX 1964 RPS2 6187 pp -- int.I2D: YeastMedium
YBX1 4904 PTPN1 5770 pd > reg.TRANSFAC.txt: no annot
RPS2 6187 RPS9 6203 pp -- int.I2D: BIND_Yeast
RPS24 6229 PES1 23481 pp -- int.I2D: IntAct_Yeast
RPS11 6205 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
YBX1 4904 GCN1L1 10985 pd <> reg.ITFP.txt: no annot
RPS2 6187 EIF3M 10480 pd < reg.ITFP.txt: no annot
RPS16 6217 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
PSMC6 5706 PSMD8 5714 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
CTNND1 1500 PES1 23481 pd <> reg.ITFP.txt: no annot
PSMD3 5709 PSMD8 5714 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, IntAct_Yeast, INTEROLOG, Krogan_Core, YeastHigh
EIF1AX 1964 YEATS4 8089 pd > reg.ITFP.txt: no annot
YBX1 4904 PSMD8 5714 pd > reg.ITFP.txt: no annot
RAN 5901 GCN1L1 10985 pp -- int.I2D: YeastLow
EIF1AX 1964 RPS9 6203 pp -- int.I2D: YeastMedium
ACP1 52 EIF1AX 1964 pp -- int.I2D: YeastMedium
RPS6 6194 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS27A 6233 pp -- int.I2D: YeastLow
RAN 5901 RPS2 6187 pp -- int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, CORE_2, MINT_Worm
RPS6 6194 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
COPA 1314 COPB1 1315 pp -- int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
PSMD8 5714 MRPS12 6183 pd < reg.ITFP.txt: no annot
RPS24 6229 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
CDC5L 988 CKAP5 9793 pd <> reg.ITFP.txt: no annot
RPS16 6217 EIF3M 10480 pd < reg.ITFP.txt: no annot
RPS2 6187 RPS6 6194 pp -- int.I2D: BioGrid_Yeast
RAN 5901 WDR46 9277 pp -- int.I2D: YeastLow
PSMD8 5714 ATP6V1D 51382 pp -- int.I2D: YeastLow
ACP1 52 CDC5L 988 pd < reg.ITFP.txt: no annot
YBX1 4904 RPS24 6229 pp -- int.Intact: MI:0914(association)
WDR46 9277 PES1 23481 pd <> reg.ITFP.txt: no annot
COPA 1314 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
PSMC6 5706 RAN 5901 pp -- int.I2D: YeastLow
PSMC6 5706 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh
COPA 1314 COPB2 9276 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vivo
COPB1 1315 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium;
int.DIP: MI:0915(physical association)
EIF2S3 1968 PSMD3 5709 pp -- int.I2D: YeastLow
COPA 1314 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS2 6187 RPS11 6205 pp -- int.I2D: YeastMedium, INTEROLOG
RPS6 6194 EIF3M 10480 pd < reg.ITFP.txt: no annot
EIF1AX 1964 EIF2S2 8894 pp -- int.I2D: BioGrid_Yeast
CDC5L 988 TLK2 11011 pd > reg.ITFP.txt: no annot
HSF1 3297 MRPS12 6183 pd <> reg.ITFP.txt: no annot
CDC5L 988 YBX1 4904 pd <> reg.ITFP.txt: no annot
YBX1 4904 MRPS12 6183 pd <> reg.ITFP.txt: no annot
PIP5K1A 8394 ZMAT1 84460 pd < reg.ITFP.txt: no annot
CDC5L 988 GCN1L1 10985 pp -- int.I2D: BioGrid
CTNND1 1500 RPS2 6187 pd > reg.ITFP.txt: no annot
EIF1AX 1964 RPS16 6217 pp -- int.I2D: YeastMedium
RPS2 6187 RPS16 6217 pp -- int.I2D: INTEROLOG, YeastMedium, BioGrid_Yeast
CDC5L 988 COPA 1314 pd <> reg.ITFP.txt: no annot
CDC5L 988 EIF2S2 8894 pd > reg.ITFP.txt: no annot
EIF2S3 1968 ATP6V1D 51382 pp -- int.I2D: YeastLow
COPB1 1315 COPB2 9276 pp -- int.I2D: BioGrid
ARCN1 372 COPB1 1315 pp -- int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS;
int.HPRD: in vivo
RPS9 6203 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
EIF2S3 1968 GCN1L1 10985 pd < reg.ITFP.txt: no annot
PSMC6 5706 RPS27A 6233 pp -- int.I2D: YeastLow
ARCN1 372 COPA 1314 pp -- int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core;
int.HPRD: in vivo
EIF2S3 1968 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMC6 5706 PSMD1 5707 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid_Yeast, Krogan_Core, MINT_Yeast
EIF1AX 1964 EIF3M 10480 pd <> reg.ITFP.txt: no annot
EIF3M 10480 ZC3H15 55854 pd > reg.ITFP.txt: no annot
CDC5L 988 RPS16 6217 pp -- int.I2D: BioGrid
COPA 1314 RPS27A 6233 pp -- int.I2D: YeastLow
RPS16 6217 RPS26 6231 pp -- int.I2D: BioGrid_Yeast
RAN 5901 ATP6V1D 51382 pp -- int.I2D: YeastLow
ARCN1 372 COPB2 9276 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vivo
RAN 5901 PES1 23481 pd < reg.ITFP.txt: no annot
EIF2S3 1968 EIF2S2 8894 pp -- int.Intact: MI:0407(direct interaction);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, MINT_Yeast, YeastHigh, Yu_GoldStd
PSMD3 5709 GCN1L1 10985 pd <> reg.ITFP.txt: no annot
RPS6 6194 PES1 23481 pp -- int.I2D: IntAct_Yeast
PSMC6 5706 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS24 6229 RPS27A 6233 pp -- int.I2D: YeastMedium
RPS27A 6233 EIF3M 10480 pd < reg.ITFP.txt: no annot
PSMD3 5709 MRPS12 6183 pd <> reg.ITFP.txt: no annot

Related GO terms (364)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0006413translational initiation1.97e-163.22e-125.2241227131
GO:0044822poly(A) RNA binding5.36e-158.75e-112.99121421078
GO:0006412translation6.99e-151.14e-104.4961329235
GO:0022627cytosolic small ribosomal subunit3.60e-145.87e-106.38782139
GO:0010467gene expression7.83e-141.28e-093.3741736669
GO:0016071mRNA metabolic process1.26e-132.05e-094.4571229223
GO:0016070RNA metabolic process4.24e-136.92e-094.3091229247
GO:0015935small ribosomal subunit1.78e-122.90e-087.1706917
GO:0005829cytosol2.66e-124.34e-082.05026742562
GO:0019058viral life cycle7.10e-121.16e-074.997925115
GO:0016032viral process1.68e-112.74e-073.4031437540
GO:0019083viral transcription1.75e-112.85e-075.33382281
GO:0006415translational termination3.14e-115.13e-075.23082287
GO:0003735structural constituent of ribosome4.51e-117.37e-074.703924141
GO:0006414translational elongation5.42e-118.84e-075.13382293
GO:0016020membrane6.45e-111.05e-062.29521481746
GO:0048205COPI coating of Golgi vesicle8.66e-111.41e-067.2945613
GO:0030126COPI vesicle coat8.66e-111.41e-067.2945613
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.34e-102.19e-064.972822104
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay2.82e-104.60e-064.840822114
GO:0006890retrograde vesicle-mediated transport, Golgi to ER3.50e-095.71e-056.3515625
GO:0044267cellular protein metabolic process1.86e-083.04e-043.1811129495
GO:0022624proteasome accessory complex7.19e-081.17e-036.5854417
GO:0008135translation factor activity, nucleic acid binding3.17e-075.18e-036.0884424
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.06e-078.26e-034.9725665
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest5.06e-078.26e-034.9725665
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.35e-071.20e-024.8655870
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent9.07e-071.48e-024.8055673
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle9.71e-071.59e-024.7855874
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.19e-061.93e-024.7285677
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.35e-062.20e-024.6915879
GO:0061024membrane organization1.38e-062.25e-024.068611146
GO:0000082G1/S transition of mitotic cell cycle1.62e-062.64e-024.029611150
GO:0042981regulation of apoptotic process1.68e-062.74e-024.01967151
GO:0042274ribosomal small subunit biogenesis2.95e-064.82e-026.6733612
GO:0005838proteasome regulatory particle2.95e-064.82e-026.6733312
GO:0002474antigen processing and presentation of peptide antigen via MHC class I3.19e-065.21e-024.4405794
GO:0003743translation initiation factor activity6.05e-069.88e-025.0584549
GO:0006521regulation of cellular amino acid metabolic process6.57e-061.07e-015.0294550
GO:0070062extracellular vesicular exosome8.41e-061.37e-011.54618512516
GO:0000209protein polyubiquitination8.97e-061.46e-014.13657116
GO:0006891intra-Golgi vesicle-mediated transport9.06e-061.48e-016.1703317
GO:0000502proteasome complex1.19e-051.95e-014.8154458
GO:0005515protein binding3.09e-055.05e-010.89928876127
GO:0006886intracellular protein transport6.15e-051.00e+003.56056173
GO:0006364rRNA processing8.73e-051.00e+004.0884896
GO:0005654nucleoplasm2.35e-041.00e+001.89810261095
GO:0000278mitotic cell cycle3.85e-041.00e+002.621616398
GO:0005840ribosome4.03e-041.00e+004.37531059
GO:0030234enzyme regulator activity4.49e-041.00e+005.9722213
GO:0005730nucleolus4.98e-041.00e+001.54012361684
GO:0043066negative regulation of apoptotic process6.02e-041.00e+002.499614433
GO:0031369translation initiation factor binding6.03e-041.00e+005.7662215
GO:0042176regulation of protein catabolic process6.88e-041.00e+005.6732416
GO:0075733intracellular transport of virus7.78e-041.00e+005.5852317
GO:0034641cellular nitrogen compound metabolic process9.01e-041.00e+003.20545177
GO:0005737cytoplasm1.21e-031.00e+000.96319653976
GO:0019843rRNA binding1.98e-031.00e+004.9182427
GO:0005925focal adhesion2.00e-031.00e+002.463523370
GO:0007067mitotic nuclear division2.40e-031.00e+002.82147231
GO:0022605oogenesis stage2.45e-031.00e+008.673111
GO:0033176proton-transporting V-type ATPase complex2.45e-031.00e+008.673111
GO:0002183cytoplasmic translational initiation2.45e-031.00e+008.673111
GO:0021691cerebellar Purkinje cell layer maturation2.45e-031.00e+008.673111
GO:1990264peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity2.45e-031.00e+008.673111
GO:0030529ribonucleoprotein complex2.72e-031.00e+003.42538114
GO:0031532actin cytoskeleton reorganization4.74e-031.00e+004.2802242
GO:0071987WD40-repeat domain binding4.90e-031.00e+007.673112
GO:0002176male germ cell proliferation4.90e-031.00e+007.673112
GO:0000466maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)4.90e-031.00e+007.673112
GO:0072422signal transduction involved in DNA damage checkpoint4.90e-031.00e+007.673112
GO:0001672regulation of chromatin assembly or disassembly4.90e-031.00e+007.673112
GO:0035791platelet-derived growth factor receptor-beta signaling pathway4.90e-031.00e+007.673112
GO:0006650glycerophospholipid metabolic process4.90e-031.00e+007.673112
GO:1902202regulation of hepatocyte growth factor receptor signaling pathway4.90e-031.00e+007.673112
GO:0008286insulin receptor signaling pathway5.23e-031.00e+003.08834144
GO:0005198structural molecule activity6.88e-031.00e+002.94535159
GO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding7.33e-031.00e+007.088113
GO:0070545PeBoW complex7.33e-031.00e+007.088113
GO:0000463maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)7.33e-031.00e+007.088113
GO:0030951establishment or maintenance of microtubule cytoskeleton polarity7.33e-031.00e+007.088113
GO:0005850eukaryotic translation initiation factor 2 complex7.33e-031.00e+007.088113
GO:0051154negative regulation of striated muscle cell differentiation7.33e-031.00e+007.088113
GO:0000056ribosomal small subunit export from nucleus7.33e-031.00e+007.088123
GO:0097443sorting endosome7.33e-031.00e+007.088113
GO:0030687preribosome, large subunit precursor7.33e-031.00e+007.088113
GO:0007000nucleolus organization9.77e-031.00e+006.673124
GO:0000055ribosomal large subunit export from nucleus9.77e-031.00e+006.673114
GO:0090231regulation of spindle checkpoint9.77e-031.00e+006.673114
GO:0006417regulation of translation1.04e-021.00e+003.6952463
GO:0070934CRD-mediated mRNA stabilization1.22e-021.00e+006.351115
GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.22e-021.00e+006.351135
GO:0033119negative regulation of RNA splicing1.22e-021.00e+006.351125
GO:0006915apoptotic process1.23e-021.00e+001.83759571
GO:0003729mRNA binding1.38e-021.00e+003.4832373
GO:0007143female meiotic division1.46e-021.00e+006.088116
GO:0002309T cell proliferation involved in immune response1.46e-021.00e+006.088116
GO:0045182translation regulator activity1.46e-021.00e+006.088126
GO:0070937CRD-mediated mRNA stability complex1.46e-021.00e+006.088116
GO:0000974Prp19 complex1.46e-021.00e+006.088116
GO:0051347positive regulation of transferase activity1.46e-021.00e+006.088116
GO:0071204histone pre-mRNA 3'end processing complex1.46e-021.00e+006.088116
GO:0097178ruffle assembly1.46e-021.00e+006.088116
GO:0006924activation-induced cell death of T cells1.46e-021.00e+006.088126
GO:0050658RNA transport1.70e-021.00e+005.865117
GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activity1.70e-021.00e+005.865117
GO:0061512protein localization to cilium1.70e-021.00e+005.865117
GO:0000028ribosomal small subunit assembly1.70e-021.00e+005.865137
GO:0034101erythrocyte homeostasis1.70e-021.00e+005.865117
GO:0004726non-membrane spanning protein tyrosine phosphatase activity1.70e-021.00e+005.865117
GO:0030157pancreatic juice secretion1.70e-021.00e+005.865117
GO:0060136embryonic process involved in female pregnancy1.70e-021.00e+005.865117
GO:0071541eukaryotic translation initiation factor 3 complex, eIF3m1.70e-021.00e+005.865117
GO:0030948negative regulation of vascular endothelial growth factor receptor signaling pathway1.70e-021.00e+005.865117
GO:0000930gamma-tubulin complex1.70e-021.00e+005.865117
GO:0019221cytokine-mediated signaling pathway1.86e-021.00e+002.41235230
GO:0010761fibroblast migration1.94e-021.00e+005.673118
GO:0003993acid phosphatase activity1.94e-021.00e+005.673118
GO:0005847mRNA cleavage and polyadenylation specificity factor complex2.18e-021.00e+005.503119
GO:0005915zonula adherens2.18e-021.00e+005.503119
GO:0035335peptidyl-tyrosine dephosphorylation2.22e-021.00e+003.1182294
GO:0032863activation of Rac GTPase activity2.42e-021.00e+005.3511110
GO:0005798Golgi-associated vesicle2.42e-021.00e+005.3511110
GO:0045120pronucleus2.66e-021.00e+005.2131111
GO:0007051spindle organization2.90e-021.00e+005.0881112
GO:0043968histone H2A acetylation2.90e-021.00e+005.0881112
GO:0019082viral protein processing2.90e-021.00e+005.0881212
GO:0042273ribosomal large subunit biogenesis3.14e-021.00e+004.9721113
GO:0031929TOR signaling3.14e-021.00e+004.9721113
GO:0032479regulation of type I interferon production3.14e-021.00e+004.9721213
GO:0043488regulation of mRNA stability3.14e-021.00e+004.9721113
GO:0005662DNA replication factor A complex3.14e-021.00e+004.9721113
GO:0033290eukaryotic 48S preinitiation complex3.14e-021.00e+004.9721113
GO:0035371microtubule plus-end3.38e-021.00e+004.8651114
GO:0035267NuA4 histone acetyltransferase complex3.38e-021.00e+004.8651214
GO:0071480cellular response to gamma radiation3.38e-021.00e+004.8651114
GO:0016282eukaryotic 43S preinitiation complex3.38e-021.00e+004.8651114
GO:0044281small molecule metabolic process3.60e-021.00e+001.1417161295
GO:0048821erythrocyte development3.62e-021.00e+004.7661215
GO:0005852eukaryotic translation initiation factor 3 complex3.62e-021.00e+004.7661115
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process3.62e-021.00e+004.7661115
GO:0008654phospholipid biosynthetic process3.62e-021.00e+004.7661115
GO:0030131clathrin adaptor complex3.62e-021.00e+004.7661115
GO:0060334regulation of interferon-gamma-mediated signaling pathway3.85e-021.00e+004.6731116
GO:0030027lamellipodium4.03e-021.00e+002.65023130
GO:0033365protein localization to organelle4.09e-021.00e+004.5851117
GO:0009966regulation of signal transduction4.09e-021.00e+004.5851117
GO:0001731formation of translation preinitiation complex4.09e-021.00e+004.5851117
GO:0019068virion assembly4.09e-021.00e+004.5851217
GO:0030100regulation of endocytosis4.32e-021.00e+004.5031118
GO:0010507negative regulation of autophagy4.32e-021.00e+004.5031118
GO:0019901protein kinase binding4.33e-021.00e+001.93639320
GO:0000086G2/M transition of mitotic cell cycle4.43e-021.00e+002.57426137
GO:0006259DNA metabolic process4.56e-021.00e+004.4251119
GO:0072661protein targeting to plasma membrane4.56e-021.00e+004.4251119
GO:0017134fibroblast growth factor binding4.56e-021.00e+004.4251219
GO:0043231intracellular membrane-bounded organelle4.74e-021.00e+001.88233332
GO:0043473pigmentation4.79e-021.00e+004.3511220
GO:0003682chromatin binding4.81e-021.00e+001.87434334
GO:0043021ribonucleoprotein complex binding5.03e-021.00e+004.2801121
GO:0007369gastrulation5.03e-021.00e+004.2801121
GO:0000793condensed chromosome5.03e-021.00e+004.2801221
GO:0005689U12-type spliceosomal complex5.03e-021.00e+004.2801221
GO:0007220Notch receptor processing5.26e-021.00e+004.2131222
GO:0036464cytoplasmic ribonucleoprotein granule5.26e-021.00e+004.2131522
GO:0007052mitotic spindle organization5.26e-021.00e+004.2131122
GO:0001892embryonic placenta development5.49e-021.00e+004.1491123
GO:0051297centrosome organization5.49e-021.00e+004.1491223
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway5.49e-021.00e+004.1491123
GO:0048041focal adhesion assembly5.49e-021.00e+004.1491123
GO:0003723RNA binding5.58e-021.00e+001.786310355
GO:0005634nucleus5.60e-021.00e+000.52317664828
GO:0005761mitochondrial ribosome5.72e-021.00e+004.0881124
GO:0006611protein export from nucleus5.95e-021.00e+004.0291125
GO:0046627negative regulation of insulin receptor signaling pathway5.95e-021.00e+004.0291125
GO:0060338regulation of type I interferon-mediated signaling pathway5.95e-021.00e+004.0291125
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway5.95e-021.00e+004.0291225
GO:0005844polysome5.95e-021.00e+004.0291225
GO:0045296cadherin binding5.95e-021.00e+004.0291125
GO:0000398mRNA splicing, via spliceosome6.17e-021.00e+002.30622165
GO:0005978glycogen biosynthetic process6.19e-021.00e+003.9721226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia6.19e-021.00e+003.9721226
GO:0032720negative regulation of tumor necrosis factor production6.42e-021.00e+003.9181127
GO:0046854phosphatidylinositol phosphorylation6.65e-021.00e+003.8651128
GO:0043967histone H4 acetylation6.65e-021.00e+003.8651228
GO:0042626ATPase activity, coupled to transmembrane movement of substances6.65e-021.00e+003.8651128
GO:0016607nuclear speck6.84e-021.00e+002.22122175
GO:0003730mRNA 3'-UTR binding6.87e-021.00e+003.8151129
GO:0034605cellular response to heat6.87e-021.00e+003.8151129
GO:0040018positive regulation of multicellular organism growth7.10e-021.00e+003.7661130
GO:0046875ephrin receptor binding7.10e-021.00e+003.7661230
GO:0010494cytoplasmic stress granule7.10e-021.00e+003.7661230
GO:0070373negative regulation of ERK1 and ERK2 cascade7.33e-021.00e+003.7181131
GO:0007093mitotic cell cycle checkpoint7.33e-021.00e+003.7181231
GO:0006909phagocytosis7.33e-021.00e+003.7181131
GO:0015992proton transport7.56e-021.00e+003.6731132
GO:0032480negative regulation of type I interferon production7.56e-021.00e+003.6731232
GO:0033572transferrin transport7.56e-021.00e+003.6731132
GO:0030971receptor tyrosine kinase binding7.79e-021.00e+003.6281133
GO:0033077T cell differentiation in thymus7.79e-021.00e+003.6281133
GO:0005158insulin receptor binding7.79e-021.00e+003.6281233
GO:0001890placenta development8.01e-021.00e+003.5851134
GO:0051701interaction with host8.01e-021.00e+003.5851134
GO:0034332adherens junction organization8.46e-021.00e+003.5031436
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway8.46e-021.00e+003.5031336
GO:0006446regulation of translational initiation8.46e-021.00e+003.5031236
GO:0003924GTPase activity8.83e-021.00e+002.00726203
GO:0050681androgen receptor binding8.91e-021.00e+003.4251238
GO:0090382phagosome maturation8.91e-021.00e+003.4251138
GO:0051781positive regulation of cell division9.14e-021.00e+003.3871139
GO:0032092positive regulation of protein binding9.14e-021.00e+003.3871139
GO:0001701in utero embryonic development9.35e-021.00e+001.95822210
GO:0007249I-kappaB kinase/NF-kappaB signaling9.58e-021.00e+003.3151441
GO:0030521androgen receptor signaling pathway9.58e-021.00e+003.3151341
GO:0009898cytoplasmic side of plasma membrane9.80e-021.00e+003.2801142
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway1.00e-011.00e+003.2461243
GO:0006184GTP catabolic process1.01e-011.00e+001.89126220
GO:0007286spermatid development1.02e-011.00e+003.2131144
GO:0044297cell body1.07e-011.00e+003.1491146
GO:0030216keratinocyte differentiation1.09e-011.00e+003.1181147
GO:0008344adult locomotory behavior1.09e-011.00e+003.1181247
GO:0019003GDP binding1.11e-011.00e+003.0881148
GO:0040008regulation of growth1.18e-011.00e+003.0001151
GO:0060326cell chemotaxis1.18e-011.00e+003.0001151
GO:0007254JNK cascade1.18e-011.00e+003.0001351
GO:0030674protein binding, bridging1.20e-011.00e+002.9721152
GO:0006952defense response1.22e-011.00e+002.9451153
GO:0030666endocytic vesicle membrane1.24e-011.00e+002.9181254
GO:0019900kinase binding1.24e-011.00e+002.9181354
GO:0006661phosphatidylinositol biosynthetic process1.24e-011.00e+002.9181154
GO:0051403stress-activated MAPK cascade1.24e-011.00e+002.9181454
GO:0005793endoplasmic reticulum-Golgi intermediate compartment1.31e-011.00e+002.8401157
GO:0006879cellular iron ion homeostasis1.31e-011.00e+002.8401257
GO:0016197endosomal transport1.33e-011.00e+002.8151358
GO:0045216cell-cell junction organization1.35e-011.00e+002.7901259
GO:0005643nuclear pore1.35e-011.00e+002.7901159
GO:0048471perinuclear region of cytoplasm1.36e-011.00e+001.22739523
GO:0032481positive regulation of type I interferon production1.39e-011.00e+002.7421361
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription1.41e-011.00e+002.7181162
GO:0060337type I interferon signaling pathway1.43e-011.00e+002.6951163
GO:0043065positive regulation of apoptotic process1.45e-011.00e+001.57426274
GO:0007059chromosome segregation1.46e-011.00e+002.6731364
GO:0060333interferon-gamma-mediated signaling pathway1.46e-011.00e+002.6731164
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway1.46e-011.00e+002.6731264
GO:0034166toll-like receptor 10 signaling pathway1.48e-011.00e+002.6501565
GO:0034146toll-like receptor 5 signaling pathway1.48e-011.00e+002.6501565
GO:0005882intermediate filament1.50e-011.00e+002.6281366
GO:0003697single-stranded DNA binding1.56e-011.00e+002.5641469
GO:0018105peptidyl-serine phosphorylation1.56e-011.00e+002.5641569
GO:0019899enzyme binding1.57e-011.00e+001.50325288
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway1.60e-011.00e+002.5231571
GO:0034329cell junction assembly1.60e-011.00e+002.5231271
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway1.60e-011.00e+002.5231571
GO:0034162toll-like receptor 9 signaling pathway1.62e-011.00e+002.5031572
GO:0032587ruffle membrane1.62e-011.00e+002.5031172
GO:0034134toll-like receptor 2 signaling pathway1.64e-011.00e+002.4831573
GO:0000785chromatin1.64e-011.00e+002.4831273
GO:0043234protein complex1.67e-011.00e+001.44429300
GO:0035666TRIF-dependent toll-like receptor signaling pathway1.70e-011.00e+002.4251576
GO:0008584male gonad development1.73e-011.00e+002.4061177
GO:0000122negative regulation of transcription from RNA polymerase II promoter1.74e-011.00e+001.05539589
GO:0002756MyD88-independent toll-like receptor signaling pathway1.75e-011.00e+002.3871578
GO:0071013catalytic step 2 spliceosome1.77e-011.00e+002.3691179
GO:0002755MyD88-dependent toll-like receptor signaling pathway1.79e-011.00e+002.3511580
GO:0034138toll-like receptor 3 signaling pathway1.79e-011.00e+002.3511580
GO:0004725protein tyrosine phosphatase activity1.79e-011.00e+002.3511180
GO:0030968endoplasmic reticulum unfolded protein response1.81e-011.00e+002.3331181
GO:0043197dendritic spine1.85e-011.00e+002.2971283
GO:0005179hormone activity1.87e-011.00e+002.2801184
GO:0005929cilium1.87e-011.00e+002.2801284
GO:0005525GTP binding1.92e-011.00e+001.31526328
GO:0050852T cell receptor signaling pathway1.95e-011.00e+002.2131288
GO:0090090negative regulation of canonical Wnt signaling pathway1.95e-011.00e+002.2131388
GO:0042593glucose homeostasis1.97e-011.00e+002.1971189
GO:0000187activation of MAPK activity1.99e-011.00e+002.1811390
GO:0042384cilium assembly1.99e-011.00e+002.1811290
GO:0000922spindle pole2.01e-011.00e+002.1651591
GO:0003690double-stranded DNA binding2.01e-011.00e+002.1651291
GO:0005813centrosome2.02e-011.00e+001.26729339
GO:0016363nuclear matrix2.03e-011.00e+002.1491492
GO:0016337single organismal cell-cell adhesion2.03e-011.00e+002.1491292
GO:0042470melanosome2.03e-011.00e+002.1491292
GO:0005200structural constituent of cytoskeleton2.05e-011.00e+002.1331693
GO:0001649osteoblast differentiation2.08e-011.00e+002.1031395
GO:0034142toll-like receptor 4 signaling pathway2.10e-011.00e+002.0881596
GO:0030426growth cone2.12e-011.00e+002.0731397
GO:0071456cellular response to hypoxia2.14e-011.00e+002.0581398
GO:0016568chromatin modification2.16e-011.00e+002.0431299
GO:0051726regulation of cell cycle2.22e-011.00e+002.00012102
GO:0030496midbody2.35e-011.00e+001.90414109
GO:0002224toll-like receptor signaling pathway2.35e-011.00e+001.90415109
GO:0031410cytoplasmic vesicle2.37e-011.00e+001.89111110
GO:0015630microtubule cytoskeleton2.41e-011.00e+001.86514112
GO:0097190apoptotic signaling pathway2.48e-011.00e+001.81513116
GO:0006006glucose metabolic process2.54e-011.00e+001.77814119
GO:0032496response to lipopolysaccharide2.60e-011.00e+001.74211122
GO:0006325chromatin organization2.61e-011.00e+001.73012123
GO:0051092positive regulation of NF-kappaB transcription factor activity2.65e-011.00e+001.70713125
GO:0007219Notch signaling pathway2.65e-011.00e+001.70714125
GO:0006511ubiquitin-dependent protein catabolic process2.69e-011.00e+001.68413127
GO:0007179transforming growth factor beta receptor signaling pathway2.74e-011.00e+001.65014130
GO:0016477cell migration2.76e-011.00e+001.63911131
GO:0003700sequence-specific DNA binding transcription factor activity2.77e-011.00e+000.71139748
GO:0006644phospholipid metabolic process2.87e-011.00e+001.57413137
GO:0045202synapse2.92e-011.00e+001.54311140
GO:0016055Wnt signaling pathway2.94e-011.00e+001.53313141
GO:0005911cell-cell junction2.95e-011.00e+001.52312142
GO:0016887ATPase activity2.99e-011.00e+001.50311144
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling3.06e-011.00e+001.46313148
GO:0006468protein phosphorylation3.18e-011.00e+000.80526467
GO:0010008endosome membrane3.21e-011.00e+001.37812157
GO:0005769early endosome3.23e-011.00e+001.36911158
GO:0006974cellular response to DNA damage stimulus3.23e-011.00e+001.36913158
GO:0008543fibroblast growth factor receptor signaling pathway3.24e-011.00e+001.36013159
GO:0008022protein C-terminus binding3.28e-011.00e+001.34214161
GO:0045893positive regulation of transcription, DNA-templated3.36e-011.00e+000.74528487
GO:0034220ion transmembrane transport3.38e-011.00e+001.28912167
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding3.39e-011.00e+001.28014168
GO:0038095Fc-epsilon receptor signaling pathway3.44e-011.00e+001.25513171
GO:0007420brain development3.46e-011.00e+001.24613172
GO:0006351transcription, DNA-templated3.47e-011.00e+000.3645171585
GO:0031965nuclear membrane3.52e-011.00e+001.21312176
GO:0007049cell cycle3.54e-011.00e+001.20514177
GO:0019904protein domain specific binding3.60e-011.00e+001.17313181
GO:0055085transmembrane transport3.60e-011.00e+000.66723514
GO:0006367transcription initiation from RNA polymerase II promoter3.65e-011.00e+001.14915184
GO:0007173epidermal growth factor receptor signaling pathway3.76e-011.00e+001.09515191
GO:0030168platelet activation3.97e-011.00e+000.99314205
GO:0005765lysosomal membrane4.16e-011.00e+000.90412218
GO:0003677DNA binding4.25e-011.00e+000.2734141351
GO:0008380RNA splicing4.36e-011.00e+000.81515232
GO:0005783endoplasmic reticulum4.44e-011.00e+000.42026610
GO:0003713transcription coactivator activity4.46e-011.00e+000.77216239
GO:0030425dendrite4.47e-011.00e+000.76613240
GO:0005794Golgi apparatus4.77e-011.00e+000.32828650
GO:0006281DNA repair4.80e-011.00e+000.62815264
GO:0005102receptor binding4.85e-011.00e+000.60612268
GO:0000166nucleotide binding4.90e-011.00e+000.58512272
GO:0048011neurotrophin TRK receptor signaling pathway4.91e-011.00e+000.58015273
GO:0005975carbohydrate metabolic process4.92e-011.00e+000.57413274
GO:0007283spermatogenesis4.95e-011.00e+000.56412276
GO:0007264small GTPase mediated signal transduction5.12e-011.00e+000.49317290
GO:0006355regulation of transcription, DNA-templated5.14e-011.00e+000.1493101104
GO:0006200ATP catabolic process5.28e-011.00e+000.42914303
GO:0004674protein serine/threonine kinase activity5.38e-011.00e+000.38716312
GO:0035556intracellular signal transduction5.44e-011.00e+000.36415317
GO:0005575cellular_component5.50e-011.00e+000.34212322
GO:0008283cell proliferation5.60e-011.00e+000.30214331
GO:0045944positive regulation of transcription from RNA polymerase II promoter5.98e-011.00e+000.009211811
GO:0008285negative regulation of cell proliferation5.98e-011.00e+000.15313367
GO:0007155cell adhesion6.15e-011.00e+000.08813384
GO:0008284positive regulation of cell proliferation6.22e-011.00e+000.05817392
GO:0000139Golgi membrane6.37e-011.00e+000.00017408
GO:0006366transcription from RNA polymerase II promoter6.52e-011.00e+00-0.05913425
GO:0005524ATP binding6.56e-011.00e+00-0.1463191354
GO:0008150biological_process6.81e-011.00e+00-0.17013459
GO:0007165signal transduction6.85e-011.00e+00-0.21927950
GO:0007596blood coagulation6.85e-011.00e+00-0.18515464
GO:0046872metal ion binding7.09e-011.00e+00-0.2593141465
GO:0005886plasma membrane7.17e-011.00e+00-0.2116242834
GO:0008270zinc ion binding7.46e-011.00e+00-0.387271067
GO:0045087innate immune response7.86e-011.00e+00-0.594111616
GO:0005789endoplasmic reticulum membrane7.96e-011.00e+00-0.64013636
GO:0005615extracellular space9.23e-011.00e+00-1.308131010