int-snw-5714

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
tai-screen-luciferase 6.408 6.16e-138 2.88e-07 2.35e-03
tai-screen-luciferase-int-snw-5714 subnetwork

Genes (16)

Gene Symbol Entrez Gene ID Frequency tai-screen-luciferase gene score Best subnetwork score Degree List-Gonzales GI Tai-Hits
COPA 1314 32-9.3959.063170YesYes
RPS24 6229 21-7.0348.389217Yes-
RPS9 6203 18-7.1277.555140Yes-
COPB2 9276 32-13.1689.06341YesYes
COPZ1 22818 32-8.3019.06313YesYes
ATP6V1D 51382 8-4.1317.286149--
PSMD1 5707 3-3.6046.408113-Yes
PSMC6 5706 2-3.1696.408158--
RPS27A 6233 15-5.6318.389342Yes-
RPS11 6205 17-6.5887.555175Yes-
[ PSMD8 ] 5714 1-2.9166.408139--
PSMD3 5709 3-3.9356.408146-Yes
RPS6 6194 17-5.6038.046208Yes-
ARCN1 372 32-8.2329.063118YesYes
RPS26 6231 17-7.4788.04660Yes-
COPB1 1315 22-6.2219.063118YesYes

Interactions (32)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPS9 6203 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
PSMC6 5706 RPS27A 6233 pp -- int.I2D: YeastLow
COPA 1314 COPB1 1315 pp -- int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
RPS9 6203 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
COPA 1314 PSMD8 5714 pp -- int.I2D: YeastLow
ARCN1 372 COPA 1314 pp -- int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core;
int.HPRD: in vivo
PSMC6 5706 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh
ARCN1 372 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
COPA 1314 COPB2 9276 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vivo
PSMC6 5706 PSMD8 5714 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
RPS11 6205 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
PSMD1 5707 PSMD8 5714 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastMedium, Krogan_Core, MINT_Yeast
RPS6 6194 RPS27A 6233 pp -- int.I2D: YeastLow
PSMD8 5714 ATP6V1D 51382 pp -- int.I2D: YeastLow
COPA 1314 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
COPA 1314 ATP6V1D 51382 pp -- int.I2D: YeastLow
PSMD3 5709 PSMD8 5714 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, IntAct_Yeast, INTEROLOG, Krogan_Core, YeastHigh
ARCN1 372 COPB1 1315 pp -- int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS;
int.HPRD: in vivo
RPS6 6194 RPS26 6231 pp -- int.I2D: YeastLow
COPA 1314 RPS27A 6233 pp -- int.I2D: YeastLow
RPS6 6194 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
PSMC6 5706 PSMD1 5707 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid_Yeast, Krogan_Core, MINT_Yeast
PSMD1 5707 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, Krogan_Core
RPS6 6194 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS24 6229 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 COPB2 9276 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vivo
COPB1 1315 COPB2 9276 pp -- int.I2D: BioGrid
PSMC6 5706 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS24 6229 RPS27A 6233 pp -- int.I2D: YeastMedium
COPB1 1315 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium;
int.DIP: MI:0915(physical association)

Related GO terms (177)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0016071mRNA metabolic process4.71e-156.80e-115.3371025223
GO:0016070RNA metabolic process1.32e-141.91e-105.1901025247
GO:0016032viral process5.98e-138.63e-094.2151133534
GO:0005829cytosol6.22e-138.97e-092.53116612496
GO:0030126COPI vesicle coat6.63e-139.56e-098.5535712
GO:0048205COPI coating of Golgi vesicle1.08e-121.55e-088.4385813
GO:0022627cytosolic small ribosomal subunit2.05e-122.96e-087.11662039
GO:0006890retrograde vesicle-mediated transport, Golgi to ER4.41e-116.36e-077.4945825
GO:0019083viral transcription1.99e-102.87e-066.06162081
GO:0010467gene expression2.68e-103.87e-063.7521029669
GO:0016020membrane2.80e-104.04e-062.80113411681
GO:0006415translational termination3.09e-104.45e-065.95862087
GO:0006414translational elongation4.64e-106.69e-065.86262093
GO:0006614SRP-dependent cotranslational protein targeting to membrane9.18e-101.32e-055.701620104
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.60e-092.31e-055.568620114
GO:0019058viral life cycle1.69e-092.44e-055.556623115
GO:0015935small ribosomal subunit2.38e-093.44e-057.7294917
GO:0022624proteasome accessory complex2.38e-093.44e-057.7294417
GO:0006413translational initiation3.72e-095.36e-055.368621131
GO:0003735structural constituent of ribosome4.87e-097.03e-055.303622137
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest6.17e-098.90e-056.1385664
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.68e-099.64e-056.1165665
GO:0061024membrane organization6.86e-099.89e-055.221612145
GO:0000082G1/S transition of mitotic cell cycle8.08e-091.17e-045.18269149
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle9.76e-091.41e-046.0095870
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.13e-081.63e-045.9685672
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.30e-081.87e-045.9295874
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.39e-082.00e-045.9095675
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.81e-082.61e-045.8345879
GO:0002474antigen processing and presentation of peptide antigen via MHC class I3.91e-085.64e-045.6145692
GO:0006412translation1.08e-071.56e-034.556623230
GO:0000209protein polyubiquitination1.26e-071.81e-035.28057116
GO:0006521regulation of cellular amino acid metabolic process2.26e-073.25e-036.1724450
GO:0005838proteasome regulatory particle2.45e-073.53e-037.8163312
GO:0000502proteasome complex4.13e-075.96e-035.9584458
GO:0042981regulation of apoptotic process4.53e-076.54e-034.90957150
GO:0006891intra-Golgi vesicle-mediated transport7.54e-071.09e-027.3143417
GO:0006886intracellular protein transport8.68e-071.25e-024.72057171
GO:0043066negative regulation of apoptotic process3.88e-065.60e-023.673613424
GO:0044267cellular protein metabolic process7.38e-061.06e-013.512623474
GO:0034641cellular nitrogen compound metabolic process3.11e-054.48e-014.39844171
GO:0070062extracellular vesicular exosome4.83e-056.97e-011.90910402400
GO:0000278mitotic cell cycle4.87e-057.02e-013.527511391
GO:0044822poly(A) RNA binding7.02e-051.00e+002.5797321056
GO:0042274ribosomal small subunit biogenesis7.57e-051.00e+007.2312612
GO:0030234enzyme regulator activity8.94e-051.00e+007.1162213
GO:0042176regulation of protein catabolic process1.37e-041.00e+006.8162316
GO:0006915apoptotic process2.54e-041.00e+003.02259555
GO:0019843rRNA binding3.98e-041.00e+006.0612427
GO:0005198structural molecule activity5.59e-041.00e+004.17236150
GO:0033176proton-transporting V-type ATPase complex1.11e-031.00e+009.816111
GO:0021691cerebellar Purkinje cell layer maturation1.11e-031.00e+009.816111
GO:0022605oogenesis stage1.11e-031.00e+009.816111
GO:0005840ribosome1.84e-031.00e+004.9582858
GO:0006364rRNA processing4.75e-031.00e+004.2612794
GO:0005654nucleoplasm5.11e-031.00e+002.0595151082
GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)5.54e-031.00e+007.494135
GO:0033119negative regulation of RNA splicing5.54e-031.00e+007.494125
GO:0061512protein localization to cilium6.64e-031.00e+007.231116
GO:0002309T cell proliferation involved in immune response6.64e-031.00e+007.231116
GO:0045182translation regulator activity6.64e-031.00e+007.231126
GO:0006924activation-induced cell death of T cells6.64e-031.00e+007.231116
GO:0030529ribonucleoprotein complex6.68e-031.00e+004.00927112
GO:0030157pancreatic juice secretion7.74e-031.00e+007.009117
GO:0000028ribosomal small subunit assembly7.74e-031.00e+007.009137
GO:0034101erythrocyte homeostasis7.74e-031.00e+007.009117
GO:0044281small molecule metabolic process8.24e-031.00e+001.8965151211
GO:0008286insulin receptor signaling pathway1.06e-021.00e+003.66623142
GO:0005798Golgi-associated vesicle1.10e-021.00e+006.4941110
GO:0019082viral protein processing1.32e-021.00e+006.2311212
GO:0031929TOR signaling1.43e-021.00e+006.1161113
GO:0032479regulation of type I interferon production1.43e-021.00e+006.1161213
GO:0030131clathrin adaptor complex1.54e-021.00e+006.0091214
GO:0031369translation initiation factor binding1.65e-021.00e+005.9091115
GO:0048821erythrocyte development1.65e-021.00e+005.9091115
GO:0075733intracellular transport of virus1.87e-021.00e+005.7291317
GO:0019068virion assembly1.87e-021.00e+005.7291217
GO:0007369gastrulation2.09e-021.00e+005.5681119
GO:0043473pigmentation2.20e-021.00e+005.4941120
GO:0007220Notch receptor processing2.41e-021.00e+005.3571222
GO:0036464cytoplasmic ribonucleoprotein granule2.41e-021.00e+005.3571322
GO:0005844polysome2.52e-021.00e+005.2931223
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway2.74e-021.00e+005.1721225
GO:0005730nucleolus2.83e-021.00e+001.4585241641
GO:0005978glycogen biosynthetic process2.85e-021.00e+005.1161226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.85e-021.00e+005.1161226
GO:0042626ATPase activity, coupled to transmembrane movement of substances2.85e-021.00e+005.1161126
GO:0015992proton transport3.17e-021.00e+004.9581129
GO:0033572transferrin transport3.28e-021.00e+004.9091130
GO:0001890placenta development3.39e-021.00e+004.8621131
GO:0007093mitotic cell cycle checkpoint3.39e-021.00e+004.8621131
GO:0005737cytoplasm3.48e-021.00e+000.9378433767
GO:0043065positive regulation of apoptotic process3.48e-021.00e+002.75026268
GO:0051701interaction with host3.49e-021.00e+004.8161132
GO:0032480negative regulation of type I interferon production3.49e-021.00e+004.8161232
GO:0033077T cell differentiation in thymus3.60e-021.00e+004.7721133
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway3.92e-021.00e+004.6461336
GO:0090382phagosome maturation3.92e-021.00e+004.6461136
GO:0007249I-kappaB kinase/NF-kappaB signaling4.45e-021.00e+004.4591341
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway4.67e-021.00e+004.3901243
GO:0043231intracellular membrane-bounded organelle4.74e-021.00e+002.50325318
GO:0008344adult locomotory behavior4.77e-021.00e+004.3571144
GO:0044297cell body4.99e-021.00e+004.2931146
GO:0007254JNK cascade5.30e-021.00e+004.2011349
GO:0006879cellular iron ion homeostasis5.51e-021.00e+004.1441151
GO:0030674protein binding, bridging5.51e-021.00e+004.1441151
GO:0030666endocytic vesicle membrane5.72e-021.00e+004.0881253
GO:0051403stress-activated MAPK cascade5.83e-021.00e+004.0611354
GO:0005793endoplasmic reticulum-Golgi intermediate compartment6.04e-021.00e+004.0091156
GO:0005925focal adhesion6.10e-021.00e+002.300219366
GO:0016197endosomal transport6.14e-021.00e+003.9831357
GO:0032481positive regulation of type I interferon production6.56e-021.00e+003.8851361
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway6.56e-021.00e+003.8851261
GO:0006417regulation of translation6.66e-021.00e+003.8621262
GO:0034146toll-like receptor 5 signaling pathway6.98e-021.00e+003.7941465
GO:0034166toll-like receptor 10 signaling pathway6.98e-021.00e+003.7941465
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway7.60e-021.00e+003.6661471
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway7.60e-021.00e+003.6661471
GO:0003729mRNA binding7.70e-021.00e+003.6461272
GO:0034162toll-like receptor 9 signaling pathway7.70e-021.00e+003.6461472
GO:0034134toll-like receptor 2 signaling pathway7.80e-021.00e+003.6261473
GO:0035666TRIF-dependent toll-like receptor signaling pathway8.11e-021.00e+003.5681476
GO:0005929cilium8.21e-021.00e+003.5491177
GO:0055085transmembrane transport8.25e-021.00e+002.05123435
GO:0002756MyD88-independent toll-like receptor signaling pathway8.31e-021.00e+003.5311478
GO:0005179hormone activity8.42e-021.00e+003.5121179
GO:0034138toll-like receptor 3 signaling pathway8.42e-021.00e+003.5121479
GO:0002755MyD88-dependent toll-like receptor signaling pathway8.52e-021.00e+003.4941480
GO:0050852T cell receptor signaling pathway9.03e-021.00e+003.4071285
GO:0042384cilium assembly9.13e-021.00e+003.3901186
GO:0042593glucose homeostasis9.23e-021.00e+003.3731187
GO:0000187activation of MAPK activity9.53e-021.00e+003.3241290
GO:0001649osteoblast differentiation9.74e-021.00e+003.2931392
GO:0071456cellular response to hypoxia9.74e-021.00e+003.2931392
GO:0034142toll-like receptor 4 signaling pathway1.01e-011.00e+003.2311496
GO:0002224toll-like receptor signaling pathway1.14e-011.00e+003.04814109
GO:0097190apoptotic signaling pathway1.18e-011.00e+002.99613113
GO:0006006glucose metabolic process1.23e-011.00e+002.93313118
GO:0007219Notch signaling pathway1.25e-011.00e+002.90913120
GO:0051092positive regulation of NF-kappaB transcription factor activity1.29e-011.00e+002.86213124
GO:0006511ubiquitin-dependent protein catabolic process1.31e-011.00e+002.83912126
GO:0007179transforming growth factor beta receptor signaling pathway1.33e-011.00e+002.81613128
GO:0000086G2/M transition of mitotic cell cycle1.41e-011.00e+002.72915136
GO:0016887ATPase activity1.45e-011.00e+002.68711140
GO:0005794Golgi apparatus1.45e-011.00e+001.56329610
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling1.49e-011.00e+002.63613145
GO:0034220ion transmembrane transport1.53e-011.00e+002.59712149
GO:0010008endosome membrane1.55e-011.00e+002.57815151
GO:0008543fibroblast growth factor receptor signaling pathway1.60e-011.00e+002.53113156
GO:0038095Fc-epsilon receptor signaling pathway1.71e-011.00e+002.42413168
GO:0006367transcription initiation from RNA polymerase II promoter1.86e-011.00e+002.29313184
GO:0007173epidermal growth factor receptor signaling pathway1.90e-011.00e+002.25414189
GO:0005765lysosomal membrane2.03e-011.00e+002.15112203
GO:0019221cytokine-mediated signaling pathway2.19e-011.00e+002.02812221
GO:0007067mitotic nuclear division2.24e-011.00e+001.99015227
GO:0030425dendrite2.27e-011.00e+001.97112230
GO:0005975carbohydrate metabolic process2.47e-011.00e+001.83313253
GO:0000166nucleotide binding2.52e-011.00e+001.79912259
GO:0006281DNA repair2.53e-011.00e+001.78814261
GO:0048011neurotrophin TRK receptor signaling pathway2.60e-011.00e+001.74514269
GO:0006200ATP catabolic process2.79e-011.00e+001.62613292
GO:0019901protein kinase binding2.99e-011.00e+001.50816317
GO:0005813centrosome3.06e-011.00e+001.46715326
GO:0000139Golgi membrane3.34e-011.00e+001.32016361
GO:0008284positive regulation of cell proliferation3.49e-011.00e+001.23917382
GO:0005634nucleus3.94e-011.00e+000.2476434559
GO:0048471perinuclear region of cytoplasm4.33e-011.00e+000.84517502
GO:0005783endoplasmic reticulum4.67e-011.00e+000.69713556
GO:0000122negative regulation of transcription from RNA polymerase II promoter4.76e-011.00e+000.66117570
GO:0045087innate immune response4.91e-011.00e+000.59718596
GO:0005515protein binding5.31e-011.00e+000.0677626024
GO:0045944positive regulation of transcription from RNA polymerase II promoter5.94e-011.00e+000.19216789
GO:0005615extracellular space6.67e-011.00e+00-0.08612957
GO:0005524ATP binding7.79e-011.00e+00-0.5261151298
GO:0046872metal ion binding7.81e-011.00e+00-0.5361101307
GO:0005886plasma membrane8.09e-011.00e+00-0.5182202582
GO:0006351transcription, DNA-templated8.16e-011.00e+00-0.682161446