reg-snw-5770

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
tai-screen-luciferase	4.418	2.91e-21	1.75e-03	2.57e-03

tai-screen-luciferase-reg-snw-5770 subnetwork

Genes (13)

Gene Symbol	Entrez Gene ID	Frequency	tai-screen-luciferase gene score	Best subnetwork score	Degree	Transcription factor	List-Gonzales GI	Tai-Hits
EIF2S2	8894	11	-4.320	5.672	22	-	Yes	-
[ PTPN1 ]	5770	1	2.067	4.418	1	-	-	-
COPA	1314	25	-9.395	5.672	170	TF	Yes	Yes
PSMD8	5714	1	-2.916	4.418	4	-	-	-
PSMD3	5709	3	-3.935	4.903	55	TF	-	Yes
HSF1	3297	8	-4.179	5.027	138	TF	-	Yes
TLK2	11011	8	-4.011	5.672	14	-	-	-
MRPS12	6183	13	-5.421	5.516	307	TF	Yes	-
YBX1	4904	6	-3.033	5.516	120	TF	-	-
GCN1L1	10985	1	-2.918	4.418	43	TF	-	-
SERBP1	26135	10	-4.612	5.516	43	-	-	Yes
CKAP5	9793	20	-7.214	5.672	89	TF	Yes	Yes
CDC5L	988	15	-3.419	5.672	155	TF	-	-

Interactions (14)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
YBX1	4904	PTPN1	5770	pd	>	reg.TRANSFAC.txt: no annot
HSF1	3297	MRPS12	6183	pd	<>	reg.ITFP.txt: no annot
PSMD3	5709	GCN1L1	10985	pd	<>	reg.ITFP.txt: no annot
CDC5L	988	COPA	1314	pd	<>	reg.ITFP.txt: no annot
CDC5L	988	YBX1	4904	pd	<>	reg.ITFP.txt: no annot
YBX1	4904	GCN1L1	10985	pd	<>	reg.ITFP.txt: no annot
PSMD3	5709	MRPS12	6183	pd	<>	reg.ITFP.txt: no annot
YBX1	4904	PSMD8	5714	pd	>	reg.ITFP.txt: no annot
YBX1	4904	MRPS12	6183	pd	<>	reg.ITFP.txt: no annot
CDC5L	988	TLK2	11011	pd	>	reg.ITFP.txt: no annot
CDC5L	988	CKAP5	9793	pd	<>	reg.ITFP.txt: no annot
YBX1	4904	SERBP1	26135	pd	>	reg.ITFP.txt: no annot
CDC5L	988	EIF2S2	8894	pd	>	reg.ITFP.txt: no annot
PSMD8	5714	MRPS12	6183	pd	<	reg.ITFP.txt: no annot

Related GO terms (165)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0044822	poly(A) RNA binding	2.65e-05	2.58e-01	2.718	7	25	799
GO:0005838	proteasome regulatory particle	7.32e-05	7.15e-01	7.231	2	2	10
GO:0022624	proteasome accessory complex	1.48e-04	1.00e+00	6.746	2	2	14
GO:0008135	translation factor activity, nucleic acid binding	1.70e-04	1.00e+00	6.646	2	4	15
GO:0042981	regulation of apoptotic process	3.86e-04	1.00e+00	4.331	3	4	112
GO:0006521	regulation of cellular amino acid metabolic process	1.30e-03	1.00e+00	5.195	2	3	41
GO:0071987	WD40-repeat domain binding	1.33e-03	1.00e+00	9.553	1	1	1
GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	1.33e-03	1.00e+00	9.553	1	1	1
GO:0006412	translation	1.49e-03	1.00e+00	3.662	3	13	178
GO:0000502	proteasome complex	1.71e-03	1.00e+00	4.998	2	2	47
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.09e-03	1.00e+00	4.853	2	3	52
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	2.17e-03	1.00e+00	4.825	2	3	53
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.42e-03	1.00e+00	4.746	2	3	56
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	2.51e-03	1.00e+00	4.720	2	3	57
GO:0001672	regulation of chromatin assembly or disassembly	2.66e-03	1.00e+00	8.553	1	1	2
GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	2.66e-03	1.00e+00	8.553	1	1	2
GO:0002176	male germ cell proliferation	2.66e-03	1.00e+00	8.553	1	1	2
GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway	2.66e-03	1.00e+00	8.553	1	1	2
GO:0090231	regulation of spindle checkpoint	2.66e-03	1.00e+00	8.553	1	1	2
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	2.66e-03	1.00e+00	8.553	1	1	2
GO:0072422	signal transduction involved in DNA damage checkpoint	2.66e-03	1.00e+00	8.553	1	1	2
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.77e-03	1.00e+00	4.646	2	3	60
GO:0016020	membrane	2.79e-03	1.00e+00	1.901	6	25	1207
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	2.86e-03	1.00e+00	4.622	2	3	61
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	3.25e-03	1.00e+00	4.531	2	3	65
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	3.75e-03	1.00e+00	4.424	2	4	70
GO:0005850	eukaryotic translation initiation factor 2 complex	3.99e-03	1.00e+00	7.968	1	1	3
GO:0051154	negative regulation of striated muscle cell differentiation	3.99e-03	1.00e+00	7.968	1	1	3
GO:0007143	female meiotic division	3.99e-03	1.00e+00	7.968	1	1	3
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	3.99e-03	1.00e+00	7.968	1	1	3
GO:0097443	sorting endosome	3.99e-03	1.00e+00	7.968	1	1	3
GO:0010467	gene expression	4.28e-03	1.00e+00	2.490	4	17	535
GO:0050658	RNA transport	5.32e-03	1.00e+00	7.553	1	1	4
GO:0030157	pancreatic juice secretion	5.32e-03	1.00e+00	7.553	1	1	4
GO:0000209	protein polyubiquitination	6.40e-03	1.00e+00	4.029	2	3	92
GO:0000974	Prp19 complex	6.64e-03	1.00e+00	7.231	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	6.64e-03	1.00e+00	7.231	1	1	5
GO:0071204	histone pre-mRNA 3'end processing complex	6.64e-03	1.00e+00	7.231	1	1	5
GO:0000930	gamma-tubulin complex	6.64e-03	1.00e+00	7.231	1	1	5
GO:0000278	mitotic cell cycle	7.41e-03	1.00e+00	2.843	3	9	314
GO:0060136	embryonic process involved in female pregnancy	7.96e-03	1.00e+00	6.968	1	1	6
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	7.96e-03	1.00e+00	6.968	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	7.96e-03	1.00e+00	6.968	1	1	6
GO:0034641	cellular nitrogen compound metabolic process	8.27e-03	1.00e+00	3.839	2	3	105
GO:0030126	COPI vesicle coat	9.28e-03	1.00e+00	6.746	1	1	7
GO:0005662	DNA replication factor A complex	1.06e-02	1.00e+00	6.553	1	1	8
GO:0000082	G1/S transition of mitotic cell cycle	1.16e-02	1.00e+00	3.587	2	6	125
GO:0030100	regulation of endocytosis	1.19e-02	1.00e+00	6.383	1	1	9
GO:0000398	mRNA splicing, via spliceosome	1.21e-02	1.00e+00	3.553	2	2	128
GO:0071480	cellular response to gamma radiation	1.32e-02	1.00e+00	6.231	1	1	10
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	1.32e-02	1.00e+00	6.231	1	1	10
GO:0007051	spindle organization	1.32e-02	1.00e+00	6.231	1	1	10
GO:0010507	negative regulation of autophagy	1.32e-02	1.00e+00	6.231	1	1	10
GO:0043488	regulation of mRNA stability	1.32e-02	1.00e+00	6.231	1	1	10
GO:0009966	regulation of signal transduction	1.46e-02	1.00e+00	6.094	1	1	11
GO:0030234	enzyme regulator activity	1.46e-02	1.00e+00	6.094	1	1	11
GO:0045120	pronucleus	1.46e-02	1.00e+00	6.094	1	1	11
GO:0051297	centrosome organization	1.59e-02	1.00e+00	5.968	1	1	12
GO:0048205	COPI coating of Golgi vesicle	1.59e-02	1.00e+00	5.968	1	1	12
GO:0015935	small ribosomal subunit	1.59e-02	1.00e+00	5.968	1	4	12
GO:0035371	microtubule plus-end	1.72e-02	1.00e+00	5.853	1	1	13
GO:0001701	in utero embryonic development	1.72e-02	1.00e+00	3.286	2	2	154
GO:0042176	regulation of protein catabolic process	1.85e-02	1.00e+00	5.746	1	3	14
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	1.98e-02	1.00e+00	5.646	1	1	15
GO:0005829	cytosol	1.98e-02	1.00e+00	1.335	6	33	1787
GO:0016071	mRNA metabolic process	2.07e-02	1.00e+00	3.144	2	11	170
GO:0060338	regulation of type I interferon-mediated signaling pathway	2.11e-02	1.00e+00	5.553	1	1	16
GO:0005689	U12-type spliceosomal complex	2.24e-02	1.00e+00	5.466	1	2	17
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	2.24e-02	1.00e+00	5.466	1	1	17
GO:0046627	negative regulation of insulin receptor signaling pathway	2.50e-02	1.00e+00	5.305	1	1	19
GO:0016070	RNA metabolic process	2.50e-02	1.00e+00	2.998	2	11	188
GO:0001892	embryonic placenta development	2.63e-02	1.00e+00	5.231	1	1	20
GO:0032720	negative regulation of tumor necrosis factor production	2.63e-02	1.00e+00	5.231	1	1	20
GO:0005761	mitochondrial ribosome	2.63e-02	1.00e+00	5.231	1	1	20
GO:0046875	ephrin receptor binding	2.63e-02	1.00e+00	5.231	1	1	20
GO:0051781	positive regulation of cell division	2.89e-02	1.00e+00	5.094	1	1	22
GO:0040018	positive regulation of multicellular organism growth	2.89e-02	1.00e+00	5.094	1	1	22
GO:0034605	cellular response to heat	2.89e-02	1.00e+00	5.094	1	1	22
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	3.02e-02	1.00e+00	5.029	1	1	23
GO:0043234	protein complex	3.07e-02	1.00e+00	2.839	2	8	210
GO:0070373	negative regulation of ERK1 and ERK2 cascade	3.28e-02	1.00e+00	4.909	1	1	25
GO:0003730	mRNA 3'-UTR binding	3.28e-02	1.00e+00	4.909	1	1	25
GO:0005158	insulin receptor binding	3.28e-02	1.00e+00	4.909	1	1	25
GO:0030971	receptor tyrosine kinase binding	3.41e-02	1.00e+00	4.853	1	1	26
GO:0010494	cytoplasmic stress granule	3.41e-02	1.00e+00	4.853	1	2	26
GO:0005737	cytoplasm	3.61e-02	1.00e+00	0.998	7	39	2633
GO:0031532	actin cytoskeleton reorganization	4.05e-02	1.00e+00	4.599	1	2	31
GO:0003723	RNA binding	4.14e-02	1.00e+00	2.605	2	6	247
GO:0003682	chromatin binding	4.29e-02	1.00e+00	2.576	2	3	252
GO:0005515	protein binding	4.61e-02	1.00e+00	0.713	9	50	4124
GO:0003743	translation initiation factor activity	4.82e-02	1.00e+00	4.344	1	5	37
GO:0006952	defense response	4.82e-02	1.00e+00	4.344	1	1	37
GO:0006417	regulation of translation	5.07e-02	1.00e+00	4.268	1	3	39
GO:0005840	ribosome	5.20e-02	1.00e+00	4.231	1	3	40
GO:0005882	intermediate filament	5.20e-02	1.00e+00	4.231	1	2	40
GO:0070062	extracellular vesicular exosome	5.26e-02	1.00e+00	1.195	5	28	1641
GO:0060337	type I interferon signaling pathway	5.83e-02	1.00e+00	4.061	1	1	45
GO:0006468	protein phosphorylation	5.90e-02	1.00e+00	2.319	2	3	301
GO:0004725	protein tyrosine phosphatase activity	6.33e-02	1.00e+00	3.938	1	1	49
GO:0007059	chromosome segregation	6.46e-02	1.00e+00	3.909	1	1	50
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	6.46e-02	1.00e+00	3.909	1	1	50
GO:0018105	peptidyl-serine phosphorylation	6.58e-02	1.00e+00	3.881	1	2	51
GO:0043066	negative regulation of apoptotic process	6.65e-02	1.00e+00	2.222	2	6	322
GO:0005730	nucleolus	6.82e-02	1.00e+00	1.304	4	21	1217
GO:0060333	interferon-gamma-mediated signaling pathway	6.96e-02	1.00e+00	3.798	1	1	54
GO:0008584	male gonad development	7.33e-02	1.00e+00	3.720	1	1	57
GO:0003697	single-stranded DNA binding	7.33e-02	1.00e+00	3.720	1	3	57
GO:0048471	perinuclear region of cytoplasm	7.47e-02	1.00e+00	2.127	2	7	344
GO:0005179	hormone activity	7.70e-02	1.00e+00	3.646	1	1	60
GO:0035335	peptidyl-tyrosine dephosphorylation	7.70e-02	1.00e+00	3.646	1	2	60
GO:0071013	catalytic step 2 spliceosome	7.83e-02	1.00e+00	3.622	1	1	61
GO:0030968	endoplasmic reticulum unfolded protein response	7.83e-02	1.00e+00	3.622	1	1	61
GO:0000922	spindle pole	8.69e-02	1.00e+00	3.466	1	3	68
GO:0016568	chromatin modification	8.69e-02	1.00e+00	3.466	1	2	68
GO:0031410	cytoplasmic vesicle	9.42e-02	1.00e+00	3.344	1	1	74
GO:0015630	microtubule cytoskeleton	9.54e-02	1.00e+00	3.324	1	2	75
GO:0006915	apoptotic process	1.02e-01	1.00e+00	1.870	2	4	411
GO:0005634	nucleus	1.02e-01	1.00e+00	0.696	7	40	3246
GO:0005654	nucleoplasm	1.04e-01	1.00e+00	1.363	3	16	876
GO:0030529	ribonucleoprotein complex	1.04e-01	1.00e+00	3.195	1	3	82
GO:0003690	double-stranded DNA binding	1.05e-01	1.00e+00	3.178	1	1	83
GO:0016032	viral process	1.09e-01	1.00e+00	1.811	2	13	428
GO:0061024	membrane organization	1.12e-01	1.00e+00	3.077	1	3	89
GO:0006886	intracellular protein transport	1.12e-01	1.00e+00	3.077	1	1	89
GO:0032496	response to lipopolysaccharide	1.17e-01	1.00e+00	3.014	1	1	93
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	1.21e-01	1.00e+00	1.720	2	6	456
GO:0000086	G2/M transition of mitotic cell cycle	1.22e-01	1.00e+00	2.953	1	3	97
GO:0008286	insulin receptor signaling pathway	1.22e-01	1.00e+00	2.953	1	2	97
GO:0006413	translational initiation	1.24e-01	1.00e+00	2.924	1	12	99
GO:0005198	structural molecule activity	1.26e-01	1.00e+00	2.895	1	1	101
GO:0003735	structural constituent of ribosome	1.36e-01	1.00e+00	2.785	1	8	109
GO:0005769	early endosome	1.36e-01	1.00e+00	2.785	1	1	109
GO:0007049	cell cycle	1.43e-01	1.00e+00	2.707	1	2	115
GO:0006974	cellular response to DNA damage stimulus	1.50e-01	1.00e+00	2.634	1	2	121
GO:0016607	nuclear speck	1.51e-01	1.00e+00	2.622	1	2	122
GO:0031965	nuclear membrane	1.60e-01	1.00e+00	2.531	1	2	130
GO:0030168	platelet activation	1.72e-01	1.00e+00	2.413	1	3	141
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.73e-01	1.00e+00	2.403	1	4	142
GO:0003700	sequence-specific DNA binding transcription factor activity	1.79e-01	1.00e+00	1.368	2	9	582
GO:0008380	RNA splicing	1.99e-01	1.00e+00	2.187	1	4	165
GO:0007067	mitotic nuclear division	1.99e-01	1.00e+00	2.187	1	5	165
GO:0007283	spermatogenesis	2.02e-01	1.00e+00	2.161	1	2	168
GO:0019221	cytokine-mediated signaling pathway	2.06e-01	1.00e+00	2.127	1	4	172
GO:0004674	protein serine/threonine kinase activity	2.33e-01	1.00e+00	1.931	1	3	197
GO:0035556	intracellular signal transduction	2.35e-01	1.00e+00	1.916	1	3	199
GO:0006355	regulation of transcription, DNA-templated	2.46e-01	1.00e+00	1.071	2	9	715
GO:0019899	enzyme binding	2.46e-01	1.00e+00	1.839	1	3	210
GO:0005813	centrosome	2.53e-01	1.00e+00	1.791	1	6	217
GO:0043231	intracellular membrane-bounded organelle	2.54e-01	1.00e+00	1.785	1	1	218
GO:0019901	protein kinase binding	2.69e-01	1.00e+00	1.695	1	8	232
GO:0044281	small molecule metabolic process	3.11e-01	1.00e+00	0.832	2	8	844
GO:0008285	negative regulation of cell proliferation	3.12e-01	1.00e+00	1.439	1	3	277
GO:0003677	DNA binding	3.64e-01	1.00e+00	0.666	2	12	947
GO:0007596	blood coagulation	3.68e-01	1.00e+00	1.148	1	4	339
GO:0006366	transcription from RNA polymerase II promoter	3.70e-01	1.00e+00	1.139	1	2	341
GO:0044267	cellular protein metabolic process	3.80e-01	1.00e+00	1.094	1	13	352
GO:0005783	endoplasmic reticulum	4.04e-01	1.00e+00	0.979	1	3	381
GO:0005789	endoplasmic reticulum membrane	4.09e-01	1.00e+00	0.957	1	3	387
GO:0006351	transcription, DNA-templated	4.28e-01	1.00e+00	0.482	2	15	1076
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	5.88e-01	1.00e+00	0.222	1	8	644
GO:0005615	extracellular space	5.92e-01	1.00e+00	0.206	1	2	651
GO:0008270	zinc ion binding	6.34e-01	1.00e+00	0.047	1	5	727
GO:0005524	ATP binding	7.12e-01	1.00e+00	-0.248	1	10	892
GO:0005886	plasma membrane	7.17e-01	1.00e+00	-0.248	2	13	1784
GO:0046872	metal ion binding	7.30e-01	1.00e+00	-0.314	1	10	934

Tai-Luciferase

reg-snw-5770

Statistics

Genes (13)

Interactions (14)

Related GO terms (165)