reg-snw-9330

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.428	1.70e-08	9.68e-03	8.45e-03

chia-screen-data-Fav-reg-snw-9330 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Transcription factor	Chia-Hits Primary	Chia-Hits Secondary
TDP1	55775	5	-1.669	2.428	52	-	-	-
KARS	3735	12	-1.759	2.428	123	TF	-	-
EIF2S2	8894	40	-2.999	2.459	22	-	Yes	Yes
SYNCRIP	10492	42	-2.401	2.503	144	TF	Yes	Yes
PHB2	11331	17	-2.236	2.449	11	-	Yes	-
PHB	5245	82	-2.743	2.689	36	-	Yes	Yes
ETF1	2107	35	-2.829	2.503	6	-	Yes	Yes
GSPT1	2935	32	-2.313	2.503	17	-	Yes	Yes
[ GTF3C3 ]	9330	5	-1.450	2.428	62	TF	-	-
CPSF3	51692	43	-2.686	2.503	31	-	Yes	Yes
GPS1	2873	86	-3.621	2.689	36	TF	Yes	Yes

Interactions (12)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
KARS	3735	GTF3C3	9330	pd	<>	reg.ITFP.txt: no annot
GTF3C3	9330	TDP1	55775	pd	>	reg.ITFP.txt: no annot
KARS	3735	PHB2	11331	pd	>	reg.ITFP.txt: no annot
ETF1	2107	SYNCRIP	10492	pd	<	reg.ITFP.txt: no annot
KARS	3735	PHB	5245	pd	>	reg.ITFP.txt: no annot
GSPT1	2935	SYNCRIP	10492	pd	<	reg.ITFP.txt: no annot
SYNCRIP	10492	TDP1	55775	pd	>	reg.ITFP.txt: no annot
GSPT1	2935	KARS	3735	pd	<	reg.ITFP.txt: no annot
GPS1	2873	PHB	5245	pd	>	reg.ITFP.txt: no annot
EIF2S2	8894	GTF3C3	9330	pd	<	reg.ITFP.txt: no annot
SYNCRIP	10492	CPSF3	51692	pd	>	reg.ITFP.txt: no annot
GPS1	2873	PHB2	11331	pd	>	reg.ITFP.txt: no annot

Related GO terms (124)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0003747	translation release factor activity	1.15e-06	1.13e-02	9.794	2	2	2
GO:0006479	protein methylation	6.31e-05	6.16e-01	7.335	2	2	11
GO:0005515	protein binding	7.56e-05	7.39e-01	1.244	11	198	4124
GO:0003723	RNA binding	1.15e-04	1.00e+00	3.846	4	22	247
GO:0010467	gene expression	1.70e-04	1.00e+00	3.053	5	49	535
GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	1.13e-03	1.00e+00	9.794	1	1	1
GO:0016149	translation release factor activity, codon specific	1.13e-03	1.00e+00	9.794	1	1	1
GO:0008079	translation termination factor activity	1.13e-03	1.00e+00	9.794	1	1	1
GO:0006430	lysyl-tRNA aminoacylation	1.13e-03	1.00e+00	9.794	1	1	1
GO:0004824	lysine-tRNA ligase activity	1.13e-03	1.00e+00	9.794	1	1	1
GO:0006415	translational termination	2.17e-03	1.00e+00	4.817	2	2	63
GO:0015966	diadenosine tetraphosphate biosynthetic process	2.25e-03	1.00e+00	8.794	1	1	2
GO:0002176	male germ cell proliferation	2.25e-03	1.00e+00	8.794	1	1	2
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	2.25e-03	1.00e+00	8.794	1	1	2
GO:0001649	osteoblast differentiation	2.98e-03	1.00e+00	4.585	2	5	74
GO:0005850	eukaryotic translation initiation factor 2 complex	3.38e-03	1.00e+00	8.209	1	2	3
GO:0030529	ribonucleoprotein complex	3.65e-03	1.00e+00	4.436	2	5	82
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	3.82e-03	1.00e+00	4.402	2	5	84
GO:0006449	regulation of translational termination	4.50e-03	1.00e+00	7.794	1	1	4
GO:0000012	single strand break repair	4.50e-03	1.00e+00	7.794	1	1	4
GO:0097452	GAIT complex	4.50e-03	1.00e+00	7.794	1	2	4
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	4.50e-03	1.00e+00	7.794	1	1	4
GO:0004521	endoribonuclease activity	5.62e-03	1.00e+00	7.472	1	1	5
GO:0042797	tRNA transcription from RNA polymerase III promoter	5.62e-03	1.00e+00	7.472	1	3	5
GO:0060744	mammary gland branching involved in thelarche	5.62e-03	1.00e+00	7.472	1	1	5
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	5.62e-03	1.00e+00	7.472	1	1	5
GO:0006398	histone mRNA 3'-end processing	5.62e-03	1.00e+00	7.472	1	1	5
GO:0071204	histone pre-mRNA 3'end processing complex	5.62e-03	1.00e+00	7.472	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	5.62e-03	1.00e+00	7.472	1	2	5
GO:0000127	transcription factor TFIIIC complex	5.62e-03	1.00e+00	7.472	1	3	5
GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter	5.62e-03	1.00e+00	7.472	1	3	5
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	5.62e-03	1.00e+00	7.472	1	1	5
GO:0050847	progesterone receptor signaling pathway	6.74e-03	1.00e+00	7.209	1	2	6
GO:0070937	CRD-mediated mRNA stability complex	6.74e-03	1.00e+00	7.209	1	2	6
GO:0008409	5'-3' exonuclease activity	7.86e-03	1.00e+00	6.987	1	2	7
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	7.86e-03	1.00e+00	6.987	1	2	7
GO:0000398	mRNA splicing, via spliceosome	8.68e-03	1.00e+00	3.794	2	15	128
GO:0010944	negative regulation of transcription by competitive promoter binding	8.98e-03	1.00e+00	6.794	1	1	8
GO:0010388	cullin deneddylation	8.98e-03	1.00e+00	6.794	1	4	8
GO:0044822	poly(A) RNA binding	9.20e-03	1.00e+00	2.152	4	45	799
GO:0006379	mRNA cleavage	1.01e-02	1.00e+00	6.624	1	2	9
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	1.01e-02	1.00e+00	6.624	1	3	9
GO:0071354	cellular response to interleukin-6	1.01e-02	1.00e+00	6.624	1	1	9
GO:0005095	GTPase inhibitor activity	1.12e-02	1.00e+00	6.472	1	1	10
GO:0008143	poly(A) binding	1.12e-02	1.00e+00	6.472	1	2	10
GO:0060766	negative regulation of androgen receptor signaling pathway	1.23e-02	1.00e+00	6.335	1	4	11
GO:0005654	nucleoplasm	1.27e-02	1.00e+00	2.019	4	68	876
GO:0004527	exonuclease activity	1.34e-02	1.00e+00	6.209	1	4	12
GO:0008380	RNA splicing	1.41e-02	1.00e+00	3.428	2	21	165
GO:0060749	mammary gland alveolus development	1.46e-02	1.00e+00	6.094	1	1	13
GO:0016597	amino acid binding	1.57e-02	1.00e+00	5.987	1	1	14
GO:0016575	histone deacetylation	1.57e-02	1.00e+00	5.987	1	2	14
GO:0006412	translation	1.63e-02	1.00e+00	3.318	2	12	178
GO:0000188	inactivation of MAPK activity	1.68e-02	1.00e+00	5.887	1	1	15
GO:0008135	translation factor activity, nucleic acid binding	1.68e-02	1.00e+00	5.887	1	4	15
GO:0043022	ribosome binding	1.90e-02	1.00e+00	5.707	1	2	17
GO:0005743	mitochondrial inner membrane	1.98e-02	1.00e+00	3.172	2	9	197
GO:0006378	mRNA polyadenylation	2.01e-02	1.00e+00	5.624	1	3	18
GO:0071346	cellular response to interferon-gamma	2.23e-02	1.00e+00	5.472	1	2	20
GO:0071897	DNA biosynthetic process	2.23e-02	1.00e+00	5.472	1	2	20
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	2.34e-02	1.00e+00	5.402	1	2	21
GO:0030331	estrogen receptor binding	2.45e-02	1.00e+00	5.335	1	2	22
GO:0000049	tRNA binding	2.56e-02	1.00e+00	5.270	1	2	23
GO:0008180	COP9 signalosome	2.67e-02	1.00e+00	5.209	1	6	24
GO:0008033	tRNA processing	2.78e-02	1.00e+00	5.150	1	2	25
GO:0006418	tRNA aminoacylation for protein translation	3.22e-02	1.00e+00	4.936	1	4	29
GO:0006383	transcription from RNA polymerase III promoter	3.22e-02	1.00e+00	4.936	1	6	29
GO:0005739	mitochondrion	3.36e-02	1.00e+00	2.015	3	32	659
GO:0090305	nucleic acid phosphodiester bond hydrolysis	3.44e-02	1.00e+00	4.840	1	6	31
GO:0017148	negative regulation of translation	3.66e-02	1.00e+00	4.750	1	5	33
GO:0007254	JNK cascade	3.77e-02	1.00e+00	4.707	1	1	34
GO:0031124	mRNA 3'-end processing	3.87e-02	1.00e+00	4.665	1	4	35
GO:0003743	translation initiation factor activity	4.09e-02	1.00e+00	4.585	1	8	37
GO:0006369	termination of RNA polymerase II transcription	4.20e-02	1.00e+00	4.546	1	5	38
GO:0006396	RNA processing	4.42e-02	1.00e+00	4.472	1	4	40
GO:0045892	negative regulation of transcription, DNA-templated	4.76e-02	1.00e+00	2.486	2	17	317
GO:0006406	mRNA export from nucleus	4.85e-02	1.00e+00	4.335	1	7	44
GO:0006302	double-strand break repair	5.71e-02	1.00e+00	4.094	1	5	52
GO:0044267	cellular protein metabolic process	5.75e-02	1.00e+00	2.335	2	14	352
GO:0008584	male gonad development	6.24e-02	1.00e+00	3.961	1	1	57
GO:0003697	single-stranded DNA binding	6.24e-02	1.00e+00	3.961	1	4	57
GO:0042826	histone deacetylase binding	6.35e-02	1.00e+00	3.936	1	5	58
GO:0071013	catalytic step 2 spliceosome	6.66e-02	1.00e+00	3.863	1	5	61
GO:0030308	negative regulation of cell growth	7.61e-02	1.00e+00	3.665	1	3	70
GO:0016363	nuclear matrix	7.93e-02	1.00e+00	3.604	1	10	73
GO:0046872	metal ion binding	8.04e-02	1.00e+00	1.512	3	24	934
GO:0016032	viral process	8.12e-02	1.00e+00	2.053	2	30	428
GO:0015630	microtubule cytoskeleton	8.14e-02	1.00e+00	3.565	1	5	75
GO:0003690	double-stranded DNA binding	8.97e-02	1.00e+00	3.419	1	6	83
GO:0006413	translational initiation	1.06e-01	1.00e+00	3.165	1	6	99
GO:0042981	regulation of apoptotic process	1.19e-01	1.00e+00	2.987	1	4	112
GO:0005634	nucleus	1.21e-01	1.00e+00	0.714	6	158	3246
GO:0007049	cell cycle	1.22e-01	1.00e+00	2.948	1	8	115
GO:0003924	GTPase activity	1.26e-01	1.00e+00	2.899	1	7	119
GO:0000082	G1/S transition of mitotic cell cycle	1.32e-01	1.00e+00	2.828	1	4	125
GO:0006184	GTP catabolic process	1.37e-01	1.00e+00	2.772	1	7	130
GO:0005759	mitochondrial matrix	1.46e-01	1.00e+00	2.675	1	7	139
GO:0005737	cytoplasm	1.48e-01	1.00e+00	0.753	5	127	2633
GO:0044212	transcription regulatory region DNA binding	1.50e-01	1.00e+00	2.634	1	13	143
GO:0005622	intracellular	1.52e-01	1.00e+00	2.614	1	2	145
GO:0001701	in utero embryonic development	1.61e-01	1.00e+00	2.527	1	7	154
GO:0016071	mRNA metabolic process	1.76e-01	1.00e+00	2.385	1	10	170
GO:0000166	nucleotide binding	1.81e-01	1.00e+00	2.335	1	13	176
GO:0016070	RNA metabolic process	1.93e-01	1.00e+00	2.239	1	10	188
GO:0005525	GTP binding	2.01e-01	1.00e+00	2.172	1	12	197
GO:0006281	DNA repair	2.06e-01	1.00e+00	2.129	1	24	203
GO:0043234	protein complex	2.13e-01	1.00e+00	2.080	1	13	210
GO:0019899	enzyme binding	2.13e-01	1.00e+00	2.080	1	7	210
GO:0008285	negative regulation of cell proliferation	2.71e-01	1.00e+00	1.680	1	11	277
GO:0006366	transcription from RNA polymerase II promoter	3.24e-01	1.00e+00	1.380	1	23	341
GO:0005829	cytosol	3.26e-01	1.00e+00	0.576	3	88	1787
GO:0006351	transcription, DNA-templated	3.46e-01	1.00e+00	0.723	2	47	1076
GO:0045893	positive regulation of transcription, DNA-templated	3.52e-01	1.00e+00	1.236	1	21	377
GO:0005783	endoplasmic reticulum	3.55e-01	1.00e+00	1.220	1	12	381
GO:0016020	membrane	4.02e-01	1.00e+00	0.557	2	56	1207
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	4.09e-01	1.00e+00	0.961	1	29	456
GO:0005887	integral component of plasma membrane	4.87e-01	1.00e+00	0.627	1	8	575
GO:0007165	signal transduction	5.13e-01	1.00e+00	0.523	1	24	618
GO:0005576	extracellular region	5.39e-01	1.00e+00	0.421	1	15	663
GO:0006355	regulation of transcription, DNA-templated	5.67e-01	1.00e+00	0.312	1	31	715
GO:0070062	extracellular vesicular exosome	5.74e-01	1.00e+00	0.114	2	51	1641
GO:0005524	ATP binding	6.52e-01	1.00e+00	-0.007	1	37	892
GO:0003677	DNA binding	6.75e-01	1.00e+00	-0.093	1	52	947
GO:0005886	plasma membrane	8.91e-01	1.00e+00	-1.007	1	46	1784

chia-Fav

reg-snw-9330

Statistics

Genes (11)

Interactions (12)

Related GO terms (124)