reg-snw-11180

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.242	1.75e-07	3.61e-02	2.77e-02

chia-screen-data-Fav-reg-snw-11180 subnetwork

Genes (17)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Transcription factor	Chia-Hits Primary	Chia-Hits Secondary
AKT2	208	2	-1.664	2.338	21	TF	-	-
PHB	5245	82	-2.743	2.689	36	-	Yes	Yes
RANGAP1	5905	3	-1.596	2.303	74	-	-	-
VARS	7407	60	-2.366	2.689	124	TF	Yes	-
[ WDR6 ]	11180	1	-1.334	2.242	22	TF	-	-
MCM3AP	8888	2	-1.683	2.326	52	-	-	-
APLP2	334	15	-2.732	2.389	4	-	Yes	Yes
FOXJ3	22887	15	-2.407	2.369	87	TF	Yes	Yes
AHCTF1	25909	6	-2.069	2.326	31	TF	Yes	-
REXO1	57455	12	-2.303	2.369	130	TF	Yes	-
ZDHHC20	253832	9	-2.673	2.326	25	-	Yes	-
POLR2E	5434	30	-2.037	2.644	201	TF	Yes	-
FUS	2521	11	-1.980	2.414	53	TF	-	-
HNRNPU	3192	39	-2.869	2.644	33	-	Yes	-
GPS1	2873	86	-3.621	2.689	36	TF	Yes	Yes
NOLC1	9221	15	-1.985	2.503	113	TF	-	-
SFPQ	6421	15	-2.051	2.389	142	TF	Yes	-

Interactions (23)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
FUS	2521	RANGAP1	5905	pd	>	reg.ITFP.txt: no annot
POLR2E	5434	RANGAP1	5905	pd	>	reg.ITFP.txt: no annot
PHB	5245	VARS	7407	pd	<	reg.ITFP.txt: no annot
POLR2E	5434	VARS	7407	pd	<>	reg.ITFP.txt: no annot
POLR2E	5434	MCM3AP	8888	pd	>	reg.ITFP.txt: no annot
MCM3AP	8888	REXO1	57455	pd	<	reg.ITFP.txt: no annot
APLP2	334	SFPQ	6421	pd	<	reg.ITFP.txt: no annot
FUS	2521	HNRNPU	3192	pd	>	reg.ITFP.txt: no annot
AHCTF1	25909	ZDHHC20	253832	pd	>	reg.ITFP.txt: no annot
MCM3AP	8888	FOXJ3	22887	pd	<	reg.ITFP.txt: no annot
RANGAP1	5905	WDR6	11180	pd	<	reg.ITFP.txt: no annot
AKT2	208	RANGAP1	5905	pd	>	reg.ITFP.txt: no annot
MCM3AP	8888	WDR6	11180	pd	<	reg.ITFP.txt: no annot
SFPQ	6421	MCM3AP	8888	pd	>	reg.ITFP.txt: no annot
GPS1	2873	PHB	5245	pd	>	reg.ITFP.txt: no annot
RANGAP1	5905	NOLC1	9221	pd	<	reg.ITFP.txt: no annot
FUS	2521	POLR2E	5434	pd	<>	reg.ITFP.txt: no annot
RANGAP1	5905	VARS	7407	pd	<	reg.ITFP.txt: no annot
FOXJ3	22887	REXO1	57455	pd	<>	reg.ITFP.txt: no annot
HNRNPU	3192	POLR2E	5434	pd	<	reg.ITFP.txt: no annot
AKT2	208	MCM3AP	8888	pd	>	reg.ITFP.txt: no annot
AKT2	208	WDR6	11180	pd	<>	reg.ITFP.txt: no annot
MCM3AP	8888	AHCTF1	25909	pd	<	reg.ITFP.txt: no annot

Related GO terms (178)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005643	nuclear pore	8.67e-05	8.46e-01	5.078	3	12	51
GO:0008380	RNA splicing	1.58e-04	1.00e+00	3.800	4	21	165
GO:0005654	nucleoplasm	3.97e-04	1.00e+00	2.199	7	68	876
GO:0008180	COP9 signalosome	7.70e-04	1.00e+00	5.581	2	6	24
GO:0000398	mRNA splicing, via spliceosome	1.31e-03	1.00e+00	3.751	3	15	128
GO:0004832	valine-tRNA ligase activity	1.74e-03	1.00e+00	9.166	1	1	1
GO:0032859	activation of Ral GTPase activity	1.74e-03	1.00e+00	9.166	1	1	1
GO:0006438	valyl-tRNA aminoacylation	1.74e-03	1.00e+00	9.166	1	1	1
GO:0005098	Ran GTPase activator activity	1.74e-03	1.00e+00	9.166	1	1	1
GO:0005634	nucleus	1.81e-03	1.00e+00	1.086	12	158	3246
GO:0051028	mRNA transport	2.95e-03	1.00e+00	4.611	2	5	47
GO:0003677	DNA binding	3.97e-03	1.00e+00	1.864	6	52	947
GO:0000777	condensed chromosome kinetochore	4.30e-03	1.00e+00	4.333	2	6	57
GO:0042826	histone deacetylase binding	4.45e-03	1.00e+00	4.308	2	5	58
GO:0000785	chromatin	4.60e-03	1.00e+00	4.283	2	6	59
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	5.21e-03	1.00e+00	7.581	1	1	3
GO:0046914	transition metal ion binding	5.21e-03	1.00e+00	7.581	1	1	3
GO:0065002	intracellular protein transmembrane transport	5.21e-03	1.00e+00	7.581	1	1	3
GO:0032853	positive regulation of Ran GTPase activity	5.21e-03	1.00e+00	7.581	1	1	3
GO:2001275	positive regulation of glucose import in response to insulin stimulus	5.21e-03	1.00e+00	7.581	1	1	3
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport	6.95e-03	1.00e+00	7.166	1	1	4
GO:0007000	nucleolus organization	6.95e-03	1.00e+00	7.166	1	1	4
GO:0071156	regulation of cell cycle arrest	6.95e-03	1.00e+00	7.166	1	2	4
GO:0007176	regulation of epidermal growth factor-activated receptor activity	6.95e-03	1.00e+00	7.166	1	1	4
GO:0016363	nuclear matrix	6.97e-03	1.00e+00	3.976	2	10	73
GO:0001649	osteoblast differentiation	7.16e-03	1.00e+00	3.956	2	5	74
GO:0032287	peripheral nervous system myelin maintenance	8.68e-03	1.00e+00	6.844	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	8.68e-03	1.00e+00	6.844	1	2	5
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	8.68e-03	1.00e+00	6.844	1	1	5
GO:0002161	aminoacyl-tRNA editing activity	8.68e-03	1.00e+00	6.844	1	1	5
GO:0031340	positive regulation of vesicle fusion	8.68e-03	1.00e+00	6.844	1	1	5
GO:0042382	paraspeckles	8.68e-03	1.00e+00	6.844	1	3	5
GO:0044822	poly(A) RNA binding	9.76e-03	1.00e+00	1.846	5	45	799
GO:0050847	progesterone receptor signaling pathway	1.04e-02	1.00e+00	6.581	1	2	6
GO:0001055	RNA polymerase II activity	1.04e-02	1.00e+00	6.581	1	3	6
GO:0042754	negative regulation of circadian rhythm	1.04e-02	1.00e+00	6.581	1	2	6
GO:0070937	CRD-mediated mRNA stability complex	1.04e-02	1.00e+00	6.581	1	2	6
GO:0046826	negative regulation of protein export from nucleus	1.04e-02	1.00e+00	6.581	1	1	6
GO:0010467	gene expression	1.20e-02	1.00e+00	2.103	4	49	535
GO:0032000	positive regulation of fatty acid beta-oxidation	1.21e-02	1.00e+00	6.359	1	1	7
GO:2000147	positive regulation of cell motility	1.21e-02	1.00e+00	6.359	1	2	7
GO:0007617	mating behavior	1.21e-02	1.00e+00	6.359	1	1	7
GO:0010907	positive regulation of glucose metabolic process	1.21e-02	1.00e+00	6.359	1	1	7
GO:0000380	alternative mRNA splicing, via spliceosome	1.21e-02	1.00e+00	6.359	1	2	7
GO:0006878	cellular copper ion homeostasis	1.38e-02	1.00e+00	6.166	1	1	8
GO:0051292	nuclear pore complex assembly	1.38e-02	1.00e+00	6.166	1	4	8
GO:0006450	regulation of translational fidelity	1.38e-02	1.00e+00	6.166	1	1	8
GO:0010944	negative regulation of transcription by competitive promoter binding	1.38e-02	1.00e+00	6.166	1	1	8
GO:0010388	cullin deneddylation	1.38e-02	1.00e+00	6.166	1	4	8
GO:0031080	nuclear pore outer ring	1.56e-02	1.00e+00	5.996	1	2	9
GO:0090314	positive regulation of protein targeting to membrane	1.56e-02	1.00e+00	5.996	1	2	9
GO:0071354	cellular response to interleukin-6	1.56e-02	1.00e+00	5.996	1	1	9
GO:0060644	mammary gland epithelial cell differentiation	1.56e-02	1.00e+00	5.996	1	1	9
GO:0007049	cell cycle	1.67e-02	1.00e+00	3.320	2	8	115
GO:0001967	suckling behavior	1.73e-02	1.00e+00	5.844	1	4	10
GO:0005736	DNA-directed RNA polymerase I complex	1.73e-02	1.00e+00	5.844	1	4	10
GO:0005095	GTPase inhibitor activity	1.73e-02	1.00e+00	5.844	1	1	10
GO:0010507	negative regulation of autophagy	1.73e-02	1.00e+00	5.844	1	1	10
GO:0001054	RNA polymerase I activity	1.73e-02	1.00e+00	5.844	1	4	10
GO:0008643	carbohydrate transport	1.73e-02	1.00e+00	5.844	1	1	10
GO:0060766	negative regulation of androgen receptor signaling pathway	1.90e-02	1.00e+00	5.707	1	4	11
GO:0045725	positive regulation of glycogen biosynthetic process	1.90e-02	1.00e+00	5.707	1	1	11
GO:0016409	palmitoyltransferase activity	2.07e-02	1.00e+00	5.581	1	1	12
GO:0004527	exonuclease activity	2.07e-02	1.00e+00	5.581	1	4	12
GO:0031965	nuclear membrane	2.10e-02	1.00e+00	3.144	2	8	130
GO:0005666	DNA-directed RNA polymerase III complex	2.24e-02	1.00e+00	5.466	1	3	13
GO:0005665	DNA-directed RNA polymerase II, core complex	2.24e-02	1.00e+00	5.466	1	3	13
GO:0001056	RNA polymerase III activity	2.24e-02	1.00e+00	5.466	1	3	13
GO:0006386	termination of RNA polymerase III transcription	2.41e-02	1.00e+00	5.359	1	3	14
GO:0006385	transcription elongation from RNA polymerase III promoter	2.41e-02	1.00e+00	5.359	1	3	14
GO:0016746	transferase activity, transferring acyl groups	2.41e-02	1.00e+00	5.359	1	2	14
GO:0043393	regulation of protein binding	2.41e-02	1.00e+00	5.359	1	2	14
GO:0016575	histone deacetylation	2.41e-02	1.00e+00	5.359	1	2	14
GO:0044212	transcription regulatory region DNA binding	2.51e-02	1.00e+00	3.006	2	13	143
GO:0005978	glycogen biosynthetic process	2.58e-02	1.00e+00	5.259	1	2	15
GO:0018345	protein palmitoylation	2.58e-02	1.00e+00	5.259	1	1	15
GO:0000188	inactivation of MAPK activity	2.58e-02	1.00e+00	5.259	1	1	15
GO:0070932	histone H3 deacetylation	2.58e-02	1.00e+00	5.259	1	2	15
GO:0019706	protein-cysteine S-palmitoyltransferase activity	2.92e-02	1.00e+00	5.078	1	1	17
GO:0003899	DNA-directed RNA polymerase activity	3.09e-02	1.00e+00	4.996	1	3	18
GO:0036464	cytoplasmic ribonucleoprotein granule	3.26e-02	1.00e+00	4.918	1	1	19
GO:0071897	DNA biosynthetic process	3.43e-02	1.00e+00	4.844	1	2	20
GO:0000166	nucleotide binding	3.68e-02	1.00e+00	2.707	2	13	176
GO:0006606	protein import into nucleus	3.76e-02	1.00e+00	4.707	1	3	22
GO:0046326	positive regulation of glucose import	3.76e-02	1.00e+00	4.707	1	1	22
GO:0002376	immune system process	3.93e-02	1.00e+00	4.642	1	2	23
GO:0006370	7-methylguanosine mRNA capping	4.10e-02	1.00e+00	4.581	1	5	24
GO:0072659	protein localization to plasma membrane	4.10e-02	1.00e+00	4.581	1	1	24
GO:0030901	midbrain development	4.27e-02	1.00e+00	4.522	1	1	25
GO:0000976	transcription regulatory region sequence-specific DNA binding	4.27e-02	1.00e+00	4.522	1	3	25
GO:0006360	transcription from RNA polymerase I promoter	4.60e-02	1.00e+00	4.411	1	4	27
GO:0050885	neuromuscular process controlling balance	4.77e-02	1.00e+00	4.359	1	1	28
GO:0006281	DNA repair	4.77e-02	1.00e+00	2.501	2	24	203
GO:0006418	tRNA aminoacylation for protein translation	4.93e-02	1.00e+00	4.308	1	4	29
GO:0006383	transcription from RNA polymerase III promoter	4.93e-02	1.00e+00	4.308	1	6	29
GO:0042752	regulation of circadian rhythm	4.93e-02	1.00e+00	4.308	1	5	29
GO:0016301	kinase activity	5.10e-02	1.00e+00	4.259	1	2	30
GO:0005515	protein binding	5.22e-02	1.00e+00	0.616	11	198	4124
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5.27e-02	1.00e+00	4.212	1	6	31
GO:0015030	Cajal body	5.43e-02	1.00e+00	4.166	1	3	32
GO:0000910	cytokinesis	5.60e-02	1.00e+00	4.122	1	2	33
GO:0007254	JNK cascade	5.76e-02	1.00e+00	4.078	1	1	34
GO:0050434	positive regulation of viral transcription	5.93e-02	1.00e+00	4.037	1	5	35
GO:0030900	forebrain development	6.09e-02	1.00e+00	3.996	1	2	36
GO:0030334	regulation of cell migration	6.09e-02	1.00e+00	3.996	1	2	36
GO:0045444	fat cell differentiation	6.09e-02	1.00e+00	3.996	1	1	36
GO:0005524	ATP binding	6.30e-02	1.00e+00	1.365	4	37	892
GO:0048511	rhythmic process	6.42e-02	1.00e+00	3.918	1	5	38
GO:0006417	regulation of translation	6.58e-02	1.00e+00	3.881	1	2	39
GO:0006396	RNA processing	6.75e-02	1.00e+00	3.844	1	4	40
GO:0006283	transcription-coupled nucleotide-excision repair	6.75e-02	1.00e+00	3.844	1	6	40
GO:0003723	RNA binding	6.75e-02	1.00e+00	2.218	2	22	247
GO:0004867	serine-type endopeptidase inhibitor activity	7.07e-02	1.00e+00	3.774	1	1	42
GO:0001047	core promoter binding	7.07e-02	1.00e+00	3.774	1	4	42
GO:0005829	cytosol	7.42e-02	1.00e+00	0.948	6	88	1787
GO:0032869	cellular response to insulin stimulus	7.88e-02	1.00e+00	3.611	1	2	47
GO:0008203	cholesterol metabolic process	7.88e-02	1.00e+00	3.611	1	2	47
GO:0007626	locomotory behavior	7.88e-02	1.00e+00	3.611	1	1	47
GO:0032481	positive regulation of type I interferon production	8.04e-02	1.00e+00	3.581	1	3	48
GO:0008285	negative regulation of cell proliferation	8.25e-02	1.00e+00	2.052	2	11	277
GO:0032587	ruffle membrane	8.36e-02	1.00e+00	3.522	1	3	50
GO:0006310	DNA recombination	8.36e-02	1.00e+00	3.522	1	8	50
GO:0006368	transcription elongation from RNA polymerase II promoter	8.68e-02	1.00e+00	3.466	1	8	52
GO:0006289	nucleotide-excision repair	8.84e-02	1.00e+00	3.438	1	6	53
GO:0007165	signal transduction	8.85e-02	1.00e+00	1.479	3	24	618
GO:0000776	kinetochore	9.16e-02	1.00e+00	3.385	1	8	55
GO:0071013	catalytic step 2 spliceosome	1.01e-01	1.00e+00	3.235	1	5	61
GO:0006464	cellular protein modification process	1.01e-01	1.00e+00	3.235	1	4	61
GO:0000278	mitotic cell cycle	1.02e-01	1.00e+00	1.871	2	28	314
GO:0045892	negative regulation of transcription, DNA-templated	1.04e-01	1.00e+00	1.858	2	17	317
GO:0003676	nucleic acid binding	1.09e-01	1.00e+00	3.122	1	4	66
GO:0006364	rRNA processing	1.11e-01	1.00e+00	3.100	1	2	67
GO:0000922	spindle pole	1.12e-01	1.00e+00	3.078	1	4	68
GO:0030308	negative regulation of cell growth	1.15e-01	1.00e+00	3.037	1	3	70
GO:0010951	negative regulation of endopeptidase activity	1.17e-01	1.00e+00	3.016	1	2	71
GO:0006355	regulation of transcription, DNA-templated	1.24e-01	1.00e+00	1.269	3	31	715
GO:0042802	identical protein binding	1.25e-01	1.00e+00	1.698	2	15	354
GO:0005938	cell cortex	1.26e-01	1.00e+00	2.899	1	6	77
GO:0006006	glucose metabolic process	1.31e-01	1.00e+00	2.844	1	3	80
GO:0030529	ribonucleoprotein complex	1.34e-01	1.00e+00	2.808	1	5	82
GO:0001934	positive regulation of protein phosphorylation	1.35e-01	1.00e+00	2.791	1	1	83
GO:0061024	membrane organization	1.44e-01	1.00e+00	2.690	1	2	89
GO:0005737	cytoplasm	1.47e-01	1.00e+00	0.611	7	127	2633
GO:0008201	heparin binding	1.47e-01	1.00e+00	2.658	1	4	91
GO:0007050	cell cycle arrest	1.49e-01	1.00e+00	2.642	1	4	92
GO:0016020	membrane	1.50e-01	1.00e+00	0.929	4	56	1207
GO:0006260	DNA replication	1.52e-01	1.00e+00	2.611	1	9	94
GO:0008286	insulin receptor signaling pathway	1.56e-01	1.00e+00	2.566	1	2	97
GO:0006397	mRNA processing	1.75e-01	1.00e+00	2.385	1	12	110
GO:0042981	regulation of apoptotic process	1.78e-01	1.00e+00	2.359	1	4	112
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	1.87e-01	1.00e+00	1.333	2	29	456
GO:0006367	transcription initiation from RNA polymerase II promoter	2.46e-01	1.00e+00	1.835	1	18	161
GO:0007067	mitotic nuclear division	2.52e-01	1.00e+00	1.800	1	9	165
GO:0003700	sequence-specific DNA binding transcription factor activity	2.69e-01	1.00e+00	0.981	2	22	582
GO:0005743	mitochondrial inner membrane	2.93e-01	1.00e+00	1.544	1	9	197
GO:0004674	protein serine/threonine kinase activity	2.93e-01	1.00e+00	1.544	1	8	197
GO:0005525	GTP binding	2.93e-01	1.00e+00	1.544	1	12	197
GO:0015031	protein transport	3.01e-01	1.00e+00	1.501	1	10	203
GO:0019899	enzyme binding	3.09e-01	1.00e+00	1.452	1	7	210
GO:0005739	mitochondrion	3.20e-01	1.00e+00	0.802	2	32	659
GO:0030198	extracellular matrix organization	3.23e-01	1.00e+00	1.378	1	7	221
GO:0007186	G-protein coupled receptor signaling pathway	3.32e-01	1.00e+00	1.327	1	4	229
GO:0005730	nucleolus	3.57e-01	1.00e+00	0.502	3	74	1217
GO:0008270	zinc ion binding	3.65e-01	1.00e+00	0.660	2	39	727
GO:0005886	plasma membrane	3.78e-01	1.00e+00	0.365	4	46	1784
GO:0043565	sequence-specific DNA binding	3.85e-01	1.00e+00	1.063	1	8	275
GO:0009986	cell surface	4.02e-01	1.00e+00	0.981	1	5	291
GO:0006468	protein phosphorylation	4.13e-01	1.00e+00	0.932	1	6	301
GO:0006366	transcription from RNA polymerase II promoter	4.54e-01	1.00e+00	0.752	1	23	341
GO:0048471	perinuclear region of cytoplasm	4.57e-01	1.00e+00	0.740	1	11	344
GO:0045893	positive regulation of transcription, DNA-templated	4.88e-01	1.00e+00	0.608	1	21	377
GO:0006915	apoptotic process	5.19e-01	1.00e+00	0.483	1	15	411
GO:0016032	viral process	5.34e-01	1.00e+00	0.424	1	30	428
GO:0045087	innate immune response	5.54e-01	1.00e+00	0.346	1	12	452
GO:0070062	extracellular vesicular exosome	5.63e-01	1.00e+00	0.071	3	51	1641
GO:0006351	transcription, DNA-templated	5.73e-01	1.00e+00	0.094	2	47	1076
GO:0005887	integral component of plasma membrane	6.44e-01	1.00e+00	-0.001	1	8	575
GO:0016021	integral component of membrane	7.69e-01	1.00e+00	-0.410	2	19	1526

chia-Fav

reg-snw-11180

Statistics

Genes (17)

Interactions (23)

Related GO terms (178)