reg-snw-10617

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.212	2.49e-07	4.34e-02	3.30e-02

chia-screen-data-Fav-reg-snw-10617 subnetwork

Genes (15)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Transcription factor	Chia-Hits Primary	Chia-Hits Secondary
TDP1	55775	5	-1.669	2.428	52	-	-	-
KARS	3735	12	-1.759	2.428	123	TF	-	-
EIF2S2	8894	40	-2.999	2.459	22	-	Yes	Yes
FBXL6	26233	28	-2.253	2.689	22	-	Yes	-
CENPA	1058	27	-2.185	2.393	205	TF	Yes	-
SYNCRIP	10492	42	-2.401	2.503	144	TF	Yes	Yes
[ STAMBP ]	10617	1	-1.217	2.212	3	-	-	-
PHB2	11331	17	-2.236	2.449	11	-	Yes	-
RAE1	8480	7	-1.501	2.342	204	TF	-	-
PHB	5245	82	-2.743	2.689	36	-	Yes	Yes
GSPT1	2935	32	-2.313	2.503	17	-	Yes	Yes
GTF3C3	9330	5	-1.450	2.428	62	TF	-	-
CPSF3	51692	43	-2.686	2.503	31	-	Yes	Yes
GUCY1A3	2982	4	-2.148	2.345	19	-	Yes	-
GPS1	2873	86	-3.621	2.689	36	TF	Yes	Yes

Interactions (20)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
GUCY1A3	2982	RAE1	8480	pd	<	reg.ITFP.txt: no annot
CENPA	1058	FBXL6	26233	pd	>	reg.ITFP.txt: no annot
KARS	3735	GTF3C3	9330	pd	<>	reg.ITFP.txt: no annot
CENPA	1058	RAE1	8480	pd	<>	reg.ITFP.txt: no annot
GPS1	2873	PHB	5245	pd	>	reg.ITFP.txt: no annot
RAE1	8480	TDP1	55775	pd	>	reg.ITFP.txt: no annot
CENPA	1058	KARS	3735	pd	<>	reg.ITFP.txt: no annot
KARS	3735	PHB2	11331	pd	>	reg.ITFP.txt: no annot
KARS	3735	PHB	5245	pd	>	reg.ITFP.txt: no annot
RAE1	8480	CPSF3	51692	pd	>	reg.ITFP.txt: no annot
SYNCRIP	10492	TDP1	55775	pd	>	reg.ITFP.txt: no annot
SYNCRIP	10492	CPSF3	51692	pd	>	reg.ITFP.txt: no annot
GPS1	2873	PHB2	11331	pd	>	reg.ITFP.txt: no annot
GTF3C3	9330	TDP1	55775	pd	>	reg.ITFP.txt: no annot
EIF2S2	8894	GTF3C3	9330	pd	<	reg.ITFP.txt: no annot
GTF3C3	9330	STAMBP	10617	pd	>	reg.ITFP.txt: no annot
RAE1	8480	FBXL6	26233	pd	>	reg.ITFP.txt: no annot
GSPT1	2935	SYNCRIP	10492	pd	<	reg.ITFP.txt: no annot
GSPT1	2935	KARS	3735	pd	<	reg.ITFP.txt: no annot
RAE1	8480	GTF3C3	9330	pd	<>	reg.ITFP.txt: no annot

Related GO terms (172)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0003723	RNA binding	4.38e-04	1.00e+00	3.398	4	22	247
GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	1.54e-03	1.00e+00	9.347	1	1	1
GO:0052565	response to defense-related host nitric oxide production	1.54e-03	1.00e+00	9.347	1	1	1
GO:0006430	lysyl-tRNA aminoacylation	1.54e-03	1.00e+00	9.347	1	1	1
GO:0004824	lysine-tRNA ligase activity	1.54e-03	1.00e+00	9.347	1	1	1
GO:0000939	condensed chromosome inner kinetochore	1.54e-03	1.00e+00	9.347	1	1	1
GO:0006406	mRNA export from nucleus	2.01e-03	1.00e+00	4.887	2	7	44
GO:0008074	guanylate cyclase complex, soluble	3.07e-03	1.00e+00	8.347	1	1	2
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	3.07e-03	1.00e+00	8.347	1	1	2
GO:0003747	translation release factor activity	3.07e-03	1.00e+00	8.347	1	2	2
GO:0015966	diadenosine tetraphosphate biosynthetic process	3.07e-03	1.00e+00	8.347	1	1	2
GO:0002176	male germ cell proliferation	3.07e-03	1.00e+00	8.347	1	1	2
GO:0005515	protein binding	3.33e-03	1.00e+00	0.922	12	198	4124
GO:0016032	viral process	3.38e-03	1.00e+00	2.605	4	30	428
GO:0005850	eukaryotic translation initiation factor 2 complex	4.60e-03	1.00e+00	7.762	1	2	3
GO:0000778	condensed nuclear chromosome kinetochore	4.60e-03	1.00e+00	7.762	1	2	3
GO:0071459	protein localization to chromosome, centromeric region	4.60e-03	1.00e+00	7.762	1	1	3
GO:0001649	osteoblast differentiation	5.58e-03	1.00e+00	4.137	2	5	74
GO:0097452	GAIT complex	6.13e-03	1.00e+00	7.347	1	2	4
GO:0030828	positive regulation of cGMP biosynthetic process	6.13e-03	1.00e+00	7.347	1	1	4
GO:0000012	single strand break repair	6.13e-03	1.00e+00	7.347	1	1	4
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	6.13e-03	1.00e+00	7.347	1	1	4
GO:0030529	ribonucleoprotein complex	6.81e-03	1.00e+00	3.989	2	5	82
GO:0010467	gene expression	7.49e-03	1.00e+00	2.283	4	49	535
GO:0060087	relaxation of vascular smooth muscle	7.66e-03	1.00e+00	7.025	1	1	5
GO:0004521	endoribonuclease activity	7.66e-03	1.00e+00	7.025	1	1	5
GO:0042797	tRNA transcription from RNA polymerase III promoter	7.66e-03	1.00e+00	7.025	1	3	5
GO:0006398	histone mRNA 3'-end processing	7.66e-03	1.00e+00	7.025	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	7.66e-03	1.00e+00	7.025	1	2	5
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	7.66e-03	1.00e+00	7.025	1	1	5
GO:0060744	mammary gland branching involved in thelarche	7.66e-03	1.00e+00	7.025	1	1	5
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	7.66e-03	1.00e+00	7.025	1	1	5
GO:0071204	histone pre-mRNA 3'end processing complex	7.66e-03	1.00e+00	7.025	1	1	5
GO:0000127	transcription factor TFIIIC complex	7.66e-03	1.00e+00	7.025	1	3	5
GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter	7.66e-03	1.00e+00	7.025	1	3	5
GO:0005654	nucleoplasm	8.04e-03	1.00e+00	1.894	5	68	876
GO:0050847	progesterone receptor signaling pathway	9.18e-03	1.00e+00	6.762	1	2	6
GO:0004383	guanylate cyclase activity	9.18e-03	1.00e+00	6.762	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	9.18e-03	1.00e+00	6.762	1	2	6
GO:0008409	5'-3' exonuclease activity	1.07e-02	1.00e+00	6.539	1	2	7
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	1.07e-02	1.00e+00	6.539	1	2	7
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	1.07e-02	1.00e+00	6.539	1	1	7
GO:0000780	condensed nuclear chromosome, centromeric region	1.07e-02	1.00e+00	6.539	1	1	7
GO:0051382	kinetochore assembly	1.07e-02	1.00e+00	6.539	1	2	7
GO:0010944	negative regulation of transcription by competitive promoter binding	1.22e-02	1.00e+00	6.347	1	1	8
GO:0010388	cullin deneddylation	1.22e-02	1.00e+00	6.347	1	4	8
GO:0006379	mRNA cleavage	1.37e-02	1.00e+00	6.177	1	2	9
GO:0071354	cellular response to interleukin-6	1.37e-02	1.00e+00	6.177	1	1	9
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	1.37e-02	1.00e+00	6.177	1	3	9
GO:0005095	GTPase inhibitor activity	1.53e-02	1.00e+00	6.025	1	1	10
GO:0006182	cGMP biosynthetic process	1.53e-02	1.00e+00	6.025	1	1	10
GO:0008143	poly(A) binding	1.53e-02	1.00e+00	6.025	1	2	10
GO:0000398	mRNA splicing, via spliceosome	1.60e-02	1.00e+00	3.347	2	15	128
GO:0060766	negative regulation of androgen receptor signaling pathway	1.68e-02	1.00e+00	5.887	1	4	11
GO:0006479	protein methylation	1.68e-02	1.00e+00	5.887	1	2	11
GO:0000132	establishment of mitotic spindle orientation	1.83e-02	1.00e+00	5.762	1	2	12
GO:0004527	exonuclease activity	1.83e-02	1.00e+00	5.762	1	4	12
GO:0007263	nitric oxide mediated signal transduction	1.83e-02	1.00e+00	5.762	1	1	12
GO:0060749	mammary gland alveolus development	1.98e-02	1.00e+00	5.646	1	1	13
GO:0046580	negative regulation of Ras protein signal transduction	2.13e-02	1.00e+00	5.539	1	1	14
GO:0016597	amino acid binding	2.13e-02	1.00e+00	5.539	1	1	14
GO:0016575	histone deacetylation	2.13e-02	1.00e+00	5.539	1	2	14
GO:0008135	translation factor activity, nucleic acid binding	2.28e-02	1.00e+00	5.440	1	4	15
GO:0000188	inactivation of MAPK activity	2.28e-02	1.00e+00	5.440	1	1	15
GO:0000281	mitotic cytokinesis	2.28e-02	1.00e+00	5.440	1	3	15
GO:0005640	nuclear outer membrane	2.58e-02	1.00e+00	5.259	1	1	17
GO:0008380	RNA splicing	2.58e-02	1.00e+00	2.980	2	21	165
GO:0006378	mRNA polyadenylation	2.73e-02	1.00e+00	5.177	1	3	18
GO:0005634	nucleus	3.02e-02	1.00e+00	0.852	9	158	3246
GO:0034080	CENP-A containing nucleosome assembly	3.03e-02	1.00e+00	5.025	1	2	20
GO:0071346	cellular response to interferon-gamma	3.03e-02	1.00e+00	5.025	1	2	20
GO:0071897	DNA biosynthetic process	3.03e-02	1.00e+00	5.025	1	2	20
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	3.18e-02	1.00e+00	4.954	1	2	21
GO:0030331	estrogen receptor binding	3.33e-02	1.00e+00	4.887	1	2	22
GO:0000049	tRNA binding	3.48e-02	1.00e+00	4.823	1	2	23
GO:0005743	mitochondrial inner membrane	3.58e-02	1.00e+00	2.724	2	9	197
GO:0005525	GTP binding	3.58e-02	1.00e+00	2.724	2	12	197
GO:0008180	COP9 signalosome	3.63e-02	1.00e+00	4.762	1	6	24
GO:0008033	tRNA processing	3.77e-02	1.00e+00	4.703	1	2	25
GO:0007259	JAK-STAT cascade	3.77e-02	1.00e+00	4.703	1	2	25
GO:0010827	regulation of glucose transport	3.77e-02	1.00e+00	4.703	1	7	25
GO:0006418	tRNA aminoacylation for protein translation	4.37e-02	1.00e+00	4.489	1	4	29
GO:0006383	transcription from RNA polymerase III promoter	4.37e-02	1.00e+00	4.489	1	6	29
GO:0016579	protein deubiquitination	4.37e-02	1.00e+00	4.489	1	1	29
GO:0032154	cleavage furrow	4.51e-02	1.00e+00	4.440	1	3	30
GO:0090305	nucleic acid phosphodiester bond hydrolysis	4.66e-02	1.00e+00	4.392	1	6	31
GO:0008015	blood circulation	4.66e-02	1.00e+00	4.392	1	1	31
GO:0007077	mitotic nuclear envelope disassembly	4.81e-02	1.00e+00	4.347	1	9	32
GO:0046872	metal ion binding	4.83e-02	1.00e+00	1.479	4	24	934
GO:0017148	negative regulation of translation	4.95e-02	1.00e+00	4.302	1	5	33
GO:0000786	nucleosome	5.10e-02	1.00e+00	4.259	1	2	34
GO:0071407	cellular response to organic cyclic compound	5.10e-02	1.00e+00	4.259	1	2	34
GO:0007254	JNK cascade	5.10e-02	1.00e+00	4.259	1	1	34
GO:0031124	mRNA 3'-end processing	5.25e-02	1.00e+00	4.217	1	4	35
GO:0008645	hexose transport	5.39e-02	1.00e+00	4.177	1	8	36
GO:0003743	translation initiation factor activity	5.54e-02	1.00e+00	4.137	1	8	37
GO:0008237	metallopeptidase activity	5.68e-02	1.00e+00	4.099	1	3	38
GO:0006369	termination of RNA polymerase II transcription	5.68e-02	1.00e+00	4.099	1	5	38
GO:0006396	RNA processing	5.98e-02	1.00e+00	4.025	1	4	40
GO:0006508	proteolysis	6.07e-02	1.00e+00	2.302	2	11	264
GO:0000775	chromosome, centromeric region	6.12e-02	1.00e+00	3.989	1	6	41
GO:0008217	regulation of blood pressure	6.27e-02	1.00e+00	3.954	1	2	42
GO:0004843	ubiquitin-specific protease activity	6.84e-02	1.00e+00	3.823	1	2	46
GO:0015758	glucose transport	7.13e-02	1.00e+00	3.762	1	8	48
GO:0006334	nucleosome assembly	7.56e-02	1.00e+00	3.674	1	4	51
GO:0005643	nuclear pore	7.56e-02	1.00e+00	3.674	1	12	51
GO:0005739	mitochondrion	7.58e-02	1.00e+00	1.567	3	32	659
GO:0006302	double-strand break repair	7.70e-02	1.00e+00	3.646	1	5	52
GO:0000278	mitotic cell cycle	8.22e-02	1.00e+00	2.052	2	28	314
GO:0045892	negative regulation of transcription, DNA-templated	8.35e-02	1.00e+00	2.038	2	17	317
GO:0008584	male gonad development	8.41e-02	1.00e+00	3.514	1	1	57
GO:0003697	single-stranded DNA binding	8.41e-02	1.00e+00	3.514	1	4	57
GO:0042826	histone deacetylase binding	8.55e-02	1.00e+00	3.489	1	5	58
GO:0071013	catalytic step 2 spliceosome	8.98e-02	1.00e+00	3.416	1	5	61
GO:0006415	translational termination	9.26e-02	1.00e+00	3.369	1	2	63
GO:0030308	negative regulation of cell growth	1.02e-01	1.00e+00	3.217	1	3	70
GO:0016363	nuclear matrix	1.07e-01	1.00e+00	3.157	1	10	73
GO:0015630	microtubule cytoskeleton	1.09e-01	1.00e+00	3.118	1	5	75
GO:0044822	poly(A) RNA binding	1.19e-01	1.00e+00	1.289	3	45	799
GO:0003690	double-stranded DNA binding	1.20e-01	1.00e+00	2.971	1	6	83
GO:0005635	nuclear envelope	1.20e-01	1.00e+00	2.971	1	6	83
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1.22e-01	1.00e+00	2.954	1	5	84
GO:0043524	negative regulation of neuron apoptotic process	1.23e-01	1.00e+00	2.937	1	2	85
GO:0020037	heme binding	1.27e-01	1.00e+00	2.887	1	3	88
GO:0008017	microtubule binding	1.39e-01	1.00e+00	2.747	1	9	97
GO:0006413	translational initiation	1.42e-01	1.00e+00	2.717	1	6	99
GO:0005769	early endosome	1.55e-01	1.00e+00	2.578	1	3	109
GO:0042981	regulation of apoptotic process	1.59e-01	1.00e+00	2.539	1	4	112
GO:0007049	cell cycle	1.63e-01	1.00e+00	2.501	1	8	115
GO:0004872	receptor activity	1.64e-01	1.00e+00	2.489	1	4	116
GO:0003924	GTPase activity	1.68e-01	1.00e+00	2.452	1	7	119
GO:0000082	G1/S transition of mitotic cell cycle	1.76e-01	1.00e+00	2.381	1	4	125
GO:0006184	GTP catabolic process	1.82e-01	1.00e+00	2.324	1	7	130
GO:0005759	mitochondrial matrix	1.94e-01	1.00e+00	2.228	1	7	139
GO:0005737	cytoplasm	1.95e-01	1.00e+00	0.569	6	127	2633
GO:0044212	transcription regulatory region DNA binding	1.99e-01	1.00e+00	2.187	1	13	143
GO:0005622	intracellular	2.01e-01	1.00e+00	2.167	1	2	145
GO:0001701	in utero embryonic development	2.12e-01	1.00e+00	2.080	1	7	154
GO:0019221	cytokine-mediated signaling pathway	2.34e-01	1.00e+00	1.920	1	10	172
GO:0000166	nucleotide binding	2.39e-01	1.00e+00	1.887	1	13	176
GO:0006412	translation	2.41e-01	1.00e+00	1.871	1	12	178
GO:0004842	ubiquitin-protein transferase activity	2.42e-01	1.00e+00	1.863	1	17	179
GO:0005975	carbohydrate metabolic process	2.51e-01	1.00e+00	1.807	1	10	186
GO:0016567	protein ubiquitination	2.53e-01	1.00e+00	1.792	1	14	188
GO:0005856	cytoskeleton	2.55e-01	1.00e+00	1.777	1	8	190
GO:0006281	DNA repair	2.70e-01	1.00e+00	1.681	1	24	203
GO:0043234	protein complex	2.78e-01	1.00e+00	1.632	1	13	210
GO:0019899	enzyme binding	2.78e-01	1.00e+00	1.632	1	7	210
GO:0003682	chromatin binding	3.25e-01	1.00e+00	1.369	1	15	252
GO:0046982	protein heterodimerization activity	3.38e-01	1.00e+00	1.297	1	11	265
GO:0008285	negative regulation of cell proliferation	3.51e-01	1.00e+00	1.233	1	11	277
GO:0008284	positive regulation of cell proliferation	3.53e-01	1.00e+00	1.222	1	8	279
GO:0055085	transmembrane transport	4.02e-01	1.00e+00	0.985	1	13	329
GO:0007596	blood coagulation	4.12e-01	1.00e+00	0.941	1	13	339
GO:0006366	transcription from RNA polymerase II promoter	4.13e-01	1.00e+00	0.933	1	23	341
GO:0044267	cellular protein metabolic process	4.24e-01	1.00e+00	0.887	1	14	352
GO:0003677	DNA binding	4.35e-01	1.00e+00	0.459	2	52	947
GO:0045893	positive regulation of transcription, DNA-templated	4.46e-01	1.00e+00	0.788	1	21	377
GO:0005783	endoplasmic reticulum	4.50e-01	1.00e+00	0.773	1	12	381
GO:0070062	extracellular vesicular exosome	4.74e-01	1.00e+00	0.251	3	51	1641
GO:0006351	transcription, DNA-templated	5.04e-01	1.00e+00	0.275	2	47	1076
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	5.12e-01	1.00e+00	0.514	1	29	456
GO:0005829	cytosol	5.36e-01	1.00e+00	0.128	3	88	1787
GO:0016020	membrane	5.70e-01	1.00e+00	0.109	2	56	1207
GO:0005730	nucleolus	5.74e-01	1.00e+00	0.097	2	74	1217
GO:0005887	integral component of plasma membrane	5.98e-01	1.00e+00	0.179	1	8	575
GO:0007165	signal transduction	6.25e-01	1.00e+00	0.075	1	24	618
GO:0005576	extracellular region	6.52e-01	1.00e+00	-0.026	1	15	663
GO:0006355	regulation of transcription, DNA-templated	6.81e-01	1.00e+00	-0.135	1	31	715
GO:0044281	small molecule metabolic process	7.43e-01	1.00e+00	-0.375	1	35	844
GO:0005524	ATP binding	7.63e-01	1.00e+00	-0.454	1	37	892
GO:0005886	plasma membrane	7.89e-01	1.00e+00	-0.454	2	46	1784

chia-Fav

reg-snw-10617

Statistics

Genes (15)

Interactions (20)

Related GO terms (172)