int-snw-9968

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.206	8.77e-20	2.72e-06	8.57e-05

chia-screen-data-Fav-int-snw-9968 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
[ MED12 ]	9968	14	-2.465	3.206	65	Yes	-
MED19	219541	30	-2.657	3.449	115	Yes	-
APLP2	334	12	-2.732	3.206	35	Yes	Yes
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
LUC7L3	51747	33	-3.523	3.449	18	Yes	-

Interactions (7)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
APLP2	334	MED12	9968	pp	--	int.I2D: MINT; int.Mint: MI:0407(direct interaction)
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HCFC1	3054	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
MED12	9968	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct

Related GO terms (121)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006366	transcription from RNA polymerase II promoter	2.29e-05	3.31e-01	4.298	4	30	419
GO:0001104	RNA polymerase II transcription cofactor activity	1.06e-04	1.00e+00	6.964	2	8	33
GO:0016592	mediator complex	1.19e-04	1.00e+00	6.879	2	10	35
GO:0060795	cell fate commitment involved in formation of primary germ layer	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	4.85e-04	1.00e+00	11.009	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	4.85e-04	1.00e+00	11.009	1	1	1
GO:0005654	nucleoplasm	9.17e-04	1.00e+00	2.929	4	64	1082
GO:0019046	release from viral latency	9.70e-04	1.00e+00	10.009	1	2	2
GO:0009786	regulation of asymmetric cell division	9.70e-04	1.00e+00	10.009	1	1	2
GO:0060913	cardiac cell fate determination	1.46e-03	1.00e+00	9.424	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.46e-03	1.00e+00	9.424	1	1	3
GO:0090245	axis elongation involved in somitogenesis	1.46e-03	1.00e+00	9.424	1	1	3
GO:0046914	transition metal ion binding	1.46e-03	1.00e+00	9.424	1	1	3
GO:0014044	Schwann cell development	1.94e-03	1.00e+00	9.009	1	1	4
GO:0001714	endodermal cell fate specification	2.42e-03	1.00e+00	8.687	1	1	5
GO:0070461	SAGA-type complex	2.42e-03	1.00e+00	8.687	1	2	5
GO:0007176	regulation of epidermal growth factor-activated receptor activity	2.42e-03	1.00e+00	8.687	1	1	5
GO:0016607	nuclear speck	2.85e-03	1.00e+00	4.582	2	12	172
GO:0070688	MLL5-L complex	3.88e-03	1.00e+00	8.009	1	1	8
GO:0043254	regulation of protein complex assembly	3.88e-03	1.00e+00	8.009	1	1	8
GO:0007617	mating behavior	3.88e-03	1.00e+00	8.009	1	1	8
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	4.36e-03	1.00e+00	7.839	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	4.36e-03	1.00e+00	7.839	1	5	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	4.36e-03	1.00e+00	7.839	1	5	9
GO:0048188	Set1C/COMPASS complex	4.36e-03	1.00e+00	7.839	1	4	9
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	4.83e-03	1.00e+00	2.970	3	41	789
GO:0035413	positive regulation of catenin import into nucleus	4.84e-03	1.00e+00	7.687	1	2	10
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	4.84e-03	1.00e+00	7.687	1	1	10
GO:0008380	RNA splicing	4.96e-03	1.00e+00	4.176	2	22	228
GO:0005634	nucleus	5.08e-03	1.00e+00	1.439	6	159	4559
GO:0060391	positive regulation of SMAD protein import into nucleus	5.33e-03	1.00e+00	7.549	1	4	11
GO:0003713	transcription coactivator activity	5.35e-03	1.00e+00	4.120	2	24	237
GO:0006878	cellular copper ion homeostasis	5.81e-03	1.00e+00	7.424	1	1	12
GO:0035198	miRNA binding	5.81e-03	1.00e+00	7.424	1	1	12
GO:0042789	mRNA transcription from RNA polymerase II promoter	6.29e-03	1.00e+00	7.308	1	2	13
GO:0005685	U1 snRNP	6.78e-03	1.00e+00	7.201	1	1	14
GO:0001967	suckling behavior	6.78e-03	1.00e+00	7.201	1	1	14
GO:0030518	intracellular steroid hormone receptor signaling pathway	6.78e-03	1.00e+00	7.201	1	6	14
GO:0043981	histone H4-K5 acetylation	7.26e-03	1.00e+00	7.102	1	5	15
GO:0042809	vitamin D receptor binding	7.26e-03	1.00e+00	7.102	1	6	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	7.26e-03	1.00e+00	7.102	1	3	15
GO:0006376	mRNA splice site selection	7.26e-03	1.00e+00	7.102	1	1	15
GO:0001824	blastocyst development	7.26e-03	1.00e+00	7.102	1	2	15
GO:0043982	histone H4-K8 acetylation	7.26e-03	1.00e+00	7.102	1	5	15
GO:0043274	phospholipase binding	7.74e-03	1.00e+00	7.009	1	1	16
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	7.74e-03	1.00e+00	7.009	1	2	16
GO:0043984	histone H4-K16 acetylation	9.19e-03	1.00e+00	6.761	1	5	19
GO:0014003	oligodendrocyte development	9.67e-03	1.00e+00	6.687	1	5	20
GO:0043393	regulation of protein binding	9.67e-03	1.00e+00	6.687	1	1	20
GO:0003682	chromatin binding	9.98e-03	1.00e+00	3.656	2	19	327
GO:0000123	histone acetyltransferase complex	1.01e-02	1.00e+00	6.616	1	6	21
GO:0045787	positive regulation of cell cycle	1.06e-02	1.00e+00	6.549	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.06e-02	1.00e+00	6.549	1	4	22
GO:0044822	poly(A) RNA binding	1.10e-02	1.00e+00	2.549	3	50	1056
GO:0046966	thyroid hormone receptor binding	1.26e-02	1.00e+00	6.308	1	6	26
GO:0071339	MLL1 complex	1.30e-02	1.00e+00	6.254	1	6	27
GO:0030901	midbrain development	1.40e-02	1.00e+00	6.151	1	1	29
GO:0003677	DNA binding	1.62e-02	1.00e+00	2.343	3	49	1218
GO:0030178	negative regulation of Wnt signaling pathway	1.69e-02	1.00e+00	5.879	1	4	35
GO:0035019	somatic stem cell maintenance	1.93e-02	1.00e+00	5.687	1	6	40
GO:0050885	neuromuscular process controlling balance	1.93e-02	1.00e+00	5.687	1	2	40
GO:0030521	androgen receptor signaling pathway	1.97e-02	1.00e+00	5.651	1	5	41
GO:0031124	mRNA 3'-end processing	2.02e-02	1.00e+00	5.616	1	2	42
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	2.07e-02	1.00e+00	5.582	1	7	43
GO:0042802	identical protein binding	2.11e-02	1.00e+00	3.090	2	19	484
GO:0003712	transcription cofactor activity	2.12e-02	1.00e+00	5.549	1	8	44
GO:0006369	termination of RNA polymerase II transcription	2.16e-02	1.00e+00	5.517	1	2	45
GO:0019827	stem cell maintenance	2.26e-02	1.00e+00	5.454	1	7	47
GO:0030900	forebrain development	2.35e-02	1.00e+00	5.394	1	1	49
GO:0005515	protein binding	2.38e-02	1.00e+00	1.037	6	198	6024
GO:0009611	response to wounding	2.50e-02	1.00e+00	5.308	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.54e-02	1.00e+00	5.281	1	5	53
GO:0008203	cholesterol metabolic process	2.73e-02	1.00e+00	5.176	1	2	57
GO:0008013	beta-catenin binding	2.88e-02	1.00e+00	5.102	1	9	60
GO:0006406	mRNA export from nucleus	2.92e-02	1.00e+00	5.078	1	4	61
GO:0004867	serine-type endopeptidase inhibitor activity	3.02e-02	1.00e+00	5.031	1	3	63
GO:0010468	regulation of gene expression	3.25e-02	1.00e+00	4.921	1	2	68
GO:0007626	locomotory behavior	3.40e-02	1.00e+00	4.859	1	2	71
GO:0003729	mRNA binding	3.44e-02	1.00e+00	4.839	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	3.54e-02	1.00e+00	4.799	1	4	74
GO:0001843	neural tube closure	3.54e-02	1.00e+00	4.799	1	2	74
GO:0060070	canonical Wnt signaling pathway	3.58e-02	1.00e+00	4.780	1	4	75
GO:0016020	membrane	3.85e-02	1.00e+00	1.879	3	46	1681
GO:0010467	gene expression	3.86e-02	1.00e+00	2.623	2	45	669
GO:0009653	anatomical structure morphogenesis	3.96e-02	1.00e+00	4.634	1	2	83
GO:0003700	sequence-specific DNA binding transcription factor activity	4.19e-02	1.00e+00	2.560	2	39	699
GO:0050821	protein stabilization	4.19e-02	1.00e+00	4.549	1	3	88
GO:0010951	negative regulation of endopeptidase activity	4.94e-02	1.00e+00	4.308	1	6	104
GO:0006325	chromatin organization	5.59e-02	1.00e+00	4.126	1	12	118
GO:0008201	heparin binding	5.77e-02	1.00e+00	4.078	1	1	122
GO:0007507	heart development	6.56e-02	1.00e+00	3.890	1	7	139
GO:0010628	positive regulation of gene expression	6.88e-02	1.00e+00	3.819	1	7	146
GO:0008022	protein C-terminus binding	7.56e-02	1.00e+00	3.678	1	8	161
GO:0000398	mRNA splicing, via spliceosome	7.69e-02	1.00e+00	3.651	1	15	164
GO:0044212	transcription regulatory region DNA binding	7.88e-02	1.00e+00	3.616	1	17	168
GO:0006355	regulation of transcription, DNA-templated	7.95e-02	1.00e+00	2.047	2	43	997
GO:0007049	cell cycle	8.15e-02	1.00e+00	3.566	1	6	174
GO:0005667	transcription factor complex	8.19e-02	1.00e+00	3.558	1	17	175
GO:0031625	ubiquitin protein ligase binding	8.33e-02	1.00e+00	3.533	1	5	178
GO:0019904	protein domain specific binding	8.37e-02	1.00e+00	3.525	1	8	179
GO:0006367	transcription initiation from RNA polymerase II promoter	8.60e-02	1.00e+00	3.485	1	22	184
GO:0004872	receptor activity	8.82e-02	1.00e+00	3.446	1	8	189
GO:0008134	transcription factor binding	1.12e-01	1.00e+00	3.090	1	18	242
GO:0043025	neuronal cell body	1.13e-01	1.00e+00	3.072	1	9	245
GO:0000166	nucleotide binding	1.19e-01	1.00e+00	2.992	1	13	259
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.21e-01	1.00e+00	2.964	1	23	264
GO:0030198	extracellular matrix organization	1.30e-01	1.00e+00	2.864	1	6	283
GO:0007186	G-protein coupled receptor signaling pathway	1.32e-01	1.00e+00	2.834	1	1	289
GO:0003723	RNA binding	1.55e-01	1.00e+00	2.591	1	18	342
GO:0043565	sequence-specific DNA binding	1.56e-01	1.00e+00	2.574	1	11	346
GO:0005925	focal adhesion	1.65e-01	1.00e+00	2.493	1	9	366
GO:0005730	nucleolus	1.85e-01	1.00e+00	1.328	2	66	1641
GO:0045893	positive regulation of transcription, DNA-templated	2.10e-01	1.00e+00	2.108	1	24	478
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	2.46e-01	1.00e+00	1.854	1	37	570
GO:0005737	cytoplasm	2.67e-01	1.00e+00	0.714	3	124	3767
GO:0005886	plasma membrane	3.65e-01	1.00e+00	0.674	2	49	2582
GO:0005739	mitochondrion	3.95e-01	1.00e+00	1.046	1	23	998
GO:0016021	integral component of membrane	6.45e-01	1.00e+00	0.056	1	17	1982
GO:0070062	extracellular vesicular exosome	7.20e-01	1.00e+00	-0.220	1	57	2400
GO:0005829	cytosol	7.36e-01	1.00e+00	-0.277	1	86	2496

chia-Fav

int-snw-9968

Statistics

Genes (7)

Interactions (7)

Related GO terms (121)