int-snw-9443

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.137	5.99e-19	7.90e-06	1.83e-04

chia-screen-data-Fav-int-snw-9443 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
MED19	219541	30	-2.657	3.449	115	Yes	-
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
MED28	80306	16	-2.404	3.216	80	Yes	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
[ MED7 ]	9443	2	-1.913	3.137	37	-	-
MED14	9282	6	-2.420	3.137	49	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes

Interactions (12)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
MED28	80306	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
YAP1	10413	MED28	80306	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
MED7	9443	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
MED14	9282	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct
MED7	9443	MED28	80306	pp	--	int.I2D: BioGrid
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HCFC1	3054	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
MED14	9282	MED28	80306	pp	--	int.I2D: BioGrid
MED14	9282	MED7	9443	pp	--	int.I2D: BioGrid

Related GO terms (102)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016592	mediator complex	3.63e-09	5.23e-05	7.517	4	10	35
GO:0001104	RNA polymerase II transcription cofactor activity	9.08e-07	1.31e-02	7.187	3	8	33
GO:0019827	stem cell maintenance	2.69e-06	3.88e-02	6.677	3	7	47
GO:0003713	transcription coactivator activity	8.40e-06	1.21e-01	4.757	4	24	237
GO:0005654	nucleoplasm	1.21e-05	1.75e-01	3.152	6	64	1082
GO:0006366	transcription from RNA polymerase II promoter	7.88e-05	1.00e+00	3.935	4	30	419
GO:0006367	transcription initiation from RNA polymerase II promoter	1.62e-04	1.00e+00	4.708	3	22	184
GO:0006357	regulation of transcription from RNA polymerase II promoter	4.69e-04	1.00e+00	4.187	3	23	264
GO:0010467	gene expression	4.79e-04	1.00e+00	3.260	4	45	669
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.24e-04	1.00e+00	10.646	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.24e-04	1.00e+00	10.646	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.24e-04	1.00e+00	10.646	1	1	1
GO:0019046	release from viral latency	1.25e-03	1.00e+00	9.646	1	2	2
GO:0009786	regulation of asymmetric cell division	1.25e-03	1.00e+00	9.646	1	1	2
GO:0060242	contact inhibition	1.25e-03	1.00e+00	9.646	1	1	2
GO:0060913	cardiac cell fate determination	1.87e-03	1.00e+00	9.061	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.87e-03	1.00e+00	9.061	1	1	3
GO:0006355	regulation of transcription, DNA-templated	2.16e-03	1.00e+00	2.685	4	43	997
GO:0051151	negative regulation of smooth muscle cell differentiation	2.49e-03	1.00e+00	8.646	1	1	4
GO:0070461	SAGA-type complex	3.12e-03	1.00e+00	8.324	1	2	5
GO:0001714	endodermal cell fate specification	3.12e-03	1.00e+00	8.324	1	1	5
GO:0044212	transcription regulatory region DNA binding	4.60e-03	1.00e+00	4.254	2	17	168
GO:0016607	nuclear speck	4.82e-03	1.00e+00	4.220	2	12	172
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0043254	regulation of protein complex assembly	4.98e-03	1.00e+00	7.646	1	1	8
GO:0005667	transcription factor complex	4.98e-03	1.00e+00	4.195	2	17	175
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	5.60e-03	1.00e+00	7.476	1	5	9
GO:0048188	Set1C/COMPASS complex	5.60e-03	1.00e+00	7.476	1	4	9
GO:0005634	nucleus	5.94e-03	1.00e+00	1.299	7	159	4559
GO:0035413	positive regulation of catenin import into nucleus	6.22e-03	1.00e+00	7.324	1	2	10
GO:0060391	positive regulation of SMAD protein import into nucleus	6.85e-03	1.00e+00	7.187	1	4	11
GO:0035198	miRNA binding	7.47e-03	1.00e+00	7.061	1	1	12
GO:0071480	cellular response to gamma radiation	8.09e-03	1.00e+00	6.946	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	8.09e-03	1.00e+00	6.946	1	2	13
GO:0008380	RNA splicing	8.32e-03	1.00e+00	3.813	2	22	228
GO:0005685	U1 snRNP	8.70e-03	1.00e+00	6.839	1	1	14
GO:0030518	intracellular steroid hormone receptor signaling pathway	8.70e-03	1.00e+00	6.839	1	6	14
GO:0043981	histone H4-K5 acetylation	9.32e-03	1.00e+00	6.739	1	5	15
GO:0042809	vitamin D receptor binding	9.32e-03	1.00e+00	6.739	1	6	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	9.32e-03	1.00e+00	6.739	1	3	15
GO:0006376	mRNA splice site selection	9.32e-03	1.00e+00	6.739	1	1	15
GO:0001824	blastocyst development	9.32e-03	1.00e+00	6.739	1	2	15
GO:0043982	histone H4-K8 acetylation	9.32e-03	1.00e+00	6.739	1	5	15
GO:0043274	phospholipase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.07e-02	1.00e+00	2.607	3	41	789
GO:0043984	histone H4-K16 acetylation	1.18e-02	1.00e+00	6.398	1	5	19
GO:0000123	histone acetyltransferase complex	1.30e-02	1.00e+00	6.254	1	6	21
GO:0045787	positive regulation of cell cycle	1.36e-02	1.00e+00	6.187	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.36e-02	1.00e+00	6.187	1	4	22
GO:0030864	cortical actin cytoskeleton	1.43e-02	1.00e+00	6.123	1	1	23
GO:0046966	thyroid hormone receptor binding	1.61e-02	1.00e+00	5.946	1	6	26
GO:0035329	hippo signaling	1.61e-02	1.00e+00	5.946	1	5	26
GO:0071339	MLL1 complex	1.67e-02	1.00e+00	5.891	1	6	27
GO:1903507	negative regulation of nucleic acid-templated transcription	1.98e-02	1.00e+00	5.646	1	2	32
GO:0044822	poly(A) RNA binding	2.35e-02	1.00e+00	2.187	3	50	1056
GO:0035019	somatic stem cell maintenance	2.47e-02	1.00e+00	5.324	1	6	40
GO:0030521	androgen receptor signaling pathway	2.53e-02	1.00e+00	5.289	1	5	41
GO:0031124	mRNA 3'-end processing	2.59e-02	1.00e+00	5.254	1	2	42
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	2.65e-02	1.00e+00	5.220	1	7	43
GO:0003712	transcription cofactor activity	2.71e-02	1.00e+00	5.187	1	8	44
GO:0006369	termination of RNA polymerase II transcription	2.77e-02	1.00e+00	5.154	1	2	45
GO:0009611	response to wounding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0005515	protein binding	3.23e-02	1.00e+00	0.897	7	198	6024
GO:0006406	mRNA export from nucleus	3.74e-02	1.00e+00	4.715	1	4	61
GO:0010468	regulation of gene expression	4.17e-02	1.00e+00	4.559	1	2	68
GO:0003729	mRNA binding	4.41e-02	1.00e+00	4.476	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.53e-02	1.00e+00	4.437	1	4	74
GO:0009653	anatomical structure morphogenesis	5.06e-02	1.00e+00	4.271	1	2	83
GO:0050821	protein stabilization	5.36e-02	1.00e+00	4.187	1	3	88
GO:0003700	sequence-specific DNA binding transcription factor activity	6.73e-02	1.00e+00	2.197	2	39	699
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	12	118
GO:0016020	membrane	7.75e-02	1.00e+00	1.516	3	46	1681
GO:0010628	positive regulation of gene expression	8.75e-02	1.00e+00	3.456	1	7	146
GO:0006974	cellular response to DNA damage stimulus	9.04e-02	1.00e+00	3.408	1	7	151
GO:0000398	mRNA splicing, via spliceosome	9.78e-02	1.00e+00	3.289	1	15	164
GO:0031965	nuclear membrane	1.00e-01	1.00e+00	3.254	1	10	168
GO:0007049	cell cycle	1.04e-01	1.00e+00	3.203	1	6	174
GO:0031625	ubiquitin protein ligase binding	1.06e-01	1.00e+00	3.170	1	5	178
GO:0003714	transcription corepressor activity	1.06e-01	1.00e+00	3.170	1	11	178
GO:0004872	receptor activity	1.12e-01	1.00e+00	3.084	1	8	189
GO:0005739	mitochondrion	1.25e-01	1.00e+00	1.683	2	23	998
GO:0008134	transcription factor binding	1.41e-01	1.00e+00	2.727	1	18	242
GO:0043025	neuronal cell body	1.43e-01	1.00e+00	2.710	1	9	245
GO:0000166	nucleotide binding	1.51e-01	1.00e+00	2.629	1	13	259
GO:0003779	actin binding	1.54e-01	1.00e+00	2.591	1	10	266
GO:0003677	DNA binding	1.73e-01	1.00e+00	1.396	2	49	1218
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.767	4	124	3767
GO:0003682	chromatin binding	1.87e-01	1.00e+00	2.293	1	19	327
GO:0008283	cell proliferation	1.87e-01	1.00e+00	2.289	1	14	328
GO:0003723	RNA binding	1.94e-01	1.00e+00	2.228	1	18	342
GO:0043565	sequence-specific DNA binding	1.96e-01	1.00e+00	2.212	1	11	346
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	9	366
GO:0045893	positive regulation of transcription, DNA-templated	2.62e-01	1.00e+00	1.745	1	24	478
GO:0042802	identical protein binding	2.65e-01	1.00e+00	1.727	1	19	484
GO:0005730	nucleolus	2.73e-01	1.00e+00	0.966	2	66	1641
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	3.04e-01	1.00e+00	1.491	1	37	570
GO:0005829	cytosol	4.79e-01	1.00e+00	0.361	2	86	2496
GO:0006351	transcription, DNA-templated	6.14e-01	1.00e+00	0.148	1	57	1446
GO:0005886	plasma membrane	8.31e-01	1.00e+00	-0.688	1	49	2582

chia-Fav

int-snw-9443

Statistics

Genes (9)

Interactions (12)

Related GO terms (102)